CN116854562A - 柠檬醛选择性加氢合成橙花醇与香叶醇的方法 - Google Patents
柠檬醛选择性加氢合成橙花醇与香叶醇的方法 Download PDFInfo
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- CN116854562A CN116854562A CN202310625153.4A CN202310625153A CN116854562A CN 116854562 A CN116854562 A CN 116854562A CN 202310625153 A CN202310625153 A CN 202310625153A CN 116854562 A CN116854562 A CN 116854562A
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- Prior art keywords
- geraniol
- nerol
- citral
- synthesizing
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- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 title claims abstract description 144
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 title claims abstract description 58
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 229940043350 citral Drugs 0.000 title claims abstract description 55
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 title claims abstract description 37
- 239000005792 Geraniol Substances 0.000 title claims abstract description 37
- 229940113087 geraniol Drugs 0.000 title claims abstract description 37
- GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 title claims abstract description 35
- 238000000034 method Methods 0.000 title claims abstract description 31
- 230000002194 synthesizing effect Effects 0.000 title claims abstract description 19
- 238000006243 chemical reaction Methods 0.000 claims abstract description 61
- 239000001257 hydrogen Substances 0.000 claims abstract description 36
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 36
- 239000003054 catalyst Substances 0.000 claims abstract description 25
- 239000012295 chemical reaction liquid Substances 0.000 claims abstract description 13
- 239000002904 solvent Substances 0.000 claims abstract description 13
- 229910052723 transition metal Inorganic materials 0.000 claims abstract description 12
- 150000003624 transition metals Chemical class 0.000 claims abstract description 12
- 238000005984 hydrogenation reaction Methods 0.000 claims abstract description 11
- 230000002378 acidificating effect Effects 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 238000001816 cooling Methods 0.000 claims abstract description 3
- 238000001704 evaporation Methods 0.000 claims abstract description 3
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 26
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 239000013110 organic ligand Substances 0.000 claims description 11
