CN116940582A - 寡核苷酸、试剂及其制备 - Google Patents

寡核苷酸、试剂及其制备 Download PDF

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Publication number
CN116940582A
CN116940582A CN202180089208.3A CN202180089208A CN116940582A CN 116940582 A CN116940582 A CN 116940582A CN 202180089208 A CN202180089208 A CN 202180089208A CN 116940582 A CN116940582 A CN 116940582A
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group
formula
salt
independently
compound
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CN202180089208.3A
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English (en)
Chinese (zh)
Inventor
严无名
周旋
石向林
F·安蒂亚
W·F·基斯曼
Y·菲永
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Bojian Massachusetts Co ltd
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Bojian Massachusetts Co ltd
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Publication of CN116940582A publication Critical patent/CN116940582A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202180089208.3A 2020-11-11 2021-11-10 寡核苷酸、试剂及其制备 Pending CN116940582A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063112281P 2020-11-11 2020-11-11
US63/112,281 2020-11-11
PCT/US2021/058786 WO2022103842A1 (en) 2020-11-11 2021-11-10 Oligonucleotides, reagents and preparation thereof

Publications (1)

Publication Number Publication Date
CN116940582A true CN116940582A (zh) 2023-10-24

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CN202180089208.3A Pending CN116940582A (zh) 2020-11-11 2021-11-10 寡核苷酸、试剂及其制备

Country Status (10)

Country Link
US (1) US20230406878A1 (https=)
EP (1) EP4244232A1 (https=)
JP (1) JP2023551647A (https=)
KR (1) KR20230106665A (https=)
CN (1) CN116940582A (https=)
AU (1) AU2021377229A1 (https=)
CA (1) CA3198433A1 (https=)
IL (1) IL302825A (https=)
MX (1) MX2023005467A (https=)
WO (1) WO2022103842A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119306779A (zh) * 2024-12-13 2025-01-14 上海科泽永欣生物科技有限公司 一种含r构型的起始加帽寡核苷酸引物及其合成方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024089953A1 (ja) * 2022-10-27 2024-05-02 住友化学株式会社 オリゴヌクレオチドの製造方法
WO2025235761A1 (en) 2024-05-09 2025-11-13 Biogen Ma Inc. Reagents and processes for preparing oligonucleotides

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5969148A (en) * 1998-12-02 1999-10-19 Eastman Kodak Company One-pot synthesis of pyrazolotriazole photographic dye forming color couplers and coupler intermediates
CN101875617A (zh) * 2009-03-23 2010-11-03 中国医学科学院药物研究所 烷氧基取代芳环的氨甲酰基类芳酸化合物及其制法和用途
JP2012111728A (ja) * 2010-11-26 2012-06-14 Nokodai Tlo Kk 高分散性液相支持体を用いたオリゴヌクレオチド合成法
CN107513020A (zh) * 2017-08-01 2017-12-26 南昌大学 一种间碘硝基苯化合物的合成方法
CN108350018A (zh) * 2015-11-17 2018-07-31 日产化学工业株式会社 寡核苷酸的制造方法
CN110128299A (zh) * 2019-05-13 2019-08-16 浙江大学 一种二苯基脲类抗肿瘤小分子抑制剂及其制备方法
CN110234643A (zh) * 2017-01-27 2019-09-13 基恩菲特公司 RORγ调节剂及其用途
WO2019180683A1 (en) * 2018-03-23 2019-09-26 Takeda Pharmaceutical Company Limited Sting modulator compounds with sulfamate linkages, and methods of making and using

