CN116832114A - Traditional Chinese medicine composition for improving quality of male ducks semen and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for improving quality of male ducks semen and preparation method and application thereof Download PDFInfo
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- CN116832114A CN116832114A CN202310984054.5A CN202310984054A CN116832114A CN 116832114 A CN116832114 A CN 116832114A CN 202310984054 A CN202310984054 A CN 202310984054A CN 116832114 A CN116832114 A CN 116832114A
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Abstract
The invention discloses a traditional Chinese medicine composition for improving the semen quality of a male duck, and a preparation method and application thereof, wherein the active ingredients of the traditional Chinese medicine composition are prepared from the following components: angelica sinensis, dangshen, aconite, cinnamon, prepared rehmannia root, semen cuscutae, shizandra berry, dwarf lilyturf tuber, largehead atractylodes rhizome and liquorice. The composition provided by the invention has the effects of improving the sexual desire of the male ducks, promoting the secretion of the male ducks semen, improving the quality of the male ducks semen and enhancing the reproductive performance, can obviously improve the quality of the male ducks semen in the production and breeding work of the breeding ducks, improves the use value of the breeding ducks, and improves the breeding benefit and the breeding efficiency.
Description
Technical Field
The invention relates to the technical field of animal medicines, in particular to a traditional Chinese medicine composition for improving the semen quality of a male duck and a preparation method and application thereof.
Background
Under the dual pressures of environment protection and efficient breeding, the water poultry cage breeding mode is developing towards modernization, scale and intensification, the inherent life habit of the water poultry cage breeding is changed, the production performance is not affected to a certain extent, particularly the semen quality of the breeding ducks is obviously reduced, the reproductive performance is seriously affected, in addition, the artificial insemination technology is one of key technologies for restricting the breeding ducks cage breeding, wherein the semen quality of the breeding ducks is directly related to the reproductive performance of female ducks and the production performance of offspring thereof, and therefore, the improvement of the semen quality of the breeding ducks is a very important work.
At present, researches on the male ducks mainly focus on the artificial insemination technologies such as the selection and washing, training, semen collection, semen quality inspection and semen delivery of the male ducks, basic nutrition requirements, disease prevention and control, production performance and the like, the method for improving the semen quality of the male ducks mainly comprises single addition of vitamins, amino acids, nutrition level changes and the like, and an economic and effective method for improving the reproductive performance of the male ducks is established by adding Chinese herbal medicine compound functional additives, so that the method belongs to the leading-edge field of researches on additive addition programs for improving the health of breeding birds, and experimental researches on the aspects are of great value and significance. The traditional Chinese medicine has the advantages of abundant resources, low toxicity, low medicine residue and the like, china has huge breeding market and abundant traditional Chinese medicine resources, has long history of traditional Chinese medicine research, and along with continuous progress of scientific technology, the traditional Chinese medicine feed additive has great development prospect. In order to fully exert the genetic advantages of the individuals with the superior ducks and accelerate the fine variety breeding and hybridization utilization, the invention provides a traditional Chinese medicine composition for improving the semen quality of the ducks and a preparation method and application thereof.
Disclosure of Invention
The invention aims to: the invention aims to solve the technical problem of providing a traditional Chinese medicine composition for improving the semen quality of a drake, aiming at the defects of the prior art.
The invention also solves the technical problem of providing a preparation comprising the traditional Chinese medicine composition.
The invention also solves the technical problem of providing a preparation method of the traditional Chinese medicine composition.
The invention also solves the technical problem of providing the application of the traditional Chinese medicine composition and the preparation.
The invention is characterized in that: the invention adopts the traditional Chinese medicine composition for warming yang and warming kidney, tonifying kidney and securing essence, and supplementing qi and nourishing blood, thereby solving the problem of hyposexuality caused by frequent semen collection of the male ducks, improving the sexual desire of the male ducks, promoting semen secretion, improving semen quality and improving the reproductive performance of the male ducks.
