CN116963772A - 抗人mac-1的单克隆抗体及其用途 - Google Patents
抗人mac-1的单克隆抗体及其用途 Download PDFInfo
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- CN116963772A CN116963772A CN202180094281.XA CN202180094281A CN116963772A CN 116963772 A CN116963772 A CN 116963772A CN 202180094281 A CN202180094281 A CN 202180094281A CN 116963772 A CN116963772 A CN 116963772A
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
本发明提供了抗人Mac‑1的单克隆抗体。这些抗体可以与不同状态的Mac‑1结合，从而改变Mac‑1的生物功能。这些抗体可以通过TLR活化的免疫细胞调节Th1/Th2细胞因子分泌，并且可用于治疗与急性和慢性炎症性病症相关的疾病，例如感染性疾病和癌症。
Description
背景技术
巨噬细胞-1抗原(Mac-1，整合素αMβ2)主要表达于先天免疫细胞(包括单核细胞、嗜中性粒细胞、NK细胞等)的表面。Mac-1是一种异二聚体糖蛋白，包含非共价连接的整合素αM(CD11b、CR3A、ITGAM)和整合素β2(CD18、ITGB2)。CD11b是一种跨膜蛋白，具有一个大的胞外结构域和一个短的胞质尾。其胞外结构域包含I结构域、β螺旋桨(β-propeller)结构域、腿(thigh)结构域、calf-1结构域和calf-2结构域。CD11b的I结构域有大约179个氨基酸插入β螺旋桨结构域。该I结构域负责结合混杂配体(例如iC3b、纤维蛋白原、ICAM-1、CD40L等)，并参与细胞粘附、迁移、趋化和吞噬作用，并调节先天免疫细胞的炎症反应。
与其它整合素一样，Mac-1以具有不同配体结合亲和力的不同构象存在。如图1所示，CD11b和CD18弯曲成V形，I结构域靠近膜，形成无活性的Mac-1(低亲和力)。由内向外的信号传导将Mac-1改变为开放的构象，将I结构域从膜上伸展开，以获得最佳的配体结合。位于CD18的I-EGF2上的一个表位在弯曲构象中隐藏(失活或闭合状态)；在伸展或开放状态下，该表位暴露出来并且可被单克隆抗体(KIM127)识别(J.Immunol.2001；166:5629-5637)。这种构象变化也导致I结构域位点的重排，从而成为配体结合的高亲和力位点，并形成单克隆抗体m24结合的表位(Proc.Natl.Acad.Sci.USA.2004；101:2333-2338)。伴随配体结合亲和力变化的此类构象变化与Mac-1功能相关。
发明内容
本发明的实施方案涉及可特异性结合Mac-1并调节免疫细胞功能的抗体。这些抗体可用于治疗多种与Mac-1相关的疾病或障碍，例如感染性疾病或癌症。
本发明的一个方面涉及抗人Mac-1抗体。根据本发明的一个实施方案，抗人Mac-1抗体包含选自表1所示的SEQ ID NO：1至SEQ ID NO：158的轻链可变区序列和重链可变区序列。
本发明的一个方面涉及用于治疗与Mac-1相关的病症的方法。根据本发明一个实施方案的方法包括向有此需要的对象给药有效量的本发明抗体。该病症是急性或慢性炎症。该病症可以是感染或癌症。
根据以下说明和相关附图，本发明的其它方面将变得显而易见。
附图说明
图1显示了Mac-1的两种构象及其活化敏感性单克隆抗体的表位；
图2显示了使用多种抗体表征HEK293/Mac-1的结果；在PBS(空白对照)或PBS/MnCl2(Mn2+)中孵育HEK293细胞；使用流式细胞术检测同种型对照IgG、CD11b特异性单克隆抗体(克隆ICRF44)、CD18特异性单克隆抗体(克隆6.7)或β2活化依赖性单克隆抗体(KIM127和m24)的结合；
图3A显示了本发明的代表性抗Mac-1抗体(DF3M-5、H4L2、m2396、24G05和28E07-HH)主要与骨髓免疫细胞(单核细胞和嗜中性粒细胞)结合；本发明的其它抗体显示出类似的特性；
图3B显示了克隆m2396、DF3M-5和24G05与表达小鼠Mac-1的细胞系Raw264.7结合；
图4显示了可在PBS(空白对照)或PBS/MnCl2(Mn2+)条件下调节Mac-1构象变化的抗Mac-1抗体的实例；
图5显示抗Mac-1抗体治疗可在体内调节小鼠中TLR4激动剂诱导的Th1/Th2细胞因子反应；数据显示为平均值±标准误差(每组4只小鼠)；
图6显示抗Mac-1抗体在体内减少了携带A549人肺肿瘤的人源化NOG-EXL小鼠模型中的肿瘤生长；数据显示为平均值±标准误差(每组10只小鼠)；
图7A显示抗Mac-1抗体增强了分离自HIV患者的髓样细胞中功能标志物的表达；
图7B显示抗Mac-1抗体降低了来自HIV患者的PBMC中的病毒载量。
具体实施方式
本发明的实施方案涉及可特异性结合Mac-1并调节免疫细胞功能的抗体。这些抗体可用于治疗多种与Mac-1相关的疾病或障碍，例如感染性疾病或癌症。
构建并筛选人抗体和小鼠抗体噬菌体展示文库以分离携带可识别Mac-1的特异性抗体基因的克隆。这些抗Mac-1抗体显示结合HEK293/Mac-1细胞和先天免疫细胞上的Mac-1。这些抗体可以选择性地结合Mac-1的不同状态(弯曲或伸展/开放构象)并调节Mac-1的构象变化。这些抗Mac-1抗体显示出调节TLR诱导的细胞因子产生，因此可用于治疗急性和慢性炎性病症，例如感染性疾病(参考文献：WO 2020/033929 A1)和癌症(参考文献：WO 2019/177669A1和WO 2016/197974 A1)。
下文描述了本发明各方面的具体实例。本领域技术人员将理解，这些具体实例仅用于说明，并且在不脱离本发明的范围的情况下，其它修改和变化也是可能的。
材料和方法
试剂和抗体
用于流式细胞术的抗体和试剂是KIM127(来自ATCC的杂交瘤)、m24-PE(BioLegend)、抗CD11b-APC(克隆ICRF44，BioLegend)、抗CD18-APC(克隆6.7，BD)、BSA(BioShop)、大鼠IgG1κ-APC(BioLegend)和大鼠IgG1κ-PE(BioLegend)。KIM127抗体和BSA与CF647偶联，即，用CF647标记试剂盒(CF Dye&Biotin SE蛋白质标记试剂盒，Biotium)标记。
细胞培养和稳定转染
使用(PolyPlus)转染方案在HEK293细胞(BCRC)中稳定转染人整合素Mac-1。简言之，在添加10％热灭活胎牛血清(Gibco)和50IU/mL青霉素和链霉素(Corning)的杜氏改良伊格尔培养基(DMEM，Corning)中，在37℃培养HEK293细胞。将细胞以8×105个细胞/孔接种在6孔板(Coster)上。第二天，将/>试剂和2μg携带潮霉素抗性基因的pcDNA 3.1/人CD18表达质粒的混合物加入到细胞中，并将细胞培养24小时。以200μg/ml的浓度加入选择抗生素潮霉素B(InvivoGen)，并且每2至3天更换一半含有抗生素的培养基。3周后，使用细胞分选仪(SH800Z，SONY)收集CD18表达细胞以挑选CD18高表达细胞，并以单细胞/孔和5000个细胞/孔接种在24孔板(Coster)和6孔板上。在37℃，将细胞维持在含有10％热灭活胎牛血清、50IU/mL青霉素和链霉素以及200μg/ml潮霉素B的DMEM培养基中。在富集细胞后，通过流式细胞术用抗人CD18-APC(克隆6.7，BD)抗体分析人CD18表达。将永久HEK 293/人CD18细胞(克隆2B4)以6×105个细胞/孔接种在6孔板上。人CD11b的转染方案同上。简言之，将2μg pc DNA 3.1/人CD11b质粒与/>试剂混合并加入细胞中。接下来的几天，添加选择抗生素1mg/ml G418(InvivoGen)和/>g/ml潮霉素B，并且每2至3天更换含有选择抗生素的培养基。通过流式细胞术用抗人CD11b-APC(克隆ICRF44，BioLegend)和抗hCD18-APC测量Mac-1表达。挑选出了稳定的克隆1-4。
流式细胞术
对HEK293/Mac-1细胞(克隆1-4)进行计数，并用染色缓冲液(含1％FBS和0.1％叠氮化钠的PBS)洗涤两次。在染色缓冲液中以1×105个细胞/ml的浓度调节细胞，并用/不用0.25mM MnCl2(Sigma)处理。用抗Mac-1抗体和荧光偶联的抗人IgG4抗体处理细胞，并孵育15分钟。用染色缓冲液洗涤后，用流式细胞术分析细胞。在一些实例中，在存在或不存在10μg/ml抗Mac-1抗体的情况下，用抗体(ICRF44、KIM127、m24或同种型对照)处理这些细胞。然后将细胞在37℃孵育30分钟。用染色缓冲液洗涤后，用流式细胞术分析细胞。
细胞因子测量
对Balb/c小鼠(n＝4/组)腹膜内注射5mg/kg LPS和10mg/kg抗Mac-1抗体达4小时。通过ProcartaPlex MS(Thermo Fisher Scientific)，根据制造商说明，检测血清中的鼠Th1和Th2细胞因子。
癌症治疗方案
将人脐带血衍生的CD34+细胞经由尾静脉移植到NOG-EXL小鼠中。移植后约10周，在麻醉下从人源化NOG-EXL动物中收集外周血，用于FACS分析。分析免疫细胞(T细胞、B细胞、树突细胞和单核细胞)的类型、比例、荧光强度和绝对计数。当平均hCD45+％>15％、hCD3+占hCD45+％>3％以及hCD14+占hCD45+％>5％时，将人源化NOG-EXL动物用于抗癌研究。
在含5％ CO2和10％ FBS的F-12K培养基的37℃培养箱中培养人肺癌A549细胞。在接种到小鼠之前，细胞在10代内进行传代培养。在皮下注射之前，将A549细胞(5×106个细胞)与体积为200μl的基质胶(Matrigel)(体积比1:1)混合。接种前，用2％-5％异氟烷麻醉小鼠。
当肿瘤体积达到20mm3-50 mm3时，基于人CD45+细胞中的巨噬细胞的频率、人CD45+细胞中的CD3+细胞的频率和肿瘤体积，将携带肿瘤的动物分成3组，每组含有10只小鼠。分组的那一天表示为第0天。小鼠在第0天接受治疗。
肿瘤体积：肿瘤体积计算如下：V＝(长×宽2)/2。在接种、分组和给药期间，每周两次测量并记录肿瘤体积。肿瘤生长抑制率(TGI)计算如下：TGI＝(1-(T/C))×100％；T和C分别为测量当天治疗组和对照组的平均肿瘤体积。
感染性疾病治疗方案
分离自艾滋病患者的PBMC
在中国台湾大学医院(中国台湾台北)招募了15位接受常规高效抗逆转录病毒疗法(ART)治疗的HIV-1感染患者，其检测不到血浆病毒载量(<50个HIV-1RNA拷贝/mL)和可计数的CD4细胞(计数>200/mm3)。从病历中收集并获得临床和实验室数据。每个血液样本在采集后24小时内进行处理，并分离白细胞用于进一步检查。该研究由中国台湾大学医院(中国台湾台北)的机构审查委员会批准，并获得每位参与者的书面知情同意。
通过Ficoll-Paque(Amersham Biosciences，瑞典)梯度离心从全血样品中分离外周血单核细胞(PBMC)。在96孔U形底培养板(2×105个细胞/孔)中培养细胞，并在存在10μg/ml人IgG4抗体(BioLegend)或抗Mac-1抗体(克隆H4L2)的情况下，将细胞重悬于含有10％胎牛血清(FBS)、100nM埃替拉韦(Cayman)和100nM依法韦仑(Cayman)的RPMI-1640培养基中3天。
HIV患者PBMC的功能标志物检测
在用荧光染料标记的抗体染色之前，将细胞悬浮液与含1％ FBS和0.1％叠氮化钠的PBS中的Fc阻断剂(BD Bioscience)一起孵育。抗CD11b(克隆ICRF44，BioLegend)、CD86(克隆2331，BioLegend)、HLA-DR(克隆L243，BioLegend)和CD80(克隆L307，BD)的抗体用于标志物染色。使用FVS786活力染色以从分析中排除死亡细胞。通过CytoFlex流式细胞仪测量染色细胞的平均荧光强度并通过Kaluza软件(Beckman Coulter)进行分析。
细胞内HIV病毒检测-2长末端重复序列(LTR)-DNA环定量
在人IgG4抗体(BioLegend)或抗Mac-1抗体(H4L2，10μg/ml)存在下，用/不用PMA(100ng/ml)和肌霉素(1μg/ml)处理的3天培养的PBMC(在24孔培养板中，3×106个细胞/孔)的DNA用QIAamp DNA血液迷你试剂盒(Qiagen，美国马里兰州)进行提取，并用50μl无核酸酶的水洗脱DNA。使用QX100TM Droplet DigitalTM PCR平台(Bio-Rad，加利福尼亚州赫拉克勒斯)进行数字PCR。通过向10μl 2x ddPCRTM super mix for probes(Bio-Rad)、1μl EcoR、500nM引物和250nM探针中加入1-5μl样品，制成dd PCR混合物，最终体积为20μl。将混合物置于8通道样品管中，加入70μl液滴生成油(Bio-Rad)，在QX100TM液滴生成器(Bio-Rad)中生成液滴。将油悬浮液中的液滴转移到ddPCR 96孔板(Bio-Rad)中，并在T100TM热循环仪(Bio-Rad)中进行PCR。ddPCR扩增反应包括95℃下10分钟的初始变性，随后进行95℃下15秒变性和60℃下60秒退火/延伸温度的40个循环，以及98℃下10分钟的酶失活。每步的升温速率为2℃/秒。引物对的序列列于表6中。
统计分析
根据情况，通过针对分类变量的Fisher精确检验和针对连续变量的成对t检验或非成对t检验，来比较结果。数据以平均值±标准误差报告。使用Prism9.0软件进行统计分析。使用双侧检验，p值<0.05被认为具有统计学意义。
结果
异二聚体CD11b/CD18(Mac-1)在HEK293细胞表面上的表达
使用脂质体转染，用pcDNA3.1/人CD11b和pcDNA3.1/人CD18质粒转染不表达内源性Mac-1的HEK293细胞。在G418和潮霉素选择后，我们通过使用CD18特异性单克隆抗体(克隆6.7)和CD11b特异性单克隆抗体(克隆ICRF44)的FACS分选，获得了在细胞表面上稳定表达人Mac-1的几个单细胞克隆。对于本说明书中给出的所有实例，选择一个克隆，命名为1-4。其它克隆显示出类似的特性。
通过流式细胞术检测的CD11b和CD18在HEK293细胞上的表达如图2所示。我们使用两种活化敏感性抗体单克隆抗体KIM127和m24验证了HEK293/Mac-1细胞表面上的构象状态。KIM127可以与HEK293/Mac-1完全结合，表明Mac-1处于伸展构象。在PBS(空白对照)中观察到m24几乎不结合HEK293/Mac-1细胞，表明Mac-1处于低亲和力状态。PBS中的HEK293/Mac-1被部分活化。相反，Mn2+处理诱导100％的Mac-1分子采用伸展的、高亲和力的构象。因此，这些细胞为筛选人Mac-1的单克隆抗体提供了极好的平台。
抗Mac-1抗体选择性结合HEK293/Mac-1细胞表面上不同状态的Mac-1
我们构建了人抗体和小鼠抗体噬菌体展示文库，然后筛选并分离了携带可识别Mac-1的特异性抗体基因的克隆。从每轮选择的噬菌体库中挑选出总共79个克隆。这些克隆可变区的氨基酸序列列于表1和表7中。为了证实这些克隆能够以其天然构象与Mac-1结合，我们从这些克隆中产生了具有人IgG4主链的重组抗体。重组抗Mac-1抗体用于HEK293/Mac-1细胞的流式细胞术分析。如表2所列，这些抗体确实可以识别HEK293/Mac-1细胞表面上的Mac-1。
Mac-1的构象变化涉及其功能的调节。我们检测这些抗体是否能识别Mac-1的不同构象。如表2所列，在用Mn2+刺激后，一些克隆选择性地结合HEK293/Mac-1细胞上Mac-1分子上的活化特异性表位(空白对照/MnCl2的比率<1)。相反，一些克隆优先识别Mac-1的休眠形式(空白对照/MnCl2的比率>1)。表1显示了所选克隆的CDR和框架区的推定氨基酸序列。
抗Mac-1抗体主要结合先天免疫细胞表面上的Mac-1
先天免疫细胞例如单核细胞(CD14+细胞)和嗜中性粒细胞(CD66b+细胞)是在其细胞表面上表达Mac-1的主要细胞。一些B细胞群体也在其细胞表面上表达Mac-1(Proc NatlAcad Sci U S A.2008年4月1日；105(13):5195-200)。使用人全血通过流式细胞术测定选择性抗Mac-1抗体的特异性。如图3A所示，在该实例中的抗Mac-1抗体能够结合先天免疫细胞(CD14+和CD66b+细胞)和少量B细胞(CD19+细胞)。相反，这些抗体不与T细胞(CD3+淋巴细胞)结合。总之，这些结果表明抗Mac-1抗体可以特异性结合免疫细胞上的Mac-1表位。为了确定针对人Mac-1验证的抗Mac-1抗体是否会与小鼠Mac-1交叉反应，我们使用了在细胞表面上表达小鼠Mac-1的Raw 264.7小鼠巨噬细胞系。如图3B所示，一些克隆，例如DF3M-5、m2396和24G05可以结合到Raw 264.7的表面，表明这些克隆可以与小鼠Mac-1交叉反应。
抗Mac-1抗体诱导Mac-1的构象变化
众所周知，由内向外的信号传导诱导Mac-1的整体构象变化，导致由外向内的信号传导。为了筛选哪些抗Mac-1抗体会诱导Mac-1的构象变化，我们使用了KIM127和m24抗体，它们在伸展构象中优先结合Mac-1，作为检测构象变化的报告分子。如图4的左图所示，抗体与HEK293/Mac-1细胞在PBS缓冲液(空白对照)中的孵育导致基础水平的KIM127和m24结合。相反，抗体与HEK293/Mac-1细胞在MnCl2/PBS缓冲液(Mn2+)中的孵育诱导了最大水平的KIM127和m24结合(图4右图)。在空白对照条件下与DF3M-5的孵育诱导了KIM127结合的少量增加和m24结合的大量增加(图4左图)，表明该DF3M-5克隆可以作为激动剂来增强Mac-1的构象变化。可用作激动剂的其它克隆(基于m24表达相对IgG4对照>1)列于表3中。相比之下，在Mn2+条件下与28E07的孵育诱导了KIM127结合的少量减少和m24结合的大量减少(图4右侧)，表明该28E07克隆可以作为拮抗剂以减少Mac-1的构象变化。可用作拮抗剂的其它克隆(基于m24表达相对IgG4对照<1)列于表4中。这些研究结果表明，本发明的抗体可以选择性地用于控制Mac-1的构象变化，从而调节Mac-1的功能。
抗Mac-1抗体通过体内TLR活化的免疫细胞调节Th1/Th2细胞因子分泌
先前的研究表明，活性CD11b整合素参与MyD88和TRIF途径的串扰，并调节先天免疫反应中的TLR信号转导(Nat Immunol.2010年8月；11(8):734-42)。为了检测本发明的抗Mac-1抗体是否能在体内调节TLR活化的免疫细胞中的Th1/Th2细胞因子分泌，对Balb/c小鼠(n＝4/组)腹膜内注射5mg/kg LPS和10mg/kg抗Mac-1抗体。4小时之后，通过ProcartaPlexTM MS测量血清Th1/Th2细胞因子。如图5所示，m2396和DF3M-5处理增强了血清中TLR4诱导的Th1细胞因子(例如IFN-γ、IL-1β和TNF-α)，并略微增强了TLR4诱导的Th2细胞因子(例如IL-5和IL-13)。这些结果表明，抗Mac-1抗体(克隆m2396和DF3M-5)处理可以使TLR诱导的Th1/Th2反应产生偏差。相反，24G05处理没有改变Th1/Th2细胞因子谱。
抗Mac-1抗体治疗减少肿瘤生长
在雌性NOG-EXL人源化小鼠中A549癌症模型的治疗中，进一步评估了本发明的抗Mac-1抗体(例如，m2396和28E07-HH)的抗癌活性。
当平均肿瘤体积达到约41mm3时，将携带肿瘤的小鼠随机分成3组(人IgG4、m2396和28E07-HH)并开始治疗。分组后第35天，小鼠的平均肿瘤尺寸在人IgG4组中达到172.59mm3，在m2396组中达到132.51mm3，在28E07-HH组中达到109.88mm3(图6)。图6显示了代表性抗体m2396和28E07-HH的结果。本发明的其它抗体具有类似的特性。m2396组和28E07-HH组的肿瘤生长抑制率(TGI)分别为23.59％和35.93％。不同组在不同时间点的TGI如表5所示。这些结果表明，这些抗Mac-1抗体可用作治疗人类癌症的治疗性抗体。
抗Mac-1抗体治疗降低了HIV患者中的HIV病毒载量并逆转了PBMC的免疫抑制表型
为了检测抗Mac-1抗体介导的对HIV的抑制作用的效力，在体外用抗Mac-1抗体对分离自15位潜伏HIV感染患者的PBMC进行3天处理。如图7A所示，抗Mac-1抗体(H4L2显示为抗Mac-1抗体的代表)显著增强了HIV患者骨髓细胞中CD86和MHC II类功能标志物的表达。这些结果表明，用本发明的抗Mac-1抗体可以实现增强HIV患者的T细胞活化和树突细胞(DC)成熟。这些增强的免疫反应可能暗示了本发明的抗体在治疗HIV感染中的潜在应用。
尽管联合抗逆转录病毒疗法(ART)可抑制HIV复制。HIV-1作为稳定的整合基因组和更不稳定的非整合DNA存在于感染细胞中，包括线性、1-LTR和2-LTR环状DNA。2-LTR环状DNA虽然不太丰富，但被认为是近期感染事件的替代标志物，目前被用作诊断工具(C.Orlandi等人,“未整合的HIV-1DNA测量作为控制和不控制病毒复制的患者血液中细胞储库的潜在生物标志物的比较分析(A comparative analysis of unintegrated HIV-1DNA measurement as a potential biomarker of the cellular reservoir in theblood of patients controlling and non-controlling viral replication),”J.Transl.Med.18,204(2020).Doi:10.1186/s12967-020-02368-y)。
为了检测细胞内HIV病毒的载量，使用2个长末端重复(LTR)DNA环作为标志物来量化HIV病毒DNA库。因为这15位感染HIV-1病毒的患者正在接受常规的高效抗逆转录病毒疗法(ART)治疗，所以15位患者中只有3位通过LTR测定具有可检测的HIV DNA水平。然而，在用抗Mac-1抗体或用抗Mac-1抗体与佛波醇12-肉豆蔻酸13-乙酸酯(PMA)和肌霉素联合治疗的这3位患者的PBMC样品中，观察到HIV 2LTR DNA水平的下降(图7B)。
虽然本发明已通过有限数量的实例进行了描述，但本领域技术人员应理解，这些实例仅用于说明，在不脱离本发明范围的情况下，其它修改和变化也是可能的。因此，保护范围应该仅由所附权利要求来限定。
表格
表1：SEQ ID NO：1至SEQ ID NO：158的重链可变区序列和轻链可变区序列
抗Mac-1抗体序列克隆：24F08(下划线是CDR序列)
抗Mac-1抗体序列克隆：24F09(下划线是CDR序列)
抗Mac-1抗体序列克隆：24F11(下划线是CDR序列)
抗Mac-1抗体序列克隆：24F12(下划线是CDR序列)
抗Mac-1抗体序列克隆：24G01(下划线是CDR序列)
抗Mac-1抗体序列克隆：24G05(下划线是CDR序列)
抗Mac-1抗体序列克隆：24G07(下划线是CDR序列)
抗Mac-1抗体序列克隆：24G08(下划线是CDR序列)
抗Mac-1抗体序列克隆：24G09(下划线是CDR序列)
抗Mac-1抗体序列克隆：24G10(下划线是CDR序列)
抗Mac-1抗体序列克隆：24G11(下划线是CDR序列)
抗Mac-1抗体序列克隆：24G12(下划线是CDR序列)
抗Mac-1抗体序列克隆：24H01(下划线是CDR序列)
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抗Mac-1抗体序列克隆：24H02(下划线是CDR序列)
抗Mac-1抗体序列克隆：24H03(下划线是CDR序列)
抗Mac-1抗体序列克隆：25A02(下划线是CDR序列)
抗Mac-1抗体序列克隆：25A04(下划线是CDR序列)
抗Mac-1抗体序列克隆：25A06(下划线是CDR序列)
抗Mac-1抗体序列克隆：25A09(下划线是CDR序列)
抗Mac-1抗体序列克隆：25A10(下划线是CDR序列)
抗Mac-1抗体序列克隆：25B03(下划线是CDR序列)
抗Mac-1抗体序列克隆：25B04(下划线是CDR序列)
抗Mac-1抗体序列克隆：25B01(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF3-10(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF3-28(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF3-30(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF3-32(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4-16(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4-17(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4-22(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4-25(下划线是CDR序列)
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抗Mac-1抗体序列克隆：DF4-26(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4-42(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF3M-1(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF3M-2(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF3M-5(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF3M-18(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF3M-19(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF3M-30(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF3M-36(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF3M-42(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-1(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-3(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-7-1(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-7-4(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-9(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-11(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-17(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-18(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-21(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-23(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-30(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-31(下划线是CDR序列)
抗Mac-1抗体序列克隆：DF4M-45(下划线是CDR序列)
抗Mac-1抗体序列克隆：28E07(下划线是CDR序列)
抗Mac-1抗体序列克隆：28A12(下划线是CDR序列)
抗Mac-1抗体序列克隆：27G04(下划线是CDR序列)
抗Mac-1抗体序列克隆：27A04(下划线是CDR序列)
抗Mac-1抗体序列克隆：27A06(下划线是CDR序列)
抗Mac-1抗体序列克隆：28G06(下划线是CDR序列)
抗Mac-1抗体序列克隆：27B10(下划线是CDR序列)
抗Mac-1抗体序列克隆：27D06(下划线是CDR序列)
抗Mac-1抗体序列克隆：28D06(下划线是CDR序列)
抗Mac-1抗体序列克隆：27E12(下划线是CDR序列)
抗Mac-1抗体序列克隆：m2396(下划线是CDR序列)
抗Mac-1抗体序列克隆：H4L2(下划线是CDR序列)
抗Mac-1抗体序列克隆：28E07-HH(下划线是CDR序列)
抗Mac-1抗体序列克隆：28E07-B1H(下划线是CDR序列)
抗Mac-1抗体序列克隆：28E07-B2H(下划线是CDR序列)
