CN117323257B - Dual-phase facial mask and preparation method thereof - Google Patents
Dual-phase facial mask and preparation method thereof Download PDFInfo
- Publication number
- CN117323257B CN117323257B CN202311634656.4A CN202311634656A CN117323257B CN 117323257 B CN117323257 B CN 117323257B CN 202311634656 A CN202311634656 A CN 202311634656A CN 117323257 B CN117323257 B CN 117323257B
- Authority
- CN
- China
- Prior art keywords
- phase
- humectant
- corn starch
- mask
- acrylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000001815 facial effect Effects 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 230000002051 biphasic effect Effects 0.000 claims abstract description 30
- -1 polyoxyethylene Polymers 0.000 claims description 36
- 229920001577 copolymer Polymers 0.000 claims description 32
- 229920000881 Modified starch Polymers 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 27
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 26
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- 239000003906 humectant Substances 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 19
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims description 14
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims description 14
- 229940107187 fructooligosaccharide Drugs 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 239000003755 preservative agent Substances 0.000 claims description 10
- 230000002335 preservative effect Effects 0.000 claims description 10
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims description 7
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 7
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 7
- 229940068968 polysorbate 80 Drugs 0.000 claims description 7
- 229920000053 polysorbate 80 Polymers 0.000 claims description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 6
- 229920002261 Corn starch Polymers 0.000 claims description 6
- 239000008120 corn starch Substances 0.000 claims description 6
- 238000006011 modification reaction Methods 0.000 claims description 5
- 239000004382 Amylase Substances 0.000 claims description 4
- 102000013142 Amylases Human genes 0.000 claims description 4
- 108010065511 Amylases Proteins 0.000 claims description 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 4
- 235000019418 amylase Nutrition 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 238000004806 packaging method and process Methods 0.000 claims description 4
- 239000004475 Arginine Substances 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- ATMLPEJAVWINOF-UHFFFAOYSA-N acrylic acid acrylic acid Chemical compound OC(=O)C=C.OC(=O)C=C ATMLPEJAVWINOF-UHFFFAOYSA-N 0.000 claims description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical group OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 230000009977 dual effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 24
- 230000003020 moisturizing effect Effects 0.000 abstract description 11
- 230000017531 blood circulation Effects 0.000 abstract description 6
- 238000010521 absorption reaction Methods 0.000 abstract description 5
- 239000002537 cosmetic Substances 0.000 abstract description 4
- 230000004089 microcirculation Effects 0.000 abstract description 3
- 239000012567 medical material Substances 0.000 abstract 1
- 239000012071 phase Substances 0.000 description 109
- 230000000052 comparative effect Effects 0.000 description 40
- 210000003491 skin Anatomy 0.000 description 34
- 239000006260 foam Substances 0.000 description 25
- 238000012360 testing method Methods 0.000 description 24
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- 230000014759 maintenance of location Effects 0.000 description 13
- 230000007794 irritation Effects 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 5
- 229940099112 cornstarch Drugs 0.000 description 5
- 230000000875 corresponding effect Effects 0.000 description 5
- 239000004471 Glycine Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000012795 verification Methods 0.000 description 3
- CLAHOZSYMRNIPY-UHFFFAOYSA-N 2-hydroxyethylurea Chemical compound NC(=O)NCCO CLAHOZSYMRNIPY-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 229940031575 hydroxyethyl urea Drugs 0.000 description 2
- 230000000774 hypoallergenic effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000036561 sun exposure Effects 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 description 1
- 241000235649 Kluyveromyces Species 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 206010051788 Sticky skin Diseases 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- CFAFEJHONLMPQY-UHFFFAOYSA-N beta-Dimethylamino-aethan-alpha-sulfonsaeure Natural products CN(C)CCS(O)(=O)=O CFAFEJHONLMPQY-UHFFFAOYSA-N 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- REEZZSHJLXOIHL-UHFFFAOYSA-N octanoyl chloride Chemical compound CCCCCCCC(Cl)=O REEZZSHJLXOIHL-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
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- 239000006041 probiotic Substances 0.000 description 1
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- 230000035755 proliferation Effects 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000008326 skin blood flow Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
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- 238000003860 storage Methods 0.000 description 1
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- 230000008719 thickening Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a biphase facial mask and a preparation method thereof, belonging to the technical field of medical material cosmetics; according to the biphasic facial mask provided by the invention, the phase A and the phase B with proper mass percentages are selected and compounded to be used, so that stable bubbles can be generated, the duration of the bubbles is long, the use experience is good, the skin microcirculation can be quickened, the blood flow of the skin is improved, and the absorption of functional components is promoted; the bubble mask provided by the invention can maintain a longer-term moisturizing effect and an oil control effect after being used; meanwhile, the quality guarantee period of the mask is long.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a biphasic facial mask and a preparation method thereof.
