CN117462617A - A series of Chinese medicinal preparations for treating femur head necrosis - Google Patents

Abstract

The invention discloses a series of Chinese medicaments mainly used for treating femoral head necrosis by taking an oral preparation, belonging to the technical field of Chinese medicaments. The traditional Chinese medicine disclosed by the invention is a compound prescription, comprises four dosage forms, namely a bone supplementing tablet, a medicated bath agent, a fumigation agent and a plaster agent, wherein each dosage form respectively treats different symptoms according to different dialectical symptoms, such as qi stagnation and blood stasis type, qi deficiency and blood stasis type, kidney yang deficiency type, liver and kidney deficiency type, spleen yang deficiency type, damp-heat type, kidney deficiency and toxin stasis type and the like, and can be used for treating various femoral head necrosis diseases effectively by respectively assisting different medicines according to the severity of symptoms.

Description

A series of Chinese medicinal preparations for treating femur head necrosis

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a series of traditional Chinese medicines taking an oral preparation as a main treatment for femoral head necrosis.

Background

In modern society, people's diet range is becoming wider. Moreover, with the development of social economy, the physical labor of people is gradually reduced, and the intake of various kinds of pungent foods such as raw foods, cold foods, spicy foods and the like, and the lack of exercise, the symptoms such as body ache and swelling and the like can be generated for a long time. This characteristic is aggravated by prolonged cold in the local body, moisture is formed in the body, liquid is formed by prolonged moisture accumulation in the body, symptoms such as effusion prevent bone blood supply, and further bone does not absorb nutrition and gradually changes color, and finally necrosis phenomena such as typical femoral head necrosis occur. Currently, there is no effective treatment for femoral head necrosis (especially in severe cases), most of which is surgically replaced by stainless steel. Stainless steel can absorb temperature and energy in the body, bring local low temperature conditions and cause various sequelae. Meanwhile, the treatment mode of the operation belongs to wound treatment, and not only causes huge economic burden to patients, but also brings various infection risks.

The Chinese traditional medicine of China further explores femoral head necrosis, basically takes internal treatment as the main part and external treatment as the auxiliary part, and the femoral head necrosis takes dialectical treatment as the principle due to different etiology and symptoms, clinically takes internal treatment as the main part and cooperates with external treatment, and the internal and external treatment can accelerate metabolism of organisms and regeneration of capillary vessels, thereby being beneficial to necrotic bone absorption and new bone growth.

The traditional Chinese medicine composition disclosed in the prior art generally treats femoral head necrosis with basic curative effect, and does not have dialectical treatment, so that the curative effect of some symptoms is not good.

Disclosure of Invention

In order to solve the problems, the invention provides a series of traditional Chinese medicines taking an oral preparation as a main treatment for femoral head necrosis, combines an internal treatment method of the traditional Chinese medicines with external use, provides medicine combinations with different symptoms/pharmacology, dialectical medicines, promotes capillary vessel regeneration, accelerates metabolism and absorption of necrotic bones, promotes the growth of new bone, and achieves the effect of repairing the femoral head by self.

In a first aspect, the invention provides a series of Chinese medicaments mainly used for treating femoral head necrosis by taking an oral preparation,

comprises a bone plate composition;

or comprises a bone slice composition, a medicated bath composition, a steaming and steaming composition or a plaster composition which are matched with the bone slice composition for use;

the bone slice composition comprises a first composition with the effects of tonifying kidney and strengthening bones, a second composition with the effects of activating blood and dissolving stasis, a third composition with the effects of tonifying qi and nourishing blood, and a fourth composition with the effects of dispelling wind and dispelling cold.

Further, the first composition comprises the following raw materials:

15g of drynaria rhizome, 6g of deer-horn glue, 3g of dragon's blood, 12g of grassleaf sweelflag rhizome, 15g of twotooth achyranthes root, 15g of cortex acanthopanacis, 12g of himalayan teasel root, 12g of Chinese angelica, 12g of eucommia bark, 12g of safflower, 15g of red sage root, 15g of suberect spatholobus stem, 9g of frankincense, 9g of myrrh and 6g of liquorice.

Further, the second composition comprises the following raw materials:

12g of grassleaf sweelflag rhizome, 12g of ground beetle, 3g of grass cream, 15g of suberect spatholobus stem and 3g of calcined native copper.

Further, the third composition comprises the following raw materials:

18g of astragalus, 12g of fleece-flower root, 12g of pangolin scales, 9g of angelica dahurica, 15g of dragon's blood, 18g of drynaria rhizome, 3g of sappan wood, 6g of suberect spatholobus stem, 3g of gentiana macrophylla, 3g of achyranthes root and 3g of costustoot.

Further, the fourth composition comprises the following raw materials in parts by weight:

3g of long-noded pit viper, 9g of radix angelicae pubescentis, 9g of peach kernel, 6g of divaricate saposhnikovia root, 6g of ginseng, 9g of safflower, 9g of twotooth achyranthes root, 3g of chicken's gizzard-skin, 9g of amur corktree bark, 9g of rhizoma atractylodis, 18g of coix seed, 16g of radix clematidis and 6g of cassia twig.

Further, the medicated bath composition comprises the following raw materials:

18g of drynaria rhizome, 12g of garden balsam stem, 12g of lycopodium clavatum, 6g of semen Impatientis, 12g of large-leaved gentian, 12g of divaricate saposhnikovia root, 6g of lithospermum, 12g of herba lycopi, 15g of suberect spatholobus stem, 12g of Chinese angelica, 12g of safflower and 6g of liquorice;

or 6g of semen Impatientis, 12g of rhizoma sparganii, 12g of rhizoma curcumae, 12g of herba speranskiae tuberculatae, 12g of herba lycopodii, 12g of caulis lonicerae, 9g of herba taxilli, 9g of radix paeoniae alba, 9g of ligusticum chuanxiong, 9g of angelica sinensis, 9g of safflower, 12g of radix clematidis and 6g of liquorice.

