CN117500781A - N-((r)-2,3-二羟基丙氧基)-3,4-二氟-2-(2-氟-4-碘-苯氨基)-苯甲酰胺的基本上纯的形式iv的组合物及其用途 - Google Patents
N-((r)-2,3-二羟基丙氧基)-3,4-二氟-2-(2-氟-4-碘-苯氨基)-苯甲酰胺的基本上纯的形式iv的组合物及其用途 Download PDFInfo
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- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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Landscapes
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2021/018378 WO2022177556A1 (en) | 2021-02-17 | 2021-02-17 | Compositions of essentially pure form iv of n-((r)-2,3- dihydroxypropoxy)-3,4-difluoro-2- (2-fluoro-4-iodophenylamino)- benzamide and uses thereof |
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| EP (1) | EP4294789A1 (ja) |
| JP (1) | JP2024507822A (ja) |
| KR (1) | KR20230148177A (ja) |
| CN (1) | CN117500781A (ja) |
| AR (1) | AR124907A1 (ja) |
| AU (1) | AU2021428932A1 (ja) |
| CA (1) | CA3211395A1 (ja) |
| IL (1) | IL304974A (ja) |
| TW (1) | TW202245746A (ja) |
| WO (1) | WO2022177556A1 (ja) |
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| WO2023223205A1 (en) | 2022-05-17 | 2023-11-23 | Teva Pharmaceuticals International Gmbh | Solid state forms of mirdametinib and process for preparation thereof |
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| AU2001273498B2 (en) | 2000-07-19 | 2006-08-24 | Warner-Lambert Company | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids |
| AU2004283148A1 (en) | 2003-10-21 | 2005-05-06 | Warner-Lambert Company Llc | Polymorphic form of N-[(R)-2,3-Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide |
| WO2006134469A1 (en) | 2005-06-14 | 2006-12-21 | Warner-Lambert Company Llc | Methods of preparing mek inhibitor |
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- 2021-02-17 JP JP2023549999A patent/JP2024507822A/ja active Pending
- 2021-02-17 KR KR1020237030268A patent/KR20230148177A/ko unknown
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- 2021-02-17 AU AU2021428932A patent/AU2021428932A1/en active Pending
- 2021-02-17 CN CN202180095226.2A patent/CN117500781A/zh active Pending
- 2021-02-17 EP EP21710827.3A patent/EP4294789A1/en active Pending
- 2021-02-17 IL IL304974A patent/IL304974A/en unknown
- 2021-02-17 CA CA3211395A patent/CA3211395A1/en active Pending
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| Publication number | Publication date |
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| AU2021428932A1 (en) | 2023-09-21 |
| IL304974A (en) | 2023-10-01 |
| JP2024507822A (ja) | 2024-02-21 |
| TW202245746A (zh) | 2022-12-01 |
| AR124907A1 (es) | 2023-05-17 |
| WO2022177556A1 (en) | 2022-08-25 |
| KR20230148177A (ko) | 2023-10-24 |
| CA3211395A1 (en) | 2022-08-25 |
| EP4294789A1 (en) | 2023-12-27 |
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