In order to solve the first technical problem, the invention discloses a traditional Chinese medicine composition for improving the sexual desire of a male duck, promoting the secretion of the semen of the male duck, improving the semen quality of the male duck or improving the reproductive performance of the male duck, and the active ingredients of the traditional Chinese medicine composition are prepared from the following components: angelica sinensis, dangshen, aconite, cinnamon, prepared rehmannia root, semen cuscutae, shizandra berry, dwarf lilyturf tuber, largehead atractylodes rhizome and liquorice.
The prepared aconite root, cinnamon, and the Chinese cinnamon are used as monarch drugs for warming yang and kidney and tonifying the deficiency of the vital gate; the Chinese angelica is used for nourishing blood, and the dangshen and the bighead atractylodes rhizome are used as ministerial drugs; radix Ophiopogonis has effects of nourishing yin, promoting fluid production, and relieving dryness of cortex Cinnamomi, radix rehmanniae Preparata has effects of invigorating kidney, nourishing yin, glycyrrhrizae radix has effects of invigorating spleen, replenishing qi, and harmonizing the above drugs, and is used as adjuvant drug; the Chinese dodder is pungent and sweet in flavor, flat in nature, and the Chinese magnoliavine fruit is sour and sweet in flavor and warm in nature, and is a kidney meridian-guiding drug. The combination of the medicines can effectively solve the problem that artificial semen collection reflex is insensitive caused by the decreased sexual desire of the duckling due to frequent semen collection, and simultaneously is beneficial to improving the sexual desire of the duckling, promoting semen formation and secretion, improving semen quality and improving the reproductive performance of the duckling.
In some embodiments, the active ingredients of the traditional Chinese medicine composition comprise, by weight, 20-30 parts of angelica sinensis, 40-60 parts of radix codonopsis pilosulae, 20-30 parts of aconite, 20-30 parts of cinnamon, 20-30 parts of prepared rehmannia root, 20-30 parts of semen cuscutae, 20-30 parts of schisandra chinensis, 20-30 parts of radix ophiopogonis, 20-30 parts of bighead atractylodes rhizome and 10-15 parts of liquorice; in some embodiments, the active ingredients of the traditional Chinese medicine composition comprise, by weight, 20 parts of angelica sinensis, 40 parts of codonopsis pilosula, 20 parts of aconite, 20 parts of cinnamon, 20 parts of prepared rehmannia root, 20 parts of semen cuscutae, 20 parts of schisandra chinensis, 20 parts of radix ophiopogonis, 20 parts of bighead atractylodes rhizome and 10 parts of liquorice; in some embodiments, the active ingredients of the traditional Chinese medicine composition comprise 20g of angelica sinensis, 40g of codonopsis pilosula, 20g of aconite, 20g of cinnamon, 20g of prepared rehmannia root, 20g of semen cuscutae, 20g of shizandra berry, 20g of dwarf lilyturf tuber, 20g of bighead atractylodes rhizome and 10g of liquorice.
In order to solve the second technical problem, the invention discloses a traditional Chinese medicine composition preparation, which comprises the traditional Chinese medicine composition in the first technical problem.
In order to solve the third technical problem, the invention discloses a preparation method of the traditional Chinese medicine composition, as shown in fig. 1, comprising the following steps:
s1: weighing the components according to the formula, and crushing;
s2: soaking cortex Cinnamomi powder, distilling, and collecting distillate;
s3: dissolving radix Aconiti lateralis powder with hydrochloric acid, filtering, extracting the filtrate with organic solvent, collecting acid water layer, adjusting pH of acid water layer to 9-10, extracting with organic solvent, and collecting alkali water layer;
s4: soaking the powder of other components except cortex Cinnamomi and radix Aconiti lateralis in acidic alcohol solution, reflux extracting, and filtering to obtain filtrate and residue; recovering ethanol from the obtained filtrate, and regulating pH to 6.5-7.5; decocting the residue with water, and filtering to obtain filtrate;
s5: mixing the distillate obtained in step S2, the alkali water layer obtained in step S3, the filtrate obtained in step S4 after the pH adjustment, and the filtrate obtained after decoction of the residues, adjusting the pH to 6.5-7.5, concentrating, adsorbing the obtained concentrate with silicon dioxide, and drying to obtain the final product.