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 150000002431 hydrogen Chemical class 0.000 claims description 9
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- BCJVBDBJSMFBRW-UHFFFAOYSA-N 4-diphenylphosphanylbutyl(diphenyl)phosphane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCCCP(C=1C=CC=CC=1)C1=CC=CC=C1 BCJVBDBJSMFBRW-UHFFFAOYSA-N 0.000 claims description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 6
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 6
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims description 6
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 claims description 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- MUALRAIOVNYAIW-UHFFFAOYSA-N binap Chemical group C1=CC=CC=C1P(C=1C(=C2C=CC=CC2=CC=1)C=1C2=CC=CC=C2C=CC=1P(C=1C=CC=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 MUALRAIOVNYAIW-UHFFFAOYSA-N 0.000 claims description 4
- 150000001879 copper Chemical class 0.000 claims description 4
- QTMDXZNDVAMKGV-UHFFFAOYSA-L copper(ii) bromide Chemical compound [Cu+2].[Br-].[Br-] QTMDXZNDVAMKGV-UHFFFAOYSA-L 0.000 claims description 4
- 150000002815 nickel Chemical class 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 4
- MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 claims description 4
- DEUJSGDXBNTQMY-UHFFFAOYSA-N 1,2,2-trifluoroethanol Chemical compound OC(F)C(F)F DEUJSGDXBNTQMY-UHFFFAOYSA-N 0.000 claims description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 3
- 229910021586 Nickel(II) chloride Inorganic materials 0.000 claims description 3
- MQRWBMAEBQOWAF-UHFFFAOYSA-N acetic acid;nickel Chemical compound [Ni].CC(O)=O.CC(O)=O MQRWBMAEBQOWAF-UHFFFAOYSA-N 0.000 claims description 3
- AMIQYYQOAAQNTI-UHFFFAOYSA-N copper triphenylphosphane dinitrate Chemical compound [Cu++].[O-][N+]([O-])=O.[O-][N+]([O-])=O.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1 AMIQYYQOAAQNTI-UHFFFAOYSA-N 0.000 claims description 3
- SBTSVTLGWRLWOD-UHFFFAOYSA-L copper(ii) triflate Chemical compound [Cu+2].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F SBTSVTLGWRLWOD-UHFFFAOYSA-L 0.000 claims description 3
- GPAYUJZHTULNBE-UHFFFAOYSA-N diphenylphosphine Chemical compound C=1C=CC=CC=1PC1=CC=CC=C1 GPAYUJZHTULNBE-UHFFFAOYSA-N 0.000 claims description 3
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 claims description 3
