CN117045757A - 一种调理新陈代谢阻碍、降低尿酸浓度的组合物及其制备方法 - Google Patents
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- A—HUMAN NECESSITIES
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Abstract
本发明公开了一种调理新陈代谢阻碍、降低尿酸浓度的组合物及其制备方法，具体涉及医药领域。所述组合物包括茯苓、陈皮、山楂、薏米、芹菜籽、淡竹叶、白茅根、薄荷、桃仁、葵花盘、罗汉果和杠板归。本发明通过采用中医古方并加以改进，选取的原料即可食用，亦可入药；找到患病原因，从而调理患者身体内在新陈代谢阻碍，疏通各脏器於堵，降解嘌呤成分，达到根除高尿酸指标，因药食同源材料，所以对人体无任何伤害。
Description
技术领域
本发明涉及医药领域，具体涉及一种调理新陈代谢阻碍、降低尿酸浓度的组合物及其制备方法。
背景技术
痛风是由尿酸盐晶体沉积于关节、肌肉、韧带处所引起的一种关节炎症性疾病。其中单核/巨噬细胞系统在痛风启动、进展及缓解中均发挥了关键作用，其病理特点是尿酸盐晶体募集的外周巨噬细胞浸润关节腔并极化为M1型巨噬细胞参与炎症的启动，M1型巨噬细胞释放IL-1β、IL-6和TNF-α等致炎性因子和蛋白酶，炎性因子和蛋白酶进一步趋化白细胞，使更多吞噬尿酸钠晶体的白细胞破裂释放出蛋白酶和炎性成分，形成恶性循环而导致炎症呈瀑布式级联放大，患处可出现不同程度的滑膜增生、软骨侵蚀及破坏，引起剧烈的疼痛；在炎症后期则极化为M2型巨噬细胞，其分泌Arg、TGF-β1、IL-4、IL-10细胞因子发挥了抗炎作用，促进痛风的缓解；其中长期持续性的高尿酸血症会引起尿酸盐结晶在肾小管中沉积，进而出现肾脏靶器官损害，可进展为痛风性肾病。因此，治疗痛风药物疗效的好坏，很大程度体现在精准抗炎、无副降酸、靶向护肾的综合作用上。
现有治疗痛风手段基本上为：服用镇痛药和手术(切除结晶体)，无法从根本上解决病痛，且对患者有伤害，镇痛药服用时间长了对患者脏器造成伤害(即毒副作用)，而手术切除结晶体并没有从根本上消除患者痛因，都只是暂时性减轻患者痛苦，患者得病原理没找到。
发明内容
为此，本发明提供一种调理新陈代谢阻碍、降低尿酸浓度的组合物及其制备方法，以解决现有治疗痛风不彻底的问题。
本发明依据中国传统的古方经典《金匮要略》组方，并顺应时代发展需要，在原组方基础上增、减四、五味同源材料，用最贴近现代人体身体结构状况，重新组合成一个新配方，目的是消除高血尿酸，清理嘌呤成份，让患者身心轻松。
本发明完全采用中医古方并加以改进(依时代发展需要，增减部分草药成分，宗旨不变：药食同源，选取原材料完全符合2018年国家87种药食同源(修订版)汇总目录中食材，即可食用，亦可入药；找到患病原因，从而调理患者身体内在新陈代谢阻碍，疏通各脏器於堵，降解嘌呤成分，达到根除高尿酸指标，因药食同源材料，所以对人体无任何伤害。
为了实现上述目的，本发明提供如下技术方案：
根据本发明第一方面提供的一种调理新陈代谢阻碍、降低尿酸浓度的组合物，所述组合物包括茯苓、陈皮、山楂、薏米、芹菜籽、淡竹叶、白茅根、薄荷、桃仁、葵花盘、罗汉果和杠板归。
此12味食药均有可替代品，如甘草可替代陈皮、薏米、茯苓，杠板归鱼腥草3-5g替代杠板归，只是剂量要少于杠板归，因鱼腥草性寒，量大易伤肠胃。