Background
The facial mask is a kind of skin care product, is used for moisturizing skin, and also has multiple functions of moisturizing, nourishing, improving appearance, deep cleaning and the like. The mask may be classified according to its efficacy on skin, type of skin applied, form of mask, etc. The most common classifications are in the form of masks, which can be classified into peeling, wiping or washing, peeling after curing, and main stream sticking according to the form of mask. Among them, the bubble mask is widely popular because it can be covered on the skin in a bubble form when in use, due to the specificity of the form.
The existing two-phase facial mask paste on the market comprises simple film-liquid separation package, powder, essence and film-cloth three-phase separation package, and the actual appearance is mainly based on package innovation; in addition, the liquid phase and the powder which are popular in the market are separated, a large amount of bubbles can be generated by mixing the liquid phase and the powder before use, and carbon dioxide is released, but the powder has the defects of sticky skin feel and heavy feel; therefore, the phenomenon of water loss of the skin after the application of the skin is caused, and the skin is seriously oiled due to the strong feeling of tightness and weight.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a biphasic facial mask which can generate stable and dense bubbles, has excellent moisturizing performance and oil control performance, low irritation and long shelf life and a preparation method thereof.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: a bi-phase mask comprising an a-phase and a B-phase;
the phase A comprises the following components in percentage by mass: 0.1-10% of modified corn starch, 0.1-10% of polyoxyethylene, 0.1-7% of acrylic acid-acrylic ester copolymer, 0.1-10% of sodium bicarbonate, 0.1-20% of humectant, 0.1-5% of pH regulator, 0-0.5% of preservative and the balance of water;
the phase B comprises the following components in percentage by mass: 1-10% of acrylic acid TEA salt/acryloyldimethyl taurine TEA salt copolymer, isohexadecane, polysorbate-80, 0.1-20% of humectant, 0.1-20% of fructo-oligosaccharide, 0.5-10% of octanoylglycine, 0.5-6% of citric acid and the balance of water;
the modified corn starch is a product obtained by adding amylase into a corn starch aqueous solution for modification reaction.
The biphasic facial mask provided by the invention comprises a phase A and a phase B which contain proper mass percentage components, and the two phases are in a liquid state, so that the two phases are compounded and used, and on the basis of being capable of generating a dense and stable bubble, no smoky feeling appears, but skin pores can be opened, namely cells are fully breathed, the biphasic facial mask has good use experience, and the 'Bohr effect' generated in the use process can accelerate microcirculation of skin, promote blood flow of skin, thereby promoting absorption of functional components, obtaining excellent moisture retention and oil control, and also has the effect of promoting absorption of the functional components in other skin care products after use; meanwhile, the quality guarantee period of the mask is long. Specifically, in the facial mask A phase, the modified corn starch, the polyoxyethylene and the acrylic acid-acrylic ester copolymer have excellent effect of stabilizing a system, and can help to realize the tightness, uniformity and stability of foam, so that the user experience is improved, and the stable foam can also help to realize good moisturizing and oil control effects of the product on skin; meanwhile, after the phase A and the phase B are mixed, the acrylic acid TEA salt/acrylic acid dimethyl taurine TEA salt copolymer in the phase B and isohexadecane and polysorbate-80 can also be matched with corn starch, polyoxyethylene and acrylic acid-acrylic ester copolymer to further realize the stability of foam; the fructo-oligosaccharide and the octanoylglycine in the phase B have good compounding effect in the bubble maintaining system, and can better exert the effects of the fructo-oligosaccharide and the octanoylglycine, thereby obtaining excellent moisture retention and oil control.
As a preferred embodiment of the biphasic facial mask of the present invention, the a phase comprises the following components in percentage by mass: 2-8% of modified corn starch, 0.5-4% of polyoxyethylene, 2-6% of acrylic acid-acrylic ester copolymer, 6-9% of sodium bicarbonate, 0.1-20% of humectant, 0.1-5% of pH regulator, 0.1-0.5% of preservative and the balance of water;
the phase B comprises the following components in percentage by mass: 3-8% of acrylic acid TEA salt/acryloyldimethyl taurine TEA salt copolymer, 0.1-20% of humectant, 1-8% of fructo-oligosaccharide, 3-8% of octanoylglycine, 1-5% of citric acid and the balance of water.
Preferably, the phase A comprises the following components in percentage by mass: 4% of modified corn starch, 2% of polyoxyethylene, 4% of acrylic acid-acrylic ester copolymer, 8% of sodium bicarbonate, 3% of humectant, 3.8% of pH regulator, 0.2% of preservative and the balance of water;
the phase B comprises the following components in percentage by mass: 5% of acrylic acid TEA salt/acryloyldimethyl taurate TEA salt copolymer, isohexadecane and polysorbate-80, 15% of humectant, 2% of fructo-oligosaccharide, 5% of octanoylglycine, 3% of citric acid and the balance of water.