抗Mac-1抗体序列克隆：28E07-B3H(下划线是CDR序列)
抗Mac-1抗体序列克隆：28E07-B4H(下划线是CDR序列)
抗Mac-1抗体序列克隆：28E07-HB1(下划线是CDR序列)
抗Mac-1抗体序列克隆：28E07-HB2(下划线是CDR序列)
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抗Mac-1抗体序列克隆：28E07-HB3(下划线是CDR序列)
抗Mac-1抗体序列克隆：28E07-HB4(下划线是CDR序列)
抗Mac-1抗体序列克隆：28E07-B1B1(下划线是CDR序列)
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抗Mac-1抗体序列克隆：28E07-B1B2(下划线是CDR序列)
抗Mac-1抗体序列克隆：28E07-B2B1(下划线是CDR序列)
抗Mac-1抗体序列克隆：28E07-B2B2(下划线是CDR序列)
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表2：抗Mac-1抗体选择性地结合不同状态的人Mac-1。在PBS(空白对照)或PBS/MnCl2(Mn2+)中孵育HEK293/Mac-1细胞(克隆1-4)。使用流式细胞术检测同种型对照IgG、CD11b特异性单克隆抗体(ICRF44)、CD11b活化感应单克隆抗体(CBRM1/5)或筛选的抗Mac-1抗体的结合。
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表3：抗Mac-1抗体可以作为激动剂来增强Mac-1的构象变化。在PBS(空白对照)条件下，将HEK293/Mac-1细胞(克隆1-4)与10μg/ml抗Mac-1抗体一起孵育。使用流式细胞术检测KIM127或m24的结合。
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表4：抗Mac-1抗体可以作为拮抗剂来减少Mac-1的构象变化。在PBS/MnCl2(Mn2+)条件下，将HEK293/Mac-1细胞(克隆1-4)与10μg/ml抗Mac-1抗体一起孵育。使用流式细胞术检测KIM127或m24的结合。
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表5：肿瘤生长抑制率(TGI，％)
表6：数字PCR中使用的引物和探针序列
表7：SEQ ID NO：159至SEQ ID NO：554的重链CDR区序列和轻链CDR区序列
抗Mac-1抗体CDR序列克隆：24F08
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：159 | CDR-H1 | GFTFSSYWMS |
| SEQ ID NO：160 | CDR-H2 | IINYSGREADYADSVKG |
| SEQ ID NO：161 | CDR-H3 | DGSYVGQAHEAFDI |
| SEQ ID NO：162 | CDR-L1 | RASQSISKYLA |
| SEQ ID NO：163 | CDR-L2 | GTSNLQS |
| SEQ ID NO：164 | CDR-L3 | QQSRSWPLT |
抗Mac-1抗体CDR序列克隆：24F09
抗Mac-1抗体CDR序列克隆：24F11
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：171 | CDR-H1 | GFTFSTSWMHW |
| SEQ ID NO：172 | CDR-H2 | IINSGGGEAYYADSVKG |
| SEQ ID NO：173 | CDR-H3 | GDAAFDY |
| SEQ ID NO：174 | CDR-L1 | RASQLIRKKLA |
| SEQ ID NO：175 | CDR-L2 | AASTLQS |
| SEQ ID NO：176 | CDR-L3 | MQSGSPQYT |
抗Mac-1抗体CDR序列克隆：24F12
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：177 | CDR-H1 | GFTFTNYWMG |
| SEQ ID NO：178 | CDR-H2 | IIISDGGEIIYADSVKG |
| SEQ ID NO：179 | CDR-H3 | IHAGTGSSADY |
| SEQ ID NO：180 | CDR-L1 | RASQSIYNYLN |
| SEQ ID NO：181 | CDR-L2 | DASTLQS |
| SEQ ID NO：182 | CDR-L3 | QQYYSYPWT |
抗Mac-1抗体CDR序列克隆：24G01
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：183 | CDR-H1 | GFTFRTFGMN |
| SEQ ID NO：184 | CDR-H2 | GIVPSGSEIDYADSVKGR |
| SEQ ID NO：185 | CDR-H3 | DHSHYTGPFDV |
| SEQ ID NO：186 | CDR-L1 | RASQSIYSYLN |
| SEQ ID NO：187 | CDR-L2 | GASILQY |
| SEQ ID NO：188 | CDR-L3 | HQSNSSPGT |
抗Mac-1抗体CDR序列克隆：24G05
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：189 | CDR-H1 | GFTFTSYWMT |
| SEQ ID NO：190 | CDR-H2 | TIVGGGGEADYADSVKG |
| SEQ ID NO：191 | CDR-H3 | DYVADNHGAMDY |
| SEQ ID NO：192 | CDR-L1 | RASQGLSSYLN |
| SEQ ID NO：193 | CDR-L2 | GMSTLQS |
| SEQ ID NO：194 | CDR-L3 | MQYYHWPYT |
抗Mac-1抗体CDR序列克隆：24G07
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：195 | CDR-H1 | GFTFSDYIMH |
| SEQ ID NO：196 | CDR-H2 | AISPSGSEIYYADSVKG |
| SEQ ID NO：197 | CDR-H3 | NAWDNNWVREYGMDY |
| SEQ ID NO：198 | CDR-L1 | RASQSGNNNLA |
| SEQ ID NO：199 | CDR-L2 | GASTLQS |
| SEQ ID NO：200 | CDR-L3 | MQSNSYPLT |
抗Mac-1抗体CDR序列克隆：24G08
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：201 | CDR-H1 | GFTFSDYKIH |
| SEQ ID NO：202 | CDR-H2 | IYADSVKG |
| SEQ ID NO：203 | CDR-H3 | SSYGEGYAFDY |
| SEQ ID NO：204 | CDR-L1 | RASQDVDSYLN |
| SEQ ID NO：205 | CDR-L2 | DAISLQS |
| SEQ ID NO：206 | CDR-L3 | QQYYSLPLT |
抗Mac-1抗体CDR序列克隆：24G09
抗Mac-1抗体CDR序列克隆：24G10
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：213 | CDR-H1 | SGFTFSSNSMS |
| SEQ ID NO：214 | CDR-H2 | AINYSGREIYYADSVKG |
| SEQ ID NO：215 | CDR-H3 | TDYNTFDY |
| SEQ ID NO：216 | CDR-L1 | RASQSNSSHLN |
| SEQ ID NO：217 | CDR-L2 | GVSNLQS |
| SEQ ID NO：218 | CDR-L3 | QHYGSTPYT |
抗Mac-1抗体CDR序列克隆：24G11
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：219 | CDR-H1 | GFTFSDYYMS |
| SEQ ID NO：220 | CDR-H2 | VISYGGGEAYYADSVKG |
| SEQ ID NO：221 | CDR-H3 | AMASEYGPWDY |
| SEQ ID NO：222 | CDR-L1 | RASQSISRHLT |
| SEQ ID NO：223 | CDR-L2 | GASTLQS |
| SEQ ID NO：224 | CDR-L3 | QQYHDWPLT |
抗Mac-1抗体CDR序列克隆：24G12
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：225 | CDR-H1 | GFTFGDDYMH |
| SEQ ID NO：226 | CDR-H2 | AINYDGSWKYYADSVKG |
| SEQ ID NO：227 | CDR-H3 | LSSIDEPPYGPFDV |
| SEQ ID NO：228 | CDR-L1 | RASQSISTYLA |
| SEQ ID NO：229 | CDR-L2 | EASSLQS |
| SEQ ID NO：230 | CDR-L3 | QQYYNFPPT |
抗Mac-1抗体CDR序列克隆：24H01
抗Mac-1抗体CDR序列克隆：24H02
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：237 | CDR-H1 | GFTFSDYWMS |
| SEQ ID NO：238 | CDR-H2 | SIVYGGSEIDYADSVKG |
| SEQ ID NO：239 | CDR-H3 | VPGYSGTPFDY |
| SEQ ID NO：240 | CDR-L1 | RASQSVSRYLA |
| SEQ ID NO：241 | CDR-L2 | DTSSLQS |
| SEQ ID NO：242 | CDR-L3 | QQSYSFPLT |
抗Mac-1抗体序列克隆：24H03(下划线是CDR序列)
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：243 | CDR-H1 | GFTFKDSWMH |
| SEQ ID NO：244 | CDR-H2 | IISYSGGEAIYADSVKG |
| SEQ ID NO：245 | CDR-H3 | DSGGSAMGFDI |
| SEQ ID NO：246 | CDR-L1 | RASQSIHSYLN |
| SEQ ID NO：247 | CDR-L2 | GASSLQS |
| SEQ ID NO：248 | CDR-L3 | QQYYRFPYT |
抗Mac-1抗体CDR序列克隆：25A02
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：249 | CDR-H1 | GFTFSDWYLH |
| SEQ ID NO：250 | CDR-H2 | VINGGGSEIIYADSVKG |
| SEQ ID NO：251 | CDR-H3 | GGDGDGSGFDD |
| SEQ ID NO：252 | CDR-L1 | RASQSIHSYLN |
| SEQ ID NO：253 | CDR-L2 | DASNLQS |
| SEQ ID NO：254 | CDR-L3 | QQSGNYPFT |
抗Mac-1抗体CDR序列克隆：25A04
抗Mac-1抗体CDR序列克隆：25A06
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：261 | CDR-H1 | GFTFSSYYMS |
| SEQ ID NO：262 | CDR-H2 | TINYDGSEKDYADSVKG |
| SEQ ID NO：263 | CDR-H3 | DRLGNYPWFDV |
| SEQ ID NO：264 | CDR-L1 | RASQSISNYLA |
| SEQ ID NO：265 | CDR-L2 | DANNLQS |
| SEQ ID NO：266 | CDR-L3 | QQSYSWPLT |
抗Mac-1抗体CDR序列克隆：25A09
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：267 | CDR-H1 | GFTFTEWWMS |
| SEQ ID NO：268 | CDR-H2 | TISYGGSEAIYADSVKG |
| SEQ ID NO：269 | CDR-H3 | TSSDRLLFDY |
| SEQ ID NO：270 | CDR-L1 | RASQSIKSSLA |
| SEQ ID NO：271 | CDR-L2 | GASTLQS |
| SEQ ID NO：272 | CDR-L3 | MQTNRHPWT |
抗Mac-1抗体CDR序列克隆：25A10
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：273 | CDR-H1 | GFTFSNYNLH |
| SEQ ID NO：274 | CDR-H2 | TISYSGSEIIYADSVKG |
| SEQ ID NO：275 | CDR-H3 | EDEYTYYYFDP |
| SEQ ID NO：276 | CDR-L1 | RASQSVSSYLA |
| SEQ ID NO：277 | CDR-L2 | DASKLQS |
| SEQ ID NO：278 | CDR-L3 | KQSYSSPPT |
抗Mac-1抗体序列克隆：25B03(下划线是CDR序列)
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：279 | CDR-H1 | GFTFSDYWMH |
| SEQ ID NO：281 | CDR-H2 | TIIGGGSEAGYADSVKG |
| SEQ ID NO：281 | CDR-H3 | DRSYGYLGFDI |
| SEQ ID NO：282 | CDR-L1 | RASQSIRNSLH |
| SEQ ID NO：283 | CDR-L2 | SAGKLQS |
| SEQ ID NO：284 | CDR-L3 | QQSNSFPLT |
抗Mac-1抗体CDR序列克隆：25B04
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：285 | CDR-H1 | GFTFSTNWMH |
| SEQ ID NO：286 | CDR-H2 | MISYSGGEAIYADSVKG |
| SEQ ID NO：287 | CDR-H3 | NWLPYAMDY |
| SEQ ID NO：288 | CDR-L1 | RASQSIRSYLS |
| SEQ ID NO：289 | CDR-L2 | SASTLQS |
| SEQ ID NO：290 | CDR-L3 | QQSYSTPLT |
抗Mac-1抗体CDR序列克隆：25B01
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：291 | CDR-H1 | GFTFSSYDVG |
| SEQ ID NO：292 | CDR-H2 | GIVPSGGNIYYADSVKG |
| SEQ ID NO：293 | CDR-H3 | HRSYAYYAFDY |
| SEQ ID NO：294 | CDR-L1 | RASQNVRNYLG |
| SEQ ID NO：295 | CDR-L2 | DASSLQS |
| SEQ ID NO：296 | CDR-L3 | QQYGDWPLT |
抗Mac-1抗体CDR序列克隆：DF3-10
抗Mac-1抗体CDR序列克隆：DF3-28
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：303 | CDR-H1 | GFTFTNYWMH |
| SEQ ID NO：304 | CDR-H2 | TIIYDGGETGYADSVKG |
| SEQ ID NO：305 | CDR-H3 | NSRKSGMDY |
| SEQ ID NO：306 | CDR-L1 | RASQSIYKYLN |
| SEQ ID NO：307 | CDR-L2 | DASTLQS |
| SEQ ID NO：308 | CDR-L3 | MQYYSDPLT |
抗Mac-1抗体CDR序列克隆：DF3-30
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：309 | CDR-H1 | GFTFSGYAWS |
| SEQ ID NO：310 | CDR-H2 | MISPAGGSTYYADSVKG |
| SEQ ID NO：311 | CDR-H3 | DRNAGGDSYYSFDV |
| SEQ ID NO：312 | CDR-L1 | RASQSINSHLA |
| SEQ ID NO：313 | CDR-L2 | AAINLQS |
| SEQ ID NO：314 | CDR-L3 | QQTNHYPLT |
抗Mac-1抗体CDR序列克隆：DF3-32
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：315 | CDR-H1 | GFTFSSHAMH |
| SEQ ID NO：316 | CDR-H2 | SILSGGSETNYADSVKG |
| SEQ ID NO：317 | CDR-H3 | DTYEVTGNLLDY |
| SEQ ID NO：318 | CDR-L1 | RASQSVWSYLN |
| SEQ ID NO：319 | CDR-L2 | GASSLQS |
| SEQ ID NO：320 | CDR-L3 | MQSYSWPFT |
抗Mac-1抗体CDR序列克隆：DF4-16
抗Mac-1抗体CDR序列克隆：DF4-17
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：327 | CDR-H1 | GFTFSDYGWH |
| SEQ ID NO：328 | CDR-H2 | IIESDGSGTYYADSVKG |
| SEQ ID NO：329 | CDR-H3 | NGEVGERGVRDYDYAMDY |
| SEQ ID NO：330 | CDR-L1 | RASQSINRYLN |
| SEQ ID NO：331 | CDR-L2 | ATSSLQS |
| SEQ ID NO：332 | CDR-L3 | QQYGSTPIT |
抗Mac-1抗体CDR序列克隆：DF4-22
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：333 | CDR-H1 | GFTFTDYNVH |
| SEQ ID NO：334 | CDR-H2 | GINSSGSETNYADSVKG |
| SEQ ID NO：335 | CDR-H3 | DSVFKTVGGYDAVMDY |
| SEQ ID NO：336 | CDR-L1 | RASQSIYNYLA |
| SEQ ID NO：337 | CDR-L2 | GTSTLQS |
| SEQ ID NO：338 | CDR-L3 | MQSYSSPTT |
抗Mac-1抗体CDR序列克隆：DF4-25
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：339 | CDR-H1 | GFTFKDYWLS |
| SEQ ID NO：340 | CDR-H2 | IINYGGSETYYADSVKG |
| SEQ ID NO：341 | CDR-H3 | TQTSYVMDY |
| SEQ ID NO：342 | CDR-L1 | RASQSVRSGLN |
| SEQ ID NO：343 | CDR-L2 | AASSLQS |
| SEQ ID NO：344 | CDR-L3 | MQSHSWPLT |
抗Mac-1抗体CDR序列克隆：DF4-26
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抗Mac-1抗体CDR序列克隆：DF4-42
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：351 | CDR-H1 | GFTFTDYQMS |
| SEQ ID NO：352 | CDR-H2 | TIIWSGSETNYADSVKG |
| SEQ ID NO：353 | CDR-H3 | NKTPFDY |
| SEQ ID NO：354 | CDR-L1 | RASQSIRTHLA |
| SEQ ID NO：355 | CDR-L2 | DNSNLQS |
| SEQ ID NO：356 | CDR-L3 | QQYKGSPLT |
抗Mac-1抗体CDR序列克隆：DF3M-1
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：357 | CDR-H1 | GFTFTSYAMS |
| SEQ ID NO：358 | CDR-H2 | SISYSGGETDYADSVKG |
| SEQ ID NO：359 | CDR-H3 | SKGGLYFDY |
| SEQ ID NO：360 | CDR-L1 | RASQSISSYLA |
| SEQ ID NO：361 | CDR-L2 | GASSLQS |
| SEQ ID NO：362 | CDR-L3 | QQYGSTPET |
抗Mac-1抗体CDR序列克隆：DF3M-2
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：363 | CDR-H1 | GFTFSGYWIH |
| SEQ ID NO：364 | CDR-H2 | TISYSGDEAYYADSVKG |
| SEQ ID NO：365 | CDR-H3 | SPSDGDYGFDY |
| SEQ ID NO：366 | CDR-L1 | RASQSINNYLS |
| SEQ ID NO：367 | CDR-L2 | DGRILQS |
| SEQ ID NO：368 | CDR-L3 | MQYLAYPWT |
抗Mac-1抗体序列克隆：DF3M-5(下划线是CDR序列)
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：369 | CDR-H1 | GFTFGTYDMH |
| SEQ ID NO：370 | CDR-H2 | MISPSGGDTYYADSVKG |
| SEQ ID NO：371 | CDR-H3 | DSSGDWYAMAY |
| SEQ ID NO：372 | CDR-L1 | RASQSIRRYLA |
| SEQ ID NO：373 | CDR-L2 | GASNLQS |
| SEQ ID NO：374 | CDR-L3 | QHSSDTPLT |
抗Mac-1抗体CDR序列克隆：DF3M-18
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：375 | CDR-H1 | GFTFSDSAMG |
| SEQ ID NO：376 | CDR-H2 | IISYYGSETYYADSVKG |
| SEQ ID NO：377 | CDR-H3 | NPDGDLSALDY |
| SEQ ID NO：378 | CDR-L1 | RASQPISSYLN |
| SEQ ID NO：379 | CDR-L2 | GASSLQS |
| SEQ ID NO：380 | CDR-L3 | QQRLRSPFT |
抗Mac-1抗体CDR序列克隆：DF3M-19
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：381 | CDR-H1 | GFTFTSYAMS |
| SEQ ID NO：382 | CDR-H2 | SINSGGSETNYADSVKG |
| SEQ ID NO：383 | CDR-H3 | GEYYTDVWPSGFDI |
| SEQ ID NO：384 | CDR-L1 | RASQSISNPLN |
| SEQ ID NO：385 | CDR-L2 | DASTLQS |
| SEQ ID NO：386 | CDR-L3 | QQYGSSPST |
抗Mac-1抗体CDR序列克隆：DF3M-30
抗Mac-1抗体CDR序列克隆：DF3M-36
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：393 | CDR-H1 | GFTFSDYGMS |
| SEQ ID NO：394 | CDR-H2 | IISPGGRETYYADSVKG |
| SEQ ID NO：395 | CDR-H3 | PDGGYYEFDV |
| SEQ ID NO：396 | CDR-L1 | RASQSISNYLA |
| SEQ ID NO：397 | CDR-L2 | DASTLQS |
| SEQ ID NO：398 | CDR-L3 | HQRNSWPPT |
抗Mac-1抗体CDR序列克隆：DF3M-42
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：399 | CDR-H1 | GFTFSSYHMH |
| SEQ ID NO：400 | CDR-H2 | AIDSSGRETFYADSVKG |
| SEQ ID NO：401 | CDR-H3 | GYGDYFDY |
| SEQ ID NO：402 | CDR-L1 | RASQSGSNYLA |
| SEQ ID NO：403 | CDR-L2 | AASTLQS |
| SEQ ID NO：404 | CDR-L3 | QQSGSTPYT |
抗Mac-1抗体CDR序列克隆：DF4M-1
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：405 | CDR-H1 | GFTFDNYVMG |
| SEQ ID NO：406 | CDR-H2 | MINYGGSETIYADSVKG |
| SEQ ID NO：407 | CDR-H3 | SACDYCDFDY |
| SEQ ID NO：408 | CDR-L1 | RASQVVGSYLN |
| SEQ ID NO：409 | CDR-L2 | GASTLQS |
| SEQ ID NO：410 | CDR-L3 | QQYYNYPGT |
抗Mac-1抗体CDR序列克隆：DF4M-3
抗Mac-1抗体CDR序列克隆：DF4M-7-1
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：417 | CDR-H1 | GFTFDSYAMH |
| SEQ ID NO：418 | CDR-H2 | SIDGSGRETDYADSVKG |
| SEQ ID NO：419 | CDR-H3 | DGSEGYAFDP |
| SEQ ID NO：420 | CDR-L1 | RASQIIRHKLN |
| SEQ ID NO：421 | CDR-L2 | DASTLQS |
| SEQ ID NO：422 | CDR-L3 | QQYNSWPIT |
抗Mac-1抗体CDR序列克隆：DF4M-7-4
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：423 | CDR-H1 | GFTFTSYIMS |
| SEQ ID NO：424 | CDR-H2 | IISYSGGETYYADSVKG |
| SEQ ID NO：425 | CDR-H3 | NGINDDSFDY |
| SEQ ID NO：426 | CDR-L1 | RASQSISNYLN |
| SEQ ID NO：427 | CDR-L2 | GASSLQS |
| SEQ ID NO：428 | CDR-L3 | QQRLHWPGT |
抗Mac-1抗体CDR序列克隆：DF4M-9
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：429 | CDR-H1 | GFTFTNHWMS |
| SEQ ID NO：430 | CDR-H2 | TIEGSGSETIYADSVKG |
| SEQ ID NO：431 | CDR-H3 | SSRTLFDY |
| SEQ ID NO：432 | CDR-L1 | RASQGVYSYLA |
| SEQ ID NO：433 | CDR-L2 | DASSLQS |
| SEQ ID NO：434 | CDR-L3 | QQYYHYPPT |