- 235000019253 formic acid Nutrition 0.000 claims description 3
- 229940078494 nickel acetate Drugs 0.000 claims description 3
- 229940078487 nickel acetate tetrahydrate Drugs 0.000 claims description 3
- QMMRZOWCJAIUJA-UHFFFAOYSA-L nickel dichloride Chemical compound Cl[Ni]Cl QMMRZOWCJAIUJA-UHFFFAOYSA-L 0.000 claims description 3
- BMGNSKKZFQMGDH-FDGPNNRMSA-L nickel(2+);(z)-4-oxopent-2-en-2-olate Chemical compound [Ni+2].C\C([O-])=C\C(C)=O.C\C([O-])=C\C(C)=O BMGNSKKZFQMGDH-FDGPNNRMSA-L 0.000 claims description 3
- OINIXPNQKAZCRL-UHFFFAOYSA-L nickel(2+);diacetate;tetrahydrate Chemical compound O.O.O.O.[Ni+2].CC([O-])=O.CC([O-])=O OINIXPNQKAZCRL-UHFFFAOYSA-L 0.000 claims description 3
- KVRSDIJOUNNFMZ-UHFFFAOYSA-L nickel(2+);trifluoromethanesulfonate Chemical compound [Ni+2].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F KVRSDIJOUNNFMZ-UHFFFAOYSA-L 0.000 claims description 3
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 claims description 3
- 235000019260 propionic acid Nutrition 0.000 claims description 3
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 3
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 claims description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims description 2
- QFMZQPDHXULLKC-UHFFFAOYSA-N 1,2-bis(diphenylphosphino)ethane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)C1=CC=CC=C1 QFMZQPDHXULLKC-UHFFFAOYSA-N 0.000 claims description 2
- 229910021591 Copper(I) chloride Inorganic materials 0.000 claims description 2
- 229910021590 Copper(II) bromide Inorganic materials 0.000 claims description 2
- 235000011054 acetic acid Nutrition 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 claims description 2
- 229910000024 caesium carbonate Inorganic materials 0.000 claims description 2
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 claims description 2
- XTVVROIMIGLXTD-UHFFFAOYSA-N copper(II) nitrate Chemical compound [Cu+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O XTVVROIMIGLXTD-UHFFFAOYSA-N 0.000 claims description 2
- QYJPSWYYEKYVEJ-FDGPNNRMSA-L copper;(z)-4-oxopent-2-en-2-olate Chemical compound [Cu+2].C\C([O-])=C\C(C)=O.C\C([O-])=C\C(C)=O QYJPSWYYEKYVEJ-FDGPNNRMSA-L 0.000 claims description 2
- 229940076286 cupric acetate Drugs 0.000 claims description 2
- 229940045803 cuprous chloride Drugs 0.000 claims description 2
- LZWQNOHZMQIFBX-UHFFFAOYSA-N lithium;2-methylpropan-2-olate Chemical compound [Li+].CC(C)(C)[O-] LZWQNOHZMQIFBX-UHFFFAOYSA-N 0.000 claims description 2
