CN116649576A - Nicotine buccal product containing antibacterial and antioxidant composition and preparation method thereof - Google Patents
Nicotine buccal product containing antibacterial and antioxidant composition and preparation method thereof Download PDFInfo
- Publication number
- CN116649576A CN116649576A CN202310709145.8A CN202310709145A CN116649576A CN 116649576 A CN116649576 A CN 116649576A CN 202310709145 A CN202310709145 A CN 202310709145A CN 116649576 A CN116649576 A CN 116649576A
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- CN
- China
- Prior art keywords
- parts
- nicotine
- antibacterial
- buccal
- antioxidant composition
- Prior art date
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- Pending
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 155
- 229960002715 nicotine Drugs 0.000 title claims abstract description 129
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims abstract description 129
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 110
- 239000000203 mixture Substances 0.000 title claims abstract description 105
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 94
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 91
- 229940095523 buccal product Drugs 0.000 title claims abstract description 74
- 238000002360 preparation method Methods 0.000 title abstract description 16
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 92
- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 claims abstract description 38
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 37
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- 239000003765 sweetening agent Substances 0.000 claims abstract description 37
- 239000000945 filler Substances 0.000 claims abstract description 25
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 23
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims abstract description 22
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims abstract description 22
- 235000021283 resveratrol Nutrition 0.000 claims abstract description 22
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- DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 claims abstract description 19
- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 claims abstract description 19
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims abstract description 18
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 claims abstract description 18
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- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 claims abstract description 18
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 42
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- VAUQRLHPXWYZRZ-PPHPATTJSA-N benzoic acid 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine Chemical group OC(=O)c1ccccc1.CN1CCC[C@H]1c1cccnc1 VAUQRLHPXWYZRZ-PPHPATTJSA-N 0.000 claims description 14
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The application discloses a nicotine buccal product containing an antibacterial and antioxidant composition and a preparation method thereof, and relates to the technical field of buccal products. The buccal product comprises an antibacterial and antioxidant composition, wherein the antibacterial and antioxidant composition is a mixture of hericium erinaceus polysaccharide, procyanidine, resveratrol, ellagic acid, rosmarinic acid and hyperoside. Also comprises one or more of nicotine and/or nicotine salt, sweetener, correctant, filler, disintegrating agent, antiseptic, humectant, and distilled water. According to the application, the antibacterial and antioxidant composition is added on the basis of the existing nicotine buccal product, so that the nicotine buccal product has antibacterial and antioxidant effects while obtaining the satisfaction of nicotine, can improve the related hygiene problem of the oral cavity, and has a certain health care effect in the aspects of scavenging free radicals and inhibiting inflammation.
Description
Technical Field
The application relates to the technical field of buccal products, in particular to a nicotine buccal product containing an antibacterial and antioxidant composition and a preparation method thereof.
Background
A nicotine buccal product is a buccal product comprising nicotine and/or nicotine salts which provides a certain feeling of nicotine satisfaction to the consumer by means of buccal. In order to meet the demands of consumers on nicotine, the nicotine buccal product in the prior art usually brings bad mouthfeel such as irritation, pungency, bitterness and the like, has single taste and poor comfort, and is easy to cause stomatitis. Therefore, there is a need for a nicotine buccal product with antibacterial and antioxidant effects, which can improve the oral hygiene problem and inhibit inflammation while achieving the satisfaction of nicotine.
Disclosure of Invention
In order to solve the technical problems, the application provides a nicotine buccal product containing a bacteriostatic and antioxidant composition and a preparation method thereof. The method specifically comprises the following technical scheme:
in a first aspect, a nicotine buccal product is provided comprising an antibacterial and antioxidant composition which is a mixture of hericium erinaceus polysaccharide, procyanidins, resveratrol, ellagic acid, rosmarinic acid, hyperin.
The hericium erinaceus polysaccharide is an effective active ingredient extracted from good-quality hericium erinaceus fruit bodies, can remove active oxygen, inhibit lipid peroxidation, improve antioxidant enzyme activity, protect cell membranes and resist aging, has the functions of promoting digestion and benefiting five viscera, has good curative effects on various digestive tract diseases such as chronic gastritis, duodenal ulcer and the like, and can improve the immunity of a human body.
Procyanidine is a super natural antioxidant, and has effects of scavenging free radicals, improving vascular elasticity, improving circulatory system, improving skin smoothness, and inhibiting inflammation and allergy.
