CN116747277A - 一种用于改善围绝经期综合症的组合物及其制备方法 - Google Patents
一种用于改善围绝经期综合症的组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于改善围绝经期综合症的组合物及其制备方法，以重量比计，所述的组合物包括：酸枣仁10～25份、茯苓10～25份、山药10～25份、枸杞子5～15份、黄精5～15份、桑椹5～15份、覆盆子5～15份、丹凤牡丹花1～10份、重瓣红玫瑰1～10份、甘草1～5份、蛇麻草1～5份、松花粉2～8份。本发明提供的一种改善围绝经期综合症的组合物，主要功效是滋肾填精，育阴潜阳，调节阴阳平衡，调摄脏腑失常，改善卵巢微循环，改善烦躁心悸、潮热、焦虑抑郁、失眠健忘、尿频急等围绝经期女性诸多症状。动物实验研究表明该组合物能够调节体内紊乱的激素水平，缓解性器官萎缩，具有改善女性围绝经期各种证候及调节激素水平的功效，无毒副作用。
Description
技术领域
本发明涉及中药技术领域，具体涉及一种用于改善围绝经期综合症生物组合物及其制备方法。
背景技术
围绝经期是女性从育龄期进入老年期必须经历的阶段，是妇女从生殖功能旺盛的状态过渡到无生殖功能的年龄阶段，即从卵巢功能开始衰退直至最后一次月经后的1年，也就是绝经过渡期加绝经后1年。现代医学认为围绝经期女性的生理特点以月经变化为主，有生殖器官的萎缩性改变，同时伴有神经精神症状、泌尿系统、心血管系统、第二性征及骨骼的变化。围绝经期妇女约1/3能通过神经内分泌的自我调节达到新的平衡而无自觉症状，2/3妇女则出现性激素减少所致一系列的症状，如月经紊乱、潮热、眩晕、头痛、耳鸣、心悸、失眠、腰背酸楚、面浮肢肿、烦躁易怒、焦虑不安、抑郁、夜尿频多、尿失禁等，称为围绝经期综合征，其中40％左右影响到工作和正常生活，严重危害中老年妇女身心健康。随着我国人口结构不断老龄化及社会竞争日益激烈、不良的工作环境、精神因素等的影响，该病出现发病年龄提早、发病率上升的趋势，已越来越被社会所重视。
围绝经期综合征是由于卵巢功能衰退，雌激素水平下降而出现一系列自主神经系统紊乱为主的症状和体征，属于中医妇科“绝经前后诸证”范畴。围绝经期妇女以肾虚为本，因为肾为天癸之源、冲任之本、气血之根。妇女进入围绝经期，肾气渐衰，任虚冲少，天癸将竭，阴阳失衡，气血不调，最终导致自然绝经，生殖器官开始萎缩，丧失生育能力，机体功能也逐渐衰退。《素问·上古天真论》云：“七七任脉虚，太冲脉衰少，天癸竭，地道不通，故形状而无子也”。肾藏元阴元阳，“五脏之阴气非此不能滋，五脏之阳气非此不能发”，故肾阴阳失调常累及心、肝、脾等其他诸脏，出现一系列神经、心血管、运动及泌尿生殖系统症状。如围绝经期妇女肾精虚，肾气亏损，则膀胱气化不利，不能固摄尿液而出现尿频急等泌尿生殖系统症状。综上，围绝经期综合征发生有关之脏，以肾虚为主，累及心、肝、脾功能失常，故治疗应标本兼治，以补肾填精为本，调肝养血为要，同进兼以养心健脾疏肝。
中国传统医学认为肾虚为围绝经期综合征发病的根本病因，多以补肾药物治疗；现代医学认为卵巢功能衰退，雌激素分泌减少是其核心病机和病理基础，主要采取激素替代疗法，但此法易导致雌激素依赖性恶性肿瘤、心脏损害、中风等发病率增高等不良反应而使用受限。而中药治疗围绝经期综合征既可以缓解临床症状，又不会增加恶性肿瘤的风险，因而得到广泛认可。现代药理研究及临床实践证实，许多补肾中药具有雌激素样作用，可以调节内分泌，调节丘脑-垂体-卵巢轴的功能，进而改善围绝经期综合征症状。因此，选用具有滋补肝肾、养心安神、补益脾胃功效的药食同源品，以补肾兼顾心、肝、脾，调摄脏腑失常，促进阴阳平衡，调节月经失调功能的组合物，安全性高，无毒副作用，携带与食用方便，可明显改善围绝经期综合征的症状，使广大女性平稳的度过围绝经期。
