CN117323261A - Anti-aging emulsion and preparation method thereof - Google Patents
Anti-aging emulsion and preparation method thereof Download PDFInfo
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- CN117323261A CN117323261A CN202310036916.1A CN202310036916A CN117323261A CN 117323261 A CN117323261 A CN 117323261A CN 202310036916 A CN202310036916 A CN 202310036916A CN 117323261 A CN117323261 A CN 117323261A
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- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 77
- 239000000839 emulsion Substances 0.000 title claims abstract description 68
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 238000004945 emulsification Methods 0.000 title description 2
- FFNOWYSCJOKVCL-UHFFFAOYSA-N 1-hydroxy-3,3-dimethylbutan-2-one Chemical compound CC(C)(C)C(=O)CO FFNOWYSCJOKVCL-UHFFFAOYSA-N 0.000 claims abstract description 19
- LODWEXDBRZBADB-XEVVZDEMSA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O LODWEXDBRZBADB-XEVVZDEMSA-N 0.000 claims abstract description 18
- 229940094912 palmitoyl tripeptide-5 Drugs 0.000 claims abstract description 18
- 108010016626 Dipeptides Proteins 0.000 claims abstract description 17
- 150000001408 amides Chemical class 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000003906 humectant Substances 0.000 claims abstract description 10
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 8
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 6
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 244000068988 Glycine max Species 0.000 claims abstract description 4
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- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims abstract description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 24
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
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- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 10
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- BYUQATUKPXLFLZ-UIOOFZCWSA-N CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 Chemical group CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 BYUQATUKPXLFLZ-UIOOFZCWSA-N 0.000 claims description 3
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 2
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- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 8
- BXOCHUWSGYYSFW-HVWOQQCMSA-N spilanthol Chemical compound C\C=C\C=C/CC\C=C\C(=O)NCC(C)C BXOCHUWSGYYSFW-HVWOQQCMSA-N 0.000 description 8
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- BXOCHUWSGYYSFW-UHFFFAOYSA-N all-trans spilanthol Natural products CC=CC=CCCC=CC(=O)NCC(C)C BXOCHUWSGYYSFW-UHFFFAOYSA-N 0.000 description 4
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 229940045997 vitamin a Drugs 0.000 description 3
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Landscapes
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- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an anti-aging emulsion and a preparation method thereof, and relates to the field of skin care products. Wherein the anti-aging emulsion comprises a phase A, a phase B and a phase C; phase a includes caprylic/capric triglyceride, shea butter, squalane, organosiloxane, cetostearyl alcohol, hydroxy pinacolone sulfonate, emulsifying agent, and antioxidant; the phase B comprises humectant A, wild soybean seed extract, p-hydroxyacetophenone, thickener and water; phase C includes humectant B, bull's hard oleum Juglandis, herba Portulacae extract, blackberry leaf extract, skin conditioner, dipeptide diamino Ding Xianbian-yl amide diacetate, palmitoyl tripeptide-5, flos Matricariae Chamomillae extract, and pH regulator. The emulsion has the advantages of high anti-aging efficiency, can rapidly improve the facial wrinkle condition, has no stimulation to skin, and can not cause the problems of red spots or local itching.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-aging emulsion and a preparation method thereof.
Background
With the continuous deepening of the aging of the global population, the 'healthy aging' gradually develops into a new consumer market, so that the demands of consumers for anti-aging skin care products are increased.
Wherein, the vitamin A has reliable effect and evidence in anti-aging aspect, and the vitamin A is not ignored when the anti-aging skin care product is prepared. Retinoids, which are structurally and functionally similar to retinol (i.e., vitamin a), are also commonly used in anti-aging skin care products.
Trans retinoic acid is retinoid and has high efficacy in anti-aging, but has the disadvantage of large irritation, and is not suitable for pregnant women. The hydroxy pinacolone retinoic acid ester is a novel retinoid with low cytotoxicity and low irritation. However, under the condition of the same concentration, the hydroxy pinacolone retinoic acid ester has weaker effect on the transcription level than trans-retinoic acid, so that the anti-aging efficiency of the hydroxy pinacolone retinoic acid ester is slower than that of the trans-retinoic acid, and therefore, how to prepare the anti-aging skin care product with excellent anti-aging efficiency and no stimulation by using the hydroxy pinacolone retinoic acid ester has important research significance.
