CN117158504A - Plant soft sweet for improving respiratory tract immunity and preparation process thereof - Google Patents
Plant soft sweet for improving respiratory tract immunity and preparation process thereof Download PDFInfo
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- CN117158504A CN117158504A CN202310295068.6A CN202310295068A CN117158504A CN 117158504 A CN117158504 A CN 117158504A CN 202310295068 A CN202310295068 A CN 202310295068A CN 117158504 A CN117158504 A CN 117158504A
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a plant soft candy for improving respiratory tract immunity, which can be in the form of gel soft candy, coated soft candy or sandwich soft candy, comprises a composition for improving respiratory tract immunity, adopts herbal immunity components with homology of medicine and food, has no toxic or side effect on the body, can regulate the multiple menstruation of a human body, and comprehensively improves symptoms such as cough, expectoration, hypodynamia, somnolence, mental inadequacy and the like caused by respiratory tract immunity and disorder thereof; can better shade bad flavor and taste in herb, and enable the effective components to directly act on human body through oral mode, and slowly release in chewing process, thereby achieving the effect of improving respiratory tract immunity. The invention also discloses a preparation process of the plant soft sweet for improving the respiratory tract immunity, wherein the mixing temperature is between 70 and 80 ℃, is lower than the extraction temperature of the composition for improving the respiratory tract immunity, can avoid the destruction of heat-sensitive components to a certain extent, and ensures the stability of the functional components in the processing process.
Description
Technical Field
The invention relates to a plant soft sweet for improving respiratory tract immunity and a preparation process thereof.
Background
The current major cause of respiratory tract immune disorders (either hyperimmune or hyperimmune) is a deterioration of the physiological environment. The deterioration of the external environment leads to the enhancement of respiratory tract sensitivity, so that various respiratory tract diseases such as tracheitis, bronchitis, pneumonia, pharyngitis, tonsillitis, upper respiratory tract infection, anaphylaxis and the like are easily obtained, and the long-term repeated attack of the diseases finally leads to the pulmonary immunity disorder.
In order to relieve the series of symptoms, some people choose to purchase heat-clearing tea drinks which are promoted in the market, or eat medicines for clearing lung-heat and relieving cough, etc., but the symptomatic effect is uneven, and toxic and side effects after the medicine is ingested need to be eliminated by relying on livers, which is a clear increase of physical burden. The tablet has the advantages of small volume, stable quality, easy production, easy carrying, convenient eating and the like, and can be timely taken when people feel uncomfortable, thereby relieving symptoms. At present, buccal tablet products for improving the immunity of the respiratory tract are not seen in the market.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, and provides a plant soft candy for improving respiratory tract immunity, which adopts herbal immunity components with homology of medicine and food, has no toxic or side effect on a human body, can regulate multiple menstruation of the human body, and comprehensively improves symptoms such as cough, expectoration, hypodynamia, somnolence, mental inadequacy and the like caused by respiratory tract immunity and disorder thereof; can better shade bad flavor and taste in herbaceous, and let the active ingredient directly act on the human body through oral mode, slowly release in the chewing process, accomplish the dosing in the pleasure of edible soft sweets.
The invention also aims to provide a preparation process of the plant soft sweet for improving the respiratory tract immunity, wherein the mixing temperature is between 70 and 80 ℃, is lower than the extraction temperature of the composition for improving the respiratory tract immunity, can avoid damaging heat-sensitive components to a certain extent, and ensures the stability of the functional components in the processing process.
The technical scheme for achieving the purpose is as follows: the plant soft sweet for improving the respiratory tract immunity is in the form of gel soft sweet, and comprises the following components in parts by weight: 1 to 10 parts of composition for improving respiratory tract immunity, 10 to 14 parts of colloid, 30 to 50 parts of sugar substitute and 0 to 1.2 parts of sour regulator;
the composition for improving respiratory tract immunity is prepared from the following components in parts by weight: 50-150 parts of honeysuckle, 20-80 parts of dried orange peel, 10-50 parts of phyllanthus emblica, 10-50 parts of liquorice, 10-30 parts of Chinese yam, 10-30 parts of peppermint, 10-30 parts of ampelopsis grossedentata leaf, 5-15 parts of perilla seed, 5-15 parts of fructus momordicae, 1-5 parts of Yunnan yellow ginger, 12-48 parts of turmeric and 20-80 parts of black pepper.
The plant soft sweet for improving respiratory tract immunity, wherein: the colloid adopts at least one of gelatin, pectin, locust bean gum, guar gum, gellan gum and konjac gum;
the sugar substitute adopts at least one of xylitol, maltitol solution, maltitol powder, resistant dextrin and erythritol;
the sour regulator adopts citric acid and/or malic acid.
The plant soft sweet for improving the respiratory tract immunity is coated soft sweet, and comprises the following components in parts by weight: 1 to 10 parts of composition for improving respiratory tract immunity, 10 to 14 parts of colloid, 30 to 50 parts of sugar substitute, 0 to 1.2 parts of sour regulator and 0 to 2 parts of buffer salt; the coating of the coated soft sweets adopts collagen casing;
the composition for improving respiratory tract immunity is prepared from the following components in parts by weight: 50-150 parts of honeysuckle, 20-80 parts of dried orange peel, 10-50 parts of phyllanthus emblica, 10-50 parts of liquorice, 10-30 parts of Chinese yam, 10-30 parts of peppermint, 10-30 parts of ampelopsis grossedentata leaf, 5-15 parts of perilla seed, 5-15 parts of fructus momordicae, 1-5 parts of Yunnan yellow ginger, 12-48 parts of turmeric and 20-80 parts of black pepper.
The plant soft sweet for improving respiratory tract immunity, wherein: the colloid adopts at least one of gelatin, pectin, locust bean gum, guar gum, gellan gum and konjac gum;
the sugar substitute adopts at least one of xylitol, maltitol solution, maltitol powder, resistant dextrin and erythritol;
the sour regulator adopts citric acid and/or malic acid;
the buffer salt adopts at least one of calcium chloride, calcium lactate, tricalcium phosphate, calcium hydrophosphate, dipotassium hydrogen phosphate, potassium citrate, sodium citrate, potassium sorbate, magnesium oxide, magnesium sulfate and magnesium gluconate.
