CN117482374A - 使用电穿孔对脂肪组织进行微创体内转染的方法和装置 - Google Patents

使用电穿孔对脂肪组织进行微创体内转染的方法和装置 Download PDF

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Publication number
CN117482374A
CN117482374A CN202311412748.8A CN202311412748A CN117482374A CN 117482374 A CN117482374 A CN 117482374A CN 202311412748 A CN202311412748 A CN 202311412748A CN 117482374 A CN117482374 A CN 117482374A
Authority
CN
China
Prior art keywords
electrode
tissue
fat
contact surface
electroporation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202311412748.8A
Other languages
English (en)
Chinese (zh)
Inventor
保尔·费希尔
凯特·布罗德里克
杰伊·麦克科伊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inovio Pharmaceuticals Inc
Original Assignee
Inovio Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inovio Pharmaceuticals Inc filed Critical Inovio Pharmaceuticals Inc
Publication of CN117482374A publication Critical patent/CN117482374A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/042—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Surgical Instruments (AREA)
  • Electrotherapy Devices (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Prostheses (AREA)
CN202311412748.8A 2016-09-23 2017-09-22 使用电穿孔对脂肪组织进行微创体内转染的方法和装置 Pending CN117482374A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662398932P 2016-09-23 2016-09-23
US62/398,932 2016-09-23
US201762480180P 2017-03-31 2017-03-31
US62/480,180 2017-03-31
CN201780071035.6A CN110022931B (zh) 2016-09-23 2017-09-22 用于使用电穿孔对脂肪组织进行微创体内转染的方法和装置
PCT/US2017/052970 WO2018057900A1 (en) 2016-09-23 2017-09-22 Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201780071035.6A Division CN110022931B (zh) 2016-09-23 2017-09-22 用于使用电穿孔对脂肪组织进行微创体内转染的方法和装置

Publications (1)

Publication Number Publication Date
CN117482374A true CN117482374A (zh) 2024-02-02

Family

ID=61690748

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202311412748.8A Pending CN117482374A (zh) 2016-09-23 2017-09-22 使用电穿孔对脂肪组织进行微创体内转染的方法和装置
CN201780071035.6A Active CN110022931B (zh) 2016-09-23 2017-09-22 用于使用电穿孔对脂肪组织进行微创体内转染的方法和装置

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201780071035.6A Active CN110022931B (zh) 2016-09-23 2017-09-22 用于使用电穿孔对脂肪组织进行微创体内转染的方法和装置

Country Status (10)

Country Link
US (2) US11684777B2 (https=)
EP (2) EP3515549B1 (https=)
JP (3) JP7181186B2 (https=)
KR (4) KR20230155616A (https=)
CN (2) CN117482374A (https=)
AU (4) AU2017331263B2 (https=)
CA (2) CA3037527A1 (https=)
ES (1) ES2970888T3 (https=)
MX (2) MX2019003335A (https=)
WO (1) WO2018057900A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3615660A4 (en) * 2017-04-26 2021-01-13 Ravata Solutions, Inc. MICROELECTRODE PROCESSING FOR ELECTROPORATION
AU2021388154A1 (en) * 2020-11-25 2023-06-22 Flagship Pioneering Innovations Vi, Llc Adipogenic cell compositions and methods

Family Cites Families (28)

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US6009345A (en) 1992-08-17 1999-12-28 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
US6216034B1 (en) * 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6778853B1 (en) * 1997-12-17 2004-08-17 University Of South Florida Electroporation device
JP2000139943A (ja) 1998-09-02 2000-05-23 Olympus Optical Co Ltd 高周波処置具
JP3384750B2 (ja) 1998-09-02 2003-03-10 オリンパス光学工業株式会社 高周波処置具
US6937890B2 (en) 1998-12-17 2005-08-30 University Of South Florida Nonpenetrating electroporation device
DE10032000A1 (de) 1999-07-01 2001-01-25 Medtronic Inc Medizinisches Gerät und Verfahren zur elektrophoretischen in situ Abgabe eines therapheutischen Wirkstoffs
US8251986B2 (en) * 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6892099B2 (en) * 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
JP3895633B2 (ja) 2002-04-19 2007-03-22 株式会社ザナヴィ・インフォマティクス 表示装置、情報処理装置、情報処理システム
JP2006293725A (ja) 2005-04-12 2006-10-26 Matsushita Electric Ind Co Ltd Ｌｓｉシステム向けデバッグ装置
US20060293725A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating fatty tissue sites using electroporation
EP1928540A4 (en) 2005-09-07 2010-03-10 The Foundry Inc DEVICE AND METHOD FOR INTERRUPTING SUBCUTANEOUS STRUCTURES
US7967763B2 (en) 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US8133191B2 (en) 2006-02-16 2012-03-13 Syneron Medical Ltd. Method and apparatus for treatment of adipose tissue
JP2010524591A (ja) 2007-04-19 2010-07-22 ザ ファウンドリー， インコーポレイテッド 汗の産生を低減するための方法および装置
JP5098024B2 (ja) 2007-11-07 2012-12-12 有限会社リバー精工 内視鏡用高周波処置具
KR101642523B1 (ko) 2008-01-17 2016-07-25 제네트로닉스, 인코포레이티드 가변성 전류 밀도 단일 바늘 전기 천공 시스템
JP4955634B2 (ja) 2008-09-24 2012-06-20 テルモ株式会社 薬剤投与具
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Also Published As

Publication number Publication date
KR102423446B1 (ko) 2022-07-21
EP4238607A3 (en) 2023-11-08
ES2970888T3 (es) 2024-05-31
BR112019005740A2 (pt) 2019-06-18
AU2023202108A1 (en) 2023-05-04
US11684777B2 (en) 2023-06-27
CN110022931B (zh) 2023-11-14
JP7181186B2 (ja) 2022-11-30
WO2018057900A1 (en) 2018-03-29
US20200016400A1 (en) 2020-01-16
KR102313881B1 (ko) 2021-10-18
JP7448603B2 (ja) 2024-03-12
US20230248965A1 (en) 2023-08-10
CN110022931A (zh) 2019-07-16
EP3515549A1 (en) 2019-07-31
CA3204936A1 (en) 2018-03-29
MX2024007241A (es) 2024-06-26
KR102599298B1 (ko) 2023-11-07
AU2017331263B2 (en) 2020-07-09
MX2019003335A (es) 2019-12-11
EP3515549A4 (en) 2020-06-10
JP2020500039A (ja) 2020-01-09
JP2022188120A (ja) 2022-12-20
KR20190055155A (ko) 2019-05-22
JP2024054418A (ja) 2024-04-16
KR20210127797A (ko) 2021-10-22
AU2020250317A1 (en) 2020-11-12
AU2017331263A1 (en) 2019-04-18
KR20220104077A (ko) 2022-07-25
AU2020250317B2 (en) 2023-01-05
KR20230155616A (ko) 2023-11-10
AU2025213675A1 (en) 2025-08-28
CA3037527A1 (en) 2018-03-29
EP4238607A2 (en) 2023-09-06
EP3515549B1 (en) 2023-11-22

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