抗Mac-1抗体CDR序列克隆：DF4M-11
抗Mac-1抗体CDR序列克隆：DF4M-17
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：441 | CDR-H1 | GFTFSDYWVA |
| SEQ ID NO：442 | CDR-H2 | TISYSGSETEYADSVKG |
| SEQ ID NO：443 | CDR-H3 | YGGSDYYGFDP |
| SEQ ID NO：444 | CDR-L1 | RASQSISNNLA |
| SEQ ID NO：445 | CDR-L2 | ATTTLQS |
| SEQ ID NO：446 | CDR-L3 | MQSNTPWT |
抗Mac-1抗体CDR序列克隆：DF4M-18
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：447 | CDR-H1 | GFTFSSYAIS |
| SEQ ID NO：448 | CDR-H2 | AISSGGSETDYADSVKG |
| SEQ ID NO：449 | CDR-H3 | GESGYYMAEDV |
| SEQ ID NO：450 | CDR-L1 | RASQSVSSFLA |
| SEQ ID NO：451 | CDR-L2 | AASKLQS |
| SEQ ID NO：452 | CDR-L3 | QQYSVTPIT |
抗Mac-1抗体CDR序列克隆：DF4M-21
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：453 | CDR-H1 | GFTFSSYAMS |
| SEQ ID NO：454 | CDR-H2 | AISSYGGETDYADSVKG |
| SEQ ID NO：455 | CDR-H3 | GDAYSSFVDNPFDI |
| SEQ ID NO：456 | CDR-L1 | RASQSISNYLA |
| SEQ ID NO：457 | CDR-L2 | DASTLQS |
| SEQ ID NO：458 | CDR-L3 | MQYESTPWT |
抗Mac-1抗体CDR序列克隆：DF4M-23
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：459 | CDR-H1 | GFTFTSYAMS |
| SEQ ID NO：460 | CDR-H2 | AISPSGSETEYADSVKG |
| SEQ ID NO：461 | CDR-H3 | GFYNDYIFDL |
| SEQ ID NO：462 | CDR-L1 | RASQSISSYLN |
| SEQ ID NO：463 | CDR-L2 | AASSLQS |
| SEQ ID NO：464 | CDR-L3 | QQYLSTPYT |
抗Mac-1抗体CDR序列克隆：DF4M-30
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：465 | CDR-H1 | GFTFRNNAMH |
| SEQ ID NO：466 | CDR-H2 | VINSGGSETYYADSVKG |
| SEQ ID NO：467 | CDR-H3 | DEPSDEYGMYGFDY |
| SEQ ID NO：468 | CDR-L1 | RASQSISSYLN |
| SEQ ID NO：469 | CDR-L2 | KASNLQS |
| SEQ ID NO：470 | CDR-L3 | VQYSRSPTT |
抗Mac-1抗体CDR序列克隆：DF4M-31
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：471 | CDR-H1 | GFTFTSATMS |
| SEQ ID NO：472 | CDR-H2 | IISPGGSETYYADSVKG |
| SEQ ID NO：473 | CDR-H3 | GGDYPSYYMDP |
| SEQ ID NO：474 | CDR-L1 | RASQSISNYLA |
| SEQ ID NO：475 | CDR-L2 | GTSSLQS |
| SEQ ID NO：476 | CDR-L3 | QQGHQWPWT |
抗Mac-1抗体CDR序列克隆：DF4M-45
/>
抗Mac-1抗体CDR序列克隆：28E07、28E07-HH、28E07-B1H、28E07-B2H、28E07-B3H、28E07-B4H、28E07-HB1、28E07-HB2、28E07-HB3、28E07-HB4、28E07-B1B1、28E07-B1B2、28E07-B2B1和28E07-B2B2
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：483 | CDR-H1 | GYSFTDYNMN |
| SEQ ID NO：484 | CDR-H2 | EINPGYGTSRYNQKFKD |
| SEQ ID NO：485 | CDR-H3 | ADVDYGDVMDY |
| SEQ ID NO：486 | CDR-L1 | SASSSVSYMH |
| SEQ ID NO：487 | CDR-L2 | DTSKLAS |
| SEQ ID NO：488 | CDR-L3 | QQWSSNPPT |
抗Mac-1抗体CDR序列克隆：28A12
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：489 | CDR-H1 | GYSFTDYNMN |
| SEQ ID NO：490 | CDR-H2 | EINPGYGTSRYNQKFKD |
| SEQ ID NO：491 | CDR-H3 | ADVDYGDTMDY |
| SEQ ID NO：492 | CDR-L1 | SASSSVSDMH |
| SEQ ID NO：493 | CDR-L2 | DTSKLAS |
| SEQ ID NO：494 | CDR-L3 | QQWSSNPPT |
抗Mac-1抗体CDR序列克隆：27G04
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：495 | CDR-H1 | GYSFTDYNMN |
| SEQ ID NO：496 | CDR-H2 | VINPNYGTTSYNQKFKG |
| SEQ ID NO：497 | CDR-H3 | TFDYDDDAFAY |
| SEQ ID NO：498 | CDR-L1 | SASSSVSDMH |
| SEQ ID NO：499 | CDR-L2 | DTSKLAS |
| SEQ ID NO：500 | CDR-L3 | QQWSSNPPT |
抗Mac-1抗体CDR序列克隆：27A04
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抗Mac-1抗体CDR序列克隆：27A06
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：507 | CDR-H1 | GYSFTDYNMN |
| SEQ ID NO：508 | CDR-H2 | EINPNYGTTRHNQKFKG |
| SEQ ID NO：509 | CDR-H3 | TYDYDEDAFAY |
| SEQ ID NO：510 | CDR-L1 | SASSSVSYMH |
| SEQ ID NO：511 | CDR-L2 | DTSKLAS |
| SEQ ID NO：512 | CDR-L3 | QQWSSNPPT |
抗Mac-1抗体CDR序列克隆：28G06
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：513 | CDR-H1 | GYSFTDYNMN |
| SEQ ID NO：514 | CDR-H2 | IINPNYGTTSYNQKFKG |
| SEQ ID NO：515 | CDR-H3 | GYDYDESGFAY |
| SEQ ID NO：516 | CDR-L1 | SASSSVSYMY |
| SEQ ID NO：517 | CDR-L2 | DTSNLAS |
| SEQ ID NO：518 | CDR-L3 | QQWSSNPPT |
抗Mac-1抗体CDR序列克隆：27B10
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：519 | CDR-H1 | GYSFTDYNMN |
| SEQ ID NO：520 | CDR-H2 | RINPNFGTTTYNQKFKG |
| SEQ ID NO：521 | CDR-H3 | GYDYDESGFAY |
| SEQ ID NO：522 | CDR-L1 | SASSSVSYMY |
| SEQ ID NO：523 | CDR-L2 | DTSNLAS |
| SEQ ID NO：524 | CDR-L3 | QQWSSYPPT |
抗Mac-1抗体CDR序列克隆：27D06
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：525 | CDR-H1 | GYSFTDYNMN |
| SEQ ID NO：526 | CDR-H2 | VINPNYGTTSYNQKFKG |
| SEQ ID NO：527 | CDR-H3 | TYDYDGDAFAY |
| SEQ ID NO:528 | CDR-L1 | RASSSVSSNNLH |
| SEQ ID NO:529 | CDR-L2 | STSNLAT |
| SEQ ID NO：530 | CDR-L3 | QQWNSNPPT |
抗Mac-1抗体CDR序列克隆：28D06
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：531 | CDR-H1 | GYSFTDYNMN |
| SEQ ID NO：532 | CDR-H2 | EINPNYGTTRYNQKFKG |
| SEQ ID NO：533 | CDR-H3 | PSIYYDYDDAMDY |
| SEQ ID NO：534 | CDR-L1 | SASSSVNYMY |
| SEQ ID NO：535 | CDR-L2 | DTSNLAS |
| SEQ ID NO：536 | CDR-L3 | QQWITYPPTLT |
抗Mac-1抗体CDR序列克隆：27E12
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：537 | CDR-H1 | GYTFTSYWMH |
| SEQ ID NO：538 | CDR-H2 | AIYPGNSDTSYNQKFKGKA |
| SEQ ID NO：539 | CDR-H3 | GSYEFAY |
| SEQ ID NO：540 | CDR-L1 | SVSSSVSYMY |
| SEQ ID NO：541 | CDR-L2 | DTSNLAS |
| SEQ ID NO：542 | CDR-L3 | QQWSSNPFT |
抗Mac-1抗体CDR序列克隆：m2396
抗Mac-1抗体CDR序列克隆：H4L2
| SEQ ID编号 | 描述 | 序列 |
| SEQ ID NO：549 | CDR-H1 | NYWIN |
| SEQ ID NO：550 | CDR-H2 | NIYPSDTYINHNQKFKD |
| SEQ ID NO：551 | CDR-H3 | SAYANYFDY |
| SEQ ID NO：552 | CDR-L1 | RASQNIGTSIH |
| SEQ ID NO：553 | CDR-L2 | YASESIS |
| SEQ ID NO：554 | CDR-L3 | QQSDSWPTLT |
序列表
<110> 先知生物科技股份有限公司
<120> 抗人MAC-1的单克隆抗体及其用途
<130> IMD08PCT
<150> US 63/131,893
<151> 2020-12-30
<160> 380
<170> PatentIn version 3.5
<210> 1
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Asn Tyr Ser Gly Arg Glu Ala Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gly Ser Tyr Val Gly Gln Ala His Glu Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 2
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Asn Tyr Ser Gly Arg Glu Ala Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gly Ser Tyr Val Gly Gln Ala His Glu Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 3
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Tyr Trp Ser Gly Ser Glu Ile Asn Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Phe Ala Ser Gly Glu Ser Ala Met Asp Val Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 4
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 4
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ser Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 5
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser
20 25 30
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Asn Ser Gly Gly Gly Glu Ala Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Asp Ala Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 6
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 6
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Leu Ile Arg Lys Lys
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Ser Gly Ser Pro Gln Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 7
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr
20 25 30
Trp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Ile Ser Asp Gly Gly Glu Ile Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ile His Ala Gly Thr Gly Ser Ser Ala Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 8
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Tyr Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 9
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Tyr Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 10
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Tyr Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ile Leu Gln Tyr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Ser Asn Ser Ser Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105
<210> 11
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Tyr Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ile Leu Gln Tyr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Ser Asn Ser Ser Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105
<210> 12
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Leu Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Met Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Tyr Tyr His Trp Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 13
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 13
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Ile Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Pro Ser Gly Ser Glu Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Ala Trp Asp Asn Asn Trp Val Arg Glu Tyr Gly Met Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 14
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 14
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Gly Asn Asn Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Ser Asn Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 15
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 15
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Gly Asn Asn Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Ser Asn Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 16
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asp Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ile Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Leu Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 17
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Tyr Trp Ser Gly Ser Asn Ala Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Phe Thr Leu Gly Tyr His Gly Phe Asp Val Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 18
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 18
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Thr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asp Leu Pro Phe
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 19
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn
20 25 30
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Asn Tyr Ser Gly Arg Glu Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Asp Tyr Asn Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 20
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 20
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Asn Ser Ser His
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Val Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Gly Ser Thr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 21
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 21
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Ser Tyr Gly Gly Gly Glu Ala Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Met Ala Ser Glu Tyr Gly Pro Trp Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 22
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 22
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg His
20 25 30
Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Asp Trp Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 23
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 23
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Asp
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Asn Tyr Asp Gly Ser Trp Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Ser Ser Ile Asp Glu Pro Pro Tyr Gly Pro Phe Asp Val
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 24
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 24
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Glu Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Phe Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 25
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 25
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Tyr Tyr Asp Gly Ser Glu Ala Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Lys Asp Ile Tyr Ser Val Tyr Gly Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 26
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Asn Thr Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 27
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 27
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Val Tyr Gly Gly Ser Glu Ile Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Pro Gly Tyr Ser Gly Thr Pro Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 28
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 28
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Arg Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Phe Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 29
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Asp Ser
20 25 30
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Ser Tyr Ser Gly Gly Glu Ala Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ser Gly Gly Ser Ala Met Gly Phe Asp Ile Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 30
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 30
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile His Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Arg Phe Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 31
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 31
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Trp
20 25 30
Tyr Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Asn Gly Gly Gly Ser Glu Ile Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Asp Gly Asp Gly Ser Gly Phe Asp Asp Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 32