- UQPSGBZICXWIAG-UHFFFAOYSA-L nickel(2+);dibromide;trihydrate Chemical compound O.O.O.Br[Ni]Br UQPSGBZICXWIAG-UHFFFAOYSA-L 0.000 claims description 2
- 229910000008 nickel(II) carbonate Inorganic materials 0.000 claims description 2
- ZULUUIKRFGGGTL-UHFFFAOYSA-L nickel(ii) carbonate Chemical compound [Ni+2].[O-]C([O-])=O ZULUUIKRFGGGTL-UHFFFAOYSA-L 0.000 claims description 2
- KFBKRCXOTTUAFS-UHFFFAOYSA-N nickel;triphenylphosphane Chemical compound [Ni].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 KFBKRCXOTTUAFS-UHFFFAOYSA-N 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 abstract description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 20
- 239000000047 product Substances 0.000 description 16
- 239000003921 oil Substances 0.000 description 12
- 235000019198 oils Nutrition 0.000 description 12
- 239000007789 gas Substances 0.000 description 10
- 229910052757 nitrogen Inorganic materials 0.000 description 10
- RHQDFWAXVIIEBN-UHFFFAOYSA-N Trifluoroethanol Chemical compound OCC(F)(F)F RHQDFWAXVIIEBN-UHFFFAOYSA-N 0.000 description 4
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012621 metal-organic framework Substances 0.000 description 2
- 238000002161 passivation Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- ZENOXNGFMSCLLL-UHFFFAOYSA-N vanillyl alcohol Chemical compound COC1=CC(CO)=CC=C1O ZENOXNGFMSCLLL-UHFFFAOYSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- PRNCMAKCNVRZFX-UHFFFAOYSA-N 3,7-dimethyloctan-1-ol Chemical compound CC(C)CCCC(C)CCO PRNCMAKCNVRZFX-UHFFFAOYSA-N 0.000 description 1
- 241000208140 Acer Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000134874 Geraniales Species 0.000 description 1
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 235000000659 Rosa rugosa Nutrition 0.000 description 1
- 240000006066 Rosa rugosa Species 0.000 description 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- WTEVQBCEXWBHNA-YFHOEESVSA-N citral B Natural products CC(C)=CCC\C(C)=C/C=O WTEVQBCEXWBHNA-YFHOEESVSA-N 0.000 description 1
- 239000010632 citronella oil Substances 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- ZKXWKVVCCTZOLD-UHFFFAOYSA-N copper;4-hydroxypent-3-en-2-one Chemical compound [Cu].CC(O)=CC(C)=O.CC(O)=CC(C)=O ZKXWKVVCCTZOLD-UHFFFAOYSA-N 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000010648 geranium oil Substances 0.000 description 1