Disclosure of Invention
In order to improve the anti-aging efficiency of the skin care product and reduce the irritation of the skin care product, the application provides an anti-aging emulsion and a preparation method thereof.
In a first aspect, the anti-aging emulsion provided by the application adopts the following technical scheme:
an anti-aging emulsion comprises a phase A, a phase B and a phase C; the phase A comprises 3-10 parts by weight of caprylic/capric triglyceride, 3-10 parts by weight of shea butter, 1-5 parts by weight of squalane, 2-10 parts by weight of organosiloxane, 0.1-1 part by weight of cetostearyl alcohol, 0.1-2 parts by weight of hydroxy pinacolone retinol, 1-5 parts by weight of emulsifier and 0.1-0.5 part by weight of antioxidant;
the phase B comprises 8-28 parts by weight of humectant A, 0.1-1 part by weight of wild soybean seed extract, 0.1-0.8 part by weight of p-hydroxyacetophenone, 0.2-1 part by weight of thickener and 50-80 parts by weight of water;
the phase C comprises 0.21-1.9 parts by weight of humectant B, 0.01-0.5 parts by weight of Boer hard walnut seed oil, 1-3 parts by weight of purslane extract, 0.01-0.5 parts by weight of blackberry leaf extract, 0.11-1.2 parts by weight of skin conditioner, 1-5 parts by weight of dipeptide diamino Ding Xianbian-base amide diacetate, 1-5 parts by weight of palmitoyl tripeptide-5, 1-5 parts by weight of spilanthus altissima extract and 0.1-0.5 parts by weight of pH regulator.
The anti-aging emulsion made of A, B, C three phases has a structure similar to a microcapsule slow release structure of water/oil/water, and can slowly release moisturizing components, so that moisturizing components are continuously supplied to the skin for a long time, waste of the moisturizing components is not caused by instant release, skin is not allergic or irritative uncomfortable due to excessive instant load, and the anti-aging emulsion has the advantage of alleviating and not irritating.
Secondly, the anti-aging emulsion is added with not only the wild soybean seed extract, the berhard walnut seed oil, the purslane extract and the blackberry leaf extract which have the anti-aging effect, but also the hydroxy pinacolone sulfonate, the dipeptide diamino Ding Xianbian-yl amide diacetate, the palmitoyl tripeptide-5 and the spilanthum extract which can synergistically and effectively improve the anti-aging efficiency of the emulsion.
Under the same concentration, the hydroxy pinacolone sulfonate has weaker effect on the gene transcription level than trans-retinoic acid, is stronger than retinol and retinol palmitate, and can promote the synthesis of procollagen. However, at the highest dose of hydroxy pinacolone retinoic acid, hydroxy pinacolone retinoic acid is transcribed at levels superior to trans-retinoic acid and does not induce more inflammation than trans-retinoic acid. However, in view of irritation problems, the dosage of the hydroxy pinacolone sulfonate is not typically maximized.
Dipeptide diamino Ding Xianbian-base amide diacetate is a synthetic peptide simulating snake venom serum, can prevent acetylcholine from combining with muscle cells, achieves the effect of relaxing muscles, and is beneficial to improving dynamic wrinkles;
palmitoyl tripeptide-5 can promote skin cell growth, inhibit oxygen free radicals and hydroxyl free radicals, promote synthesis of matrix proteins, especially collagen, and increase production of elastin, hyaluronic acid, glycosaminoglycan and fibronectin, and can effectively smooth skin fine lines and increase skin elasticity.
The application uses the dipeptide diamino Ding Xianbian-base amide diacetate and palmitoyl tripeptide-5 to be matched with hydroxy pinacolone retinoic acid ester, so that the skin aging problem can be essentially improved.
In addition, in order to improve the anti-aging efficiency, obvious anti-aging effect can be generated after the emulsion is used for a short time, and the spilanthus altissima extract is added. The spilanthum extract has the function of eliminating free radicals and relieving aging. And the spilanthum spicatum extract may also contain substances capable of promoting hydroxy pinacolone retinosulfonate, dipeptide diamino Ding Xianbian-base amide diacetate and palmitoyl tripeptide-5 to play a role, so that quick anti-aging can be realized.
