CN116785378A - Composition and preparation for treating acne as well as preparation method and application of composition and preparation - Google Patents
Composition and preparation for treating acne as well as preparation method and application of composition and preparation Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition and a preparation for treating acne, and a preparation method and application thereof. The composition provided by the invention comprises the following raw materials: 25-30 parts of rheum officinale, 20-35 parts of fructus forsythiae, 20-25 parts of dandelion, 15-25 parts of wild chrysanthemum, 25-30 parts of red sage root, 20-25 parts of motherwort herb, 15-20 parts of spina gleditsiae, 15-20 parts of rhizoma paridis, 15-20 parts of edible tulip and 25-30 parts of selfheal. The invention has the advantages of strict compatibility, accurate syndrome differentiation, proper legislation, convenient use, safety, no toxic or side effect, high cure rate, difficult recurrence after cure and suitability for clinical popularization.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition and a preparation for treating acne, and a preparation method and application thereof.
Background
Post-pubertal acne refers to acne after 25 years of age, and is divided into two types, persistent acne (onset before 25 years of age, clinical manifestation persists until after 25 years of age) and delayed acne (onset after 25 years of age). Skin lesions are mainly acne and red inflammatory papules, have a few pustules and nodules, and are located in the perioral and mandibular areas. Traditional Chinese medicine is called acne, rosacea, pimple, facial bleb, etc.
Acne is a disease caused by multiple factors, and the onset of the acne is mainly related to the microorganism proliferation and immune response of androgens, such as the induction of excessive sebum secretion by sebaceous gland hypertrophy, abnormal keratinization of follicular duct openings, propionibacterium acnes and the like. Women after 25 years old often have stress in life, home, work and the like, and emotional disorders, irregular makeup and work and rest, unhealthy diet and the like can cause occurrence of post-pubertal acne. Therefore, the acne patients after puberty are a special group of acne onset, and have a certain practical significance for the treatment and research of the patients.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a composition, a preparation method and application for treating acne, which can effectively treat acne after puberty, and has the advantages of simple and convenient use method, safety, no toxic or side effect and high cure rate.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a composition for treating acne, which comprises the following raw materials in parts by weight: 25-30 parts of rheum officinale, 20-35 parts of fructus forsythiae, 20-25 parts of dandelion, 15-25 parts of wild chrysanthemum, 25-30 parts of red sage root, 20-25 parts of motherwort herb, 15-20 parts of spina gleditsiae, 15-20 parts of rhizoma paridis, 15-20 parts of edible tulip and 25-30 parts of selfheal.
Preferably, the material comprises the following raw materials in parts by weight: 27-30 parts of rheum officinale, 27-30 parts of fructus forsythiae, 22-25 parts of dandelion, 20-25 parts of wild chrysanthemum, 27-30 parts of radix salviae miltiorrhizae, 22-25 parts of motherwort, 17-20 parts of spina gleditsiae, 17-20 parts of rhizoma paridis, 17-20 parts of edible tulip and 27-30 parts of selfheal.
The invention provides an application of the composition in preparing a preparation for treating acne.
Preferably, the acne comprises post-pubertal acne.
The invention provides a preparation for alleviating acne symptoms, and the active ingredients of the preparation comprise the composition.
Preferably, the formulation is an external formulation.
Preferably, the external preparation comprises a mask.
The invention provides a preparation method of the composition, which comprises the following steps: pulverizing the above composition into powder to obtain the composition.
The invention provides a preparation method of a facial mask for improving acne, which comprises the following steps: mixing the powder prepared by the preparation method with mask powder and water.
Preferably, the mass volume ratio of the powder, the mask powder and the water is 15-25 g to 35-65 ml.
The beneficial effects are that: the invention provides a composition for treating acne, a preparation method and application, wherein the composition comprises the following raw materials: 25-30 parts of rheum officinale, 20-35 parts of fructus forsythiae, 20-25 parts of dandelion, 15-25 parts of wild chrysanthemum, 25-30 parts of red sage root, 20-25 parts of motherwort herb, 15-20 parts of spina gleditsiae, 15-20 parts of rhizoma paridis, 15-20 parts of edible tulip and 25-30 parts of selfheal. The invention aims to achieve the purposes of anti-inflammatory and acne removal and prevention of pigmentation and scar formation by clearing heat, resolving masses and detoxifying. The invention has the advantages of strict compatibility, accurate syndrome differentiation, proper legislation, convenient use, safety, no toxic or side effect, high cure rate, difficult recurrence after cure and suitability for clinical popularization.