进一步的，所述组合物包括茯苓2-5份，陈皮2-5份，山楂2-5份，薏米2-5份，芹菜籽2-5份，淡竹叶1-4份，白茅根1-4份，薄荷1-4份，桃仁1-4份，葵花盘3-5份，罗汉果1-4份，杠板归5-10份。
进一步的，所述组合物包括茯苓3.5g，陈皮3.5g，山楂3.5g，薏米3.5g，芹菜籽3.5g，淡竹叶2.5g，白茅根2.5g，薄荷2.5g，桃仁2.5g，葵花盘3-5g，罗汉果2.5g，杠板归5-10g。
根据本发明第二方面提供的一种调理新陈代谢阻碍、降低尿酸浓度的组合物，所述组合物包括山楂3-5份，甘草6-15份，芹菜籽2-5份，淡竹叶1-4份，白茅根1-4份，薄荷1-4份，桃仁1-4份，葵花盘3-5份，罗汉果1-4份，杠板归5-10份。
根据本发明第三方面提供的一种调理新陈代谢阻碍、降低尿酸浓度的组合物，所述组合物包括茯苓2-5份，陈皮2-5份，山楂2-5份，薏米2-5份，芹菜籽2-5份，淡竹叶1-4份，白茅根1-4份，薄荷1-4份，桃仁1-4份，葵花盘3-5份，罗汉果1-4份，鱼腥草3-5份。
根据本发明第四方面提供的一种调理新陈代谢阻碍、降低尿酸浓度的组合物的制备方法，其特征在于，包括按比例称取原料混合后，采用高精密粉碎机碾成粉末200目-2000目粉末，灌装成条状即得。
根据本发明第五方面提供的一种调理新陈代谢阻碍、降低尿酸浓度的组合物在制备治疗痛风产品中的应用。
进一步的，所述产品为药食同源组合物、中药组合物或保健品。
茯苓是一种寄生于松树根的菌类植物，形状似甘薯，外皮黑褐色，里面白色或粉红色。茯苓功效广泛，不分四季，将其与各种药物配伍，不管寒、湿、温、风诸症，都能发挥其独特功效。具有利水渗湿、健脾和胃、养心安神之功效。
陈皮，健脾开胃、燥湿化痰。因其含有特殊芳香，能改善食欲、促进消化液分泌，增强肠道功能，缓解脘腹胀满、食欲不振、食少吐泻症状。泡水喝可起到燥湿化痰作用，可去除体内湿气，促进痰液排出，对于咳嗽痰多有一定缓解作用。现代临床常用于辅治疗支气管炎、肺炎等疾病。
山楂，消食健胃、行气散瘀、化浊降脂。因其含有丰富果酸以及有机酸，能刺激消化液分泌，改善脾胃功能、缓解泻痢腹痛、胃脘胀满、食欲不振、肉食积滞症状。山楂归脾经、胃经、肝经，还可行气散瘀，对产后瘀阻、瘀血经闭、胸痹心痛等病症有一定调理效果。此外，山楂具有化浊降脂作用，适合高脂血症患者食用。
薏米，利水消肿、健脾止泻。薏米，味甘淡、性微寒，入脾、胃、肺、大肠经。有利水消肿、健脾止泻功效。可用于治疗水肿、泄泻。薏米不但有滋补作用，还能降血压、解热。除痹、清热、排脓，功同茯苓，尤对脾虚湿盛者效果不错，同时用于风湿痹痛、筋脉挛急，因其能渗湿，又能疏筋脉，缓挛急，所以用于这一类疾病效果佳。
芹菜籽，预防高血压、壮骨、祛风除湿。芹菜籽即为芹菜种子，显种形，颜色多为棕褐色或深棕色。芹菜籽加工或粉剂可直接食用，能为人体补充多种有益的营养成分，具有预防高血压、壮骨：祛风除湿之功效。芹菜籽中含有纯天然降压成分，长期食用可辅助降压、使血压稳定。芹菜籽中还含微量元素钙和磷，是人体骨骼发育的重要成分，可促进骨骼发育，增加骨骼密度，预防骨质疏松、降低骨关节疾病的发病率。芹菜籽还具有一定的药用价值，能祛风除湿及疏通经络，对关节炎、风湿性关节炎、关节疼痛有缓解作用。另外，芹菜籽中含有的碱性成分能加快人体内尿酸代谢，患痛风的几率会明显下降。现代药理研究发现，芹菜籽中提取的丁基苯酞(Butylphthalidde.NBP)，可以有效治疗急性缺血性脑卒中(石药集团发明专利药：丁苯酞软胶囊)。