Optionally, 1.5-2 parts by weight of hydroxy pinacolone sulfonate, 1-2 parts by weight of dipeptide diamino Ding Xianbian-base amide diacetate, 2.5-3 parts by weight of palmitoyl tripeptide-5 and 1-2 parts by weight of spilanthum flower extract.
When the proportion of the hydroxy pinacolone retinosulfonate, the dipeptide diamino Ding Xianbian-base amide diacetate, the palmitoyl tripeptide-5 and the spilanthol extract is in the range, the emulsion can generate obvious anti-aging effect in a short time, i.e. the anti-aging efficiency of the emulsion is further improved.
Optionally, the hydroxy pinacolone sulfonate is 1.5 parts by weight, the dipeptide diamino Ding Xianbian-based amide diacetate is 2 parts by weight, the palmitoyl tripeptide-5 is 2.5 parts by weight, and the spilanthum extract is 1 part by weight.
The proportion of hydroxy pinacolone retinosulfonate, dipeptide diamino Ding Xianbian-base amide diacetate, palmitoyl tripeptide-5 and spilanthol extract is within the above range, the anti-aging efficiency of the emulsion is the fastest.
Optionally, the humectant A comprises 3-10 parts by weight of butanediol, 3-10 parts by weight of nicotinamide, 1-5 parts by weight of glycerol and 1-3 parts by weight of glycerol polyacrylate.
The combination of the butanediol, nicotinamide, glycerol and glycerol polyacrylate can improve the moisturizing and water locking effects of the emulsion, and can improve skin problems such as wrinkles, skin peeling, enlarged pores and the like caused by aging or external invasion.
Optionally, the humectant B comprises 0.1-1 parts by weight Patch2O, 0.01-0.1 parts by weight sodium hyaluronate, 0.1-0.8 parts by weight 1, 2-hexanediol.
Optionally, the emulsifier comprises isostearyl alcohol, butanediol cocoate and ethyl cellulose, wherein the weight ratio of the isostearyl alcohol, the butanediol cocoate to the ethyl cellulose is 10: (5-10): (0.1-0.2).
When the weight ratio of isostearyl alcohol, butanediol cocoate to ethylcellulose is within the above range, the stability of the emulsion can be further improved, and the emulsion is favorable for fully playing an anti-aging role.
Optionally, the extraction method of the spilanthus altissima extract comprises the following steps:
crushing dried spilanthum, adding acetic acid solution, soaking at 45-55deg.C for 3-4 hr, and filtering to obtain extract A and residue A; the weight ratio of acetic acid solution to dry weight of spilanthum is (10-15): 1;
drying the filter residue A at 50-60deg.C, adding ethanol solution, ultrasonic soaking at 45-55deg.C for 3-4 hr, and filtering to obtain extractive solution B and filter residue B; the weight ratio of the ethanol solution to the dried filter residue A is (8-10): 1;
mixing the extracting solution A and the extracting solution B according to the weight ratio of (2-3): 1, uniformly mixing, and distilling under reduced pressure to obtain a spilanthum extract; wherein the reduced pressure distillation temperature is controlled at 60-70deg.C, and the pressure is controlled at 1-2kPa.
The spilanthol extract prepared by the method not only can effectively improve the anti-aging efficiency of the emulsion, but also can improve the anti-aging stability of the emulsion.
Optionally, the drying mode of the spilanthum is vacuum freeze-drying, the freeze-drying temperature is less than-40 ℃, and the vacuum degree is 10-30Pa.
The spilanthum is dried by adopting a vacuum freeze-drying mode, so that the effective substances can be reserved to the greatest extent, and the possibility of volatilizing the effective substances due to high temperature can be reduced.
Optionally, the crushed spilanthum is 2-3mm in length.
The crushing length of the spilanthum is controlled to be 2-3mm, so that the spilanthum is convenient to filter on one hand, and the leaching of effective substances can be accelerated on the other hand.
In a second aspect, the preparation method of the anti-aging emulsion provided by the application adopts the following technical scheme:
the preparation method of the anti-aging emulsion comprises the following steps:
adding the phase A raw materials into an oil pan according to the proportion, heating to 85 ℃ and completely dispersing;
adding the phase B raw materials into a water pot according to the proportion, heating to 80-85 ℃ for dissolution;
mixing the substances in the oil pan and the water pan, uniformly stirring, homogenizing at 80-85 ℃, then degassing, cooling to about 48 ℃ at the same time, and obtaining a premix;
adding the C phase raw material into the premix according to the proportion, and uniformly stirring to obtain the anti-aging emulsion.
