CN116754782A - High-flux sample detection method and detection system - Google Patents
High-flux sample detection method and detection system Download PDFInfo
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
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- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
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- G01N2035/0439—Rotary sample carriers, i.e. carousels
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Abstract
The invention relates to a high-flux sample detection method and a detection system; according to the invention, a double-component structural layout is adopted, two groups of mechanical devices alternately execute detection actions and circulate according to a detection period, the multi-project combined detection method can complete detection tasks of more biological samples in unit time, the detection flux and the detection efficiency are improved, the detection speed of 600 projects/hour or more is reached, the requirements of the existing detection tasks are met, the degree of automation is high, and the high-flux biological sample detection analysis is realized; the modularized reasonable layout is convenient for realizing parallel operation, further widens the detection channel, has high integration level, small space occupation, higher utilization rate and wide application range, and is convenient for popularization and use in laboratories, hospitals and the like.
Description
Technical Field
The invention relates to the technical field of biological sample detection and analysis, in particular to a high-flux sample detection method and a detection system.
Background
The common biological sample analysis device comprises a biochemical analyzer, a hemoglobin analyzer, an immunity analyzer, a coagulation analyzer and the like, is used for analyzing the composition of the substance components of the biological sample to be detected, and is widely applied to the analysis and research in the clinical detection and biological fields; for example, the coagulation analyzer clinically performs coagulation and anticoagulation, fibrinolysis and antifibrinolysis analysis on a blood sample of a patient, has important diagnostic value on hemorrhagic diseases, thrombotic diseases, DIC and liver and kidney diseases, and plays an important role in preoperative inspection and anticoagulation quality detection.
Such sample analyzers typically add a biological sample to a cuvette, add a detection reagent to assist in incubation, washing, or/and mixing, and measure parameters such as concentration and chemical properties of each component by a physical detection method. In the existing sample detection, the excessive number of samples leads to overlong detection time, so that the preservation cost of the samples is increased, the activity of biological samples is easily damaged, and the accuracy and timeliness of detection results are affected; the detection flux of the current large-scale coagulation analyzer is about 300-450 items/hour, and is difficult to break through to higher flux, and when the detection task amount of the clinical laboratory of the hospital is large, more detection items can not be completed in unit time; meanwhile, the existing sample analysis device is large in size to improve flux, occupies more space and is not beneficial to popularization and application of laboratory research.
Disclosure of Invention
Therefore, the technical problems to be solved by the invention are to overcome the technical difficulties of small detection flux, low detection speed and large occupied space of the device of the biological sample analysis device in the prior art, and provide a high-flux sample detection method and a detection system, wherein the detection flux is improved by alternately executing actions by using a two-component layout, and the space utilization rate is improved by integrating the layout.
In a first aspect, the present invention provides a high throughput sample detection method, which comprises the following steps,
step 1: the empty reaction cups are sequentially arranged in the cup arranging assembly, and the empty cup grippers grasp the empty cup I from the cup arranging assembly and are placed in the placing holes I of the reaction cup transmission line; the empty cup gripper starts t 0 After seconds, the empty cup gripper grabs the empty cup II from the cup arranging assembly and places the empty cup II on a placement Kong Erzhong of a reaction cup transmission line;
step 2: a first sample needle aspirates a sample and doses it into the first empty cup; the first sample needle is started to be t 0 After seconds, a second sample needle sucks a sample and quantitatively distributes the sample into the second empty cup;
step 3: the second reaction cup gripper grabs the first reaction cup in the first placing hole and places the first reaction cup in the first incubation plate for treatment; the second reaction cup gripper starts t 0 After seconds, the first reaction cup gripper grabs a second reaction cup in the second placement hole and places the second reaction cup in a second incubation plate for treatment;
step 4: the first reaction cup gripper is used for placing the processed sample in the first incubation tray into a first test module for testing, and executing a cup losing action after the testing is completed; the first reaction cup gripper starts t 0 After seconds, a third reaction cup gripper places the processed sample in the second incubation plate in a second test module for testing; the first test module tests to complete t 0 After seconds, the second testing module completes testing and executes the cup losing action;
step 5: repeating the steps 1-4; wherein the detection period of each sample is T, T 0 ＝0.5T。
In one embodiment of the present invention, in step 3, the sample is sequentially subjected to an intermediate reagent treatment and an initiation reagent treatment after the incubation treatment;
a second reaction cup gripper grabs a first reaction cup in the first incubation tray to a first intermediate reagent needle position, distributes intermediate reagents, mixes the intermediate reagents uniformly and then returns the intermediate reagents to the first incubation tray; after the intermediate reagent treatment is finished, the first reaction cup is grabbed by the first reaction cup grab to the first starting reagent needle position, and the sample treatment is finished after the starting reagent is distributed and uniformly mixed;
the second reaction cup gripper starts t 0 After seconds, the third reaction cup gripper grabs a second reaction cup in the second incubation tray to a second intermediate reagent needle position, and the intermediate reagent is distributed, mixed uniformly and then returned to the second incubation tray; after the intermediate reagent treatment is finished, the third reaction cup is grabbed by the grabbing hand to the position of the second starting reagent needle, and the sample treatment is finished after the starting reagent is distributed and uniformly mixed.