Resveratrol is a polyphenol compound with antioxidant, antiinflammatory, anticancer and cardiovascular protecting effects. Resveratrol has good effect in preventing and treating oxidative stress related to aging. Experiments prove that resveratrol is an effective scavenger of hydroxyl, superoxide and metal induction groups.
Ellagic acid can remove free radicals in human body, improve oxidation resistance of human body, reduce injury of free radicals to human body cells, maintain human health, and slow aging.
Rosmarinic acid is a natural antioxidant, has strong antioxidant activity, helps to prevent cell damage caused by free radicals, has strong anti-inflammatory activity, and has antibacterial, antiviral and antitumor activities.
Hyperin has wide distribution, and has antiinflammatory and antioxidant effects.
Further, the nicotine buccal product containing the antibacterial and antioxidant composition further comprises one or more of nicotine and/or nicotine salt, sweetener, flavoring agent, filler, disintegrating agent, preservative, humectant and distilled water.
Further, the nicotine buccal product containing the antibacterial and antioxidant composition comprises the following components in parts by weight:
6-30 parts of antibacterial and antioxidant composition, 0.3-6 parts of nicotine and/or nicotine salt, 1-10 parts of sweetener, 1-10 parts of corrigent, 20-60 parts of filler, 1-10 parts of disintegrating agent, 0.1-1 part of preservative, 1-10 parts of humectant and 20-50 parts of distilled water.
Further, the nicotine buccal product containing the antibacterial and antioxidant composition comprises the following components in parts by weight:
6-25 parts of antibacterial and antioxidant composition, 1-3 parts of nicotine and/or nicotine salt, 1-5 parts of sweetener, 1-5 parts of corrigent, 30-50 parts of filler, 5-10 parts of disintegrating agent, 0.1-0.5 part of preservative, 5-10 parts of humectant and 30-40 parts of distilled water.
Further, the antibacterial and antioxidant composition comprises, by weight, 1-4 parts of hericium erinaceus polysaccharide, 1-4 parts of procyanidine, 1-4 parts of resveratrol, 1-4 parts of ellagic acid, 1-4 parts of rosmarinic acid and 1-4 parts of hyperin.
Further, the nicotine salt is nicotine benzoate, and the sweetener is one or more selected from erythritol, xylitol and acesulfame potassium.
Further, the flavoring agent is one or more selected from peppermint essence, strawberry essence and lemon essence, and the filler is one or more selected from sodium alginate, microcrystalline cellulose sodium, acacia, guar gum, pregelatinized starch, methylcellulose and hydroxymethyl cellulose sodium.
Further, the disintegrating agent is one or more selected from citric acid, malic acid, sodium carbonate and sodium bicarbonate.
Further, the preservative is selected from one of potassium sorbate and sodium benzoate, and the humectant is glycerol.
In a second aspect, there is provided a method of preparing a nicotine buccal product comprising a bacteriostatic antioxidant composition as defined in the first aspect comprising the steps of:
s1, weighing the components according to parts by weight;
s2, slowly adding a filler, a disintegrating agent, a sweetener, a preservative and a bacteriostatic and antioxidant composition into distilled water, uniformly stirring by using a magnetic stirrer at normal temperature, wherein the rotating speed is about 230-250r/min, stirring for about 40-45min, drying at 55-60 ℃, crushing by using a crusher, and sieving by using a 50-60-mesh sieve to obtain mixed powder;
s3, uniformly mixing nicotine and/or nicotine salt, a humectant and a flavoring agent to obtain a mixed solution;
s4, adding the mixed solution obtained in the step S3 into the mixed powder obtained in the step S2, and stirring at a rotating speed of 100-150r/min for 20-30min to obtain a mixture;
s5, placing the mixture obtained in the step S4 for 12 hours, and bagging according to the specification that each bag is 0.6g, thus obtaining the nicotine buccal product containing the antibacterial and antioxidant composition.
The application provides a nicotine buccal product containing a bacteriostatic and antioxidant composition and a preparation method thereof, wherein the bacteriostatic and antioxidant composition is added on the basis of the existing nicotine buccal product, so that the nicotine buccal product has bacteriostatic and antioxidant effects while obtaining a nicotine satisfaction, can improve the relevant sanitary problems of the oral cavity, and has a certain health care effect in the aspects of scavenging free radicals and inhibiting inflammation.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present application, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 shows the DPPH inhibition rate test results of the nicotine buccal preparation of examples 1 to 5 of the present application containing the antibacterial and antioxidant composition and the nicotine buccal preparation of comparative example 1.
