MX2023005467A - Oligonucleotidos, reactivos y su preparacion. - Google Patents

Oligonucleotidos, reactivos y su preparacion.

Info

Publication number
MX2023005467A
MX2023005467A MX2023005467A MX2023005467A MX2023005467A MX 2023005467 A MX2023005467 A MX 2023005467A MX 2023005467 A MX2023005467 A MX 2023005467A MX 2023005467 A MX2023005467 A MX 2023005467A MX 2023005467 A MX2023005467 A MX 2023005467A
Authority
MX
Mexico
Prior art keywords
oligonucleotides
reagents
preparation
nucleotides
reagent
Prior art date
Application number
MX2023005467A
Other languages
English (en)
Inventor
Xianglin Shi
William F Kiesman
Wuming Yan
Firoz Antia
Yannick Fillon
Xuan Zhou
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of MX2023005467A publication Critical patent/MX2023005467A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente descripción describe reactivos y procesos novedosos para preparar oligonucleótidos, que tienen dos o más nucleótidos; en una modalidad, el reactivo está representado por la Fórmula I' o B. (ver formula).
MX2023005467A 2020-11-11 2021-11-10 Oligonucleotidos, reactivos y su preparacion. MX2023005467A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063112281P 2020-11-11 2020-11-11
PCT/US2021/058786 WO2022103842A1 (en) 2020-11-11 2021-11-10 Oligonucleotides, reagents and preparation thereof

Publications (1)

Publication Number Publication Date
MX2023005467A true MX2023005467A (es) 2023-07-27

Family

ID=79425665

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023005467A MX2023005467A (es) 2020-11-11 2021-11-10 Oligonucleotidos, reactivos y su preparacion.

Country Status (10)

Country Link
US (1) US20230406878A1 (es)
EP (1) EP4244232A1 (es)
JP (1) JP2023551647A (es)
KR (1) KR20230106665A (es)
CN (1) CN116940582A (es)
AU (1) AU2021377229A1 (es)
CA (1) CA3198433A1 (es)
IL (1) IL302825A (es)
MX (1) MX2023005467A (es)
WO (1) WO2022103842A1 (es)

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2694635A (en) * 1951-12-05 1954-11-16 Eastman Kodak Co Couplers for color photography
DE2032171A1 (de) * 1970-06-30 1972-01-13 Agfa Gevaert AG, 5090 Leverkusen Lichtempfindliches farbfotografisches Material
US5969148A (en) * 1998-12-02 1999-10-19 Eastman Kodak Company One-pot synthesis of pyrazolotriazole photographic dye forming color couplers and coupler intermediates
DE19908763A1 (de) * 1999-02-18 2000-08-24 Schering Ag Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
AU2003211617C1 (en) * 2002-02-28 2008-03-06 Japan Tobacco Inc. Ester compound and medicinal use thereof
CN101875617B (zh) * 2009-03-23 2015-05-20 中国医学科学院药物研究所 烷氧基取代芳环的氨甲酰基类芳酸化合物及其制法和用途
JP5705512B2 (ja) * 2010-11-26 2015-04-22 農工大ティー・エル・オー株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
IN2014DN06768A (es) * 2012-02-17 2015-05-22 Ajinomoto Kk
EP3378869A4 (en) * 2015-11-17 2019-09-18 Nissan Chemical Corporation PROCESS FOR THE PREPARATION OF OLIGONUCLEOTIDES
CN116063365A (zh) * 2015-12-16 2023-05-05 味之素株式会社 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸
WO2018138359A1 (en) * 2017-01-27 2018-08-02 Genfit Rorgamma modulators and uses thereof
CN107513020B (zh) * 2017-08-01 2019-10-29 南昌大学 一种间碘硝基苯化合物的合成方法
KR20190090301A (ko) * 2018-01-24 2019-08-01 에스티팜 주식회사 신규한 뉴클레오사이드 또는 뉴클레오타이드 유도체 및 이들의 용도
WO2019180683A1 (en) * 2018-03-23 2019-09-26 Takeda Pharmaceutical Company Limited Sting modulator compounds with sulfamate linkages, and methods of making and using
JP6770553B2 (ja) * 2018-07-20 2020-10-14 藤本化学製品株式会社 アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
CA3139545A1 (en) 2019-05-08 2020-11-12 Biogen Ma Inc. Convergent liquid phase syntheses of oligonucleotides
CN110128299B (zh) * 2019-05-13 2020-11-10 浙江大学 一种二苯基脲类抗肿瘤小分子抑制剂及其制备方法

Also Published As

Publication number Publication date
JP2023551647A (ja) 2023-12-12
WO2022103842A1 (en) 2022-05-19
CN116940582A (zh) 2023-10-24
KR20230106665A (ko) 2023-07-13
AU2021377229A1 (en) 2023-06-29
IL302825A (en) 2023-07-01
EP4244232A1 (en) 2023-09-20
CA3198433A1 (en) 2022-05-19
US20230406878A1 (en) 2023-12-21

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