In one embodiment of the present invention, the sample detection period is T+t 1 At time t 0 ＝0.5T+t 1 。
In a second aspect, the present invention also provides a high throughput sample detection system for detection using the detection method of any of the embodiments described above, the detection system comprising a control system and at least one set of detection devices, the control system being connected to and controlling the operation of the detection devices, each of the detection devices comprising,
the reaction cup supply module comprises the cup arranging assembly and the reaction cup transmission line and is used for bearing the empty reaction cup;
a sample supply module comprising a sample transfer assembly and a sample needle assembly, the sample needle assembly comprising the first and second sample needles driven by a sample needle robotic arm for sampling and sample dispensing, respectively;
a sample processing module comprising an incubation assembly and a reagent supply assembly that provides an intermediate reagent and an initiation reagent for sample processing;
the detection module is used for detecting the samples processed by the sample processing module;
the gripper module comprises the empty cup gripper, the first reaction cup gripper, the second reaction cup gripper and the third reaction cup gripper, and the second reaction cup gripper and the incubation assembly rotate around the same rotating shaft; the gripper module is used for grabbing the reaction cup to conduct sample supply, sample processing and detection.
In one embodiment of the invention, the sample transfer assembly comprises a test track, a transfer track, and a recovery track arranged in parallel; wherein the conveying direction of the test track and the conveying track is the same, and the conveying direction of the recovery track and the test track is opposite; the transmission track is used for transmitting the sample rack to other detection devices in the detection system; the recovery track is used for recovering the sample rack in the detection system; the first sample needle and the second sample needle are driven by the sample needle mechanical arm connected with the first sample needle and the second sample needle to conduct circular motion respectively, and the paths of the circular motion intersect at the sampling point of the test track.
In one embodiment of the invention, the reagent supply assembly comprises a reagent bottle carrier and a loading unit; the reagent bottle carrier comprises at least two groups of reagent bottle tracks which are concentrically arranged, and the reagent bottle tracks are used for placing reagent bottles; the loading unit conveys the reagent bottles to the reagent bottle carrying platform through the loading mechanical arm, and the loading unit can rotate and is movably connected with the side wall of the detection device.
In one embodiment of the invention, the first intermediate reagent needle, the second intermediate reagent needle, the first priming reagent needle, the second priming reagent needle, and the first sample needle and the second sample needle are each driven past the reagent bottle track.
In one embodiment of the invention, the first, second and third cuvette grippers are each equipped with an eccentric stirring motor; the first starting reagent needle and the second starting reagent needle are internally provided with reagent temperature control mechanisms.
In one embodiment of the invention, the incubation assembly comprises the first incubation tray and a second incubation tray; the first incubation tray and the second incubation tray coaxially rotate and are respectively connected with an incubation tray driving part, and the first incubation tray and the second incubation tray are respectively connected with an incubation temperature control mechanism.
In one embodiment of the invention, the control system includes a periodic test control module that controls the detection interval time t of the detection device 0 The method comprises the steps of carrying out a first treatment on the surface of the The control system is connected with a display screen of the detection device to output control information.
Compared with the prior art, the technical scheme of the invention has the following advantages:
according to the high-flux sample detection method and the high-flux sample detection system, a double-component structure layout is adopted, two groups of mechanical devices alternately execute detection actions and circulate according to a detection period, the multi-project combined detection method can complete detection tasks of more biological samples in unit time, detection flux and detection efficiency are improved, detection speed of 600 projects/hour or more is achieved, the requirements of the existing detection tasks are met, the degree of automation is high, and high-flux biological sample detection analysis is realized;
the high-throughput sample detection method and the detection system are suitable for various analysis devices such as a coagulation analyzer, the two-component structure is integrated in the same device, the two-component structure is in modularized reasonable layout and convenient to realize parallel operation, the detection channel is further widened, the integration level is high, the space occupation is small, the utilization rate is high, the application range is wide, and the method and the system are convenient to popularize and use in laboratories, hospitals and the like.
Drawings
In order that the invention may be more readily understood, a more particular description of the invention will be rendered by reference to specific embodiments thereof which are illustrated in the appended drawings, in which:
FIG. 1 is a schematic diagram of an operation flow of a two-component driving layout according to a first embodiment of the present invention;
FIG. 2 is a schematic diagram of an exploded motion flow of a two-component driving layout in accordance with a first embodiment of the present invention;
FIG. 3 is a flow chart illustrating dynamic adjustment of cycle time in accordance with the first embodiment of the present invention;
FIG. 4 is a schematic layout diagram of a detecting device according to a second embodiment of the present invention;
FIG. 5 is an enlarged schematic view of the layout shown in FIG. 4;
FIG. 6 is a schematic diagram of a control system according to a second embodiment of the present invention;
FIG. 7 is a schematic diagram of a control system according to a second embodiment of the present invention;
FIG. 8 is a schematic diagram of a detection system according to a third embodiment of the present invention;
FIG. 9 is a schematic layout of a detecting device in a third embodiment of the present invention;
fig. 10 is a schematic flow chart of a control system in the third embodiment of the invention.
