KR20240135610A - Omni-103 crispr 뉴클레아제-rna 복합체 - Google Patents

Omni-103 crispr 뉴클레아제-rna 복합체 Download PDF

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Publication number
KR20240135610A
KR20240135610A KR1020247022561A KR20247022561A KR20240135610A KR 20240135610 A KR20240135610 A KR 20240135610A KR 1020247022561 A KR1020247022561 A KR 1020247022561A KR 20247022561 A KR20247022561 A KR 20247022561A KR 20240135610 A KR20240135610 A KR 20240135610A
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sequence
composition according
tracrrna
seq
rna molecule
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Korean (ko)
Inventor
리오르 이자르
리아트 록카
바르 나다브 마르바흐
니르 헥트
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에멘도바이오 인코포레이티드
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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KR1020247022561A 2021-12-07 2022-12-06 Omni-103 crispr 뉴클레아제-rna 복합체 Pending KR20240135610A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163286855P 2021-12-07 2021-12-07
US63/286,855 2021-12-07
PCT/US2022/081019 WO2023107946A2 (en) 2021-12-07 2022-12-06 Omni-103 crispr nuclease-rna complexes

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KR20240135610A true KR20240135610A (ko) 2024-09-11

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KR1020247022561A Pending KR20240135610A (ko) 2021-12-07 2022-12-06 Omni-103 crispr 뉴클레아제-rna 복합체

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US (1) US20250034596A1 (https=)
EP (1) EP4444876A2 (https=)
JP (1) JP2024545144A (https=)
KR (1) KR20240135610A (https=)
CN (2) CN116887854A (https=)
AU (1) AU2022405520A1 (https=)
CA (1) CA3240329A1 (https=)
IL (1) IL313397A (https=)
WO (1) WO2023107946A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024506608A (ja) 2021-02-08 2024-02-14 エメンドバイオ・インコーポレイテッド Ｏｍｎｉ－１０３ ｃｒｉｓｐｒヌクレアーゼ
US12091688B2 (en) 2021-02-08 2024-09-17 Emendobio Inc. OMNI-103 CRISPR nuclease
CN120837655A (zh) * 2025-09-24 2025-10-28 中国人民解放军军事科学院军事医学研究院 磷酸化抑制工具在制备预防和/或治疗三阴性乳腺癌的药物中的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020069029A1 (en) * 2018-09-26 2020-04-02 Emendobio Inc. Novel crispr nucleases
IL298577A (en) * 2020-05-27 2023-01-01 Emendobio Inc Biallelic silencing of sarm1

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Publication number Publication date
WO2023107946A3 (en) 2023-08-03
IL313397A (en) 2024-08-01
CN118660967A (zh) 2024-09-17
EP4444876A2 (en) 2024-10-16
US20250034596A1 (en) 2025-01-30
CN116887854A (zh) 2023-10-13
WO2023107946A2 (en) 2023-06-15
AU2022405520A1 (en) 2024-07-04
CA3240329A1 (en) 2023-06-15
JP2024545144A (ja) 2024-12-05

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