The plant soft sweet for improving the respiratory tract immunity is in a dosage form of a sandwich soft sweet, and consists of an inner layer core material and an outer layer skin material, wherein the inner layer core material consists of 1-10 parts by weight of a functional composition for improving the respiratory tract immunity, 30-50 parts by weight of sugar substitutes and 0-1.2 parts by weight of a sour regulator; the outer leather comprises the following components in parts by weight: 10-14 parts of colloid, 30-50 parts of sugar substitute and 10-50 parts of concentrated apple juice; the mass ratio of the inner layer core material to the outer layer skin material is 1 (4-6);
the composition for improving respiratory tract immunity is prepared from the following components in parts by weight: 50-150 parts of honeysuckle, 20-80 parts of dried orange peel, 10-50 parts of phyllanthus emblica, 10-50 parts of liquorice, 10-30 parts of Chinese yam, 10-30 parts of peppermint, 10-30 parts of ampelopsis grossedentata leaf, 5-15 parts of perilla seed, 5-15 parts of fructus momordicae, 1-5 parts of Yunnan yellow ginger, 12-48 parts of turmeric and 20-80 parts of black pepper.
The plant soft sweet for improving the respiratory tract immunity is characterized in that the colloid adopts at least one of gelatin, pectin, locust bean gum, guar gum, gellan gum and konjac gum;
the sugar substitute adopts at least one of xylitol, maltitol solution, maltitol powder, resistant dextrin and erythritol;
the sour regulator adopts citric acid and/or malic acid.
The plant soft sweet for improving the respiratory tract immunity is prepared by adopting an aqueous extract extraction process, and comprises the following specific steps of: weighing crude drug decoction pieces of each component according to the formula of the composition for improving respiratory tract immunity, crushing or sieving the crude drug decoction pieces with a standard sieve of 3-5 meshes after crushing, adding 10-15 times of water by volume after uniformly mixing, heating and refluxing for 1.5-3 hours at 90-100 ℃, filtering the obtained extract by using a sieve of 150-300 meshes, repeatedly heating and extracting for 1-3 times and filtering, merging all filtrate, vacuum concentrating to 1/5-1/10 of the volume of the original filtrate under the conditions of 50-70 ℃ and vacuum degree of 70-100 mbar, and freeze-drying the concentrated solution to obtain the composition for improving respiratory tract immunity.
The plant soft sweet for improving the respiratory tract immunity is prepared by adopting an ultrafine powder process, and comprises the following specific steps of: weighing crude drug decoction pieces of each component according to the formula of the composition for improving respiratory tract immunity, placing the crude drug decoction pieces into a traditional Chinese medicine powder making machine for preliminary crushing, passing through a No. 4 sieve or a No. 5 sieve, and then adopting an ultrafine grinder for crushing to obtain the composition for improving respiratory tract immunity, wherein the rotating speed of the ultrafine grinder is 300-400 rpm, the crushing time is 20-40 min, the ball-to-material ratio is (5-20): 1, and the ball-to-ball ratio is (1-6).
The plant soft sweet for improving the respiratory tract immunity is prepared by an aqueous extract extraction process, wherein the rest components are prepared by an ultrafine powder process, and the specific steps are as follows:
A. weighing crude drug decoction pieces of each component according to the formula of the composition for improving respiratory tract immunity;
B. placing crude drug decoction pieces of a part of the components in a traditional Chinese medicine powder grinding machine for preliminary grinding, passing through a No. 4 sieve or a No. 5 sieve, and then grinding by an ultrafine grinder to obtain ultrafine powder for later use; the rotational speed of the superfine pulverizer is 300-400 rpm, the pulverizing time is 20-40 min, the ball-to-material ratio (5-20): 1, and the ratio of the big ball to the small ball is 1 (1-6);
C. the crude drug decoction pieces of the rest components are not required to be smashed or smashed and then pass through a standard sieve with 3 meshes to 5 meshes, water with 10 to 15 times of volume is added after the mixture is evenly mixed, heating reflux is carried out for 1.5 to 3 hours at the temperature of 90 to 100 ℃, the obtained extract is filtered by a sieve with 150 meshes to 300 meshes, heating extraction is repeated for 1 to 3 times and filtering, all the filtrates are combined, vacuum concentration is carried out to 1/5 to 1/10 of the volume of the original filtrate under the conditions of the temperature of 50 to 70 ℃ and the vacuum degree of 70 to 100mbar, and then the concentrated liquid is freeze-dried to obtain freeze-dried powder of the water extract for standby;
D. and then mixing the superfine powder obtained in the step B and the water extract freeze-dried powder obtained in the step C, and then placing the mixture into a superfine pulverizer to pulverize the mixture to obtain the composition for improving the respiratory tract immunity, wherein the rotating speed of the superfine pulverizer is 300-400 rpm, the pulverizing time is 20-40 min, the ball-to-material ratio is (5-20): 1, and the proportion of the big balls to the small balls is (1-6).
The invention also provides a preparation process of the plant soft candy for improving respiratory tract immunity, which comprises the following steps:
s1, colloid preparation: weighing 10-14 parts of colloid, adding 17-20 parts of water, swelling for 1-2 hours, and heating to 70-80 ℃ to melt for later use;
s2, sugar boiling: weighing 30-50 parts of substituted sugar, and boiling to 100-120 ℃ to form sugar liquid for later use;
s3, blending: and (3) cooling the sugar solution in the step (S2) to 80-90 ℃, adding the colloid prepared in the step (S1) into the sugar solution, uniformly mixing, adding the composition for improving the respiratory tract immunity and the sour regulator, uniformly stirring, and then sequentially carrying out injection molding, cooling and demolding to obtain the plant soft candy with the gel soft candy dosage form for improving the respiratory tract immunity.