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 32
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile His Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Met Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Gly Asn Tyr Pro Phe
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 33
<211> 125
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 33
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Thr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ile Tyr Asn Gly Ser Glu Ala Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asn Asp Tyr Asp His Gly Cys Cys Asp Asn Tyr Ala Met
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 34
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 34
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Tyr
20 25 30
Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln His Gly Gly Trp Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 35
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 35
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Tyr
20 25 30
Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln His Gly Gly Trp Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 36
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 36
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Asn Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Trp Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 37
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 37
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Trp
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Tyr Gly Gly Ser Glu Ala Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Ser Ser Asp Arg Leu Leu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 38
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 38
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Lys Ser Ser
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Thr Asn Arg His Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 39
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 39
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Asn Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Tyr Ser Gly Ser Glu Ile Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Asp Glu Tyr Thr Tyr Tyr Tyr Phe Asp Pro Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 40
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 40
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Lys Gln Ser Tyr Ser Ser Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 41
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ile Gly Gly Gly Ser Glu Ala Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Ser Tyr Gly Tyr Leu Gly Phe Asp Ile Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 42
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 42
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Asn Ser
20 25 30
Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ser Ala Gly Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Phe Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 43
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Asn
20 25 30
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Met Ile Ser Tyr Ser Gly Gly Glu Ala Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Trp Leu Pro Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 44
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 44
Asp Ile Gln Met Thr Gln Ser Pro Gly Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 45
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 45
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Val Pro Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg His Arg Ser Tyr Ala Tyr Tyr Ala Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 46
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 46
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Arg Asn Tyr
20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Asp Trp Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 47
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Ala
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Ser Tyr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Arg Tyr Ile Glu Ser Pro Val Tyr Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 48
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ala Lys Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Glu Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ser Ser Ser Pro Glu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 49
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 49
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr
20 25 30
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ile Tyr Asp Gly Gly Glu Thr Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Ser Arg Lys Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 50
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 50
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Tyr Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Tyr Tyr Ser Asp Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 51
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 51
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr
20 25 30
Ala Trp Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Met Ile Ser Pro Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Asn Ala Gly Gly Asp Ser Tyr Tyr Ser Phe Asp Val
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 52
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 52
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser His
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ile Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn His Tyr Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 53
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 53
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Leu Ser Gly Gly Ser Glu Thr Asn Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Thr Tyr Glu Val Thr Gly Asn Leu Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 54
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 54
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Trp Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Ser Tyr Ser Trp Pro Phe
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 55
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 55
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Glu Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ile Pro Asp Gly Ser Glu Thr Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Leu Ser Ser Ser Gly Met His Gly Asp Ile Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 56
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 56
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr His Ser Pro Tyr Thr
85 90 95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 57
<211> 127
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 57
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Gly Trp His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Glu Ser Asp Gly Ser Gly Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Gly Glu Val Gly Glu Arg Gly Val Arg Asp Tyr Asp Tyr
100 105 110
Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 58
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 58
Asp Ile Gln Met Thr Gln Ser Pro Arg Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Arg Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Thr Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 59
<211> 125
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 59
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr
20 25 30
Asn Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Asn Ser Ser Gly Ser Glu Thr Asn Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ser Val Phe Lys Thr Val Gly Gly Tyr Asp Ala Val Met
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 60
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 60
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Tyr Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Ser Tyr Ser Ser Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 61
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Asp Tyr
20 25 30
Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Asn Tyr Gly Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Gln Thr Ser Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 62
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 62
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Arg Ser Gly
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Arg Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Ser His Ser Trp Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 63
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 63
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Gly
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Gly Ser Gly Arg Glu Thr Asn Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ala Trp Gly Gly Asp Ser Tyr Phe Asp Pro Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 64
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 64
Asp Ile Gln Met Thr Gln Ser Pro Gly Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Trp Ser Asn
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asn Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Gly Thr Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 65
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 65
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr
20 25 30
Gln Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ile Trp Ser Gly Ser Glu Thr Asn Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Lys Thr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 66
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 66
Asp Ile Gln Met Thr Gln Ser Pro Arg Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Thr His
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Asn Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Gly Ser Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 67
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 67
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Tyr Ser Gly Gly Glu Thr Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Lys Gly Gly Leu Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 68
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 68
Asp Ile Gln Met Thr Gln Ser Pro Gly Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Thr Pro Glu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 69
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 69
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr
20 25 30
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Tyr Ser Gly Asp Glu Ala Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Pro Ser Asp Gly Asp Tyr Gly Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 70
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 70
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Asn Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Asn Tyr
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Gly Arg Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Tyr Leu Ala Tyr Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 71
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 71
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Tyr
20 25 30
Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Met Ile Ser Pro Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ser Ser Gly Asp Trp Tyr Ala Met Ala Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 72
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 72
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Arg Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Ser Asp Thr Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 73
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 73
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
20 25 30
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Ser Tyr Tyr Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Pro Asp Gly Asp Leu Ser Ala Leu Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 74
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 74
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Leu Arg Ser Pro Phe
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 75
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 75
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asn Ser Gly Gly Ser Glu Thr Asn Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Glu Tyr Tyr Thr Asp Val Trp Pro Ser Gly Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 76
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 76
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Pro
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 77
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 77
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Glu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Ser Trp Ser Gly Ser Glu Thr Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Gly Arg Gly Asp Tyr Ala Phe Asp Phe Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 78