Detailed Description
The following description of the embodiments of the present application will be made clearly and completely, and it is apparent that the described embodiments are some, but not all, embodiments of the present application. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
It should be understood that the terms "comprises" and "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It is also to be understood that the terminology used in the description of the application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in this specification and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
It should be further understood that the term "and/or" as used in the present specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations.
In order to more fully understand the technical content of the present application, the following description and description of the technical solution of the present application will be further presented with reference to specific embodiments.
A method of preparing a nicotine buccal product comprising an antibacterial antioxidant composition comprising the steps of:
s1, weighing the components according to parts by weight;
s2, slowly adding a filler, a disintegrating agent, a sweetener, a preservative and a bacteriostatic and antioxidant composition into distilled water, uniformly stirring by a magnetic stirrer at normal temperature, stirring for 40-45min at the rotating speed of 230-250r/min, drying at 55-60 ℃, crushing by a crusher, and sieving by a 50-60-mesh sieve to obtain mixed powder;
s3, uniformly mixing nicotine and/or nicotine salt, a humectant and a flavoring agent to obtain a mixed solution;
s4, adding the mixed solution obtained in the step S3 into the mixed powder obtained in the step S2, and stirring at a rotating speed of 100-150r/min for 20-30min to obtain a mixture;
s5, placing the mixture obtained in the step S4 for 12 hours, and bagging according to the specification that each bag is 0.6g, thus obtaining the nicotine buccal product containing the antibacterial and antioxidant composition.
Example 1
A nicotine buccal product containing a bacteriostatic and antioxidant composition, which comprises the following components in parts by weight:
11 parts of antibacterial and antioxidant composition (2 parts of hericium erinaceus polysaccharide, 2 parts of procyanidine, 2 parts of resveratrol, 1 part of ellagic acid, 3 parts of rosmarinic acid and 1 part of hyperin), 3 parts of nicotine and nicotine salt (1 part of nicotine and 2 parts of nicotine benzoate), 3 parts of sweetener, 5 parts of flavoring agent, 31 parts of filler (1 part of sodium alginate, 20 parts of microcrystalline cellulose sodium and 10 parts of pregelatinized starch), 6 parts of disintegrating agent (1 part of citric acid and 5 parts of sodium bicarbonate), 0.5 part of preservative, 10 parts of humectant and 30 parts of distilled water. The sweetener is erythritol, the flavoring agent is mint essence, the preservative is potassium sorbate, and the humectant is glycerol.
A method of preparing a nicotine buccal product comprising an antibacterial antioxidant composition of example 1 comprising the steps of:
s1, weighing the components according to parts by weight;
s2, slowly adding a filler, a disintegrating agent, a sweetener, a preservative and a bacteriostatic and antioxidant composition into distilled water, uniformly stirring by using a magnetic stirrer at normal temperature, stirring for 45min at the rotating speed of 250r/min, drying at 60 ℃, crushing by using a crusher, and sieving by using a 60-mesh sieve to obtain mixed powder;
s3, uniformly mixing nicotine and/or nicotine salt, a humectant and a flavoring agent to obtain a mixed solution;
s4, adding the mixed solution obtained in the step S3 into the mixed powder obtained in the step S2, and stirring at a rotating speed of 150r/min for 30min to obtain a mixture;
s5, placing the mixture obtained in the step S4 for 12 hours, and bagging according to the specification that each bag is 0.6g, so as to obtain the nicotine buccal product containing the antibacterial and antioxidant composition in the embodiment 1.
The nicotine buccal preparation containing the antibacterial and antioxidant composition of examples 2 to 5 and comparative examples 2 to 7 and the nicotine buccal preparation of comparative example 1 were prepared in the same manner as in example 1.
Example 2
A nicotine buccal product containing a bacteriostatic and antioxidant composition, which comprises the following components in parts by weight:
7 parts of antibacterial and antioxidant composition (2 parts of hericium erinaceus polysaccharide, 1 part of procyanidine, 1 part of resveratrol, 1 part of ellagic acid, 1 part of rosmarinic acid and 1 part of hyperin), 3 parts of nicotine and nicotine salt (1 part of nicotine and 2 parts of nicotine benzoate), 3 parts of sweetener, 5 parts of flavoring agent, 37 parts of filler (1 part of sodium alginate, 26 parts of microcrystalline cellulose sodium and 10 parts of pregelatinized starch), 6 parts of disintegrating agent (1 part of citric acid and 5 parts of sodium bicarbonate), 0.5 part of preservative, 10 parts of humectant and 30 parts of distilled water. The sweetener is erythritol, the flavoring agent is mint essence, the preservative is potassium sorbate, and the humectant is glycerol.