According to the invention, the research shows that the mass percentages of the A phase and the B phase in the bubble mask can influence the comprehensive performance of the product, and when the mass percentages of the components are further selected within the preferred ranges, particularly the preferred point values, the comprehensive effect of the obtained product is more excellent.
As a preferred embodiment of the biphasic facial mask of the invention, the mass ratio of the modified corn starch, the polyoxyethylene and the acrylic acid-acrylic ester copolymer is 1: (0.3-0.7): (0.7-1.2).
According to the invention, the research shows that the mass ratio of the modified corn starch, the polyoxyethylene and the acrylic acid-acrylic ester copolymer in the phase A can obviously influence the stability and the compactness of subsequent bubbles, and when the mass ratio of the modified corn starch, the polyoxyethylene and the acrylic acid-acrylic ester copolymer is further selected to be within the range of the invention, the obtained foam has more excellent stability and better 'Bohr effect', so that the synergy of the efficacy components is promoted to obtain good moisture retention and oil control.
As a preferred embodiment of the biphasic facial mask of the present invention, the mass ratio of fructo-oligosaccharide and octanoylglycine is 1: (2-4).
The fructo-oligosaccharide has moisture retention, and the fructo-oligosaccharide can be introduced into the biphasic facial mask system to achieve the moisture retention effect, and can be compounded with octanoylglycine to achieve the purpose of effectively relieving and controlling oil on skin.
As a preferred embodiment of the biphasic facial mask of the present invention, the polyoxyethylene has an average molecular weight of 1000-2000 kDa.
According to the research of the invention, the average molecular weight of polyoxyethylene can influence the comprehensive performance of the product, and when the average molecular weight of polyoxyethylene is further selected to be 1000-2000 kDa, the stability and the compactness of foam can be better; and the obtained product has more excellent moisture retention and oil control.
In one embodiment, the polyoxyethylene is WSR N-12K NF, and the average molecular weight of the WSR N-12K NF is 1000 kDa. The polyoxyethylene can be selected to establish a good synergistic effect with the modified corn starch and the acrylic acid-acrylic ester copolymer, so that the stability of foam is obtained, and good use experience is obtained.
In one embodiment, the modified corn starch is BAFEORII ® CM66. The modified corn starch is a product obtained by adding amylase into a corn starch aqueous solution for modification reaction, and the specific preparation process comprises the following steps: adding sodium hydroxide into the prepared corn starch aqueous solution to adjust the pH value, then adding amylase to carry out modification reaction, adding citric acid to adjust the pH value after the modification reaction is finished, filtering, collecting filter residues, drying and sterilizing to obtain the modified corn starch. When the modified corn starch is selected, the modified corn starch has good thickening property and ion resistance, can establish good synergistic effect with polyoxyethylene and acrylic acid-acrylic ester copolymer, obtains the stability of foam, and obtains good use experience.
In one embodiment, the acrylic acid-acrylate copolymer is SF-1. The acrylic acid-acrylic ester copolymer has good suspension property and ion resistance, can effectively stabilize the phase A component, and simultaneously, can be cooperated with modified corn starch and polyoxyethylene to stabilize bubbles generated by the reaction of citric acid and sodium bicarbonate after the phase A and the phase B are mixed.
In one embodiment, the fructooligosaccharides are BAFEORII ® AML P0. The invention discovers that the fructo-oligosaccharide is obtained by adopting natural fructo-oligosaccharide through enzyme digestion, the high moisturizing capability of the natural fructo-oligosaccharide is reserved, the sticky feeling of skin is reduced, the skin microecology can be regulated, and the growth of probiotics is promoted; meanwhile, the water-soluble polymer can be compounded with octanoylglycine to obtain excellent effects of relieving, controlling oil and keeping moisture.
In one embodiment, the TEA acrylate/Acryldimethyltaurine TEA salt copolymer and isohexadecane and polysorbate-80 are BAFEORII ® SAT 30G. The invention has found that the BAFEORII is specifically selected ® SAT 30G, which is excellent in acid resistance, can exist stably in various systems, does not need to be neutralized when used in a formula, is excellent in stability, is non-irritating, is excellent in skin-friendly, and is soft and comfortable; the modified corn starch in the phase A, polyoxyethylene and acrylic acid-acrylic ester copolymer can be matched to realize the stability, uniformity and compactness of the bubble; specifically, after mixing phase A and phase B, the citric acid and sodium bicarbonate react to form a salt, and part of octanoylglycine also forms a salt, and BAFEORII is added ® SAT 30G is not ion-resistant, and thus becomes physically thin; is favorable for coating, uniformity and compactness of system foam, and can not cause skin feel clunk after coating.