Further, the steaming and boiling composition comprises the following raw materials:

18g of drynaria rhizome, 12g of zedoary, 12g of grassleaf sweelflag rhizome, 6g of cocklebur fruit, 12g of cortex acanthopanacis, 12g of apocynum venetum, 12g of common burreed rhizome, 12g of sappan wood, 12g of Chinese angelica, 12g of red paeony root, 9g of safflower, 6g of frankincense, 6g of myrrh, 12g of Chinese clematis and 6g of liquorice;

or 6g of semen Impatientis, 12g of herba Lycopi, 15g of herba speranskiae tuberculatae, 12g of cortex Dictamni Radicis, 12g of rhizoma Sparganii, 12g of rhizoma Curcumae, 12g of herba Lycopodii, 6g of Olibanum, 6g of Myrrha, 15g of caulis Spatholobi, 12g of radix Achyranthis bidentatae and 3g of radix Glycyrrhizae.

Further, the plaster composition comprises the following raw materials:

30g of rhizoma cibotii, 20g of parasitism, 20g of eucommia ulmoides, 30g of dipsacus root, 15g of morinda officinalis, 10g of achyranthes bidentata, 10g of drynaria rhizome, 30g of semen cuscutae, 10g of vinegar rhizoma corydalis, 9g of ground beetle, 10g of earthworm, 10g of large-leaf gentian root, 10g of cortex acanthopanacis, 10g of radix angelicae pubescentis, 12g of poria cocos, 30g of coix seed, 10g of dried orange peel and 6g of fructus amomi;

or 10g of angelica sinensis, 10g of ligusticum wallichii, 10g of peach kernel, 10g of safflower, 18g of morinda officinalis, 30g of dipsacus root, 10g of cortex acanthopanacis, 10g of rhizoma zingiberis, 6g of frankincense, 6g of myrrh, 10g of radix cyathulae, 10g of rhizoma corydalis, 10g of caulis spatholobi, 9g of papaya, 10g of clematis root, 12g of poria, 30g of coix seed, 10g of dried orange peel, 10g of lycopodium clavatum and 10g of luffa.

Or 24g of astragalus, 10g of angelica, 10g of ligusticum wallichii, 10g of white peony root, 10g of rehmannia glutinosa, 10g of codonopsis pilosula, 10g of fructus lycii, 10g of pulp of dogwood fruit, 15g of morinda officinalis, 10g of cortex acanthopanacis, 10g of polygonum multiflorum, 12g of poria, 10g of bighead atractylodes rhizome, 10g of gentiana macrophylla, 10g of radix sileris, 10g of rhodiola rosea, 10g of earthworm, 10g of radix salviae miltiorrhizae, 10g of pericarpium citri reticulatae and 10g of radix aucklandiae;

or 9g of cassia twig, 10g of white peony root, 10g of papaya, 15g of radix clematidis, 10g of lycopodium clavatum, 10g of loofah sponge, 15g of kadsura pepper stem, 10g of rhizoma zingiberis, 10g of rhizoma corydalis, 9g of ground beetle, 10g of earthworm, 10g of cortex acanthopanacis, 10g of radix cyathulae, 10g of radix angelicae pubescentis, 10g of radix sileris, 12g of poria cocos, 30g of coix seed, 20g of red bean, 10g of dried orange peel and 10g of fructus aurantii.

Compared with the prior art, the technical scheme provided by the embodiment of the application has at least the following advantages:

1. the invention discloses a series of Chinese medicaments which can take an oral preparation as a main treatment for femoral head necrosis and are compound preparations. The external plaster can promote capillary vessel regeneration, accelerate the metabolism and absorption of necrotic bone, promote the growth of new bone and achieve the effect of repairing femoral head by taking different dialectical medicines, especially taking the bone slice composition as the main component and taking the fumigation method, the traditional Chinese medicine introducing method and the medicated bath method as the auxiliary component.

2. The Chinese medicine preparation is a compound prescription, and has the advantages that the bone tablet composition is mainly taken orally, the decoction is applied in a dialectical mode in the acute cases, and the tablets and pills are added slowly in the gradual cases, so that the kidney tonifying and bone regeneration are realized, the world problem of capillary vessel regeneration in a necrosis area is solved, and the bone absorption, crawling substitution and regeneration of a brand-new femoral head are promoted.

3. The traditional Chinese medicine preparation has the characteristics of no pain, low cost, short treatment course, quick recovery and no recurrence after healing. The surgical operation is not needed, the trauma of hip joint replacement operation is avoided, and the difficult problem of femoral head necrosis is solved.

Detailed Description

For the purposes of making the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present application based on the embodiments herein.

Unless specifically indicated otherwise, the various raw materials, reagents, instruments, equipment, and the like used in this application are commercially available or may be prepared by existing methods.

The application provides a series of traditional Chinese medicines taking an oral preparation as a main treatment for femoral head necrosis, which takes an oral bone slice composition as a main treatment, and takes a medicated bath composition, a fumigation composition and a plaster composition as auxiliary treatment, wherein the bone slice composition can be used independently or can be matched with the three compositions. Through the home transfer, the teacher transfer and the national transfer of nearly three hundred years, seven-generation traditional Chinese medicine people use heart blood and sweat to coagulate into a therapy for treating femoral head necrosis by using Mahalanobis traditional Chinese medicine, and the therapy is carried out by a forward method, innovatively developed and authentic.

The principles and features of the present invention are described below in connection with the following examples, which are set forth to illustrate, but are not to be construed as limiting the scope of the invention. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.

Example 1

The embodiment provides a series of traditional Chinese medicines mainly used for treating femoral head necrosis by taking an oral preparation, which comprises the following raw materials: 15g of drynaria rhizome, 6g of deer-horn glue, 3g of dragon's blood, 12g of grassleaf sweelflag rhizome, 15g of twotooth achyranthes root, 15g of cortex acanthopanacis, 12g of himalayan teasel root, 12g of Chinese angelica, 12g of eucommia bark, 12g of safflower, 15g of red sage root, 15g of suberect spatholobus stem, 9g of frankincense, 9g of myrrh and 6g of liquorice.

The medicament of this example is a bone plate, each 0.3g. The usage method is as follows: 3-5 g for adults each time, 3 times a day, and warm boiled water. It is administered 2 hours after meal.