Description of the specification reference numerals:
1. a reaction cup supply module; 11. a cup arranging assembly; 12. a reaction cup transmission line; 13. a reaction cup;
2. a sample supply module; 21. a sample transmission assembly; 211. a transmission track; 212. recovering the track; 213. testing the track; 214. a sample rack; 215. a biological sample container; 22. a sample needle assembly; 221. a first sample pin; 222. a second sample needle; 223. sampling points; 23. a sample rack storage area; 24. the sample rack emergency treatment area; 25. a sample rack scheduling platform; 26. a sample rack scanning area; 27. an inlet; 28. an outlet;
3. a sample processing module; 31. a first intermediate reagent needle; 32. a second intermediate reagent needle; 33. a first priming reagent needle; 34. a second priming reagent needle;
4. an incubation assembly; 41. a first incubation plate; 42. a second incubation plate;
5. a reagent supply assembly; 51. a reagent bottle carrier; 52. a loading unit; 53. loading a mechanical arm; 54. a reagent bottle track;
6. a detection module; 61. a first test module; 62. a second test module; 63. a cup throwing hole;
71. a first reaction cup gripper; 72. a second reaction cup gripper; 73. a third reaction cup gripper;
8. an industrial control board;
9. and a display screen.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and specific examples, which are not intended to be limiting, so that those skilled in the art will better understand the invention and practice it.
Example 1
Referring to fig. 1 to 3, a first embodiment of the present invention provides a high-throughput sample detection method, which has higher throughput, higher detection speed and better efficiency than the existing biological sample detection method, and the detection method includes the following steps:
step 1: the step 1 is set to be a reaction cup supply. The method comprises the steps that a plurality of irregularly placed empty reaction cups 13 are arranged in sequence through a cup arranging assembly 11, the empty reaction cups 13 are configured to be placed upwards in an opening to-be-detected state through the cup arranging assembly 11, the empty reaction cups 13 are transmitted to the upper side of a reaction cup supply module 1 through a conveying chain, at the moment, the empty reaction cups 13 are obliquely arranged and slide into a cup arranging slope under the action of gravity, two reflection sensors are arranged in the cup arranging slope and used for detecting the internal state of the empty reaction cups 13 on the cup arranging slope, and then the movement or stop of the conveying chain is controlled through a stepping motor; a cup supplementing assembly is arranged at the interface below the cup arranging slope and used for rotating the empty reaction cup 13 of the cup arranging slope into a new position, and an empty cup gripper is used for grabbing an empty cup I at the new position and is placed in a placement hole I of the reaction cup transmission line 12; starting t at the empty cup gripper 0 After seconds, the empty cup gripper grips the empty cup II from the position and places the empty cup II in the placement hole II of the reaction cup transmission line 12.
Step 2: said step 2 is arranged as a sample supply. After the first empty cup is grasped by the first empty cup gripper and placed in the first placement hole, the first empty cup is immediately transported to the position of the first sample needle 221 through the reaction cup transport line 12, and the first sample needle 221 is driven by the sample needle mechanical arm to suck a quantitative biological sample and is distributed to the first empty cup.
After the second empty cup is grasped and placed in the second placement hole by the empty cup gripper, the second empty cup is immediately transmitted to the position of the second sample needle 222 through the reaction cup transmission line 12; start t at the first sample needle 221 0 After seconds, the second sample needle 222 is driven by the sample needle robotic arm to aspirate a quantity of biological sample and dispense to the second empty cup.
Step 3: said step 3 is set to sample processing. Immediately after the first empty cuvette is allocated with the biological sample, the first empty cuvette is transferred to the position of the second cuvette gripper 72 through the cuvette transfer line 12, and the second cuvette gripper 72 is driven by the gripper driving arm to grasp the first cuvette with the sample stored in the first placement hole and grasp the first cuvette with the sample stored in the first placement hole, and the first cuvette is incubated in the cuvette hole of the first incubation tray 41.
Immediately after the second cuvette is allocated with the biological sample, the second cuvette is transported to the position of the first cuvette grip 71 through the cuvette transport line 12; starting t at the second cuvette grip 72 0 After seconds, the first cuvette gripper 71 is driven by the gripper driving arm to grip the second cuvette with the sample stored in the second placement hole, and grips the second cuvette with the sample stored in the second placement hole, and the second cuvette is incubated in the cuvette hole of the second incubation tray 42.
Further, after the first reaction cup is incubated for a certain period of time, the first reaction cup enters an intermediate reagent treatment stage, a second reaction cup gripper 72 grabs the first reaction cup in the first incubation tray 41 to a position a where the first reaction cup interacts with the first intermediate reagent needle 31, a fixed amount of intermediate reagent is distributed through the first intermediate reagent needle 31, and after being evenly mixed, the first reaction cup gripper is put back into the first incubation tray 41 to continue to incubate the designated period configured by the first incubation tray 41; after the first reaction cup completes the incubation treatment of the intermediate reagent, entering a reagent starting treatment stage, and the first reaction cup gripper 71 grabbing the first reaction cup and transporting the first reaction cup to a position c where the first reagent starting needle 33 interacts with the first reaction cup gripper; the first starting reagent needle 33 sucks the starting reagent and heats the starting reagent, distributes the starting reagent to the first reaction cup after heating to a designated temperature, and completes sample processing in the first reaction cup after uniform mixing.