淡竹叶，清热除烦、利尿。淡竹叶上能清心火而除烦，可用于治疗热病烦渴、口舌生疮、小便赤涩、疼痛等症。淡竹叶下能利小便而渗湿，所以可治湿热黄疸等症。淡竹叶性味甘，淡、寒，与温补辅助的药物和辛辣食物同用，可降低药效。现代药理研究可知，本品有退热、利尿、抗肿痛、抑菌、升高血糖等多种药理作用。
薄荷，疏散风热：解毒透疹、清利头目。薄荷是一种有特殊价值的芳香植物，中国常用药之一，既有药用价值，又有食用价值。在日常生活中，可用薄荷叶泡茶喝，有保健作用。薄荷具有疏散风热、解毒透疹：清利头目功效。疏散风热，主要用于风热感冒症，临床上表现为发烧、怕冷、嗓子疼、头痛、咳嗽、咳吐黄痰或咳痰不爽，大便偏干等感冒症状。解毒透疹，对麻疹疹出不畅，用薄荷可使麻疹透发出来，缩短病程。清利头目、通鼻窍。用于外感风热或外感风寒入里热化引起的咽喉疼痛、头痛等症状，以及二感冒或过敏引起鼻塞、流鼻涕。疏肝理气，薄荷具有疏肝解郁、理气功效。对于肝气不舒引起的协肋瘀肿、心情不畅、失眠多梦、郁郁寡欢等症状可起到缓解作用。
白茅根，凉血止血、清热生津、利尿通淋。白茅根为禾本植物，其干燥根茎呈长圆柱形，表面黄白色或淡黄色，微有光泽，体轻，质略脆，断面皮部白色，气微，味微甘。凉血止血，白茅根性寒味甘，能凉血止血，治疗血热妄行之吐血、咳血、尿血等出血症。白茅根性寒，味甘，归脾经、胃经丶膀胱经，《本草纲目》：止吐衄血诸症，伤寒哕逆，肺热喘急，水肿黄胆、解酒毒。白茅根含丰富的钾盐，可清热利尿、除湿退黄、小便不利功效较好。
桃仁，润肠通便、活血化瘀、止咳平喘，桃仁质润，有润肠通便功效，可缓解肠火筹引起的大便干结、排便困难、腹痛等病症以及跌打损伤引起的痰血肿痛。现代药理研究发现，桃仁中含有的杏仁苷具有止咳平喘功效，有助于缓解咳嗽、气喘等症状。
葵花盘，清热平肝、止血止痛、降压。葵花盘性寒、归肝经，对于肝阳上亢导致的头晕耳鸣、舌红少津、头重脚轻等症状有一定治疗效果。葵花盘还具有止血止痛作用，适用于治疗崩漏、痛经、脘腹痛、尿血、子宫出血等病症。此外，现代药理研究表明，葵花盘能够扩张周围血管、降低血压、减慢心率、保护心血管，适合高血压患者。葵花盘粉中的有效成分对降低血尿酸有显著作用。痛风属风湿免疫病范畴，是一种代谢紊乱症，根本原因是由于嘌呤代谢阻碍导致体内嘌呤含量高引起的免疫疾病。其发病与否与血尿酸升高有密切关系，通过降低血尿酸浓度而减少痛风发病率。除此之外，多饮水、减重、减少摄入高嘌呤食物，增加碱性食物摄入量，也是一种降低痛风发病的好办法。
罗汉果，清热生津、解表除烦、润肠通便。罗汉果味甘、性凉；归肺、大肠经。具有清肺热作用，常用于治疗咽喉肿痛、声音嘶哑。此外，罗汉果还可用于治疗肠热便秘、食欲不振、消化不良等；还可用于治疗毛玻璃肺结节。毛玻璃结节是指肺部的一种毛玻璃影，它密度比较高，边界比较清楚。现代研究显示，罗汉果有降低血清谷丙转氨酶活力作用，能较显著提高动物外固血酸性醋酸奈酷酶阳性淋巴细胞的百分率，提示可增强机体的细胞免疫功能。本组方无任何添加剂、无催化剂等额外物质，所有成分均来自天然食材(大地上生长的植物)。
本发明具有如下优点：
本发明整体调理患者新陈代谢紊乱问题，降低血尿酸浓度，新陈代谢受阻问题解决好了，身体各结构得到疏通，患者身体自然健康了，并且服用剂量无需严格控制，根据自己疼痛程度可增可减，当食品服用。
