CA3037527A1 - Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation - Google Patents

Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation Download PDF

Info

Publication number
CA3037527A1
CA3037527A1 CA3037527A CA3037527A CA3037527A1 CA 3037527 A1 CA3037527 A1 CA 3037527A1 CA 3037527 A CA3037527 A CA 3037527A CA 3037527 A CA3037527 A CA 3037527A CA 3037527 A1 CA3037527 A1 CA 3037527A1
Authority
CA
Canada
Prior art keywords
tissue
electrode
adipose
contact surface
fold
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3037527A
Other languages
English (en)
French (fr)
Inventor
Paul Fisher
Kate Broderick
Jay Mccoy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inovio Pharmaceuticals Inc
Original Assignee
Inovio Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inovio Pharmaceuticals Inc filed Critical Inovio Pharmaceuticals Inc
Priority to CA3204936A priority Critical patent/CA3204936A1/en
Publication of CA3037527A1 publication Critical patent/CA3037527A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/042—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Surgical Instruments (AREA)
  • Electrotherapy Devices (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Prostheses (AREA)
CA3037527A 2016-09-23 2017-09-22 Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation Pending CA3037527A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3204936A CA3204936A1 (en) 2016-09-23 2017-09-22 Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662398932P 2016-09-23 2016-09-23
US62/398,932 2016-09-23
US201762480180P 2017-03-31 2017-03-31
US62/480,180 2017-03-31
PCT/US2017/052970 WO2018057900A1 (en) 2016-09-23 2017-09-22 Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3204936A Division CA3204936A1 (en) 2016-09-23 2017-09-22 Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation

Publications (1)

Publication Number Publication Date
CA3037527A1 true CA3037527A1 (en) 2018-03-29

Family

ID=61690748

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3037527A Pending CA3037527A1 (en) 2016-09-23 2017-09-22 Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation
CA3204936A Pending CA3204936A1 (en) 2016-09-23 2017-09-22 Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3204936A Pending CA3204936A1 (en) 2016-09-23 2017-09-22 Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation

Country Status (10)

Country Link
US (2) US11684777B2 (https=)
EP (2) EP3515549B1 (https=)
JP (3) JP7181186B2 (https=)
KR (4) KR20230155616A (https=)
CN (2) CN117482374A (https=)
AU (4) AU2017331263B2 (https=)
CA (2) CA3037527A1 (https=)
ES (1) ES2970888T3 (https=)
MX (2) MX2019003335A (https=)
WO (1) WO2018057900A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3615660A4 (en) * 2017-04-26 2021-01-13 Ravata Solutions, Inc. MICROELECTRODE PROCESSING FOR ELECTROPORATION
AU2021388154A1 (en) * 2020-11-25 2023-06-22 Flagship Pioneering Innovations Vi, Llc Adipogenic cell compositions and methods

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6009345A (en) 1992-08-17 1999-12-28 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
US6216034B1 (en) * 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6778853B1 (en) * 1997-12-17 2004-08-17 University Of South Florida Electroporation device
JP2000139943A (ja) 1998-09-02 2000-05-23 Olympus Optical Co Ltd 高周波処置具
JP3384750B2 (ja) 1998-09-02 2003-03-10 オリンパス光学工業株式会社 高周波処置具
US6937890B2 (en) 1998-12-17 2005-08-30 University Of South Florida Nonpenetrating electroporation device
DE10032000A1 (de) 1999-07-01 2001-01-25 Medtronic Inc Medizinisches Gerät und Verfahren zur elektrophoretischen in situ Abgabe eines therapheutischen Wirkstoffs
US8251986B2 (en) * 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6892099B2 (en) * 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
JP3895633B2 (ja) 2002-04-19 2007-03-22 株式会社ザナヴィ・インフォマティクス 表示装置、情報処理装置、情報処理システム
JP2006293725A (ja) 2005-04-12 2006-10-26 Matsushita Electric Ind Co Ltd Ｌｓｉシステム向けデバッグ装置
US20060293725A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating fatty tissue sites using electroporation
EP1928540A4 (en) 2005-09-07 2010-03-10 The Foundry Inc DEVICE AND METHOD FOR INTERRUPTING SUBCUTANEOUS STRUCTURES
US7967763B2 (en) 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US8133191B2 (en) 2006-02-16 2012-03-13 Syneron Medical Ltd. Method and apparatus for treatment of adipose tissue
JP2010524591A (ja) 2007-04-19 2010-07-22 ザ ファウンドリー， インコーポレイテッド 汗の産生を低減するための方法および装置
JP5098024B2 (ja) 2007-11-07 2012-12-12 有限会社リバー精工 内視鏡用高周波処置具
KR101642523B1 (ko) 2008-01-17 2016-07-25 제네트로닉스, 인코포레이티드 가변성 전류 밀도 단일 바늘 전기 천공 시스템
JP4955634B2 (ja) 2008-09-24 2012-06-20 テルモ株式会社 薬剤投与具
US20110112520A1 (en) 2009-11-11 2011-05-12 Invasix Corporation Method and device for fat treatment
US9005198B2 (en) * 2010-01-29 2015-04-14 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
KR101182330B1 (ko) 2010-04-07 2012-09-20 두산중공업 주식회사 터빈 속도 제어 시스템
US20130030430A1 (en) * 2011-07-29 2013-01-31 Stewart Mark T Intracardiac tools and methods for delivery of electroporation therapies
US10071244B2 (en) * 2012-12-21 2018-09-11 University College Cork—National University of Ireland, Cork Thoracoscopic electroporation device with a suction head and with needle electrodes
US9545523B2 (en) * 2013-03-14 2017-01-17 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
WO2015192018A1 (en) 2014-06-12 2015-12-17 Iowa Approach Inc. Method and apparatus for rapid and selective tissue ablation with cooling

