CN116687985A - 一种活血散瘀和清热消炎的痔疮复合制剂 - Google Patents
一种活血散瘀和清热消炎的痔疮复合制剂 Download PDFInfo
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- CN116687985A CN116687985A CN202310918790.0A CN202310918790A CN116687985A CN 116687985 A CN116687985 A CN 116687985A CN 202310918790 A CN202310918790 A CN 202310918790A CN 116687985 A CN116687985 A CN 116687985A
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Abstract
本发明涉及一种活血散瘀和清热消炎的痔疮复合制剂,属于药物技术领域,包括熏泡剂和丸剂,所述熏泡剂包括10‑70份马齿苋、5‑40份五倍子、5‑40份朴硝、5‑30份硼砂、3‑40份明矾、1‑17份雄黄和0.5‑7份冰片;所述丸剂包括100‑500份槐角、2‑30份黄柏、3‑40份枳壳、3‑30份阿胶、5‑40份防风、4‑40份当归和3‑30份侧柏叶,所述雄黄在使用前先经过溶砷处理;本发明技术方案中,通过先熏后泡,再配合丸剂的复合治疗方案,达到治愈、养护和预防的功效,且中药的治愈手法,能够避免使用创伤性治疗手段,本发明的复合制剂治愈效果好,总有效率高达98.57%。
Description
技术领域
本发明属于药物技术领域,具体地,涉及一种活血散瘀和清热消炎的痔疮复合制剂。
背景技术
痔(俗称痔疮)是一种位于肛门部位的常见疾病,任何年龄都可发病,但随着年龄增长,发病率逐渐增高;关于痔的病因主要有两种学说。首先是静脉曲张学说,认为痔是直肠下端肛垫和肛管皮肤下的静脉丛淤血、扩张和屈曲所形成的静脉团。肛垫下移学说,认为痔原本是肛管部位正常的解剖结构,即血管垫,是齿状线及以上1.5cm的环状海绵样组织带;痔的诱发因素很多,其中便秘、长期饮酒、进食大量刺激性食物和久坐久立是主要诱因;痔按发生部位的不同分为内痔、外痔、混合痔。主要表现为便血,便血的性质可为无痛、间歇性、便后鲜血,便时滴血或手纸上带血,便秘、饮酒或进食刺激性食物后加重。
现有技术中,在针对痔疮的治疗,都需要包括针对诱发痔疮发生的其他原因的治疗,如腹泻、便秘、不良排便习惯等且痔疮的治疗不宜过度,特别是溃疡性结肠炎、克罗恩病、白塞病合并痔疮,要尽量避免使用创伤性治疗手段。
发明内容
本发明的目的在于提供一种活血散瘀和清热消炎的痔疮复合制剂,通过先熏后泡,再配合丸剂的复合治疗方案,达到治愈、养护和预防的功效,且中药的治愈手法,能够避免使用创伤性治疗手段。
本发明要解决的技术问题:在针对痔疮的治疗,都需要包括针对诱发痔疮发生的其他原因的治疗,如腹泻、便秘、不良排便习惯等且痔疮的治疗不宜过度,特别是溃疡性结肠炎、克罗恩病、白塞病合并痔疮,要尽量避免使用创伤性治疗手段。
本发明的目的可以通过以下技术方案实现:
一种活血散瘀和清热消炎的痔疮复合制剂,包括熏泡剂和丸剂,所述熏泡剂包括10-70份马齿苋、5-40份五倍子、5-40份朴硝、5-30份硼砂、3-40份明矾、1-17份雄黄和0.5-7份冰片;所述丸剂包括100-500份槐角、2-30份黄柏、3-40份枳壳、3-30份阿胶、5-40份防风、4-40份当归和3-30份侧柏叶,所述雄黄在使用前先经过溶砷处理。