本发明依据中国传统的古方经典《金匮要略》组方，并顺应时代发展需要，在原组方基础上增、减四、五味同源材料，用最贴近现代人体身体结构状况，重新组合成一个新配方，目的是消除高血尿酸，清理嘌呤成份，让患者身心轻松。
本发明完全采用中医古方并加以改进(依时代发展需要，增减部分草药成分，宗旨不变：药食同源，选取原材料完全符合2018年国家87种药食同源(修订版)汇总目录中食材，即可食用，亦可入药；找到患病原因，从而调理患者身体内在新陈代谢阻碍，疏通各脏器於堵，降解嘌呤成分，达到根除高尿酸指标，因药食同源材料，所以对人体无任何伤害。
本发明的制备方法简单：只需添置一台高精度粉碎机，尽量达到纳米级细微颗粒，这样能直接穿透细胞膜被吸收，使尿酸快速排出体外。
具体实施方式
以下由特定的具体实施例说明本发明的实施方式，熟悉此技术的人士可由本说明书所揭露的内容轻易地了解本发明的其他优点及功效，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
本实施例提供一种调理新陈代谢阻碍、降低尿酸浓度的组合物：
茯苓3.5g，陈皮3.5g，山楂3.5g，薏米3.5g，芹菜籽3.5g，淡竹叶2.5g，白茅根2.5g，薄荷2.5g，桃仁2.5g，葵花盘4g，罗汉果2.5g，杠板归8g。
实施例2
本实施例提供一种调理新陈代谢阻碍、降低尿酸浓度的组合物：
茯苓2g，陈皮2g，山楂2g，薏米2g，芹菜籽2g，淡竹叶1g，白茅根1g，薄荷1g，桃仁1g，葵花盘3g，罗汉果1g，杠板归5g。
实施例3
本实施例提供一种调理新陈代谢阻碍、降低尿酸浓度的组合物：
茯苓5g，陈皮5g，山楂5g，薏米5g，芹菜籽5g，淡竹叶4g，白茅根4g，薄荷4g，桃仁4g，葵花盘5g，罗汉果4g，杠板归10g。
实施例4
本实施例提供一种调理新陈代谢阻碍、降低尿酸浓度的组合物：
山楂3.5g，甘草10.5g，芹菜籽3.5g，淡竹叶2.5g，白茅根2.5g，薄荷2.5g，桃仁2.5g，葵花盘4g，罗汉果2.5g，杠板归8g。
实施例5
本实施例提供一种调理新陈代谢阻碍、降低尿酸浓度的组合物：
甘草6g，山楂2g，芹菜籽2g，淡竹叶1g，白茅根1g，薄荷1g，桃仁1g，葵花盘3g，罗汉果1g，杠板归5g。
实施例6
本实施例提供一种调理新陈代谢阻碍、降低尿酸浓度的组合物：
山楂5g，甘草15g，芹菜籽5g，淡竹叶4g，白茅根4g，薄荷4g，桃仁4g，葵花盘5g，罗汉果4g，杠板归10g。
实施例7
本实施例提供一种调理新陈代谢阻碍、降低尿酸浓度的组合物：
茯苓3.5g，陈皮3.5g，山楂3.5g，薏米3.5g，芹菜籽3.5g，淡竹叶2.5g，白茅根2.5g，薄荷2.5g，桃仁2.5g，葵花盘4g，罗汉果2.5g，鱼腥草4g。
实施例8
本实施例提供一种调理新陈代谢阻碍、降低尿酸浓度的组合物：
茯苓2g，陈皮2g，山楂2g，薏米2g，芹菜籽2g，淡竹叶1g，白茅根1g，薄荷1g，桃仁1g，葵花盘3g，罗汉果1g，鱼腥草3g。
实施例9
本实施例提供一种调理新陈代谢阻碍、降低尿酸浓度的组合物：
茯苓5g，陈皮5g，山楂5g，薏米5g，芹菜籽5g，淡竹叶4g，白茅根4g，薄荷4g，桃仁4g，葵花盘5g，罗汉果4g，鱼腥草5g。
实施例10
本实施例提供一种调理新陈代谢阻碍、降低尿酸浓度的组合物的制备方法：
称取原料混合，采用高精密粉碎机碾成粉末200目-2000目粉末，灌装成条状即得。