In step S1, the above-mentioned pulverization is carried out to obtain coarse powder of about 2 mm.
In step S2, in some embodiments, after the cinnamon is soaked wet, the cinnamon is distilled with direct fire heating, distilled 2 times, and the distillate is collected and combined.
In step S3, the organic solvent comprises CHCl 3 Preferably, the pH is adjusted by ammonia.
In step S4, the acidic alcohol solution is a mixed solution of hydrochloric acid and ethanol; preferably, the concentration of hydrochloric acid in the acidic alcohol solution is 0.01-0.08mol/L, preferably 0.05mol/L; the mass concentration of the ethanol in the acidic alcohol solution is 40% -60%, preferably 50%; preferably, the acidic alcohol solution is a mixed solution obtained by mixing 0.1mol/L hydrochloric acid and 95% ethanol according to a volume ratio of 1:1.
In step S4, the mass ratio of the solvent to the raw materials is (4-8): 1, preferably 6:1.
In the step S4, the reflux extraction time is 1-3h, preferably 2h; the temperature of the reflux extraction was 80 ℃.
In the step S4, other water-soluble active ingredients in the medicine residues can be completely extracted by decoction, so that the full efficacy of the medicine materials is effectively exerted.
Wherein the temperature of the decoction is 100 ℃; the number of times of the decoction is 1-3 times, preferably 2 times.
Wherein the decoction is water decoction, and the mass ratio of water to raw materials is (4-8): 1, preferably 6:1.
Wherein the time of the decoction is 1-3h, preferably 2h, more preferably 2h for the first time and 1.5h for the second time.
In step S5, the concentration is carried out to a density of 1.05-1.08g/cm 3 。
In the step S2, the concentration is performed by adopting a three-effect concentrator, so that the concentration time can be effectively shortened, and the loss of active ingredients can be reduced.
Wherein, each effect vacuum degree and evaporating temperature in the triple effect concentrator are: the first effect is-0.04 to-0.07 MPa,85 ℃; two-effect-0.06-0.08 MPa,75 ℃, three-effect-0.07-0.10 MPa,65 ℃.
In the step S5, the drying is carried out by adopting a granular silicon dioxide adsorption and blade screw drying method. The product has good fluidity, the volume weight is close to that of corn flour and soybean meal which are feed raw materials, and the uniformity of the addition of the corn flour and the soybean meal to the feed is good. The blade screw drying method has large heating area, short drying time and low energy consumption.
Wherein the mass ratio of the concentrated solution to the silicon dioxide is 1 (0.5-4.0), and is preferably 1:2.
In order to solve the fourth technical problem, the invention discloses application of the traditional Chinese medicine composition or the traditional Chinese medicine composition preparation in preparation of a product for improving the sexual desire of a drake, promoting the secretion of the sperm of the drake, improving the sperm quality of the drake or improving the reproductive performance of the drake.
Wherein the products include, but are not limited to, veterinary drugs, feed additives.
The beneficial effects are that: compared with the prior art, the invention has the following advantages:
(1) In the preparation process, the alkaloid components in the aconite are extracted by adopting stepwise extraction and adopting dilute hydrochloric acid ethanol solution, and other effective components are extracted by water, so that the extraction yield of the effective components is improved; the silica adsorption drying process is adopted, so that the drying time is shortened, the drying temperature is reduced, and the product flowability is increased.
(2) The composition provided by the invention has the effects of warming yang and warming kidney, tonifying kidney and securing essence, and tonifying qi and nourishing blood, can obviously improve the sexual desire of the male ducks, promote the semen secretion of the male ducks, improve the semen quality of the male ducks, enhance the reproductive performance, promote the seed value of the male ducks, fully exert the genetic advantages of the excellent male ducks, improve the breeding benefit and the breeding efficiency, and has obvious economic benefit and social benefit.