The medicament of the embodiment takes rhizoma drynariae and deer-horn glue as main medicaments, has bitter and warm taste of the rhizoma drynariae, is nontoxic, enters liver and kidney channels, tonifies kidney, strengthens bones, benefits marrow, relieves pain, and eliminates toxic gases in bones. Deer horn glue can tonify kidney and nourish essence and blood. The two are combined together, so as to tonify kidney, strengthen bone, relieve pain, promote tissue regeneration, strengthen waist and knee, treat flaccidity of bone and promote regeneration of new bone. Dragon's blood is Gan Xianping in nature, nontoxic, free from blood stasis, capable of removing blood stasis, promoting tissue regeneration, dredging meridians and relieving pain, and is a holy medicine for regulating blood. The grassleaf sweelflag rhizome is warm and nontoxic, aromatic and has the effects of inducing resuscitation, promoting qi and blood circulation, clearing and activating the channels and collaterals, removing five strains and seven injuries and dredging twelve meridians. The medicines are combined together to play the roles of tonifying kidney, replenishing essence, and relieving pain, so as to relieve bone poisoning and qi, accelerate metabolism, promote the absorption of dead bones and promote new bone hyperplasia.

Example 2

The embodiment provides a series of traditional Chinese medicines mainly used for treating femoral head necrosis, which are bone slices, each slice weighing 0.3g, and comprise the following raw materials:

12g of grassleaf sweelflag rhizome, 12g of ground beetle, 3g of grass cream, 15g of suberect spatholobus stem and 3g of calcined native copper.

The bone chips of the embodiment have the effects of promoting blood circulation to remove blood stasis, promoting qi circulation and dredging collaterals.

The usage method is as follows: 3g for adults and children. The wine is taken 3 times a day with 15g of yellow wine 2 hours after meals, and no water is needed within half an hour after taking the medicine.

Wherein, the grassleaf sweelflag rhizome is pungent and warm and nontoxic, has the main effects of inducing resuscitation, eliminating phlegm, regulating qi and activating blood, dispelling wind and eliminating dampness. Eupolyphaga Seu Steleophaga has the effects of dispersing blood stasis, removing stasis, dredging collaterals, and treating fracture and reunion of fractured bones. Baicao cream is pungent and mainly used for dispersing, stopping bleeding and removing blood stasis, detumescence and resolving stagnation, and can be used for dispersing yin and congealing Chen Ju. Astragalus root has the actions of warming and tonifying deficiency and qi, strengthening tendons and bones, and is indicated for all syndromes of qi deficiency and blood deficiency. The medicinal yellow wine is used as a guide, and has the effects of promoting blood circulation and promoting the efficacy of the medicine, and strengthening the effects of promoting blood circulation and relieving pain. The medicines are combined to play roles of promoting blood circulation, removing blood stasis, promoting tissue regeneration, promoting qi circulation, removing obstruction in collaterals, tonifying kidney and strengthening bones, and can improve and reconstruct the blood circulation of the femoral head so as to facilitate the formation of new bones.

Example 3

The embodiment provides a series of traditional Chinese medicines mainly used for treating femoral head necrosis, which are bone slices, each tablet weighing 6g, and comprise the following raw materials:

18g of astragalus, 12g of fleece-flower root, 12g of pangolin scales, 9g of angelica dahurica, 15g of dragon's blood, 18g of drynaria rhizome, 3g of sappan wood, 6g of suberect spatholobus stem, 3g of gentiana macrophylla, 3g of achyranthes root and 3g of costustoot.

The efficacy of the composition is: to replenish qi and nourish blood, dredge collaterals and remove arthralgia. The usage method is as follows: each time, 2 pills, 6g each pill, are taken 2-3 times daily.

In the formula, astragalus root is sweet in temperature and tonifying qi as a main medicine; fleece-flower root, radix polygoni multiflori is sweet and bitter in taste, can tonify liver and kidney, benefit essence and blood, and strengthen tendons and bones; squama Manis is salty and cold entering liver meridian, dispelling pathogenic wind, dredging collaterals, relieving arthralgia, and relieving spasm; radix angelicae Xin Wenqi is aromatic, and has effects of dispelling pathogenic wind, eliminating dampness, inducing resuscitation and relieving pain. The medicines are combined together to play the roles of tonifying qi and nourishing blood, dredging collaterals and removing arthralgia, and inducing resuscitation and relieving pain.

Example 4

The embodiment provides a series of traditional Chinese medicines mainly used for treating femoral head necrosis, which are bone slices, each slice weighing 0.3g, and comprise the following raw materials:

3g of long-noded pit viper, 9g of radix angelicae pubescentis, 9g of peach kernel, 6g of divaricate saposhnikovia root, 6g of ginseng, 9g of safflower, 9g of twotooth achyranthes root, 3g of chicken's gizzard-skin, 9g of amur corktree bark, 9g of rhizoma atractylodis, 18g of coix seed, 16g of radix clematidis and 6g of cassia twig.

The efficacy of the composition is: dispelling wind and cold, promoting diuresis and removing obstruction in collaterals, promoting blood circulation for removing blood stasis, strengthening body resistance and consolidating constitution.

The usage method is as follows: 3-5 g each time, 3 times a day.

In the recipe, the long-noded pit viper flavor is sweet and salty in nature and warm in nature, and can penetrate bones and search wind; du Huo is pungent and warm in nature and can dispel wind and dispel dampness, so it is an essential herb for relieving arthralgia and pain. Peach kernel, semen Persicae, bitter and sweet in taste, has a flat nature, enters heart and liver meridians, and is the winner for removing blood stasis and promoting blood production, and "treating wind first treats blood and blood goes out of wind automatically"; has the effects of preventing flavor, warming, dispelling pathogenic wind, relieving spasm, eliminating dampness, and relieving arthralgia. Ginseng is sweet in taste, and can tonify primordial qi, benefit qi and promote the production of body fluid. The medicines are combined together to play the roles of dispelling wind and eliminating dampness, promoting blood circulation and removing arthralgia, and tonifying qi and consolidating constitution.

The inventor of the invention is the old traditional Chinese medicine of the fatal femoral head necrosis, and the traditional Chinese medicine and the using method of the traditional Chinese medicine are summarized through the clinical curative effects of tens of thousands of femoral head necrosis.

Specifically, the medicine is used for treating according to syndrome differentiation.

1. Qi stagnation and blood stasis type

The specific expression is that the pain of the hip is distending pain or stabbing pain, the pain is fixed and not moved, the pain is aggravated after sitting for a long time, the pain is relieved after proper movement, but the pain can be caused by the relatively large passive or active movement of the hip joint in any direction, the tongue is slightly dark, and the pulse is deep and astringent. It should promote qi circulation and remove blood stasis. The second composition is taken orally. If distending pain is the main ingredient, the decoction for guiding qi downward and activating blood circulation is taken together; if the stinging pain is the main aspect, the decoction is taken together with the decoction for restoring normal function and activating blood.

