CN117398719B - Protein separation device for collecting urine and control system thereof - Google Patents
Protein separation device for collecting urine and control system thereof Download PDFInfo
- Publication number
- CN117398719B CN117398719B CN202311725730.3A CN202311725730A CN117398719B CN 117398719 B CN117398719 B CN 117398719B CN 202311725730 A CN202311725730 A CN 202311725730A CN 117398719 B CN117398719 B CN 117398719B
- Authority
- CN
- China
- Prior art keywords
- urine
- adsorption
- adjusting
- silica gel
- bin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000002700 urine Anatomy 0.000 title claims abstract description 148
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 57
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 57
- 238000000926 separation method Methods 0.000 title claims abstract description 32
- 238000001179 sorption measurement Methods 0.000 claims abstract description 198
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 109
- 239000000741 silica gel Substances 0.000 claims abstract description 105
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 105
- 239000007788 liquid Substances 0.000 claims abstract description 91
- 230000001105 regulatory effect Effects 0.000 claims abstract description 41
- 238000007789 sealing Methods 0.000 claims description 57
- 230000001276 controlling effect Effects 0.000 claims description 51
- 230000007246 mechanism Effects 0.000 claims description 39
- 238000004140 cleaning Methods 0.000 claims description 33
- 238000002360 preparation method Methods 0.000 claims description 28
- 238000003860 storage Methods 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 238000004891 communication Methods 0.000 claims description 11
- 238000007599 discharging Methods 0.000 claims description 10
- 238000011217 control strategy Methods 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 9
- 238000005187 foaming Methods 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 238000009434 installation Methods 0.000 claims description 4
- 238000011084 recovery Methods 0.000 abstract description 7
- 238000010586 diagram Methods 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 4
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 229960005356 urokinase Drugs 0.000 description 4
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 3
- 239000000956 alloy Substances 0.000 description 3
- 229910045601 alloy Inorganic materials 0.000 description 3
- 235000011114 ammonium hydroxide Nutrition 0.000 description 3
- 239000002518 antifoaming agent Substances 0.000 description 3
- 230000007797 corrosion Effects 0.000 description 3
- 238000005260 corrosion Methods 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 206010033647 Pancreatitis acute Diseases 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 201000003229 acute pancreatitis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/12—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/163—Pressure or speed conditioning
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/166—Fluid composition conditioning, e.g. gradient
- B01D15/168—Fluid composition conditioning, e.g. gradient pH gradient, chromatofocusing, i.e. separation according to the isoelectric point pI
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a protein separation device for collecting urine and a control system thereof, relates to the technical field of protein separation, and aims to solve the problems that an existing urine protein recovery adsorption device does not pretreat, mark and timely replace silica gel for the recovered urine. The protein separating device for collecting urine comprises a rack; the pre-adjusting device comprises a pre-adjusting bin, a sensor, a liquid outlet regulating valve and a raw liquid pump, wherein the pre-adjusting bin is arranged on the frame, the adsorption device comprises a guide pipe, an adsorption column, a pressure sensor and a regulating valve, the guide pipe is used for connecting the adsorption device and the pre-adjusting device, and the adsorption column is used for adsorbing protein in urine; the urine protein separation device also comprises a control system of the protein separation device, and the control system can control the protein separation device to automatically perform urine protein separation work, so that manual operation is reduced, and the protein separation adsorption efficiency in urine is improved.
Description
Technical Field
The invention relates to the technical field of protein separation, in particular to a protein separation device for collecting urine and a control system thereof.
Background
Naturally occurring natural products become valuable resources for treating human diseases by virtue of the unique advantages of low cost, good biological activity, no immunogen and the like, and protein products from human sources are one of the natural products.
The acquisition of the human protein mainly has two ways, namely urine and blood, and compared with blood, urine is easier to acquire, and through biotechnology development, various functional human urine protein products in human urine are successfully developed at present, and the human urine has very important roles in the medical fields of treating clinical critical diseases such as acute pancreatitis, shock, cerebral apoplexy and myocardial infarction, artificial assisted reproduction, burn shaping wound repair and the like.
For example, application publication No. CN116920457a, a protein separation device and a separation method thereof for collecting urine, including a separation device main body, an acceleration adsorption component is provided in the separation device main body, the acceleration adsorption component includes a main frame body and a partition rod body, the partition rod body is disposed in the main frame body and divides the main frame body into an upper region and a lower region, a heating net is disposed in the upper region, a plurality of silica gels are disposed in the separation device main body, two different silica gels adsorb urokinase with different molecular weights respectively, the separation device is stopped after stirring for a period of time, the silica gel suspended in urine can be divided into an upper layer and a lower layer, the upper layer is silica gel for adsorbing urokinase with small molecular weight, the lower layer is silica gel for adsorbing urokinase with large molecular weight, at this time, the heating net is electrified to heat the upper layer urine, and the activity of urokinase with small molecular weight at the upper layer is improved after heating.
When protein in urine is recovered, the existing urine protein recovery and adsorption device does not sample and judge the urine and regulate and mark the urine, so that the protein adsorption effect cannot be ensured, and when related medicines are manufactured, the production batch urine cannot be searched in a tracing way; when urine is adsorbed, the silica gel with charges in the adsorption column can not be replaced timely and effectively, manual replacement is often adopted, the recovery and adsorption of urine protein are affected, and the efficiency is low.
Therefore, the invention provides a protein separation device in collected urine and a control system thereof, which are used for solving the problems that the existing urine protein recovery adsorption device does not pretreat, mark and timely replace silica gel on the recovered urine.
Disclosure of Invention
The invention aims to provide a protein separation device for collecting urine and a control body thereof, so as to solve the problems that the existing urine protein recovery adsorption device provided in the background art lacks a urine pretreatment mark, silica gel in the adsorption device can not be effectively replaced at the time, and the protein production efficiency is affected.
