CN116887854A - Omni-103 crispr核酸酶 - Google Patents

Omni-103 crispr核酸酶 Download PDF

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Publication number
CN116887854A
CN116887854A CN202280013312.9A CN202280013312A CN116887854A CN 116887854 A CN116887854 A CN 116887854A CN 202280013312 A CN202280013312 A CN 202280013312A CN 116887854 A CN116887854 A CN 116887854A
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China
Prior art keywords
sequence
composition
seq
tracrrna
rna
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Pending
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CN202280013312.9A
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English (en)
Chinese (zh)
Inventor
利奥尔·以斯哈
纳达夫·马巴赫·巴尔
利亚特·洛克
努里特·梅隆
俄斐·阿迪夫·塔尔
阿里尔·吉斯潘
伊迪特·布赫
尼尔·赫克特
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Emmendo Biology
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Emmendo Biology
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Priority claimed from PCT/US2022/015504 external-priority patent/WO2022170199A2/en
Publication of CN116887854A publication Critical patent/CN116887854A/zh
Pending legal-status Critical Current

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Cell Biology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN202280013312.9A 2021-02-08 2022-02-07 Omni-103 crispr核酸酶 Pending CN116887854A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63/147,166 2021-02-08
US63/214,506 2021-06-24
US202163286855P 2021-12-07 2021-12-07
US63/286,855 2021-12-07
PCT/US2022/015504 WO2022170199A2 (en) 2021-02-08 2022-02-07 Omni-103 crispr nuclease

Publications (1)

Publication Number Publication Date
CN116887854A true CN116887854A (zh) 2023-10-13

Family

ID=86731282

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202280013312.9A Pending CN116887854A (zh) 2021-02-08 2022-02-07 Omni-103 crispr核酸酶
CN202280090982.0A Pending CN118660967A (zh) 2021-12-07 2022-12-06 Omni-103 crispr核酸酶-rna复合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202280090982.0A Pending CN118660967A (zh) 2021-12-07 2022-12-06 Omni-103 crispr核酸酶-rna复合物

Country Status (9)

Country Link
US (1) US20250034596A1 (https=)
EP (1) EP4444876A2 (https=)
JP (1) JP2024545144A (https=)
KR (1) KR20240135610A (https=)
CN (2) CN116887854A (https=)
AU (1) AU2022405520A1 (https=)
CA (1) CA3240329A1 (https=)
IL (1) IL313397A (https=)
WO (1) WO2023107946A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024506608A (ja) 2021-02-08 2024-02-14 エメンドバイオ・インコーポレイテッド Ｏｍｎｉ－１０３ ｃｒｉｓｐｒヌクレアーゼ
US12091688B2 (en) 2021-02-08 2024-09-17 Emendobio Inc. OMNI-103 CRISPR nuclease
CN120837655A (zh) * 2025-09-24 2025-10-28 中国人民解放军军事科学院军事医学研究院 磷酸化抑制工具在制备预防和/或治疗三阴性乳腺癌的药物中的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020069029A1 (en) * 2018-09-26 2020-04-02 Emendobio Inc. Novel crispr nucleases
IL298577A (en) * 2020-05-27 2023-01-01 Emendobio Inc Biallelic silencing of sarm1

Also Published As

Publication number Publication date
KR20240135610A (ko) 2024-09-11
WO2023107946A3 (en) 2023-08-03
IL313397A (en) 2024-08-01
CN118660967A (zh) 2024-09-17
EP4444876A2 (en) 2024-10-16
US20250034596A1 (en) 2025-01-30
WO2023107946A2 (en) 2023-06-15
AU2022405520A1 (en) 2024-07-04
CA3240329A1 (en) 2023-06-15
JP2024545144A (ja) 2024-12-05

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