CN116869162A - Health product for improving immunity by using glehnia littoralis and preparation method thereof - Google Patents
Health product for improving immunity by using glehnia littoralis and preparation method thereof Download PDFInfo
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- CN116869162A CN116869162A CN202310582975.9A CN202310582975A CN116869162A CN 116869162 A CN116869162 A CN 116869162A CN 202310582975 A CN202310582975 A CN 202310582975A CN 116869162 A CN116869162 A CN 116869162A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention discloses a health product for improving immunity by using glehnia littoralis and a preparation method thereof, and the health product is prepared from the following raw materials in parts by weight: 2-25 parts of rhizoma Panacis Japonici, 5-30 parts of radix Pseudostellariae, 10-35 parts of radix Glehniae, 10-15 parts of fructus Lycii, 15-20 parts of fructus Jujubae, 15-20 parts of longan, 10-15 parts of cortex Cinnamomi and 10-20 parts of Coicis semen. The health food composition is prepared by decocting rhizoma Panacis Japonici, radix Pseudostellariae and radix Glehniae, centrifuging at high speed, vacuum concentrating, drying, adding conventional adjuvants, and making into granule, hard capsule or tablet. The traditional Chinese medicine is green, healthy, environment-friendly, free of toxic and side effects, quick in drug effect absorption, high in utilization rate and remarkable in effect, and adopts the green purely natural traditional Chinese medicine as the main raw material. The preparation method provided by the invention is simple and convenient to operate and suitable for industrial production.
Description
Technical Field
The invention relates to the technical field of health products, in particular to a health product for improving immunity by using glehnia littoralis and a preparation method thereof.
Background
Currently, human immunity is the ability of people to resist the environment and viruses. The body of the patient is affected by bacteria and viruses every moment, and the normal immunity can help the patient resist the invasion of foreign matters, so that the body is in a relatively stable and dynamic balance state, the self-healing force of the body is ensured to be exerted, and the body of the patient is prevented from suffering from diseases.
The body with low immunity is susceptible to infection or cancer, such as allergic reactions, autoimmune diseases, etc. The immune system cannot normally play a protective role due to various reasons, and in this case, infections such as bacteria, viruses and fungi are extremely liable to occur, so that the most direct manifestation of low immunity is easy to be ill. Because of frequent illness and aggravated consumption of organisms, the health and weakness, malnutrition, listlessness, fatigue and weakness, appetite reduction, sleep disturbance and other manifestations are common, and the medical injection and medication are convenient for family use. Each illness takes a long time to recover and often recurs. Long-term development of physical and mental retardation and susceptibility to serious diseases. The deep cause is hypoimmunity or poor immunity. When the immune function of the human body is disturbed, or the immune system is not sound, the following problems are repeated: recurrent cold attacks, recurrent tonsillitis attacks, recurrent asthma attacks, recurrent bronchitis attacks, recurrent pneumonia attacks, recurrent diarrhea attacks. Especially for the elderly and children, and for patients with primary and secondary diseases, and for patients with cancer after radiotherapy and chemotherapy, the composition has weak autoimmune power, and is easy to infect virus and bacteria. Although many medicines for improving immunity exist at present, the effects are not ideal, some of the medicines are poor in absorption effect, some of the medicines are too expensive, some of the medicines contain additives for inducing side effects, and the demands of consumers cannot be met well.
Disclosure of Invention
In order to achieve the above purpose, the present invention provides the following technical solutions: a health care product for improving immunity by using glehnia littoralis is prepared from the following raw materials in parts by weight: 2-25 parts of rhizoma Panacis Japonici, 5-30 parts of radix Pseudostellariae, 10-35 parts of radix Glehniae, 10-15 parts of fructus Lycii, 15-20 parts of fructus Jujubae, 15-20 parts of longan, 10-15 parts of cortex Cinnamomi and 10-20 parts of Coicis semen.
As a preferable technical mode of the invention, the health care product is prepared from the following raw materials in parts by weight: 10 parts of panax japonicus, 20 parts of radix pseudostellariae, 15 parts of radix glehniae, 10 parts of medlar, 15 parts of red dates, 18 parts of longan, 12 parts of cinnamon and 15 parts of pearl barley.
As a preferable technical mode of the invention, the health care product is prepared from the following raw materials in parts by weight: 10 parts of panax japonicus, 25 parts of radix pseudostellariae, 35 parts of radix glehniae, 12 parts of medlar, 18 parts of red dates, 18 parts of longan, 12 parts of cinnamon and 15 parts of pearl barley.