In order to achieve the above purpose, the present invention provides the following technical solutions: a control system for a protein separation device in urine collection, applied to a protein separation device in urine collection, the protein separation device comprising:
A frame;
the pre-adjusting device comprises a pre-adjusting bin, a liquid inlet pipe, a sensor, a liquid outlet adjusting valve and a raw liquid pump, wherein the pre-adjusting bin is arranged on a frame, the liquid inlet pipe is arranged at the top of the pre-adjusting bin, the sensor is used for detecting urine in the pre-adjusting bin, the liquid outlet adjusting valve is used for outputting the urine in the pre-adjusting bin, the liquid outlet adjusting valve is provided with a first outlet and a second outlet, the first outlet is used for discharging the urine in the pre-adjusting bin, the second outlet is used for being connected with the raw liquid pump, and the raw liquid pump is used for pressurizing and conveying the urine;
the pre-adjusting device further comprises an adjusting assembly and a cleaning assembly, wherein the adjusting assembly is used for adjusting the pH value and the foaming amount of urine in the pre-adjusting bin, and the cleaning assembly is used for cleaning the pre-adjusting bin by water injection;
the adsorption device comprises a guide pipe, an adsorption column, a pressure sensor and a regulating valve, wherein the guide pipe is used for connecting the adsorption device with the pre-adjusting device, the adsorption column is used for adsorbing protein in urine, the pressure sensor is used for detecting the urine pressure in the adsorption device, and the regulating valve is used for regulating the flow rate of the urine in the adsorption device;
the control system comprises a pre-adjusting module and an adsorption module, wherein the pre-adjusting module is used for controlling the pre-adjusting device to pre-adjust input urine, the adsorption module is used for controlling the adsorption device to adsorb the pre-adjusted urine, the pre-adjusting module comprises a detection unit, an adjusting unit, a cleaning unit and a marking unit, and the detection unit acquires the pH value, the temperature and the conductivity of the urine in a pre-adjusting bin through a sensor and outputs a pH value signal, a temperature signal and a conductivity signal;
The regulating unit comprises a regulating strategy, the regulating strategy comprises the steps of acquiring a pH value signal, judging a pH value interval, outputting a liquid discharge instruction if the pH value is larger than a first threshold value or smaller than a second threshold value, opening a first outlet by the liquid outlet regulating valve based on the liquid discharge instruction, discharging urine in the pre-regulating bin and outputting a liquid discharge completion signal; if the pH value is greater than or equal to a second threshold value and less than or equal to a first threshold value, outputting an adjusting instruction, wherein the adjusting assembly adjusts the pH value of urine in the pre-adjusting bin based on the adjusting instruction, and if the pH value of the urine in the pre-adjusting bin is in a proper interval, outputting an adjusting completion signal and a liquid outlet instruction, wherein the liquid outlet adjusting valve opens a second outlet based on the liquid outlet instruction, outputs the urine to a raw liquid pump, and outputs a liquid outlet completion signal;
the cleaning unit is used for acquiring a liquid discharge completion signal or a liquid discharge completion signal and outputting a cleaning instruction, the cleaning assembly is used for carrying out water injection cleaning on the pre-adjustment bin based on the cleaning instruction and outputting the cleaning completion signal and the liquid discharge instruction, and the liquid discharge regulating valve is used for opening the first outlet based on the liquid discharge instruction and discharging liquid in the pre-adjustment bin;
when the marking unit monitors and acquires the adjustment completion signal, the pH value signal, the temperature signal and the conductivity signal which are output by the detection unit at the moment are acquired, the urine after adjustment is marked, and the marking signal is output.
Preferably, the adsorption column comprises an electromagnetic valve, a sealing shell, a silica gel column, a timer and an electromagnetic sleeve, wherein the electromagnetic valve is used for opening or closing a channel of the adsorption column so as to control urine to enter the adsorption column or prevent the urine from entering the adsorption column, an electromagnetic opening and closing device is arranged on one side of the bottom of the sealing shell, an electromagnetic guide rail is arranged on the rack, the electromagnetic opening and closing device is arranged on the electromagnetic guide rail, an electromagnet is arranged on the outer side of the sealing shell, a labyrinth sealing structure for sealing a joint of the sealing shell is arranged on the side edge of the sealing shell, the electromagnetic opening and closing device and the electromagnet are used for opening or closing the sealing shell, and the electromagnetic sleeve and the silica gel column are detachably connected.
Preferably, the adsorption device further comprises: the device comprises a preparation bin and a storage bin, wherein the preparation bin is used for storing unused silica gel columns, and the storage bin is used for storing silica gel columns reaching adsorption time.
Preferably, the adsorption device further comprises a clamping and replacing assembly, the clamping and replacing assembly comprises a movable vehicle body and a clamping and replacing actuator, the movable vehicle body is connected with the rack and used for moving along the rack, a sliding rail is arranged at the bottom of the movable vehicle body, an electric cylinder is arranged on the sliding rail, the clamping and replacing actuator is arranged on the sliding rail and used for driving the clamping and replacing actuator to move along the sliding rail, a hydraulic cylinder is arranged on the clamping and replacing actuator, and the hydraulic cylinder is used for controlling the clamping and replacing actuator to move in a telescopic mode, and the clamping and replacing actuator is used for clamping a silica gel column in the preparation bin and replacing and installing the silica gel column in the adsorption column.
Preferably, the mobile vehicle body is provided with a positioner, the positioner is used for positioning the position of the mobile vehicle body, the clamping actuator comprises a rotating disc and a clamping mechanism, the rotating disc is used for rotating the clamping mechanism to align with a silica gel column in the preparation bin or a silica gel column in the adsorption column, and the clamping mechanism is used for clamping the silica gel column.
Preferably, the adsorption module comprises a pressure control unit, the pressure control unit obtains the urine pressure in the adsorption device through a pressure sensor, if the pressure is greater than a preset upper limit pressure, a high-pressure signal is output, the regulating valve is controlled to reduce the urine flow rate in the adsorption device, if the pressure is lower than a preset lower limit pressure, a low-pressure signal is output, and the regulating valve is controlled to improve the urine flow rate in the adsorption device.
Preferably, the adsorption module further comprises an adsorption column control unit, the adsorption column control unit comprises an adsorption column control strategy, the adsorption column control strategy comprises that the working time of the silica gel column is obtained through a timer, if the working time of the silica gel column is larger than the preset time, a replacement signal is output, an electromagnetic valve of the adsorption column is controlled to be closed, urine is prevented from entering the adsorption column, an electromagnetic opening-closing device and an electromagnet are controlled to be opened, the joint of the sealing shell is separated through a labyrinth sealing structure, the sealing shell is controlled to be opened, the internal silica gel column is exposed, and an adsorption column position signal is output.
Preferably, the adsorption module further comprises a replacement unit, the replacement unit comprises a replacement strategy, the replacement strategy comprises that a coordinate system is established along the frame, the position of the preparation bin is taken as an origin of the coordinate system, the coordinates of the mobile vehicle body are obtained through the positioner, the mobile vehicle body is controlled to move to the preparation bin along the frame based on the coordinates of the mobile vehicle body and the coordinates of the preparation bin, the unused silica gel column in the preparation bin is clamped through the control of the rotating disc and the clamping mechanism, and a clamping completion signal is output; determining the coordinates of an adsorption column in a coordinate system based on the coordinates of the adsorption column and the current coordinates of a movable vehicle body, controlling the movable vehicle body to move along a rack to the coordinates of the adsorption column, controlling a rotating disc to descend through a hydraulic cylinder, driving a clamping actuator to move on a sliding rail through the electric cylinder, aligning a clamping mechanism to a silica gel column, clamping the silica gel column reaching adsorption time in the adsorption column through the clamping mechanism, controlling the electromagnetic sleeve to shrink so that the silica gel column is separated from the electromagnetic sleeve, controlling the clamping mechanism to move downwards so that the silica gel column is separated from an upper guide pipe, driving the clamping actuator to move towards the center of the sliding rail through the electric cylinder, driving the silica gel column reaching adsorption time to separate from the adsorption column through the electric cylinder, controlling the rotating disc to rotate, aligning the unused silica gel column to replace the adsorption column, controlling the electric cylinder to drive the clamping actuator and installing the unused silica gel column into the adsorption column through the clamping mechanism, controlling the clamping mechanism to move upwards so that the unused silica gel column is connected with the upper guide pipe and controlling the electromagnetic sleeve to stretch and fix the unused silica gel column, and after the unused silica gel column is fixed, loosening the clamping mechanism and driving the clamping actuator through the electric cylinder to drive the clamping actuator to lift to control the rotating disc to return to the rotating disc, and outputting a signal to the lifting position; the method comprises the steps of obtaining position coordinates of a storage bin, controlling the mobile vehicle body to move to the storage bin along a rack based on the current coordinates of the mobile vehicle body, placing a silica gel column reaching adsorption time in the storage bin through controlling a rotating disc and a clamping mechanism, and outputting a replacement completion signal.
