CN117405675B - Imaging device for hemagglutination inhibition test workstation - Google Patents
Imaging device for hemagglutination inhibition test workstation Download PDFInfo
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- CN117405675B CN117405675B CN202311713345.7A CN202311713345A CN117405675B CN 117405675 B CN117405675 B CN 117405675B CN 202311713345 A CN202311713345 A CN 202311713345A CN 117405675 B CN117405675 B CN 117405675B
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- 238000003384 imaging method Methods 0.000 title claims abstract description 44
- 230000035931 haemagglutination Effects 0.000 title claims abstract description 30
- 238000012360 testing method Methods 0.000 title claims abstract description 28
- 230000005764 inhibitory process Effects 0.000 title claims abstract description 19
- 230000023555 blood coagulation Effects 0.000 claims abstract description 64
- 238000001125 extrusion Methods 0.000 claims description 18
- 238000010211 hemagglutination inhibition (HI) assay Methods 0.000 claims description 9
- 238000002347 injection Methods 0.000 claims description 7
- 239000007924 injection Substances 0.000 claims description 7
- 230000007306 turnover Effects 0.000 claims description 2
- 230000009471 action Effects 0.000 abstract description 11
- 210000004369 blood Anatomy 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
- 238000000034 method Methods 0.000 description 8
- 230000008569 process Effects 0.000 description 6
- 206010018910 Haemolysis Diseases 0.000 description 5
- 230000015271 coagulation Effects 0.000 description 5
- 238000005345 coagulation Methods 0.000 description 5
- 230000008588 hemolysis Effects 0.000 description 5
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000005389 magnetism Effects 0.000 description 3
- 101710154606 Hemagglutinin Proteins 0.000 description 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
- 101710176177 Protein A56 Proteins 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000185 hemagglutinin Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000004523 agglutinating effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses an imaging device for a hemagglutination inhibition test workstation, which belongs to the technical field of hemagglutination tests and comprises a mounting frame, a pipetting device, a combined hemagglutination plate and a swinging device; the swinging equipment is arranged at the top of the mounting frame, the pipetting equipment is arranged between the half gear rings at the two sides, the middle part of the mounting frame is provided with a mounting plate, and the combined blood coagulation plate is arranged on the mounting plate; the bottom of the mounting plate is provided with an imaging plate, and a plurality of groups of imaging devices are arranged on the imaging plate; the pipetting device comprises a transverse frame, wherein vertical plates are arranged on two sides of the transverse frame, a mobile motor is arranged on each vertical plate, a track is fixedly arranged between mobile blocks on two sides, and walking devices are arranged on the tracks; the combined blood coagulation plate comprises a blood coagulation cup and a mounting base. The walking device and the combined blood coagulation plate can be swung under the action of the half gear ring and the swing gear, and the blood coagulation test can be imaged from multiple angles. Under the action of the moving motor, the rail and the walking equipment can integrally move transversely, so that the pipetting efficiency is further improved.
Description
Technical Field
The invention relates to the technical field of hemagglutination tests, in particular to an imaging device for a hemagglutination inhibition test workstation.
Background
Viruses with Hemagglutinin (HA) are capable of agglutinating human or animal erythrocytes, known as hemagglutination, which can be inhibited by corresponding antibodies, known as hemagglutination inhibition assays, a technique for determining antigens or antibodies. I.e., the original hemagglutination reaction is inhibited after the specific antibody or the specific antigen is added. At present, in the blood coagulation inhibition experiment process, PBS, chicken erythrocyte suspension, ab's solution, 4 units of antigen and the like are required to be added according to a certain sequence, so that pipetting operation is required to be continuously carried out.
The patent application with the publication number of CN116008271A discloses a blood coagulation inhibition auxiliary imaging device, and relates to the technical field of in-vitro diagnosis, and the blood coagulation inhibition auxiliary imaging device comprises: a housing, a first optical path and a second optical path disposed inside the housing; each path of light path comprises: the device comprises a light source, a mounting seat, a first reflecting mirror, a second reflecting mirror and an imaging device; the light source is arranged in the shell, faces the mounting seat and is used for mounting the reaction plate; the first reflector is arranged above the mounting seat, the first reflector and the second reflector are arranged oppositely, and the first reflector and the second reflector are both reflectors with preset angles; the imaging device is arranged above the second reflecting mirror. Solves the problem that the detection result is deviated due to the limitation of the method of rotating the reaction plate by doctors in the prior art.
