CN116035250A - Nicotine buccal product containing compound antioxidant and preparation method thereof - Google Patents
Nicotine buccal product containing compound antioxidant and preparation method thereof Download PDFInfo
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- CN116035250A CN116035250A CN202310117910.7A CN202310117910A CN116035250A CN 116035250 A CN116035250 A CN 116035250A CN 202310117910 A CN202310117910 A CN 202310117910A CN 116035250 A CN116035250 A CN 116035250A
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
Abstract
The invention discloses a nicotine buccal product containing a compound antioxidant and a preparation method thereof, and relates to the technical field of buccal products. The buccal product comprises the following components in parts by weight: 2-5 parts of grape seed extract inclusion compound, 0.2-0.5 part of vitamin E, 4-5 parts of nicotine salt, 30-50 parts of filler, 3-5 parts of sweetener, 0.3-0.5 part of cooling agent, 0.3-0.5 part of dispersing agent, 1-2 parts of pH regulator, 3-5 parts of essence, 3-5 parts of propylene glycol and 30-35 parts of deionized water. The grape seed extract inclusion compound is compounded with the vitamin E, so that the oxidation yellowing and deterioration of the nicotine buccal product are inhibited, the antioxidation effect is enhanced, and the shelf life is prolonged. In addition, the hydroxypropyl-beta-cyclodextrin embedded grape seed extract is applied to the nicotine buccal product, so that the antioxidant and antibacterial effects are enhanced, and the action time is prolonged.
Description
Technical Field
The invention relates to the technical field of buccal products, in particular to a nicotine buccal product containing a compound antioxidant and a preparation method thereof.
Background
Traditional chemical synthesis preservatives such as potassium sorbate and the like are usually added into the nicotine buccal product to achieve the effects of bacteriostasis and preservation and prolonging the shelf life, and the traditional chemical synthesis preservatives are easy to bring peculiar smell and harm the body health. In addition, the buccal product of nicotine has higher water content, and the nicotine is easy to oxidize and turn yellow, mold and deteriorate during storage. Therefore, a nicotine buccal product containing a compound antioxidant needs to be sought, and the compound antioxidant is used for replacing a chemical synthesis preservative to play a role in inhibiting bacteria and preserving and prolonging the shelf life. The grape seed extract contains procyanidine, epicatechin and other substances, is one of the most effective antioxidants found from the plant kingdom so far, has the functions of antioxidation, bacteriostasis and the like, but the procyanidine in the grape seed extract is unstable in property and easy to decompose in visible light, so that an inclusion or microencapsulation technology is required to be applied to isolate the grape seed extract from the outside, the stability of the grape seed extract is improved, and the original property and biological activity of the grape seed extract are maintained; vitamin E is a fat-soluble vitamin necessary for human body, and is an important antioxidant substance in the non-enzymatic antioxidant system of the organism. The grape seed extract and vitamin E are compounded to serve as an antioxidant to replace a chemical synthesis preservative, so that the grape seed extract and vitamin E can play a role in inhibiting bacteria and preserving and prolonging the shelf life.
Disclosure of Invention
In order to solve the technical problems, the invention provides a nicotine buccal product containing a compound antioxidant and a preparation method thereof. The method specifically comprises the following technical scheme:
in a first aspect, a nicotine buccal product containing a compound antioxidant is provided, comprising the following components in parts by weight:
2-5 parts of grape seed extract inclusion compound, 0.2-0.5 part of vitamin E, 4-5 parts of nicotine salt, 30-50 parts of filler, 3-5 parts of sweetener, 0.3-0.5 part of cooling agent, 0.3-0.5 part of dispersing agent, 1-2 parts of pH regulator, 3-5 parts of essence, 3-5 parts of propylene glycol and 30-35 parts of deionized water.
Further, the weight ratio of the grape seed extract inclusion compound to the vitamin E is 1: (0.04-0.2).
Further, the grape seed extract inclusion compound is prepared by embedding grape seed extract by hydroxypropyl-beta-cyclodextrin.
Preferably, the inclusion rate of the grape seed extract in the grape seed extract inclusion compound is 98.75%.
Further, the preparation method of the grape seed extract inclusion compound comprises the following steps:
(1) Preparing hydroxypropyl-beta-cyclodextrin into water solution with mass concentration of 20-25%, and adding grape seed extract to obtain mixture solution;
(2) Stirring the mixture solution obtained in the step (1) for 2-3 hours under a constant temperature magnetic stirrer with the temperature of 40-45 ℃ and filtering;
(3) And (3) placing the filtrate obtained in the step (2) in a refrigerator at the temperature of between 20 ℃ below zero and 25 ℃ below zero for freezing for 24 to 30 hours, and then placing in a freeze dryer for freeze drying for 24 to 30 hours to obtain the grape seed extract inclusion compound.
Further, the nicotine salt is selected from one of nicotine tartrate, nicotine salicylate and nicotine malate.
Further, the filler is selected from one of microcrystalline cellulose and water-insoluble plant cellulose; the sweetener is selected from one or more of xylitol, maltitol and acesulfame potassium.
Further, the cooling agent is selected from a mixture of N-ethyl-2-isopropyl-5-methyl-cyclohexane carboxamide (WS-3) and N,2, 3-trimethyl-2-isopropyl butanamide (WS-23).