Example 3
A nicotine buccal product containing a bacteriostatic and antioxidant composition, which comprises the following components in parts by weight:
24 parts of antibacterial and antioxidant composition (4 parts of hericium erinaceus polysaccharide, 4 parts of procyanidine, 4 parts of resveratrol, 4 parts of ellagic acid, 4 parts of rosmarinic acid and 4 parts of hyperin), 3 parts of nicotine and nicotine salt (1 part of nicotine and 2 parts of nicotine benzoate), 3 parts of sweetener, 5 parts of flavoring agent, 37 parts of filler (1 part of sodium alginate, 26 parts of microcrystalline cellulose sodium and 10 parts of pregelatinized starch), 6 parts of disintegrating agent (1 part of citric acid and 5 parts of sodium bicarbonate), 0.5 part of preservative, 10 parts of humectant and 30 parts of distilled water. The sweetener is erythritol, the flavoring agent is mint essence, the preservative is potassium sorbate, and the humectant is glycerol.
Example 4
A nicotine buccal product containing a bacteriostatic and antioxidant composition, which comprises the following components in parts by weight:
10 parts of antibacterial and antioxidant composition (3 parts of hericium erinaceus polysaccharide, 3 parts of procyanidine, 1 part of resveratrol, 1 part of ellagic acid, 1 part of rosmarinic acid and 1 part of hyperin), 3 parts of nicotine and nicotine salt (1 part of nicotine and 2 parts of nicotine benzoate), 3 parts of sweetener, 5 parts of flavoring agent, 37 parts of filler (1 part of sodium alginate, 26 parts of microcrystalline cellulose sodium and 10 parts of pregelatinized starch), 6 parts of disintegrating agent (1 part of citric acid and 5 parts of sodium bicarbonate), 0.5 part of preservative, 10 parts of humectant and 30 parts of distilled water. The sweetener is erythritol, the flavoring agent is mint essence, the preservative is potassium sorbate, and the humectant is glycerol.
Example 5
A nicotine buccal product containing a bacteriostatic and antioxidant composition, which comprises the following components in parts by weight:
6 parts of antibacterial and antioxidant composition (1 part of hericium erinaceus polysaccharide, 1 part of procyanidine, 1 part of resveratrol, 1 part of ellagic acid, 1 part of rosmarinic acid and 1 part of hyperin), 3 parts of nicotine and nicotine salt (1 part of nicotine and 2 parts of nicotine benzoate), 3 parts of sweetener, 5 parts of flavoring agent, 37 parts of filler (1 part of sodium alginate, 26 parts of microcrystalline cellulose sodium and 10 parts of pregelatinized starch), 6 parts of disintegrating agent (1 part of citric acid and 5 parts of sodium bicarbonate), 0.5 part of preservative, 10 parts of humectant and 30 parts of distilled water. The sweetener is erythritol, the flavoring agent is mint essence, the preservative is potassium sorbate, and the humectant is glycerol.
Comparative example 1
A nicotine buccal product comprises the following components in parts by weight:
3 parts of nicotine and nicotine salt (1 part of nicotine and 2 parts of nicotine benzoate), 3 parts of sweetener, 5 parts of flavoring agent, 31 parts of filler (1 part of sodium alginate, 20 parts of microcrystalline cellulose sodium and 10 parts of pregelatinized starch), 6 parts of disintegrating agent (1 part of citric acid and 5 parts of sodium bicarbonate), 0.5 part of preservative, 10 parts of humectant and 30 parts of distilled water. The sweetener is erythritol, the flavoring agent is mint essence, the preservative is potassium sorbate, and the humectant is glycerol.
Comparative example 2
A nicotine buccal product containing a bacteriostatic and antioxidant composition, which comprises the following components in parts by weight:
11 parts of antibacterial and antioxidant composition (hericium erinaceus polysaccharide 0.5 parts, procyanidine 0.5 parts, resveratrol 2 parts, ellagic acid 3 parts, rosmarinic acid 3 parts, hyperin 2 parts), nicotine and nicotine salt 3 parts (nicotine 1 part, nicotine benzoate 2 parts), sweetener 3 parts, flavoring agent 5 parts, filler 31 parts (sodium alginate 1 part, microcrystalline cellulose sodium 20 parts, pregelatinized starch 10 parts), disintegrating agent 6 parts (citric acid 1 part, sodium bicarbonate 5 parts), preservative 0.5 parts, humectant 10 parts and distilled water 30 parts. The sweetener is erythritol, the flavoring agent is mint essence, the preservative is potassium sorbate, and the humectant is glycerol.