A preparation process of a plant soft candy for improving respiratory tract immunity of a coated soft candy dosage form comprises the following steps:
s1, colloid preparation: weighing 10-14 parts of colloid, adding 17-20 parts of water, swelling for 1-2 hours, and heating to 70-80 ℃ to melt for later use;
s2, sugar boiling: weighing 30-50 parts of substituted sugar, and boiling to 100-120 ℃ to form sugar liquid for later use;
s3, blending: cooling the sugar solution in the step S2 to 80-90 ℃, adding the colloid prepared in the step S1 into the sugar solution, uniformly mixing, then adding the composition for improving the respiratory tract immunity, the sour regulator and the buffer salt, and uniformly stirring to obtain a first mixture A;
s4, filtering: discharging the first mixture into filtering equipment, and filtering through a 40-80 mesh sieve to obtain a second mixture;
s5, filling: filling the second mixture into collagen casing, cooling and molding to obtain crude soft sweet;
s6, shearing: transferring the shaped crude soft sweet into a kinking machine and a shearing machine, and kinking and shearing to obtain soft sweet particles;
s7, drying: and (3) placing the soft candy particles into a drying room for drying for 20-60 hours to obtain the plant soft candy coated with the soft candy formulation and improving respiratory tract immunity.
A preparation process of a plant soft candy with a sandwich soft candy formulation for improving respiratory tract immunity comprises the following steps:
s1, preparing an inner layer core material: taking a part of sugar substitute, boiling to 100-120 ℃ to form sugar liquid, then cooling to 80-90 ℃, adding 1-10 parts of functional composition for improving respiratory tract immunity and 0-1.2 parts of sour regulator into the mixture, and uniformly mixing to prepare an inner core material;
s2, preparing an outer leather material:
s21, colloid preparation: weighing 10-14 parts of colloid, adding 17-20 parts of water, swelling for 1-2 hours, and heating to 70-80 ℃ to melt for later use;
s22, sugar boiling: taking the rest sugar substitute, and boiling to 100-120 ℃ to form sugar liquor for standby;
s23, a blending step: cooling the sugar solution in the step S22 to 80-90 ℃, adding the colloid prepared in the step S21 into the sugar solution, uniformly mixing, then adding concentrated apple juice, and uniformly stirring to obtain an outer layer leather mixture;
s3, casting molding: and (3) conveying the outer layer skin material mixture and the inner layer core material into a storage tank of a sandwich soft candy pouring molding machine, preserving heat at 70-80 ℃, casting and molding, cooling and solidifying, and demolding to obtain the plant soft candy with the sandwich soft candy dosage form for improving respiratory tract immunity.
The plant soft sweet for improving the respiratory tract immunity and the preparation process thereof have the beneficial effects that:
(1) The raw materials of the composition for improving respiratory tract immunity adopt herbal immunity components with homology of medicine and food, are easy to obtain, safe and effective, and have no toxic or side effect on the body; the formula is comprehensive, reasonable and scientific;
(2) Comprehensively improves symptoms such as cough, expectoration, hypodynamia, sleepiness, mental inadequacy, gastrointestinal discomfort and the like caused by respiratory tract immunity and disorder thereof, has positive effects on improving and relieving respiratory tract infection symptoms, and does not cause other damages to the body;
(3) The soft candy is a new formulation for improving respiratory tract immunity, can better shield bad flavor and taste in herbs, and enables active ingredients to directly act on a human body in an oral mode, and is slowly released in the chewing process, and drug administration is completed in pleasure of eating the soft candy; meanwhile, the coating soft sweet forms bionic peel by virtue of a casing, so that the edible pleasure of the soft sweet is improved, and the layering sense of the soft sweet is enriched; the sandwich soft candy increases the expectations of consumers in eating, increases the flavor level of the soft candy and enriches the eating experience;
(4) The mixing temperature designed in the soft sweet preparation process is between 70 and 80 ℃ which is lower than the extraction temperature of the composition for improving the respiratory tract immunity, so that the destruction of heat-sensitive components can be avoided to a certain extent, and the stability of active ingredients in the processing process is ensured; the gel soft sweet can avoid drying through the optimization of the formula and the process, and can shorten the production period and reduce the production cost; the coated soft sweets are easy to generate water-out phenomenon, and the colloid with better water-retaining property is selected to reduce the water-out phenomenon. The sandwich soft sweet core material has reasonable design, and the sandwich soft sweet can be well positioned in the middle by matching with a casting machine, so that the quality stability of the soft sweet is ensured;
(5) The sweetener used in the formula of the soft candy is sugar substitute, has low heat compared with sucrose and fructose syrup, has better supporting effect on the structure of the soft candy, realizes the sugar reduction of the formula, and reduces the eating burden; the soft sweet formula has no essence and spice, presents the natural fragrance of herbaceous plants, has no bitter taste, has proper sweet feel, and can more easily meet the daily dosage requirement.
Drawings
FIG. 1 is a flow chart of a process for preparing a plant gum for improving respiratory tract immunity in a gel gum dosage form;
FIG. 2 is a flow chart of a process for preparing a coated soft candy dosage form of a plant soft candy for improving respiratory tract immunity;
fig. 3 is a flow chart of a process for preparing a plant gum for improving respiratory tract immunity in a sandwich gum dosage form.
Detailed Description
In order to enable those skilled in the art to better understand the technical scheme of the present invention, the following detailed description is provided with reference to the accompanying drawings:
the composition for improving respiratory tract immunity is prepared from the following components in parts by weight: 100 parts of honeysuckle, 50 parts of dried orange peel, 30 parts of phyllanthus emblica, 30 parts of liquorice, 20 parts of Chinese yam, 20 parts of mint, 20 parts of ampelopsis grossedentata leaves, 10 parts of perilla seed, 10 parts of fructus momordicae, 3 parts of yellow ginger in Yunnan province, 30 parts of turmeric and 50 parts of black pepper.