However, in the above-disclosed hemagglutination inhibition test, repeated pipetting operations are performed manually, and in the experimental process, the manual pipetting operation effect is poor in convenience and low in efficiency. The hemagglutination board can not reuse when the experiment to can not adjust the quantity of hemagglutination cup according to the demand is nimble, the practicality is relatively poor. Therefore, in view of the above-described situation, there is an urgent need to develop an imaging device for a hemagglutination inhibition test workstation to overcome the drawbacks in the current practical application.
Disclosure of Invention
The invention aims at: in order to solve the problem that the traditional hemagglutination inhibition test is manually repeated in pipetting operation, the manual pipetting operation effect in the experimental process is poor in convenience and low in efficiency. The utility model provides a blood coagulation inhibition imaging device for test workstation, in the time of the test blood coagulation board can not reuse to can not adjust the quantity of blood coagulation cup in a flexible way as required, the practicality subalternation problem.
In order to achieve the above purpose, the technical scheme of the invention is as follows: an imaging device for a hemagglutination inhibition test workstation comprises a mounting frame, a pipetting device, a combined hemagglutination plate and a swinging device; the swing equipment is arranged at the top of the mounting frame, transverse plates are arranged on two sides of the mounting frame, a half gear ring is fixedly arranged in the middle of the transverse plates, the pipetting equipment is arranged between the half gear rings on two sides, a mounting plate is arranged in the middle of the mounting frame, and the combined hemagglutination plate is arranged on the mounting plate; an imaging plate is arranged at the bottom of the mounting plate, and a plurality of groups of imaging devices are arranged on the imaging plate; the pipetting device comprises a transverse frame, wherein vertical plates are arranged on two sides of the transverse frame, a moving motor is arranged on each vertical plate, a screw rod is driven by the moving motor to rotate and arranged between the vertical plates, a moving block is arranged on the transverse frame in a sliding manner, a track is fixedly arranged between the moving blocks on two sides, and walking devices are arranged on the tracks; the bottom of the transverse frame is connected with the mounting plate through a connecting column; the combined blood coagulation plate comprises a blood coagulation cup and a mounting base, wherein the mounting base comprises a plurality of groups of fixed transverse plates, a plurality of groups of extrusion plates are movably mounted on the fixed transverse plates, and a plurality of groups of locking grooves are formed between the fixed transverse plates and the extrusion plates in a staggered manner.
As still further aspects of the invention: the bottom of the transverse frame is fixedly provided with a swing motor, an output shaft of the swing motor is connected with a swing gear, and the swing gear is meshed with the half gear ring.
As still further aspects of the invention: the transverse frame is provided with a sliding groove, a screw hole matched with the screw rod is formed in the moving block, and a sliding block matched with the sliding groove is arranged at the bottom of the moving block.
As still further aspects of the invention: the walking equipment comprises a walking frame moving along the track, convex plates are arranged on two sides of the walking frame, an air cylinder is arranged at the bottom of the convex plates, an output shaft of the air cylinder is fixedly connected with a lifting plate, and a plurality of groups of injectors are movably arranged on the lifting plate; the piston is movably arranged in the injector, a connecting pipe is arranged at the top of the injector, and the top of the connecting pipe is communicated with the injection box.
As still further aspects of the invention: the top of the piston is provided with an adjusting cap, and the top of the injector is fixedly provided with a magnetic attraction block matched with the adjusting cap.
As still further aspects of the invention: the inner side of the walking frame is rotatably provided with a plurality of groups of rollers, and the outer side of the walking frame is provided with a walking motor for driving the rollers to rotate.
As still further aspects of the invention: the inside rotation of hemagglutination cup is provided with turns over the board, the top of hemagglutination cup still is provided with the boss, the boss through first spring with turn over the board connection.
As still further aspects of the invention: the inner wall of the locking groove is provided with a groove, a second spring is arranged in the groove, the top of the second spring is provided with a ball, and the bottom of the blood coagulation cup is provided with a groove matched with the ball.
As still further aspects of the invention: the fixed transverse plate is provided with a mounting groove, and the extruding plate is movably mounted in the mounting groove; the extrusion plate comprises a fixing plate in the middle, a plurality of groups of extrusion blocks are movably mounted on two sides of the fixing plate, and the extrusion blocks are connected with the fixing plate through elastic columns.
