CN116920065A - 一种用于治疗烧烫伤的药膏及其制备方法 - Google Patents
一种用于治疗烧烫伤的药膏及其制备方法 Download PDFInfo
- Publication number
- CN116920065A CN116920065A CN202311126048.2A CN202311126048A CN116920065A CN 116920065 A CN116920065 A CN 116920065A CN 202311126048 A CN202311126048 A CN 202311126048A CN 116920065 A CN116920065 A CN 116920065A
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- Prior art keywords
- parts
- ointment
- scalds
- treating burns
- beeswax
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Abstract
本发明公开一种用于治疗烧烫伤的药膏及其制备方法，按质量份包括以下组分：90‑100份花生油、180‑200份蜂蜡、20‑30份石膏、20‑30份黄柏、20‑30份丹参、10‑15份黄芩、25‑30份苦参、20‑30份紫草、20‑30份益母草、20‑30份芦荟、20‑30份黄连、10‑15份白花蛇舌草、10‑15份珍珠母、30‑40份甲壳质、20‑30份姜黄、10‑15份椒棘豆；通过本发明方案制备出的贴膏具去腐生肌、消炎止痛、清热燥湿、抗菌消炎、保护血管、活血化瘀的功效，同时其制备简单、使用方便、用药后无副作用，安全可靠、疗程短、疗效快、效果好，适用于治疗烧烫伤，且服帖性好，可以缓解由于药膏敷贴后引起的瘙痒、刺痛，与由于敷药时长较久引起的皮肤变色。
Description
技术领域
本发明涉及中药药膏制备技术领域，具体为一种用于治疗烧烫伤的药膏及其制备方法。
背景技术
烧伤是一种很普遍的皮肤损害，一般是因为与高温或化学物质的接触所造成的。烧烫伤有可能是热烫伤，火烫伤，蒸汽烫伤，也有可能是化学烫伤。烧烫伤常根据伤口深度和范围进行分类，通常分为一度烧伤(表浅损伤)、二度烧伤(浅表性烧伤和深层浸润性烧伤)和三度烧伤(全层损伤)。症状：烧烫伤的症状包括疼痛、水泡、红肿、皮肤脱屑、糜烂、瘢痕等。严重的烧伤可能伴有神经功能障碍、呼吸困难、休克和全身炎症反应等。
而常见烧伤烫伤是由于开水、沸油、火、电或酸碱物质等作用于人体皮肤而引起的一种复杂的外科疾病，一般以火烧伤和开水(油)烫伤为常见。轻度的烧伤或烫伤表皮发生红肿、灼痛或起水泡；严重的烧伤烫伤，由于损伤人的皮肤及皮下组织，火毒伤及体内阴液，内攻脏腑，伤阴损阳，常常导致人体内水和电解质平衡失调，皮肤组织红肿、溃烂、感染等严重后果。若不及时治疗创面，因感染会久不愈合，导致疤痕的产生，影响肢体功能。
目前对于烧伤、烫伤的治疗，通常都是将从中草药或矿物质中提炼出来的抗生素药物制成膏剂，然后涂抹在伤口上，也有一些病人会在伤口上涂抹一些食醋或食盐，这些药物和方法在治疗上虽然可以取得一定的效果，但是它们的消肿、止痛、生肌的效果很慢，而且治愈后往往还会留下疤痕。针对大面积烧伤、烫伤患者，因其促肌作用较慢，需通过局部换皮等方式进行修复，不但成本高昂、康复周期较长，且患者疼痛难忍。
因此，寻求一种成本低、安全、见效快、服帖性好，见效快的专门治疗烧烫伤的药膏及其制备方法具有重要的研究价值。
发明内容
针对现有技术的不足之处，本发明的目的在于提供一种用于治疗烧烫伤的药膏及其制备方法，通过本发明方案制备出的治疗烧烫伤的药膏具有去腐生肌、消炎止痛、清热燥湿、抗菌消炎、保护血管、活血化瘀的功效，同时其制备简单、使用方便、用药后无副作用，安全可靠、疗程短、疗效快、效果好，适用于烧伤烫伤等病症。
为实现上述目的，本发明提供如下技术方案：