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 78
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Asn Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Arg Thr Thr Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Tyr Gly Ser Leu Pro Ser
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 79
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 79
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Ser Pro Gly Gly Arg Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Pro Asp Gly Gly Tyr Tyr Glu Phe Asp Val Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 80
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 80
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser Trp Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 81
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 81
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
His Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Asp Ser Ser Gly Arg Glu Thr Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Tyr Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 82
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 82
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
His Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Asp Ser Ser Gly Arg Glu Thr Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Tyr Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 83
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 83
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Tyr
20 25 30
Val Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Met Ile Asn Tyr Gly Gly Ser Glu Thr Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ala Cys Asp Tyr Cys Asp Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 84
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 84
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Val Val Gly Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 85
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 85
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Thr Tyr
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ile Pro Ser Gly Ser Glu Thr Asn Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Pro Ala Ala Ser Glu Gly Pro Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 86
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 86
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr His Ser Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 87
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 87
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asp Gly Ser Gly Arg Glu Thr Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gly Ser Glu Gly Tyr Ala Phe Asp Pro Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 88
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 88
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ile Ile Arg His Lys
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Pro Ile
85 90 95
Thr Phe Gly Gln Gly Ala Lys Val Glu Ile Lys
100 105
<210> 89
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 89
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
20 25 30
Ile Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Ser Tyr Ser Gly Gly Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Gly Ile Asn Asp Asp Ser Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 90
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 90
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Leu His Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 91
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 91
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn His
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Glu Gly Ser Gly Ser Glu Thr Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ser Arg Thr Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 92
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 92
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Tyr Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr His Tyr Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 93
<211> 122
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 93
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asn Pro Trp Gly Gly Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Ile Thr Ser Lys Tyr Glu Asp Tyr Ala Met Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 94
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 94
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Ala Gln Asn Pro Phe
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 95
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 95
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Trp Val Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Tyr Ser Gly Ser Glu Thr Glu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Tyr Gly Gly Ser Asp Tyr Tyr Gly Phe Asp Pro Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 96
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 96
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Thr Thr Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Ser Asn Thr Pro Trp Thr
85 90 95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 97
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 97
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Ser Gly Gly Ser Glu Thr Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Glu Ser Gly Tyr Tyr Met Ala Glu Asp Val Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 98
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 98
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Val Thr Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 99
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 99
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Ser Tyr Gly Gly Glu Thr Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Asp Ala Tyr Ser Ser Phe Val Asp Asn Pro Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 100
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 100
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Tyr Glu Ser Thr Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 101
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 101
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Pro Ser Gly Ser Glu Thr Glu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Phe Tyr Asn Asp Tyr Ile Phe Asp Leu Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 102
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 102
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Ser Thr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 103
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 103
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Asn
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Asn Ser Gly Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Glu Pro Ser Asp Glu Tyr Gly Met Tyr Gly Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 104
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 104
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Tyr Ser Arg Ser Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 105
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 105
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Ala
20 25 30
Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Ser Pro Gly Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Asp Tyr Pro Ser Tyr Tyr Met Asp Pro Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 106
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 106
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Gln Trp Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 107
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 107
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ile Ser Asp Gly Ser Glu Thr Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Asn Arg Tyr Gly Phe Gln Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 108
<211> 107
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 108
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ala Arg Asn Gly
20 25 30
Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Tyr Ser Tyr Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 109
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 109
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Thr Thr Ala Tyr
65 70 75 80
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 110
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 110
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Thr Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 111
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 111
Gln Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Thr Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 112
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 112
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Asp Met
20 25 30
His Trp Tyr Gln Gln Lys Ser Gly Asn Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 113
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 113
Gln Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Asn Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Phe Asp Tyr Asp Asp Asp Ala Phe Ala Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 114
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 114
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Asp Met
20 25 30
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 115
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 115
Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Asn Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Tyr Asp Tyr Asp Gly Asp Ala Phe Ala Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 116
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 116
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 117
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 117
Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Thr Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Pro Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Asn Tyr Gly Thr Thr Arg His Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Ser Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Tyr Asp Tyr Asp Glu Asp Ala Phe Ala Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 118
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 118
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Ser Asp Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 119
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 119
Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Ile Ile Asn Pro Asn Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Tyr Asp Tyr Asp Glu Ser Gly Phe Ala Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 120
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 120
Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Ile Ile Asn Pro Asn Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Tyr Asp Tyr Asp Glu Ser Gly Phe Ala Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 121
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 121
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asn Pro Asn Phe Gly Thr Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Tyr Asp Tyr Asp Glu Ser Gly Phe Ala Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 122
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 122
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 123
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 123
Gln Val Lys Leu Gln Glu Ser Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Asn Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Tyr Asp Tyr Asp Gly Asp Ala Phe Ala Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 124
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 124
Asp Ile Glu Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Asn
20 25 30
Asn Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Thr Gly Ala Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Asn Pro
85 90 95
Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 125
<211> 122
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 125
Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Asn Tyr Gly Thr Thr Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Ser Ile Tyr Tyr Asp Tyr Asp Asp Ala Met Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 126
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 126
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Asn Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Thr Tyr Pro Pro Thr
85 90 95
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 127
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 127
Gln Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Gly Gly Gly Ser Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 128
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 128
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
85 90 95
Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 129