Preferably, the adsorption column control strategy further comprises the steps of acquiring an in-place signal, controlling the electromagnetic opening and closing device to be closed, sealing the joint of the sealing shell through the labyrinth sealing structure, controlling the electromagnet to attract, completing the sealing installation of the silica gel column in the adsorption column, controlling the timer to reset the timing and controlling the electromagnetic valve of the adsorption column to be opened, conducting the adsorption column to receive urine in the adsorption device, and outputting a normal working signal.
Preferably, the control system further comprises a network communication module, wherein the network communication module is used for transmitting control system signals to the upper computer and receiving control instructions sent by the upper computer.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the collected urine is preprocessed, so that the recovery quality of specific proteins in the urine is improved, the recovered urine is marked, the recovered urine of a corresponding production batch can be searched in a traceable way during the production of the human urine protein medicines, the quality of the human urine protein medicines is ensured, and the human urine protein medicines in the same batch are uniformly monitored;
according to the invention, by designing the adsorption column structure and using the labyrinth seal structure, the electromagnetic opening and closing device and the electromagnet, the perfect sealing effect of the adsorption column is ensured, the urine overflow phenomenon is avoided, the internal silica gel adsorption effect is improved, and meanwhile, the unused silica gel column and the silica gel column reaching the adsorption time can be clamped simultaneously by using the rotating disc and the clamping actuator on the mobile vehicle body, so that the silica gel replacement efficiency is improved, and the urine protein recovery adsorption efficiency is improved;
The invention provides a control system of a protein separation device, which is used for automatically controlling pretreatment of urine in a pre-adjustment bin, cleaning the pre-adjustment bin with clear water in batches, avoiding the mutual influence of urine in different batches, simultaneously, controlling an adsorption column in an adsorption device to automatically time and replace silica gel, controlling the valve of the adsorption column to open and close, automatically controlling the adsorption operation, reducing manual operation and improving the production efficiency;
the control system of the protein separation device comprises a network communication module, provides real-time data transmission, is convenient for an upper computer to monitor the production process, and further adjusts the production process by issuing a control instruction.
Drawings
FIG. 1 is a schematic overall structure of a first embodiment of the present invention;
FIG. 2 is a schematic diagram of a preconditioning apparatus according to the present invention;
FIG. 3 is a schematic diagram of the liquid inlet part of the pre-adjusting bin of the invention;
FIG. 4 is a schematic diagram of an adsorption apparatus according to a first embodiment of the present invention;
FIG. 5 is a schematic diagram of the overall structure of a second embodiment of the present invention;
FIG. 6 is a schematic diagram of a second adsorption apparatus according to an embodiment of the present invention;
FIG. 7 is an enlarged schematic view of the invention at A in FIG. 6;
FIG. 8 is a schematic view of a second clamping and replacing assembly according to an embodiment of the present invention;
FIG. 9 is a schematic view of a slide rail, an electric cylinder and a hydraulic cylinder of a second clamping and replacing assembly according to an embodiment of the present invention;
FIG. 10 is a schematic diagram showing a disassembled structure of a second adsorption column according to the embodiment of the present invention;
FIG. 11 is a schematic diagram of a labyrinth seal in a second adsorption column according to an embodiment of the present invention;
FIG. 12 is a logic diagram of a pre-adjustment module of the control system of the present invention;
FIG. 13 is a logic diagram of an adsorption module of the control system of the present invention;
fig. 14 is a schematic diagram illustrating communication between a third device and an upper computer according to an embodiment of the present invention.
In the figure: 100. a frame; 101. a movable shaft; 200. a pre-adjusting device; 201. presetting a bin; 202. a sensor; 203. a liquid outlet regulating valve; 204. a raw liquid pump; 205. a first outlet; 206. a second outlet; 207. a liquid inlet pipe; 210. an adjusting assembly; 211. hydrochloric acid liquid mixing and feeding pipe; 212. ammonia water liquid mixing and feeding pipe; 213. a defoamer inlet pipe; 220. cleaning the assembly; 221. a water inlet pipe; 222. a water inlet pipe control valve; 300. an adsorption device; 301. a flow guiding pipe; 302. a pressure sensor; 303. a regulating valve; 310. an adsorption column; 311. an electromagnetic valve; 312. a sealed housing; 313. a silica gel column; 314. a timer; 315. a labyrinth seal structure; 316. an electromagnetic opening and closing device; 317. an electromagnet; 318. an electromagnetic guide rail; 319. an electromagnetic sleeve; 320. preparing a bin; 321. a storage bin; 330. clamping and replacing the assembly; 340. moving the vehicle body; 341. a positioner; 342. a slide rail; 343. an electric cylinder; 344. a hydraulic cylinder; 350. clamping an actuator; 351. a rotating disc; 352. and a clamping mechanism.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments.
Example 1
Referring to fig. 1-4 and fig. 12, one embodiment of the present invention is provided: a protein separation device for collecting urine and a control system thereof, wherein the protein separation device for collecting urine comprises:
the rack 100, the rack 100 is made of corrosion-resistant and rust-resistant materials, and the rack 100 can be correspondingly adjusted in structure so as to adapt to device installation;
the pre-adjusting device 200, the pre-adjusting device 200 comprises a pre-adjusting bin 201, a liquid inlet pipe 207, a sensor 202, a liquid outlet regulating valve 203 and a raw liquid pump 204, the pre-adjusting bin 201 is arranged on the frame 100, the pre-adjusting bin 201 can be arranged on one side or the top of the frame 100, the pre-adjusting bin 201 is made of corrosion-resistant and rust-resistant materials, such as titanium-based alloy or nickel-based alloy, the liquid inlet pipe 207 is arranged on the top of the pre-adjusting bin 201 and is used for conveying collected urine, the sensor 202 is used for detecting the urine in the pre-adjusting bin 201, the sensor 202 comprises a pH meter, a thermometer, a conductivity meter and the like and is used for measuring the urine state, the liquid outlet regulating valve 203 is used for outputting the urine in the pre-adjusting bin 201, the liquid outlet regulating valve 203 is provided with a first outlet 205 and a second outlet 206, the liquid outlet 205 is controlled by an electric signal, the first outlet 205 is used for discharging the urine in the pre-adjusting bin 201, the second outlet 206 is used for being connected with the raw liquid pump 204, the raw liquid pump 204 is used for pressurizing and conveying the urine, the raw liquid pump 204 can be controlled by the electric signal to control switch and pressurizing size, and the system is convenient to control;
The adsorption device 300, the adsorption device 300 includes honeycomb duct 301, adsorption column 310, pressure sensor 302 and governing valve 303, the honeycomb duct 301 is used for connecting adsorption device 300 and preset device 200, be provided with the machinery discharge valve such as steady voltage valve, relief valve on the honeycomb duct 301, avoid the intraductal pressure too big lead to honeycomb duct 301 to break, adsorption column 310 is arranged in adsorbing the protein in the urine, pressure sensor 302 is arranged in detecting the urine pressure in the adsorption device 300, governing valve 303 is arranged in adjusting the velocity of flow of urine in the adsorption device 300, governing valve 303 and above-mentioned raw materials pump 204, the corresponding adjustment of honeycomb duct 301 diameter, corresponding flow control formula is:
where Q is the flow, V is the flow velocity, D is the inside diameter of the flow conduit, and the flow of urine in the flow conduit 301 is controlled according to the above formula.