(3) The composition provided by the invention is a green and safe novel feed additive prepared from pure traditional Chinese medicines, and has the characteristics of safety, no side effect, quick response, no residue, obvious effect and the like.
Drawings
The foregoing and/or other advantages of the invention will become more apparent from the following detailed description of the invention when taken in conjunction with the accompanying drawings and detailed description.
Fig. 1 is a flow chart of a preparation process of the traditional Chinese medicine composition in the embodiment 1.
Fig. 2 is a comparison of sexual desire states before and after administration of the male ducks of example 4.
Detailed Description
The experimental methods described in the following examples are all conventional methods unless otherwise specified; the reagents and materials, unless otherwise specified, are commercially available.
Example 1
The formula of the components comprises: according to the weight portions, 20g of angelica, 40g of dangshen, 20g of aconite, 20g of cinnamon, 20g of prepared rehmannia root, 20g of semen cuscutae, 20g of shizandra berry, 20g of dwarf lilyturf tuber, 20g of bighead atractylodes rhizome and 10g of liquorice are respectively weighed, screened and cleaned.
The preparation process comprises the following steps:
(1) Weighing the raw materials according to the parts by weight; pulverizing the above materials into coarse powder of about 2 mm;
(2) Soaking cortex Cinnamomi powder in water at a mass ratio of 1:6 for 2 hr, extracting by steam distillation for 8 hr, and collecting distillate;
(3) Dissolving radix Aconiti lateralis powder in hydrochloric acid of 0.1mol/L at a mass ratio of 1:5, and filtering. The obtained filtrate was treated with the same volume of CHCl 3 Extracting, collecting acid water layer, adjusting pH to 10 with ammonia water, and adding CHCl with the same volume 3 Extracting, and collecting an alkali water layer for later use;
(4) Adding 0.05mol/L dilute hydrochloric acid 50% ethanol solution into the powder of other components, soaking for 60 minutes, carrying out reflux extraction at 77-79 ℃ for 2 hours, wherein the mass ratio of the solvent to the raw materials is 6:1, filtering to obtain filtrate and dregs, extracting the filtrate to recover ethanol, decocting the obtained dregs in water, keeping micro-boiling for 2 hours, filtering, combining the filtrates, and regulating the pH value to 7.0 by using sodium hydroxide;
(5) Combining the distillate of step (2) and the alkali water layer of step (3), regulating pH of the three filtrates of step (4) to 7.0 with hydrochloric acid, concentrating to density of 1.05-1.08g/cm with a triple effect concentrator 3 The method comprises the steps of carrying out a first treatment on the surface of the The vacuum degree and the evaporating temperature of each effect in the three-effect concentrator are as follows: the first effect is-0.04 to-0.07 MPa,85 ℃; two-effect-0.06-0.08 MPa,75 ℃, three-effect-0.07-0.10 MPa,65 ℃;
(6) Adding silicon dioxide into the concentrated solution, mixing, drying at 60 ℃, and adding the silicon dioxide into the concentrated solution in a mass ratio of 1:2;
(7) And sieving the dried intermediate to obtain a finished product.
Example 2
The formula of the components comprises: according to the weight portions, 25g of angelica, 50g of dangshen, 25g of aconite, 25g of cinnamon, 25g of prepared rehmannia root, 25g of semen cuscutae, 25g of shizandra berry, 25g of dwarf lilyturf tuber, 25g of bighead atractylodes rhizome and 13g of liquorice are respectively weighed, screened and cleaned.
The preparation process is the same as in example 1.
Example 3
The formula of the components comprises: according to the weight portions, 30g of angelica, 60g of dangshen, 30g of aconite, 30g of cinnamon, 30g of prepared rehmannia root, 30g of semen cuscutae, 30g of shizandra berry, 30g of dwarf lilyturf tuber, 30g of bighead atractylodes rhizome and 15g of liquorice are respectively weighed, screened and cleaned.
