MX2023005467A - Oligonucleotidos, reactivos y su preparacion. - Google Patents
Oligonucleotidos, reactivos y su preparacion.Info
- Publication number
- MX2023005467A MX2023005467A MX2023005467A MX2023005467A MX2023005467A MX 2023005467 A MX2023005467 A MX 2023005467A MX 2023005467 A MX2023005467 A MX 2023005467A MX 2023005467 A MX2023005467 A MX 2023005467A MX 2023005467 A MX2023005467 A MX 2023005467A
- Authority
- MX
- Mexico
- Prior art keywords
- oligonucleotides
- reagents
- preparation
- nucleotides
- reagent
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063112281P | 2020-11-11 | 2020-11-11 | |
| PCT/US2021/058786 WO2022103842A1 (en) | 2020-11-11 | 2021-11-10 | Oligonucleotides, reagents and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023005467A true MX2023005467A (es) | 2023-07-27 |
Family
ID=79425665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023005467A MX2023005467A (es) | 2020-11-11 | 2021-11-10 | Oligonucleotidos, reactivos y su preparacion. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230406878A1 (https=) |
| EP (1) | EP4244232A1 (https=) |
| JP (1) | JP2023551647A (https=) |
| KR (1) | KR20230106665A (https=) |
| CN (1) | CN116940582A (https=) |
| AU (1) | AU2021377229A1 (https=) |
| CA (1) | CA3198433A1 (https=) |
| IL (1) | IL302825A (https=) |
| MX (1) | MX2023005467A (https=) |
| WO (1) | WO2022103842A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024089953A1 (ja) * | 2022-10-27 | 2024-05-02 | 住友化学株式会社 | オリゴヌクレオチドの製造方法 |
| WO2025235761A1 (en) | 2024-05-09 | 2025-11-13 | Biogen Ma Inc. | Reagents and processes for preparing oligonucleotides |
| CN119306779A (zh) * | 2024-12-13 | 2025-01-14 | 上海科泽永欣生物科技有限公司 | 一种含r构型的起始加帽寡核苷酸引物及其合成方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2694635A (en) * | 1951-12-05 | 1954-11-16 | Eastman Kodak Co | Couplers for color photography |
| DE2032171A1 (de) * | 1970-06-30 | 1972-01-13 | Agfa Gevaert AG, 5090 Leverkusen | Lichtempfindliches farbfotografisches Material |
| US5969148A (en) * | 1998-12-02 | 1999-10-19 | Eastman Kodak Company | One-pot synthesis of pyrazolotriazole photographic dye forming color couplers and coupler intermediates |
| DE19908763A1 (de) * | 1999-02-18 | 2000-08-24 | Schering Ag | Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
| EP1479666A4 (en) * | 2002-02-28 | 2010-10-13 | Japan Tobacco Inc | ESTER CONNECTION AND THEIR MEDICAL USE |
| CN101875617B (zh) * | 2009-03-23 | 2015-05-20 | 中国医学科学院药物研究所 | 烷氧基取代芳环的氨甲酰基类芳酸化合物及其制法和用途 |
| JP5705512B2 (ja) * | 2010-11-26 | 2015-04-22 | 農工大ティー・エル・オー株式会社 | 高分散性液相支持体を用いたオリゴヌクレオチド合成法 |
| EP2816053B1 (en) * | 2012-02-17 | 2021-03-24 | Ajinomoto Co., Inc. | Base-protected oligonucleotide |
| TWI729028B (zh) * | 2015-11-17 | 2021-06-01 | 日商日產化學工業股份有限公司 | 寡核苷酸的製造方法 |
| CN116063365A (zh) * | 2015-12-16 | 2023-05-05 | 味之素株式会社 | 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸 |
| CA3050056A1 (en) * | 2017-01-27 | 2018-08-02 | Genfit | Rorgamma modulators and uses thereof |
| CN107513020B (zh) * | 2017-08-01 | 2019-10-29 | 南昌大学 | 一种间碘硝基苯化合物的合成方法 |
| KR20190090301A (ko) * | 2018-01-24 | 2019-08-01 | 에스티팜 주식회사 | 신규한 뉴클레오사이드 또는 뉴클레오타이드 유도체 및 이들의 용도 |
| WO2019180683A1 (en) * | 2018-03-23 | 2019-09-26 | Takeda Pharmaceutical Company Limited | Sting modulator compounds with sulfamate linkages, and methods of making and using |
| JP6770553B2 (ja) * | 2018-07-20 | 2020-10-14 | 藤本化学製品株式会社 | アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法 |
| CN119143828A (zh) | 2019-05-08 | 2024-12-17 | 渤健马萨诸塞州股份有限公司 | 寡核苷酸的汇聚液相合成 |
| CN110128299B (zh) * | 2019-05-13 | 2020-11-10 | 浙江大学 | 一种二苯基脲类抗肿瘤小分子抑制剂及其制备方法 |
-
2021
- 2021-11-10 KR KR1020237019471A patent/KR20230106665A/ko active Pending
- 2021-11-10 US US18/036,459 patent/US20230406878A1/en active Pending
- 2021-11-10 JP JP2023528215A patent/JP2023551647A/ja active Pending
- 2021-11-10 EP EP21841044.7A patent/EP4244232A1/en active Pending
- 2021-11-10 AU AU2021377229A patent/AU2021377229A1/en active Pending
- 2021-11-10 CA CA3198433A patent/CA3198433A1/en active Pending
- 2021-11-10 MX MX2023005467A patent/MX2023005467A/es unknown
- 2021-11-10 WO PCT/US2021/058786 patent/WO2022103842A1/en not_active Ceased
- 2021-11-10 CN CN202180089208.3A patent/CN116940582A/zh active Pending
- 2021-11-10 IL IL302825A patent/IL302825A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022103842A1 (en) | 2022-05-19 |
| CN116940582A (zh) | 2023-10-24 |
| EP4244232A1 (en) | 2023-09-20 |
| IL302825A (en) | 2023-07-01 |
| US20230406878A1 (en) | 2023-12-21 |
| CA3198433A1 (en) | 2022-05-19 |
| JP2023551647A (ja) | 2023-12-12 |
| AU2021377229A1 (en) | 2023-06-29 |
| KR20230106665A (ko) | 2023-07-13 |
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