In one embodiment, the octanoylglycine is BAFEORII ® U7G. According to the research of the invention, the selected octanoyl glycine is synthesized from lipophilic octanoyl chloride and hydrophilic glycine, and is used as a biological carrier of glycine, and the octanoyl glycine has an amphiphilic structure and has good skin-friendly property; octanoylglycine is the main component of dermis structural protein, and can regulate acid-base balance of skin and establish acid barrier by providing free carboxylic acid molecules; meanwhile, the composition can inhibit the activity of 5 alpha-reductase, limit excessive secretion of grease and inhibit proliferation of bacteria which cause acne skin to be easy to generate, so that an effective oil control effect is achieved.
As a preferred embodiment of the biphasic facial mask of the present invention, the humectant in the phase a is at least one selected from glycerin, butylene glycol and propylene glycol;
and/or the pH regulator is at least one selected from arginine, aminomethylpropanol and triethanolamine;
and/or the preservative is selected from phenoxyethanol.
Preferably, the humectant in phase a is selected from butylene glycol;
and/or the pH adjuster is selected from arginine.
As a preferred embodiment of the two-phase mask of the present invention, the humectant in the B phase is at least one selected from glycerin, butylene glycol and propylene glycol.
Preferably, the humectant in the phase B is selected from butylene glycol.
In a second aspect of the present invention, the present invention provides a method for preparing the biphasic facial mask, the method comprising the steps of:
(1) Preparation of phase A: mixing part of modified corn starch, part of humectant and part of water, adding polyoxyethylene and acrylic acid-acrylic ester copolymer, stirring for dispersion, heating to 80-90 ℃, and preserving heat for 20-40min; then adding a pH regulator, stirring and dispersing, and cooling to room temperature; then adding the rest part of modified corn starch, the rest part of humectant and the rest part of water which are premixed at 80-90 ℃; then cooling to 40-50 ℃, adding preservative, stirring and dispersing; finally cooling to 35-38 ℃, adding sodium bicarbonate, stirring uniformly, and filling to obtain a phase A;
(2) Preparation of phase B: homogenizing the composition in phase B at normal temperature, and packaging to obtain phase B.
Preferably, the partially modified corn starch comprises 40-70% of the total corn starch; the part of the humectant accounts for 30-60% of the total amount of the humectant; the partial water accounts for 50-80% of the total water.
In a third aspect of the present invention, the present invention provides a method for using the dual-phase mask, wherein the method comprises the steps of mixing phase a and phase B in a ratio of 1: (0.5-1.5) and then is applied to the face after mixing.
The present invention has found that when phase a and phase B are combined at 1: when the mass ratio of (0.5-1.5) is mixed for use, the stability and the persistence of the formed bubbles can be ensured, and the stimulation to the skin caused by any excessive amount can be avoided.
Compared with the prior art, the invention has the beneficial effects that:
according to the biphasic facial mask provided by the invention, the phase A and the phase B with proper mass percentages are selected and compounded to be used, so that stable bubbles can be generated, the duration of the bubbles is long, the use experience is good, the skin microcirculation can be quickened, the blood flow of the skin is improved, and the absorption of functional components is promoted; the bubble mask provided by the invention can maintain a longer-term moisturizing effect and an oil control effect after being used; meanwhile, the quality guarantee period of the mask is long.
Drawings
Fig. 1 is a graph showing the results of mixing the a phase and the B phase of the biphasic mask of example 1.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
The reagents, methods and apparatus employed in the present invention are those conventional in the art unless otherwise indicated.
The INCI names of the partial components used in the examples and comparative examples of the present invention and the trade names of the raw materials are shown in table 1;
TABLE 1
Examples 1 to 9 and comparative examples 1 to 5
Examples 1-9 and comparative examples 1-5 of the present invention provide a two-phase mask comprising a phase a and a phase B, the mass percentages of the components of the phase a and the phase B being shown in table 2;
TABLE 2
The preparation method of the biphasic facial mask shown in the embodiment 1 comprises the following steps:
(1) Preparation of phase A: mixing 50% of modified corn starch, 50% of humectant and 50% of water, adding polyoxyethylene and acrylic acid-acrylic ester copolymer, stirring for dispersion, heating to 85 ℃, and preserving heat for 30min; then adding a pH regulator, stirring and dispersing, and cooling to room temperature; then adding the rest part of modified corn starch, the rest part of humectant and the rest part of water which are premixed at 85 ℃; then cooling to 45 ℃, adding preservative, stirring and dispersing; finally cooling to 35-38 ℃, adding sodium bicarbonate, stirring uniformly, and filling to obtain a phase A;
(2) Preparation of phase B: homogenizing the composition in phase B at normal temperature, and packaging to obtain phase B.