一种用于治疗烧烫伤的药膏，按质量份包括以下组分：90-100份花生油、180-200份蜂蜡、20-30份石膏、20-30份黄柏、20-30份丹参、10-15份黄芩、25-30份苦参、20-30份紫草、20-30份益母草、20-30份芦荟、20-30份黄连、10-15份白花蛇舌草、10-15份珍珠母、30-40份甲壳质、20-30份姜黄、10-15份椒棘豆。
优选的，按质量份包括以下组分：100份花生油、180份蜂蜡、20份石膏、20份黄柏、20份丹参、10份黄芩、25份苦参、20份紫草、20份益母草、20份芦荟、20份黄连、10份白花蛇舌草、10份珍珠母、30份甲壳质、20份姜黄、10份椒棘豆。
优选的，按质量份包括以下组分：100份花生油、180份蜂蜡、24份石膏、23份黄柏、24份丹参、13份黄芩、25份苦参、23份紫草、24份益母草、24份芦荟、22份黄连、13份白花蛇舌草、12份珍珠母、34份甲壳质、23份姜黄、12份椒棘豆。
一种药膏的制备方法，用于制备所述的一种用于治疗烧烫伤的药膏，包括以下步骤：
S1.预处理：将紫草洗净备用，将其他药物饮片用水洗净过滤后放在煎药锅，加入水和饮片相平，开始用文火烧制水温至70-90℃；
S2.煎制：当S1预处理药物饮片变软至水分全部浸入饮片后将花生油加入S1中的煎药锅，武火烧制油温200-260℃煎制直至油由浑浊变成本色，饮片含水量达到45-55％；
S3.浓缩：将紫草放入S2煎制药物饮片完成的煎药锅中，再改文火烧制油温150-200℃观察，当紫草变焦、饮片变黄，即可离火过滤到容器中；
S4.药膏制备：将蜂蜡与甲壳质熔化过滤倒入步骤S3所述容器中开始搅拌并在搅拌过程中加入芦荟与珍珠母粉，直至成膏。
优选的，步骤S1与S3中，所述文火温度为：70-90℃。
优选的，步骤S2中，所述武火温度为：150-200℃。
优选的，步骤S4中，所述过滤步骤所用的滤网目数为50-80目。与现有技术相比，本发明的有益效果是：
1.本发明方案制备出的治疗烧烫伤的药膏依据中药理论与科学配伍，具去腐生肌、消炎止痛、清热燥湿、抗菌消炎、保护血管、活血化瘀的功效，经过临床验证，是一种无公害的治疗烧烫伤的药膏。
2.本发明方案制备出的治疗烧烫伤的药膏其制备过程简单、使用方便；适合于烧伤烫伤，使用后没有任何不良反应，安全可靠，疗程短，见效快，效果好，且服帖性好，可以缓解由于药膏敷贴后引起的瘙痒、刺痛，与由于敷药时长较久引起的皮肤变色。
附图说明
图1为本发明的用于治疗烧烫伤的药膏的制备工艺流程图。
具体实施方式
下面将结合本发明实施例，对本发明进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
请参阅图1，本发明提供一种技术方案：
一种用于治疗烧烫伤的药膏配方中各组分的中药药理：
石膏：味甘辛，性大寒，生肌敛疮；
花生油：抗菌消炎，保护血管；
黄柏：清热燥温，泻火除蒸，解毒疗疮；
丹参：活血化瘀，通络止痛；
黄芩：清热除湿，泻火解毒；
苦参：清热燥湿，杀虫止痒；
紫草：凉血，活血，解毒透疹；
蜂蜡：止血，安胎，补气解毒；
益母草：活血调经、利尿消肿；
芦荟：解毒抑菌，去腐生肌；
黄连：清热燥湿、泻火解毒；
白花蛇舌草：活血止痛，利尿消肿，清热解毒；
珍珠母：清热止血，补钙壮骨；
姜黄：通经止痛，破血行气，抑菌消炎；
椒棘豆：生肌愈疮，清热解毒，涩脉止血；
甲壳质：活化细胞，增稠促愈。
实施例1
一种用于治疗烧烫伤的药膏及其制备过程、原料配方与用量如下：
| 组分种类 | 用量(g) |
| 石膏 | 20 |
| 花生油 | 100 |
| 黄柏 | 20 |
| 丹参 | 20 |
| 黄芩 | 10 |
| 苦参 | 25 |
| 紫草 | 20 |
| 蜂蜡 | 180 |
| 益母草 | 20 |
| 芦荟 | 20 |
| 黄连 | 20 |
| 白花蛇舌草 | 10 |
| 珍珠母 | 10 |
| 姜黄 | 20 |
| 椒棘豆 | 10 |
| 甲壳质 | 30 |
