CN117279502A - 用于异种移植的生长激素受体敲除的多转基因猪 - Google Patents

用于异种移植的生长激素受体敲除的多转基因猪 Download PDF

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Publication number
CN117279502A
CN117279502A CN202180091507.0A CN202180091507A CN117279502A CN 117279502 A CN117279502 A CN 117279502A CN 202180091507 A CN202180091507 A CN 202180091507A CN 117279502 A CN117279502 A CN 117279502A
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gene
transgenic
locus
expression
transgenes
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Chinese (zh)
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M·罗斯布拉特
D·阿亚雷斯
W·埃斯通
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Revivicor Inc
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Revivicor Inc
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CN202180091507.0A 2020-11-20 2021-11-19 用于异种移植的生长激素受体敲除的多转基因猪 Pending CN117279502A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063116718P 2020-11-20 2020-11-20
US63/116,718 2020-11-20
PCT/US2021/060165 WO2022109316A1 (en) 2020-11-20 2021-11-19 Multi-transgenic pigs with growth hormone receptor knockout for xenotransplantation

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CN117279502A true CN117279502A (zh) 2023-12-22

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CN202180091507.0A Pending CN117279502A (zh) 2020-11-20 2021-11-19 用于异种移植的生长激素受体敲除的多转基因猪

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US (1) US20220211018A1 (https=)
EP (1) EP4247151A1 (https=)
JP (1) JP2023551404A (https=)
KR (1) KR20230107335A (https=)
CN (1) CN117279502A (https=)
AU (1) AU2021385081A1 (https=)
CA (1) CA3196707A1 (https=)
IL (1) IL302983A (https=)
WO (1) WO2022109316A1 (https=)

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WO2024151682A1 (en) * 2023-01-10 2024-07-18 Kind Biotechnology Inc. Ethical tissues for transplantation
US20240294869A1 (en) * 2023-03-03 2024-09-05 Nugift Medical Llc Pig xenotransplants into humans without chronic immunosuppression
IL325292A (en) * 2023-06-14 2026-02-01 Kind Biotechnology Inc Ethical tissues for transplantation
CN118415139B (zh) * 2023-07-11 2026-01-30 重庆吉棠生物技术研究院有限公司 一种tekt5基因不表达的异种移植供体猪及制备方法
CN117987465B (zh) * 2023-11-03 2024-11-15 云南农业大学 一种十基因编辑异种器官移植供体猪的构建方法

Citations (3)

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CN108473963A (zh) * 2015-09-09 2018-08-31 雷维维科公司 用于异种移植的多重转基因猪
CN108949832A (zh) * 2018-07-13 2018-12-07 中国农业大学 一种用于敲除猪ghr基因的打靶载体及其应用
WO2019185936A2 (en) * 2018-03-29 2019-10-03 Bruno Reichart Methods and compositions for prolonging the survival after orthotopic and heterotopic xenogeneic heart, kidney, lung or liver transplantations

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