The preparation methods of the two-phase masks in examples 2-9 and comparative examples 1-5 were consistent with example 1, and were not added if there were no relevant components.
Comparative example 6
The comparative example of the present invention provides a two-phase mask which differs from example 1 only in that cellulose is substituted for modified cornstarch in phase a.
Comparative example 7
The comparative example of the present invention provides a two-phase mask which differs from example 1 only in that the acrylic-acrylate copolymer is replaced by xanthan gum in the a phase.
Comparative example 8
The comparative example of the present invention provides a biphasic facial mask which differs from example 1 only in that poloxamer 407 is used in the B phase instead of the acrylic acid TEA salt/acryloyldimethyl taurate TEA salt copolymer and isohexadecane and polysorbate-80.
Comparative example 9
The comparative example of the present invention provides a biphasic mask which differs from example 1 only in that beta-glucan is substituted for fructooligosaccharides in phase B.
Comparative example 10
The comparative example of the present invention provides a biphasic mask which differs from example 1 only in that azelaic acid is substituted for octanoylglycine in phase B.
Comparative example 11
The comparative example of the present invention provides a two-phase mask, which differs from example 1 only in that sodium carbonate is used instead of sodium bicarbonate in phase B.
Effect example
The efficacy of the biphasic facial mask prepared in the examples and comparative examples is verified by the effect example of the invention, and the efficacy comprises the following aspects:
1. irritation of biphasic facial mask
The irritation of the biphasic masks prepared in examples 1 to 9 and comparative examples 1 to 11 prepared by using the plaque test was verified, specifically: selecting 30 volunteers with ages of 20-50 years old, numbering the holes of the spot testers, and respectively placing the sample (the sample after mixing and stirring the A phase and the B phase for 30s according to the mass ratio of 1:1) into the holes of the spot testers with the corresponding numbers, wherein the dosage is 0.02 per cell mL; applying the patch test with the test substance on the skin of the arm of the subject with hypoallergenic tape, applying the patch test on the skin uniformly by lightly pressing with palm, removing the patch test after 24-h, observing skin condition of the wound site, and identifying the standard as shown in table 3;
TABLE 3 Table 3
In the irritation verification result, 2 cases of 2-level reactions and 2 cases of 3-level reactions exist in the two-phase facial mask patch experiment prepared in the comparative example 10, 2 cases of 1-level reactions and 1 case of 2-level reactions exist in the two-phase facial mask patch experiment prepared in the comparative example 11, and 30 of the rest two-phase facial mask patch experiment results are all negative reactions; the biphasic facial mask obtained by the preparation method provided by the invention has small irritation and meets the requirement of no irritation.
As can be seen from example 1 and comparative example 10, when azelaic acid, which also has an oil control effect, is used instead of octanoylglycine, the irritation of the resulting biphasic film increases; as can be seen from example 1 and comparative example 11, when sodium carbonate is used as an alkaline substance instead of sodium bicarbonate, sodium carbonate can also react with an acidic component in a pack formulation to generate carbon dioxide, but is too irritating.
In addition, the A phase and the B phase prepared in the embodiment 1 are respectively mixed according to different mass ratios, and then are subjected to irritation verification, wherein the mass ratios of the A phase and the B phase are respectively 1:0.2, 1:0.5, 1:1.5 and 1:2; the method comprises the following steps: selecting 30 volunteers with ages of 20-50 years old, numbering the holes of the spot testers, and respectively putting the sample (the sample obtained by mixing and stirring the first mask agent and the second mask agent according to the mass ratio for 30 s) into the holes of the spot testers with corresponding numbers, wherein the dosage is 0.02 per cell mL; applying the patch test with the test object on the skin of the arm of the subject by using a hypoallergenic tape, uniformly applying the patch test on the skin by using a palm light pressure, removing the patch test after lasting 24h, and observing the skin condition of the wound part; when the mass ratio of the phase A to the phase B is 1:0.2 and 1:2, 2 cases of 1-level reactions exist in the patch experiments, 1 case of 2-level reactions exist, and the rest 30 people are negative reactions; it is explained that the mass ratio of phase a and phase B also affects the irritation of the product to some extent.