In summary, the technical solution claimed in the present application at least includes the following beneficial effects:
1. the emulsion has the advantages of high anti-aging efficiency, can quickly improve the facial wrinkle condition, has no stimulation to skin, and can not cause the problems of red spots or local itching;
2. when the spilanthol extract prepared by the specific method is adopted by the emulsion, the anti-aging stability of the emulsion is improved, and long-acting anti-aging can be realized.
Detailed Description
The present application will be described in further detail with reference to specific examples and comparative examples.
Examples
Examples 1 to 3
An anti-aging emulsion comprises the following components in proportion shown in table 1.
TABLE 1 Components and proportions (units/kg) of the anti-aging emulsions of examples 1-3
Wherein the emulsifier consists of 50g of isostearyl alcohol, 100g of butanediol cocoate and 0.5g of ethyl cellulose; the anti-aging component consisted of 0.15kg of bitter orange flower oil, 1.5kg of lavender oil, 1kg of geranium oil and 0.3kg of cream oil.
In addition, the preparation method of the anti-aging emulsion in examples 1 to 3 comprises the following steps:
adding the phase A raw materials into an oil pan according to the proportion, heating to 85 ℃ and completely dispersing;
adding the phase B raw materials into a water pot according to the proportion, heating to 80-85 ℃ for dissolution;
mixing the substances in the oil pan and the water pan, uniformly stirring, homogenizing for 2 hours at 80-85 ℃, then degassing, cooling to about 48 ℃ at the same time, and obtaining a premix;
adding the C phase raw material into the premix according to the proportion, and uniformly stirring to obtain the anti-aging emulsion.
Example 4
An anti-aging emulsion, which differs from example 2 in that:
1.5kg of hydroxy pinacolone retinosulfonate, 1.0kg of dipeptide diamino Ding Xianbian base amide diacetate, 2.0kg of palmitoyl tripeptide-5 and 2.5kg of spilanthum (ACMELLA OLERACEA) extract.
Example 5
An anti-aging emulsion, which differs from example 2 in that:
1.5kg of hydroxy pinacolone retinosulfonate, 2.0kg of dipeptide diamino Ding Xianbian base amide diacetate, 2.5kg of palmitoyl tripeptide-5 and 1.0kg of spilanthum (ACMELLA OLERACEA) extract.
Example 6
An anti-aging emulsion, differing from example 5 in that:
the emulsifier consisted of 100g isostearyl alcohol, 50g butylene glycol cocoate and 1g ethylcellulose.
Example 7
An anti-aging emulsion, differing from example 5 in that:
the emulsifier consists of 100g isostearyl alcohol, 100g butylene glycol cocoate and 5g ethylcellulose.
Example 8
An anti-aging emulsion, which differs from example 6 in that:
the preparation method of the spilanthus altissima (ACMELLA OLERACEA) extract comprises the following steps:
crushing freeze-dried spilanthum to 2-3mm in length, adding acetic acid solution, then carrying out ultrasonic soaking at 50 ℃ for 3.5h, and filtering to obtain an extract A and filter residues A; wherein the freeze-drying temperature of the spilanthum is-50 ℃, and the weight ratio of the acetic acid solution to the spilanthum dry weight is 12:1;
drying the filter residue A at 55 ℃, adding an ethanol solution, carrying out ultrasonic soaking at 50 ℃ for 3.5 hours, and filtering to obtain an extracting solution B and a filter residue B; the weight ratio of the ethanol solution to the dried filter residue A is 9:1;
mixing the extracting solution A and the extracting solution B according to the weight ratio of 2.5:1, and then the reduced pressure distillation temperature is controlled at 70 ℃ and the pressure is controlled at 2KPa, and the spilanthum flower extract is obtained when the volume of the concentrated solution becomes half.