2. Qi deficiency and blood stasis type

The specific expression is that the pain of the hip joint is not severe, or only slight pain is felt. Mainly, the functional disorder is that the serious people can not move freely in any direction, even bed or crutch walking is sometimes accompanied by slight muscular atrophy, the complexion is lusterless, the people are less qi and lazy to talk, the tongue is dark red, and the tongue coating is thin and white. It should be effective in invigorating qi and promoting blood circulation. The second composition and/or the third composition are taken orally.

3. Deficiency of both qi and blood

The specific manifestation is that qi and blood circulation is unsmooth, muscles and bones are malnourished, so that the muscles are atrophic, blood supply is insufficient after activity, pain is aggravated, and the pain is not obvious when the rest is carried out. Pale complexion due to blood deficiency, pale lips and nails, shortness of breath and hypodynamia due to qi deficiency. A weak pulse, a pale tongue with thin and white coating, both of which are the symptoms of qi and blood deficiency. It should be used for invigorating qi and nourishing blood. The third composition is taken orally. Spleen is the source of qi and blood, and if stomach is not good, spleen-invigorating and stomach-nourishing herbs should be combined according to the syndrome.

4. Kidney yang deficiency type

The specific manifestations are combined with impotence, cold womb, dysmenorrhea, amenorrhea, aversion to cold, cold limbs and edema of lower limbs. Dull pain in the hip, aggravated after movement, severe cold, aversion to cold, cold limbs, soreness and weakness of the waist and knees, lameness, listlessness, pale complexion or black, or impotence, complete valley diarrhea, edema, severe under the waist, pale tongue with white coating, and deep and weak pulse. It should warm and tonify kidney yang. The first composition (bone-tonifying tablet) should be taken orally for treating edema of lower limbs due to excessive yang deficiency, and should be combined with yang-warming, spleen-invigorating, dampness-removing and repercussive herbs.

5. Deficiency of both liver and kidney

The specific characteristics are that the pain of the hip is lighter, the pain is aggravated during the activity, and the pain is relieved after the rest. Suffering from amyotrophy of limbs, spontaneous perspiration or night sweat, amnesia, insomnia, dysphoria with feverish sensation in the chest, red tongue with little coating, and thready and rapid pulse. It should nourish liver and kidney, nourish blood and harmonize blood. The third composition is taken orally and combined with liver and kidney tonifying products such as dried rehmannia root, cornus officinalis, wolfberry fruit and the like.

6. Yang deficiency type calendar

The joint diseases are named as joint diseases because the joint is hard and can not stretch due to the fact that the femoral head necrosis does not collapse, the acetabular necrosis is combined, the joint clearance is narrowed, the dysfunction is obvious, and the pain is light and heavy, and swelling and deformation of other joints can be involved. Most patients belong to the stable period, pale complexion, dizziness, tinnitus, aversion to cold, spontaneous perspiration, epidemic soft waist and leg, clear and long urine, frequent nocturia, incomplete urine, deep and weak pulse, pale tongue with thin and white coating. It should warm yang, replenish qi, dispel cold, dispel dampness and remove arthralgia. The fourth composition is taken orally.

7. Damp-heat type

The specific symptoms are obesity, hip joint pain, exopathogens feeling or symptoms aggravated or uncomfortable after fumigation and bath treatment by adopting traditional Chinese medicines, dysphoria, heavy lower limbs, red tongue, yellow and thick coating, wiry and slippery or rapid pulse. It should be indicated for clearing heat and promoting diuresis, activating blood and removing obstruction in collaterals. Orally taking the second composition, and combining with the dampness-removing and meridian-dredging products such as phellodendron bark, coix seed, papaya, achyranthes root and the like.

8. Children's epiphyseal necrosis

The specific expression is that the children are not painful in early stage of the illness. The attention of parents is only drawn when the infant suddenly finds out that the infant has overactivity and then has lameness and pain. At this time, the X-ray examination generally reaches stages II to III. When the test of the 4-type test is positive, most infants suffer from thigh and hip muscle atrophy, limb shortness and double-sided shortness, and the toddler gait is seen.

The infant viscera are tender, the bone qi is not formed, and the viscera qi is clear, so that the infant femoral head epiphyseal necrosis is different from the adult, and has the characteristic of easy rehabilitation. In clinic, it can treat liver and kidney deficiency and qi and blood deficiency by differentiation. It should be used for nourishing liver and kidney, and is combined with Corni fructus, fructus Ligustri Lucidi, fructus Lycii, and rhizoma Cibotii. And a third composition for supplementing qi and nourishing blood.

Example 5

The embodiment provides a series of traditional Chinese medicine preparations mainly used for treating femoral head necrosis, which are medicinal bath compositions, and comprise the following raw materials:

18g of drynaria rhizome, 12g of garden balsam stem, 12g of lycopodium clavatum, 6g of semen Impatientis, 12g of large-leaved gentian, 12g of divaricate saposhnikovia root, 6g of lithospermum, 12g of herba lycopi, 15g of suberect spatholobus stem, 12g of Chinese angelica, 12g of safflower and 6g of liquorice.

The traditional Chinese medicine preparation of the embodiment is used for treating kidney deficiency and toxin stasis (mainly hormone), has medical history of using hormone medicines, and can be used for single-side or double-side sequential morbidity and hip joint dull pain. For kidney tonifying, bone growing, body resistance strengthening and toxin removing. Therefore, the method uses rhizoma drynariae to tonify kidney, replenish essence, activate blood, remove blood stasis and detoxify toxin in bones; herba speranskiae tuberculatae has effects of promoting blood circulation, removing blood stasis, dispelling pathogenic wind and removing dampness; herba Lycopodii has effects of dispelling pathogenic wind, removing dampness, relieving rigidity of muscles and activating collaterals; semen Impatientis has effects of promoting blood circulation, removing blood stasis, and softening hard mass.

Example 6

The embodiment provides a series of traditional Chinese medicine preparations mainly used for treating femoral head necrosis, which are medicinal bath compositions, and comprise the following raw materials:

6g of garden balsam seed, 12g of common burreed rhizome, 12g of zedoary, 12g of garden balsam stem, 12g of common clubmoss herb, 12g of honeysuckle stem, 9g of Chinese taxillus twig, 9g of white paeony root, 9g of szechuan lovage rhizome, 9g of Chinese angelica, 9g of safflower, 12g of Chinese clematis and 6g of liquorice.