The preparation process is the same as in example 1.
Example 4: clinical verification
1. Test drug example 1 the water-soluble Chinese herbal compound extracted.
2. The test animals are provided by a certain duck farm in Nanjing, and the breeding mode is single cage breeding. 120 breeding ducks with healthy age and close weight are selected at 210 days.
3. The test group test adopts an animal sample self-control method, the male ducks are a control group (a non-administration stage) before administration, and an experimental group (an administration stage and a stopping stage) after administration. The grouping is shown in Table 1.
Table 1 test group
4. Test method
The male ducks on the 1 st day of the test drink water freely, no medicine is added, and the administration is carried out by drinking water according to requirements for 14 consecutive days from the 2 nd day, and then the administration is stopped and the free drinking water is carried out for 3 days. Semen and venous blood of the test ducks are manually collected on days 1, 15 and 18 in the test period, and relevant indexes of each group of test ducks are measured. The measurement index is shown in Table 2.
Table 2 measurement index
5. Test results
TABLE 3 influence of Chinese medicinal composition on the semen quality of male ducks
Note that: the same column indicates that the difference is significant (P < 0.05), the same letter indicates that the difference is not significant (P > 0.05), and the same follows.
Table 4 Effect of the Chinese medicinal composition on serum testosterone, luteinizing hormone and follicle stimulating hormone of the male Duck
The test results showed that the traditional Chinese medicine composition of example 1 can improve the libido (figure 2) and semen quality of the male ducks to some extent in the administration stage and a period of time after stopping administration compared with the control group. As can be seen from table 3, the semen of each group of the duckling is slightly alkaline, the pH value of the duckling semen in the administration stage and the dosing-stopping stage is slightly higher than that in the non-administration stage, but the difference is not obvious, if the pH value is lower, the motility of sperms can be influenced, and the traditional Chinese medicine composition has no adverse effect on the pH value of the semen; the traditional Chinese medicine composition in the embodiment 1 can obviously increase the semen quantity of the drake, and compared with the drug administration stage without drug administration, the average semen quantity of the drake in the drug administration stage and the drug withdrawal stage is increased by 0.551mL and 0.494mL; compared with the non-administration period, the sperm motility and the activation rate of the male ducks can be respectively increased by 20.88 percent and 25.02 percent, and the effect is still obvious in the stopping period; compared with the non-administration phase, the sperm density of the male ducks in the administration phase and the stopping phase is obviously improved, and the sperm density is respectively increased by 16.27 hundred million/mL and 15.80 hundred million/mL; the sperm malformation rate in the administration stage and the stopping stage is obviously reduced by 14.47 percent and 14.41 percent respectively, and the malformation rate in the stopping stage is still kept low.
The reproductive hormones in hypothalamus-pituitary gland-gonadal axis are closely related to the regulation of the reproductive function of the male ducks, testosterone (T), luteinizing Hormone (LH), follicle Stimulating Hormone (FSH) and the like are directly involved in spermatogenesis and maintenance, and as shown in table 4, the serum testosterone, luteinizing hormone and follicle stimulating hormone content of the male ducks are significantly increased in the administration phase compared with the non-administration phase, and the higher hormone level is still significantly maintained in the withdrawal phase, thereby promoting the normal sufficient production of sperm of the male ducks and affecting sperm quality.
The results show that: the invention discloses a traditional Chinese medicine composition for improving the semen quality of a male duck, which has the advantages of quick effect and obviously improved semen quality after the male duck is used, thereby playing a role in improving the reproductive performance of the male duck. Because the product is a pure traditional Chinese medicine, the use is safe and reliable, and the product can be widely applied to livestock and poultry cultivation.