As still further aspects of the invention: the swinging equipment comprises a driving gear and a fixed gear ring, a plurality of groups of planetary gears are movably arranged between the driving gear and the fixed gear ring, and a swinging seat is fixedly arranged at the top of each planetary gear.
The invention provides an imaging device for a hemagglutination inhibition test workstation through improvement, and compared with the prior art, the imaging device has the following beneficial effects:
1. according to the invention, the pipetting operations can be carried out from two sides simultaneously through the walking equipment at two sides, and a plurality of groups of blood coagulation cups can be pipetted at one time in the experimental process, so that the pipetting efficiency is greatly improved. The walking device and the combined blood coagulation plate can be swung under the action of the half gear ring and the swing gear, and the blood coagulation test can be imaged from multiple angles. Under the action of the moving motor and the moving block, the rail and the traveling equipment can be driven to integrally move transversely, so that the pipetting efficiency is further improved, and the time cost and the labor cost of the imaging device for the hemagglutination inhibition test workstation are greatly reduced.
2. According to the invention, the number of the blood coagulation cups can be flexibly adjusted according to the needs through the matching of the blood coagulation cups and the mounting base, and the mounting base is convenient to detach and reusable, so that the test cost is further reduced. Can double-clamp the blood coagulation cup under the action of the ball, the groove and the extrusion block, and can improve the stability when combining the swing of the blood coagulation plate. And the design of the swinging equipment avoids the coagulation and hemolysis phenomena of the blood sample before the test, and the design greatly improves the safety and the practicability of the imaging device for the hemagglutination inhibition test workstation.
Drawings
The invention is further explained below with reference to the drawings and examples:
FIG. 1 is a front view of the structure of the present invention;
FIG. 2 is a side view of the mounting bracket of the present invention;
FIG. 3 is an enlarged view of the structure of FIG. 2A in accordance with the present invention;
FIG. 4 is a side view of a pipetting device of the invention;
FIG. 5 is a schematic view of the walking device of the present invention;
FIG. 6 is an enlarged view of the structure of the present invention at B in FIG. 5;
FIG. 7 is a schematic diagram of the explosive structure of the combined platelets of the present invention;
FIG. 8 is an enlarged view of the structure of FIG. 7C in accordance with the present invention;
FIG. 9 is a cross-sectional view of the mounting base of the present invention;
fig. 10 is a schematic view showing a partial structure of the pressing plate in the present invention.
Reference numerals illustrate:
1. a mounting frame; 101. a cross plate; 102. a half gear ring; 103. a mounting plate; 104. an imaging plate; 105. an image forming apparatus; 106. a connecting column; 2. a pipetting device; 201. a cross frame; 202. a riser; 203. a moving motor; 204. a moving block; 205. a screw; 206. a chute; 207. a slide block; 208. a swing motor; 209. a swing gear; 210. a track; 211. a walking device; 212. a walking frame; 213. a roller; 214. a walking motor; 215. a convex plate; 216. a cylinder; 217. a lifting plate; 218. a syringe; 219. a piston; 220. an adjustment cap; 221. a magnetic suction block; 222. a connecting pipe; 223. an injection box; 3. combining the blood coagulation plates; 301. a blood coagulation cup; 302. a mounting base; 303. turning plate; 304. a boss; 305. a first spring; 306. a groove; 307. fixing the transverse plate; 308. a locking groove; 309. slotting; 310. a second spring; 311. a ball; 312. a mounting groove; 313. an extrusion plate; 314. a fixing plate; 315. extruding a block; 316. an elastic column; 4. a rocking device; 401. a drive gear; 402. a planetary gear; 403. fixing the gear ring; 404. and a swinging seat.