The traditional Chinese medicine preparation in the embodiment treats qi stagnation and blood stasis (mainly trauma) and has obvious history of acute or chronic injury. Frequently, the disease is developed on one side, and the pain is usually seen by needling. For activating blood, resolving stasis, promoting qi and dredging collaterals. The semen Impatientis is used for promoting blood circulation to remove blood stasis and softening hard masses; rhizoma sparganii and rhizoma curcumae break blood and promote qi circulation, remove food retention and relieve pain; speranskia Tuberculata has effects of promoting blood circulation, removing blood stasis, dispelling pathogenic wind and removing dampness.

The methods of using the medicated bath compositions of examples 5 and 6 were as follows:

the medicines of the embodiment 5 or the embodiment 6 are put into a medicinal bath barrel for soaking for 1 hour with 2000 g (10 times), then boiled for 1 hour with the hard gas of a boiler, the medicinal liquid is input into each bathtub (the dosage can be increased or decreased according to the number of people or the quantity of the bathtub) through a liquid medicine placing pipeline, then cooled and heated water is added for temperature adjustment to 40 ℃, and the water quantity is proper for patients to level the chest in the bidet. Soaking for 40 min each time, removing medicinal liquid after bathing, sterilizing, bathing with medicinal liquid for the second person, and cleaning body with clear water after bathing.

Notice that: (1) the bath is forbidden for patients with heart disease, liver disease, venereal disease, skin disease and weak constitution. (2) Maintaining ventilation in the bath room. (3) The water temperature is not easy to overheat, so as to avoid excessive sweating and deficiency. (4) After the bath, the user should pay attention to not feel wind-cold.

By combining the embodiment 5 and the embodiment 6, the ischemic necrosis of the femoral head belongs to the category of 'bone erosion' in traditional Chinese medicine, and is caused by deep channeling of body deficiency and toxin evil, cold and heat phase pulsation, long-lasting and internal-known, kidney-yang deficiency, qi stagnation and blood stasis, failure of liver nourishing due to kidney deficiency, failure of blood nourishing due to liver deficiency, qi and blood failing to nourish, blood stasis and meridian, and bone and tendons wither and bone withered marrow empty. According to the theory of traditional Chinese medicine and the characteristics of ischemic necrosis of femoral head, the inventor of the invention applies the Chinese herbal medicine medicated bath method, and after long-time whole body soaking, medicines can permeate into muscles, ligaments and bones from the outside to the inside through fur and acupoints so as to dredge the striae and open the hair orifices, thereby achieving the effects of warming channels to eliminate evil, dredging channels and activating collaterals, activating blood circulation to remove blood stasis, recuperating qi and blood and improving local functions and nutrition states.

The inventor divides ischemic necrosis of femoral head into three stages and performs diagnosis and treatment based on the differences of kidney-yang deficiency, kidney-yin deficiency and yin-yang deficiency, and the characteristics of stagnant toxin and qi stagnation and blood stasis.

Example 7

The embodiment provides a series of traditional Chinese medicines mainly used for treating femoral head necrosis by taking an oral preparation as a fumigating composition, which comprises the following raw materials:

18g of drynaria rhizome, 12g of zedoary, 12g of grassleaf sweelflag rhizome, 6g of cocklebur fruit, 12g of cortex acanthopanacis, 12g of apocynum venetum, 12g of common burreed rhizome, 12g of sappan wood, 12g of Chinese angelica, 12g of red paeony root, 9g of safflower, 6g of frankincense, 6g of myrrh, 12g of Chinese clematis and 6g of liquorice.

The recipe is for treating kidney deficiency and toxic stasis, has the medical history of hormone medicine, and may be used in treating single side or double side diseases and dull pain in hip joint. For kidney tonifying, bone growing, body resistance strengthening and toxin removing.

In the formula, rhizoma drynariae is used for tonifying kidney, promoting blood circulation, removing blood stasis, relieving toxin in bones, and rhizoma curcumae for breaking blood, promoting qi circulation, removing food retention and relieving pain; rhizoma Acori Graminei has effects of inducing resuscitation, dredging twelve channels, and removing toxic substances; fructus Xanthii can induce sweat to induce resuscitation, dispel wind and dispel dampness.

Example 8

The embodiment provides a series of traditional Chinese medicines mainly used for treating femoral head necrosis by taking an oral preparation as a fumigating composition, which comprises the following raw materials:

6g of garden balsam seed, 12g of herba lycopi, 15g of garden balsam stem, 12g of dittany bark, 12g of rhizoma sparganii, 12g of rhizoma curcumae, 12g of lycopodium clavatum, 6g of frankincense, 6g of myrrh, 15g of suberect spatholobus stem, 12g of radix achyranthis bidentatae and 3g of liquorice.

The treatment of the recipe is that qi stagnation and blood stasis type: there was a clear history of acute and chronic injury, with the Chang Shan side onset, mainly tingling. The treatment is as follows: promoting blood circulation, removing blood stasis, promoting qi circulation, and dredging collaterals.

The semen Impatientis is used for promoting blood circulation to remove blood stasis and softening hard masses; herba Lycopi has effects of promoting blood circulation, removing blood stasis and relieving pain; herba speranskiae tuberculatae has effects of promoting blood circulation, removing blood stasis, dispelling pathogenic wind and removing dampness; cortex Dictamni Radicis has effects of clearing heat and detoxicating, eliminating dampness and dispelling pathogenic wind.

The methods of using the drugs of example 7 or example 8 are as follows:

putting a dose of medicine (250 g) into a cloth bag, sewing, putting into clear water for soaking, putting into a steamer, steaming for 10-15 minutes after boiling, and keeping the temperature of the medicine bag at about 40 ℃. A piece of plastic cloth is laid on the bed, the patient lies on the back on the plastic cloth, the medicine bag is placed on the affected part, if the medicine bag is overheated, the medicine bag can not be contacted with the skin, steam is firstly used for fumigation, the medicine bag is placed on the skin when the temperature is proper, and the heat release water bag is arranged on the medicine bag to keep the temperature constant, and then the medicine bag is wrapped by the plastic cloth to prevent the excessive heat loss and the pollution to clothes. Steaming for 60 min, and steaming the medicinal bag for use. Each dose was used 8 times a day, 1 time a day.