The pre-adjusting device 200 further comprises an adjusting assembly 210 and a cleaning assembly 220, the adjusting assembly 210 is used for adjusting the pH value and foaming amount of urine in the pre-adjusting bin 201, the adjusting assembly 210 is provided with a hydrochloric acid liquid adjusting inlet pipe 211, an ammonia water liquid adjusting inlet pipe 212 and a defoaming agent inlet pipe 213, each inlet pipe is correspondingly provided with a corresponding control inlet pipe electromagnetic valve, the corresponding inlet pipe electromagnetic valves can be controlled to be opened and closed by control signals sent out by the system so as to control the hydrochloric acid, the ammonia water and the defoaming agent to enter the pre-adjusting bin 201, the defoaming agent can be polyether modified silicone oil or other substances for inhibiting and eliminating urine foaming substances, the cleaning assembly 220 is used for injecting water to clean the pre-adjusting bin 201, the cleaning assembly 220 is provided with a water inlet pipe 221 and a water inlet pipe control valve 222, clear water is controlled to enter the pre-adjusting bin 201 by controlling the water inlet pipe control valve 222, and clear water is flushed to the pre-adjusting bin 201.
A control system of a protein separation device for collecting urine comprises a pre-adjusting module and an adsorption module, wherein the pre-adjusting module comprises a detection unit, an adjusting unit, a cleaning unit and a marking unit.
The detection unit acquires the pH value, the temperature and the conductivity of urine in the pre-adjustment bin 201 through the sensor 202, and outputs a pH value signal, a temperature signal and a conductivity signal, the adjustment unit acquires the pH value signal, judges a pH value interval through an internal adjustment strategy, and if the pH value is larger than a first threshold value or smaller than a second threshold value, namely pH is more than 7 or less than 6, a liquid discharge instruction is output, the liquid discharge adjusting valve 203 opens the first outlet 205 based on the liquid discharge instruction, discharges urine in the pre-adjustment bin 201 and outputs a liquid discharge completion signal; if the pH value is greater than or equal to the second threshold value and less than or equal to the first threshold value, that is, the pH value is greater than or equal to 6 and less than or equal to 7, an adjusting instruction is output, the adjusting assembly 210 adjusts the pH value of urine in the pre-adjusting bin 201 based on the adjusting instruction, if the pH value of urine in the pre-adjusting bin 201 is in a proper interval, the proper interval is 6.45 and less than or equal to pH and less than or equal to 6.55, an adjusting completion signal is output, the liquid outlet adjusting valve 203 is controlled to open the second outlet 206, urine is output to the raw liquid pump 204, and a liquid outlet completion signal is output.
The cleaning unit obtains a liquid discharge completion signal or a liquid discharge completion signal, outputs a cleaning instruction, the cleaning assembly 220 opens the water inlet pipe control valve 222 based on the cleaning instruction, injects clean water into the pre-adjustment bin 201, washes the pre-adjustment bin 201, closes the water inlet pipe control valve 222 after washing, outputs the cleaning completion signal and the liquid discharge instruction, and the liquid discharge regulating valve 203 discharges liquid in the pre-adjustment bin 201 based on the liquid discharge instruction.
When the marking unit obtains the adjustment completion signal, the pH value signal, the temperature signal and the conductivity signal which are output by the detection unit at the moment are obtained, the GPS position information and the time stamp of the urine recycling place are obtained, the batch of urine is marked, and the marking signal is output to mark the batch of urine.
The adsorption module comprises a pressure control unit, the pressure control unit obtains the urine pressure in the adsorption device 300 through a pressure sensor 302, if the pressure is greater than a preset upper limit pressure, a high-pressure signal is output, a regulating valve 303 is controlled to reduce the urine flow rate in the adsorption device 300, if the pressure is lower than a preset lower limit pressure, a low-pressure signal is output, the regulating valve 303 is controlled to improve the urine flow rate in the adsorption device 300, the upper and lower limit pressures are determined according to the actual bearing range of a guide pipe 301 in the actual production process, the guide pipe 301 is made of a corrosion-resistant material, and a PVC plastic pipe, a titanium-based alloy high-pressure pipe and the like can be selected.
Working principle: the pre-adjusting device 200 and the adsorption device 300 are arranged on the frame 100, the pre-adjusting device 200 is provided with a pre-adjusting bin 201, collected urine is introduced into the pre-adjusting bin 201 through a liquid inlet pipe 207, relevant urine parameters are obtained through a sensor 202, the quality of the urine is judged through an adjusting strategy in an adjusting unit of a control system, and whether the urine is further adjusted or not is determined; if the urine quality is not expected, controlling the liquid outlet regulating valve 203 to open the first outlet 205 to directly discharge liquid and output a liquid discharge completion signal, if the urine needs to be regulated further, controlling the regulating assembly 210 through the regulating unit to regulate the pH value of the urine and reduce the foaming amount of the urine, outputting the regulating completion signal after the regulation is completed and controlling the liquid outlet regulating valve 203 to open the second outlet 206 to convey the urine to the raw liquid pump 204, and outputting the liquid outlet completion signal; the cleaning unit controls the cleaning assembly 220 to inject clean water into the pre-adjustment bin 201 to flush the pre-adjustment bin 201 according to the liquid discharging completion signal or the liquid discharging completion signal, and controls the liquid discharging regulating valve 203 to discharge liquid in the pre-adjustment bin 201 after flushing is completed; the marking unit marks the batch of urine according to the adjustment completion signal, records urine parameter information, position information and time information, and is convenient for the follow-up tracing inquiry of human urine protein medicines; the absorption module controls the flow rate of urine in the absorption device 300 by arranging the mechanical exhaust valve, the pressure sensor 302 and the regulating valve 303, so that the pressure in the absorption device 300 is not excessive, and the normal operation of the urine protein absorption process is ensured.