Also Published As

Publication number Publication date
KR102423446B1 (ko) 2022-07-21
EP4238607A3 (en) 2023-11-08
ES2970888T3 (es) 2024-05-31
BR112019005740A2 (pt) 2019-06-18
AU2023202108A1 (en) 2023-05-04
US11684777B2 (en) 2023-06-27
CN110022931B (zh) 2023-11-14
JP7181186B2 (ja) 2022-11-30
CN117482374A (zh) 2024-02-02
WO2018057900A1 (en) 2018-03-29
US20200016400A1 (en) 2020-01-16
KR102313881B1 (ko) 2021-10-18
JP7448603B2 (ja) 2024-03-12
US20230248965A1 (en) 2023-08-10
CN110022931A (zh) 2019-07-16
EP3515549A1 (en) 2019-07-31
CA3204936A1 (en) 2018-03-29
MX2024007241A (es) 2024-06-26
KR102599298B1 (ko) 2023-11-07
AU2017331263B2 (en) 2020-07-09
MX2019003335A (es) 2019-12-11
EP3515549A4 (en) 2020-06-10
JP2020500039A (ja) 2020-01-09
JP2022188120A (ja) 2022-12-20
KR20190055155A (ko) 2019-05-22
JP2024054418A (ja) 2024-04-16
KR20210127797A (ko) 2021-10-22
AU2020250317A1 (en) 2020-11-12
AU2017331263A1 (en) 2019-04-18
KR20220104077A (ko) 2022-07-25
AU2020250317B2 (en) 2023-01-05
KR20230155616A (ko) 2023-11-10
AU2025213675A1 (en) 2025-08-28
EP4238607A2 (en) 2023-09-06
EP3515549B1 (en) 2023-11-22

Similar Documents

Publication Publication Date Title
AU2025213675A1 (en) Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation
CN113613711B (zh) 使用微电极进行组织电转移的装置
US20210353939A1 (en) Multiple Tissue Layer Electroporation Applicator and Device
Bulysheva et al. Monopolar gene electrotransfer enhances plasmid DNA delivery to skin
HK40105183A (zh) 使用电穿孔对脂肪组织进行微创体内转染的方法和装置
EA040433B1 (ru) Способ и устройство для электропорации адипоцитов в адипозной ткани
HK40009410A (en) Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation
HK40009410B (zh) 用於使用电穿孔对脂肪组织进行微创体内转染的方法和装置
BR112019005740B1 (pt) Dispositivo de eletroporação
JP2023523857A (ja) 細胞の透過化およびトランスフェクションを強化するために吸引を使用するシステムおよび方法
Kos et al. Utilization of multi-array electrodes for delivery of drugs and genes in the mouse skin
BR112012021805B1 (pt) Dispositivo de eletroporação capaz de fornecer a um indivíduo um potencial elétrico tolerável às camadas do tecido epidérmico entre o estrato córneo e as camadas basais

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20190319

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 7TH ANNIV.) - STANDARD

Year of fee payment: 7

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240917

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20240917

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20240917

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20241129

B12 Application deemed to be withdrawn, abandoned or lapsed

Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B12-B303 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO AN EXAMINER'S REQUISITION

Effective date: 20250331

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20251106