Notice that: (1) the temperature of the medicine bag is not overheated so as not to hurt the skin by ironing; (2) when steaming, a certain temperature and time are kept; (3) in summer, the medicine is prevented from deterioration and invalidation, and can be stored in a refrigerator after being used.

The fumigation method is a method for treating diseases by soaking Chinese herbal medicines in a medicinal bag, steaming, and then placing in affected part. The inventor improves the traditional steaming and heating method through years of practice, and is applied to treating ischemic necrosis of femoral head, thereby obtaining satisfactory effect.

Treatment based on syndrome differentiation: clinically divided into kidney deficiency and stasis type treatment for regulating qi stagnation and blood stasis

Example 9

The embodiment provides a series of traditional Chinese medicines mainly used for treating femoral head necrosis by taking an oral preparation, which is a plaster composition and is dialectical to deficiency of liver and kidney, and comprises the following raw materials:

30g of rhizoma cibotii, 20g of parasitic, 20g of eucommia ulmoides, 30g of dipsacus root, 15g of morinda officinalis, 10g of achyranthes bidentata, 10g of drynaria rhizome, 30g of semen cuscutae, 10g of vinegar rhizoma corydalis, 9g of ground beetle, 10g of earthworm, 10g of large-leaf gentian root, 10g of cortex acanthopanacis, 10g of radix angelicae pubescentis, 12g of poria cocos, 30g of coix seed, 10g of dried orange peel and 6g of fructus amomi.

In this recipe, kidney-essence accumulation is the main part of kidney to promote bone marrow production, kidney deficiency, empty waist and insufficient marrow and sea, so soreness and weakness of waist and knees, weakness of both lower limbs and increased activity occur. And (5) a rhizoma cibotii. Herba Taxilli, eucommiae cortex, radix Dipsaci and radix Morindae officinalis are used as principal drugs for tonifying kidney and strengthening bones, achyranthis radix, rhizoma Drynariae and cortex Acanthopanacis are used as ministerial drugs, and cooperate with the principal drugs to increase curative effect, so that the aim of removing the disease from the medicine is achieved, and the gentiana macrophylla, radix Angelicae Pubescentis and Coicis semen are used as adjuvant drugs to increase the curative effect of the principal drugs and prevent adverse reaction in treatment. Poria, pericarpium Citri Tangerinae and fructus Amomi are used as guiding drug for harmonizing the drugs.

Example 10

The embodiment provides a series of traditional Chinese medicines mainly used for treating femoral head necrosis by taking an oral preparation, which is a plaster composition and is dialectical in terms of qi stagnation and blood stasis, and comprises the following raw materials:

10g of angelica sinensis, 10g of ligusticum wallichii, 10g of peach kernel, 10g of safflower, 18g of morinda officinalis, 30g of dipsacus root, 10g of cortex acanthopanacis, 10g of rhizoma zingiberis, 6g of frankincense, 6g of myrrh, 10g of radix cyathulae, 10g of vinegar rhizoma corydalis, 10g of caulis spatholobi, 9g of papaya, 10g of clematis root, 12g of poria cocos, 30g of coix seed, 10g of dried orange peel, 10g of lycopodium clavatum and 10g of luffa.

In the recipe, chinese angelica, ligusticum chuanxiong, peach kernel, safflower, spatholobus stem, frankincense and myrrh are monarch drugs, promote blood circulation to remove blood stasis, dredge collaterals and relieve pain, turmeric, radix cyathulae, cortex acanthopanacis and rhizoma corydalis are ministerial drugs, promote blood circulation and relieve pain, and the monarch drugs exert curative effects, so that the purposes of removing diseases by the drugs are achieved, lycopodium clavatum, luffa, and tendon extension and blood circulation are achieved, the blood circulation and relieving pain are adjuvant drugs, the dried orange peel and poria cocos are spleen-strengthening, dampness-removing and qi-regulating drugs, and adverse reactions in monarch drugs are prevented.

Example 11

The embodiment provides a series of traditional Chinese medicines mainly used for treating femoral head necrosis by taking an oral preparation, which is a plaster composition and is dialectical to deficiency of both qi and blood, and comprises the following raw materials:

24g of astragalus, 10g of angelica, 10g of ligusticum wallichii, 10g of white peony root, 10g of rehmannia glutinosa, 10g of codonopsis pilosula, 10g of fructus lycii, 10g of pulp of dogwood fruit, 15g of morinda officinalis, 10g of cortex acanthopanacis, 10g of polygonum multiflorum, 12g of poria cocos, 10g of bighead atractylodes rhizome, 10g of large-leaf gentian root, 10g of radix sileris, 10g of rhodiola rosea, 10g of earthworm, 10g of radix salviae miltiorrhizae, 10g of pericarpium citri reticulatae and 10g of elecampane.

In this recipe, qi is the general and blood is the mother of qi, and qi exuberance results in smooth blood circulation and direct arrival at the affected area, thus achieving the purpose of removing the medicine. The Chinese medicinal composition is characterized in that the radix codonopsitis, the astragalus and the rhodiola root in the recipe can tonify qi and invigorate the spleen, and the Chinese angelica, the ligusticum chuanxiong, the white paeony root, the prepared rhizome of rehmannia, the red sage root and the polygonum multiflorum are used as ministerial drugs for replenishing blood and activating blood circulation, so as to achieve the purposes of promoting blood circulation and dispersing blood stasis, the large-leaf gentian root, the radix sileris, the morinda root, the cortex acanthopanacis and the earthworm are used as adjuvant drugs for dispelling wind and dispelling cold and removing dampness, and the monarch drugs and the ministerial drugs are synergistically enhanced to exert the curative effect, and the costustoot and the dried orange peel regulate qi and harmonize the stomach. Preventing adverse side effects of the medicine, and is used for guiding the medicine.

Example 12

The embodiment provides a series of traditional Chinese medicines mainly used for treating femoral head necrosis by taking an oral preparation, which is a plaster composition and is dialectically dampness evil and arthralgia, and comprises the following raw materials:

9g of cassia twig, 10g of white peony root, 10g of papaya, 15g of radix clematidis, 10g of lycopodium clavatum, 10g of loofah sponge, 15g of kadsura pepper stem, 10g of rhizoma zingiberis, 10g of rhizoma corydalis, 9g of ground beetle, 10g of earthworm, 10g of cortex acanthopanacis, 10g of radix cyathulae, 10g of radix angelicae pubescentis, 10g of radix sileris, 12g of poria cocos, 30g of coix seed, 20g of red bean, 10g of dried orange peel and 10g of fructus aurantii.

