BR112019005740A2 - método e dispositivo para transfecção in vivo mini-mamente invasiva de tecido adiposo com o uso de eletroporação - Google Patents

método e dispositivo para transfecção in vivo mini-mamente invasiva de tecido adiposo com o uso de eletroporação

Info

Publication number
BR112019005740A2
BR112019005740A2 BR112019005740A BR112019005740A BR112019005740A2 BR 112019005740 A2 BR112019005740 A2 BR 112019005740A2 BR 112019005740 A BR112019005740 A BR 112019005740A BR 112019005740 A BR112019005740 A BR 112019005740A BR 112019005740 A2 BR112019005740 A2 BR 112019005740A2
Authority
BR
Brazil
Prior art keywords
adipose tissue
electroporation
contact surface
invasively
mini
Prior art date
Application number
BR112019005740A
Other languages
English (en)
Inventor
Mccoy Jay
Broderick Kate
Fisher Paul
Original Assignee
Inovio Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inovio Pharmaceuticals Inc filed Critical Inovio Pharmaceuticals Inc
Publication of BR112019005740A2 publication Critical patent/BR112019005740A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/042—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Surgical Instruments (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Electrotherapy Devices (AREA)
  • Prostheses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

a presente invenção refere-se a um método e dispositivo para eletroporação de adipócitos na camada adiposa de tecido, em que o dispositivo inclui uma armação, um primeiro eletrodo acoplado à armação que tem uma primeira superfície de contato, um segundo eletrodo acoplado à armação que tem uma segunda superfície de contato, e em que a primeira superfície de contato e a segunda superfície de contato definem uma zona de tratamento entre as mesmas. o método inclui o posicionamento de uma dobra de tecido entre o primeiro e o segundo eletrodos de modo que a zona de tratamento formada entre os dois eletrodos inclua uma camada adiposa de tecido e nenhum músculo esquelético.
BR112019005740A 2016-09-23 2017-09-22 método e dispositivo para transfecção in vivo mini-mamente invasiva de tecido adiposo com o uso de eletroporação BR112019005740A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662398932P 2016-09-23 2016-09-23
US201762480180P 2017-03-31 2017-03-31
PCT/US2017/052970 WO2018057900A1 (en) 2016-09-23 2017-09-22 Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation

Publications (1)

Publication Number Publication Date
BR112019005740A2 true BR112019005740A2 (pt) 2019-06-18

Family

ID=61690748

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019005740A BR112019005740A2 (pt) 2016-09-23 2017-09-22 método e dispositivo para transfecção in vivo mini-mamente invasiva de tecido adiposo com o uso de eletroporação

Country Status (10)

Country Link
US (2) US11684777B2 (pt)
EP (2) EP3515549B1 (pt)
JP (3) JP7181186B2 (pt)
KR (4) KR102423446B1 (pt)
CN (2) CN110022931B (pt)
AU (3) AU2017331263B2 (pt)
BR (1) BR112019005740A2 (pt)
CA (2) CA3037527A1 (pt)
MX (1) MX2019003335A (pt)
WO (1) WO2018057900A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018200873A1 (en) * 2017-04-26 2018-11-01 Ravata Solutions, Inc. Microelectrode techniques for electroporation
KR20230113346A (ko) * 2020-11-25 2023-07-28 플래그쉽 파이어니어링, 인크. 지방생성 세포 조성물 및 방법

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US6009345A (en) 1992-08-17 1999-12-28 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
US6216034B1 (en) * 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6778853B1 (en) * 1997-12-17 2004-08-17 University Of South Florida Electroporation device
JP3384750B2 (ja) 1998-09-02 2003-03-10 オリンパス光学工業株式会社 高周波処置具
JP2000139943A (ja) 1998-09-02 2000-05-23 Olympus Optical Co Ltd 高周波処置具
US6937890B2 (en) 1998-12-17 2005-08-30 University Of South Florida Nonpenetrating electroporation device
DE10032000A1 (de) * 1999-07-01 2001-01-25 Medtronic Inc Medizinisches Gerät und Verfahren zur elektrophoretischen in situ Abgabe eines therapheutischen Wirkstoffs
US8251986B2 (en) * 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6697670B2 (en) * 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6892099B2 (en) * 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
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JP3895633B2 (ja) * 2002-04-19 2007-03-22 株式会社ザナヴィ・インフォマティクス 表示装置、情報処理装置、情報処理システム
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Also Published As

Publication number Publication date
CA3037527A1 (en) 2018-03-29
AU2023202108A1 (en) 2023-05-04
CN110022931B (zh) 2023-11-14
JP2020500039A (ja) 2020-01-09
KR20210127797A (ko) 2021-10-22
EP4238607A2 (en) 2023-09-06
KR20230155616A (ko) 2023-11-10
US20230248965A1 (en) 2023-08-10
JP7448603B2 (ja) 2024-03-12
KR20220104077A (ko) 2022-07-25
JP7181186B2 (ja) 2022-11-30
MX2019003335A (es) 2019-12-11
JP2022188120A (ja) 2022-12-20
KR20190055155A (ko) 2019-05-22
WO2018057900A1 (en) 2018-03-29
AU2017331263B2 (en) 2020-07-09
JP2024054418A (ja) 2024-04-16
CN110022931A (zh) 2019-07-16
EP3515549B1 (en) 2023-11-22
US20200016400A1 (en) 2020-01-16
US11684777B2 (en) 2023-06-27
KR102423446B1 (ko) 2022-07-21
KR102599298B1 (ko) 2023-11-07
EP4238607A3 (en) 2023-11-08
AU2020250317A1 (en) 2020-11-12
EP3515549A4 (en) 2020-06-10
CN117482374A (zh) 2024-02-02
KR102313881B1 (ko) 2021-10-18
CA3204936A1 (en) 2018-03-29
AU2020250317B2 (en) 2023-01-05
EP3515549A1 (en) 2019-07-31
AU2017331263A1 (en) 2019-04-18

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: A61N 1/18 , A61N 1/32

Ipc: A61N 1/04 (2006.01), A61N 1/32 (2006.01)

B154 Notification of filing of divisional application [chapter 15.50 patent gazette]

Free format text: O PEDIDO FOI DIVIDIDO NO BR122023017876-9 PROTOCOLO 870230078280 EM 04/09/2023 12:23.