- 235000019717 geranium oil Nutrition 0.000 description 1
- 239000000852 hydrogen donor Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229930002839 ionone Natural products 0.000 description 1
- 150000002499 ionone derivatives Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000001289 litsea cubeba fruit oil Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- FBMAHDGTCDISLJ-UHFFFAOYSA-N neoavarol Natural products CC1CCC(C(CCC2)=C)(C)C2C1(C)CC1=CC(O)=CC=C1O FBMAHDGTCDISLJ-UHFFFAOYSA-N 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000012450 pharmaceutical intermediate Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 150000003303 ruthenium Chemical class 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 238000004729 solvothermal method Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- -1 zirconium 2-hydroxyphosphonoacetate Chemical compound 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group
- C07C29/141—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group with hydrogen or hydrogen-containing gases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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Abstract
本发明属于有机合成技术领域,公开了一种柠檬醛选择性加氢合成橙花醇与香叶醇的方法,包括以下步骤:将原料柠檬醛、过渡金属催化剂混合于溶剂,通入氢气,在碱性或者酸性的条件下,升温加压进行加氢反应,生成橙花醇和香叶醇,反应结束后,反应液冷却后蒸除溶剂,再去精馏得到橙花醇和香叶醇成品。本发明使用高效的过渡金属催化剂选择性的对柠檬醛碳氧双键加氢,以较高的转化率和选择性制备橙花醇和香叶醇,本发明操作简单,具有很高的工业化应用前景。
Description
技术领域
本发明属于有机合成技术领域,涉及一种橙花醇与香叶醇的合成方法,特别涉及一种柠檬醛选择性加氢合成橙花醇与香叶醇的方法。
背景技术
柠檬醛是一种具有多烯烃结构的α,β-不饱和醛,存在于枫茅油和山苍子油中,天然柠檬醛是一种由橙花醛和香叶醛组成的混合物,其选择性加氢产物有橙花醇和香叶醇。橙花醇和香叶醇互为顺反异构体,为无色至淡黄色油状液体,天然存在于橙花油、香叶油、香茅油、玫瑰草油、玫瑰油等中,具有柔和香甜的玫瑰香气,具有广泛的功能和应用价值。作为一种贵重的香料,广泛应用于食品、香皂和日用化妆品等香精的调配使用中。是重要的香料和医药中间体,用作制造香草醇、香草醛、紫罗兰酮和维生素A等的关键原料。也可入药,用于抗菌和驱虫,临床上对慢性支气管炎的治疗效果较为显著,具有起效快、副作用小等优点。
橙花醇和香叶醇是选择性对柠檬醛C=O双键加氢得到的产物,而柠檬醛中具有两个C=C双键和一个C=O双键,同时C=O双键的键能要大于C=C双键,因此柠檬醛选择性加氢合成橙花醇和香叶醇的方法的难点在于选择性和转化率难以达到很高的要求,反应过程中会产生香茅醇、二氢香茅醇等副产物,由于产物和副产物沸点较近,不易分离,对生产带来困难。
目前,柠檬醛选择性加氢合成橙花醇和香叶醇的方法主要集中在研究开发各种类型的催化剂,高选择性的对C=O双键进行加氢反应而不对C=C双键进行加氢反应。报道最多的是以是利用负载型催化剂进行加氢合成橙花醇和香叶醇。如CNl01747152报道了负载在氧化铁上的铂为催化剂,CN02155367.X报道了碳负载的掺杂铁的钌催化剂。
此外,CN110963888描述了金属钌盐等与有机配体经溶剂热法合成MOFs材料,并通过气相或液相沉积法引入钝化组分Si为催化剂,钝化组分Si消弱了外表面的催化活性,同时改变了金属骨架催化剂的孔径结构,增强了MOFs的空间择型能力,由于柠檬醛中端位的C= O双键位阻较小,使柠檬醛分子中的C = O双键优先吸附在金属活性中心上,从而达到提高柠檬醛加氢产物中橙花醇与香叶醇含量的目的,柠檬醛转化率可达99.5%,橙花醇和香叶醇总选择性98.9%以上。但是该方法催化剂制备复杂且用时较长,催化剂用量较大(柠檬醛和催化剂的摩尔量之比为100:1~5)。