Example 9
An anti-aging emulsion, which differs from example 8 in that:
the preparation method of the spilanthus altissima (ACMELLA OLERACEA) extract comprises the following steps:
crushing lyophilized flos Chrysanthemi to 2-3mm, adding ethanol solution, soaking at 50deg.C for 3.5 hr, and filtering to obtain extractive solution and residue; the freeze-drying temperature of the spilanthum is-50 ℃, and the weight ratio of the ethanol solution to the spilanthum dry weight is 9:1;
distilling under reduced pressure at 70deg.C under pressure of 2KPa until the volume of the concentrated solution becomes half to obtain flos Chrysanthemi extract.
Example 10
An anti-aging emulsion, which differs from example 8 in that:
the preparation method of the spilanthus altissima (ACMELLA OLERACEA) extract comprises the following steps:
crushing lyophilized flos Chrysanthemi to 2-3mm, adding acetic acid solution, soaking at 50deg.C for 3.5 hr, and filtering to obtain extractive solution and residue; the freeze-drying temperature of the spilanthum is-50 ℃, and the weight ratio of the acetic acid solution to the spilanthum dry weight is 12:1; distilling under reduced pressure at 70deg.C under pressure of 2KPa until the volume of the concentrated solution becomes half to obtain flos Chrysanthemi extract.
Example 11
An anti-aging emulsion, which differs from example 8 in that:
the preparation method of the spilanthus altissima (ACMELLA OLERACEA) extract comprises the following steps:
the spilanthum is dried at a high temperature of 100 ℃.
Comparative example
Comparative example 1
The anti-aging emulsion is different from the anti-aging emulsion in the embodiment 2:
the hydroxy pinacolone retinosulfonate was replaced with an equivalent amount of palmitoyl tripeptide-5.
Comparative example 2
The anti-aging emulsion is different from the anti-aging emulsion in the embodiment 2:
dipeptide diamino Ding Xianbian-yl amide diacetate was replaced with an equivalent amount of hydroxy pinacolone retinoic acid ester.
Comparative example 3
The anti-aging emulsion is different from the anti-aging emulsion in the embodiment 2:
palmitoyl tripeptide-5 is replaced with an equivalent amount of hydroxy pinacolone retinosulfonate.
Comparative example 4
The anti-aging emulsion is different from the anti-aging emulsion in the embodiment 2:
the spilanthum extract is replaced by equivalent blackberry leaf extract.
Performance test
1. Stability: and (3) placing the product to be detected in an electric heating constant temperature incubator at 60 ℃ for 90 days, then recovering the product to room temperature, and observing whether the product has the phenomena of oil seepage, water separation, demulsification and the like.
2. Anti-aging Effect test
150 healthy volunteers, of which the ages are 50-60 years, the wrinkle states at the corners of the eyes are similar, and the skin properties are dry skin, are selected, and are equally divided into 15 groups, and the emulsions of the corresponding examples and the comparative examples are used in the morning and evening every day, and the average use time period when the wrinkles at the corners of the eyes are obviously improved (the number of the wrinkles is halved) is recorded.
TABLE 2 emulsion stability and anti-aging efficiency of examples and comparative examples
Combining example 2 with comparative examples 1-4 and combining the data in Table 2, it can be seen that the four of hydroxyppinacolone retinosulfonate, dipeptide diamino Ding Xianbian-yl amide diacetate, palmitoyl tripeptide-5, and spilanthum extract synergistically enhance the anti-aging efficiency of the emulsion and shorten the time of improving wrinkles by the emulsion.
In combination with examples 5-7 and with the data in Table 2, the weight ratio of isostearyl alcohol, butylene glycol cocoate to ethylcellulose was found to be 10: (5-10): when the content is in the range of (0.1-0.2), the stability of the emulsion can be further improved, and the emulsion is favorable for fully playing an anti-aging role.
By combining example 6 with examples 8-11 and combining the data in Table 2, it can be seen that the spilanthum flower extract prepared by the preparation method claimed in the application not only can further improve the anti-aging efficiency of the emulsion, but also can improve the anti-aging stability of the emulsion, so that the emulsion has better anti-aging effect in a short term and a long term.