2. Foam Properties
Because the two-phase masks prepared in comparative examples 10 and 11 are too strong in irritation and cannot be practically used, the two-phase masks prepared in comparative examples 10-11 are not subjected to foam performance investigation when foam performance is investigated, i.e., the effect is investigated on the foam performance of the two-phase masks prepared in examples 1-9 and comparative examples 1-9; mixing the phase A and the phase B, adding the mixture into a Kluyveromyces foam instrument, stirring the mixture for 30 seconds at a stirring speed of 50rpm by adopting a stirring method, and then testing corresponding data; starting timing after stirring is stopped, recording the number of bubbles (defined as abundance) and the maximum foam volume in each square millimeter at 0min, then recording the maximum foam volume at 15min, and calculating the foam volume change rate at 0min and 15min, wherein the volume change rate is = (0 min maximum foam volume-15 min maximum foam volume)/0 min maximum foam volume is 100%;
the results obtained from the test are shown in Table 4;
TABLE 4 Table 4
As can be seen from Table 4, when the technical scheme of the present invention is adopted, the obtained product has excellent comprehensive effects, wherein the obtained biphasic facial mask has rich foam and excellent stability, and in particular, the foam abundance of the obtained product is 9.8/mm 2 The volume change rate of 15min is below 23 percent;
it can be seen from examples 1 to 7 that the percentages by mass of the components and the mass ratios between the components have an effect to some extent on the stability and the consistency of the foam; it can be seen from examples 1 and 8-9 that the specific characteristics of the components also affect the foam properties; as can be seen from example 1 and ratio 1, the mass ratio of the phase a to the phase B during use also has an effect on the foam properties of the product;
as can be seen from example 1 and comparative examples 3 to 7, when the modified corn starch, the polyoxyethylene or the acrylic acid-acrylic acid ester copolymer is absent in the a phase, or other similar components are used for respectively replacing the modified corn starch, the polyoxyethylene or the acrylic acid-acrylic acid ester copolymer, the bubble stability of the obtained product is obviously reduced, so that the phenomenon of dripping occurs in the using process, and the using experience of users is reduced; as can be seen from example 1 and comparative example 8, when the acrylic acid TEA salt/acryloyldimethyl taurate TEA salt copolymer and isohexadecane and polysorbate-80 in the B phase were replaced with other similar components, the stability of the resultant product bubbles was also significantly reduced;
wherein, the two-phase mask prepared in example 1 is mixed in the packaging bag as shown in fig. 1, and as apparent from fig. 1, a large amount of bubbles can be generated after the two phases are mixed.
3. Moisture retention and oil control properties
Because the dual-phase mask prepared in comparative examples 10-11 was too irritating, the dual-phase mask prepared in comparative examples 3-8 was too stable to foam, and the performance of the above-mentioned comparative examples was not verified; namely, only the moisturizing performance and the oil control performance of the bubble masks prepared in examples 1 to 9 and comparative examples 1 to 2 and comparative example 9 were verified;
1) Moisture retention performance: 65 healthy subjects aged 18-25 years were enrolled and divided into 13 groups of 5 persons each; after face cleaning, the biphasic facial mask prepared in examples 1-9, comparative examples 1-2 and comparative example 9 is smeared on the face of each group of volunteers (the A phase and the B phase are mixed and stirred for 30s according to the mass ratio of 1:1 and then are coated on the face, and the A phase and the B phase prepared in example 1 are mixed and stirred for 30s according to the mass ratio of 1:1.5 (the mass ratio of 1)), the quality of the smeared facial mask is kept consistent, the smeared facial mask is washed and dried by clear water after 15min, the percutaneous water loss of 2h after use is recorded, the test environment temperature is 20-22 ℃ and the humidity is 40-60%; then keep using 1 every three days; long-time sun exposure, outdoor exercises, travel and the like are not carried out in the whole test period, and the method is not applicable to other moisturizing products or cosmetics, medicines and the like, and does not change the usual daily care habit; testing on the 14 th day and the 28 th day, wherein the testing environment temperature is 20-22 ℃ and the humidity is 40-60%; wherein the rate of change of transdermal water loss = (amount of transdermal water loss after use-amount of transdermal water loss before use)/amount of transdermal water loss before use is 100%; the data obtained are shown in Table 5;
2) Oil control performance: 65 subjects aged 18-25 years healthy with facial symptoms associated with oil appearance were enrolled in 13 groups of 5 persons each; after face cleaning, the biphasic facial mask prepared in examples 1-9, comparative examples 1-2 and comparative example 9 is smeared on the face of each group of volunteers (the A phase and the B phase are mixed and stirred for 30s according to the mass ratio of 1:1 and then are coated on the face, and the A phase and the B phase prepared in example 1 are mixed and stirred for 30s according to the mass ratio of 1:1.5 (the mass ratio of 1)), the quality of the smeared facial mask is kept consistent, the smeared facial mask is washed and dried by clear water after being kept for 15min, the grease content of 2h after being used is recorded, the testing environment temperature is 20-22 ℃ and the humidity is 40-60%; then keep using 1 every three days; long-time sun exposure, outdoor exercises, travel and the like are not performed in the whole test period, and the method is not applicable to other oil control products or cosmetics, medicines and the like, and does not change the usual daily care habit; testing on the 14 th day and the 28 th day, wherein the testing environment temperature is 20-22 ℃ and the humidity is 40-60%; wherein the oil change rate = (oil content after use-oil content before use)/oil content before use is 100%; the data obtained are shown in Table 5;
