CN117209444A - 免疫调节剂的晶体形式 - Google Patents

免疫调节剂的晶体形式 Download PDF

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Publication number
CN117209444A
CN117209444A CN202311171278.0A CN202311171278A CN117209444A CN 117209444 A CN117209444 A CN 117209444A CN 202311171278 A CN202311171278 A CN 202311171278A CN 117209444 A CN117209444 A CN 117209444A
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CN
China
Prior art keywords
formula
compound
cancer
anhydrous crystalline
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202311171278.0A
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English (en)
Chinese (zh)
Inventor
余姝
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curis Inc
Original Assignee
Curis Inc
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Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Publication of CN117209444A publication Critical patent/CN117209444A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202311171278.0A 2017-09-29 2018-09-27 免疫调节剂的晶体形式 Pending CN117209444A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/CN2017/104485 WO2019061324A1 (en) 2017-09-29 2017-09-29 CRYSTALLINE FORMS OF IMMUNOMODULATORS
CNPCT/CN2017/104485 2017-09-29
CN201880063100.5A CN111163772A (zh) 2017-09-29 2018-09-27 免疫调节剂的晶体形式
PCT/US2018/053052 WO2019067678A1 (en) 2017-09-29 2018-09-27 CRYSTALLINE FORMS OF IMMUNOMODULATORS

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880063100.5A Division CN111163772A (zh) 2017-09-29 2018-09-27 免疫调节剂的晶体形式

Publications (1)

Publication Number Publication Date
CN117209444A true CN117209444A (zh) 2023-12-12

Family

ID=65900346

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201880063100.5A Pending CN111163772A (zh) 2017-09-29 2018-09-27 免疫调节剂的晶体形式
CN202311171278.0A Pending CN117209444A (zh) 2017-09-29 2018-09-27 免疫调节剂的晶体形式

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201880063100.5A Pending CN111163772A (zh) 2017-09-29 2018-09-27 免疫调节剂的晶体形式

Country Status (14)

Country Link
US (5) US11040948B2 (enExample)
EP (1) EP3687534A4 (enExample)
JP (2) JP7783688B2 (enExample)
KR (2) KR20200060402A (enExample)
CN (2) CN111163772A (enExample)
AU (2) AU2018341583B2 (enExample)
BR (1) BR112020006137A2 (enExample)
CA (1) CA3076013A1 (enExample)
EA (1) EA202090500A1 (enExample)
IL (2) IL315814A (enExample)
MY (1) MY201378A (enExample)
PH (1) PH12020550133A1 (enExample)
SG (1) SG11202002378XA (enExample)
WO (2) WO2019061324A1 (enExample)

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Also Published As

Publication number Publication date
IL273463A (en) 2020-05-31
AU2018341583A1 (en) 2020-04-02
US20240182433A1 (en) 2024-06-06
AU2018341583B2 (en) 2024-04-04
US20200247766A1 (en) 2020-08-06
US11040948B2 (en) 2021-06-22
KR20240115921A (ko) 2024-07-26
BR112020006137A2 (pt) 2020-10-13
US12252475B2 (en) 2025-03-18
US11643401B2 (en) 2023-05-09
US20210380544A1 (en) 2021-12-09
US11939306B2 (en) 2024-03-26
JP2023134541A (ja) 2023-09-27
EP3687534A4 (en) 2021-06-30
CN111163772A (zh) 2020-05-15
MY201378A (en) 2024-02-21
US20250188045A1 (en) 2025-06-12
KR20200060402A (ko) 2020-05-29
AU2024201938A1 (en) 2024-04-11
EA202090500A1 (ru) 2020-11-03
PH12020550133A1 (en) 2021-02-08
WO2019067678A1 (en) 2019-04-04
EP3687534A1 (en) 2020-08-05
JP2021501127A (ja) 2021-01-14
SG11202002378XA (en) 2020-04-29
WO2019061324A1 (en) 2019-04-04
CA3076013A1 (en) 2019-04-04
US20230167077A1 (en) 2023-06-01
JP7783688B2 (ja) 2025-12-10
IL315814A (en) 2024-11-01

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