Detailed Description
The technical solutions of the present invention will be clearly and completely described below with reference to fig. 1 to 10, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The invention provides an imaging device for a hemagglutination inhibition test workstation by improvement, which is shown in fig. 1-10, and comprises a mounting frame 1, a pipetting device 2, a combined hemagglutination plate 3 and a swinging device 4; the swinging equipment 4 is arranged at the top of the mounting frame 1, the transverse plates 101 are arranged at the two sides of the mounting frame 1, the half gear rings 102 are fixedly arranged in the middle of the transverse plates 101, the pipetting equipment 2 is arranged between the half gear rings 102 at the two sides, the mounting plate 103 is arranged in the middle of the mounting frame 1, and the combined blood coagulation plate 3 is arranged on the mounting plate 103; the bottom of the mounting plate 103 is provided with an imaging plate 104, and a plurality of groups of imaging devices 105 are mounted on the imaging plate 104; the pipetting device 2 comprises a transverse frame 201, wherein vertical plates 202 are arranged on two sides of the transverse frame 201, a moving motor 203 is arranged on each vertical plate 202, a screw 205 driven by the moving motor 203 is rotatably arranged between the vertical plates 202, a moving block 204 is slidably arranged on the transverse frame 201, a track 210 is fixedly arranged between the moving blocks 204 on two sides, the bottom of the transverse frame 201 is connected with a mounting plate 103 through a connecting column 106, and a travelling device 211 is arranged on the track 210; the combined blood coagulation plate 3 comprises a blood coagulation cup 301 and a mounting base 302, wherein the mounting base 302 comprises a plurality of groups of fixed transverse plates 307, the fixed transverse plates 307 are movably provided with a plurality of groups of extrusion plates 313, and a plurality of groups of locking grooves 308 are formed between the fixed transverse plates 307 and the extrusion plates 313 in a staggered manner.
In this embodiment: the imaging device is mainly divided into four parts: a mounting frame 1, a pipetting device 2, a combined hemagglutination plate 3 and a swinging device 4. In use, the device is first placed in a vessel and then the vessel is placed on the rocking base 404. The driving gear 401 is started to enable the blood sample to rotate through the swinging device 4, so that the blood sample is prevented from coagulation and hemolysis in advance. When the combined blood coagulation plate 3 needs to be mounted, the blood coagulation cup 301 is pressed downward so that the bottom thereof is mounted on the mounting base 302. At this time, the balls 311 are locked into the grooves 306, and the pressing blocks 315 on both sides press both sides of the blood coagulation cup 301. And the number of installed squeeze plates 313 can be adaptively adjusted according to the number of desired blood coagulation cups 301. The blood sample is then injected into the injection cassette 223 on the walking device 211, turning on the walking motor 214. The running motor 214 drives the roller 213 to run to a preset position along the rail 210, and then the cylinder 216 is turned on. The cylinder 216 moves the syringe 218 downward and the syringe 218 presses the flap 303, at which point the flap 303 opens and pipetting through the syringe 218. When the syringe 218 leaves, the flap 303 is automatically reset under the action of the first spring 305. When the injector 218 needs to move to two sides, the moving motor 203 is started, and the moving motor 203 drives the screw 205 to rotate. At this time, the moving block 204 drives the track 210 and the traveling device 211 to move horizontally, so that the combined blood coagulation plates 3 located at both sides of the track 210 are pipetted. When blood needs to be analyzed and imaged from multiple angles through the imaging device 105, the swing motor 208 is started, and at the moment, the swing motor 208 drives the transverse frame 201 and the track 210 to deflect integrally by a small extent through the swing gear 209 and the half gear ring 102, so that the mounting plate 103 and the combined blood coagulation plate 3 are driven to deflect also by a small extent.
Referring to fig. 2-4, a swing motor 208 is fixedly arranged at the bottom of the transverse frame 201, an output shaft of the swing motor 208 is connected with a swing gear 209, and the swing gear 209 is meshed with the half gear ring 102.
In this embodiment: in order to analytically image blood from multiple angles by the imaging device 105, the bottom of the cross frame 201 is connected to the mounting plate 103 by the connecting posts 106. The swing motor 208 drives the transverse frame 201 and the track 210 to deflect integrally by a small extent through the swing gear 209 and the half gear ring 102, so that the mounting plate 103 and the combined blood coagulation plate 3 are driven to deflect also by a small extent.
Referring to fig. 2-3, a chute 206 is formed on a cross frame 201, a screw hole matched with a screw 205 is formed in a moving block 204, and a sliding block 207 matched with the chute 206 is arranged at the bottom of the moving block 204.
In this embodiment: in order to drive the rail 210 and the traveling device 211 to move horizontally, so that the combined blood coagulation plates 3 located at both sides of the rail 210 are pipetted, the moving block 204 is arranged on the transverse frame 201 in a sliding manner by driving the rail 210. In order to improve stability during sliding, a chute 206 is formed in the cross frame 201, and the moving block 204 is slidably disposed on the chute 206 through a slider 207 at the bottom.