发明内容
本发明的目的在于弥补现有技术的不足，提供一种中药组合物，以重量比计，所述组合物包括：酸枣仁1～40份、茯苓1～40份、山药1～40份、枸杞子1～30份、黄精1～30份、桑椹1～30份、覆盆子1～30份、丹凤牡丹花1～20份、重瓣红玫瑰1～20份、甘草1～10份、蛇麻草1～10份、松花粉1～10份。本发明的组合物可以直接研磨成粉，也可以是经过本领域常规手段制得的提取物等。本发明组合物中使用的原料也可以以直接研磨成粉、提取物、或者其它加工形态的方式使用。
优选地，所述组合物包括：酸枣仁10～30份、茯苓10～30份、山药10～30份、枸杞子5～20份、黄精5～20份、桑椹1～15份、覆盆子5～20份、丹凤牡丹花1～10份、重瓣红玫瑰1～10份、甘草1～5份、蛇麻草1～5份、松花粉2～10份。
优选地，所述组合物包括：酸枣仁10～25份、茯苓10～25份、山药10～25份、枸杞子5～15份、黄精5～15份、桑椹5～15份、覆盆子5～15份、丹凤牡丹花1～10份、重瓣红玫瑰1～10份、甘草1～5份、蛇麻草1～5份、松花粉5～10份。
更优选地，所述组合物包括：酸枣仁15～20份、茯苓15～20份、山药15～20份、枸杞子10～15份、黄精10～15份、桑椹10～15份、覆盆子10～15份、丹凤牡丹花5～10份、重瓣红玫瑰5～10份、甘草1～3份、蛇麻草1～3份、松花粉5～10份。
最优选地，所述组合物包括：酸枣仁20份、茯苓20份、山药20份、枸杞子12份、黄精12份、桑椹12份、覆盆子12份、丹凤牡丹花6份、重瓣红玫瑰6份、甘草3份、蛇麻草3份、松花粉5份。
本发明还提出了一种前述任一组合物在用于改善围绝经期综合症的药品、保健品、食品中的应用。例如可以用于调节体内紊乱的激素水平和/或缓解性器官(子宫)萎缩等。
本发明的的组合物能用于制备包括滋补肝肾、调节内分泌、改善卵巢微循环、抗衰老等的药品、保健品、食品。
本发明还提出了前述任一组合物在制备包括烦躁心悸、潮热、失眠健忘、月经紊乱、尿频急等围绝经期女性症状中的药品、保健品、食品中的应用。
具体地，所述用于，可以是包括治疗或预防在内的一切有益于改善患者相应症状的方式。
本发明还提出了一种组合物，该组合物由前述任一组合物与药品、保健品、食品上可接受的辅料或添加剂制得。
具体地，该组合物选自汤剂、颗粒剂、胶囊剂、片剂、口服液、丸剂、软胶囊、滴丸、酊剂、糖浆剂、栓剂、凝胶剂、喷雾剂、注射剂。
本发明还提出了一种前述任一组合物的制备方法，所述制备方法为：
取酸枣仁、茯苓、山药、枸杞子、黄精、桑椹、覆盆子、丹凤牡丹花、重瓣红玫瑰、甘草药材加入8～12倍水回流提取，提取液过滤，滤液浓缩至相对密度1.10～1.15，离心滤过，干燥；取蛇麻草药材加入8～12倍水回流提取，提取液过滤，滤液浓缩至相对密度1.05～1.10，浓缩后的滤液干燥后和所述浸膏粉以及松花粉混合。优选地，所述组合物的制备方法包括：
取酸枣仁、茯苓、山药、枸杞子、黄精、桑椹、覆盆子、丹凤牡丹花、重瓣红玫瑰、甘草药材加入水回流提取2次，每次1小时，第一次加入12倍水，第二次加入10倍水，合并提取液，过滤，滤液浓缩至与药材比为1:1(相对密度1.10～1.15，60℃)，离心滤过，混合液喷雾干燥，得浸膏粉①；
取蛇麻草药材加入8～12倍水回流提取，提取液过滤，滤液浓缩至相对密度1.05～1.10，离心滤过，滤液喷雾干燥；
优选地，取蛇麻草药材加入水回流提取2次，每次1小时，第一次加入12倍水，第二次加入10倍水，合并提取液，过滤，滤液浓缩至与药材比为1:1(相对密度1.05～1.10，60℃)，滤液喷雾干燥，得浸膏粉②；
前述干燥后所得浸膏粉①、浸膏粉②与松花粉可根据需要进行粉碎，混合。
本发明还提出了一种中药颗粒剂的制备方法，该制备方法包括：取酸枣仁20份、茯苓20份、山药20份、枸杞子12份、黄精12份、桑椹12份、覆盆子12份、丹凤牡丹花6份、重瓣红玫瑰6份、甘草3份，加入水提取2次，每次1小时，第一次加入12倍水，第二次加入10倍水，合并提取液，过滤，滤液浓缩至与药材比为1:1(相对密度1.10～1.15，60℃)，离心滤过，滤液加入5％～15％，麦芽糊精，混合均匀，喷雾干燥，得浸膏粉①。
取蛇麻草3份，加入水提取2次，每次1小时，第一次加入12倍水，第二次加入10倍水，合并提取液，过滤，相对密度1.10～1.15，60℃，离心滤过，滤液喷雾干燥，得浸膏粉②。将得到的浸膏粉①、浸膏粉②和松花粉5份粉碎、混合均匀，即得中间体组合物，加入针叶樱桃果粉、麦芽糊精和甜菊糖苷，混匀即得。
本发明提出了一种中药组合物，并给出了制备组合物的活性提取物中间体组合物的制备方法。利用本发明提取的方法得到的组合物，本发明提供的一种改善围绝经期综合症的组合物，主要功效是滋肾填精，育阴潜阳，调节阴阳平衡，调摄脏腑失常，改善卵巢微循环，延缓衰老，对围绝经期综合征患者特别是肝肾阴虚型围绝经期综合征患者有明显疗效，能改善烦躁心悸、潮热、焦虑抑郁、失眠健忘、尿频急等围绝经期女性诸多症状。具有改善女性围绝经期各种证候及调节激素水平的功效，无毒副作用。
具体实施方式
如前所述，本发明旨在提供一种中药组合物及其制备方法和应用。以下将结合实验例的内容进行具体描述。
特别需要指出的是，针对本发明所做出的类似的替换和改动对本领域技术人员来说是显而易见的，它们都被视为包括在本发明。相关人员明显能在不脱离本发明内容、精神和范围内对本文所述的方法和应用进行改动或适当变更与组合，来实现和应用本发明技术。显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。以下是本发明中药组合物的原料药：
酸枣仁：本品为鼠李科植物酸枣Ziziphus jujuba Mill.var.spinosa(Bunge)Huex H.F.Chou的干燥成熟种子。秋末冬初采收成熟果实，除去果肉和核壳，收集种子，晒干。茯苓：本品为多孔菌科真菌茯苓Poria cocos(Schw.)Wolf的干燥菌核。山药：本品为薯蓣科植物薯蓣Dioscorea opposita Thunb.的干燥根茎。枸杞子：本品为茄科植物宁夏枸杞Lycium barbarum L.的干燥成熟果实。黄精：本品为百合科植物滇黄精Polygonatumkingianum Coll.et Hemsl.、黄精Polygonatum sibiricum Red.或多花黄精Polygonatumcyrtonema Hua的干燥根茎。桑椹：本品为桑科植物桑Morus alba L.的干燥果穗。覆盆子：本品为蔷薇科植物华东覆盆子Rubus chingii Hu的干燥果实。丹凤牡丹花为新食品原料，为芍药科植物丹凤牡丹的干燥花，具有一定的药用价值。重瓣红玫瑰：本品为蔷薇科植物玫瑰Rosa rugosa Thunb.的干燥花蕾。甘草：本品为豆科植物甘草Glycyrrhiza uralensisFisch.、胀果甘草Glycyrrhiza inflata Bat.或光果甘草Glycyrrhiza glabra L.的干燥根和根茎。蛇麻草：本品为桑科葎草属植物啤酒花Humulus lupulus L.，以未成熟的绿色果穗入药，果穗呈绿色而略带黄色时摘下，晒干，或烘干。松花粉：本品为松科植物马尾松Pinus massoniana Lamb.、油松Pinus tabulieformis Carr.或同属数种植物的干燥花粉。
本发明如未注明具体条件者，均按照常规条件或制造商建议的条件进行，所用原料药或辅料，以及所用试剂或仪器未注明生产厂商者，均为可以通过市购获得的常规产品。
实施例1中药复方颗粒
组方：酸枣仁20份、茯苓20份、山药20份、枸杞子12份、黄精12份、桑椹12份、覆盆子12份、丹凤牡丹花6份、重瓣红玫瑰6份、甘草3份、蛇麻草3份、松花粉5份。
该中药组合物颗粒剂的制备方法：
取酸枣仁、茯苓、山药、枸杞子、黄精、桑椹、覆盆子、丹凤牡丹花、重瓣红玫瑰、甘草药材加入8～12倍水回流提取，提取2次，每次1小时，第一次加入12倍水，第二次加入10倍水，合并提取液，过滤，滤液浓缩至与药材比为1:1(相对密度1.10～1.15，60℃)，离心过滤，滤液浓缩至相对密度1.10～1.15，离心滤过，加入麦芽糊精5％～15％，混合均匀，喷雾干燥，得浸膏粉①；
取蛇麻草药材加入8～12倍水回流提取，提取液过滤，滤液浓缩至相对密度1.05～1.10，离心滤过，滤液喷雾干燥。药材，加入水回流提取2次，每次1小时，第一次加入12倍水，第二次加入10倍水，合并提取液，过滤，滤液浓缩至相对密度1.05～1.10，离心滤过，滤液喷雾干燥，得浸膏粉②；
将上述获得的浸膏粉①、浸膏粉②和松花粉粉碎、混合均匀，得到中药组合物，加入针叶樱桃果粉、麦芽糊精和甜菊糖苷，利用干法制粒获得颗粒。
实施例2中药复方胶囊
组方：酸枣仁10份、茯苓20份、山药15份、枸杞子15份、黄精10份、桑椹5份、覆盆子15份、丹凤牡丹花8份、重瓣红玫瑰2份、甘草3份、蛇麻草3份、松花粉7份。
该中药组合物胶囊剂的制备方法：
取酸枣仁、茯苓、山药、枸杞子、黄精、桑椹、覆盆子、丹凤牡丹花、重瓣红玫瑰、甘草药材加入8～12倍水回流提取，提取2次，每次1小时，第一次加入12倍水，第二次加入10倍水，合并提取液，过滤，滤液浓缩至与药材比为1:1(相对密度1.10～1.15，60℃)，离心过滤，滤液浓缩至相对密度1.10～1.15，离心滤过，加入麦芽糊精5％～15％，混合均匀，喷雾干燥，得浸膏粉①。
取蛇麻草药材加入8～12倍水回流提取，提取液过滤，滤液浓缩至相对密度1.05～1.10，离心滤过，滤液喷雾干燥。药材，加入水回流提取2次，每次1小时，第一次加入12倍水，第二次加入10倍水，合并提取液，过滤，滤液浓缩至相对密度1.05～1.10，离心滤过，滤液喷雾干燥，得浸膏粉②，
将上述获得的浸膏粉①、浸膏粉②和松花粉粉碎、混合均匀，得到中药组合物，加入一定的辅料，湿法制粒，制成胶囊。
实施例3中药复方片剂
组方：酸枣仁20份、茯苓25份、山药20份、枸杞子10份、黄精5份、桑椹5份、覆盆子15份、丹凤牡丹花5份、重瓣红玫瑰5份、甘草2份、蛇麻草2份、松花粉3份。
该中药组合物片剂的制备方法：
取酸枣仁、茯苓、山药、枸杞子、黄精、桑椹、覆盆子、丹凤牡丹花、重瓣红玫瑰、甘草药材加入8～12倍水回流提取，提取2次，每次1小时，第一次加入12倍水，第二次加入10倍水，合并提取液，过滤，滤液浓缩至与药材比为1:1(相对密度1.10～1.15，60℃)，离心过滤，滤液浓缩至相对密度1.10～1.15，离心滤过，加入麦芽糊精5％～15％，混合均匀，喷雾干燥，得浸膏粉①。
取蛇麻草药材加入8～12倍水回流提取，提取液过滤，滤液浓缩至相对密度1.05～1.10，离心滤过，滤液喷雾干燥。药材，加入水回流提取2次，每次1小时，第一次加入12倍水，第二次加入10倍水，合并提取液，过滤，滤液浓缩至相对密度1.05～1.10，离心滤过，滤液喷雾干燥，得浸膏粉②，
将上述获得的浸膏粉①、浸膏粉②和松花粉粉碎、混合均匀，得到中药组合物，加入麦芽糊精、微晶纤维素等辅料，制成片剂。
实施例4本发明组合物对围绝经期去势大鼠体重与子宫指数变化、血清激素E2、FSH、LH含量的影响
1材料与方法
1.1材料
1.1.1实验动物
SPF级别大鼠，雌性36只，体重220g±20，许可证号SCXK(苏)2019-0001，由南通大学实验动物中心提供。实验期间同一室内笼养，12h光照，12h黑暗的条件下，自由饮水，摄食饲料。室温18～22℃。
1.1.2实验药物
受试药物：实施例1中制备的中药组合物给药的低、中、高剂量分别为0.18g/kg(生药量0.41g/kg)、0.36g/kg(生药量0.82g/kg)、0.72g/kg(生药量1.64g/kg)(各给药体积10mL/kg)，配制方法：用蒸馏水溶解，分别配置成浓度为0.18g/mL、0.36/mL、0.72g/mL，备用。阳性药物组：戊酸雌二醇片给药剂量为0.2mg/kg。
1.2实验方法
1.2.1造模与给药：SPF级大鼠，雌性，按体重随机分为6组，分别为正常对照组、模型对照组、阳性对照组(戊酸雌二醇0.2mg/kg)、中药组合物低剂量组(0.18g/kg)、中药组合物中剂量组(0.36g/kg)、中药组合物高剂量组(0.72g/kg)，每组6只。除正常对照组外，其余各组大鼠在3.5％的水合氯醛溶液10ml/kg腹腔注射麻醉下，背部肋下切开皮肤、肌肉，暴露腹腔，找出双侧卵巢，均切除双侧卵巢，缝合。手术后前三天每天肌注一定量青霉素，防止感染死亡。造模成功后，除正常对照组及模型对照组按体重灌胃给予容积为1mL/100g蒸馏水，各给药组分别灌胃给予相应药物，灌胃容积为1mL/100g体重，每日一次，连续1个月。实验结束后麻醉大鼠并取血，分离血清，采用试剂盒检测激素含量；分离子宫称重、计算子宫指数。
1.2.2指标测定
①血清性激素指标：给药两个月后眼眶取血，测定血清促黄体生成素(LH)、促卵泡生成素(FSH)、雌二醇(E2)水平。②脏器指数：处死大鼠后，剖开腹腔，取子宫，称量湿重，计算子宫指数。③统计分析：所有数据结果均采用均数±标准差表示，组间做两样本均数比较的t检验，以P<0.05为差异有统计学意义。
2实验结果
表1各组大鼠子宫重量和子宫指数变化(±s，n＝6)
注：与正常对照组比a)p＜0.05；与模型对照组比b)p＜0.05；与阳性组比c)p＜0.05。
由表1显示所知，与正常对照组比较，模型对照组、阳性药物组、实验低、中、高剂量组去卵巢后大鼠子宫重量以及子宫指数明显降低，其中模型对照组去卵巢后大鼠子宫重量以及子宫指数最低；与模型对照组相比，阳性药物组、实验组低、中、高剂量组大鼠子宫重量和系数均明显增加；其中实验高剂量组大鼠子宫重量和系数甚至高于阳性对照组。
表2各组大鼠血清激素含量变化(±s，n＝6)
注：与正常对照组比a)p＜0.05；与模型对照组比b)p＜0.05；与阳性组比c)p＜0.05。
结果如表2所示：与正常对照组比较，模型对照组大鼠血清E2水平明显降低，LH、FSH水平明显升高，这表明大鼠造模成功。与模型对照组相比，实施例1的药物组合物低、中、高剂量(0.18g/kg、0.36g/kg、0.72g/kg)均能显著提高模型大鼠血清E2水平，可降低模型大鼠LH、FSH水平。