Drawings
FIG. 1 is a graph showing a comparison of the positive effects of the face of a patient before and after treatment in application example 2;
FIG. 2 is a graph showing a comparison of facial side effects before and after treatment of a patient in application example 2;
FIG. 3 is a graph showing a comparison of the positive effects of the face of a patient before and after treatment in application example 3;
FIG. 4 is a graph showing a comparison of facial side effects before and after treatment of a patient in application example 3;
FIG. 5 is a graph showing a comparison of the positive effects of the face of a patient before and after treatment in application example 4;
FIG. 6 is a graph showing a comparison of facial side effects before and after treatment of a patient in application example 4;
FIG. 7 is a graph showing a comparison of the positive effects of the face of a patient before and after treatment in application example 5;
FIG. 8 is a graph showing a comparison of facial side effects before and after treatment of a patient in application example 5;
fig. 9 is a graph showing a comparison of the positive effects on the face of the patient in comparative example 1.
Detailed Description
The invention provides a composition for treating acne, which comprises the following raw materials in parts by weight: 25-30 parts of rheum officinale, 20-35 parts of fructus forsythiae, 20-25 parts of dandelion, 15-25 parts of wild chrysanthemum, 25-30 parts of red sage root, 20-25 parts of motherwort herb, 15-20 parts of spina gleditsiae, 15-20 parts of rhizoma paridis, 15-20 parts of edible tulip and 25-30 parts of selfheal.
The occurrence of the acne disclosed by the invention has close relation with wind-heat of lung channel, damp-heat of spleen and stomach, phlegm-stasis accumulation, disharmony of thoroughfare and conception vessels and the like, and the basic principles of dispelling wind and dispersing lung, clearing heat and promoting diuresis, removing stasis and resolving hard mass and harmonizing thoroughfare and conception vessels are used for treatment.
The acne of the present invention preferably comprises post-pubertal acne. The acne after puberty often accompanies the pressure in life, family, work and the like, so that emotional disorder, liver failure and excessive internal heat are caused, and liver yin is damaged; the essence and blood are homologous, and the physiological characteristics of female pregnancy and lactation are easy to consume yin and blood, yin essence is insufficient, yang is not needed to be produced, internal heat is generated, fire is excessive due to yin deficiency, and deficiency fire is flaming up to cause diseases.
The composition of the present invention comprises 25 to 30 parts by weight of rhubarb, more preferably 27 to 30 parts by weight. The invention relates to rheum officinale: bitter and cold, clear heat and dry dampness, purge fire and detoxify.
The composition of the invention comprises 20 to 35 parts by weight of weeping forsythiae capsule, and more preferably 27 to 30 parts by weight of rheum officinale. The invention relates to fructus forsythiae: bitter, slightly cold, clear away heat and toxic materials, reduce swelling and dissipate nodulation.
The composition of the present invention comprises 20 to 25 parts of dandelion herb, and more preferably 22 to 25 parts of dandelion herb, based on the weight parts of rheum officinale. The dandelion comprises the following components: bitter, sweet and cold, clearing heat and detoxicating, resolving carbuncles and resolving masses.
The composition of the present invention comprises 15 to 25 parts by weight of wild chrysanthemum flower, and more preferably 20 to 25 parts by weight of rhubarb. The invention discloses wild chrysanthemum flower: is bitter and cold, and has effects of clearing heat and detoxicating, purging pathogenic fire and suppressing hyperactive liver.
The composition of the present invention comprises 25 to 30 parts of red sage root, more preferably 27 to 30 parts, based on the weight parts of the rhubarb. The invention relates to a red sage root: bitter and cold, has the effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, cooling blood and resolving carbuncles.
Based on the weight parts of the rheum officinale, the composition comprises 20-25 parts of motherwort herb, and more preferably 22-25 parts. The invention relates to a motherwort: is bitter and cold, has the effects of promoting blood circulation, regulating menstruation, clearing heat and detoxicating.
The composition of the present invention comprises 15 to 20 parts of spina gleditsiae, more preferably 17 to 20 parts of spina gleditsiae, based on the weight parts of rheum officinale. The invention relates to spina gleditsiae: pungent and warm, detumescence, toxin expelling and pus expelling.
The composition of the present invention comprises 15 to 20 parts by weight of paris polyphylla, more preferably 17 to 20 parts by weight of rheum officinale. The invention discloses a paris polyphylla: bitter and cold, has the functions of clearing heat and detoxicating, and reducing swelling and relieving pain.
The composition of the present invention comprises 15 to 20 parts by weight of edible tulip, and more preferably 17 to 20 parts by weight of rhubarb. The invention discloses edible tulip: sweet and slightly pungent, cool, clear heat and remove toxicity, cure abscess and dissipate nodulation.