In the recipe, spleen is the acquired root, spleen is used for four limbs, spleen is used for transporting and transforming water dampness and cereal essence, spleen deficiency is used for transporting and transforming, water dampness is stopped internally, dampness evils disturb spleen and other symptoms, poria cocos, semen coicis, red bean, cassia twig, pawpaw and radix clematidis are used for strengthening spleen and promoting diuresis, relaxing tendons and activating collaterals, the recipe is used as monarch drug, rhizoma corydalis, ground beetle, earthworm, radix cyathulae and cortex acanthopanacis are used for removing blood stasis and dredging collaterals, and relieving pain, the monarch drug is used as ministerial drug, the curative effect is achieved by assisting the monarch drug to reach the purpose of removing the disease, lycopodium clavatum, luffa and kadsura pepper stem are used for dispelling cold, activating collaterals and relieving pain are used as adjuvant drugs, the monarch drug is assisted to better exert, and fructus aurantii and dried orange peel are used as messenger drugs, so that different degrees of side effects of monarch drug in treatment are prevented.

Test examples

1-results of pharmacodynamic study:

(1) effects on inflammation. The bone plate composition (bone supplementing plate) provided in examples 1-4 has a clear anti-inflammatory effect, and has a strong inhibition effect on both rat plantar egg white inflammation and mouse ear xylene inflammation.

(2) Effects on pain. The bone slice composition (bone supplementing slice) has obvious analgesic effect and obvious inhibiting effect on torsion reaction caused by pain due to intraperitoneal injection of acetic acid into mice.

(3) The effect on the yang deficiency syndrome of mice. The bone slice composition (bone supplementing slice) has the functions of changing the atrophy of sexual organs and the weakening of autonomous activities of 'yang deficiency syndrome' caused by hormone, and obviously improving the hypoxia tolerance of the brain of a mouse. Has no obvious effect on weight loss and body temperature drop.

(4) Effects on immune function. The bone slice composition (bone supplementing tablet) can enhance immunity. Has effects in enhancing phagocytic function of reticuloendothelial system, including eliminating pathogen, scavenging foreign matter, and scavenging decay cells. Not only cellular immunity, but also humoral immunity and nonspecific immunity.

(5) Effect on experimental osteoporosis in rats. The bone slice composition (bone supplementing slice) has obvious improvement on pathological changes of rat osteoporosis caused by retinoic acid, such as femur density reduction, bone calcium and phosphorus content reduction, femur head bone size Liang Bianxi and the like, and can increase the fatigue resistance of animals and improve the overall condition of the animals.

2-toxicology study results:

(1) acute toxicity experiments. Bone plate composition (bone supplementing plate) mice were perfused with gastric LD. No death or adverse reaction is found in the crude drug with the weight of more than 84 g/kg (210 times of the clinical dosage).

(2) Long-term toxicity experiments. The bone plate composition (bone supplementing plate) was continuously administered by intragastric administration at 3 doses (20 g, 10g, 1g crude drug/kg body weight) for 3 months without death and adverse reaction. Electrocardiogram, blood convention and GOT, GPT, BUN are all in normal physiological ranges, and the organs such as heart, liver, spleen, lung, kidney, large intestine, adrenal gland and the like are generally observed and examined under the microscope, so that toxic pathological changes are avoided, and toxicity experiments show that the bone slice composition (bone supplementing slice) is safe in clinical use.

3-quality criteria and preliminary stability:

according to the chemical composition and the formulation characteristics of the medicine contained in the prescription of the bone slice composition (bone supplementing slice), a thin layer chromatography identification method of glycine in dragon's blood, frankincense and deer-horn gum and a high performance liquid chromatography determination method of naringin in drynaria are prepared, and a constant temperature sample retention observation method is adopted to carry out preliminary investigation on the stability of the Markov bone slice (bone supplementing slice) for 3 months, so that the stability of the medicine property is proved.

4-efficacy analysis:

the repair process of femoral head necrosis is slow, generally takes years, to late femoral head necrosis with osteoarthropathy, or irreversible degenerative joint disability. The traditional Chinese medicine therapy of the inventor is confirmed by a large number of clinical practices. Has the main effects of promoting the absorption of dead bones, accelerating the proliferation of new bones and obviously repairing damaged bones. The capacity and speed of necrotic bone absorption, bone repair and reconstruction in treatment are related to various factors, and besides age and emotional changes of patients outside treatment, the pure administration of drugs is also closely related to other auxiliary therapies. The time and completeness of the bone repair and reconstruction are also directly related to the size of the necrosis range. The absorption of dead bone can be seen from X-ray films in general from 3 months to half a year of treatment, and in some cases 40 days of treatment the top half moon dead bone is reduced from 3.8cm X1.9cm to 3cm X1.5cm. There were cases where the 2-half month top center dead bone was reduced from 4.0cm x2.5cm to 3.4cm x1.0cm. Many patients have significantly improved symptoms and functions in one or two months or less after treatment, and have absorbed and cracked dead bones after treatment, have had changes in capsules, have had free bone fragments filled, have had dead bone fragments absorbed, have had collapse and deform, and have no longer collapsed as seen from X-ray films. The above results occur mainly because the type of necrosis is different from the timing of treatment and should be considered as repair in general. Can improve symptoms and functions through repair. Many patients recover normal work after 1-2 years of treatment, and some cases follow-up for 15-20 years without recurrence, and the curative effect is stable.

The foregoing is merely a specific embodiment of the application to enable one skilled in the art to understand or practice the application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (8)

1. A series of Chinese medicinal preparation for treating femur head necrosis comprises bone slice composition;

or comprises a bone slice composition, a medicated bath composition, a steaming and steaming composition or a plaster composition which are matched with the bone slice composition for use;

the bone slice composition comprises a first composition with the effects of tonifying kidney and strengthening bones, a second composition with the effects of activating blood and dissolving stasis, a third composition with the effects of tonifying qi and nourishing blood, and a fourth composition with the effects of dispelling wind and dispelling cold.