After a certain time of incubation of the second cuvette, an intermediate reagent treatment phase is entered, and the second cuvette gripper 72 initiates the intermediate reagent treatment phase t of the first cuvette 0 After seconds, the third reaction cup gripper 73 grips the second reaction cup in the second incubation tray 42 to a position b where the second reaction cup interacts with the second intermediate reagent needle 32, a fixed amount of intermediate reagent is dispensed through the second intermediate reagent needle 32, and after being mixed uniformly, the second reaction cup gripper is put back into the second incubation tray 42 to continue to incubate for a designated time allocated to the second incubation tray 42; after the second reaction cup completes the incubation treatment of the intermediate reagent, the second reaction cup enters a reagent starting treatment stage, and the first reaction cup gripper 71 starts the reagent starting treatment of the first reaction cupStage t 0 After seconds, the third reaction cup gripper 73 grips the second reaction cup to a position d where the second reaction cup gripper interacts with the second starting reagent needle 34, the second starting reagent needle 34 absorbs the starting reagent and heats the starting reagent, the starting reagent is distributed to the second reaction cup after being heated to a specified temperature, and the sample processing in the second reaction cup is completed after uniform mixing.
Step 4: the step 4 is set up for sample detection. The first reaction cup gripper 71 places the first reaction cup processed in the step 3 in a specified test hole of the first test module 61 for testing, in some embodiments, the first test module 61 is set as an optical detection unit, the test hole is located in a first light path component, the reaction liquid in the first reaction cup is sequentially irradiated with monochromatic light according to time sequence, then a photoelectric receiver is utilized to monitor the light intensity of the monochromatic light in real time and linearly convert the AD value, the AD value change process and the reaction intensity degree of the reaction liquid in the first reaction cup or the substance concentration of the reaction liquid are in certain correlation, a reaction curve is drawn through a computer program, an algorithm is performed on the reaction curve to obtain a relevant detection report for completing the test, and the cup losing action is executed in the first cup losing hole 63.
Starting t at the first cuvette grip 71 0 After seconds, the third cuvette holder 73 places the second cuvette after the sample processing in step 3 in the specified test hole of the second test module 62 for testing; the testing process is the same as that of the first reaction cup, and will not be described again. The first test module 61 tests completion t 0 After seconds, the second test module 62 completes the test and performs the cup dropping operation from the second cup dropping hole 63.
Step 5: repeating the steps 1-4; wherein the detection period of each sample is T, T 0 =0.5t. In the detection method of the embodiment, the action flow of mechanical driving includes an empty reaction cup transmission grabbing action, a sample needle distribution sample action, an intermediate reagent needle quantitative distribution action, a reagent needle quantitative distribution starting action, an optical path detection unit executing the optical signal AD value acquisition of the period, and a cup losing action after the optical path detection unit completes the test; using a first set of machinesThe robot arm driving hand, the first sample needle 221, the first intermediate reagent needle 31 and the first starting reagent needle 33 perform the above-mentioned actions, and the time when the second group of robot arm driving hand, the second sample needle 222, the second intermediate reagent needle 32 and the second starting reagent needle 34 perform the above-mentioned actions are all separated by t 0 Two groups of mechanical arms for executing actions aiming at the first reaction cup and the second reaction cup are separated by t 0 And (5) periodically and alternately executing the control flow and repeating the control flow according to the rule. Wherein t is 0 =0.5t, t represents the execution cycle time of the whole set of robotic arms; when the detection period of each sample is T, the two groups of samples are alternately detected at intervals of 0.5T, so that the detection efficiency and the detection flux can be improved, and the execution time is staggered to provide switching time for sample supply, intermediate reagent supply and starting reagent supply; meanwhile, referring to fig. 1 and 2, when the interval time is half a period, the detection process driven by the first group of mechanical arms and the detection process driven by the second group of mechanical arms are both circulated without intermittent time, so that the overall detection efficiency is ensured. In some embodiments, the detection cycle time is set to be 12 seconds, so that the execution interval time of the two groups of mechanical arm driving mechanisms is 6 seconds, the interval time of detection results is shortened by the detection flow which is performed alternately, after the first sample item after starting is tested, a new sample test item is completed every 6 seconds, the detection efficiency is improved by setting the two sample item detection channels which are performed alternately, and the overall detection speed can reach 600 items at a constant speed per hour; in other embodiments, the detection period may be changed according to the sample detection requirement and the change of the detection flow, so that the period time is not limited to 12 seconds, the overall detection speed can be further improved, and the purpose of high-throughput detection is achieved.
Further, referring to fig. 3, in some embodiments, due to the fact that the sample has a low requirement on the detection speed due to the abnormal operation flow, or the sample to be detected needs a longer period time to complete the detection, the detection period of a certain sample exceeds the detection period time t of other items 1 When the period time of the item needs to be dynamically adjusted to be T+t 1 When in use, the embodiment is described inThe detection method can also dynamically adjust the starting execution time of the next item from interval 0.5T to interval 0.5T+t 1 I.e. t of the next item 0 ＝0.5T+t 1 The method comprises the steps of carrying out a first treatment on the surface of the The test flow of the subsequent project can still be alternately performed at intervals of 0.5T, the influence of the detection delay of a certain project is avoided, and the ordered and high-efficiency of the whole detection is ensured.
Example two
Referring to fig. 4 to 7, a second embodiment of the present invention provides a high throughput sample detection system for detecting a biological sample by the detection method as in the first embodiment; the detection system comprises a control system and a group of detection devices, and referring to fig. 4, the detection devices comprise a reaction cup supply module 1 for supplying reaction cups, a sample supply module 2 for supplying samples, a sample processing module 3 for processing the samples, a detection module 6 for detecting and a gripper module for executing an action flow; the detection device is intelligently controlled by the control system to allocate, so that the detection efficiency is ensured, the detection device integrates two groups of mechanical arms for executing actions, two groups of project detection can be alternately performed in one detection device, the integration level is better, the space utilization rate is improved, and the detection system in the embodiment can be widely applied to various scenes such as laboratories, hospitals and the like.
Specifically, referring to fig. 6, the control system includes a sample information management module, a reagent information management module, a period test control module, a system information setting module, an equipment maintenance function module, and a calibration and quality control management module; the periodic test control module is used for controlling the detection interval time of the two groups of mechanical arms, controlling the interval execution time of the next detection item after the detection period of some detection items is prolonged, and reasonably scheduling the two groups of mechanical arms. The control system is configured in the industrial control board 8, the industrial control board 8 is installed in the detection device, and the industrial control board 8 is connected with the display screen 9 and can output and display detection information such as detection speed, samples, reagents and the like.
Further, referring to fig. 10, a schematic diagram of a framework of the control system in the second embodiment is shown, where the information system is responsible for the information input, the result report, the test process and the result display of the test application biological sample, the reagent sealing interaction, the LIS communication, the data statistics and the equipment connection status; the information number of the biological sample is obtained through manual input or an information system bar code scanning mode, then the test item information of the biological sample is obtained from a laboratory LIS system, the information system generates a test task and then receives the test task, a host computer starts the test of the biological sample according to a software algorithm flow, and a response curve is obtained for data analysis and calculation, so that a report result is obtained and reported. The detection device host unit is responsible for receiving and executing the test tasks of the information system and has all necessary functions of single machine operation.
Specifically, referring to fig. 4, the cuvette feeding module 1 includes the cuvette handling assembly 11 and the cuvette transfer line 12, and is configured to carry the empty cuvette 13; the reaction cup transmission line 12 is configured as a one-dimensional motion mechanism and is driven by a stepping motor, and the reaction cup transmission line 12 is provided with placement holes for placing the empty reaction cups 13 in an aligned manner, and in some embodiments, the placement holes at least comprise a placement hole I for placing the empty cup I and a placement hole II for placing the empty cup II.
Specifically, referring to fig. 4, the sample supply module 2 includes a sample transmission assembly 21 and a sample needle assembly 22; the sample transmission assembly 21 comprises a transmission track 211 and a recovery track 212 which are arranged in parallel and have opposite transmission directions, and a test track 213 which is arranged in parallel with the transmission track 211 and is transmitted in the same direction; the dispatching system is responsible for automatically loading the sample rack 214 into the transmission track 211 and providing an interface for an information system, dispatching the sample rack 214 among an in-out rack, a buffer zone and a rear track according to the indication of the information system, wherein the transmission track 211 is used for transmitting the sample rack 214 to the detection device at the next position in the detection system, and the recovery track 212 is used for recovering the sample rack 214; the sample rack 214 has a biological sample container 215 disposed thereon to provide a sample to be tested for easy aspiration by the sample needle assembly 22.
Further, referring to fig. 4, the sample needle assembly 22 includes the first sample needle 221 and the second sample needle 222, and the first sample needle 221 and the second sample needle 222 are driven by a sample needle mechanical arm to aspirate a sample from a blood collection tube or a sample container and dispense the sample into a reaction cup; the first sample needle 221 and the second sample needle 222 are driven by the sample needle mechanical arm connected with the first sample needle to perform circular motion, and the paths of the circular motion intersect at a sampling point 223 of the test track 213, and the sampling point 223 is provided with the biological sample container 215. The mechanical arms driving the first sample needle 221 and the second sample needle 222 are both provided with a T/Z two-dimensional rotating mechanical arm structure, so that the height of the sampling needle in the vertical direction can be adjusted, and meanwhile, the circular motion can be intersected with the transmission track 211 and the reaction cup transmission line 12 to sample and distribute.
Specifically, referring to fig. 4, the sample processing module 3 includes an incubation assembly 4 and a reagent supply assembly 5; the reagent supply assembly 5 is used for providing an intermediate reagent and an activating reagent for a sample, and the reagent supply assembly 5 comprises a reagent bottle carrier 51 and a loading unit 52; the loading unit 52 conveys reagent bottles to the reagent bottle carrying table 51 through a loading mechanical arm 53 and is orderly arranged on a reagent bottle track 54, the reagent bottles have a capacity of about 15ml and are used for containing intermediate reagents or starting reagents, and the reagent bottles are refrigerated in the reagent bottle carrying table 51 to ensure activity, and the refrigerated temperature is lower than 16 ℃. The reagent bottle carrying platform 51 adopts a disc-shaped structure and comprises at least two groups of reagent bottle tracks 54 which are concentrically arranged, and the reagent bottle tracks 54 can independently rotate; the loading mechanical arm 53 grabs the reagent bottles through a claw-pointing mechanism and places the reagent bottles on the reagent bottle track 54 for automatic loading. The reagent bottle carrier 51 can hold a single reagent container and a double reagent container, and the single reagent container can hold the double reagent container, thereby improving the loading capacity.
Further, referring to fig. 8, a man-machine interaction window is further provided beside the reagent bottle carrier 51, the man-machine interaction window is located on the side wall of the detection device, the loading unit 52 is movably connected with the man-machine interaction window on the side wall of the detection device, and the loading unit can extend out of the detection device through the window, so that reagent bottles can be conveniently taken and placed manually; in some embodiments, the loading unit 52 can be driven to rotate around a shaft, so as to facilitate taking and placing materials at the same position; when the loading unit 52 stops rotating, it can also be pulled out from the device host to be conveniently loaded, a drawer type loading disc with a pulling function is arranged, an operator places reagent bottles on the loading disc, after the drawer type loading disc is pushed into the machine, an automatic loading mechanical arm is arranged into an XZ two-dimensional linear motion structure, and the mechanical arm grabs reagent bottles positioned in the loading disc through electric claws to be placed in the reagent bottle track 54. A first intermediate reagent needle 31, a second intermediate reagent needle 32, a first priming reagent needle 33, a second priming reagent needle 34, and the first sample needle 221 and the second sample needle 222 are each driven through the reagent bottle track 54 to aspirate reagent, the first sample needle 221 and the second sample needle 222 being capable of aspirating sample diluent from the reagent supply assembly 5; the first starting reagent needle 33 and the second starting reagent needle 34 are both internally provided with a reagent temperature control mechanism, so that the sucked starting reagent is quickly preheated and thermostatically controlled, and is heated to a specified temperature. The mechanical arms driving the first middle reagent needle 31, the second middle reagent needle 32, the first starting reagent needle 33 and the second starting reagent needle 34 all use X/Z two-dimensional linear motion, so that the reagent needles can move between the reagent bottle and the sample interaction position along the horizontal direction, and the reagent can be quantitatively sucked by controlling the position in the vertical direction through the suspension arm structure, the device is simple in design, compact in structure and high in automation degree, and the internal space utilization rate is optimized.
Further, referring to fig. 4, the incubation assembly 4 includes a first incubation plate 41 and a second incubation plate 42; heating and incubating the sample to enable the temperature of the sample or the mixed solution to reach a preset temperature; in some embodiments, the first incubation plate 41 and the second incubation plate 42 are both configured as a disc structure, and are concentrically arranged and rotate around the same rotation axis, and the first incubation plate 41 and the second incubation plate 42 are both provided with reaction cup holes in a circumferential direction; in some embodiments, the radius of the second incubation disc 42 is smaller than that of the first incubation disc 41, the first incubation disc 41 is sleeved on the periphery of the second incubation disc 42, 40 reaction cup holes are circumferentially formed in the first incubation disc 41, 30 reaction cup holes are circumferentially formed in the second incubation disc 42, and the number of the reaction cup holes of the incubation assembly 4 varies with the volume of the detection device and the total number of items detected, which is not limited thereto. Further, each of the first incubation tray 41 and the second incubation tray 42 is connected to an incubation tray driving section, and the rotation of the two incubation trays is independent; the first incubation tray 41 and the second incubation tray 42 are respectively connected with an incubation temperature control mechanism, and the incubation temperature control mechanism comprises a heating device and a temperature sensor; the first incubation tray 41 and the second incubation tray 42 independently control the incubation temperature through the incubation temperature control mechanism so as to meet the incubation conditions of different samples. In some embodiments, the incubation temperature control mechanism adopts a 30W/24V silica gel heating film as a heating device, realizes constant temperature control through a control software PID control algorithm, and comprises heat preservation cotton at the periphery of an incubation plate to reduce heat dissipation; in some embodiments the incubation temperature of the biological sample in the incubation assembly 4 is set to a constant temperature of 37 ℃ ± 0.5 ℃.
Specifically, referring to fig. 4, the detecting module 6 is configured to detect the sample processed by the sample processing module 3. In the third embodiment of the present invention, the detection module 6 is configured as an optical detection means, and includes two groups of optical path components disposed on two sides of the incubation component 4; the first test module 61 and the second test module 62 are both configured with the optical path component, and have optical measurement units with multiple wavelength light selectable and multiple test channels, and the light intensity variation in the reaction process is monitored by irradiating the reaction liquid with monochromatic light to form a reaction data curve, then the reaction curve is analyzed by methods such as a solidification method, an immunoturbidimetry method or a chromogenic substrate method, and the detection result is output by calculation results of a computer program to obtain a solidification reaction or a rate method curve which varies with time, so as to calculate relevant characteristic parameters of solidification time or other methods; the method can collect optical signals of various biological samples bearing physiological information of the biological samples simultaneously in extremely short time. In some embodiments, each light path assembly is provided with 16 equally spaced detection apertures, each configured with at least 4 wavelengths of monochromatic light, at least meeting the detection capability of 4 wavelengths of monochromatic light.