Based on the weight parts of the rheum officinale, the composition comprises 25-30 parts of selfheal, and more preferably 27-30 parts of selfheal. The invention relates to selfheal: pungent, bitter and cold, and has the actions of clearing heat, purging fire, relieving swelling and resolving masses.
In the invention, rheum officinale is a monarch drug for clearing heat and purging intense heat, cooling blood and removing toxin; fructus forsythiae and herba Taraxaci have effects of clearing heat and detoxicating, detumescence and resolving hard mass; wild chrysanthemum flower is used as ministerial drug for dispelling wind and heat and clearing away heat and toxic material; red sage root for cooling blood and eliminating carbuncle; herba Leonuri for promoting blood circulation and relieving swelling; spina gleditsiae detumescence and pus discharge; rhizoma paridis has effects of relieving swelling and pain, and is used as adjuvant drug; the edible tulip has the effects of eliminating carbuncles and resolving masses; common selfheal fruit-spike, spica Prunellae, spica, as a guiding drug, is used together to dispel the stasis and alleviate the swelling. Strict compatibility, accurate syndrome differentiation, proper legislation and symptomatic prescription, and achieves the aim of treating acne after puberty by clearing heat, purging fire, removing stasis and resolving masses.
The invention provides an application of the composition in preparing a preparation for treating acne.
The embodiment of the invention verifies the traditional Chinese medicine composition powder, proves that the traditional Chinese medicine composition powder has the effect of obviously relieving the acne symptoms after puberty, and can be applied to treating acne.
The invention provides a preparation for alleviating acne symptoms, and the active ingredients of the preparation comprise the composition.
The formulation of the present invention is preferably an external formulation. The dosage forms of the external preparation of the present invention preferably include lotions, cold cream preparations, ointments, plaster, film-coated preparations, powders, gels, aerosols. The external preparation of the present invention further preferably comprises a mask.
The invention provides a preparation method of the composition, which comprises the following steps: pulverizing the above composition into powder to obtain the composition. The crushing mode is not particularly limited, and the conventional traditional Chinese medicine crushing mode is adopted. The prepared powder is preferably sieved by a sieve with 80-120 meshes.
The invention provides a preparation method of a facial mask for improving acne, which comprises the following steps: mixing the powder prepared by the preparation method with mask powder and water. The mask disclosed by the invention is simple and easy to make, achieves the purpose of treating acne by using short time covered on the face, and has an obvious effect.
The mass volume ratio of the powder, the mask powder and the water is preferably 15-25 g, 35-65 ml, more preferably 18-22 g, 40-60 ml, and most preferably 20g, 20g and 50ml.
For further explanation of the present invention, the following describes in detail a composition, formulation, preparation method and application for treating acne provided by the present invention with reference to the accompanying drawings and examples, which should not be construed as limiting the scope of the present invention.
Example 1
The composition for treating acne is prepared from 30 parts by weight of rheum officinale, 27 parts by weight of fructus forsythiae, 25 parts by weight of dandelion, 25 parts by weight of wild chrysanthemum flower, 27 parts by weight of radix salviae miltiorrhizae, 25 parts by weight of motherwort herb, 17 parts by weight of spina gleditsiae, 17 parts by weight of rhizoma paridis, 20 parts by weight of edible tulip and 30 parts by weight of selfheal.
Preparing 20g of the composition into powder, taking 20g of mask powder, and adding 50ml of purified water to prepare into yoghurt.
Example 2
The procedure of example 1 was followed, except that 30 parts of Salvia miltiorrhiza were used.
Example 3
The procedure of example 1 was carried out except that 15 parts of Pseudobulbus Cremastrae seu pleiones were used.
Example 4
The process is carried out in the manner of example 1, except that 25 parts of selfheal are used.
Application example 1
The using method comprises the following steps: the face cleaning agent is evenly smeared on the face after cleaning, and is cleaned by clear water after 20 minutes, and the treatment is carried out for 1 time every other day, 3 times a week, and the treatment course is 4-8 weeks.
Use contraindications: the face is damaged or infected, and is not suitable for use.
The traditional Chinese medicine composition can obviously relieve acne symptoms after puberty, and has no adverse reaction.
The third edit of the invention refers to the third edit of the guidelines for clinical study of New Chinese medicine issued by the ministry of health in 1997, which develops the integral standard of skin damage symptoms, and the integral standard is shown in table 1.
Including changes in skin lesion morphology, swelling and pain, number, and color symptom score, were counted after the patient's 1 st visit and 4 weeks of treatment.