CN111925275描述了一种通过溶剂法制备2-羟基膦酰基乙酸锆(Zr-HPAA)催化剂,用于选择性地催化氢化柠檬醛制备香叶醇。该反应为非均相催化反应体系,柠檬醛选择性加氢到香叶醇不使用氢气,以异丙醇为氢供体,需使用大量的溶剂。该反应对温度要求较高,对转化率和选择性有重要影响。同时该催化剂使用溶剂法制备,过程较为复杂、耗时,催化剂用量较大。
发明内容
针对现有技术的不足,本发明的目的在于提供一种柠檬醛选择性加氢合成橙花醇与香叶醇的方法,本发明使用高效的过渡金属催化剂选择性的对柠檬醛碳氧双键加氢,以较高的转化率和选择性制备橙花醇和香叶醇,本发明操作简单,具有很高的工业化应用前景。
本发明是通过以下技术方案实现的:
柠檬醛选择性加氢合成橙花醇与香叶醇的方法,包括以下步骤:
将原料柠檬醛、过渡金属催化剂混合于溶剂,通入氢气,在碱性或者酸性的条件下,升温加压进行加氢反应,生成橙花醇和香叶醇,反应结束后,反应液冷却后蒸除溶剂,再去精馏得到橙花醇和香叶醇成品;所述过渡金属催化剂由金属镍盐或铜盐与有机配体组成。
化学反应方程式如下所示:
本发明的进一步改进方案为:
所述金属镍盐为溴化镍、氯化镍、碳酸镍、四水乙酸镍、无水乙酸镍、乙酰丙酮镍、四(三苯基膦)镍或三氟甲磺酸镍中的一种或两种以上混合。
进一步的,所述铜盐为硝酸铜、双(三苯基膦)硝酸铜、氯化亚铜、氯化铜、溴化铜、三氟甲磺酸铜、醋酸铜或乙酰丙酮铜中的一种或两种以上混合。
进一步的,所述有机配体为三苯基膦、1,2-双(二苯基膦)乙烷、1,4-双(二苯基膦)丁烷、1,1'-双(二苯基膦)二茂铁、(±)-2,2'-双-(二苯膦基)-1,1'-联萘或 rac-QuinoxP中的一种或两种以上混合。
进一步的,酸性条件为在反应体系中加入甲酸、乙酸或丙酸中的一种或两种以上混合。
进一步的,碱性条件为在反应体系中加入氢氧化钾、氢氧化钠、氢氧化锂、叔丁醇钾、叔丁醇钠、叔丁醇锂、碳酸钾、碳酸钠、碳酸铯或甲醇钠中的一种或两种以上混合。
进一步的,所述溶剂为甲醇、乙醇、正丙醇、异丙醇、2,2,2-三氟乙醇、六氟异丙醇、甲苯、四氢呋喃或1,2-二氯乙烷中的一种或两种以上混合。
进一步的,所述过渡金属催化剂中过渡金属与有机配体的摩尔比为1~5﹕1;柠檬醛与有机配体的摩尔比为5000﹕1~5。
进一步的,当反应在酸性条件下进行时,溶剂与酸的体积之比为2~100﹕1;当反应在碱性条件下进行时,有机配体与碱的摩尔比为1﹕2~25。
进一步的,所述加氢反应的温度为25~80℃,时间为12~24h,氢气压力为20-60MPa。
与现有技术相比,本发明的有益效果为:
过渡金属镍催化剂或铜催化剂为丰产金属催化剂,原料易得,可以通过原位生成或简单处理得到预制备催化剂,能在较小催化剂用量的条件下获得较好的转化率,同时橙花醇和香叶醇的选择性较高。具备操作简单,对设备要求低,产品质量高等优点,具有很高的工业化应用前景。
实施方式
下面结合具体实施例对本发明进行详细的介绍。
实施例1
在氮气手套箱中,将柠檬醛(1 mmol),乙酸镍四水合物(0.5 mol%),rac-QuinoxP(0.5 mol%),三氟乙醇/乙酸(2 mL/0.5 mL)加入到10 mL反应瓶中,将反应瓶放入高压反应釜中。将高压釜移出手套箱后,用氢气(10 bar)进行加压排气三次置换气体,然后用氢气加压至20 bar,将高压釜置于40 ℃油浴中反应12 h。反应结束后,降温,缓慢释放氢气,反应液用GC检测,柠檬醛的转化率为98%,产物的选择性为97%。
实施例2
在氮气手套箱中,将柠檬醛(1 mmol),三氟甲磺酸镍(0.5 mol%),三苯基膦(0.2mol%),三氟乙醇/乙酸(2.3 mL/0.2 mL)加入到10 mL反应瓶中,将反应瓶放入高压反应釜中。将高压釜移出手套箱后,用氢气(10 bar)进行加压排气三次置换气体,然后用氢气加压至40 bar,将高压釜置于40 ℃油浴中反应18 h。反应结束后,降温,缓慢释放氢气,反应液用GC检测,柠檬醛的转化率为91%,产物的选择性为94%。
实施例3
在氮气手套箱中,将柠檬醛(1 mmol),氯化镍(0.1 mol%),1,4-双(二苯基膦)丁烷(0.1 mol%),2,2,2-三氟乙醇/甲酸(1.6 mL/0.8 mL)加入到10 mL反应瓶中,将反应瓶放入高压反应釜中。将高压釜移出手套箱后,用氢气(10 bar)进行加压排气三次置换气体,然后用氢气加压至50 bar,将高压釜置于60 ℃油浴中反应20 h。反应结束后,降温,缓慢释放氢气,反应液用GC检测,柠檬醛的转化率为95%,产物的选择性为98%。
实施例4
在氮气手套箱中,将柠檬醛(5 mmol),乙酸镍(0.1 mol%),1,1'-双(二苯基膦)二茂铁(0.1 mol%),三氟乙醇/乙酸(10 mL/0.1 mL)加入到50 mL反应瓶中,将反应瓶放入高压反应釜中。将高压釜移出手套箱后,用氢气(10 bar)进行加压排气三次置换气体,然后用氢气加压至40 bar,将高压釜置于50 ℃油浴中反应20 h。反应结束后,降温,缓慢释放氢气,反应液用GC检测,柠檬醛的转化率为90%,产物的选择性为95%。
实施例5
在氮气手套箱中,将柠檬醛(5 mmol),乙酰丙酮镍(0.1 mol%),(±)-2,2'-双-(二苯膦基)-1,1'-联萘(0.05 mol%),三氟乙醇/丙酸(10 mL/2 mL)加入到50 mL反应瓶中,将反应瓶放入高压反应釜中。将高压釜移出手套箱后,用氢气(10 bar)进行加压排气三次置换气体,然后用氢气加压至60 bar,将高压釜置于80 ℃油浴中反应24 h。反应结束后,降温,缓慢释放氢气,反应液用GC检测,柠檬醛的转化率为94%,产物的选择性为97%。
实施例6