TABLE 5
As can be seen from table 5, when the technical scheme of the present invention is adopted, the obtained product has excellent moisturizing performance and oil control performance, wherein in the moisturizing performance, the rate of change of the percutaneous water loss after use for 2 hours is reduced by more than 13.85%, and the rate of change of the percutaneous water loss after use for 28 days is reduced by more than 11.68%; in the oil control performance, the oil content is reduced by more than 9.99% after 2 hours of use, and the oil content is reduced by more than 15.12% after 28 days of use;
as can be seen from examples 1 to 7 and comparative examples 1 to 2, the mass percentages of the components and the mass ratio between the components affect the moisture retention and the oil control to some extent, which means that the components have a mutual relationship, and when the mass percentages of the modified corn starch, the polyoxyethylene and the acrylic acid-acrylic ester copolymer in comparative example 1 are too large, the moisture retention is excellent in a short period but shows a significant decrease trend in a long period, and the oil control is weak in both short and long periods; when the mass percentage of the octanoylglycine and the fructo-oligosaccharide added in the comparative example 2 is not in the range of the invention, the obtained product has a certain short-term moisture retention and oil control property, but has poor long-term moisture retention and oil control effect; as can be seen from example 1 and comparative example 9, when other similar substances were used instead of fructooligosaccharides, good moisture retention could not be obtained, and oil control showed a significant decrease in tendency.
4. "Bohr effect" verification
45 healthy subjects aged 18-25 years were enrolled and divided into 9 groups of 5 persons each; after cleaning the face, smearing the biphasic facial mask prepared in examples 1-9 on the face of each group of volunteers (coating the facial mask after mixing and stirring the A phase and the B phase for 30s in a mass ratio of 1:1), keeping the quality of the smeared facial mask consistent, and cleaning and drying the facial mask with clear water after keeping for 15 min; before and after The mask is used, testing The blood flow of facial skin by using a thermo-orildi 2-BI dual-wavelength laser Doppler blood flow meter, wherein The testing environment temperature is 20-22 ℃ and The humidity is 40-60%; the blood flow of the facial mask is improved to different degrees by the products prepared by using the embodiments 1-9 of the invention, and the improvement range is more than 30%. The two-phase mask provided by the invention can realize excellent 'Bohr effect' on the basis of generating carbon dioxide, so that the absorption of efficacy components can be promoted.
Further selecting 15 healthy subjects aged 18-25 years, and dividing the subjects into 3 groups of 5 persons each; after cleansing the face, the biphasic facial mask prepared in example 1 was applied to the face of the first group of volunteers (phase a and phase B were mixed and stirred at a mass ratio of 1:1 for 30s and then applied to the face), left for 15min, then rinsed with clear water and wiped dry, followed by the use of 10% hv50 (hydroxyethylurea solution), the use of 10% hv50 (hydroxyethylurea solution) after cleansing the face, and deionized water after cleansing the face of the third group; the amounts of solutions used in groups 1-3 remained consistent; testing the corresponding skin moisture content change rate at 30min, 1h, 2h, 3h, wherein the skin moisture content change rate = (skin moisture content after use-skin moisture content before use)/skin moisture content before use is 100%; the results obtained are shown in Table 6;
TABLE 6
As can be seen from table 6, after the mask of the present invention is used, pores can be opened and skin blood flow can be promoted, so that penetration of functional components of the subsequent skin care product can be promoted, and corresponding effects can be enhanced.
5. Storage stability
Respectively testing stability of the phase A and the phase B prepared in the examples 1-9, respectively taking samples, standing for 90 days at normal temperature, standing for 30 days at 48 ℃, standing for 30 days at minus 15 ℃ and directly irradiating for 30 days in sunlight, wherein layering does not occur in the test process, and no color change phenomenon which can be observed by naked eyes exists; in addition, the sample is taken and circulated for 7 periods (placed for 24 hours under each temperature system) at the temperature of-15 ℃ to normal temperature to 48 ℃, and layering and color change phenomena cannot be observed by naked eyes; namely, the product prepared by the invention has excellent stability.
Finally, it should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the invention, and that those skilled in the art will understand that changes can be made to the technical solutions of the invention or equivalents thereof without departing from the spirit and scope of the technical solutions of the invention.