Comparative example 3
A nicotine buccal product containing a bacteriostatic and antioxidant composition, which comprises the following components in parts by weight:
11 parts of antibacterial and antioxidant composition (2 parts of hericium erinaceus polysaccharide, 2 parts of procyanidine, 3 parts of resveratrol, 0.5 part of ellagic acid, 3 parts of rosmarinic acid and 0.5 part of hyperin), 3 parts of nicotine and nicotine salt (1 part of nicotine and 2 parts of nicotine benzoate), 3 parts of sweetener, 5 parts of flavoring agent, 31 parts of filler (1 part of sodium alginate, 20 parts of microcrystalline cellulose sodium and 10 parts of pregelatinized starch), 6 parts of disintegrating agent (1 part of citric acid and 5 parts of sodium bicarbonate), 0.5 part of preservative, 10 parts of humectant and 30 parts of distilled water. The sweetener is erythritol, the flavoring agent is mint essence, the preservative is potassium sorbate, and the humectant is glycerol.
Comparative example 4
A nicotine buccal product containing a bacteriostatic and antioxidant composition, which comprises the following components in parts by weight:
3 parts of antibacterial and antioxidant composition (hericium erinaceus polysaccharide 0.5 parts, procyanidine 0.5 parts, resveratrol 0.5 parts, ellagic acid 0.5 parts, rosmarinic acid 0.5 parts, hyperin 0.5 parts), 3 parts of nicotine and nicotine salt (nicotine 1 part, nicotine benzoate 2 parts), 3 parts of sweetener, 5 parts of flavoring agent, 31 parts of filler (sodium alginate 1 part, microcrystalline cellulose sodium 20 parts, pregelatinized starch 10 parts), 6 parts of disintegrating agent (citric acid 1 part, sodium bicarbonate 5 parts), 0.5 part of preservative, 10 parts of humectant and 30 parts of distilled water. The sweetener is erythritol, the flavoring agent is mint essence, the preservative is potassium sorbate, and the humectant is glycerol.
Comparative example 5
A nicotine buccal product containing a bacteriostatic and antioxidant composition, which comprises the following components in parts by weight:
10 parts of antibacterial and antioxidant composition (2 parts of hericium erinaceus polysaccharide, 2 parts of procyanidine, 2 parts of resveratrol, 1 part of ellagic acid, 3 parts of rosmarinic acid), 3 parts of nicotine and nicotine salt (1 part of nicotine and 2 parts of nicotine benzoate), 3 parts of sweetener, 5 parts of flavoring agent, 31 parts of filler (1 part of sodium alginate, 20 parts of microcrystalline cellulose sodium and 10 parts of pregelatinized starch), 6 parts of disintegrating agent (1 part of citric acid and 5 parts of sodium bicarbonate), 0.5 part of preservative, 10 parts of humectant and 30 parts of distilled water. The sweetener is erythritol, the flavoring agent is mint essence, the preservative is potassium sorbate, and the humectant is glycerol.
Comparative example 6
A nicotine buccal product containing a bacteriostatic and antioxidant composition, which comprises the following components in parts by weight:
9 parts of antibacterial and antioxidant composition (2 parts of hericium erinaceus polysaccharide, 2 parts of procyanidine, 2 parts of resveratrol and 3 parts of rosmarinic acid), 3 parts of nicotine and nicotine salt (1 part of nicotine and 2 parts of nicotine benzoate), 3 parts of sweetener, 5 parts of flavoring agent, 31 parts of filler (1 part of sodium alginate, 20 parts of microcrystalline cellulose sodium and 10 parts of pregelatinized starch), 6 parts of disintegrating agent (1 part of citric acid and 5 parts of sodium bicarbonate), 0.5 part of preservative, 10 parts of humectant and 30 parts of distilled water. The sweetener is erythritol, the flavoring agent is mint essence, the preservative is potassium sorbate, and the humectant is glycerol.
Comparative example 7
A nicotine buccal product containing a bacteriostatic and antioxidant composition, which comprises the following components in parts by weight:
6 parts of antibacterial and antioxidant composition (2 parts of hericium erinaceus polysaccharide, 2 parts of procyanidine and 2 parts of resveratrol), 3 parts of nicotine and nicotine salt (1 part of nicotine and 2 parts of nicotine benzoate), 3 parts of sweetener, 5 parts of flavoring agent, 31 parts of filler (1 part of sodium alginate, 20 parts of microcrystalline cellulose sodium and 10 parts of pregelatinized starch), 6 parts of disintegrating agent (1 part of citric acid and 5 parts of sodium bicarbonate), 0.5 part of preservative, 10 parts of humectant and 30 parts of distilled water. The sweetener is erythritol, the flavoring agent is mint essence, the preservative is potassium sorbate, and the humectant is glycerol.
