CN116744957A - 新类肽及其在预防或治疗慢性疼痛中的用途 - Google Patents

新类肽及其在预防或治疗慢性疼痛中的用途 Download PDF

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Publication number
CN116744957A
CN116744957A CN202180068718.2A CN202180068718A CN116744957A CN 116744957 A CN116744957 A CN 116744957A CN 202180068718 A CN202180068718 A CN 202180068718A CN 116744957 A CN116744957 A CN 116744957A
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CN
China
Prior art keywords
peptoid
independently
trip8b
mice
peptoids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180068718.2A
Other languages
English (en)
Chinese (zh)
Inventor
杰罗姆·巴斯罗莱斯
埃曼努埃尔·博里内特
克劳德·泰勒弗米尔
奥利维尔·罗伊
莱昂内尔·纳顿
优素福·艾苏尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Singer Makremont Public University
Centre National de la Recherche Scientifique
Institut National de la Santé et de la Recherche Médicale
University of Montpellier
Université Clermont Auvergne
Original Assignee
Singer Makremont Public University
Centre National de la Recherche Scientifique
Institut National de la Santé et de la Recherche Médicale
University of Montpellier
Université Clermont Auvergne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Singer Makremont Public University, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, University of Montpellier, Université Clermont Auvergne filed Critical Singer Makremont Public University
Publication of CN116744957A publication Critical patent/CN116744957A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN202180068718.2A 2020-10-06 2021-09-30 新类肽及其在预防或治疗慢性疼痛中的用途 Pending CN116744957A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FRFR2010186 2020-10-06
FR2010186A FR3114739B1 (fr) 2020-10-06 2020-10-06 Nouveaux peptoides et leur utilisation dans la prevention ou le traitement de la douleur chronique
PCT/FR2021/051694 WO2022074313A1 (fr) 2020-10-06 2021-09-30 Nouveaux peptoides et leur utilisation dans la prevention ou le traitement de la douleur chronique

Publications (1)

Publication Number Publication Date
CN116744957A true CN116744957A (zh) 2023-09-12

Family

ID=74553909

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180068718.2A Pending CN116744957A (zh) 2020-10-06 2021-09-30 新类肽及其在预防或治疗慢性疼痛中的用途

Country Status (8)

Country Link
US (1) US20230374067A1 (enExample)
EP (1) EP4225295B1 (enExample)
JP (1) JP7853288B2 (enExample)
CN (1) CN116744957A (enExample)
CA (1) CA3194875A1 (enExample)
ES (1) ES3005857T3 (enExample)
FR (1) FR3114739B1 (enExample)
WO (1) WO2022074313A1 (enExample)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1498104A (zh) * 2001-03-21 2004-05-19 ������ҩ�����޹�˾ 肽类化合物用于治疗异常性疼痛或其他不同类慢性痛或幻痛的新应用
KR20080038408A (ko) * 2005-08-18 2008-05-06 쉬바르츠파르마에이지 근육통 치료를 위한 펩티드 화합물의 신규한 용도
EP2289886A1 (en) * 2009-08-31 2011-03-02 Institut d'Investigacions Biomédiques August PI I Sunyer Peptoid agonists of nerve growth factor and their use as medicaments
CN105916875A (zh) * 2013-12-23 2016-08-31 都柏林城市大学 用于慢性疼痛的多蛋白酶治疗剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7120927B2 (ja) * 2016-06-07 2022-08-17 江蘇恒瑞医薬股▲ふん▼有限公司 フェニルプロパンアミド誘導体ならびにそれらの製造方法および医薬用途
US11753432B2 (en) * 2017-01-27 2023-09-12 Academia Sinica Compound with analgesic effect for use in prevention and treatment of pain

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1498104A (zh) * 2001-03-21 2004-05-19 ������ҩ�����޹�˾ 肽类化合物用于治疗异常性疼痛或其他不同类慢性痛或幻痛的新应用
KR20080038408A (ko) * 2005-08-18 2008-05-06 쉬바르츠파르마에이지 근육통 치료를 위한 펩티드 화합물의 신규한 용도
EP2289886A1 (en) * 2009-08-31 2011-03-02 Institut d'Investigacions Biomédiques August PI I Sunyer Peptoid agonists of nerve growth factor and their use as medicaments
CN105916875A (zh) * 2013-12-23 2016-08-31 都柏林城市大学 用于慢性疼痛的多蛋白酶治疗剂

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HRUBY, V. J.，等: ""Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction"", 《PEPTIDES》, vol. 116, 20 April 2019 (2019-04-20), pages 63 - 67 *
MACHNEV, D. A.，等: ""Quantum Chemical Modelling of the Scandium Sub-Group Metal Endofullerenes"", 《CONDENSED MATTER AND INTERPHASES》, vol. 22, no. 3, 30 September 2020 (2020-09-30), pages 360 - 372 *
张瑛，等: ""TRPV1:一种同时参与慢性痛外周敏化和疼痛中枢调制的重要分子"", 《生理学报》, vol. 69, no. 5, 31 December 2017 (2017-12-31), pages 677 - 684 *

Also Published As

Publication number Publication date
US20230374067A1 (en) 2023-11-23
EP4225295B1 (fr) 2024-11-13
JP7853288B2 (ja) 2026-04-28
EP4225295C0 (fr) 2024-11-13
CA3194875A1 (fr) 2022-04-14
EP4225295A1 (fr) 2023-08-16
ES3005857T3 (en) 2025-03-17
WO2022074313A1 (fr) 2022-04-14
JP2023544842A (ja) 2023-10-25
FR3114739B1 (fr) 2022-08-26
FR3114739A1 (fr) 2022-04-08

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