实验例1
通过对120例痛风患者服用本组合方跟踪监测(服用本组方剂前的三甲医院所做血尿酸检测(生化24项，主要血尿酸指标)，第一组为中、轻症者，即尿酸指标不到350的80例；第二组为重症患者350—700及以上的40例；第一组服用本组方剂连续服用7天量，每天上午、下午各一条(每条含量4g)，第二组，加量×2条，上、下午各2条；无餐前、餐后要求。服用本品同时，要求患者多饮温白开水，更好帮助代谢，清理肠胃。
第一组80人，第三天关节疼痛感消失，匀速步行亦无痛感：此类人群72例，均回复无疼痛感，并在同一家三甲医院做一次生化24项检测，尿酸指标恢复正常值；有效率达90％。
第二组40人，其中血尿酸指标500及以上至700多的26例，加量每天上、下午各二条，连续服用14天，26例患者亲述第三、四天疼痛感减轻，但第七、八天疼痛感加强，因尿酸指标超过500者大多都有关节部位形成结晶，而结晶在溶解过程中尿酸会升高，所以患者陈述结晶部位的关节更痛，继续服用完毕，第十四天即无痛感，仅快速步行踝关节会有少许痛感；有效率达100％；剩余14人中，有12人陈述，第四天或第五天疼痛感减轻，7天疼痛感剋完全消失。
虽然，上文中已经用一般性说明及具体实施例对本发明作了详尽的描述，但在本发明基础上，可以对之作一些修改或改进，这对本领域技术人员而言是显而易见的。因此，在不偏离本发明精神的基础上所做的这些修改或改进，均属于本发明要求保护的范围。
Claims (8)
1.一种调理新陈代谢阻碍、降低尿酸浓度的组合物，其特征在于，所述组合物包括茯苓、陈皮、山楂、薏米、芹菜籽、淡竹叶、白茅根、薄荷、桃仁、葵花盘、罗汉果和杠板归。
2.根据权利要求1所述的一种调理新陈代谢阻碍、降低尿酸浓度的组合物，其特征在于，所述组合物包括茯苓2-5份，陈皮2-5份，山楂2-5份，薏米2-5份，芹菜籽2-5份，淡竹叶1-4份，白茅根1-4份，薄荷1-4份，桃仁1-4份，葵花盘3-5份，罗汉果1-4份，杠板归5-10份。
3.根据权利要求1所述的一种调理新陈代谢阻碍、降低尿酸浓度的组合物，其特征在于，所述组合物包括茯苓3.5g，陈皮3.5g，山楂3.5g，薏米3.5g，芹菜籽3.5g，淡竹叶2.5g，白茅根2.5g，薄荷2.5g，桃仁2.5g，葵花盘3-5g，罗汉果2.5g，杠板归5-10g。
4.一种调理新陈代谢阻碍、降低尿酸浓度的组合物，其特征在于，所述组合物包括山楂3-5份，甘草6-15份，芹菜籽2-5份，淡竹叶1-4份，白茅根1-4份，薄荷1-4份，桃仁1-4份，葵花盘3-5份，罗汉果1-4份，杠板归5-10份。
5.一种调理新陈代谢阻碍、降低尿酸浓度的组合物，其特征在于，所述组合物包括茯苓2-5份，陈皮2-5份，山楂2-5份，薏米2-5份，芹菜籽2-5份，淡竹叶1-4份，白茅根1-4份，薄荷1-4份，桃仁1-4份，葵花盘3-5份，罗汉果1-4份，鱼腥草3-5份。
6.一种调理新陈代谢阻碍、降低尿酸浓度的组合物的制备方法，其特征在于，包括按比例称取原料混合后，采用高精密粉碎机碾成粉末200目-2000目粉末，灌装成条状即得。
7.一种调理新陈代谢阻碍、降低尿酸浓度的组合物在制备治疗痛风产品中的应用。
8.根据权利要求7所述的应用，其特征在于，所述产品为药食同源组合物、中药组合物或保健品。
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