S101.预处理：将紫草洗净备用，将其他药物饮片用水洗净过滤后放在煎药锅，加入水和饮片相平，开始用文火烧制水温至70℃；
S102.煎制：当S1预处理药物饮片变软至水分全部浸入饮片后将花生油加入S1中的煎药锅，武火烧制油温200℃煎制直至油由浑浊变成本色，饮片含水量达到45％；
S103.浓缩：将紫草放入S2煎制药物饮片完成的煎药锅中，再改文火烧制油温150℃观察，当紫草变焦、饮片变黄，即可离火过滤到容器中；
S104.药膏制备：将蜂蜡与甲壳质熔化过滤倒入步骤S3所述容器中开始搅拌并在搅拌过程中加入芦荟与珍珠母粉，直至成膏。
实施例2
一种用于治疗烧烫伤的药膏及其制备方法原料配方与用量如下：
S201.预处理：将紫草洗净备用，将其他药物饮片用水洗净过滤后放在煎药锅，加入水和饮片相平，开始用文火烧制水温至90℃；
S202.煎制：当S1预处理药物饮片变软至水分全部浸入饮片后将花生油加入S1中的煎药锅，武火烧制油温260℃煎制直至油由浑浊变成本色，饮片含水量达到55％；
S203.浓缩：将紫草放入S2煎制药物饮片完成的煎药锅中，再改文火烧制油温200℃观察，当紫草变焦、饮片变黄，即可离火过滤到容器中；
S204.药膏制备：将蜂蜡与甲壳质熔化过滤倒入步骤S3所述容器中开始搅拌并在搅拌过程中加入芦荟与珍珠母粉，直至成膏。
实施例3
一种用于治疗烧烫伤的药膏及其制备方法原料配方与用量如下：
| 组分种类 | 用量(g) |
| 石膏 | 24 |
| 花生油 | 100 |
| 黄柏 | 23 |
| 丹参 | 24 |
| 黄芩 | 13 |
| 苦参 | 25 |
| 紫草 | 23 |
| 蜂蜡 | 180 |
| 益母草 | 24 |
| 芦荟 | 24 |
| 黄连 | 22 |
| 白花蛇舌草 | 13 |
| 珍珠母 | 10 |
| 姜黄 | 23 |
| 椒棘豆 | 12 |
| 甲壳质 | 34 |
S301.预处理：将紫草洗净备用，将其他药物饮片用水洗净过滤后放在煎药锅，加入水和饮片相平，开始用文火烧制水温至80℃；
S302.煎制：当S1预处理药物饮片变软至水分全部浸入饮片后将花生油加入S1中的煎药锅，武火烧制油温230℃煎制直至油由浑浊变成本色，饮片含水量达到50％；
S303.浓缩：将紫草放入S2煎制药物饮片完成的煎药锅中，再改文火烧制油温180℃观察，当紫草变焦、饮片变黄，即可离火过滤到容器中；
S304.药膏制备：将蜂蜡与甲壳质熔化过滤倒入步骤S3所述容器中开始搅拌并在搅拌过程中加入芦荟与珍珠母粉，直至成膏。
临床试验
治疗方法：1)烧伤的初期：用0.1％的苯扎溴铵冲洗伤口，用针筒抽取脓液；2)有破溃处的感染性伤口：用双氧水多次冲洗伤口，然后用生理盐水冲洗，剪去腐烂的皮肤，去掉坏死的组织，然后用0.2％的苯扎溴铵进行灭菌。清创结束后，将麻油纱布铺在伤口上，涂上本实施例1制备的药膏，然后将伤口包好，每3天更换一次药膏，直到伤口痊愈为止。如果伤口没有出现红肿疼痛的情况，可以在伤口包扎的地方滴一些生理盐水，以利于药物的作用。对于大面积烧烫伤，如果伤口感染较严重的话，除了用本发明的外用药物进行治疗之外，还需要补充大量的液体，进行抗感染、纠正脱水和补充电解质、补充蛋白及抗休克的常规治疗。
近期统计病例84人，其中30岁以下患者47人，30-60岁患者26人，60岁以上患者11人，大部分患者贴上膏药15-30分钟后，烧烫伤引起的疼痛即获得缓解；统计结果显示，30天内治愈78人，剩余6人均有不同程度的好转，结果表明有效率100％，一疗程有效率为87％。
烫伤典型案例：
黄某某，男，34岁，安徽蚌埠市人，在外聚餐被热油烫伤手臂与小腿，经清创消毒后将实施例1提供的贴膏敷贴在烫伤创口上，半小时后疼痛明显减轻，治疗一个月后痊愈，5个月随访，患者身体状态健康，创面愈合无瘢痕生长。
李某，女，24岁，安徽省蚌埠市人，家中烧水时被开水烫伤小腿上部，经清创消毒后将实施例1提供的贴膏敷贴烫伤创口上，半小时后疼痛明显减轻，治疗一个月后痊愈，5个月随访，患者身体状态健康，创面愈合无瘢痕生长。