Taste evaluation
The evaluation method comprises the steps of setting 10 sensory evaluation persons, setting an evaluation table for each person, scoring after each person experiences the nicotine buccal product by adopting a dark evaluation mode, removing a highest score and a lowest score, and taking an average value. Wherein, the irritation means: the nicotine buccal product has uncomfortable feeling to sense organs including mouth, throat and produced; the pungent sensation refers to: uncomfortable feeling of pain sense of the throat and the oral cavity in the experience process of the nicotine buccal product; bitter and astringent feel means: uncomfortable feeling of the bitter taste of the throat and the mouth in the experience process of the nicotine buccal product; the sense of satisfaction refers to: the nicotine buccal product has comprehensive feeling on the strength, concentration and aroma of the product and on the inside of the mouth of the sense organ; the flavor refers to: the sensory primary difference performance of the nicotine buccal product is distinguished from other similar nicotine buccal products. Wherein the taste evaluation scoring criteria of the nicotine buccal product are shown in table 1 below:
TABLE 1 taste evaluation scoring criteria for Nicotine buccal products
The nicotine buccal products of examples 1 to 5 containing the antibacterial and antioxidant composition and the nicotine buccal product of comparative example 1 were subjected to taste evaluation tests, and the evaluation results are shown in table 2 below:
table 2 results of taste evaluation of the Nicotine buccal products containing the antibacterial and antioxidant compositions of examples 1 to 5 and the Nicotine buccal product of comparative example 1
| Project | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Comparative example 1 |
| Irritation (irritation) | 18 | 16 | 18 | 17 | 18 | 15 |
| Spicy feel | 19 | 17 | 17 | 16 | 19 | 15 |
| Bitter and astringent feel | 17 | 15 | 17 | 15 | 18 | 16 |
| Feeling of satisfaction | 18 | 16 | 18 | 17 | 18 | 17 |
| Flavor of | 16 | 17 | 16 | 15 | 17 | 13 |
| Total score | 88 | 81 | 86 | 80 | 90 | 76 |
As is clear from the evaluation results of Table 2, the nicotine buccal products (examples 1 to 5) containing the antibacterial and antioxidant composition prepared by the component proportions and the preparation method of the application are particularly excellent in irritation, pungency, bitterness, satisfaction and flavor, and are improved in irritation, pungency, satisfaction and flavor compared with the nicotine buccal products (comparative example 1).
Evaluation of bacteriostatic Effect
Helicobacter in the mouth pylorus is distributed in plaque, dorsum lingualis, saliva and gingival crevicular fluid, and is one of the factors causing periodontitis, halitosis, recurrent oral ulcer, chronic pharyngitis. Helicobacter pylori in the mouth and stomach has homology. The swallowing action of the oral cavity can send dental plaque and helicobacter pylori in saliva into intestines and stomach from esophagus, so that gastritis is caused; helicobacter pylori in the stomach may also enter the mouth by the route of oesophageal reflux.
Streptococcus mutans is gram-positive coccus, one of the largest-proportion Streptococcus in the natural flora of the oral cavity, and one of the main components of dental plaque. Caries is a bacterial infectious disease that occurs in dental hard tissues, with the highest incidence among oral diseases. Streptococcus mutans is the primary pathogen of caries.
Evaluation was performed with reference to WS/T650-2019, antibacterial and bacteriostatic Effect evaluation method.
The antibacterial rate is more than or equal to 50-90 percent, and the antibacterial effect is judged. The antibacterial rate is more than or equal to 90 percent, and the antibacterial effect is higher.