The components in the composition for improving the respiratory tract immunity adopt crude drug decoction piece water extracts or crude drug decoction piece superfine powder, or part of the components in the composition for improving the respiratory tract immunity adopt crude drug decoction piece superfine powder, and the rest components adopt crude drug decoction piece water extracts.
The composition for improving respiratory tract immunity is prepared by adopting an aqueous extract extraction process, and comprises the following specific steps: weighing crude drug decoction pieces (raw materials) of each component according to a formula of the composition for improving respiratory immunity, namely 100 parts of honeysuckle, 50 parts of dried orange peel, 30 parts of phyllanthus emblica, 30 parts of liquorice, 20 parts of Chinese yam, 20 parts of peppermint, 20 parts of ampelopsis grossedentata leaves, 10 parts of perilla seeds, 10 parts of fructus momordicae, 3 parts of small yellow ginger in Yunnan, 30 parts of turmeric and 50 parts of black pepper; mashing phyllanthus emblica, perilla seeds, fructus momordicae and black pepper, sieving with a 4-mesh standard sieve, uniformly mixing, mashing and adding water with 10 times of the volume of other components which are not mashed, heating and refluxing for 3 hours at 100 ℃, filtering an extracting solution by using a 200-mesh sieve, heating and extracting for 1-3 times, filtering, combining all filtrate, vacuum concentrating to 1/10 of the volume of the original filtrate under the conditions of the temperature of 60 ℃ and the vacuum degree of 100mbar, and freeze-drying the concentrated solution to obtain the composition for improving the respiratory tract immunity.
The composition for improving respiratory tract immunity is prepared by adopting an ultrafine powder process, and comprises the following specific steps: weighing crude drug decoction pieces (raw materials) of each component according to a formula of the composition for improving respiratory tract immunity, namely 100 parts of honeysuckle, 50 parts of dried orange peel, 30 parts of phyllanthus emblica, 30 parts of liquorice, 20 parts of Chinese yam, 20 parts of mint, 20 parts of ampelopsis grossedentata leaves, 10 parts of perilla seeds, 10 parts of fructus momordicae, 3 parts of yellow ginger in Yunnan province, 30 parts of turmeric and 50 parts of black pepper, placing the crude drug decoction pieces of all components into a traditional Chinese medicine powdering machine for preliminary grinding, sieving with a No. 5 sieve (180 mu m +/-7.6 mu m,80 meshes), and grinding by using an ultrafine grinder to obtain the composition for improving respiratory tract immunity, wherein the parameters of the ultrafine grinder are that the rotating speed is 400rpm, the ball-to-material ratio is 10:1, and the ball size (7 mm:3 mm) =1:4 for standby.
The composition for improving respiratory tract immunity is prepared from a part of components by an aqueous extract extraction process, and the rest of components by an ultrafine powder process, and comprises the following specific steps:
A. weighing crude drug decoction pieces of each component according to a formula of the composition for improving respiratory immunity, namely 100 parts of honeysuckle, 50 parts of dried orange peel, 30 parts of phyllanthus emblica, 30 parts of liquorice, 20 parts of Chinese yam, 20 parts of peppermint, 20 parts of ampelopsis grossedentata leaves, 10 parts of perilla seed, 10 parts of fructus momordicae, 3 parts of yellow ginger in Yunnan province, 30 parts of turmeric and 50 parts of black pepper;
B. placing 30 parts of phyllanthus emblica, 20 parts of Chinese yam, 10 parts of perilla seed, 10 parts of momordica grosvenori and 50 parts of black pepper into a traditional Chinese medicine powder grinding machine for preliminary grinding, sieving with a No. 5 sieve (180 mu m plus or minus 7.6 mu m,80 meshes), grinding by using an ultrafine grinder, wherein the parameters of the ultrafine grinder are that the rotating speed is 400rpm, the time is 30min, the ball-to-material ratio is 10:1, and the size and the ball (7 mm:3 mm) =1:4, so as to prepare ultrafine powder for standby;
C. mixing 100 parts of honeysuckle, 50 parts of dried orange peel, 30 parts of liquorice, 20 parts of mint, 20 parts of ampelopsis grossedentata leaves, 3 parts of yellow ginger in Yunnan and 30 parts of turmeric, adding 10 times of water, heating and refluxing for 3 hours at 100 ℃, filtering an extracting solution by using a 200-mesh sieve, repeatedly heating and extracting for 3 times, filtering, combining all the filtrates, concentrating in vacuum to 1/10 of the volume of the original filtrate under the conditions of the temperature of 60 ℃ and the vacuum degree of 100mbar, and concentrating parameters: the temperature is 60 ℃, the vacuum degree is 100mbar, then the concentrated solution is subjected to liquid cooling freeze drying to obtain water extract freeze-dried powder, and coarse powder of the water extract freeze-dried powder is screened by a granulator for standby;
D. and then, mixing 1.2 parts of the superfine powder obtained in the step B and 0.63 part of the water extract freeze-dried powder obtained in the step C, and then, putting the mixture into a superfine pulverizer to pulverize the mixture to obtain the composition for improving respiratory tract immunity, wherein the rotating speed of the superfine pulverizer is 300rpm, the time is 5min, the ball-to-material ratio is 5:1, the size balls (7 mm:3 mm) =1:4, 1.83 parts of the composition for improving respiratory tract immunity is mixed, and the minimum mass ratio of the superfine powder to the water extract freeze-dried powder is 1.2:0.63, 1.83 parts of the respiratory tract immunity-improving composition obtained according to the step being the minimum part unit of the respiratory tract immunity-improving composition.
Table 1: formulation table of plant soft sweets for improving respiratory tract immunity:
in table 1, gelatin, pectin and gellan gum are all colloids, and in actual use, other colloids can be used as required to replace the gelatin, such as locust bean gum, guar gum, konjac gum and the like; the maltitol solution and the maltitol powder are sugar substitutes, and in actual use, other sugar substitutes can be adopted according to the need, such as xylitol, resistant dextrin, erythritol and the like; the concentrated apple juice is a flavor regulator of the outer layer leather of the sandwich soft sweet, and in actual use, other flavor regulators can be adopted to replace the concentrated apple juice according to the needs. Citric acid and malic acid are sour taste modifiers. The calcium chloride is a buffer salt, and the coated soft candy needs to be replaced by other buffer salts according to the needs in actual use, such as calcium lactate, tricalcium phosphate, calcium hydrogen phosphate, dipotassium hydrogen phosphate, potassium citrate, sodium citrate, potassium sorbate, magnesium oxide, magnesium sulfate, magnesium gluconate and the like.