The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (10)
1. The traditional Chinese medicine composition is characterized in that the active ingredients of the traditional Chinese medicine composition are prepared from the following components: angelica sinensis, dangshen, aconite, cinnamon, prepared rehmannia root, semen cuscutae, shizandra berry, dwarf lilyturf tuber, largehead atractylodes rhizome and liquorice.
2. The traditional Chinese medicine composition according to claim 1, wherein the weight parts of the components are 20-30 parts of angelica sinensis, 40-60 parts of radix codonopsis pilosulae, 20-30 parts of aconite, 20-30 parts of cinnamon, 20-30 parts of prepared rehmannia root, 20-30 parts of semen cuscutae, 20-30 parts of schisandra chinensis, 20-30 parts of dwarf lilyturf tuber, 20-30 parts of bighead atractylodes rhizome and 10-15 parts of liquorice.
3. The traditional Chinese medicine composition according to claim 1, wherein the weight parts of the components are 20 parts of angelica sinensis, 40 parts of codonopsis pilosula, 20 parts of aconite, 20 parts of cinnamon, 20 parts of prepared rehmannia root, 20 parts of semen cuscutae, 20 parts of schisandra chinensis, 20 parts of dwarf lilyturf tuber, 20 parts of bighead atractylodes rhizome and 10 parts of liquorice.
4. The traditional Chinese medicine composition according to claim 1, wherein the mass of each component is 20g of angelica sinensis, 40g of codonopsis pilosula, 20g of aconite, 20g of cinnamon, 20g of prepared rehmannia root, 20g of semen cuscutae, 20g of shizandra berry, 20g of dwarf lilyturf tuber, 20g of bighead atractylodes rhizome and 10g of liquorice.
5. A Chinese medicinal composition preparation, comprising the Chinese medicinal composition according to any one of claims 1 to 4.
6. The method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 4, comprising the following steps:
s1: weighing the components according to the formula, and crushing;
s2: soaking cortex Cinnamomi powder, distilling, and collecting distillate;
s3: dissolving radix Aconiti lateralis powder with hydrochloric acid, filtering, extracting the filtrate with organic solvent, collecting acid water layer, adjusting pH of acid water layer to 9-10, extracting with organic solvent, and collecting alkali water layer;
s4: soaking the powder of other components except cortex Cinnamomi and radix Aconiti lateralis in acidic alcohol solution, reflux extracting, and filtering to obtain filtrate and residue; recovering ethanol from the obtained filtrate, and regulating pH to 6.5-7.5; decocting the residue with water, and filtering to obtain filtrate;
s5: mixing the distillate obtained in step S2, the alkali water layer obtained in step S3, the filtrate obtained in step S4 after the pH adjustment, and the filtrate obtained after decoction of the residues, adjusting the pH to 6.5-7.5, concentrating, adsorbing the obtained concentrate with silicon dioxide, and drying to obtain the final product.
7. The method according to claim 6, wherein in step S3, the organic solvent comprises CHCl 3 Preferably, the pH is adjusted by ammonia.
8. The method according to claim 6, wherein in step S4, the acidic alcohol solution is a mixed solution of hydrochloric acid and ethanol.
9. The preparation method according to claim 8, wherein the concentration of hydrochloric acid in the acidic alcohol solution is 0.01-0.08mol/L, and the mass concentration of ethanol in the acidic alcohol solution is 40% -60%.
10. Use of a traditional Chinese medicine composition according to any one of claims 1-4 or a traditional Chinese medicine composition preparation according to claim 5 or a traditional Chinese medicine composition prepared by a method according to any one of claims 6-9 in the preparation of a product for improving the sexual desire of a drake, promoting the secretion of the sperm of a drake, improving the sperm quality of a drake or improving the reproductive performance of a drake.
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| CN113842413A (en) * | 2021-10-15 | 2021-12-28 | 上海市嘉定区中医医院 | A Chinese medicinal composition for treating male infertility |
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| CN113842413A (en) * | 2021-10-15 | 2021-12-28 | 上海市嘉定区中医医院 | A Chinese medicinal composition for treating male infertility |
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