Claims (7)
1. A bi-phase mask comprising an a phase and a B phase;
the phase A comprises the following components in percentage by mass: 0.1-10% of modified corn starch, 0.1-10% of polyoxyethylene, 0.1-7% of acrylic acid-acrylic ester copolymer, 0.1-10% of sodium bicarbonate, 0.1-20% of humectant, 0.1-5% of pH regulator, 0-0.5% of preservative and the balance of water;
the phase B comprises the following components in percentage by mass: 1-10% of acrylic acid TEA salt/acryloyldimethyl taurine TEA salt copolymer, isohexadecane, polysorbate-80, 0.1-20% of humectant, 0.1-20% of fructo-oligosaccharide, 0.5-10% of octanoylglycine, 0.5-6% of citric acid and the balance of water;
the modified corn starch is a product obtained by adding amylase into a corn starch aqueous solution for modification reaction;
the average molecular weight of the polyoxyethylene is 1000-2000 kDa;
the using method of the biphase facial mask comprises the steps of mixing phase A and phase B in a ratio of 1: (0.5-1.5) and then is applied to the face after mixing.
2. The bi-phase mask of claim 1, wherein the a phase comprises the following components in mass percent: 2-8% of modified corn starch, 0.5-4% of polyoxyethylene, 2-6% of acrylic acid-acrylic ester copolymer, 6-9% of sodium bicarbonate, 0.1-20% of humectant, 0.1-5% of pH regulator, 0.1-0.5% of preservative and the balance of water;
the phase B comprises the following components in percentage by mass: 3-8% of acrylic acid TEA salt/acryloyldimethyl taurine TEA salt copolymer, 0.1-20% of humectant, 1-8% of fructo-oligosaccharide, 3-8% of octanoylglycine, 1-5% of citric acid and the balance of water.
3. The biphasic facial mask of claim 1, wherein the mass ratio of modified corn starch, polyoxyethylene, acrylic acid-acrylic acid ester copolymer is 1: (0.3-0.7): (0.7-1.2).
4. The biphasic facial mask of claim 1, wherein the mass ratio of fructo-oligosaccharides to octanoylglycine is 1: (2-4).
5. The dual phase mask of claim 1, wherein the humectant in phase a is selected from at least one of glycerin, butylene glycol, propylene glycol;
and/or the pH regulator is at least one selected from arginine, aminomethylpropanol and triethanolamine;
and/or the preservative is selected from phenoxyethanol.
6. The dual phase facial mask of claim 1, wherein said humectant in phase B is selected from at least one of glycerin, butylene glycol, propylene glycol.
7. The method of preparing a bi-phase mask according to any one of claims 1 to 6, comprising the steps of:
(1) Preparation of phase A: mixing part of modified corn starch, part of humectant and part of water, adding polyoxyethylene and acrylic acid-acrylic ester copolymer, stirring for dispersion, heating to 80-90 ℃, and preserving heat for 20-40min; then adding a pH regulator, stirring and dispersing, and cooling to room temperature; then adding the rest part of modified corn starch, the rest part of humectant and the rest part of water which are premixed at 80-90 ℃; then cooling to 40-50 ℃, adding preservative, stirring and dispersing; finally cooling to 35-38 ℃, adding sodium bicarbonate, stirring uniformly, and filling to obtain a phase A;
(2) Preparation of phase B: homogenizing the composition in phase B at normal temperature, and packaging to obtain phase B.
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| CN114306131A (en) * | 2022-01-27 | 2022-04-12 | 广州百孚润化工有限公司 | Washing composition based on modified corn starch and preparation method thereof |
| CN115381736A (en) * | 2022-09-28 | 2022-11-25 | 广州百孚润化工有限公司 | Eye cream composition and preparation method thereof |
| CN116370320A (en) * | 2023-04-17 | 2023-07-04 | 董业清 | Ecological soft mud film and preparation method thereof |
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| US20040161435A1 (en) * | 2003-02-14 | 2004-08-19 | Gupta Shyam K. | Skin Firming Anti-Aging Cosmetic Mask Compositions |
| DE102009045933A1 (en) * | 2009-10-22 | 2011-04-28 | Henkel Ag & Co. Kgaa | Composition for shaping keratinic fibers |
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| CN114306131A (en) * | 2022-01-27 | 2022-04-12 | 广州百孚润化工有限公司 | Washing composition based on modified corn starch and preparation method thereof |
| CN115381736A (en) * | 2022-09-28 | 2022-11-25 | 广州百孚润化工有限公司 | Eye cream composition and preparation method thereof |
| CN116370320A (en) * | 2023-04-17 | 2023-07-04 | 董业清 | Ecological soft mud film and preparation method thereof |
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