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 129
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn
20 25 30
Ser Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ala Ile Trp Ser Gly Gly Gly Thr Asp Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Ile Tyr Phe Cys Thr
85 90 95
Arg Gly Gly Tyr Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Val Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 130
<211> 113
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 130
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
20 25 30
Glu Asn Gln Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Asp Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 131
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 131
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Asn Ile Tyr Pro Ser Asp Thr Tyr Ile Asn His Asn Gln Lys Phe
50 55 60
Lys Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ala Tyr Ala Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 132
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 132
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Gly Thr Ser
20 25 30
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asp Ser Trp Pro Thr
85 90 95
Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 133
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 133
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 134
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 134
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65 70 75 80
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 135
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 135
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Arg Val Thr Leu Thr Val Asp Gln Ser Ile Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 136
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 136
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65 70 75 80
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 137
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 137
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Gln Ser Ile Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 138
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 138
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65 70 75 80
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 139
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 139
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Gln Ser Ile Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 140
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 140
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65 70 75 80
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 141
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 141
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ala Asn Gly Gln Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Gln Ser Ile Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 142
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 142
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65 70 75 80
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 143
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 143
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 144
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 144
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Arg Leu Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65 70 75 80
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 145
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 145
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 146
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 146
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65 70 75 80
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 147
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 147
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 148
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 148
Glu Ile Glu Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly
1 5 10 15
Glu Arg Val Thr Met Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Met Glu Pro Glu
65 70 75 80
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 149
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 149
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 150
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 150
Glu Ile Glu Leu Thr Gln Ser Pro Ala Thr Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Arg Val Thr Met Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Met Glu Pro Glu
65 70 75 80
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 151
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 151
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Arg Val Thr Leu Thr Val Asp Gln Ser Ile Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 152
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 152
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Arg Leu Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65 70 75 80
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 153
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 153
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Arg Val Thr Leu Thr Val Asp Gln Ser Ile Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 154
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 154
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65 70 75 80
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 155
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 155
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Gln Ser Ile Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 156
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 156
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Arg Leu Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65 70 75 80
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 157
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 157
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Gly Tyr Gly Thr Ser Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Gln Ser Ile Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Val Asp Tyr Gly Asp Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 158
<211> 106
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 158
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65 70 75 80
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 159
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 159
Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser
1 5 10
<210> 160
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 160
Ile Ile Asn Tyr Ser Gly Arg Glu Ala Asp Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 161
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 161
Asp Gly Ser Tyr Val Gly Gln Ala His Glu Ala Phe Asp Ile
1 5 10
<210> 162
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 162
Arg Ala Ser Gln Ser Ile Ser Lys Tyr Leu Ala
1 5 10
<210> 163
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 163
Gly Thr Ser Asn Leu Gln Ser
1 5
<210> 164
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 164
Gln Gln Ser Arg Ser Trp Pro Leu Thr
1 5
<210> 165
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 165
Gly Phe Thr Phe Ser Ser Ala Trp Met Ser
1 5 10
<210> 166
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 166
Thr Ile Tyr Trp Ser Gly Ser Glu Ile Asn Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 167
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 167
Ser Phe Ala Ser Gly Glu Ser Ala Met Asp Val
1 5 10
<210> 168
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 168
Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala
1 5 10
<210> 169
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 169
Asp Ala Ser Asn Leu Gln Ser
1 5
<210> 170
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 170
Asp Ala Ser Asn Leu Gln Ser
1 5
<210> 171
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 171
Gly Phe Thr Phe Ser Thr Ser Trp Met His Trp
1 5 10
<210> 172
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 172
Gly Phe Thr Phe Ser Thr Ser Trp Met His Trp
1 5 10
<210> 173
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 173
Gly Asp Ala Ala Phe Asp Tyr
1 5
<210> 174
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 174
Arg Ala Ser Gln Leu Ile Arg Lys Lys Leu Ala
1 5 10
<210> 175
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 175
Ala Ala Ser Thr Leu Gln Ser
1 5
<210> 176
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 176
Met Gln Ser Gly Ser Pro Gln Tyr Thr
1 5
<210> 177
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 177
Gly Phe Thr Phe Thr Asn Tyr Trp Met Gly
1 5 10
<210> 178
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 178
Ile Ile Ile Ser Asp Gly Gly Glu Ile Ile Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 179
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 179
Ile His Ala Gly Thr Gly Ser Ser Ala Asp Tyr
1 5 10
<210> 180
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 180
Arg Ala Ser Gln Ser Ile Tyr Asn Tyr Leu Asn
1 5 10
<210> 181
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 181
Asp Ala Ser Thr Leu Gln Ser
1 5
<210> 182
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 182
Gln Gln Tyr Tyr Ser Tyr Pro Trp Thr
1 5
<210> 183
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 183
Gly Phe Thr Phe Arg Thr Phe Gly Met Asn
1 5 10
<210> 184
<211> 18
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 184
Gly Ile Val Pro Ser Gly Ser Glu Ile Asp Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly Arg
<210> 185
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 185
Asp His Ser His Tyr Thr Gly Pro Phe Asp Val
1 5 10
<210> 186
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 186
Arg Ala Ser Gln Ser Ile Tyr Ser Tyr Leu Asn
1 5 10
<210> 187
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 187
Gly Ala Ser Ile Leu Gln Tyr
1 5
<210> 188
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 188
Gly Ala Ser Ile Leu Gln Tyr
1 5
<210> 189
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 189
Gly Phe Thr Phe Thr Ser Tyr Trp Met Thr
1 5 10
<210> 190
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 190
Thr Ile Val Gly Gly Gly Gly Glu Ala Asp Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 191
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 191
Asp Tyr Val Ala Asp Asn His Gly Ala Met Asp Tyr
1 5 10
<210> 192
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 192
Arg Ala Ser Gln Gly Leu Ser Ser Tyr Leu Asn
1 5 10
<210> 193
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 193
Gly Met Ser Thr Leu Gln Ser
1 5
<210> 194
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 194
Met Gln Tyr Tyr His Trp Pro Tyr Thr
1 5
<210> 195
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 195
Gly Phe Thr Phe Ser Asp Tyr Ile Met His
1 5 10
<210> 196
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 196
Ala Ile Ser Pro Ser Gly Ser Glu Ile Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 197
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 197
Asn Ala Trp Asp Asn Asn Trp Val Arg Glu Tyr Gly Met Asp Tyr
1 5 10 15
<210> 198
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 198
Arg Ala Ser Gln Ser Gly Asn Asn Asn Leu Ala
1 5 10
<210> 199
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 199
Gly Ala Ser Thr Leu Gln Ser
1 5
<210> 200
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 200
Met Gln Ser Asn Ser Tyr Pro Leu Thr
1 5
<210> 201
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 201
Met Gln Ser Asn Ser Tyr Pro Leu Thr
1 5
<210> 202
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 202
Ile Tyr Ala Asp Ser Val Lys Gly
1 5
<210> 203
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 203
Ser Ser Tyr Gly Glu Gly Tyr Ala Phe Asp Tyr
1 5 10
<210> 204
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 204
Arg Ala Ser Gln Asp Val Asp Ser Tyr Leu Asn
1 5 10
<210> 205
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 205
Asp Ala Ile Ser Leu Gln Ser
1 5
<210> 206
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 206
Gln Gln Tyr Tyr Ser Leu Pro Leu Thr
1 5
<210> 207
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 207
Gly Phe Thr Phe Ser Asp Tyr Ala Ile Gly
1 5 10
<210> 208
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 208
Thr Ile Tyr Trp Ser Gly Ser Asn Ala Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 209
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 209
Leu Phe Thr Leu Gly Tyr His Gly Phe Asp Val
1 5 10
<210> 210
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 210
Arg Ala Ser Gln Ser Ile Asn Thr Tyr Leu Asn
1 5 10
<210> 211
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 211
Asp Ala Ser Asn Leu Gln Ser
1 5
<210> 212
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 212
Gln Gln Tyr Asp Asp Leu Pro Phe Thr
1 5
<210> 213
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 213
Ser Gly Phe Thr Phe Ser Ser Asn Ser Met Ser
1 5 10
<210> 214