Example 2
Referring to fig. 5-11, fig. 13, further modified on the basis of the first embodiment, the adsorption column 310 on the adsorption device 300 includes an electromagnetic valve 311, a sealing shell 312, a silica gel column 313, a timer 314 and an electromagnetic sleeve 319, the electromagnetic valve 311 is used for opening or closing a channel of the adsorption column 310 to control urine to enter the adsorption column 310 or prevent urine from entering the adsorption column 310, an electromagnetic opening and closing device 316 is arranged at one side of the bottom of the sealing shell 312, an electromagnetic guide rail 318 is arranged at a connection position of the electromagnetic opening and closing device 316 and the frame 100, the electromagnetic opening and closing device 316 moves on the electromagnetic guide rail 318 according to instructions, an electromagnet 317 is arranged at the outer side of the sealing shell 312, a labyrinth sealing structure 315 for sealing the connection position of the sealing shell 312 is arranged at the side of the sealing shell 312, the electromagnetic opening and closing device 316 and the electromagnet 317 are also replaced by corresponding opening and closing devices controlled by electric signals, the labyrinth sealing structure 315 is replaced by sealing structures such as a sealing ring, the sealing structure prevents urine from seeping out of the adsorption column 310 in the inside during operation, the adsorption column 310 is improved, the adsorption effect is controlled by the electromagnetic opening and closing device, the electromagnetic sleeve 319 can control the electromagnetic sleeve 313 and the sealing sleeve 313 can be connected by the electromagnetic sleeve 313.
The adsorption device 300 further comprises a preparation bin 320 and a storage bin 321, wherein the preparation bin 320 is used for storing unused silica gel column 313, the storage bin 321 is used for storing silica gel column 313 reaching adsorption time, silica gel with specific charges is arranged on the silica gel column 313, and the specific charges of the silica gel can be correspondingly adjusted according to proteins to be adsorbed.
The adsorption device 300 further comprises a clamping and replacing assembly 330, the clamping and replacing assembly 330 comprises a movable vehicle body 340 and a clamping actuator 350, the movable vehicle body 340 is movably connected with the frame 100, a sliding rail 342 is arranged at the bottom of the movable vehicle body 340 through a movable shaft 101 on the frame 100, a power device such as a cable and the like, the sliding rail 342 is provided with an electric cylinder 343, the clamping actuator 350 is arranged on the sliding rail 342, the clamping actuator 350 can be driven to move in a positioning mode on the sliding rail 342 through the electric cylinder 343, a hydraulic cylinder 344 is arranged on the clamping actuator 350, the hydraulic cylinder 344 is used for controlling the clamping actuator 350 to stretch and retract, and the clamping actuator 350 is used for clamping the silica gel column 313 in the preparation bin 320 and replacing and installing the silica gel column 313 in the adsorption column 310.
The movable car body 340 is provided with a positioner 341, the positioner 341 is used for positioning the position of the movable car body 340, the clamping actuator 350 comprises a rotating disc 351 and a clamping mechanism 352, the rotating disc 351 is used for rotating the clamping mechanism 352, the clamping mechanism 352 is used for clamping the silica gel column 313, the number of the clamping mechanisms 352 on the rotating disc 351 can be two or more, a plurality of silica gel columns 313 can be conveniently clamped at the same time, the rotating disc 351 is of an orientable rotating structure, the rotating angle can be conveniently controlled, and the clamping mechanism 352 is aligned with the silica gel columns 313.
The adsorption module further comprises an adsorption column control unit, the adsorption column control unit comprises an adsorption column control strategy, the adsorption column control strategy comprises that the working time of a silica gel column 313 is obtained through a timer 314, if the working time of the silica gel column 313 is larger than the preset time, a replacement signal is output, an electromagnetic valve 311 of the adsorption column 310 is controlled to be closed, urine is prevented from entering the adsorption column 310, an electromagnetic opener 316 and an electromagnet 317 are controlled to be opened, the joint of a sealing shell 312 is separated through a labyrinth sealing structure 315, the sealing shell 312 is controlled to be opened, the inside silica gel column 313 is exposed, a position signal of the adsorption column 310 is output, and the preset time of the silica gel column 313 is determined according to the diameter of the silica gel column 313, the type of silica gel and the flow rate of urine in the adsorption column 310 in the actual production process.
The adsorption module further comprises a replacement unit, the replacement unit comprises a replacement strategy, the replacement strategy comprises that a coordinate system is established along the rack 100, the position of the preparation bin 320 is taken as an origin of the coordinate system, the position of the movable car body 340 is obtained through the positioner 341, real-time coordinate monitoring of the movable car body 340 can be achieved through a mode of arranging a signal generator on the movable car body 340, the movable car body 340 is controlled to move to the preparation bin 320 along the rack 100 based on the position of the movable car body 340 and the coordinate of the preparation bin 320, for example, the movable car body 340 is controlled to move along one axis of the rack 100 through a cable car structure and a control cable, the unused silica gel column 313 in the preparation bin 320 is clamped through the rotating disc 351 of the clamping actuator 350, the plurality of clamping mechanisms 352 can clamp the plurality of silica gel columns 313 simultaneously, and at least one clamping mechanism 352 needs to be controlled to be reserved for subsequent replacement work.
After the replacement unit acquires the position signal of the adsorption column 310, determining the coordinates of the adsorption column 310 needing replacement in a coordinate system based on the position signal of the adsorption column 310, controlling the movable vehicle body 340 to move to the coordinate position of the adsorption column 310 along the frame 100 based on the coordinates of the adsorption column 310 and the current coordinates of the movable vehicle body 340, controlling the rotary disk 351 to be lowered down through the hydraulic cylinder 344, driving the clamping actuator 350 to move on the sliding rail 342 by the electric cylinder 343 in parallel with the central position area of the adsorption column 310, aligning the clamping mechanism 352 with the silica gel column 313, clamping the silica gel column 313 reaching adsorption time in the adsorption column 310 through the clamping mechanism 352, controlling the contraction of the electromagnetic sleeve 319 to enable the silica gel column 313 to be separated from the electromagnetic sleeve 319, controlling the clamping mechanism 352 to move downwards to enable the silica gel column 313 to be separated from the upper guide pipe 301, driving the clamping actuator 350 to move towards the center of the sliding rail 342 through the electric cylinder 343 to enable the silica gel column 313 reaching adsorption time to be separated from the adsorption column 310, controlling the rotary disk 351 to rotate, aligning the unused silica gel column 313 with the central position of the adsorption column 310, controlling the rotary disk 352 to drive the clamping actuator 350 to move, driving the clamping actuator 350 to enable the unused silica gel column 313 to move up through the clamping mechanism 352 to be arranged in the guide pipe 352, and returning the control cylinder 313 to the position of the unused guide pipe 313 to the original position by the control cylinder 313, and driving the clamping mechanism to be connected with the unused silica gel column 313 to the rotary disk; the position coordinates of the storage bin 321 are acquired, the moving vehicle body 340 is controlled to move to the storage bin 321 along the frame 100 based on the current coordinates of the moving vehicle body 340, the silica gel column 313 reaching the adsorption time is placed in the storage bin 321 by controlling the rotating disc 351 and the clamping mechanism 352, and a replacement completion signal is output.
After the replacement is completed, the position coordinates of the storage bin 321 are acquired, the mobile vehicle body 340 is controlled to move to the storage bin 321 along the frame 100 based on the current coordinates of the mobile vehicle body 340, the silica gel column 313 reaching the adsorption time is placed in the storage bin 321 through the control rotating disc 351 and the clamping mechanism 352, a replacement completion signal is output, and the mobile vehicle body 340 is controlled to move to the preparation bin 320 along the frame 100 to clamp the unused silica gel column 313 to wait for the next replacement based on the current coordinates of the mobile vehicle body 340 and the coordinates of the preparation bin 320.