Specifically, referring to fig. 4, the gripper module includes the empty cup gripper, the first cuvette gripper 71, the second cuvette gripper 72, and the third cuvette gripper 73; the gripper module is used for gripping the reaction cup to perform sample supply, sample processing and detection, and the first reaction cup gripper 71, the second reaction cup gripper 72 and the third reaction cup gripper 73 are respectively provided with an eccentric wheel stirring motor, so that the sample and the intermediate reagent in the reaction cup can be quickly mixed while the reaction cup is gripped, or the sample and the starting reagent after the intermediate reagent treatment in the reaction cup are quickly mixed; further, the second reaction cup gripper 72 is configured as a TYZ rotary three-dimensional driving structure, which rotates around the same rotation axis with the incubation component 4 and can move in the vertical direction, so when the second reaction cup is gripped, the second reaction cup gripper 72 first grips the second reaction cup gripper above the extension plane of the second incubation plate 42, and then places the second reaction cup gripper into the incubation hole in the second incubation plate 42. The first cuvette grip 71 and the third cuvette grip 73 are each arranged in an XYZ three-dimensional driving structure.
Example III
Referring to fig. 8 to 9, a third embodiment of the present invention further provides a high-throughput sample detection system, which is different from the second embodiment only in that a control system is used to control a plurality of detection device hosts for parallel operation; in some embodiments, the detection system comprises two detection device hosts and the sample injection unit provides centralized sample injection, and the two detection devices can realize the detection speed of 1200 items per hour; in other embodiments, the detection device host can be configured as a four device parallel operation or a multi-module parallel operation layout, but is not limited thereto.
Referring to fig. 9, the sample introduction unit includes a sample rack storage area 23, a sample rack emergency area 24, a sample rack scheduling platform 25, and a sample rack scanning area 26. The sample rack storage area 23 is configured with 4 trays, each of which can hold 6 sample racks 214; the sample rack storage area 23 is used for storing a biological sample to be tested or storing a biological sample to be retested; the emergency area 24 is used for storing biological samples to be tested in emergency or in priority, and is provided with two sample rack storage positions; the sample rack dispatching platform 25 is a transmission mechanism for three-dimensional XYZ motion, and is responsible for transferring and dispatching the sample rack 214, the sample rack to be tested is transmitted to the sample rack scanning area 26 through the sample rack dispatching platform 25, patient information of each sample container in the sample rack is scanned through a rotating mechanism and a bar code scanner in the sample rack scanning area 26, and then test items of biological samples are acquired from the laboratory LIS system through a network. After the barcode scanning of the sample rack 214 to be tested is completed, the sample rack is transported to the test track 213 or the transmission track 211 arranged to the host computer by the sample rack dispatching platform 25. If the sample rack 214 to be tested needs to be sent to the first host for testing, the sample rack 214 to be tested is transported to the testing track 213 behind the first host; if the sample rack 214 to be tested needs to be sent to the second host for testing, the sample rack 214 to be tested will be transported to the transfer rail 211 behind the first host and enter the test rail 213 of the second host through the first transfer rail 211. When the sample rack 214 to be tested reaches the sample suction position of the host, the periodic test control module generates a periodic action task flow after obtaining the item to be tested, and the periodic test control module executes the test flow of the biological sample according to the periodic sequence. After the sample rack has completed testing, it will be transported to the recovery track 212 and then returned to the location previously located in the sample rack storage area 23 by the sample rack dispatch platform 25. The sample injection unit is provided with two interfaces for being connected with an external laboratory assembly line in parallel, and the large assembly line inlet 27 is used for receiving a biological sample to be detected fed by the external assembly line; the large pipeline outlet 28 is used for returning biological samples, which have been tested online by the module, to the external laboratory pipeline.
It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations and modifications of the present invention will be apparent to those of ordinary skill in the art in light of the foregoing description. It is not necessary here nor is it exhaustive of all embodiments. While still being apparent from variations or modifications that may be made by those skilled in the art are within the scope of the invention.