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 214
Ala Ile Asn Tyr Ser Gly Arg Glu Ile Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 215
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 215
Thr Asp Tyr Asn Thr Phe Asp Tyr
1 5
<210> 216
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 216
Arg Ala Ser Gln Ser Asn Ser Ser His Leu Asn
1 5 10
<210> 217
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 217
Gly Val Ser Asn Leu Gln Ser
1 5
<210> 218
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 218
Gln His Tyr Gly Ser Thr Pro Tyr Thr
1 5
<210> 219
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 219
Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser
1 5 10
<210> 220
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 220
Val Ile Ser Tyr Gly Gly Gly Glu Ala Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 221
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 221
Ala Met Ala Ser Glu Tyr Gly Pro Trp Asp Tyr
1 5 10
<210> 222
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 222
Arg Ala Ser Gln Ser Ile Ser Arg His Leu Thr
1 5 10
<210> 223
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 223
Gly Ala Ser Thr Leu Gln Ser
1 5
<210> 224
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 224
Gln Gln Tyr His Asp Trp Pro Leu Thr
1 5
<210> 225
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 225
Gly Phe Thr Phe Gly Asp Asp Tyr Met His
1 5 10
<210> 226
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 226
Ala Ile Asn Tyr Asp Gly Ser Trp Lys Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 227
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 227
Leu Ser Ser Ile Asp Glu Pro Pro Tyr Gly Pro Phe Asp Val
1 5 10
<210> 228
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 228
Arg Ala Ser Gln Ser Ile Ser Thr Tyr Leu Ala
1 5 10
<210> 229
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 229
Glu Ala Ser Ser Leu Gln Ser
1 5
<210> 230
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 230
Gln Gln Tyr Tyr Asn Phe Pro Pro Thr
1 5
<210> 231
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 231
Gly Phe Thr Phe Asn Asn Tyr Tyr Met Ser
1 5 10
<210> 232
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 232
Ile Ile Tyr Tyr Asp Gly Ser Glu Ala Asp Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 233
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 233
Asn Lys Asp Ile Tyr Ser Val Tyr Gly Met Asp Tyr
1 5 10
<210> 234
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 234
Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala
1 5 10
<210> 235
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 235
Ala Thr Ser Asn Leu Gln Ser
1 5
<210> 236
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 236
Gln Gln Ala Asn Asn Thr Pro Pro Thr
1 5
<210> 237
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 237
Gly Phe Thr Phe Ser Asp Tyr Trp Met Ser
1 5 10
<210> 238
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 238
Ser Ile Val Tyr Gly Gly Ser Glu Ile Asp Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 239
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 239
Val Pro Gly Tyr Ser Gly Thr Pro Phe Asp Tyr
1 5 10
<210> 240
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 240
Arg Ala Ser Gln Ser Val Ser Arg Tyr Leu Ala
1 5 10
<210> 241
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 241
Asp Thr Ser Ser Leu Gln Ser
1 5
<210> 242
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 242
Gln Gln Ser Tyr Ser Phe Pro Leu Thr
1 5
<210> 243
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 243
Gly Phe Thr Phe Lys Asp Ser Trp Met His
1 5 10
<210> 244
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 244
Ile Ile Ser Tyr Ser Gly Gly Glu Ala Ile Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 245
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 245
Asp Ser Gly Gly Ser Ala Met Gly Phe Asp Ile
1 5 10
<210> 246
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 246
Arg Ala Ser Gln Ser Ile His Ser Tyr Leu Asn
1 5 10
<210> 247
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 247
Gly Ala Ser Ser Leu Gln Ser
1 5
<210> 248
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 248
Gln Gln Tyr Tyr Arg Phe Pro Tyr Thr
1 5
<210> 249
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 249
Gly Phe Thr Phe Ser Asp Trp Tyr Leu His
1 5 10
<210> 250
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 250
Val Ile Asn Gly Gly Gly Ser Glu Ile Ile Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 251
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 251
Gly Gly Asp Gly Asp Gly Ser Gly Phe Asp Asp
1 5 10
<210> 252
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 252
Arg Ala Ser Gln Ser Ile His Ser Tyr Leu Asn
1 5 10
<210> 253
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 253
Asp Ala Ser Asn Leu Gln Ser
1 5
<210> 254
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 254
Gln Gln Ser Gly Asn Tyr Pro Phe Thr
1 5
<210> 255
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 255
Gly Phe Thr Phe Ser Phe Thr Ala Met His
1 5 10
<210> 256
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 256
Ala Ile Ile Tyr Asn Gly Ser Glu Ala Asp Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 257
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 257
Ala Asn Asp Tyr Asp His Gly Cys Cys Asp Asn Tyr Ala Met Asp Tyr
1 5 10 15
<210> 258
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 258
Arg Ala Ser Gln Gly Ile Gly Ser Tyr Leu Tyr
1 5 10
<210> 259
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 259
Asp Ala Ser Asn Leu Gln Ser
1 5
<210> 260
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 260
Met Gln His Gly Gly Trp Pro Leu Thr
1 5
<210> 261
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 261
Gly Phe Thr Phe Ser Ser Tyr Tyr Met Ser
1 5 10
<210> 262
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 262
Thr Ile Asn Tyr Asp Gly Ser Glu Lys Asp Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 263
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 263
Asp Arg Leu Gly Asn Tyr Pro Trp Phe Asp Val
1 5 10
<210> 264
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 264
Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala
1 5 10
<210> 265
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 265
Asp Ala Asn Asn Leu Gln Ser
1 5
<210> 266
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 266
Gln Gln Ser Tyr Ser Trp Pro Leu Thr
1 5
<210> 267
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 267
Gly Phe Thr Phe Thr Glu Trp Trp Met Ser
1 5 10
<210> 268
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 268
Thr Ile Ser Tyr Gly Gly Ser Glu Ala Ile Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 269
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 269
Thr Ser Ser Asp Arg Leu Leu Phe Asp Tyr
1 5 10
<210> 270
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 270
Arg Ala Ser Gln Ser Ile Lys Ser Ser Leu Ala
1 5 10
<210> 271
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 271
Gly Ala Ser Thr Leu Gln Ser
1 5
<210> 272
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 272
Met Gln Thr Asn Arg His Pro Trp Thr
1 5
<210> 273
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 273
Gly Phe Thr Phe Ser Asn Tyr Asn Leu His
1 5 10
<210> 274
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 274
Thr Ile Ser Tyr Ser Gly Ser Glu Ile Ile Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 275
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 275
Glu Asp Glu Tyr Thr Tyr Tyr Tyr Phe Asp Pro
1 5 10
<210> 276
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 276
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala
1 5 10
<210> 277
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 277
Asp Ala Ser Lys Leu Gln Ser
1 5
<210> 278
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 278
Lys Gln Ser Tyr Ser Ser Pro Pro Thr
1 5
<210> 279
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 279
Gly Phe Thr Phe Ser Asp Tyr Trp Met His
1 5 10
<210> 280
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 280
Thr Ile Ile Gly Gly Gly Ser Glu Ala Gly Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 281
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 281
Asp Arg Ser Tyr Gly Tyr Leu Gly Phe Asp Ile
1 5 10
<210> 282
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 282
Arg Ala Ser Gln Ser Ile Arg Asn Ser Leu His
1 5 10
<210> 283
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 283
Ser Ala Gly Lys Leu Gln Ser
1 5
<210> 284
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 284
Gln Gln Ser Asn Ser Phe Pro Leu Thr
1 5
<210> 285
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 285
Gly Phe Thr Phe Ser Thr Asn Trp Met His
1 5 10
<210> 286
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 286
Met Ile Ser Tyr Ser Gly Gly Glu Ala Ile Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 287
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 287
Asn Trp Leu Pro Tyr Ala Met Asp Tyr
1 5
<210> 288
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 288
Arg Ala Ser Gln Ser Ile Arg Ser Tyr Leu Ser
1 5 10
<210> 289
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 289
Ser Ala Ser Thr Leu Gln Ser
1 5
<210> 290
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 290
Gln Gln Ser Tyr Ser Thr Pro Leu Thr
1 5
<210> 291
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 291
Gly Phe Thr Phe Ser Ser Tyr Asp Val Gly
1 5 10
<210> 292
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 292
Gly Ile Val Pro Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 293
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 293
His Arg Ser Tyr Ala Tyr Tyr Ala Phe Asp Tyr
1 5 10
<210> 294
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 294
Arg Ala Ser Gln Asn Val Arg Asn Tyr Leu Gly
1 5 10
<210> 295
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 295
Asp Ala Ser Ser Leu Gln Ser
1 5
<210> 296
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 296
Gln Gln Tyr Gly Asp Trp Pro Leu Thr
1 5
<210> 297
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 297
Gly Phe Thr Phe Thr Asp Ala Tyr Met Ser
1 5 10
<210> 298
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 298
Thr Ile Ser Ser Tyr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 299
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 299
Pro Arg Tyr Ile Glu Ser Pro Val Tyr Asp Tyr
1 5 10
<210> 300
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 300
Arg Ala Ser Gln Ser Ile Ala Lys Tyr Leu Ala
1 5 10
<210> 301
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 301
Glu Thr Ser Asn Leu Gln Ser
1 5
<210> 302
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 302
Gln Gln Ser Ser Ser Ser Pro Glu Thr
1 5
<210> 303
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 303
Gly Phe Thr Phe Thr Asn Tyr Trp Met His
1 5 10
<210> 304
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 304
Thr Ile Ile Tyr Asp Gly Gly Glu Thr Gly Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 305
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 305
Asn Ser Arg Lys Ser Gly Met Asp Tyr
1 5
<210> 306
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 306
Arg Ala Ser Gln Ser Ile Tyr Lys Tyr Leu Asn
1 5 10
<210> 307
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 307
Asp Ala Ser Thr Leu Gln Ser
1 5
<210> 308
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 308
Met Gln Tyr Tyr Ser Asp Pro Leu Thr
1 5
<210> 309
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 309
Gly Phe Thr Phe Ser Gly Tyr Ala Trp Ser
1 5 10
<210> 310
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 310
Met Ile Ser Pro Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 311
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 311
Asp Arg Asn Ala Gly Gly Asp Ser Tyr Tyr Ser Phe Asp Val
1 5 10
<210> 312
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 312
Arg Ala Ser Gln Ser Ile Asn Ser His Leu Ala
1 5 10
<210> 313
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 313
Ala Ala Ile Asn Leu Gln Ser
1 5
<210> 314
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 314
Gln Gln Thr Asn His Tyr Pro Leu Thr
1 5
<210> 315
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 315
Gly Phe Thr Phe Ser Ser His Ala Met His
1 5 10
<210> 316
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 316
Ser Ile Leu Ser Gly Gly Ser Glu Thr Asn Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 317
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 317
Asp Thr Tyr Glu Val Thr Gly Asn Leu Leu Asp Tyr
1 5 10
<210> 318
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 318
Arg Ala Ser Gln Ser Val Trp Ser Tyr Leu Asn
1 5 10
<210> 319
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 319
Gly Ala Ser Ser Leu Gln Ser
1 5
<210> 320
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 320
Met Gln Ser Tyr Ser Trp Pro Phe Thr
1 5
<210> 321
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 321
Gly Phe Thr Phe Asn Glu Tyr Ala Met Ser