Referring to fig. 1, a plant soft candy for improving respiratory tract immunity of a gel soft candy formulation was prepared according to the formulation of example 1-example 3 in table 1, and the preparation process comprises the following steps:
s1, colloid preparation: weighing 12.5 parts of gelatin, adding 17 parts of water, swelling for 1 hour, and heating to 75 ℃ to melt for later use;
s2, sugar boiling: weighing 25 parts of maltitol solution and 25 parts of maltitol powder, and boiling to 115 ℃ to form sugar solution for later use;
s3, blending: and (3) cooling the sugar solution in the step (S2) to 80 ℃, adding the colloid prepared in the step (S1) into the sugar solution, uniformly mixing, then adding the composition for improving the respiratory tract immunity and the sour regulator, uniformly stirring, and then sequentially carrying out injection molding, cooling and demolding to obtain the plant soft candy with the gel soft candy dosage form for improving the respiratory tract immunity.
Referring to fig. 2, a coated soft candy formulation with improved respiratory tract immunity was prepared according to the formulation of example 4-example 6 in table 1, the preparation process comprising the following steps:
s1, colloid preparation: weighing 12.5 parts of colloid (7 parts of pectin and 5.5 parts of gellan gum), adding 17 parts of water, swelling for 1 hour, and heating to 75 ℃ to melt for later use;
s2, sugar boiling: weighing 25 parts of maltitol solution and 25 parts of maltitol powder, and boiling to 115 ℃ to form sugar solution for later use;
s3, blending: adding the colloid prepared in the step S1 into the sugar solution when the sugar solution in the step S2 is cooled to 80 ℃, uniformly mixing, then adding the composition for improving the respiratory tract immunity and the sour regulator (0.5 part of citric acid and 0.5 part of malic acid), and uniformly stirring to obtain a first mixture A;
s4, filtering: discharging the first mixture into filtering equipment, and filtering through a 40-80 mesh sieve to obtain a second mixture;
s5, filling: filling the second mixture into collagen casing, cooling and molding to obtain crude soft sweet;
s6, shearing: transferring the shaped crude soft sweet into a kinking machine and a shearing machine, and kinking and shearing to obtain soft sweet particles;
s7, drying: and (3) placing the soft candy particles into a drying room for drying for 20-60 hours to obtain the plant soft candy coated with the soft candy formulation and improving respiratory tract immunity.
Referring to fig. 3, a plant soft candy for improving respiratory tract immunity in a sandwich soft candy dosage form was prepared according to the formulation of example 7-example 9 in table 1, the preparation process comprising the following steps:
s1, preparing an inner layer core material: decocting a part of sugar substitute to 115 ℃ to form sugar solution, and then cooling to 80 ℃, adding 6 parts of functional composition for improving respiratory tract immunity and 0.5 part of sour regulator into the sugar solution, and uniformly mixing to prepare an inner core material;
s2, preparing an outer leather material:
s21, colloid preparation: weighing 12.5 parts of colloid (7 parts of gelatin and 5.5 parts of pectin), adding 17 parts of water, swelling for 1 hour, and heating to 75 ℃ to melt for later use;
s22, sugar boiling: decocting the rest sugar substitute to 115 ℃ to form sugar solution for standby;
s23, a blending step: cooling the sugar solution in the step S22 to 80 ℃, adding the colloid prepared in the step S21 into the sugar solution, uniformly mixing, then adding concentrated apple juice, and uniformly stirring to obtain an outer layer leather mixture;
s3, casting molding: and (3) conveying the outer layer skin material mixture and the inner layer core material into a storage tank of a sandwich soft sweet pouring molding machine, preserving heat at 70-80 ℃, casting and molding, cooling and solidifying, and demolding to obtain the sandwich plant soft sweet for improving respiratory tract immunity.
Efficacy validation experiment of the composition for improving respiratory tract immunity:
through the test of 10 persons in 4 days, the medicine has the tendency of improving 10 symptoms of cough, hypodynamia, mental retardation, slow brain reaction, asthma or shortness of breath, somnolence, taste/smell decline, expectoration, nasal obstruction/running nose and low emotion, and particularly has obvious improvement in the aspects of symptoms of cough, expectoration, hypodynamia, somnolence, mental retardation and the like.
The specific test process of human body test clothes is as follows:
the human body test of 10 persons with respiratory tract discomfort after new crown infection is carried out by the test personnel of the intervention group, the composition for improving respiratory tract immunity is continuously tested for 4 days, each person carries out scoring according to symptom improvement condition every day, and then statistical analysis is carried out according to the scoring, so as to evaluate the effectiveness of the product formula.
Meanwhile, a control group is set, 10 persons with respiratory tract discomfort after new crown infection are selected from the control group, the composition for improving respiratory tract immunity is not taken, scoring is carried out according to the symptoms of each person every day, and then statistical analysis is carried out according to the scoring.
1. Product morphology: the composition for improving respiratory tract immunity in the form of a teabag (3.8 g/bag) is prepared from the following components in parts by weight: 100 parts of honeysuckle, 50 parts of dried orange peel, 30 parts of phyllanthus emblica, 30 parts of liquorice, 20 parts of Chinese yam, 20 parts of mint, 20 parts of ampelopsis grossedentata leaves, 10 parts of perilla seed, 10 parts of fructus momordicae, 3 parts of yellow ginger in Yunnan province, 30 parts of turmeric and 50 parts of black pepper.
2. The administration method comprises the following steps: each person takes the medicine 2 times a day, 1 bag each time, and the medicine is taken after being brewed with boiled water for 5 minutes.