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2694635A (en) * 1951-12-05 1954-11-16 Eastman Kodak Co Couplers for color photography
DE2032171A1 (de) * 1970-06-30 1972-01-13 Agfa Gevaert AG, 5090 Leverkusen Lichtempfindliches farbfotografisches Material
DE19908763A1 (de) * 1999-02-18 2000-08-24 Schering Ag Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
EP1479666A4 (en) * 2002-02-28 2010-10-13 Japan Tobacco Inc ESTER CONNECTION AND THEIR MEDICAL USE
EP2816053B1 (en) * 2012-02-17 2021-03-24 Ajinomoto Co., Inc. Base-protected oligonucleotide
CN116063365A (zh) * 2015-12-16 2023-05-05 味之素株式会社 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸
KR20190090301A (ko) * 2018-01-24 2019-08-01 에스티팜 주식회사 신규한 뉴클레오사이드 또는 뉴클레오타이드 유도체 및 이들의 용도
JP6770553B2 (ja) * 2018-07-20 2020-10-14 藤本化学製品株式会社 アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
CN119143828A (zh) 2019-05-08 2024-12-17 渤健马萨诸塞州股份有限公司 寡核苷酸的汇聚液相合成

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5969148A (en) * 1998-12-02 1999-10-19 Eastman Kodak Company One-pot synthesis of pyrazolotriazole photographic dye forming color couplers and coupler intermediates
CN101875617A (zh) * 2009-03-23 2010-11-03 中国医学科学院药物研究所 烷氧基取代芳环的氨甲酰基类芳酸化合物及其制法和用途
JP2012111728A (ja) * 2010-11-26 2012-06-14 Nokodai Tlo Kk 高分散性液相支持体を用いたオリゴヌクレオチド合成法
CN108350018A (zh) * 2015-11-17 2018-07-31 日产化学工业株式会社 寡核苷酸的制造方法
CN110234643A (zh) * 2017-01-27 2019-09-13 基恩菲特公司 RORγ调节剂及其用途
CN107513020A (zh) * 2017-08-01 2017-12-26 南昌大学 一种间碘硝基苯化合物的合成方法
WO2019180683A1 (en) * 2018-03-23 2019-09-26 Takeda Pharmaceutical Company Limited Sting modulator compounds with sulfamate linkages, and methods of making and using
CN110128299A (zh) * 2019-05-13 2019-08-16 浙江大学 一种二苯基脲类抗肿瘤小分子抑制剂及其制备方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
LEYI GONG ET AL.: "Design and synthesis of novel CCR3 antagonists", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》, vol. 13, no. 20, 31 December 2003 (2003-12-31), pages 3597 - 3600 *
THIERRY LEÓN ET AL.: "Ni-Catalyzed Direct Carboxylation of Benzyl Halides with CO2Click to copy article link", 《JOURNAL OF THE AMERICAN CHEMICAL SOCIETY》, vol. 135, no. 4, 9 January 2013 (2013-01-09), pages 1221 - 1224 *
TYPHAINE GUERLAVAIS-DAGLAND ET AL.: "Fluoride-Labile Protecting Groups for the Synthesis of Base-Sensitive Methyl-SATE Oligonucleotide Prodrugs", 《EUR. J. ORG. CHEM.》, 31 December 2003 (2003-12-31), pages 2327 - 2335 *
YUKI MATSUNO ET AL.: "Synthetic Method for Oligonucleotide Block by Using Alkyl-Chain Soluble Support", 《ORG.LETT.》, vol. 18, 4 February 2016 (2016-02-04), pages 800 - 803 *
YUKI MATSUNO ET AL.: "Synthetic Method for Oligonucleotide Block by Using Alkyl-Chain-Soluble Support", 《ORGANIC LETTERS》, vol. 18, no. 4, 4 February 2016 (2016-02-04), pages 800 - 803 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119306779A (zh) * 2024-12-13 2025-01-14 上海科泽永欣生物科技有限公司 一种含r构型的起始加帽寡核苷酸引物及其合成方法

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WO2022103842A1 (en) 2022-05-19
MX2023005467A (es) 2023-07-27
EP4244232A1 (en) 2023-09-20
IL302825A (en) 2023-07-01
US20230406878A1 (en) 2023-12-21
CA3198433A1 (en) 2022-05-19
JP2023551647A (ja) 2023-12-12
AU2021377229A1 (en) 2023-06-29
KR20230106665A (ko) 2023-07-13

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