TABLE 1 integral criterion for skin lesions symptoms
The invention develops curative effect judging standard by referring to the guidelines of clinical research on new traditional Chinese medicines, and the curative effect judging standard is shown in table 2.
TABLE 2 therapeutic efficacy criterion
| Treatment efficacy determination | Skin damage condition | Symptoms of skin lesions | Symptom integration value reduction |
| Healing of the wound | The skin lesions subside, or leave only a few pigmentation | Disappearance of symptoms | ≥95％ |
| Has obvious effect | Most of the skin lesions subside | Obvious alleviation of symptoms | More than or equal to 70 percent but less than 95 percent |
| Effective and effective | Partial regression of skin lesions | Symptom improvement | More than or equal to 30 percent but less than 70 percent |
| Invalidation of | The skin damage is not obvious | Worsening of clinical symptoms | <30％ |
The calculation formula of the curative effect judgment standard comprises the following steps:
total integral = skin loss integral + symptom integral in chinese medicine.
Symptom integration value reduction= (total integration before treatment-total integration after treatment)/total integration before treatment×100%.
Total effective rate= (cure number + significant number + effective number)/total number of groups x 100%.
Application example 2
Luo Mou women, 27 years old, free occupation, 2022, 7 months of diagnosis, 1 year from said facial rash, 2 weeks aggravated cheek rash, special diagnosis.
Diagnosis of phlegm and blood stasis accumulation, legislation: clearing heat, resolving hard mass, removing blood stasis and eliminating dampness.
The mask prepared in example 1 was used in accordance with the method of application example 1. After 4 weeks of treatment, the symptoms completely disappeared, and no recurrence was observed for 6 months. The comparison effect graph before and after treatment is shown in fig. 1 and 2.
Application example 3
Qin Mou women, 28 years old, teachers, 2022, 5 months of diagnosis, patients repeatedly attack cheeks from said facial rashes for 5 years, and come to a doctor.
Diagnosis of damp-heat in intestines and stomach, legislation: clear heat, remove dampness and detoxify.
The mask prepared in example 2 was used in accordance with the method of application example 1. After 6 weeks of treatment, the symptoms completely disappeared, and no recurrence was observed for 6 months. The comparison effect of the treatment is shown in fig. 3 and 4.
Application example 4
Zhang Mou women, 25 years old, free occupation, 7 months 2022. The patients often stay up night before one year, so that the perioral and mandibular parts are scattered on acne, pustules and cysts, and aggravate in the premenstrual stage.
A dark red tongue with white and greasy coating and a wiry and slippery pulse with ecchymosis and purple spots on the side. Diagnosis of phlegm and blood stasis accumulation, legislation: clearing heat, resolving hard mass, removing blood stasis and eliminating dampness.
The mask prepared in example 3 was used in accordance with the method of application example 1. After 8 weeks of treatment, the symptoms completely disappeared, and no recurrence was observed for 6 months.
Application example 5
Ding Mou women, 28 years old, sales, 9 months 2022, patients had a doctor who had developed closed acne, pimples, pustules and gradually increased rash from the time of March due to improper cosmetics.
A red tongue with a thin and white coating and a thready and rapid pulse. Diagnosis of wind-heat type of lung meridian, legislation: dispelling wind and clearing heat.
The mask prepared in example 4 was used in accordance with the method of application example 1. After 6 weeks of treatment, the symptoms completely disappeared, and no recurrence was observed for 6 months.
Comparative example 1
Hao Mou women, 25 years old, 5 months 2022, and patients were treated by the treatment of gradually increased rash due to improper cosmetics before March and the occurrence of closed acne, pimple, pustule on cheeks.
A red tongue with a thin and white coating and a thready and rapid pulse. Diagnosis of wind-heat type of lung meridian, legislation: dispelling wind and clearing heat.
The symptoms did not improve after 4 weeks without using the mask.
The results obtained by comparing examples 2 to 4 with comparative example 1 using the evaluation criteria provided in application example 1 are shown in Table 3.
Table 3 evaluation Standard results
| Integral of treatment of pre-cutaneous lesions | Integral of post-treatment skin lesions symptoms | Rate of healing | |
| Application example 2 | 4 | 0 | Healing of the wound |
| Application example 3 | 6 | 0 | Healing of the wound |
| Application example 4 | 4 | 0 | Healing of the wound |
| Application example 5 | 6 | 0 | Healing of the wound |
| Comparative example 1 | 4 | 0 | Healing of the wound |
Application example 6
According to the invention, 30 cases are counted according to the plan, 15 cases are treated in a treatment group and 15 cases are treated in a control group. The following comparisons were made:
1. integral comparison of symptoms before and after treatment of the treatment group;
2. the integral comparison of symptoms before and after the treatment of the control group;
3. the integral comparison of symptoms before treatment of the two groups;
4. the integral comparison of symptoms after two groups of treatments;
5. the two groups were compared for cure rate.