Referring to fig. 4-5, the walking device 211 comprises a walking frame 212 moving along a track 210, wherein convex plates 215 are arranged on two sides of the walking frame 212, an air cylinder 216 is arranged at the bottom of the convex plates 215, an output shaft of the air cylinder 216 is fixedly connected with a lifting plate 217, and a plurality of groups of injectors 218 are movably arranged on the lifting plate 217; a piston 219 is movably arranged in the syringe 218, a connecting pipe 222 is arranged at the top of the syringe 218, and the top of the connecting pipe 222 is communicated with an injection box 223.
In this embodiment: in order to perform pipetting with the blood coagulation cup 301, air cylinders 216 are attached to both sides of the traveling frame 212. In order to uniformly charge the syringe 218, an injection case 223 is provided at the top of the syringe 218 and communicates with it through a connection pipe 222.
Referring to fig. 4 to 5, an adjusting cap 220 is provided at the top of the piston 219, and a magnetic block 221 engaged with the adjusting cap 220 is fixedly provided at the top of the syringe 218.
In this embodiment: in order to control the pipetting process, an adjusting cap 220 is provided on top of the piston 219. The adjusting cap 220 has magnetism, when micro current is input into the magnetic attraction block 221 under the control of the controller, the magnetic attraction block 221 also has magnetism, when opposite attraction is carried out, the adjusting cap 220 is attached to the magnetic attraction block 221, and the piston 219 locks the injector 218. When the direction of the micro current is changed, the magnetic attraction block 221 has opposite magnetism, the adjusting cap 220 is upwards away from the magnetic attraction block 221 when the like poles repel, the piston 219 releases the locking of the syringe 218, and the liquid flows out of the syringe 218.
Referring to fig. 4 to 5, a plurality of sets of rollers 213 are rotatably provided on the inner side of the traveling frame 212, and a traveling motor 214 for driving the rollers 213 to rotate is provided on the outer side of the traveling frame 212.
In this embodiment: in order to drive the carriage 212 to move along the rail 210, a carriage motor 214 for driving the rotation of the roller wheel 213 is provided on the outer side of the carriage 212.
Referring to fig. 7-8, a turning plate 303 is rotatably disposed in the blood coagulation cup 301, a boss 304 is further disposed on the top of the blood coagulation cup 301, and the boss 304 is connected with the turning plate 303 through a first spring 305.
In this embodiment: during the blood coagulation test, in order to prevent contamination of blood by foreign substances and other impurities, a flipping structure is rotatably provided inside the blood coagulation cup 301. Under the driving of the cylinder 216, the injector 218 moves downward and presses the flap 303, and at this time, the flap 303 opens and pipetting is performed through the injector 218. When the syringe 218 leaves, the flap 303 is automatically reset under the action of the first spring 305.
Referring to fig. 7-9, a slot 309 is formed in the inner wall of the locking slot 308, a second spring 310 is installed in the slot 309, a ball 311 is arranged at the top of the second spring 310, and a groove 306 matched with the ball 311 is formed at the bottom of the blood coagulation cup 301.
In this embodiment: to improve the stability of the blood coagulation cup 301 and lock the blood coagulation cup 301, it is prevented from falling off when it is swung. So the ball 311 is movably provided on the inner wall of the locking groove 308, and the groove 306 is provided on the bottom of the blood coagulation cup 301 to be engaged with the ball 311.
Referring to fig. 9 to 10, the fixed transverse plate 307 is provided with a mounting groove 312, and the pressing plate 313 is movably mounted in the mounting groove 312; the extrusion plate 313 comprises a fixing plate 314 in the middle, a plurality of groups of extrusion blocks 315 are movably arranged on two sides of the fixing plate 314, and the extrusion blocks 315 are connected with the fixing plate 314 through elastic columns 316.
In this embodiment: in order to facilitate the disassembly and assembly of the pressing plate 313 and the mounting base 302, and thereby the number of the blood coagulation cups 301 is mounted according to the need, the pressing plate 313 is movably mounted in the mounting groove 312. In order to further improve the stability of the blood coagulation cup 301, a plurality of groups of pressing blocks 315 are movably mounted on two sides of the fixing plate 314, and the blood coagulation cup 301 is clamped from two sides through the cooperation of the elastic columns 316.