进一步地,所述活血散瘀和清热消炎的痔疮复合制剂,包括熏泡剂和丸剂,所述熏泡剂包括10-40份马齿苋、5-20份五倍子、5-30份朴硝、5-20份硼砂、3-30份明矾、1-7份雄黄和0.5-3份冰片;所述丸剂包括300-500份槐角、2-20份黄柏、3-20份枳壳、3-20份阿胶、5-20份防风、4-20份当归和3-20份侧柏叶。
进一步地,所述活血散瘀和清热消炎的痔疮复合制剂,包括熏泡剂和丸剂,所述熏泡剂包括30份马齿苋、15份五倍子、15份朴硝、15份硼砂、15份明矾、5份雄黄和1份冰片;所述丸剂包括360份槐角、15份黄柏、15份枳壳、15份阿胶、15份防风、15份当归和15份侧柏叶。
进一步地,雄黄在使用前先经过溶砷处理,具体步骤为:
A1、将6.8g磷酸二氢钾加入500mL水中溶解,用0.1mol·L-1氢氧化钠溶液调节pH值至6.8,再加入10g胰蛋白酶,然后,加水至1000mL,得到溶解液;
A2、将0.083g雄黄分别加入15mL溶解液中,温度为37℃±2℃,然后,以100rpm的速度磁力搅拌,8小时后,将溶液以6000rpm离心10分钟,然后将上清液用高纯水稀释并使用0.45μm微孔滤膜过滤。
本发明中考虑到雄黄中含有砷元素,通过胰蛋白酶的溶解,实现砷元素的浸出,提升熏泡剂对皮肤的安全性。
进一步地,所述熏泡剂的制备方法为:马齿苋和五倍子加水煎30分钟。
进一步地,所述丸剂的制备方法为:槐角、黄柏、地榆、枳壳、阿胶、防风、当归和侧柏叶共为细粉,炼蜜为丸。
方中:
朴硝:味咸、苦,性寒;泻下通便,润燥软坚,清火消肿;用于实热积滞,腹满胀痛,大便燥结,肠痈肿痛;外治乳痈,痔疮肿痛。
硼砂:性味甘、咸、凉,入肺、胃经;硼砂甘凉可清热,咸可软坚,既能消痰破结,还有解毒消肿、防腐的作用。为眼科、喉科常用的要药。
明矾:味酸、涩,性寒;外用解毒杀虫,燥湿止痒;内服止血止泻,祛除风痰;外治用于湿疹,疥癣,脱肛,痔疮,聤耳流脓;内服用于久泻不止,便血,崩漏,癫痫发狂。枯矾收湿敛疮,止血化腐。用于湿疹湿疮,脱肛,痔疮,聤耳流脓,阴痒带下,鼻衄齿衄,鼻瘜肉。
雄黄:辛味,性温;解毒杀虫,燥湿祛痰,截疟;用于痈肿疔疮,蛇虫咬伤,虫积腹痛,惊痫,疟疾。
冰片:味辛、苦,微寒;归心、肝、肺经;清香宣散,具有开窍醒神,清热散毒,明目退翳的功效,主治热病高热神昏,中风痰厥惊痫,暑湿蒙蔽清窍,喉痹耳聋,口疮齿肿,疮痈疳痔,目赤肿痛,翳膜遮睛。
马齿苋:酸,寒;清热解毒,凉血止血,止痢;主治热毒血痢,痈肿疔疮,湿疹,丹毒,蛇虫咬伤,便血,痔血,崩漏下血。
五倍子:味酸、涩,性寒;敛肺降火,涩肠止泻,敛汗,止血,收湿敛疮;主治用于肺虚久咳,肺热痰嗽,久泻久痢,自汗盗汗,消渴,便血痔血,外伤出血,痈肿疮毒,皮肤湿烂。
槐角:槐角为豆科(蝶形花科)植物槐的干燥成熟果实,味苦,性寒,归肝、大肠经,具有清热泻火、凉血止血等功效。
黄柏:味苦,性寒;有清热燥湿,泻火除蒸,解毒疗疮的功效;用于湿热泻痢,黄疸尿赤,带下阴痒,热淋涩痛,脚气痿蹙,骨蒸劳热,盗汗,遗精,疮疡肿毒,湿疹湿疮。盐黄柏滋阴降火。用于阴虚火旺,盗汗骨蒸。
枳壳:味苦,归脾、胃经,能理气宽中、行滞消胀;用于胸胁气滞、胁满胀痛、食物消化不良、胀气下垂的治疗。
阿胶:阿胶味甘,性平,归肺、肝、肾经;阿胶含有丰富的胶原蛋白和氨基酸等,可以促进血液循环,增加血红蛋白含量,改善贫血等问题