1 5 10
<210> 322
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 322
Ser Ile Ile Pro Asp Gly Ser Glu Thr Asp Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 323
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 323
Ser Leu Ser Ser Ser Gly Met His Gly Asp Ile
1 5 10
<210> 324
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 324
Arg Ala Ser Gln Ser Ile Asn Asn Tyr Leu Asn
1 5 10
<210> 325
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 325
Lys Ala Ser Thr Leu Gln Ser
1 5
<210> 326
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 326
His Gln Tyr His Ser Pro Tyr Thr
1 5
<210> 327
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 327
Gly Phe Thr Phe Ser Asp Tyr Gly Trp His
1 5 10
<210> 328
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 328
Ile Ile Glu Ser Asp Gly Ser Gly Thr Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 329
<211> 18
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 329
Asn Gly Glu Val Gly Glu Arg Gly Val Arg Asp Tyr Asp Tyr Ala Met
1 5 10 15
Asp Tyr
<210> 330
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 330
Arg Ala Ser Gln Ser Ile Asn Arg Tyr Leu Asn
1 5 10
<210> 331
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 331
Ala Thr Ser Ser Leu Gln Ser
1 5
<210> 332
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 332
Gln Gln Tyr Gly Ser Thr Pro Ile Thr
1 5
<210> 333
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 333
Gly Phe Thr Phe Thr Asp Tyr Asn Val His
1 5 10
<210> 334
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 334
Gly Ile Asn Ser Ser Gly Ser Glu Thr Asn Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 335
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 335
Asp Ser Val Phe Lys Thr Val Gly Gly Tyr Asp Ala Val Met Asp Tyr
1 5 10 15
<210> 336
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 336
Arg Ala Ser Gln Ser Ile Tyr Asn Tyr Leu Ala
1 5 10
<210> 337
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 337
Gly Thr Ser Thr Leu Gln Ser
1 5
<210> 338
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 338
Met Gln Ser Tyr Ser Ser Pro Thr Thr
1 5
<210> 339
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 339
Gly Phe Thr Phe Lys Asp Tyr Trp Leu Ser
1 5 10
<210> 340
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 340
Ile Ile Asn Tyr Gly Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 341
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 341
Thr Gln Thr Ser Tyr Val Met Asp Tyr
1 5
<210> 342
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 342
Arg Ala Ser Gln Ser Val Arg Ser Gly Leu Asn
1 5 10
<210> 343
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 343
Ala Ala Ser Ser Leu Gln Ser
1 5
<210> 344
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 344
Met Gln Ser His Ser Trp Pro Leu Thr
1 5
<210> 345
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 345
Gly Phe Thr Phe Ser Ser Gly Tyr Met Ser
1 5 10
<210> 346
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 346
Thr Ile Ser Gly Ser Gly Arg Glu Thr Asn Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 347
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 347
Asp Ala Trp Gly Gly Asp Ser Tyr Phe Asp Pro
1 5 10
<210> 348
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 348
Arg Ala Ser Gln Ser Ile Trp Ser Asn Leu Ser
1 5 10
<210> 349
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 349
Asn Ala Ser Ser Leu Gln Ser
1 5
<210> 350
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 350
Gln Gln Tyr His Gly Thr Pro Ile Thr
1 5
<210> 351
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 351
Gly Phe Thr Phe Thr Asp Tyr Gln Met Ser
1 5 10
<210> 352
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 352
Thr Ile Ile Trp Ser Gly Ser Glu Thr Asn Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 353
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 353
Asn Lys Thr Pro Phe Asp Tyr
1 5
<210> 354
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 354
Arg Ala Ser Gln Ser Ile Arg Thr His Leu Ala
1 5 10
<210> 355
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 355
Asp Asn Ser Asn Leu Gln Ser
1 5
<210> 356
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 356
Gln Gln Tyr Lys Gly Ser Pro Leu Thr
1 5
<210> 357
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 357
Gly Phe Thr Phe Thr Ser Tyr Ala Met Ser
1 5 10
<210> 358
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 358
Ser Ile Ser Tyr Ser Gly Gly Glu Thr Asp Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 359
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 359
Ser Lys Gly Gly Leu Tyr Phe Asp Tyr
1 5
<210> 360
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 360
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala
1 5 10
<210> 361
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 361
Gly Ala Ser Ser Leu Gln Ser
1 5
<210> 362
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 362
Gln Gln Tyr Gly Ser Thr Pro Glu Thr
1 5
<210> 363
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 363
Gly Phe Thr Phe Ser Gly Tyr Trp Ile His
1 5 10
<210> 364
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 364
Thr Ile Ser Tyr Ser Gly Asp Glu Ala Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 365
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 365
Ser Pro Ser Asp Gly Asp Tyr Gly Phe Asp Tyr
1 5 10
<210> 366
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 366
Arg Ala Ser Gln Ser Ile Asn Asn Tyr Leu Ser
1 5 10
<210> 367
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 367
Asp Gly Arg Ile Leu Gln Ser
1 5
<210> 368
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 368
Met Gln Tyr Leu Ala Tyr Pro Trp Thr
1 5
<210> 369
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 369
Gly Phe Thr Phe Gly Thr Tyr Asp Met His
1 5 10
<210> 370
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 370
Met Ile Ser Pro Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 371
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 371
Asp Ser Ser Gly Asp Trp Tyr Ala Met Ala Tyr
1 5 10
<210> 372
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 372
Arg Ala Ser Gln Ser Ile Arg Arg Tyr Leu Ala
1 5 10
<210> 373
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 373
Gly Ala Ser Asn Leu Gln Ser
1 5
<210> 374
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 374
Gln His Ser Ser Asp Thr Pro Leu Thr
1 5
<210> 375
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 375
Gly Phe Thr Phe Ser Asp Ser Ala Met Gly
1 5 10
<210> 376
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 376
Ile Ile Ser Tyr Tyr Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val Lys
1 5 10 15
Gly
<210> 377
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 377
Asn Pro Asp Gly Asp Leu Ser Ala Leu Asp Tyr
1 5 10
<210> 378
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 378
Arg Ala Ser Gln Pro Ile Ser Ser Tyr Leu Asn
1 5 10
<210> 379
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 379
Gly Ala Ser Ser Leu Gln Ser
1 5
<210> 380
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 合成的
<400> 380
Gln Gln Arg Leu Arg Ser Pro Phe Thr
1 5
Claims (10)
1.一种抗人Mac-1抗体，其中所述抗体与特定状态的人Mac-1结合，并通过TLR活化的免疫细胞调节Th1细胞因子和/或Th2细胞因子分泌。
2.根据权利要求1所述的抗体，其中所述Th1细胞因子分泌的增强程度大于所述Th2细胞因子分泌的增强程度。
3.根据权利要求1所述的抗体，其中所述抗体包含具有CDR-H1、CDR-H2和CDR-H3序列的重链可变区序列；以及具有CDR-L1、CDR-L2和CDR-L3序列的轻链可变区序列，其中
所述CDR-H1具有序列SEQ ID NO：543、549、483、369、189、159、165、171、177、183、195、201、207、213、219、225、231、237、243、249、255、261、267、273、279、285、291、297、303、309、315、321、327、333、339、345、351、357、363、375、381、387、393、399、405、411、417、423、429、435、441、447、453、459、465、471、477、489、495、501、507、513、519、525、531或537；
所述CDR-H2具有序列SEQ ID NO：544、550、484、370、190、160、166、172、178、184、196、202、208、214、220、226、232、238、244、250、256、262、268、274、280、286、292、298、304、310、316、322、328、334、340、346、352、358、364、376、382、388、394、400、406、412、418、424、430、436、442、448、454、460、466、472、478、490、496、502、508、514、520、526、532或538；
所述CDR-H3具有序列SEQ ID NO：545、551、485、371、191、161、167、173、179、185、197、203、209、215、221、227、233、239、245、251、257、263、269、275、281、287、293、299、305、311、317、323、329、335、341、347、353、359、365、377、383、389、395、401、407、413、419、425、431、437、443、449、455、461、467、473、479、491、497、503、509、515、521、527、533或539；
所述CDR-L1具有序列SEQ ID NO：546、552、486、372、192、162、168、174、180、186、198、204、210、216、222、228、234、240、246、252、258、264、270、276、282、288、294、300、306、312、318、324、330、336、342、348、354、360、366、378、384、390、396、402、408、414、420、426、432、438、444、450、456、462、468、474、480、492、498、504、510、516、522、528、534或540；
所述CDR-L2具有序列SEQ ID NO：547、553、487、373、193、163、169、175、181、187、199、205、211、217、223、229、235、241、247、253、259、265、271、277、283、289、295、301、307、313、319、325、331、337、343、349、355、361、367、379、385、391、397、403、409、415、421、427、433、439、445、451、457、463、469、475、481、493、499、505、511、517、523、529、535或541；并且
所述CDR-L3具有序列SEQ ID NO：548、554、488、374、194、164、170、176、182、188、200、206、212、218、224、230、236、242、248、254、260、266、272、278、284、290、296、302、308、314、320、326、332、338、344、350、356、362、368、380、386、392、398、404、410、416、422、428、434、440、446、452、458、464、470、476、482、494、500、506、512、518、524、530、536或542。
4.根据权利要求1所述的抗人Mac-1抗体，其中所述CDR-H1、CDR-H2、CDR-H3、CDR-L1、CDR-L2和CDR-L3具有序列SEQ ID NO：159-164、或SEQ ID NO：165-170、或SEQ ID NO：171-176、或SEQ ID NO：177-182、或SEQ ID NO：183-188、或SEQ ID NO：189-194、或SEQ ID NO：195-200、或SEQ ID NO：201-206、或SEQ ID NO：207-212、或SEQ ID NO：213-218、或SEQ IDNO：219-224、或SEQ ID NO：225-230、或SEQ ID NO：231-236、或SEQ ID NO：237-242、或SEQID NO：243-248、或SEQ ID NO：249-254、或SEQ ID NO：255-260、或SEQ ID NO：261-266、或SEQ ID NO：267-272、或SEQ ID NO：273-278、或SEQ ID NO：279-284、或SEQ ID NO：285-290、或SEQ ID NO：291-296、或SEQ ID NO：297-302、或SEQ ID NO：303-308、或SEQ ID NO：309-314、或SEQ ID NO：315-320、或SEQ ID NO：321-326、或SEQ ID NO：327-332、或SEQ IDNO：333-338、或SEQ ID NO：339-344、或SEQ ID NO：345-350、或SEQ ID NO：351-356、或SEQID NO：357-362、或SEQ ID NO：363-368、或SEQ ID NO：369-374、或SEQ ID NO：375-380、或SEQ ID NO：381-386、或SEQ ID NO：387-392、或SEQ ID NO：393-398、或SEQ ID NO：399-404、或SEQ ID NO：405-410、或SEQ ID NO：411-416、或SEQ ID NO：417-422、或SEQ ID NO：423-428、或SEQ ID NO：429-434、或SEQ ID NO：435-440、或SEQ ID NO：441-446、或SEQ IDNO：447-452、或SEQ ID NO：453-458、或SEQ ID NO：459-464、或SEQ ID NO：465-470、或SEQID NO：471-476、或SEQ ID NO：477-482、或SEQ ID NO：483-488、或SEQ ID NO：489-494、或SEQ ID NO：495-500、或SEQ ID NO：501-506、或SEQ ID NO：507-512、或SEQ ID NO：513-518、或SEQ ID NO：519-524、或SEQ ID NO：525-530、或SEQ ID NO：531-536、或SEQ ID NO：537-542、或SEQ ID NO：543-548、或SEQ ID NO：549-554。
5.根据权利要求1所述的抗人Mac-1抗体，其中所述CDR-H1、CDR-H2、CDR-H3、CDR-L1、CDR-L2和CDR-L3具有序列SEQ ID NO：543-548、或SEQ ID NO：549-554、或SEQ ID NO：483-488、或SEQ ID NO：369-374、或SEQ ID NO：189-194。
6.根据权利要求1所述的抗人Mac-1抗体，其中所述重链可变区序列为SEQ ID NO：1、3、5、7、9、11、13、15、17、19、21、23、25、27、29、31、33、35、37、39、41、43、45、47、49、51、53、55、57、59、61、63、65、67、69、71、73、75、77、79、81、83、85、87、89、91、93、95、97、99、101、103、105、107、109、111、113、115、117、119、121、123、125、127、129、131、133、135、137、139、141、143、145、147、149、151、153、155、或157；并且所述轻链可变区序列为SEQ ID NO：2、4、6、8、10、12、14、16、18、20、22、24、26、28、30、32、34、36、38、40、42、44、46、48、50、52、54、56、58、60、62、64、66、68、70、72、74、76、78、80、82、84、86、88、90、92、94、96、98、100、102、104、106、108、110、112、114、116、118、120、122、124、126、128、130、132、134、136、138、140、142、144、146、148、150、152、154、156、或158。
7.根据权利要求1所述的抗人Mac-1抗体，其中所述重链可变区序列和所述轻链可变区序列具有以下序列对：SEQ ID NO：1和2、或SEQ ID NO：3和4、或SEQ ID NO：5和6、或SEQ IDNO：7和8、或SEQ ID NO：9和10、或SEQ ID NO：11和12、或SEQ ID NO：13和14、或SEQ ID NO：15和16、或SEQ ID NO：17和18、或SEQ ID NO：19和20、或SEQ ID NO：21和22、或SEQ ID NO：23和24、或SEQ ID NO：25和26、或SEQ ID NO：27和28、或SEQ ID NO：29和30、或SEQ ID NO：31和32、或SEQ ID NO：33和34、或SEQ ID NO：35和36、或SEQ ID NO：37和38、或SEQ ID NO：39和40、或SEQ ID NO：41和42、或SEQ ID NO：43和44、或SEQ ID NO：45和46、或SEQ ID NO：47和48、或SEQ ID NO：49和50、或SEQ ID NO：51和52、或SEQ ID NO：53和54、或SEQ ID NO：55和56、或SEQ ID NO：57和58、或SEQ ID NO：59和60、或SEQ ID NO：61和62、或SEQ ID NO：63和64、或SEQ ID NO：65和66、或SEQ ID NO：67和68、或SEQ ID NO：69和70、或SEQ ID NO：71和72、或SEQ ID NO：73和74、或SEQ ID NO：75和76、或SEQ ID NO：77和78、或SEQ ID NO：79和80、或SEQ ID NO：81和82、或SEQ ID NO：83和842、或SEQ ID NO：85和86、或SEQ ID NO：87和88、或SEQ ID NO：89和90、或SEQ ID NO：91和92、或SEQ ID NO：93和94、或SEQ ID NO：95和96、或SEQ ID NO：97和98、或SEQ ID NO：99和100、或SEQ ID NO：101和102、或SEQ IDNO：103和104、或SEQ ID NO：105和106、或SEQ ID NO：107和108、或SEQ ID NO：109和110、或SEQ ID NO：111和112、或SEQ ID NO：113和114、或SEQ ID NO：115和116、或SEQ ID NO：117和118、或SEQ ID NO：119和120、或SEQ ID NO：121和122、或SEQ ID NO：123和124、或SEQ IDNO：125和126、或SEQ ID NO：127和128、或SEQ ID NO：129和130、或SEQ ID NO：131和132、或SEQ ID NO：133和134、或SEQ ID NO：135和136、或SEQ ID NO：137和138、或SEQ ID NO：139和140、或SEQ ID NO：141和142、或SEQ ID NO：143和144、或SEQ ID NO：145和146、或SEQ IDNO：147和148、或SEQ ID NO：149和150、或SEQ ID NO：151和152、或SEQ ID NO：153和154、或SEQ ID NO：155和156、或SEQ ID NO：157和158。
8.根据权利要求1所述的抗人Mac-1抗体，其中所述所述重链可变区序列和所述轻链可变区序列具有以下序列对：SEQ ID NO:129和130、或SEQ ID NO：131和132、或SEQ ID NO：133和134、或SEQ ID NO：71和72、或SEQ ID NO：11和12。
9.一种用于治疗与急性和慢性炎症或癌症相关的疾病或障碍的药物组合物，其中所述药物组合物包含根据权利要求1至8中任一项所述的抗体以及药学上可接受的载体或赋形剂。
10.一种用于治疗与急性和慢性炎症或癌症相关的疾病或障碍的方法，包括：向有此需要的对象给药有效量的根据权利要求1至8中任一项所述的抗体。
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