Claims (10)
1. A high-throughput sample detection method is characterized by comprising the following steps of,
step 1: the empty reaction cups are sequentially arranged in the cup arranging assembly, and the empty cup grippers grasp the empty cup I from the cup arranging assembly and are placed in the placing holes I of the reaction cup transmission line; the empty cup gripper starts t 0 After seconds, the empty cup gripper grabs the empty cup II from the cup arranging assembly and places the empty cup II on a placement Kong Erzhong of a reaction cup transmission line;
step 2: a first sample needle aspirates a sample and doses it into the first empty cup; the first sample needle is started to be t 0 After seconds, a second sample needle sucks a sample and quantitatively distributes the sample into the second empty cup;
step 3: the second reaction cup gripper grabs the first reaction cup in the first placing hole and places the first reaction cup in the first incubation plate for treatment; the second reaction cup gripper starts t 0 After seconds, the first reaction cup gripper grabs a second reaction cup in the second placement hole and places the second reaction cup in a second incubation plate for treatment;
step 4: the first reaction cup gripper is used for placing the processed sample in the first incubation tray into a first test module for testing, and executing a cup losing action after the testing is completed; the first reaction cup gripper starts t 0 After seconds, a third reaction cup gripper places the processed sample in the second incubation plate in a second test module for testing; the first test module tests to complete t 0 After seconds, the second testing module completes testing and executes the cup losing action;
step 5: repeating the steps 1-4; wherein the detection period of each sample is T, T 0 ＝0.5T。
2. The method of high throughput sample detection according to claim 1, wherein,
in the step 3, the sample is sequentially subjected to intermediate reagent treatment and starting reagent treatment after incubation treatment;
a second reaction cup gripper grabs a first reaction cup in the first incubation tray to a first intermediate reagent needle position, distributes intermediate reagents, mixes the intermediate reagents uniformly and then returns the intermediate reagents to the first incubation tray; after the intermediate reagent treatment is finished, the first reaction cup is grabbed by the first reaction cup grab to the first starting reagent needle position, and the sample treatment is finished after the starting reagent is distributed and uniformly mixed;
the second reaction cup gripper starts t 0 After seconds, the third reaction cup gripper grabs a second reaction cup in the second incubation tray to a second intermediate reagent needle position, and the intermediate reagent is distributed, mixed uniformly and then returned to the second incubation tray; after the intermediate reagent treatment is finished, the third reaction cup is grabbed by the grabbing hand to the position of the second starting reagent needle, and the sample treatment is finished after the starting reagent is distributed and uniformly mixed.
3. The high throughput sample detection method of claim 2, wherein: sample detection period is T+t 1 At time t 0 ＝0.5T+t 1 。
4. A high throughput sample detection system, characterized in that it is detected by the detection method according to any one of claims 1 to 3; the detection system comprises a control system and at least one group of detection devices, wherein the control system is connected with and controls the operation of the detection devices, each detection device comprises,
the reaction cup supply module comprises the cup arranging assembly and the reaction cup transmission line and is used for bearing the empty reaction cup;
a sample supply module comprising a sample transfer assembly and a sample needle assembly, the sample needle assembly comprising the first and second sample needles driven by a sample needle robotic arm for sampling and sample dispensing, respectively;
a sample processing module comprising an incubation assembly and a reagent supply assembly that provides an intermediate reagent and an initiation reagent for sample processing;
the detection module is used for detecting the samples processed by the sample processing module;
the gripper module comprises the empty cup gripper, the first reaction cup gripper, the second reaction cup gripper and the third reaction cup gripper, and the second reaction cup gripper and the incubation assembly rotate around the same rotating shaft; the gripper module is used for grabbing the reaction cup to conduct sample supply, sample processing and detection.
5. The high throughput sample detection system of claim 4, wherein: the sample transmission assembly comprises a test track, a transmission track and a recovery track which are arranged in parallel; wherein the conveying direction of the test track and the conveying track is the same, and the conveying direction of the recovery track and the test track is opposite; the transmission track is used for transmitting the sample rack to other detection devices in the detection system; the recovery track is used for recovering the sample rack in the detection system; the first sample needle and the second sample needle are driven by the sample needle mechanical arm connected with the first sample needle and the second sample needle to conduct circular motion respectively, and the paths of the circular motion intersect at the sampling point of the test track.
6. The high throughput sample detection system of claim 4, wherein: the reagent supply assembly comprises a reagent bottle carrying platform and a loading unit; the reagent bottle carrier comprises at least two groups of reagent bottle tracks which are concentrically arranged, and the reagent bottle tracks are used for placing reagent bottles; the loading unit conveys the reagent bottles to the reagent bottle carrying platform through the loading mechanical arm, and the loading unit can rotate and is movably connected with the side wall of the detection device.
7. The high throughput sample detection system of claim 6, wherein: a first intermediate reagent needle, a second intermediate reagent needle, a first priming reagent needle, a second priming reagent needle, and both the first sample needle and the second sample needle are driven past the reagent bottle track.
8. The high throughput sample detection system of claim 7, wherein: the first reaction cup gripper, the second reaction cup gripper and the third reaction cup gripper are respectively provided with an eccentric wheel stirring motor; the first starting reagent needle and the second starting reagent needle are internally provided with reagent temperature control mechanisms.
9. The high throughput sample detection system of claim 4, wherein: the incubation assembly includes the first incubation plate and a second incubation plate; the first incubation tray and the second incubation tray coaxially rotate and are respectively connected with an incubation tray driving part, and the first incubation tray and the second incubation tray are respectively connected with an incubation temperature control mechanism.
10. The high throughput sample detection system of claim 4, wherein: the control system comprises a period test control module which controls the detection interval time t of the detection device 0 The method comprises the steps of carrying out a first treatment on the surface of the The control system is connected with a display screen of the detection device to output control information.
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