这一研究显示，该实施例的药物组合物能升高围绝经期经典模型动物的雌激素水平，调节体内紊乱的激素水平，缓解性器官萎缩，与模型对照组相比具有显著性差异，这表明此药物组合物针对围绝经期大鼠模型具有一定的改善作用，可开发用于治疗围绝经期综合症的新适应症。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (10)
1.一种用于改善围绝经期综合症的组合物，其特征在于，以重量比计，所述中药组合物包括：
酸枣仁1～40份、茯苓1～40份、山药1～40份、枸杞子1～30份、黄精1～30份、桑椹1～30份、覆盆子1～30份、丹凤牡丹花1～20份、重瓣红玫瑰1～20份、甘草1～10份、蛇麻草1～10份、松花粉1～10份。
2.根据权利要求1所述的组合物，其特征在于，所述中药组合物包括：
酸枣仁10～25份、茯苓10～25份、山药10～25份、枸杞子10～15份、黄精5～15份、桑椹5～15份、覆盆子5～15份、丹凤牡丹花1～10份、重瓣红玫瑰1～10份、甘草1～5份、蛇麻草1～5份、松花粉5～10份。
3.根据权利要求1所述的组合物，其特征在于，所述中药组合物包括：
酸枣仁15～20份、茯苓15～20份、山药15～20份、枸杞子10～15份、黄精10～15份、桑椹10～15份、覆盆子10～15份、丹凤牡丹花5～10份、重瓣红玫瑰5～10份、甘草1～3份、蛇麻草1～3份、松花粉5～10份。
4.根据权利要求1所述的组合物，其特征在于，所述中药组合物包括：
酸枣仁20份、茯苓20份、山药20份、枸杞子12份、黄精12份、桑椹12份、覆盆子12份、丹凤牡丹花6份、重瓣红玫瑰6份、甘草3份、蛇麻草3份、松花粉5份。
5.权利要求1-4任一项所述的组合物在制备改善围绝经期综合症的药物、保健品或食品中的应用。
6.权利要求1-4任一项所述的组合物在制备调节体内紊乱的激素水平、缓解性器官萎缩的药物、保健品或食品中的应用。
7.一种药物、保健品或食品，其特征在于，包括权利要求1-4任一所述的组合物与可接受的辅料或添加剂。
8.根据权利要求7所述的药物、保健品或食品，其特征在于，该药物、保健品或食品选自汤剂、颗粒剂、胶囊剂、片剂、丸剂、口服液、酊剂、糖浆剂、栓剂、凝胶剂、喷雾剂、注射剂。
9.一种如权利要求1-4任一所述的组合物的制备方法，其特征在于，所述组合物制备方法包括：
取酸枣仁、茯苓、山药、枸杞子、黄精、桑椹、覆盆子、丹凤牡丹花、重瓣红玫瑰、甘草药材加入8～12倍水回流提取，提取液过滤，滤液浓缩、干燥得浸膏粉；取蛇麻草药材加入8～12倍水回流提取，提取液过滤，滤液浓缩至相对密度1.05～1.10，浓缩后的滤液干燥后和所述浸膏粉以及松花粉混合。
10.一种如权利要求7或8所述的药物、保健品或食品的制备方法，其特征在于，所述药物、保健品或食品选自颗粒剂，其制备方法包括：取酸枣仁、茯苓、山药、枸杞子、黄精、桑椹、覆盆子、丹凤牡丹花、重瓣红玫瑰、甘草药材加入水回流提取2次，每次1小时，第一次加入12倍水，第二次加入10倍水，合并提取液，过滤，滤液浓缩至相对密度1.10～1.15，离心滤过，加入麦芽糊精5％～15％，喷雾干燥，得浸膏粉①；取蛇麻草药材加入8～12倍水回流提取，提取液过滤，滤液浓缩至相对密度1.05～1.10，离心滤过，浓缩后的滤液喷雾干燥，得浸膏粉②；将得到的浸膏粉①、浸膏粉②和松花粉混合均匀，即得中间体组合物，加入针叶樱桃果粉、麦芽糊精和甜菊糖苷，混匀制粒。
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