The nicotine buccal products of examples 1 to 5 containing the antibacterial and antioxidant composition and the nicotine buccal product of comparative example 1 were evaluated for antibacterial effect, and the evaluation results are shown in table 3 below:
table 3 results of evaluation of antibacterial effect of Nicotine buccal products containing antibacterial and antioxidant compositions of examples 1 to 5 and Nicotine buccal product of comparative example 1
As can be seen from the evaluation results of Table 3, the nicotine buccal product (example 1-example 5) containing the antibacterial and antioxidant composition prepared by the component proportion and the preparation method of the application has a strong antibacterial effect, while the nicotine buccal product (comparative example 1) prepared by the lack of the antibacterial and antioxidant composition has an antibacterial effect, but the effect is not obvious. The content of the antibacterial and antioxidant composition is not in the range of the application, and the prepared nicotine buccal product (comparative examples 2-4) containing the antibacterial and antioxidant composition has antibacterial effect, but the effect is not obvious, but the antibacterial effect is stronger than that of the nicotine buccal product (comparative example 1) prepared by lacking the antibacterial and antioxidant composition component. The nicotine buccal product (comparative examples 5-7) containing the antibacterial and antioxidant composition prepared by lacking one or more components in the antibacterial and antioxidant composition has antibacterial effect, but the effect is not obvious, wherein the nicotine buccal product (comparative example 5) containing the antibacterial and antioxidant composition prepared by lacking a single component in the antibacterial and antioxidant composition has better antibacterial effect than the nicotine buccal product (comparative examples 6-7) containing the antibacterial and antioxidant composition prepared by lacking multiple components in the antibacterial and antioxidant composition. Therefore, the nicotine buccal product containing the antibacterial and antioxidant composition realizes the antibacterial effect through the synergistic effect of hericium erinaceus polysaccharide, procyanidine, resveratrol, ellagic acid, rosmarinic acid and hyperoside in the antibacterial and antioxidant composition.
Evaluation of antioxidant efficacy
The DPPH scavenging measurement method is applied to quantitative measurement of antioxidant capacity of biological samples, phenols and other substances, and the measurement principle is that the DPPH (1, 1-diphenyl-2-trinitrophenylhydrazine) free radical has single electron, has strong absorption at 517nm, and the alcohol solution has purple characteristic. When the free radical scavenger exists, the DPPH single electron is paired with the free radical scavenger, so that the absorption of the free radical scavenger gradually disappears, the color development reaction of the alcohol solution starts to weaken, the color development degree is quantitatively related to the number of the electrons accepted by the alcohol solution, and therefore, the rapid quantitative analysis can be performed by a spectrophotometer.
DPPH inhibition rate detection method:
preparation of sample dilution 1g of the nicotine buccal product containing the antibacterial and antioxidant composition of examples 1 to 5 and the nicotine buccal product of comparative example 1 were taken and diluted 100 times with ultrapure water to prepare sample dilutions.
(1) 2ml of sample diluent and 0.5ml of DPPH solution with the concentration of 0.5mmol/ml are added into the same test tube with a plug successively, the mixture is shaken uniformly, the mixture is placed for 20min at 37 ℃ in the dark, and the absorbance Ai is measured at 514nm by taking methanol as a blank.
(2) 0.5ml of a DPPH solution of 0.5mmol/ml was mixed with 2ml of methanol, shaken well, left to stand in the dark at 37℃for 20min, and the absorbance Ao was measured at 514nm with methanol as a blank.
(3) 2ml of the sample dilution was mixed with 0.5ml of methanol, shaken well, left to stand in the dark at 37℃for 20min, and the absorbance Aj was measured at 514nm with methanol as a blank.
Calculation of inhibition of DPPH by sample: inhibition ratio (%) = [ 1- (Ai-Aj)/Ao ] x 100
Wherein Ai is absorbance of DPPH solution after adding antioxidant; ao is the absorbance of the DPPH solution without antioxidant; aj is the absorbance of the sample at the measurement wavelength. Aj is introduced in the formula to eliminate the interference of the sample diluent itself on the assay. The greater the inhibition, the higher the antioxidant activity.
The DPPH inhibition rate test results of the nicotine buccal products of examples 1 to 5 of the present application containing the antibacterial and antioxidant composition and the nicotine buccal product of comparative example 1 are shown in FIG. 1. As can be seen from fig. 1, the nicotine buccal preparation (examples 1 to 5) containing the antibacterial and antioxidant composition of the present application has a better antioxidant effect than the nicotine buccal preparation (comparative example 1). Therefore, the application has remarkable effect in the experiment through the antioxidation synergistic effect of the hericium erinaceus polysaccharide, the procyanidine, the resveratrol, the ellagic acid, the rosmarinic acid and the hyperin.
In summary, compared with the prior art, the nicotine buccal product containing the antibacterial and antioxidant composition and the preparation method thereof have the following advantages:
the antibacterial and antioxidant composition is added on the basis of the existing nicotine buccal product, so that the nicotine buccal product has antibacterial and antioxidant effects while obtaining the satisfaction of nicotine. The antibacterial and antioxidant composition realizes antibacterial and antioxidant effects through synergistic effects of Hericium erinaceus polysaccharide, procyanidine, resveratrol, ellagic acid, rosmarinic acid and hyperoside. The nicotine buccal product containing the antibacterial and antioxidant composition has obvious antibacterial effect, can improve the related sanitation of the oral cavity and reduce the occurrence probability of diseases of bacterial infection; has antioxidant effect, and has health promoting effect in scavenging free radicals and inhibiting inflammation.
While the application has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the application. Therefore, the protection scope of the application is subject to the protection scope of the claims.
Claims (10)
1. A nicotine buccal product containing an antibacterial and antioxidant composition is characterized by comprising the antibacterial and antioxidant composition, wherein the antibacterial and antioxidant composition is a mixture of hericium erinaceus polysaccharide, procyanidine, resveratrol, ellagic acid, rosmarinic acid and hyperoside.
2. A nicotine buccal product comprising an antibacterial and antioxidative composition according to claim 1, further comprising one or more of nicotine and/or nicotine salts, sweeteners, flavoring agents, fillers, disintegrants, preservatives, humectants, distilled water.
3. A nicotine buccal product comprising a bacteriostatic and antioxidant composition according to claim 2, which comprises the following components in parts by weight:
6-30 parts of antibacterial and antioxidant composition, 0.3-6 parts of nicotine and/or nicotine salt, 1-10 parts of sweetener, 1-10 parts of corrigent, 20-60 parts of filler, 1-10 parts of disintegrating agent, 0.1-1 part of preservative, 1-10 parts of humectant and 20-50 parts of distilled water.
4. A nicotine buccal product comprising an antibacterial and antioxidative composition according to claim 3, characterized by comprising the following components in parts by weight:
6-25 parts of antibacterial and antioxidant composition, 1-3 parts of nicotine and/or nicotine salt, 1-5 parts of sweetener, 1-5 parts of corrigent, 30-50 parts of filler, 5-10 parts of disintegrating agent, 0.1-0.5 part of preservative, 5-10 parts of humectant and 30-40 parts of distilled water.
5. A nicotine buccal product comprising an antibacterial and antioxidant composition according to claim 3, wherein the antibacterial and antioxidant composition comprises, by weight, 1-4 parts of hericium erinaceus polysaccharide, 1-4 parts of procyanidine, 1-4 parts of resveratrol, 1-4 parts of ellagic acid, 1-4 parts of rosmarinic acid and 1-4 parts of hyperin.
6. The nicotine buccal product comprising an antibacterial and antioxidative composition of claim 5, wherein the nicotine salt is nicotine benzoate and the sweetener is one or more selected from the group consisting of erythritol, xylitol, acesulfame potassium.
7. The nicotine buccal product comprising an antibacterial and antioxidative composition of claim 6, wherein the flavoring agent is selected from one or more of peppermint essence, strawberry essence, lemon essence, and the filler is selected from one or more of sodium alginate, microcrystalline cellulose sodium, acacia, guar gum, pregelatinized starch, methylcellulose, and sodium hydroxymethyl cellulose.
8. A nicotine buccal product comprising an antibacterial and antioxidative composition according to claim 7, wherein said disintegrant is selected from one or more of citric acid, malic acid, sodium carbonate, sodium bicarbonate.
9. The nicotine buccal product comprising an antibacterial and antioxidative composition of claim 8, wherein the preservative is selected from one of potassium sorbate and sodium benzoate, and the humectant is glycerol.
10. A method of preparing a nicotine buccal product comprising a bacteriostatic antioxidant composition according to any one of claims 3 to 9 comprising the steps of:
s1, weighing the components according to parts by weight;
s2, slowly adding a filler, a disintegrating agent, a sweetener, a preservative and a bacteriostatic and antioxidant composition into distilled water, uniformly stirring by a magnetic stirrer at normal temperature, stirring for 40-45min at the rotating speed of 230-250r/min, drying at 55-60 ℃, crushing by a crusher, and sieving by a 50-60-mesh sieve to obtain mixed powder;
s3, uniformly mixing nicotine and/or nicotine salt, a humectant and a flavoring agent to obtain a mixed solution;
s4, adding the mixed solution obtained in the step S3 into the mixed powder obtained in the step S2, and stirring at a rotating speed of 100-150r/min for 20-30min to obtain a mixture;
s5, placing the mixture obtained in the step S4 for 12 hours, and bagging according to the specification that each bag is 0.6g, thus obtaining the nicotine buccal product containing the antibacterial and antioxidant composition.
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