刘某某，男，24岁，安徽省合肥市人，电焊时被铁屑烫伤手臂，经清创消毒后将实施例1提供的贴膏敷贴烫伤创口上，半小时后疼痛明显减轻，治疗1个月后痊愈，4个月随访，患者身体健康，创面愈合，无瘢痕生长。
烧伤典型案例：
屈某，女，45岁，安徽省蚌埠市人，被炮竹炸伤手臂与背部，经清创消毒后将实施例1提供的贴膏贴在患处，10分钟后疼痛明显减轻，治疗一个月后痊愈，3个月随访，患者身体健康，创面愈合无瘢痕生长。
许某某，男，61岁，安徽省蚌埠市人，被家中柴火烧伤手臂与颈部，经清创消毒后将实施例1提供的贴膏贴在患处，12分钟后疼痛明显减轻，坚持治疗2个月后，患者身体健康，创面愈合无瘢痕生长。
临床观察情况：治疗2天时仅一例病患有明显炎症反应，有中量分泌物，痂下积脓、无创面出血、坏死及上皮组织生长停滞等现象，五例病患有轻微的炎症反应，有少量分泌物，未发现痂下积脓、创面出血、坏死及上皮组织生长停滞等现象，但7天后所有病患创面均无分泌物产生且创面干净有明显的肉芽组织生长。
综上所述，根据本发明外用药物的临床疗效和安全性与临床疗效观察，在84例病患中治愈78例，占92.8％，好转6例，占7.2％，总有效率100％。本发明提供的专门治疗烧烫伤的药膏，可以到达去腐生肌、消炎止痛、抗菌消炎、活血化瘀的功效，且疗程短、见效快，不会引起不良反应、敷贴创口周围的瘙痒与刺痛。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。
Claims (7)
1.一种用于治疗烧烫伤的药膏，其特征在于，按质量份包括以下组分：90-100份花生油、180-200份蜂蜡、20-30份石膏、20-30份黄柏、20-30份丹参、10-15份黄芩、25-30份苦参、20-30份紫草、20-30份益母草、20-30份芦荟、20-30份黄连、10-15份白花蛇舌草、10-15份珍珠母、30-40份甲壳质、20-30份姜黄、10-15份椒棘豆。
2.根据权利要求1所述的一种用于治疗烧烫伤的药膏，其特征在于，按质量份包括以下组分：100份花生油、180份蜂蜡、20份石膏、20份黄柏、20份丹参、10份黄芩、25份苦参、20份紫草、20份益母草、20份芦荟、20份黄连、10份白花蛇舌草、10份珍珠母、30份甲壳质、20份姜黄、10份椒棘豆。
3.根据权利要求1所述的一种用于治疗烧烫伤的药膏，其特征在于，按质量份包括以下组分：100份花生油、180份蜂蜡、24份石膏、23份黄柏、24份丹参、13份黄芩、25份苦参、23份紫草、24份益母草、24份芦荟、22份黄连、13份白花蛇舌草、12份珍珠母、34份甲壳质、23份姜黄、12份椒棘豆。
4.一种药膏的制备方法，其特征在于，用于制备权利要求1-3任意一项所述的一种用于治疗烧烫伤的药膏，包括以下步骤：
S1.预处理：将紫草洗净备用，将其他药物饮片用水洗净过滤后放在煎药锅，加入水和饮片相平，开始用文火烧制水温至70-90℃；
S2.煎制：当S1预处理药物饮片变软至水分全部浸入饮片后将花生油加入S1中的煎药锅，武火烧制油温200-260℃煎制直至油由浑浊变成本色，饮片含水量达到45-55％；
S3.浓缩：将紫草放入S2煎制药物饮片完成的煎药锅中，再改文火烧制油温150-200℃观察，当紫草变焦、饮片变黄，即可离火过滤到容器中；
S4.药膏制备：将蜂蜡与甲壳质熔化过滤倒入步骤S3所述容器中开始搅拌并在搅拌过程中加入芦荟与珍珠母粉，直至成膏。
5.根据权利要求4所述的一种用于治疗烧烫伤的药膏的制备方法，其特征在于，步骤S1与S3中，所述文火温度为：70-90℃。
6.根据权利要求4所述的一种用于治疗烧烫伤的药膏的制备方法，其特征在于，步骤S2中，所述武火温度为：150-200℃。
7.根据权利要求4所述的一种用于治疗烧烫伤的药膏的制备方法，其特征在于，步骤S4中，所述过滤步骤所用的滤网目数为50-80目。
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