Referring to fig. 1-2, the swinging device 4 comprises a driving gear 401 and a fixed gear ring 403, a plurality of groups of planetary gears 402 are movably arranged between the driving gear 401 and the fixed gear ring 403, and a swinging seat 404 is fixedly arranged at the top of each planetary gear 402.
In this embodiment: the blood sample is prevented from coagulation and hemolysis before the test, so that the swinging device 4 is designed in the device. The planetary gear 402 can drive the blood sample to swing and rotate, and the planetary gear 402 rotates with the driving gear 401 while revolving, so that the swinging effect is further improved.
Example 1: in use, the device is first placed in a vessel and then the vessel is placed on the rocking base 404. The driving gear 401 is started to enable the blood sample to rotate through the swinging device 4, so that the blood sample is prevented from coagulation and hemolysis in advance. The blood sample is then injected into the injection cassette 223 on the walking device 211, turning on the walking motor 214. The running motor 214 drives the roller 213 to run to a preset position along the rail 210, and then the cylinder 216 is turned on. The cylinder 216 moves the syringe 218 downward and the syringe 218 presses the flap 303, at which point the flap 303 opens and pipetting through the syringe 218. When the syringe 218 leaves, the flap 303 is automatically reset under the action of the first spring 305. When the injector 218 needs to move to two sides, the moving motor 203 is started, and the moving motor 203 drives the screw 205 to rotate. At this time, the moving block 204 drives the track 210 and the traveling device 211 to move horizontally, so that the combined blood coagulation plates 3 located at both sides of the track 210 are pipetted. When the combined blood coagulation plate 3 needs to be mounted, the blood coagulation cup 301 is pressed downward so that the bottom thereof is mounted on the mounting base 302. At this time, the balls 311 are locked into the grooves 306, and the pressing blocks 315 on both sides press both sides of the blood coagulation cup 301. And the number of installed squeeze plates 313 can be adaptively adjusted according to the number of desired blood coagulation cups 301. When blood needs to be analyzed and imaged from multiple angles through the imaging device 105, the swing motor 208 is started, and at the moment, the swing motor 208 drives the transverse frame 201 and the track 210 to deflect integrally by a small extent through the swing gear 209 and the half gear ring 102, so that the mounting plate 103 and the combined blood coagulation plate 3 are driven to deflect also by a small extent. Example 2: according to the invention, the two sides of the plurality of groups of the blood coagulation cups 301 can be simultaneously subjected to pipetting operation through the walking equipment 211 at the two sides, and the pipetting efficiency is greatly improved in the experimental process. The running gear 211 and the combined blood coagulation plate 3 can be swung under the action of the ring half 102 and the swing gear 209, which makes it possible to image the blood coagulation test from a plurality of angles. Under the action of the moving motor 203 and the moving block 204, the rail 210 and the traveling device 211 can be driven to integrally move transversely, so that the pipetting efficiency is further improved, and the time cost and the labor cost of the imaging device for the blood coagulation inhibition test workstation are also greatly reduced. According to the invention, the number of the blood coagulation cups 301 can be flexibly adjusted according to the needs by matching the blood coagulation cups 301 with the mounting base 302, and the mounting base 302 is convenient to detach and reusable, so that the test cost is further reduced. The double clamping of the blood coagulation cup 301 can be performed under the action of the ball 311 and the groove 306, and the pressing block 315, and the stability can be improved when the combined blood coagulation plate 3 swings. And the design of the swinging device 4 avoids the coagulation and hemolysis phenomena of the blood sample before the test, and greatly improves the safety and the practicability of the imaging device for the blood coagulation inhibition test workstation.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (9)
1. Imaging device for hemagglutination inhibition test workstation, including mounting bracket (1), pipetting device (2), combination hemagglutination board (3) and swing equipment (4), its characterized in that: the swing device (4) is arranged at the top of the mounting frame (1), transverse plates (101) are arranged on two sides of the mounting frame (1), a half gear ring (102) is fixedly arranged in the middle of each transverse plate (101), the pipetting device (2) is arranged between the half gear rings (102) on two sides, a mounting plate (103) is arranged in the middle of the mounting frame (1), and the combined hemagglutination plate (3) is arranged on the mounting plate (103); an imaging plate (104) is arranged at the bottom of the mounting plate (103), and a plurality of groups of imaging devices (105) are arranged on the imaging plate (104);
the pipetting device (2) comprises a transverse frame (201), wherein vertical plates (202) are arranged on two sides of the transverse frame (201), a moving motor (203) is installed on each vertical plate (202), a driving screw (205) of each moving motor (203) is rotatably arranged between the vertical plates (202), a moving block (204) is slidably arranged on the transverse frame (201), a track (210) is fixedly arranged between the moving blocks (204) on two sides of the transverse frame, the bottom of the transverse frame (201) is connected with the mounting plate (103) through a connecting column (106), and walking equipment (211) is installed on the track (210); the walking equipment (211) comprises a walking frame (212) which moves along the track (210), convex plates (215) are arranged on two sides of the walking frame (212), an air cylinder (216) is arranged at the bottom of each convex plate (215), an output shaft of each air cylinder (216) is fixedly connected with a lifting plate (217), and a plurality of groups of injectors (218) are movably arranged on each lifting plate (217); a piston (219) is movably arranged in the injector (218), a connecting pipe (222) is arranged at the top of the injector (218), and the top of the connecting pipe (222) is communicated with an injection box (223);
the combined blood coagulation plate (3) comprises a blood coagulation cup (301) and a mounting base (302), the mounting base (302) comprises a plurality of groups of fixed transverse plates (307), the fixed transverse plates (307) are movably provided with a plurality of groups of extrusion plates (313), and a plurality of groups of locking grooves (308) are formed between the fixed transverse plates (307) and the extrusion plates (313) in a staggered mode.
2. An imaging device for a hemagglutination inhibition assay workstation according to claim 1, wherein: the bottom of the transverse frame (201) is fixedly provided with a swing motor (208), an output shaft of the swing motor (208) is connected with a swing gear (209), and the swing gear (209) is meshed with the half gear ring (102).
3. An imaging device for a hemagglutination inhibition assay workstation according to claim 1, wherein: a sliding groove (206) is formed in the transverse frame (201), a screw hole matched with the screw rod (205) is formed in the moving block (204), and a sliding block (207) matched with the sliding groove (206) is arranged at the bottom of the moving block (204).
4. An imaging device for a hemagglutination inhibition assay workstation according to claim 1, wherein: an adjusting cap (220) is arranged at the top of the piston (219), and a magnetic attraction block (221) matched with the adjusting cap (220) is fixedly arranged at the top of the injector (218).
5. An imaging device for a hemagglutination inhibition assay workstation according to claim 1, wherein: the inner side of the walking frame (212) is rotatably provided with a plurality of groups of rollers (213), and the outer side of the walking frame (212) is provided with a walking motor (214) for driving the rollers (213) to rotate.
6. An imaging device for a hemagglutination inhibition assay workstation according to claim 1, wherein: the inside rotation of hemagglutination cup (301) is provided with turns over board (303), the top of hemagglutination cup (301) still is provided with boss (304), boss (304) through first spring (305) with turn over board (303) and be connected.
7. An imaging device for a hemagglutination inhibition assay workstation according to claim 1, wherein: the inner wall of the locking groove (308) is provided with a groove (309), a second spring (310) is arranged in the groove (309), the top of the second spring (310) is provided with a ball (311), and the bottom of the blood coagulation cup (301) is provided with a groove (306) matched with the ball (311).
8. An imaging device for a hemagglutination inhibition assay workstation according to claim 1, wherein: the fixed transverse plate (307) is provided with a mounting groove (312), and the extrusion plate (313) is movably mounted in the mounting groove (312); the extrusion plate (313) comprises a fixing plate (314) at the middle part, a plurality of groups of extrusion blocks (315) are movably mounted on two sides of the fixing plate (314), and the extrusion blocks (315) are connected with the fixing plate (314) through elastic columns (316).
9. An imaging device for a hemagglutination inhibition assay workstation according to claim 1, wherein: the swinging equipment (4) comprises a driving gear (401) and a fixed gear ring (403), a plurality of groups of planetary gears (402) are movably arranged between the driving gear (401) and the fixed gear ring (403), and a swinging seat (404) is fixedly arranged at the top of each planetary gear (402).
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| CN202311713345.7A CN117405675B (en) | 2023-12-14 | 2023-12-14 | Imaging device for hemagglutination inhibition test workstation |
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| CN202311713345.7A CN117405675B (en) | 2023-12-14 | 2023-12-14 | Imaging device for hemagglutination inhibition test workstation |
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| CN117405675A (en) | 2024-01-16 |
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