3. The panelist of the intervention group: 10 patients with respiratory tract discomfort after new crown infection;
4. personnel of the control group: 10 patients with respiratory tract discomfort after new crown infection;
5. scoring indexes: 16 indices-cough, asthma or shortness of breath, expectoration, debilitation, somnolence, stuffy nose/runny nose, mental retardation, insomnia, gastrointestinal discomfort, taste and smell deterioration, chest pain caused by cough, low emotion, occasional dizziness, arthralgia, occasional palpitation, and slow brain bag reaction-each index was set for 1-5 minutes, and a smaller score indicates a more alleviation of symptoms.
6. The statistics of the improvement of symptoms caused by respiratory tract immunity disorder in the intervention group are shown in table 2:
table 2:
in table 2, the values are expressed as mean±standard deviation (mean±sem); * Represent vs.0Days (compare to day 0 data), P <0.05; * Represent vs.0days (compare to day 0 data), P <0.01; * vs.0Days (compare to day 0 data), P <0.001.
7. The statistics of the symptoms caused by the airway immunity disorder of the control group are shown in Table 3:
table 3:
in table 3, the values are expressed as mean±standard deviation (mean±sem); # represents vs.1Days (compared to day 1), P <0.05.
Compared with the data in the tables 2 and 3, the composition for improving respiratory tract immunity of the present invention has a tendency to improve 10 symptoms such as cough, hypodynamia, mental retardation, slowed down of mental reaction, asthma or shortness of breath, sleepiness, taste/smell deterioration, expectoration, nasal obstruction/running nose and depressed mood, and has a remarkable improving effect especially on the symptoms such as cough, expectoration, hypodynamia, sleepiness, mental retardation, etc.
The plant soft sweet for improving the respiratory tract immunity is prepared from medicinal and edible herbs or extracts thereof which are homologous and have the effect of improving the respiratory tract immunity, and the honeysuckle, the dried orange peel, the liquorice and the phyllanthus emblica which are in the composition are used for achieving the effects of clearing heat and detoxicating, eliminating dampness and resolving phlegm, tonifying spleen and nourishing stomach, promoting the production of body fluid and quenching thirst, and are matched with the ampelopsis grossedentata leaves, the perilla seeds, the mint, the Yunnan yellow jacket, the Chinese yam and the momordica grosvenori which are used for promoting diuresis, resolving phlegm and relieving cough, eliminating phlegm and relieving sore throat, tonifying lung qi and the like. In addition, turmeric and black pepper which have auxiliary improving effect on symptoms caused by respiratory tract immunity disorder are added into the composition, so that the effect of improving respiratory tract immunity is comprehensively achieved.
The plant soft sweet for improving the respiratory tract immunity is a novel dosage form for improving the respiratory tract immunity. Can better shade bad flavor and taste in herb, and enable the effective components to directly act on human body through oral mode, and slowly release in chewing process, thereby achieving the effect of improving respiratory tract immunity. Meanwhile, the coating soft sweet forms bionic peel by virtue of the casing, so that the edible pleasure of the soft sweet is improved, and the layering sense of the soft sweet is enriched. The sandwich soft candy increases the expectations of consumers in eating, increases the flavor level of the soft candy and enriches the eating experience; the mixing temperature designed in the soft sweet preparation process is between 70 and 80 ℃ which is lower than the extraction temperature of the composition for improving respiratory tract immunity, so that the destruction of heat-sensitive components can be avoided to a certain extent, and the stability of active ingredients in the processing process is ensured. The gel soft sweet can avoid drying after the formula and the process are optimized, and can shorten the production period and reduce the production cost. The coated soft sweets are easy to generate water-out phenomenon, and the colloid with better water-retaining property is selected to reduce the water-out phenomenon. The sandwich soft sweet core material has reasonable design, and the sandwich soft sweet can be well positioned in the middle by matching with a casting machine, so that the quality stability of the soft sweet is ensured; the sweetener used in the formula of the soft candy is sugar substitute, has low heat compared with sucrose and fructose syrup, has better supporting effect on the structure of the soft candy, realizes the sugar reduction of the formula, and reduces the eating burden; the soft sweet formula has no essence and spice, presents the natural fragrance of herbaceous plants, has no bitter taste, has proper sweet feel, and can more easily meet the daily dosage requirement.
In conclusion, the plant soft sweet for improving the respiratory tract immunity and the preparation process thereof adopt herbal immunity components with homology of medicine and food, have no toxic or side effect on the body, and can comprehensively improve symptoms such as cough, expectoration, hypodynamia, somnolence, mental inadequacy and the like caused by the respiratory tract immunity and the disorder of the respiratory tract immunity through conditioning of the human body. The mixing temperature in the preparation process is between 70 and 80 ℃ which is lower than the extraction temperature of the composition for improving respiratory tract immunity, so that the damage to heat-sensitive components can be avoided to a certain extent, and the stability of the functional components in the processing process is ensured.
It will be appreciated by persons skilled in the art that the above embodiments are provided for illustration only and not for limitation of the invention, and that variations and modifications of the above described embodiments are intended to fall within the scope of the claims of the invention as long as they fall within the true spirit of the invention.
Claims (11)
1. The plant soft candy is characterized by comprising the following components in parts by weight: 1 to 10 parts of composition for improving respiratory tract immunity, 10 to 14 parts of colloid, 30 to 50 parts of sugar substitute and 0 to 1.2 parts of sour regulator;
the composition for improving respiratory tract immunity is prepared from the following components in parts by weight: 50-150 parts of honeysuckle, 20-80 parts of dried orange peel, 10-50 parts of phyllanthus emblica, 10-50 parts of liquorice, 10-30 parts of Chinese yam, 10-30 parts of peppermint, 10-30 parts of ampelopsis grossedentata leaf, 5-15 parts of perilla seed, 5-15 parts of fructus momordicae, 1-5 parts of Yunnan yellow ginger, 12-48 parts of turmeric and 20-80 parts of black pepper.