2. The series of traditional Chinese medicine preparations for mainly treating femoral head necrosis according to claim 1, wherein the first composition comprises the following raw materials:

15g of drynaria rhizome, 6g of deer-horn glue, 3g of dragon's blood, 12g of grassleaf sweelflag rhizome, 15g of twotooth achyranthes root, 15g of cortex acanthopanacis, 12g of himalayan teasel root, 12g of Chinese angelica, 12g of eucommia bark, 12g of safflower, 15g of red sage root, 15g of suberect spatholobus stem, 9g of frankincense, 9g of myrrh and 6g of liquorice.

3. The series of traditional Chinese medicine preparations for mainly treating femoral head necrosis according to claim 1, wherein the second composition comprises the following raw materials:

12g of grassleaf sweelflag rhizome, 12g of ground beetle, 3g of grass cream, 15g of suberect spatholobus stem and 3g of calcined native copper.

4. The series of traditional Chinese medicine preparations for mainly treating femoral head necrosis according to claim 1, wherein the third composition comprises the following raw materials:

18g of astragalus, 12g of fleece-flower root, 12g of pangolin scales, 9g of angelica dahurica, 15g of dragon's blood, 18g of drynaria rhizome, 3g of sappan wood, 6g of suberect spatholobus stem, 3g of gentiana macrophylla, 3g of achyranthes root and 3g of costustoot.

5. The series of traditional Chinese medicine preparations for mainly treating femoral head necrosis according to claim 1, wherein the fourth composition comprises the following raw materials in parts by weight:

3g of long-noded pit viper, 9g of radix angelicae pubescentis, 9g of peach kernel, 6g of divaricate saposhnikovia root, 6g of ginseng, 9g of safflower, 9g of twotooth achyranthes root, 3g of chicken's gizzard-skin, 9g of amur corktree bark, 9g of rhizoma atractylodis, 18g of coix seed, 16g of radix clematidis and 6g of cassia twig.

6. The series of Chinese medicinal preparations for mainly treating femoral head necrosis according to any one of claims 1 to 5, wherein the medicated bath composition comprises the following raw materials:

18g of drynaria rhizome, 12g of garden balsam stem, 12g of lycopodium clavatum, 6g of semen Impatientis, 12g of large-leaved gentian, 12g of divaricate saposhnikovia root, 6g of lithospermum, 12g of herba lycopi, 15g of suberect spatholobus stem, 12g of Chinese angelica, 12g of safflower and 6g of liquorice;

or 6g of semen Impatientis, 12g of rhizoma sparganii, 12g of rhizoma curcumae, 12g of herba speranskiae tuberculatae, 12g of herba lycopodii, 12g of caulis lonicerae, 9g of herba taxilli, 9g of radix paeoniae alba, 9g of ligusticum chuanxiong, 9g of angelica sinensis, 9g of safflower, 12g of radix clematidis and 6g of liquorice.

7. The series of traditional Chinese medicine preparations for mainly treating femoral head necrosis according to any one of claims 1 to 5, wherein the steaming composition comprises the following raw materials:

18g of drynaria rhizome, 12g of zedoary, 12g of grassleaf sweelflag rhizome, 6g of cocklebur fruit, 12g of cortex acanthopanacis, 12g of apocynum venetum, 12g of common burreed rhizome, 12g of sappan wood, 12g of Chinese angelica, 12g of red paeony root, 9g of safflower, 6g of frankincense, 6g of myrrh, 12g of Chinese clematis and 6g of liquorice;

or 6g of semen Impatientis, 12g of herba Lycopi, 15g of herba speranskiae tuberculatae, 12g of cortex Dictamni Radicis, 12g of rhizoma Sparganii, 12g of rhizoma Curcumae, 12g of herba Lycopodii, 6g of Olibanum, 6g of Myrrha, 15g of caulis Spatholobi, 12g of radix Achyranthis bidentatae and 3g of radix Glycyrrhizae.

8. The series of traditional Chinese medicine preparations for mainly treating femoral head necrosis according to any one of claims 1 to 5, wherein the plaster composition comprises the following raw materials:

30g of rhizoma cibotii, 20g of parasitism, 20g of eucommia ulmoides, 30g of dipsacus root, 15g of morinda officinalis, 10g of achyranthes bidentata, 10g of drynaria rhizome, 30g of semen cuscutae, 10g of vinegar rhizoma corydalis, 9g of ground beetle, 10g of earthworm, 10g of large-leaf gentian root, 10g of cortex acanthopanacis, 10g of radix angelicae pubescentis, 12g of poria cocos, 30g of coix seed, 10g of dried orange peel and 6g of fructus amomi;

or 10g of angelica sinensis, 10g of ligusticum wallichii, 10g of peach kernel, 10g of safflower, 18g of morinda officinalis, 30g of dipsacus root, 10g of cortex acanthopanacis, 10g of rhizoma zingiberis, 6g of frankincense, 6g of myrrh, 10g of radix cyathulae, 10g of rhizoma corydalis, 10g of caulis spatholobi, 9g of papaya, 10g of clematis root, 12g of poria, 30g of coix seed, 10g of dried orange peel, 10g of lycopodium clavatum and 10g of luffa.

Or 24g of astragalus, 10g of angelica, 10g of ligusticum wallichii, 10g of white peony root, 10g of rehmannia glutinosa, 10g of codonopsis pilosula, 10g of fructus lycii, 10g of pulp of dogwood fruit, 15g of morinda officinalis, 10g of cortex acanthopanacis, 10g of polygonum multiflorum, 12g of poria, 10g of bighead atractylodes rhizome, 10g of gentiana macrophylla, 10g of radix sileris, 10g of rhodiola rosea, 10g of earthworm, 10g of radix salviae miltiorrhizae, 10g of pericarpium citri reticulatae and 10g of radix aucklandiae;

or 9g of cassia twig, 10g of white peony root, 10g of papaya, 15g of radix clematidis, 10g of lycopodium clavatum, 10g of loofah sponge, 15g of kadsura pepper stem, 10g of rhizoma zingiberis, 10g of rhizoma corydalis, 9g of ground beetle, 10g of earthworm, 10g of cortex acanthopanacis, 10g of radix cyathulae, 10g of radix angelicae pubescentis, 10g of radix sileris, 12g of poria cocos, 30g of coix seed, 20g of red bean, 10g of dried orange peel and 10g of fructus aurantii.