CN117482292A - 一种胶原蛋白多孔微球及其制备方法和应用 - Google Patents
一种胶原蛋白多孔微球及其制备方法和应用 Download PDFInfo
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- CN117482292A CN117482292A CN202311524550.9A CN202311524550A CN117482292A CN 117482292 A CN117482292 A CN 117482292A CN 202311524550 A CN202311524550 A CN 202311524550A CN 117482292 A CN117482292 A CN 117482292A
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- Prior art keywords
- collagen
- mass
- crosslinking
- degreasing
- solution
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 122
- 108010035532 Collagen Proteins 0.000 title claims abstract description 122
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- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000007864 aqueous solution Substances 0.000 claims abstract description 36
- 239000003929 acidic solution Substances 0.000 claims abstract description 25
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 48
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 231100000987 absorbed dose Toxicity 0.000 description 1
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Abstract
Description
编号 | 胶原蛋白中I型胶原蛋白的浓度 |
实施例5 | 97.2wt% |
实施例6 | 99.2wt% |
编号 | 抗压强度(MPa) |
实施例2 | 0.148 |
实施例5 | 0.152 |
实施例6 | 0.156 |
实施例7 | 0.169 |
对比例1 | 0.052 |
对比例4 | 0.118 |
Claims (10)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CN202311196035 | 2023-09-15 | ||
CN2023111960352 | 2023-09-15 |
Publications (1)
Publication Number | Publication Date |
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CN117482292A true CN117482292A (zh) | 2024-02-02 |
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CN202311524550.9A Pending CN117482292A (zh) | 2023-09-15 | 2023-11-15 | 一种胶原蛋白多孔微球及其制备方法和应用 |
Country Status (1)
Country | Link |
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CN (1) | CN117482292A (zh) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002040242A1 (en) * | 2000-11-17 | 2002-05-23 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen |
US20060204539A1 (en) * | 2005-03-11 | 2006-09-14 | Anthony Atala | Electrospun cell matrices |
US20070160653A1 (en) * | 2006-01-11 | 2007-07-12 | Fischer Thomas H | Hemostatic textile |
EP2021035A2 (en) * | 2006-05-19 | 2009-02-11 | The University of Hong Kong | Cell-matrix microspheres, methods for preparation and applications |
CN103276472A (zh) * | 2013-06-03 | 2013-09-04 | 郑州大学 | 胶原蛋白/聚乙烯醇复合微球及其制备方法和用途 |
CN105597144A (zh) * | 2015-12-31 | 2016-05-25 | 北京湃生生物科技有限公司 | 一种可吸收胶原止血粉及其制备方法 |
US20170247430A1 (en) * | 2014-09-26 | 2017-08-31 | University Of South Carolina | Novel biofabrication techniques for the implementation of intrinsic tissue geometries to an in vitro collagen hydrogel |
-
2023
- 2023-11-15 CN CN202311524550.9A patent/CN117482292A/zh active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002040242A1 (en) * | 2000-11-17 | 2002-05-23 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen |
US20060204539A1 (en) * | 2005-03-11 | 2006-09-14 | Anthony Atala | Electrospun cell matrices |
US20070160653A1 (en) * | 2006-01-11 | 2007-07-12 | Fischer Thomas H | Hemostatic textile |
EP2021035A2 (en) * | 2006-05-19 | 2009-02-11 | The University of Hong Kong | Cell-matrix microspheres, methods for preparation and applications |
CN103276472A (zh) * | 2013-06-03 | 2013-09-04 | 郑州大学 | 胶原蛋白/聚乙烯醇复合微球及其制备方法和用途 |
US20170247430A1 (en) * | 2014-09-26 | 2017-08-31 | University Of South Carolina | Novel biofabrication techniques for the implementation of intrinsic tissue geometries to an in vitro collagen hydrogel |
CN105597144A (zh) * | 2015-12-31 | 2016-05-25 | 北京湃生生物科技有限公司 | 一种可吸收胶原止血粉及其制备方法 |
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