As a preferred technical mode of the invention, the preparation method comprises the following preparation steps:
(1) Mixing: uniformly mixing the rhizoma Panacis Japonici, radix Pseudostellariae, radix Glehniae, fructus Lycii, fructus Jujubae, arillus longan, cortex Cinnamomi and Coicis semen at a certain ratio to obtain mixed powder;
(2) Softening: mixing the mixed powder with alcohol to obtain softened mixed powder;
(3) Granulating: granulating the softened mixed powder through a granulator to obtain granular mixed powder;
(4) And (3) drying: drying the granular mixed powder by a dryer to obtain finished granular mixed powder;
(5) Mixing and tabletting: uniformly mixing the finished particle mixed powder and magnesium stearate powder to obtain a total mixture, and tabletting the total mixture to obtain tablet cores; and coating to obtain the finished product.
As a preferable technical mode of the invention, the panax japonicus, the radix pseudostellariae and the radix glehniae are soaked in water for 2 hours before mixing, decocted for 2 times, 1.5 hours each time, the water addition amount is 10 times and 8 times respectively, the decocted liquid is centrifuged at high speed for half an hour at 3500-5000 revolutions, vacuum drying (the temperature is less than or equal to 70 ℃), and the dried paste is crushed and then sieved by a sieve of 80 meshes.
Compared with the prior art, the invention has the following beneficial effects:
the health food composition is prepared by decocting rhizoma Panacis Japonici, radix Pseudostellariae and radix Glehniae, centrifuging at high speed, vacuum concentrating, drying, adding conventional adjuvants, and making into granule, hard capsule or tablet. The traditional Chinese medicine is green, healthy, environment-friendly, free of toxic and side effects, quick in drug effect absorption, high in utilization rate and remarkable in effect, and adopts the green purely natural traditional Chinese medicine as the main raw material. The preparation method provided by the invention is simple and convenient to operate and suitable for industrial production.
Detailed Description
The invention is further described in connection with the following detailed description, in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the invention easy to understand.
A health care product for improving immunity by using glehnia littoralis is prepared from the following raw materials in parts by weight: 2-25 parts of rhizoma Panacis Japonici, 5-30 parts of radix Pseudostellariae, 10-35 parts of radix Glehniae, 10-15 parts of fructus Lycii, 15-20 parts of fructus Jujubae, 15-20 parts of longan, 10-15 parts of cortex Cinnamomi and 10-20 parts of Coicis semen.
As a preferable technical mode of the invention, the health care product is prepared from the following raw materials in parts by weight: 10 parts of panax japonicus, 20 parts of radix pseudostellariae, 15 parts of radix glehniae, 10 parts of medlar, 15 parts of red dates, 18 parts of longan, 12 parts of cinnamon and 15 parts of pearl barley.
As a preferable technical mode of the invention, the health care product is prepared from the following raw materials in parts by weight: 10 parts of panax japonicus, 25 parts of radix pseudostellariae, 35 parts of radix glehniae, 12 parts of medlar, 18 parts of red dates, 18 parts of longan, 12 parts of cinnamon and 15 parts of pearl barley.
As a preferred technical mode of the invention, the preparation method comprises the following preparation steps:
(1) Mixing: uniformly mixing the rhizoma Panacis Japonici, radix Pseudostellariae, radix Glehniae, fructus Lycii, fructus Jujubae, arillus longan, cortex Cinnamomi and Coicis semen at a certain ratio to obtain mixed powder;
(2) Softening: mixing the mixed powder with alcohol to obtain softened mixed powder;
(3) Granulating: granulating the softened mixed powder through a granulator to obtain granular mixed powder;
(4) And (3) drying: drying the granular mixed powder by a dryer to obtain finished granular mixed powder;
(5) Mixing and tabletting: uniformly mixing the finished particle mixed powder and magnesium stearate powder to obtain a total mixture, and tabletting the total mixture to obtain tablet cores; and coating to obtain the finished product.
As a preferable technical mode of the invention, the panax japonicus, the radix pseudostellariae and the radix glehniae are soaked in water for 2 hours before mixing, decocted for 2 times, 1.5 hours each time, the water addition amount is 10 times and 8 times respectively, the decocted liquid is centrifuged at high speed for half an hour at 3500-5000 revolutions, vacuum drying (the temperature is less than or equal to 70 ℃), and the dried paste is crushed and then sieved by a sieve of 80 meshes.