Claims (10)
1. An anti-aging emulsion, which is characterized in that: comprises a phase A, a phase B and a phase C; the phase A comprises 3-10 parts by weight of caprylic/capric triglyceride, 3-10 parts by weight of shea butter, 1-5 parts by weight of squalane, 2-10 parts by weight of organosiloxane, 0.1-1 part by weight of cetostearyl alcohol, 0.1-2 parts by weight of hydroxy pinacolone retinol, 1-5 parts by weight of emulsifier and 0.1-0.5 part by weight of antioxidant;
the phase B comprises 8-28 parts by weight of humectant A, 0.1-1 part by weight of wild soybean seed extract, 0.1-0.8 part by weight of p-hydroxyacetophenone, 0.2-1 part by weight of thickener and 50-80 parts by weight of water;
the phase C comprises 0.21-1.9 parts by weight of humectant B, 0.01-0.5 parts by weight of Boer hard walnut seed oil, 1-3 parts by weight of purslane extract, 0.01-0.5 parts by weight of blackberry leaf extract, 0.11-1.2 parts by weight of skin conditioner, 1-5 parts by weight of dipeptide diamino Ding Xianbian-base amide diacetate, 1-5 parts by weight of palmitoyl tripeptide-5, 1-5 parts by weight of spilanthus altissima extract and 0.1-0.5 parts by weight of pH regulator.
2. An anti-aging emulsion according to claim 1, wherein: 1.5-2 parts by weight of hydroxy pinacolone retinosulfonate, 1-2 parts by weight of dipeptide diamino Ding Xianbian-base amide diacetate, 2.5-3 parts by weight of palmitoyl tripeptide-5 and 1-2 parts by weight of spilanthus altissima extract.
3. An anti-aging emulsion according to claim 1, wherein: 1.5 parts by weight of hydroxy pinacolone retinosulfonate, 2 parts by weight of dipeptide diamino Ding Xianbian-base amide diacetate, 2.5 parts by weight of palmitoyl tripeptide-5 and 1 part by weight of spilanthum extract.
4. An anti-aging emulsion according to claim 1, wherein: the humectant A comprises 3-10 parts by weight of butanediol, 3-10 parts by weight of nicotinamide, 1-5 parts by weight of glycerol and 1-3 parts by weight of glycerol polyacrylate.
5. An anti-aging emulsion according to claim 1, wherein: the humectant B comprises 0.1-1 weight part of Patch H2O, 0.01-0.1 weight part of sodium hyaluronate and 0.1-0.8 weight part of 1, 2-hexanediol.
6. An anti-aging emulsion according to claim 1, wherein: the emulsifier comprises isostearyl alcohol, butanediol cocoate and ethyl cellulose, wherein the weight ratio of the isostearyl alcohol, the butanediol cocoate to the ethyl cellulose is 10: (5-10): (0.1-0.2).
7. An anti-aging emulsion according to any one of claims 1 to 6, wherein: the extraction method of the spilanthus altissima extract comprises the following steps:
crushing dried spilanthum, adding acetic acid solution, soaking at 45-55deg.C for 3-4 hr, and filtering to obtain extract A and residue A; the weight ratio of acetic acid solution to dry weight of spilanthum is (10-15): 1;
drying the filter residue A at 50-60deg.C, adding ethanol solution, ultrasonic soaking at 45-55deg.C for 3-4 hr, and filtering to obtain extractive solution B and filter residue B; the weight ratio of the ethanol solution to the dried filter residue A is (8-10): 1;
mixing the extracting solution A and the extracting solution B according to the weight ratio of (2-3): 1, uniformly mixing, and distilling under reduced pressure to obtain a spilanthum extract; wherein the reduced pressure distillation temperature is controlled at 60-70deg.C, and the pressure is controlled at 1-2kPa.
8. The anti-aging emulsion of claim 7, wherein: the drying mode of the spilanthum is vacuum freeze-drying, and the freeze-drying temperature is minus 40 ℃.
9. The anti-aging emulsion of claim 7, wherein: the crushed spilanthum is 2-3mm in length.
10. A method for preparing an anti-aging emulsion according to any one of claims 1 to 9, comprising the steps of:
adding the phase A raw materials into an oil pan according to the proportion, heating to 85 ℃ and completely dispersing;
adding the phase B raw materials into a water pot according to the proportion, heating to 80-85 ℃ for dissolution;
mixing the substances in the oil pan and the water pan, uniformly stirring, homogenizing at 80-85 ℃, then degassing, cooling to about 48 ℃ at the same time, and obtaining a premix;
adding the C phase raw material into the premix according to the proportion, and uniformly stirring to obtain the anti-aging emulsion.
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