2. The plant soft candy is characterized by comprising the following components in parts by weight: 1 to 10 parts of composition for improving respiratory tract immunity, 10 to 14 parts of colloid, 30 to 50 parts of sugar substitute, 0 to 1.2 parts of sour regulator and 0 to 2 parts of buffer salt, and the coating of the coated soft candy adopts collagen casing.
The composition for improving respiratory tract immunity is prepared from the following components in parts by weight: 50-150 parts of honeysuckle, 20-80 parts of dried orange peel, 10-50 parts of phyllanthus emblica, 10-50 parts of liquorice, 10-30 parts of Chinese yam, 10-30 parts of peppermint, 10-30 parts of ampelopsis grossedentata leaf, 5-15 parts of perilla seed, 5-15 parts of fructus momordicae, 1-5 parts of Yunnan yellow ginger, 12-48 parts of turmeric and 20-80 parts of black pepper.
3. The plant soft sweet is characterized in that the plant soft sweet is in a sandwich soft sweet form and consists of an inner layer core material and an outer layer skin material, wherein the inner layer core material consists of 1-10 parts by weight of a functional composition for improving respiratory tract immunity, 30-50 parts by weight of sugar substitutes and 0-1.2 parts by weight of a sour regulator; the outer leather comprises the following components in parts by weight: 10-14 parts of colloid, 30-50 parts of sugar substitute and 10-50 parts of concentrated apple juice; the mass ratio of the inner layer core material to the outer layer skin material is 1 (4-6);
the composition for improving respiratory tract immunity is prepared from the following components in parts by weight: 50-150 parts of honeysuckle, 20-80 parts of dried orange peel, 10-50 parts of phyllanthus emblica, 10-50 parts of liquorice, 10-30 parts of Chinese yam, 10-30 parts of peppermint, 10-30 parts of ampelopsis grossedentata leaf, 5-15 parts of perilla seed, 5-15 parts of fructus momordicae, 1-5 parts of Yunnan yellow ginger, 12-48 parts of turmeric and 20-80 parts of black pepper.
4. A plant soft candy for improving immunity to the respiratory tract as claimed in any one of claims 1 to 3, wherein said colloid is at least one of gelatin, pectin, locust bean gum, guar gum, gellan gum and konjac gum;
the sugar substitute adopts at least one of xylitol, maltitol solution, maltitol powder, resistant dextrin and erythritol;
the sour regulator adopts citric acid and/or malic acid.
5. A plant soft candy for improving respiratory tract immunity as in claim 2 wherein the buffer salt is at least one of calcium chloride, calcium lactate, tricalcium phosphate, calcium hydrogen phosphate, dipotassium hydrogen phosphate, potassium citrate, sodium citrate, potassium sorbate, magnesium oxide, magnesium sulfate and magnesium gluconate.
6. A plant soft candy for improving respiratory tract immunity as claimed in any one of claims 1 to 3, wherein the composition for improving respiratory tract immunity is prepared by an aqueous extract extraction process, and comprises the following specific steps: weighing crude drug decoction pieces of each component according to the formula of the composition for improving respiratory tract immunity, crushing or sieving the crude drug decoction pieces with a standard sieve of 3-5 meshes after crushing, adding 10-15 times of water by volume after uniformly mixing, heating and refluxing for 1.5-3 hours at 90-100 ℃, filtering the obtained extract by using a sieve of 150-300 meshes, repeatedly heating and extracting for 1-3 times and filtering, merging all filtrate, vacuum concentrating to 1/5-1/10 of the volume of the original filtrate under the conditions of 50-70 ℃ and vacuum degree of 70-100 mbar, and freeze-drying the concentrated solution to obtain the composition for improving respiratory tract immunity.
7. A plant soft candy for improving respiratory tract immunity according to any one of claims 1 to 3, wherein the composition for improving respiratory tract immunity is prepared by an ultra-fine powder process, and comprises the following specific steps: weighing crude drug decoction pieces of each component according to the formula of the composition for improving respiratory tract immunity, placing the crude drug decoction pieces into a traditional Chinese medicine powder making machine for preliminary crushing, passing through a No. 4 sieve or a No. 5 sieve, and then adopting an ultrafine grinder for crushing to obtain the composition for improving respiratory tract immunity, wherein the rotating speed of the ultrafine grinder is 300-400 rpm, the crushing time is 20-40 min, the ball-to-material ratio is (5-20): 1, and the ball-to-ball ratio is (1-6).
8. A plant soft candy for improving respiratory tract immunity as claimed in any one of claims 1 to 3, wherein a part of components in the composition for improving respiratory tract immunity are prepared by an aqueous extract extraction process, and the rest of components are prepared by an ultra-fine powder process, and the specific steps are as follows:
A. weighing crude drug decoction pieces of each component according to the formula of the composition for improving respiratory tract immunity;
B. placing crude drug decoction pieces of a part of the components in a traditional Chinese medicine powder grinding machine for preliminary grinding, passing through a No. 4 sieve or a No. 5 sieve, and then grinding by an ultrafine grinder to obtain ultrafine powder for later use; the rotational speed of the superfine pulverizer is 300-400 rpm, the pulverizing time is 20-40 min, the ball-to-material ratio (5-20): 1, and the ratio of the big ball to the small ball is 1 (1-6);
C. the crude drug decoction pieces of the rest components are not required to be smashed or smashed and then pass through a standard sieve with 3 meshes to 5 meshes, water with 10 to 15 times of volume is added after the mixture is evenly mixed, heating reflux is carried out for 1.5 to 3 hours at the temperature of 90 to 100 ℃, the obtained extract is filtered by a sieve with 150 meshes to 300 meshes, heating extraction is repeated for 1 to 3 times and filtering, all the filtrates are combined, vacuum concentration is carried out to 1/5 to 1/10 of the volume of the original filtrate under the conditions of the temperature of 50 to 70 ℃ and the vacuum degree of 70 to 100mbar, and then the concentrated liquid is freeze-dried to obtain freeze-dried powder of the water extract for standby;
D. and then mixing the superfine powder obtained in the step B and the water extract freeze-dried powder obtained in the step C, and then placing the mixture into a superfine pulverizer to pulverize the mixture to obtain the composition for improving the respiratory tract immunity, wherein the rotating speed of the superfine pulverizer is 300-400 rpm, the pulverizing time is 20-40 min, the ball-to-material ratio is (5-20): 1, and the proportion of the big balls to the small balls is (1-6).