The glehnia root in the invention is the root of glehnia root of the umbrella plant. The radix Glehniae perennial herb is planted in coast sand, beach or loose sandy soil, and is distributed in Shandong, liaoning, inner Mongolia (HemiFeng), hebei, jiangsu, zhejiang, fujian, guangdong, etc. Preferably, the root of the autumn ginseng is dug, the overground part and fibrous root are removed, the mixture is cleaned, the mixture is scalded by boiled water, the crust is peeled off, and the mixture is dried in the sun or with slow fire; then removing the rough part and bundling. Or cleaning and directly sun drying.
Radix Glehniae is in the shape of slender cylinder, and has branches, 15-45 cm long and 0.2-1.5 cm diameter. The surface is yellowish, slightly rough, and has residual crust, and the surface of the crust is not yellow brown. The whole has fine wrinkles and longitudinal furrows, and brown yellow punctiform fine root marks. The yellow brown rhizome is left at the top end, the upper end is slightly thinner, the middle part is slightly thicker, and the lower part is thinner. The skin of the section is light yellow and white. Woody yellow. Specific smell, slightly sweet taste. It is preferable to remove the skin of the embolus with uniform thickness and yellowish white color.
Radix Glehniae contains volatile oil, coumarin, starch, alkaloid, triterpenic acid, stigmasterol, sterols, and radix Adenophorae extract. Experiments prove that the glehnia littoralis can improve the T cell ratio, improve the lymphocyte conversion rate, improve the white blood cells, enhance the macrophage function, prolong the antibody existence time, improve the B cells and promote the immune function. Radix Glehniae can strengthen vital qi, reduce diseases, and prevent cancer. Radix glehniae is sweet in taste, slightly bitter in flavor and slightly cold in nature; it has effects of nourishing yin, clearing lung-heat, invigorating stomach and promoting fluid production. Is mainly used for treating dry cough with little phlegm, dry throat and nose, cough with blood due to deficiency of lung yin, thirst and dry tongue due to heat injury of stomach yin, and inappetence.
Experiment: influence of glehnia root health care product on immunity of mice
32 male Kunming mice were purchased and randomly divided into 4 groups, namely a blank group, a high dose group (0.9 g/kg), a medium dose group (0.6 g/kg), a low dose group (0.3 g/kg), and 4 groups of 8 mice each, each group was fed adaptively 7 days before the test, and had free feeding and drinking water during the period of time. The pad was replaced periodically and body weight was measured every three days. During the test period, the cervical vertebrae were sacrificed after feeding water for 24 hours after continuous gastric lavage for 30 days once daily, and the visceral index (thymus/body weight; spleen/body weight), cellular immune function (delayed type pathological response test-ear swelling degree), and NK cell activity (lactate dehydrogenase activity) were measured.
1. Influence of glehnia root health-care product on organ index of mice
The mice were weighed before death, and thymus and spleen were removed by planing and weighed, calculated according to the following formula:
thymus index = thymus weight (mg)/mouse weight (g)
Spleen index = spleen weight (mg)/mouse weight (g)
Results: the thymus and spleen can intuitively express the health condition of the organism by taking the thymus and spleen as immune organs of the organism, and as can be seen from the table 1, compared with a blank group, the thymus index has extremely obvious difference between a high-dose group and a medium-dose group (P is less than 0.01), and the low-dose group has obvious difference (P is less than 0.05); the difference between the high dose group and the medium dose group is extremely remarkable (P < 0.01) in spleen index, and the difference between the low dose group is remarkable (P < 0.05); the mice of the experimental group had higher body weights than the blank group, but were not statistically significant.
TABLE 1 influence of Glehniae radix health products on organ index of mice (A.+ -. Sigma)
Note that: p.ltoreq.0.05 is significant compared to the blank; p.ltoreq.0.01 is very significant
2. Influence of glehnia root health care product on cellular immunity
Delayed onset pathological response test-ear swelling degree. The abdomen of each mouse is dehaired by dehairing paste for about 4cm multiplied by 4cm in the 25 th day of stomach filling, 50 mu L of dinitrochlorobenzene solution is uniformly smeared on the dehairing position for sensitization, 10 mu L of dinitrochlorobenzene solution is uniformly smeared on two sides of the right ear of the mouse after 5 days, the left ear shell and the right ear shell of the mouse are killed after 24 hours, a disc with the diameter of 6mm is taken off by a puncher and weighed, and the ear swelling rate is calculated according to the following formula:
results: the ear swelling degree of the experimental group is lower than that of the blank group as shown in table 2, wherein compared with the blank group, the difference between the high-dose group and the medium-dose group is extremely remarkable (P is smaller than 0.01), the difference between the low-dose group is remarkable (P is smaller than 0.05), and the old product can effectively reduce the ear swelling degree of mice, and obviously improve the inhibition ratio of the swelling degree of the mice, so that the radix glehniae health product is proved to have remarkable improvement on the cellular immunity function of the mice.