The adsorption column control strategy further comprises the steps of acquiring an in-place signal, controlling the electromagnetic opening and closing device 316 to be closed, sealing the joint of the sealing shell 312 through the labyrinth sealing structure 315, controlling the electromagnet 317 to attract, completing the sealing installation of the silica gel column 313 in the adsorption column 310, controlling the timer 314 to reset the timing and controlling the electromagnetic valve 311 of the adsorption column 310 to be opened, conducting the adsorption column 310 to receive urine in the adsorption device 300, and outputting a normal working signal.
The adsorption columns 310 are installed on the frame 100, the number of the adsorption columns 310 can be multiple, the adsorption columns 310 can be adjusted and installed according to production, the adsorption columns 310 can be connected in series or in parallel by adjusting the silica gel charges of unused silica gel columns 313 in the preparation bin 320 to control the adsorption of the urine protein types by the adsorption columns 310, if a large number of adsorption is needed, a plurality of adsorption columns 310 can be connected in parallel, if a plurality of proteins are needed to be absorbed, different types of adsorption columns 310 can be connected in series, and the requirement of simultaneously obtaining the proteins in a plurality of urine is met.
Working principle: the structure of the adsorption column 310 is further improved, an electromagnetic valve 311, a sealing shell 312, a silica gel column 313 and a timer 314 are arranged, an electromagnet 317 and an electromagnetic opener 316 are arranged outside the sealing shell 312, the opening and the closing of the sealing shell 312 can be controlled through an electric signal, and the sealing shell 312 is sealed by adopting a labyrinth sealing structure 315, so that liquid in the sealing shell 312 is prevented from exuding; a preparation bin 320 and a storage bin 321 are arranged at two ends of the frame 100 and are respectively used for storing unused silica gel column 313 and silica gel column 313 reaching adsorption time; a movable body 340 is arranged on the frame 100, the movable body 340 can move along the frame 100, a clamping actuator 350 is arranged on the movable body 340 for clamping the silica gel column 313, and the movable body 340 is controlled to move based on the coordinates of the movable body 340 and the target coordinates by establishing a coordinate system; the adsorption column 310 controls the electromagnetic valve 311 to be closed based on the timer 314 to prevent urine from entering the adsorption column 310, simultaneously controls the electromagnetic opening and closing device 316 and the electromagnet 317 to open the sealing shell 312 to expose the silica gel column 313 in the adsorption column 310, and controls the clamping actuator 350 to clamp the unused silica gel column 313 from the preparation bin 320 and move to the position of the adsorption column 310 to replace the silica gel column 313 in the adsorption column 310, and after replacement, the moving vehicle 340 conveys the silica gel column 313 reaching the adsorption time to the storage bin 321; meanwhile, the timer 314 is reset to count time, the adsorption column 310 is controlled to be closed again through the electromagnetic switch 316 and the electromagnet 317, the electromagnetic valve 311 is opened to receive urine, and the next adsorption work is started.
The adsorption columns 310 can be connected in series or in parallel by controlling the silica gel charges on the unused silica gel column 313, if a large amount of adsorption is needed, a plurality of adsorption columns 310 can be connected in parallel, if a plurality of proteins are needed to be absorbed, different kinds of adsorption columns 310 can be connected in series, and the requirements for simultaneously acquiring the proteins in a plurality of urine can be met.
Example 3
Referring to fig. 14, further improved on the basis of the second embodiment, the control system further includes a network communication module, the protein separation device can transmit each signal to the upper computer through the network communication module, the upper computer can monitor the real-time process of the device through PID (proportion integration differentiation) diagrams, i.e. process simulation flow charts, etc., and can output control instructions to be transmitted to the device, so as to perform manual control on the device, such as emergency stop, etc.; the network communication module can realize data transmission by arranging WIFI signals, plugging telephone cards and the like on site.
In the embodiments provided in the present application, it should be understood that the disclosed apparatus and method may be implemented in other manners. The above-described apparatus embodiments are merely illustrative, for example, the division of the units is merely a logical function division, and there may be other manners of division in actual implementation, and for example, multiple units or components may be combined or integrated into another system, or some features may be omitted, or not performed. Alternatively, the coupling or direct coupling or communication connection shown or discussed with each other may be through some communication interface, device or unit indirect coupling or communication connection, which may be in electrical, mechanical or other form.
Finally, it should be noted that: the above examples are only specific embodiments of the present invention, and are not intended to limit the scope of the present invention, but it should be understood by those skilled in the art that the present invention is not limited thereto, and that the present invention is described in detail with reference to the foregoing examples: any person skilled in the art may modify or easily conceive of the technical solution described in the foregoing embodiments, or perform equivalent substitution of some of the technical features, while remaining within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention, and are intended to be included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (6)
1. The utility model provides a control system of protein separation device in collection urine, is applied to the protein separation device in the collection urine, its characterized in that: the protein separation device comprises:
a frame (100);
the pre-adjusting device (200), the pre-adjusting device (200) comprises a pre-adjusting bin (201), a liquid inlet pipe (207), a sensor (202), a liquid outlet adjusting valve (203) and an original liquid pump (204), the pre-adjusting bin (201) is arranged on a frame (100), the liquid inlet pipe (207) is arranged at the top of the pre-adjusting bin (201), the sensor (202) is used for detecting urine in the pre-adjusting bin (201), the liquid outlet adjusting valve (203) is used for outputting the urine in the pre-adjusting bin (201), the liquid outlet adjusting valve (203) is provided with a first outlet (205) and a second outlet (206), the first outlet (205) is used for discharging the urine in the pre-adjusting bin (201), the second outlet (206) is used for being connected with the original liquid pump (204), and the original liquid pump (204) is used for pressurizing and conveying the urine;
The pre-adjusting device (200) further comprises an adjusting assembly (210) and a cleaning assembly (220), wherein the adjusting assembly (210) is used for adjusting the pH value and the foaming amount of urine in the pre-adjusting bin (201), and the cleaning assembly (220) is used for cleaning the pre-adjusting bin (201) through water injection;
the adsorption device (300), the adsorption device (300) comprises a guide pipe (301), an adsorption column (310), a pressure sensor (302) and a regulating valve (303), the guide pipe (301) is used for connecting the adsorption device (300) and the pre-regulating device (200), the adsorption column (310) is used for adsorbing protein in urine, the pressure sensor (302) is used for detecting the pressure of the urine in the adsorption device (300), and the regulating valve (303) is used for regulating the flow rate of the urine in the adsorption device (300);
the adsorption column (310) comprises an electromagnetic valve (311), a sealing shell (312), a silica gel column (313), a timer (314) and an electromagnetic sleeve (319), wherein the electromagnetic valve (311) is used for opening or closing a channel of the adsorption column (310) so as to control urine to enter the adsorption column (310) or prevent the urine from entering the adsorption column (310), an electromagnetic opening and closing device (316) is arranged on one side of the bottom of the sealing shell (312), an electromagnetic guide rail (318) is arranged on the rack (100), the electromagnetic opening and closing device (316) is arranged on the electromagnetic guide rail (318), an electromagnet (317) is arranged on the outer side of the sealing shell (312), a labyrinth sealing structure (315) for sealing a joint of the sealing shell (312) is arranged on the side edge of the sealing shell (312), the electromagnetic opening and closing device (316) is used for opening or closing the sealing shell (312), and the electromagnetic sleeve (319) is detachably connected with the silica gel column (313);