在氮气手套箱中,将柠檬醛(10 mmol),醋酸铜(0.1 mol%),1,4-双(二苯基膦)丁烷(0.1 mol%),氢氧化钠(1 mol%),乙醇(15 mL)加入到50 mL反应瓶中,将反应瓶放入高压反应釜中。将高压釜移出手套箱后,用氢气(10 bar)进行加压排气三次置换气体,然后用氢气加压至20 bar,将高压釜置于50 ℃油浴中反应16 h。反应结束后,降温,缓慢释放氢气,反应液用GC检测,柠檬醛的转化率为97%,产物的选择性为93%。
实施例7
在氮气手套箱中,将柠檬醛(10 mmol),三氟甲磺酸铜(0.1 mol%),1,4-双(二苯基膦)丁烷(0.1 mol%),叔丁醇钾(1 mol%),甲醇(15 mL)加入到50 mL反应瓶中,将反应瓶放入高压反应釜中。将高压釜移出手套箱后,用氢气(10 bar)进行加压排气三次置换气体,然后用氢气加压至20 bar,将高压釜置于50 ℃油浴中反应18 h。反应结束后,降温,缓慢释放氢气,反应液用GC检测,柠檬醛的转化率为95%,产物的选择性为94%。
实施例8
在氮气手套箱中,将柠檬醛(10 mol),氯化铜(0.1 mol%),1,4-双(二苯基膦)丁烷(0.1 mol%),甲醇钠(0.5 mol%),乙醇(15 mL)加入到50 mL反应瓶中,将反应瓶放入高压反应釜中。将高压釜移出手套箱后,用氢气(10 bar)进行加压排气三次置换气体,然后用氢气加压至50 bar,将高压釜置于50 ℃油浴中反应24 h。反应结束后,降温,缓慢释放氢气,反应液用GC检测,柠檬醛的转化率为97%,产物的选择性为95%。
实施例9
在氮气手套箱中,将柠檬醛(10 mol),乙酰丙酮铜(0.2 mol%),(±)-2,2'-双-(二苯膦基)-1,1'-联萘(0.1 mol%),甲醇钠(2 mol%),四氢呋喃(20 mL)加入到50 mL反应瓶中,将反应瓶放入高压反应釜中。将高压釜移出手套箱后,用氢气(10 bar)进行加压排气三次置换气体,然后用氢气加压至50 bar,将高压釜置于40 ℃油浴中反应18 h。反应结束后,降温,缓慢释放氢气,反应液用GC检测,柠檬醛的转化率为95%,产物的选择性为92%。
实施例10
在氮气手套箱中,将柠檬醛(10 mol),双(三苯基膦)硝酸铜(0.1 mol%),1,4-双(二苯基膦)丁烷(0.02 mol%),氢氧化钠(0.5 mol%),乙醇(15 mL)加入到50 mL反应瓶中,将反应瓶放入高压反应釜中。将高压釜移出手套箱后,用氢气(10 bar)进行加压排气三次置换气体,然后用氢气加压至50 bar,将高压釜置于60 ℃油浴中反应24 h。反应结束后,降温,缓慢释放氢气,反应液用GC检测,柠檬醛的转化率为96%,产物的选择性为95%。
上述实施方式只为说明本发明的技术构思及特点,其目的在于让熟悉此项技术的人能够了解本发明的内容并据以实施,并不能以此限制本发明的保护范围。凡根据本发明精神实质所做的等效变换或修饰,都应涵盖在本发明的保护范围之内。
Claims (10)
1.柠檬醛选择性加氢合成橙花醇与香叶醇的方法,其特征在于,包括以下步骤:将原料柠檬醛、过渡金属催化剂混合于溶剂,通入氢气,在碱性或者酸性的条件下,升温加压进行加氢反应,生成橙花醇和香叶醇,反应结束后,反应液冷却后蒸除溶剂,再去精馏得到橙花醇和香叶醇成品;所述过渡金属催化剂由金属镍盐或铜盐与有机配体组成。
2.根据权利要求1所述的柠檬醛选择性加氢合成橙花醇与香叶醇的方法,其特征在于:所述金属镍盐为溴化镍、氯化镍、碳酸镍、四水乙酸镍、无水乙酸镍、乙酰丙酮镍、四(三苯基膦)镍或三氟甲磺酸镍中的一种或两种以上混合。
3.根据权利要求1所述的柠檬醛选择性加氢合成橙花醇与香叶醇的方法,其特征在于:所述铜盐为硝酸铜、双(三苯基膦)硝酸铜、氯化亚铜、氯化铜、溴化铜、三氟甲磺酸铜、醋酸铜或乙酰丙酮铜中的一种或两种以上混合。
4.根据权利要求1所述的柠檬醛选择性加氢合成橙花醇与香叶醇的方法,其特征在于:所述有机配体为三苯基膦、1,2-双(二苯基膦)乙烷、1,4-双(二苯基膦)丁烷、1,1'-双(二苯基膦)二茂铁、(±)-2,2'-双-(二苯膦基)-1,1'-联萘或 rac-QuinoxP中的一种或两种以上混合。
5.根据权利要求1所述的柠檬醛选择性加氢合成橙花醇与香叶醇的方法,其特征在于:酸性条件为在反应体系中加入甲酸、乙酸或丙酸中的一种或两种以上混合。
6.根据权利要求1所述的柠檬醛选择性加氢合成橙花醇与香叶醇的方法,其特征在于:碱性条件为在反应体系中加入氢氧化钾、氢氧化钠、氢氧化锂、叔丁醇钾、叔丁醇钠、叔丁醇锂、碳酸钾、碳酸钠、碳酸铯或甲醇钠中的一种或两种以上混合。
7.根据权利要求1所述的柠檬醛选择性加氢合成橙花醇与香叶醇的方法,其特征在于:所述溶剂为甲醇、乙醇、正丙醇、异丙醇、2,2,2-三氟乙醇、六氟异丙醇、甲苯、四氢呋喃或1,2-二氯乙烷中的一种或两种以上混合。
8.根据权利要求1所述的柠檬醛选择性加氢合成橙花醇与香叶醇的方法,其特征在于:所述过渡金属催化剂中过渡金属与有机配体的摩尔比为1~5﹕1;柠檬醛与有机配体的摩尔比为5000﹕1~5。
9.根据权利要求1所述的柠檬醛选择性加氢合成橙花醇与香叶醇的方法,其特征在于:当反应在酸性条件下进行时,溶剂与酸的体积之比为2~100﹕1;当反应在碱性条件下进行时,有机配体与碱的摩尔比为1﹕2~25。
10.根据权利要求1所述的柠檬醛选择性加氢合成橙花醇与香叶醇的方法,其特征在于:所述加氢反应的温度为25~80℃,时间为12~24h,氢气压力为20-60MPa。
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