TABLE 2 influence of Glehniae radix health products on cellular immune function (A.+ -. Sigma)
Note that: p.ltoreq.0.05 is significant compared to the blank; p.ltoreq.0.01 is very significant
3. Effect of glehnia root health product on NK cell activity
Immediately after blood is taken from eyeballs of mice, the blood is centrifuged at 4000r/min for 10min to obtain serum, and the serum is measured according to a measurement method of a Lactate Dehydrogenase (LDH) kit. Lactate dehydrogenase activity was calculated according to the following formula:
4. results: from table 3, it can be seen that the activity of the lactic dehydrogenase of mice in the experimental group is higher than that of the blank group, and compared with the blank group, the high-dose group, the medium-dose group and the low-dose group of the glehnia root health product have significant differences (P is less than 0.05), which indicates that the glehnia root health product can significantly improve the NK cell activity of mice.
TABLE 3 Effect of Glehniae radix health products on NK cell Activity (A.+ -. Sigma)
Note that: p.ltoreq.0.05 is significant compared to the blank; p.ltoreq.0.01 is very significant
While the fundamental and principal features of the invention and advantages of the invention have been shown and described, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to specific embodiments, and that the embodiments may be combined as appropriate, and that other embodiments may be understood by those skilled in the art.
Claims (5)
1. A health product for improving immunity by using glehnia root is characterized in that: the health care product is prepared from the following raw materials in parts by weight: 2-25 parts of rhizoma Panacis Japonici, 5-30 parts of radix Pseudostellariae, 10-35 parts of radix Glehniae, 10-15 parts of fructus Lycii, 15-20 parts of fructus Jujubae, 15-20 parts of longan, 10-15 parts of cortex Cinnamomi and 10-20 parts of Coicis semen.
2. The health product for improving immunity by using glehnia littoralis according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 10 parts of panax japonicus, 20 parts of radix pseudostellariae, 15 parts of radix glehniae, 10 parts of medlar, 15 parts of red dates, 18 parts of longan, 12 parts of cinnamon and 15 parts of pearl barley.
3. The health product for improving immunity by using glehnia littoralis according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 10 parts of panax japonicus, 25 parts of radix pseudostellariae, 35 parts of radix glehniae, 12 parts of medlar, 18 parts of red dates, 18 parts of longan, 12 parts of cinnamon and 15 parts of pearl barley.
4. A method for preparing a health product for enhancing immunity by using glehnia littoralis according to any one of claims 1 to 3, comprising the following steps:
(1) Mixing: uniformly mixing the rhizoma Panacis Japonici, radix Pseudostellariae, radix Glehniae, fructus Lycii, fructus Jujubae, arillus longan, cortex Cinnamomi and Coicis semen at a certain ratio to obtain mixed powder;
(2) Softening: mixing the mixed powder with alcohol to obtain softened mixed powder;
(3) Granulating: granulating the softened mixed powder through a granulator to obtain granular mixed powder;
(4) And (3) drying: drying the granular mixed powder by a dryer to obtain finished granular mixed powder;
(5) Mixing and tabletting: uniformly mixing the finished particle mixed powder and magnesium stearate powder to obtain a total mixture, and tabletting the total mixture to obtain tablet cores; and coating to obtain the finished product.
5. The method for preparing the health care product for improving immunity by using glehnia root as claimed in claim 4, wherein the method is characterized in that the glehnia root, the pseudostellaria root and the glehnia root are soaked in water for 2 hours before mixing, decocted for 1.5 hours each time, the water addition amount is 10 times and 8 times respectively, the decocted liquid is centrifuged at high speed for 3500-5000 rpm for half an hour, vacuum drying (the temperature is less than or equal to 70 ℃), and the paste is crushed and then sieved by a 80-mesh sieve.
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