The adsorption device (300) further comprises: a preparation bin (320) and a storage bin (321), wherein the preparation bin (320) is used for storing unused silica gel columns (313), and the storage bin (321) is used for storing silica gel columns (313) reaching adsorption time;
the adsorption device (300) further comprises a clamping replacement assembly (330), the clamping replacement assembly (330) comprises a mobile vehicle body (340) and a clamping actuator (350), the mobile vehicle body (340) is connected with the frame (100) and is used for moving along the frame (100), a sliding rail (342) is arranged at the bottom of the mobile vehicle body (340), an electric cylinder (343) is arranged on the sliding rail (342), the clamping actuator (350) is arranged on the sliding rail (342), the electric cylinder (343) is used for driving the clamping actuator (350) to move along the sliding rail (342), a hydraulic cylinder (344) is arranged on the clamping actuator (350), the hydraulic cylinder (344) is used for controlling the telescopic movement of the clamping actuator (350), and the clamping actuator (350) is used for clamping a silica gel column (313) in the preparation bin (320) and replacing and installing the silica gel column (313) in the adsorption column (310);
The movable vehicle body (340) is provided with a positioner (341), the positioner (341) is used for positioning the position of the movable vehicle body (340), the clamping actuator (350) comprises a rotating disc (351) and a clamping mechanism (352), the rotating disc (351) is used for rotating the clamping mechanism (352) to align with a silica gel column (313) in the preparation bin (320) or a silica gel column (313) in the adsorption column (310), and the clamping mechanism (352) is used for clamping the silica gel column (313);
the control system comprises a pre-adjusting module and an adsorption module, wherein the pre-adjusting module is used for controlling the pre-adjusting device (200) to pre-adjust input urine, the adsorption module is used for controlling the adsorption device (300) to adsorb the pre-adjusted urine, the pre-adjusting module comprises a detection unit, an adjusting unit, a cleaning unit and a marking unit, and the detection unit acquires the pH value, the temperature and the conductivity of the urine in the pre-adjusting bin (201) through a sensor (202) and outputs a pH value signal, a temperature signal and a conductivity signal;
the regulating unit comprises a regulating strategy, the regulating strategy comprises the steps of acquiring a pH value signal, judging a pH value interval, outputting a liquid discharge instruction if the pH value is larger than a first threshold value or smaller than a second threshold value, opening a first outlet (205) by the liquid outlet regulating valve (203) based on the liquid discharge instruction, discharging urine in the pre-regulating bin (201), and outputting a liquid discharge completion signal; if the pH value is greater than or equal to a second threshold value and less than or equal to a first threshold value, an adjusting instruction is output, the adjusting assembly (210) adjusts the pH value of urine in the pre-adjusting bin (201) based on the adjusting instruction, if the pH value of the urine in the pre-adjusting bin (201) is in a proper interval, an adjusting completion signal and a liquid outlet instruction are output, the liquid outlet adjusting valve (203) opens a second outlet (206) based on the liquid outlet instruction, urine is output to the raw liquid pump (204), and a liquid outlet completion signal is output;
The cleaning unit is used for acquiring a liquid discharge completion signal or a liquid discharge completion signal and outputting a cleaning instruction, the cleaning assembly (220) is used for carrying out water injection cleaning on the pre-adjustment bin (201) based on the cleaning instruction and outputting the cleaning completion signal and the liquid discharge instruction, and the liquid discharge regulating valve (203) is used for opening the first outlet (205) based on the liquid discharge instruction and discharging liquid in the pre-adjustment bin (201);
when the marking unit monitors and acquires the adjustment completion signal, the pH value signal, the temperature signal and the conductivity signal which are output by the detection unit at the moment are acquired, the urine after adjustment is marked, and the marking signal is output.
2. A control system for a protein isolate device for collecting urine as defined in claim 1, wherein: the adsorption module comprises a pressure control unit, the pressure control unit acquires the urine pressure in the adsorption device (300) through a pressure sensor (302), if the pressure is greater than a preset upper limit pressure, a high-pressure signal is output, a regulating valve (303) is controlled to reduce the urine flow rate in the adsorption device (300), if the pressure is lower than a preset lower limit pressure, a low-pressure signal is output, and the regulating valve (303) is controlled to improve the urine flow rate in the adsorption device (300).
3. A control system for a protein isolate device for collecting urine as claimed in claim 2, wherein: the adsorption module further comprises an adsorption column control unit, the adsorption column control unit comprises an adsorption column control strategy, the adsorption column control strategy comprises that the working time of a silica gel column (313) is acquired through a timer (314), if the working time of the silica gel column (313) is larger than the preset time, a replacement signal is output, an electromagnetic valve (311) of the adsorption column (310) is controlled to be closed, urine is prevented from entering the adsorption column (310), an electromagnetic opening and closing device (316) and an electromagnet (317) are controlled to be opened, the joint of a sealing shell (312) is separated through a labyrinth sealing structure (315), the sealing shell (312) is controlled to be opened, the internal silica gel column (313) is exposed, and a position signal of the adsorption column (310) is output.
4. A control system for a protein isolate device for collecting urine as claimed in claim 3, wherein: the adsorption module further comprises a replacement unit, the replacement unit comprises a replacement strategy, the replacement strategy comprises that a coordinate system is established along the frame (100), the position of the preparation bin (320) is taken as an origin of the coordinate system, the coordinate of the mobile vehicle body (340) is obtained through the positioner (341), the mobile vehicle body (340) is controlled to move to the preparation bin (320) along the frame (100) based on the coordinate of the mobile vehicle body (340) and the coordinate of the preparation bin (320), the unused silica gel column (313) in the preparation bin (320) is clamped through the control rotating disc (351) and the clamping mechanism (352), and a clamping completion signal is output; determining the coordinates of the adsorption column (310) in a coordinate system based on the position signals of the adsorption column (310), controlling the movable vehicle body (340) to move to the coordinate position of the adsorption column (310) along the frame (100) based on the coordinates of the adsorption column (310) and the current coordinates of the movable vehicle body (340), controlling the rotary disk (351) to move downwards through the hydraulic cylinder (344), driving the clamping actuator (350) to move on the sliding rail (342) through the electric cylinder (343), aligning the clamping mechanism (352) with the silica gel column (313), clamping the silica gel column (313) reaching the adsorption time through the clamping mechanism (352), controlling the electromagnetic sleeve (319) to shrink so that the silica gel column (313) is separated from the electromagnetic sleeve (319), controlling the clamping mechanism (352) to move downwards so that the silica gel column (313) is separated from the upper guide pipe (301), driving the clamping actuator (350) to move towards the center of the sliding rail (342) through the electric cylinder (343), controlling the rotary disk (351) to rotate, aligning the unused silica gel column (313) with the adsorption column (310) to reach the adsorption time, controlling the clamping mechanism (352) to be aligned with the silica gel column (310), driving the clamping mechanism (313) to be installed in the clamping mechanism (313), the clamping mechanism (352) is controlled to move upwards to enable an unused silica gel column (313) to be connected with the upper flow guide pipe (301) and the electromagnetic sleeve (319) to be connected with the unused silica gel column (313) in an extending mode, after the unused silica gel column (313) is fixed, the clamping mechanism (352) is loosened, the clamping actuator (350) is driven to return to the center of the sliding rail (342) through the electric cylinder (343), the hydraulic cylinder (344) is controlled to control the rotating disc (351) to ascend and return, and a in-place signal is output; the position coordinates of the storage bin (321) are obtained, the mobile vehicle body (340) is controlled to move to the storage bin (321) along the frame (100) based on the current coordinates of the mobile vehicle body (340), a silica gel column (313) reaching the adsorption time is placed in the storage bin (321) through the control rotating disc (351) and the clamping mechanism (352), and a replacement completion signal is output.