防风:味辛、甘,性微温;祛风解表,胜湿止痛,止痉;用于外感表证,风疹瘙痒,风湿痹痛,破伤风症,脾虚湿盛。
当归:味甘、辛,性温;补血活血,调经止痛,润肠通便;用于血虚萎黄,眩晕心悸,月经不调,经闭痛经,虚寒腹痛,风湿痹痛,跌扑损伤,痈疽疮疡,肠燥便秘。酒当归活血通经。用于经闭痛经,风湿痹痛,跌扑损伤。
侧柏叶:味苦、涩,寒;凉血止血,化痰止咳,生发乌发;用于吐血,衄血,咯血,便血,崩漏下血,肺热咳嗽,血热脱发,须发早白。
本发明的有益效果:
本发明技术方案中,通过先熏后泡,再配合丸剂的复合治疗方案,达到治愈、养护和预防的功效,且中药的治愈手法,能够避免使用创伤性治疗手段,本发明的复合制剂治愈效果好,总有效率高达98.57%。
具体实施方式
下面将结合本发明实施例,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其它实施例,都属于本发明保护的范围。
一种活血散瘀和清热消炎的痔疮复合制剂,包括熏泡剂和丸剂,熏泡剂包括30g马齿苋、15g五倍子、15g朴硝、15g硼砂、15g明矾、5g雄黄和1g冰片;丸剂包括360g槐角、15g黄柏、15g枳壳、15g阿胶、15g防风、15g当归和15g侧柏叶。
雄黄在使用前先经过溶砷处理,具体步骤为:
A1、将6.8g磷酸二氢钾加入500mL水中溶解,用0.1mol·L-1氢氧化钠溶液调节pH值至6.8,再加入10g胰蛋白酶,然后,加水至1000mL,得到溶解液;
A2、将0.083g雄黄分别加入15mL溶解液中,温度为37℃±2℃,然后,以100rpm的速度磁力搅拌,8小时后,将溶液以6000rpm离心10分钟,然后将上清液用高纯水稀释并使用0.45μm微孔滤膜过滤。
将马齿苋30g五倍子15g加3L水煎30分钟,得到熏泡剂;
将槐角360g、黄柏15g、地榆15g、枳壳15g、阿胶15g、防风15g、当归15g和侧柏叶15g共为细粉,炼蜜为丸,得到丸剂。
以下是针对本发明做的实际测试资料:
观察资料:
为我所自2018年6月至2019年6月接诊未手术肛肠病患者280例,男160例,女120例,年龄20-70岁,平均38.8岁;病程3个月-20年,平均6.8年。其中混合痔外痔嵌顿45例,炎性外痔115例,血栓性外痔60例,肛裂60例参照参照国家中医肛肠病症疗效标准确诊;以上病例随机分为两组,治疗组140例,女47例,男48例,年龄15-75岁,其中混合痔67例,急性血栓外痔16例,肛裂10例,肛门瘙痒2例。
疗效判断标准:
痊愈:症状、体征消失,皮肤光滑,显效:症状体征减轻,痔疮面积缩小50%或重度转中度,中度转轻度;有效:症状、体征部分减轻,痔疮面积缩小于50%或痔疮面积缩小不明显,乳头型转为颗粒型,颗粒型转为单纯型;无效:症状、体征无减轻,痔疮面积无变化。总有效率=痊愈率+显效率+有效率。
方法:
马齿苋30g五倍子15g加3L水煎30分钟,先熏后泡,每次20分钟,连续坐浴7-20天,口服中药丸(槐角【九蒸】360g黄柏15g地榆15g枳壳15g阿胶15g防风15g当归15g侧柏叶15g共为细粉,炼蜜为丸,每次服6g,早晚各1次,用米油饮下对症治疗。对照组常规传统1:5000高锰酸钾坐浴,每天2次,每次20分钟,加活血、抗炎药物对症治疗。两组治疗均为7天1疗程,2个疗程结束后判断疗效,并进行统计学分析。
结果:
治疗组140例经中药熏洗加汤药口服3-7d后血栓吸收,水肿消失,疼痛缓解,痊愈85例,占60%,其中血栓性外痔35例,炎性外痔30例,肛裂15例,嵌顿痔5例。好转43例,占37%,其中血栓性外痔15例,炎性外痔20例,肛裂5例,嵌顿痔3例;无效2例,占1.4%,均为血栓性外痔不能吸收,总有效率98.57%,治疗时间3-14d,平均8d。对照组常规使用1:5000高锰酸钾坐浴,痊愈42例,好转74例,无效24例,总有效率82.85%。
2组疗效比较治疗后,治疗组总有效率为98.57%,明显高于对照组82.85%,差异有统计学意义(P<0.05)
表1 2组病人疗效比较(例,%)
P<0.05VS对照组
在说明书的描述中,参考术语“一个实施例”、“示例”、“具体示例”等的描述意指结合该实施例或示例描述的具体特征、结构、材料或者特点包含于本发明的至少一个实施例或示例中。在本说明书中,对上述术语的示意性表述不一定指的是相同的实施例或示例。而且,描述的具体特征、结构、材料或者特点可以在任何的一个或多个实施例或示例中以合适的方式结合。
以上内容仅仅是对本发明所作的举例和说明,所属本技术领域的技术人员对所描述的具体实施例做各种各样的修改或补充或采用类似的方式替代,只要不偏离发明或者超越本权利要求书所定义的范围,均应属于本发明的保护范围。
Claims (6)
1.一种活血散瘀和清热消炎的痔疮复合制剂,包括熏泡剂和丸剂,所述熏泡剂包括10-70份马齿苋、5-40份五倍子、5-40份朴硝、5-30份硼砂、3-40份明矾、1-17份雄黄和0.5-7份冰片;所述丸剂包括100-500份槐角、2-30份黄柏、3-40份枳壳、3-30份阿胶、5-40份防风、4-40份当归和3-30份侧柏叶,所述雄黄在使用前先经过溶砷处理。
2.根据权利要求1所述的一种活血散瘀和清热消炎的痔疮复合制剂,其特征在于:所述活血散瘀和清热消炎的痔疮复合制剂,包括熏泡剂和丸剂,所述熏泡剂包括10-40份马齿苋、5-20份五倍子、5-30份朴硝、5-20份硼砂、3-30份明矾、1-7份雄黄和0.5-3份冰片;所述丸剂包括300-500份槐角、2-20份黄柏、3-20份枳壳、3-20份阿胶、5-20份防风、4-20份当归和3-20份侧柏叶。
3.根据权利要求1所述的一种活血散瘀和清热消炎的痔疮复合制剂,其特征在于:所述活血散瘀和清热消炎的痔疮复合制剂,包括熏泡剂和丸剂,所述熏泡剂包括30份马齿苋、15份五倍子、15份朴硝、15份硼砂、15份明矾、5份雄黄和1份冰片;所述丸剂包括360份槐角、15份黄柏、15份枳壳、15份阿胶、15份防风、15份当归和15份侧柏叶。
4.根据权利要求1所述的一种活血散瘀和清热消炎的痔疮复合制剂,其特征在于:雄黄在使用前先经过溶砷处理,具体步骤为:
A1、将磷酸二氢钾加入水中溶解,用0.1mol·L-1氢氧化钠溶液调节pH值至6.8,再加入胰蛋白酶,然后加水至1000mL,得到溶解液;
A2、将雄黄分别加入溶解液中,温度为37℃±2℃,然后,以100rpm的速度磁力搅拌,8小时后,将溶液以6000rpm离心10分钟,然后将上清液用高纯水稀释并使用0.45μm微孔滤膜过滤。
5.根据权利要求1所述的一种活血散瘀和清热消炎的痔疮复合制剂,其特征在于:所述熏泡剂的制备方法为:马齿苋和五倍子加水煎30分钟。
6.根据权利要求1所述的一种活血散瘀和清热消炎的痔疮复合制剂,其特征在于:所述丸剂的制备方法为:槐角、黄柏、地榆、枳壳、阿胶、防风、当归和侧柏叶共为细粉,炼蜜为丸。
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