The results of the comparison are shown in tables 4 to 8.
TABLE 4 score comparison of symptoms before and after treatment of treatment groups
| 0 point | 2 minutes | 4 minutes | 6 minutes | |
| Before treatment (human) | 0 | 3 | 6 | 6 |
| After treatment (human)) | 13 | 2 | 0 | 0 |
Table 5 comparison of the integral of symptoms before and after treatment in the control group
| 0 point | 2 minutes | 4 minutes | 6 minutes | |
| Before treatment (human) | 0 | 4 | 5 | 6 |
| After treatment (human) | 6 | 6 | 3 | 0 |
Table 6 comparison of the score of symptoms before treatment for two groups
| 0 point | 2 minutes | 4 minutes | 6 minutes | |
| Treatment group (human) | 0 | 3 | 6 | 6 |
| Control group (human) | 0 | 4 | 5 | 6 |
Table 7 comparison of the integral of symptoms after two treatment groups
Table 8 comparison of the two sets of cure rates
| Healing of the wound | Has obvious effect | Effective and effective | Invalidation of | Rate of more visible (%) | |
| Treatment group | 10 | 5 | 0 | 0 | 100％ |
| Control group | 6 | 5 | 2 | 2 | 86.67％ |
The comparison result shows that the facial mask prepared from the composition for treating acne is safe, free of toxic and side effects, high in cure rate, not easy to relapse after healing, and suitable for clinical popularization.
Although the foregoing embodiments have been described in some, but not all, embodiments of the invention, it should be understood that other embodiments may be devised in accordance with the present embodiments without departing from the spirit and scope of the invention.
Claims (10)
1. The composition for treating acne is characterized by comprising the following raw materials in parts by weight: 25-30 parts of rheum officinale, 20-35 parts of fructus forsythiae, 20-25 parts of dandelion, 15-25 parts of wild chrysanthemum, 25-30 parts of red sage root, 20-25 parts of motherwort herb, 15-20 parts of spina gleditsiae, 15-20 parts of rhizoma paridis, 15-20 parts of edible tulip and 25-30 parts of selfheal.
2. The composition according to claim 1, characterized by comprising the following raw materials in parts by weight: 27-30 parts of rheum officinale, 27-30 parts of fructus forsythiae, 22-25 parts of dandelion, 20-25 parts of wild chrysanthemum, 27-30 parts of radix salviae miltiorrhizae, 22-25 parts of motherwort, 17-20 parts of spina gleditsiae, 17-20 parts of rhizoma paridis, 17-20 parts of edible tulip and 27-30 parts of selfheal.
3. Use of a composition according to claim 1 or 2 for the preparation of a formulation for the treatment of acne.
4. The use according to claim 3, wherein the acne comprises post-pubertal acne and adolescent acne.
5. A formulation for alleviating symptoms of acne, wherein the active ingredient of the formulation comprises the composition of claim 1 or 2.
6. The formulation of claim 5, wherein the formulation is an external formulation.
7. The formulation of claim 6, wherein the topical formulation comprises a mask.
8. A process for the preparation of a composition according to claim 1 or 2, characterized in that it comprises the following steps: crushing the composition according to claim 1 or 2 into powder to obtain the composition.
9. The preparation method of the acne-improving mask is characterized by comprising the following steps of: the powder prepared by the preparation method of claim 8 is mixed with mask powder and water.
10. The method for preparing the mask according to claim 9, wherein the mass-volume ratio of the powder to the mask powder to the water is 15-25 g/35-65 ml.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720865A (en) * | 2013-12-20 | 2014-04-16 | 张翠月 | Traditional Chinese medicinal facial mask for treating acne and preparation method of facial mask |
| CN103860866A (en) * | 2012-12-13 | 2014-06-18 | 薛文涛 | Traditional Chinese medicine composition for treating acne |
| CN104587198A (en) * | 2014-12-29 | 2015-05-06 | 辛怡静 | Traditional Chinese medicine composition for treating acne |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860866A (en) * | 2012-12-13 | 2014-06-18 | 薛文涛 | Traditional Chinese medicine composition for treating acne |
| CN103720865A (en) * | 2013-12-20 | 2014-04-16 | 张翠月 | Traditional Chinese medicinal facial mask for treating acne and preparation method of facial mask |
| CN104587198A (en) * | 2014-12-29 | 2015-05-06 | 辛怡静 | Traditional Chinese medicine composition for treating acne |
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