9. A process for preparing a plant soft candy for improving respiratory tract immunity as recited in claim 1, comprising the steps of:
s1, colloid preparation: weighing 10-14 parts of colloid, adding 17-20 parts of water, swelling for 1-2 hours, and heating to 70-80 ℃ to melt for later use;
s2, sugar boiling: weighing 30-50 parts of substituted sugar, and boiling to 100-120 ℃ to form sugar liquid for later use;
s3, blending: and (3) cooling the sugar solution in the step (S2) to 80-90 ℃, adding the colloid prepared in the step (S1) into the sugar solution, uniformly mixing, adding the composition for improving the respiratory tract immunity and the sour regulator, uniformly stirring, and then sequentially carrying out injection molding, cooling and demolding to obtain the plant soft candy with the gel soft candy dosage form for improving the respiratory tract immunity.
10. A process for preparing a plant soft candy for improving respiratory tract immunity as claimed in claim 2, comprising the steps of:
s1, colloid preparation: weighing 10-14 parts of colloid, adding 17-20 parts of water, swelling for 1-2 hours, and heating to 70-80 ℃ to melt for later use;
s2, sugar boiling: weighing 30-50 parts of substituted sugar, and boiling to 100-120 ℃ to form sugar liquid for later use;
s3, blending: cooling the sugar solution in the step S2 to 80-90 ℃, adding the colloid prepared in the step S1 into the sugar solution, uniformly mixing, then adding the composition for improving the respiratory tract immunity, the sour regulator and the buffer salt, and uniformly stirring to obtain a first mixture A;
s4, filtering: discharging the first mixture into filtering equipment, and filtering through a 40-80 mesh sieve to obtain a second mixture;
s5, filling: filling the second mixture into collagen casing, cooling and molding to obtain crude soft sweet;
s6, shearing: transferring the shaped crude soft sweet into a kinking machine and a shearing machine, and kinking and shearing to obtain soft sweet particles;
s7, drying: and (3) placing the soft candy particles into a drying room for drying for 20-60 hours to obtain the plant soft candy coated with the soft candy formulation and improving respiratory tract immunity.
11. A process for preparing a plant soft candy for improving respiratory tract immunity as claimed in claim 3, comprising the steps of:
s1, preparing an inner layer core material: taking a part of sugar substitute, boiling to 100-120 ℃ to form sugar liquid, then cooling to 80-90 ℃, adding 1-10 parts of functional composition for improving respiratory tract immunity and 0-1.2 parts of sour regulator into the mixture, and uniformly mixing to prepare an inner core material;
s2, preparing an outer leather material:
s21, colloid preparation: weighing 10-14 parts of colloid, adding 17-20 parts of water, swelling for 1-2 hours, and heating to 70-80 ℃ to melt for later use;
s22, sugar boiling: taking the rest sugar substitute, and boiling to 100-120 ℃ to form sugar liquor for standby;
s23, a blending step: cooling the sugar solution in the step S22 to 80-90 ℃, adding the colloid prepared in the step S21 into the sugar solution, uniformly mixing, then adding concentrated apple juice, and uniformly stirring to obtain an outer layer leather mixture;
s3, casting molding: and (3) conveying the outer layer skin material mixture and the inner layer core material into a storage tank of a sandwich soft sweet pouring molding machine, preserving heat at 70-80 ℃, casting and molding, cooling and solidifying, and demolding to obtain the sandwich plant soft sweet for improving respiratory tract immunity.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107029099A (en) * | 2017-04-06 | 2017-08-11 | 魏增强 | A kind of relieving cough and asthma Chinese medicine composition and preparation method |
| CN107594037A (en) * | 2017-11-06 | 2018-01-19 | 漳州开发区中欧食品产业发展中心 | Emblic plant herbal tea beverage and preparation method thereof |
| CN110637905A (en) * | 2019-09-26 | 2020-01-03 | 宁波德康生物制品有限公司 | Substitutional tea for treating pharyngitis and preparation method thereof |
| CN111567660A (en) * | 2020-05-14 | 2020-08-25 | 上海来伊份股份有限公司 | Sambucus williamsii flower flavored soft sweet and preparation method thereof |
| CN113575737A (en) * | 2021-07-26 | 2021-11-02 | 山西振东五和健康科技股份有限公司 | Smoking cessation gel candy and preparation method thereof |
| CN114073752A (en) * | 2020-08-19 | 2022-02-22 | 北京创立科创医药技术开发有限公司 | Throat clearing tea and preparation method thereof |
-
2023
- 2023-03-24 CN CN202310295068.6A patent/CN117158504A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107029099A (en) * | 2017-04-06 | 2017-08-11 | 魏增强 | A kind of relieving cough and asthma Chinese medicine composition and preparation method |
| CN107594037A (en) * | 2017-11-06 | 2018-01-19 | 漳州开发区中欧食品产业发展中心 | Emblic plant herbal tea beverage and preparation method thereof |
| CN110637905A (en) * | 2019-09-26 | 2020-01-03 | 宁波德康生物制品有限公司 | Substitutional tea for treating pharyngitis and preparation method thereof |
| CN111567660A (en) * | 2020-05-14 | 2020-08-25 | 上海来伊份股份有限公司 | Sambucus williamsii flower flavored soft sweet and preparation method thereof |
| CN114073752A (en) * | 2020-08-19 | 2022-02-22 | 北京创立科创医药技术开发有限公司 | Throat clearing tea and preparation method thereof |
| CN113575737A (en) * | 2021-07-26 | 2021-11-02 | 山西振东五和健康科技股份有限公司 | Smoking cessation gel candy and preparation method thereof |
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