5. The control system of a protein separation device for collecting urine according to claim 4, wherein the adsorption column control strategy further comprises the steps of acquiring an in-place signal, controlling the electromagnetic opening and closing device (316) to be closed, sealing the joint of the sealing shell (312) through the labyrinth sealing structure (315), controlling the electromagnet (317) to suck, completing the sealing installation of the silica gel column (313) in the adsorption column (310), controlling the timer (314) to reset and time and controlling the electromagnetic valve (311) of the adsorption column (310) to be opened, conducting the adsorption column (310) to receive urine in the adsorption device (300), and outputting a normal working signal.
6. The control system of claim 5, further comprising a network communication module for transmitting the control system signal to the host computer and receiving the control command from the host computer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311725730.3A CN117398719B (en) | 2023-12-15 | 2023-12-15 | Protein separation device for collecting urine and control system thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311725730.3A CN117398719B (en) | 2023-12-15 | 2023-12-15 | Protein separation device for collecting urine and control system thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN117398719A CN117398719A (en) | 2024-01-16 |
| CN117398719B true CN117398719B (en) | 2024-03-01 |
Family
ID=89498377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311725730.3A Active CN117398719B (en) | 2023-12-15 | 2023-12-15 | Protein separation device for collecting urine and control system thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117398719B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104710505A (en) * | 2015-03-13 | 2015-06-17 | 中国科学院兰州化学物理研究所 | Expanded bed adsorption system for protein separation and recovery |
| CN209451374U (en) * | 2019-01-14 | 2019-10-01 | 郑州伊美诺生物技术有限公司 | The Protein Separation temperature control type affinity chromatography circulatory system |
| CN112179898A (en) * | 2020-09-30 | 2021-01-05 | 柳州市妇幼保健院 | Urine detection system and method |
| CN112891995A (en) * | 2021-01-22 | 2021-06-04 | 宁波环测实验器材有限公司 | Full-automatic adsorption column elution instrument |
| CN215560286U (en) * | 2021-09-06 | 2022-01-18 | 李俊华 | Urokinase collecting equipment |
| CN216629754U (en) * | 2021-12-02 | 2022-05-31 | 金七药业股份有限公司 | Notoginseng draws uses macroporous resin adsorption separation device |
| CN116718713A (en) * | 2023-06-02 | 2023-09-08 | 睿科集团(厦门)股份有限公司 | Automatic identification and treatment method for blocking position of 96-hole solid-phase extraction plate |
-
2023
- 2023-12-15 CN CN202311725730.3A patent/CN117398719B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104710505A (en) * | 2015-03-13 | 2015-06-17 | 中国科学院兰州化学物理研究所 | Expanded bed adsorption system for protein separation and recovery |
| CN209451374U (en) * | 2019-01-14 | 2019-10-01 | 郑州伊美诺生物技术有限公司 | The Protein Separation temperature control type affinity chromatography circulatory system |
| CN112179898A (en) * | 2020-09-30 | 2021-01-05 | 柳州市妇幼保健院 | Urine detection system and method |
| CN112891995A (en) * | 2021-01-22 | 2021-06-04 | 宁波环测实验器材有限公司 | Full-automatic adsorption column elution instrument |
| CN215560286U (en) * | 2021-09-06 | 2022-01-18 | 李俊华 | Urokinase collecting equipment |
| CN216629754U (en) * | 2021-12-02 | 2022-05-31 | 金七药业股份有限公司 | Notoginseng draws uses macroporous resin adsorption separation device |
| CN116718713A (en) * | 2023-06-02 | 2023-09-08 | 睿科集团(厦门)股份有限公司 | Automatic identification and treatment method for blocking position of 96-hole solid-phase extraction plate |
Also Published As
| Publication number | Publication date |
|---|---|
| CN117398719A (en) | 2024-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108969839A (en) | A kind of automatic dressing changing device of more bottles of infusions | |
| CN103983479B (en) | A kind of portable sheet flow sampler of drawer type and the method for sampling thereof | |
| CN102252877B (en) | Full-automatic multichannel air passage switching atmospheric sampling device | |
| CN104302757A (en) | Automated device and automated process for cell culture | |
| CN209237020U (en) | A kind of automatic dressing changing device of more bottles of infusions | |
| US20240036013A1 (en) | Automated solution-phase synthesizer | |
| CN101799396A (en) | Concrete durability water seepage collection instrument | |
| CN105758687A (en) | Deep-sea sediment in-situ cultivation and hermetic sampling mechanism | |
| CN117398719B (en) | Protein separation device for collecting urine and control system thereof | |
| CN108841727A (en) | CAR-T automatic cell preparation system based on micro-fluidic chip | |
| CN205078878U (en) | Water conservancy regulation and control valve | |
| CN203224376U (en) | Rotating back cover type bottom sampler | |
| CN104458139B (en) | Valve sealing test platform | |
| CN106370878B (en) | A kind of negative pressure automatic sampling apparatus for micro-fluidic chip | |
| CN101486965B (en) | Tissue engineering blood vessel bionic incubator | |
| CN104673669A (en) | Microfluidics cell culture system based on micro-carrier and controlling method thereof | |
| CN108611270A (en) | A kind of spatial cell biomechanics experiment system | |
| CN101067615B (en) | Intelligent electric feeding sample device for electric uncoupling chip cataphoresis | |
| CN206096166U (en) | A negative pressure automatic sample introduction device for micro -fluidic chip | |
| CN212357270U (en) | Automatic IVF culture and time difference analysis device and matched culture dish | |
| CN107179273A (en) | A kind of Novel test section blood analyser | |
| CN204695030U (en) | A kind of precision drilling corning machine with drill bit heat sink | |
| CN203881576U (en) | Drawer type portable slope runoff sampler | |
| CN113736655A (en) | Biological cell culture system | |
| CN108104050B (en) | A kind of construction of hydro project automatic drain system based on Internet of Things on-line monitoring |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |