CN116870102A - Traditional Chinese medicine composition for reducing blood sugar and application thereof - Google Patents

Traditional Chinese medicine composition for reducing blood sugar and application thereof Download PDF

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Publication number
CN116870102A
CN116870102A CN202310933673.1A CN202310933673A CN116870102A CN 116870102 A CN116870102 A CN 116870102A CN 202310933673 A CN202310933673 A CN 202310933673A CN 116870102 A CN116870102 A CN 116870102A
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parts
traditional chinese
chinese medicine
aspongopus
hypoglycemic
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王海平
杜阳
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Beijing Lisheng Hongji Information Technology Development Co ltd
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Beijing Lisheng Hongji Information Technology Development Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/586Turtles; Tortoises, e.g. terrapins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The application relates to a traditional Chinese medicine composition for reducing blood sugar and application thereof, and relates to the technical field of traditional Chinese medicines, wherein the traditional Chinese medicine composition for reducing blood sugar comprises the following components in parts by weight: 40-60 parts of tortoise plastron, 40-60 parts of medlar, 30-40 parts of aspongopus, 15-25 parts of semen astragali complanati, 5-15 parts of mulberry, 5-15 parts of ginseng, 5-20 parts of hawthorn and 5-20 parts of corn silk. The application provides a blood sugar-reducing traditional Chinese medicine composition containing aspongopus, and the components of the traditional Chinese medicine composition are mutually cooperated and act together to ensure that the traditional Chinese medicine composition has remarkable blood sugar-reducing effect, can effectively treat and/or prevent diabetes mellitus, provides a new path for the treatment of diabetics, and has practical application value.

Description

Traditional Chinese medicine composition for reducing blood sugar and application thereof
Technical Field
The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for reducing blood sugar and application thereof.
Background
Diabetes is a metabolic disease characterized by hyperglycemia due to relative insulin deficiency or insulin resistance. The diabetes patients have fat and protein metabolism disorder, and clinically can show the symptoms of diuresis, polydipsia, emaciation and the like, and the long-term hyperglycemia is easy to cause acute complications such as ketoacidosis and the like or chronic complications such as blood vessels, nerves and the like. Among them, type ii diabetes is the most common type of diabetes, and its occurrence and development are related to various factors such as insulin resistance, obesity, or impaired beta cell function.
The existing treatment of diabetes mainly controls blood sugar and reduces complications. The hypoglycemic medicine mainly comprises oral western medicines hypoglycemic medicine and injection insulin analogues, but the sustained administration is required, and the side effect of the medicine is obvious. Therefore, in recent years, the adoption of traditional Chinese medicine treatment has become an important choice for treating diabetes, but at present, a traditional Chinese medicine formula with ideal blood glucose reducing effect is still lacking.
Disclosure of Invention
In order to solve the problems, the application provides a traditional Chinese medicine composition for reducing blood sugar and application thereof, and the traditional Chinese medicine composition has remarkable blood sugar reducing effect and can effectively treat and/or prevent diabetes.
In a first aspect, the application provides a traditional Chinese medicine composition for reducing blood sugar, which comprises the following components in parts by weight:
40-60 parts of tortoise plastron, 40-60 parts of medlar, 30-40 parts of aspongopus, 15-25 parts of semen astragali complanati, 5-15 parts of mulberry, 5-15 parts of ginseng, 5-20 parts of hawthorn and 5-20 parts of corn silk.
Further, the traditional Chinese medicine composition for reducing blood sugar comprises the following components in parts by weight:
45-55 parts of tortoise plastron, 45-55 parts of medlar, 35-40 parts of aspongopus, 20-25 parts of semen astragali complanati, 5-10 parts of mulberry, 5-10 parts of ginseng, 10-20 parts of hawthorn and 15-20 parts of corn silk.
Further, the traditional Chinese medicine composition for reducing blood sugar comprises the following components in parts by weight:
50 parts of tortoise plastron, 50 parts of medlar, 37 parts of aspongopus, 22 parts of aspongopus, 20 parts of semen astragali complanati, 10 parts of mulberry, 10 parts of ginseng, 20 parts of hawthorn and 18 parts of corn silk.
In a second aspect, the application provides an application of the hypoglycemic Chinese medicinal composition in any one of the first aspect in preparing hypoglycemic products.
In a third aspect, the application provides a traditional Chinese medicine honeyed pill for reducing blood sugar, and the functional components of the traditional Chinese medicine honeyed pill for reducing blood sugar comprise the traditional Chinese medicine composition for reducing blood sugar in any one of the first aspect.
Further, the preparation method of the traditional Chinese medicine honeyed pill for reducing blood sugar comprises the following steps:
decalcification treatment is carried out on tortoise plastron, and enzymolysis is carried out to obtain tortoise plastron protein extract;
carrying out supercritical extraction on the aspongopus to obtain aspongopus extract;
extracting fructus Lycii, herba Aspongopus, semen astragali Complanati, mori fructus, ginseng radix, fructus crataegi and stigma Maydis with water to obtain mixed extract;
mixing and sieving the tortoise plastron protein extract, the aspongopus extract and the mixed extract, adding the mixture into honey, stirring, and preparing the traditional Chinese medicine honeyed pill for reducing blood sugar.
Further, the steps of decalcification treatment of tortoise plastron and enzymolysis to obtain tortoise plastron protein extract comprise the following steps:
crushing tortoise plastron, adding the crushed tortoise plastron into 0.5-1.0 mol/L ethylenediamine tetraacetic acid, and stirring for 1-3 hours to obtain a first reaction feed liquid;
adding 0.8-1.2 mol/L alkali liquor into the first reaction feed liquor, stirring for 4-7 hours, and then centrifugally filtering and washing to obtain decalcified tortoise plastron solids;
adding the decalcified tortoise plastron solid into water for cooking for 1-3 hours, cooling to room temperature, and adding trypsin with the enzyme amount of 2-3 ten thousand U for enzymolysis for 5-8 hours to obtain the tortoise plastron protein extract.
Further, the working parameters of the supercritical extraction include: the solvent is supercritical carbon dioxide fluid, the pressure is 40-50 Mpa, the temperature is 45-55 ℃ and the time is 1-2 hours.
Further, the step of extracting the wolfberry fruit, the murraya paniculata, the semen astragali complanati, the mulberry, the ginseng, the hawthorn and the corn silk with water to obtain a mixed extract comprises the following steps of:
pulverizing fructus Lycii, herba Aspongopus, semen astragali Complanati, mori fructus, ginseng radix, fructus crataegi and stigma Maydis, extracting with 5-8 times of water, concentrating under reduced pressure, and drying to obtain the mixed extract; wherein the extracted working parameters include: the temperature is 100-110 ℃, the time is 1-3 hours, and the times are 1-3 times.
Further, the weight ratio of the hypoglycemic Chinese medicinal composition to the honey is 1 (1-2).
Compared with the prior art, the technical scheme provided by the embodiment of the application has at least the following advantages:
the embodiment of the application provides a traditional Chinese medicine composition for reducing blood sugar, in particular to a traditional Chinese medicine composition for reducing blood sugar containing aspongopus, which takes tortoise plastron, medlar and aspongopus as monarch drugs and has the effects of nourishing yin, moistening lung, promoting qi circulation and removing deficiency of both yin; takes murraya paniculata and semen astragali Complanati as ministerial drugs, and has the effects of promoting blood circulation, removing blood stasis, tonifying kidney and supporting yang; and mulberry, ginseng, hawthorn and corn silk are matched as adjuvant drugs to promote the production of body fluid, moisten dryness, break qi, remove food retention, strengthen stomach and promote blood circulation. The medicines are combined together, and all the components are mutually cooperated, so that the medicine has remarkable blood sugar reducing effect, can effectively treat and/or prevent diabetes mellitus, provides a new path for treating diabetes mellitus patients (especially type II diabetes mellitus patients), and has practical application value.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more apparent, the technical solutions of the present application will be clearly and completely described in conjunction with the embodiments of the present application, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Unless otherwise specifically indicated, the various raw materials, reagents, instruments, equipment and the like used in the present application are commercially available or may be prepared by existing methods.
In a first aspect, the application provides a traditional Chinese medicine composition for reducing blood sugar, which comprises the following components in parts by weight:
40-60 parts of tortoise plastron, 40-60 parts of medlar, 30-40 parts of aspongopus, 15-25 parts of semen astragali complanati, 5-15 parts of mulberry, 5-15 parts of ginseng, 5-20 parts of hawthorn and 5-20 parts of corn silk.
Tortoise plastron: is prepared from the tortoise shell and the abdominal shell, and has the effects of nourishing yin, suppressing yang, tonifying kidney, strengthening bone, nourishing blood, tonifying heart, and the like.
Wolfberry fruit: is a dried mature fruit of Lycium barbarum of Solanaceae, and has effects of replenishing kidney essence, moistening lung, and nourishing liver.
Aspongopus (L.) kuntze: is the body of Aspongopus of stinkbugaceae, and has effects of activating qi-flowing, relieving pain, warming kidney, and supporting yang.
Murraya paniculata: is prepared from dried leaves and twigs of Murraya koenigii and Murraya koenigii of Rutaceae, and has effects of activating qi-flowing, relieving pain, promoting blood circulation, removing blood stasis, etc.
Semen astragali Complanati: is a dry mature seed of astragalus membranaceus which is a leguminous plant, and has the effects of tonifying kidney, supporting yang, securing essence, reducing urination, nourishing liver, improving eyesight and the like.
Mulberry: is dry fruit ear of Morus alba Linne of Moraceae, and has effects of nourishing yin, replenishing blood, promoting salivation, and moistening dryness.
Ginseng: is prepared from dried root and rhizome of Panax ginseng of Araliaceae, and has effects of invigorating primordial qi, recovering pulse, relieving depletion, invigorating spleen, benefiting lung, promoting salivation, nourishing blood, tranquilizing mind, improving intelligence, etc.
Hawthorn fruit: is a dried and mature fruit of the hawthorn plant, and has the effects of invigorating stomach, promoting digestion, promoting qi circulation, removing blood stasis, resolving turbidity, reducing lipid and the like.
Corn silk: is prepared from the flower column and the column head of maize, which are the gramineous plants, and has the effects of inducing diuresis to alleviate edema, clearing liver-fire, promoting bile flow and the like.
The embodiment of the application provides a traditional Chinese medicine composition for reducing blood sugar, in particular to a traditional Chinese medicine composition for reducing blood sugar containing aspongopus, which takes tortoise plastron, medlar and aspongopus as monarch drugs and has the effects of nourishing yin, moistening lung, promoting qi circulation and removing deficiency of both yin; takes murraya paniculata and semen astragali Complanati as ministerial drugs, and has the effects of promoting blood circulation, removing blood stasis, tonifying kidney and supporting yang; and mulberry, ginseng, hawthorn and corn silk are matched as adjuvant drugs to promote the production of body fluid, moisten dryness, break qi, remove food retention, strengthen stomach and promote blood circulation. The medicines are combined together, and all the components are mutually cooperated, so that the medicine has remarkable blood sugar reducing effect, can effectively treat and/or prevent diabetes mellitus, provides a new path for treating diabetes mellitus patients (especially type II diabetes mellitus patients), and has practical application value.
In some embodiments, the tortoise plastron may be 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts, 60 parts, etc.
In some embodiments, the weight fraction of the wolfberry fruit may be 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, etc.
In some embodiments, the aspongopus may be 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, etc.
In some embodiments, the parts by weight of murraya paniculata may be 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, etc.
In some embodiments, the weight parts of the semen astragali complanati may be 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, etc.
In some embodiments, the mulberry may be 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, etc.
In some embodiments, the ginseng may be 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, etc.
In some embodiments, the weight parts of the hawthorn can be 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, etc.
In some embodiments, the corn silk can be 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, etc.
Preferably, the traditional Chinese medicine composition for reducing blood sugar comprises the following components in parts by weight:
45-55 parts of tortoise plastron, 45-55 parts of medlar, 35-40 parts of aspongopus, 20-25 parts of semen astragali complanati, 5-10 parts of mulberry, 5-10 parts of ginseng, 10-20 parts of hawthorn and 15-20 parts of corn silk.
More preferably, the hypoglycemic traditional Chinese medicine composition comprises the following components in parts by weight:
50 parts of tortoise plastron, 50 parts of medlar, 37 parts of aspongopus, 22 parts of aspongopus, 20 parts of semen astragali complanati, 10 parts of mulberry, 10 parts of ginseng, 20 parts of hawthorn and 18 parts of corn silk.
In some embodiments, the preparation method of the traditional Chinese medicine composition comprises the following steps:
decalcification treatment is carried out on tortoise plastron, and enzymolysis is carried out to obtain tortoise plastron protein extract;
carrying out supercritical extraction on the aspongopus to obtain aspongopus extract;
extracting fructus Lycii, herba Aspongopus, semen astragali Complanati, mori fructus, ginseng radix, fructus crataegi and stigma Maydis with water to obtain mixed extract;
mixing and sieving the tortoise plastron protein extract, the aspongopus extract and the mixed extract to obtain the traditional Chinese medicine composition.
The components of the hypoglycemic Chinese medicinal composition provided by the embodiment of the application can be directly commercially available products if the raw materials are not limited or described in particular.
In a second aspect, based on a general inventive concept, the present application provides a use of the hypoglycemic Chinese medicinal composition according to any one of the first aspect in preparing a hypoglycemic product.
The blood sugar-reducing traditional Chinese medicine composition containing aspongopus, provided by the embodiment of the application, has a remarkable blood sugar-reducing effect, can effectively treat and/or prevent diabetes, provides a new path for treating diabetes patients (especially type II diabetes patients), and has practical application value.
In a third aspect, the application provides a traditional Chinese medicine honeyed pill for reducing blood sugar, and the functional components of the traditional Chinese medicine honeyed pill for reducing blood sugar comprise the traditional Chinese medicine composition for reducing blood sugar in any one of the first aspect.
The embodiment of the application provides a traditional Chinese medicine honeyed pill for reducing blood sugar, which is an oral medicine, can improve the taste of the medicine, is easy to take, can better preserve the effective components of the Chinese herbal medicine, and achieves the optimal treatment effect.
As an implementation mode of the embodiment of the application, the preparation method of the traditional Chinese medicine honeyed pill for reducing blood sugar comprises the following steps:
decalcification treatment is carried out on tortoise plastron, and enzymolysis is carried out to obtain tortoise plastron protein extract;
carrying out supercritical extraction on the aspongopus to obtain aspongopus extract;
extracting fructus Lycii, herba Aspongopus, semen astragali Complanati, mori fructus, ginseng radix, fructus crataegi and stigma Maydis with water to obtain mixed extract;
mixing and sieving the tortoise plastron protein extract, the aspongopus extract and the mixed extract, adding the mixture into honey, stirring, and preparing the traditional Chinese medicine honeyed pill for reducing blood sugar.
The applicant researches find that the specific methods are adopted to extract tortoise plastron, aspongopus, medlar, murraya paniculata, semen astragali complanati, mulberry, ginseng, hawthorn and corn silk respectively, and then honey is added to prepare the honeyed pill, so that the blood sugar reducing effect of the medicament is better.
In some embodiments, the step of decalcifying tortoise plastron and then performing enzymolysis to obtain the tortoise plastron protein extract comprises the following steps:
crushing tortoise plastron, adding the crushed tortoise plastron into 0.5-1.0 mol/L ethylenediamine tetraacetic acid, and stirring for 1-3 hours to obtain a first reaction feed liquid;
adding 0.8-1.2 mol/L alkali liquor into the first reaction feed liquor, stirring for 4-7 hours, and then centrifugally filtering and washing to obtain decalcified tortoise plastron solids;
adding the decalcified tortoise plastron solid into water for cooking for 1-3 hours, cooling to room temperature, and adding trypsin with the enzyme amount of 2-3 ten thousand U for enzymolysis for 5-8 hours to obtain the tortoise plastron protein extract.
In some embodiments, the operating parameters of the supercritical extraction include: the solvent is supercritical carbon dioxide fluid, the pressure is 40-50 Mpa, the temperature is 45-55 ℃ and the time is 1-2 hours.
In some embodiments, the step of extracting the wolfberry fruit, the murraya paniculata, the semen astragali complanati, the mulberry, the ginseng, the hawthorn and the corn silk with water to obtain the mixed extract comprises the following steps:
pulverizing fructus Lycii, herba Aspongopus, semen astragali Complanati, mori fructus, ginseng radix, fructus crataegi and stigma Maydis, extracting with 5-8 times of water, concentrating under reduced pressure, and drying to obtain the mixed extract; wherein the extracted working parameters include: the temperature is 100-110 ℃, the time is 1-3 hours, and the times are 1-3 times.
In some specific embodiments, the process of preparing the honeyed pill by adding honey can be carried out according to the prior art, for example, the honey is weighed according to the weight ratio of the hypoglycemic Chinese medicinal composition to the honey of 1 (1-2), then the honey is heated and boiled for 4-6 minutes, and the honey pill is prepared by adding the honey into medicinal powder prepared by the Chinese medicinal composition, uniformly mixing and cooling. In some specific embodiments, the weight of each hypoglycemic Chinese medicinal honeyed pill is 5-8 g, preferably 6g.
The preparation method of the traditional Chinese medicine honeyed pill for reducing blood sugar provided by the application is simple to operate, does not need extra special equipment, and is suitable for industrial production. Meanwhile, the preparation method of the traditional Chinese medicine honeyed pill for reducing blood sugar is realized based on the traditional Chinese medicine composition for reducing blood sugar in any one of the first aspect, so that the traditional Chinese medicine honeyed pill for reducing blood sugar has at least all the beneficial effects brought by the technical scheme of the embodiment and is not repeated here. The operation steps involved in the preparation method of the traditional Chinese medicine honeyed pill for reducing blood sugar provided by the embodiment of the application can be carried out in a conventional manner in the art without special limitation or explanation, and are not repeated here.
The application will be further illustrated with reference to specific examples. It is to be understood that these examples are illustrative of the present application and are not intended to limit the scope of the present application. The experimental procedures, which are not specified in the following examples, are generally determined according to national standards. If the corresponding national standard does not exist, the method is carried out according to the general international standard, the conventional condition or the condition recommended by the manufacturer.
Example 1
The example provides a traditional Chinese medicine composition for reducing blood sugar, which comprises the following components in parts by weight (1 g in each 1 part by weight): 40 parts of tortoise plastron, 40 parts of medlar, 30 parts of aspongopus, 15 parts of semen astragali complanati, 5 parts of mulberry, 5 parts of ginseng, 5 parts of hawthorn and 5 parts of corn silk.
The preparation method of the traditional Chinese medicine composition for reducing blood sugar comprises the following steps:
grinding 40g of tortoise plastron, sieving with a 50-100 mesh sieve, adding 100mL of ethylenediamine tetraacetic acid with the concentration of 0.7mol/L, stirring for 2 hours, adding excessive sodium hydroxide with the concentration of 1mol/L, continuously stirring for 7 hours, centrifuging, filtering, and washing to obtain a tortoise plastron solid after decalcification treatment; adding the decalcified tortoise plastron solid into 200mL of water, steaming and boiling for 2 hours, cooling to room temperature, and adding trypsin with the enzyme amount of 2.5 ten thousand U to carry out enzymolysis for 7 hours to obtain the tortoise plastron protein extract;
grinding 30g of aspongopus, sieving with a 80-mesh sieve, adding into a supercritical device, performing supercritical extraction, placing the extracted product in an environment of 5 ℃ for 2 hours at constant temperature, centrifuging at 6000r/min for 20 minutes to remove bottom sediment, and vacuumizing the supernatant in a vacuum box at 45 ℃ for 12 hours to obtain aspongopus extract; wherein, the working parameters of the supercritical extraction comprise: the solvent is supercritical carbon dioxide fluid, the pressure is 45Mpa, the temperature is 50 ℃, the time is 1.5 hours, and CO 2 The flow rate of the fluid is 15kg/h;
pulverizing 40g of medlar, 30g of Murraya paniculata, 15g of semen astragali Complanati, 5g of mulberry, 5g of ginseng, 5g of hawthorn and 5g of corn silk, adding water with the weight being 7 times of the total weight of the traditional Chinese medicine raw materials in a water extraction mode for extraction, and concentrating under reduced pressure and drying to constant weight to obtain the mixed extract; wherein the extracted working parameters include: the temperature is 105 ℃, the time is 2 hours, and the times are 1 time;
mixing the tortoise plastron protein extract, the aspongopus extract and the mixed extract, and sieving the mixture with a 50-100-mesh sieve to obtain the traditional Chinese medicine composition for reducing blood sugar.
Example 2
The present example provides a hypoglycemic Chinese medicinal composition, which differs from example 1 only in that: the traditional Chinese medicine composition for reducing blood sugar comprises the following components in parts by weight (1 g in each 1 part by weight): 60 parts of tortoise plastron, 60 parts of medlar, 40 parts of aspongopus, 25 parts of semen astragali complanati, 15 parts of mulberry, 15 parts of ginseng, 20 parts of hawthorn and 20 parts of corn silk; the rest steps and parameters are the same.
Example 3
The present example provides a hypoglycemic Chinese medicinal composition, which differs from example 1 only in that: the traditional Chinese medicine composition for reducing blood sugar comprises the following components in parts by weight (1 g in each 1 part by weight): 45 parts of tortoise plastron, 45 parts of medlar, 35 parts of aspongopus, 20 parts of semen astragali complanati, 5 parts of mulberry, 5 parts of ginseng, 10 parts of hawthorn and 15 parts of corn silk; the rest steps and parameters are the same.
Example 4
The present example provides a hypoglycemic Chinese medicinal composition, which differs from example 1 only in that: the traditional Chinese medicine composition for reducing blood sugar comprises the following components in parts by weight (1 g in each 1 part by weight): 55 parts of tortoise plastron, 55 parts of medlar, 40 parts of aspongopus, 25 parts of semen astragali complanati, 10 parts of mulberry, 10 parts of ginseng, 20 parts of hawthorn and 20 parts of corn silk; the rest steps and parameters are the same.
Example 5
The present example provides a hypoglycemic Chinese medicinal composition, which differs from example 1 only in that: the traditional Chinese medicine composition comprises, by weight, 50 parts of tortoise plastron, 50 parts of medlar, 37 parts of aspongopus, 22 parts of aspongopus, 20 parts of semen astragali complanati, 10 parts of mulberry, 10 parts of ginseng, 20 parts of hawthorn and 18 parts of corn silk; the rest steps and parameters are the same.
Comparative example 1
The present example provides a hypoglycemic Chinese medicinal composition, which differs from example 5 only in that: the dosage of the aspongopus is adjusted to 20 parts; the rest steps and parameters are the same.
Comparative example 2
The present example provides a hypoglycemic Chinese medicinal composition, which differs from example 5 only in that: the dosage of the aspongopus is adjusted to 50 parts; the rest steps and parameters are the same.
Comparative example 3
The present example provides a hypoglycemic Chinese medicinal composition, which differs from example 5 only in that: the method for extracting the aspongopus by adopting the water extraction method comprises the following specific processes: grinding Aspongopus, sieving with a 50-100 mesh sieve, adding 7 times of water for extraction, concentrating under reduced pressure, and drying to constant weight to obtain Aspongopus extract; wherein the extracted working parameters include: the temperature is 105 ℃, the time is 2 hours, and the times are 1 time; the rest steps and parameters are the same.
Comparative example 4
The present example provides a hypoglycemic Chinese medicinal composition, which differs from example 5 only in that: extracting tortoise plastron by adopting a water extraction mode, wherein the specific process is as follows: grinding tortoise plastron, sieving with a 50-100 mesh sieve, adding water with the weight being 7 times of that of the tortoise plastron, extracting, concentrating under reduced pressure, and drying to constant weight to obtain the aspongopus extract; wherein the extracted working parameters include: the temperature is 105 ℃, the time is 2 hours, and the times are 1 time; the rest steps and parameters are the same.
Test case
This example demonstrates the efficacy of the hypoglycemic Chinese medicinal compositions provided in examples 1 to 5 and comparative examples 1 to 4.
The testing method and the grouping are as follows: 120 were used: SPF-class C57BL/6J male mice are randomly divided into 12 groups, namely a blank group (1 group; not molded), a model group (1 group; molded, not administered), a positive control group (1 group; molded, administered with commercial rosiglitazone sodium tablet at 5 mg/kg/day, and administered by intragastric administration), and a hypoglycemic Chinese medicinal composition group (9 group; molded, numbered 1 st to 11 hypoglycemic Chinese medicinal composition groups; 1 st to 5 th hypoglycemic Chinese medicinal composition groups are sequentially administered with hypoglycemic Chinese medicinal compositions provided in examples 1 to 5 respectively, and 6 th to 9 th hypoglycemic Chinese medicinal compositions are sequentially administered with hypoglycemic Chinese medicinal compositions provided in comparative examples 1 to 4 respectively, and the administration amounts are 50 mg/kg/day, and administered by intragastric administration). The positive control group and the hypoglycemic Chinese medicinal composition group are administered by gastric lavage for 1 time a day for 30 days continuously, and the blank blood sugar value and body weight of the mice are measured.
The molding method comprises the following steps: the mice are fasted for 24 hours (free drinking water), the molding is carried out by injecting the tetraoxypyrimidine into the abdominal cavity for 130mg/kg, and after the free diet for 7 days, the fasting blood glucose value is measured, and the blood glucose value is more than 10mmol/L, thus the molding is carried out successfully.
The test results are shown in Table 1.
TABLE 1
As can be seen from Table 1, the hypoglycemic effects of the hypoglycemic Chinese medicinal compositions provided in examples 1 to 5 are better than those of comparative examples 1 to 4, and the hypoglycemic effects of the hypoglycemic Chinese medicinal compositions provided in examples 1 to 5 provided in example 5 are optimal.
Application example
In the embodiment, the hypoglycemic Chinese medicinal composition provided in the embodiment 5 is prepared into honeyed pills and then applied to treating diabetics.
The preparation process of the traditional Chinese medicine honeyed pill comprises the following steps: weighing the traditional Chinese medicine composition for reducing blood sugar and honey according to the ratio of 1:1, heating and boiling the honey for 4-6 minutes, adding the honey into medicinal powder prepared by the traditional Chinese medicine composition, uniformly mixing, cooling and preparing into traditional Chinese medicine honeyed pills with the concentration of 6 g/granule.
Diabetes patient information: men, 41 years old, were diagnosed with type ii diabetes. Before treatment, the fasting blood glucose detection value is 19.53mmol/L, and the hypoglycemic traditional Chinese medicine composition provided in the example 5 is taken to prepare honeyed pills, each time in the morning and evening, 5 pills are taken for 1 month, and the fasting blood glucose detection value is 5.08mmol/L, so that the normal standard is restored.
In summary, the embodiment of the application provides a traditional Chinese medicine composition for reducing blood sugar, in particular to a traditional Chinese medicine composition for reducing blood sugar containing aspongopus, which has obvious blood sugar reducing effect due to mutual cooperation and combined action of all the components, can effectively treat and/or prevent diabetes, provides a new path for treatment of diabetics, and has practical application value.
The foregoing is only a specific embodiment of the application to enable those skilled in the art to understand or practice the application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (10)

1. The traditional Chinese medicine composition for reducing blood sugar is characterized by comprising the following components in parts by weight:
40-60 parts of tortoise plastron, 40-60 parts of medlar, 30-40 parts of aspongopus, 15-25 parts of semen astragali complanati, 5-15 parts of mulberry, 5-15 parts of ginseng, 5-20 parts of hawthorn and 5-20 parts of corn silk.
2. The hypoglycemic traditional Chinese medicine composition according to claim 1, wherein the hypoglycemic traditional Chinese medicine composition comprises the following components in parts by weight:
45-55 parts of tortoise plastron, 45-55 parts of medlar, 35-40 parts of aspongopus, 20-25 parts of semen astragali complanati, 5-10 parts of mulberry, 5-10 parts of ginseng, 10-20 parts of hawthorn and 15-20 parts of corn silk.
3. The hypoglycemic traditional Chinese medicine composition according to claim 1, wherein the hypoglycemic traditional Chinese medicine composition comprises the following components in parts by weight:
50 parts of tortoise plastron, 50 parts of medlar, 37 parts of aspongopus, 22 parts of aspongopus, 20 parts of semen astragali complanati, 10 parts of mulberry, 10 parts of ginseng, 20 parts of hawthorn and 18 parts of corn silk.
4. Use of a hypoglycemic Chinese medicinal composition according to any one of claims 1-3 in the preparation of a hypoglycemic product.
5. The traditional Chinese medicine honeyed pill for reducing blood sugar is characterized in that the functional components of the traditional Chinese medicine honeyed pill for reducing blood sugar comprise the traditional Chinese medicine composition for reducing blood sugar according to any one of claims 1-3.
6. The hypoglycemic traditional Chinese medicine honeyed pill according to claim 5, wherein the preparation method of the hypoglycemic traditional Chinese medicine honeyed pill comprises the following steps:
decalcification treatment is carried out on tortoise plastron, and enzymolysis is carried out to obtain tortoise plastron protein extract;
carrying out supercritical extraction on the aspongopus to obtain aspongopus extract;
extracting fructus Lycii, herba Aspongopus, semen astragali Complanati, mori fructus, ginseng radix, fructus crataegi and stigma Maydis with water to obtain mixed extract;
mixing and sieving the tortoise plastron protein extract, the aspongopus extract and the mixed extract, adding the mixture into honey, stirring, and preparing the traditional Chinese medicine honeyed pill for reducing blood sugar.
7. The hypoglycemic Chinese medicinal honeyed pill according to claim 6, wherein the step of performing decalcification treatment and enzymolysis on tortoise plastron to obtain tortoise plastron protein extract comprises the following steps of:
crushing tortoise plastron, adding the crushed tortoise plastron into 0.5-1.0 mol/L ethylenediamine tetraacetic acid, and stirring for 1-3 hours to obtain a first reaction feed liquid;
adding 0.8-1.2 mol/L alkali liquor into the first reaction feed liquor, stirring for 4-7 hours, and then centrifugally filtering and washing to obtain decalcified tortoise plastron solids;
adding the decalcified tortoise plastron solid into water for cooking for 1-3 hours, cooling to room temperature, and adding trypsin with the enzyme amount of 2-3 ten thousand U for enzymolysis for 5-8 hours to obtain the tortoise plastron protein extract.
8. The hypoglycemic Chinese medicinal honeyed pill according to claim 6, wherein the working parameters of supercritical extraction comprise: the solvent is supercritical carbon dioxide fluid, the pressure is 40-50 Mpa, the temperature is 45-55 ℃ and the time is 1-2 hours.
9. The hypoglycemic Chinese medicinal honeyed pill according to claim 6, wherein the step of extracting wolfberry fruit, murraya paniculata, semen astragali complanati, mulberry, ginseng, hawthorn and corn silk with water to obtain a mixed extract comprises:
pulverizing fructus Lycii, herba Aspongopus, semen astragali Complanati, mori fructus, ginseng radix, fructus crataegi and stigma Maydis, extracting with 5-8 times of water, concentrating under reduced pressure, and drying to obtain the mixed extract; wherein the extracted working parameters include: the temperature is 100-110 ℃, the time is 1-3 hours, and the times are 1-3 times.
10. The hypoglycemic Chinese medicinal honeyed pill according to claim 6, wherein the weight ratio of the hypoglycemic Chinese medicinal composition to the honey is 1 (1-2).
CN202310933673.1A 2023-07-27 2023-07-27 Traditional Chinese medicine composition for reducing blood sugar and application thereof Pending CN116870102A (en)

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