Preferably, the weight ratio of the N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide to the N,2, 3-trimethyl-2-isopropyl butyramide is 3:1.
Further, the dispersing agent is selected from one or more of acacia, xanthan gum and carrageenan.
Further, the PH regulator is selected from one or more of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, phosphate, hydroxide and tris (hydroxymethyl) aminomethane; the essence is one or more selected from herba Menthae essence, lemon essence, vanilla essence, and mandarin orange essence.
In a second aspect, there is provided a method of preparing a nicotine buccal product comprising a formulated antioxidant as described in the first aspect, comprising the steps of:
s1, taking filler, grape seed extract inclusion compound, vitamin E, sweetener, cooling agent, dispersing agent and pH regulator according to the weight parts, uniformly mixing, adding deionized water and propylene glycol, and uniformly mixing for 5-10min by a stirrer to obtain a mixed solution;
s2, taking essence and nicotine salt according to the weight parts, and uniformly stirring and mixing to obtain mixed powder;
s3, adding the mixed solution obtained in the step S1 into the mixed powder obtained in the step S2, stirring and mixing uniformly for 5-10min, sieving under the condition of 40-45 meshes, and bagging according to the specification that each bag is 0.4 g;
s4, sterilizing the packaged product obtained in the step S3 by ultraviolet rays for 30-35min to obtain the nicotine buccal product containing the compound antioxidant.
The grape seed extract inclusion compound is compounded with the vitamin E, so that the oxidation yellowing and deterioration of the nicotine buccal product are inhibited, the antioxidation effect is enhanced, and the shelf life is prolonged. In addition, the grape seed extract inclusion compound prepared by embedding the grape seed extract with the hydroxypropyl-beta-cyclodextrin is applied to a nicotine buccal product, so that the effect of slowly releasing nicotine is achieved, the antioxidation and antibacterial effects of the grape seed extract inclusion compound are enhanced, and the action time is prolonged.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 shows the results of measuring the total number of colonies of the nicotine buccal preparation of example 1 and comparative examples 1 to 2 of the present invention.
Figure 2 is the results of week 1 of the stability test of the nicotine buccal formulations of example 1, comparative examples 1-2 of the present invention.
Figure 3 is the results of the stability test for the nicotine buccal preparation of example 1, comparative example 1-2 of the present invention at week 3.
Figure 4 is the result of the stability test of the nicotine buccal preparation of example 1, comparative example 1-2 of the present invention at week 5.
Figure 5 is the 7 th week test result of the stability test of the nicotine buccal preparation of example 1, comparative example 1-2 of the present invention.
Figure 6 is the results of the stability test of the nicotine buccal preparation of example 1, comparative example 1-2 of the present invention at week 9.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely, and it is apparent that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be understood that the terms "comprises" and "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It is also to be understood that the terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in this specification and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
It should be further understood that the term "and/or" as used in the present specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations.
In order to more fully understand the technical content of the present invention, the following description and description of the technical solution of the present invention will be further presented with reference to specific embodiments.
The preparation method of the nicotine buccal product containing the compound antioxidant comprises the following steps:
s1, taking filler, grape seed extract inclusion compound, vitamin E, sweetener, cooling agent, dispersing agent and pH regulator according to the weight parts, uniformly mixing, adding deionized water and propylene glycol, and uniformly mixing for 5-10min by a stirrer to obtain a mixed solution;
s2, taking essence and nicotine salt according to the weight parts, and uniformly stirring and mixing to obtain mixed powder;
s3, adding the mixed solution obtained in the step S1 into the mixed powder obtained in the step S2, stirring and mixing uniformly for 5-10min, sieving under the condition of 40-45 meshes, and bagging according to the specification that each bag is 0.4 g;
s4, sterilizing the packaged product obtained in the step S3 by ultraviolet rays for 30-35min to obtain the nicotine buccal product containing the compound antioxidant.
The grape seed extract inclusion compound mentioned in the invention is prepared by embedding grape seed extract with hydroxypropyl-beta-cyclodextrin. The inclusion rate of the grape seed extract in the grape seed extract inclusion compound is 98.75%.
The preparation method of the grape seed extract inclusion compound comprises the following steps:
(1) Preparing hydroxypropyl-beta-cyclodextrin into water solution with mass concentration of 20-25%, and adding grape seed extract to obtain mixture solution;
(2) Stirring the mixture solution obtained in the step (1) for 2-3 hours under a constant temperature magnetic stirrer with the temperature of 40-45 ℃ and filtering;
(3) And (3) placing the filtrate obtained in the step (2) in a refrigerator at the temperature of between 20 ℃ below zero and 25 ℃ below zero for freezing for 24 to 30 hours, and then placing in a freeze dryer for freeze drying for 24 to 30 hours to obtain the grape seed extract inclusion compound.
Example 1
A nicotine buccal product containing a compound antioxidant comprises the following components in parts by weight:
5 parts of grape seed extract inclusion compound, 0.2 part of vitamin E, 4.7 parts of nicotine salt, 45 parts of filler, 3 parts of sweetener, 0.5 part of cooling agent, 0.3 part of dispersing agent, 1 part of pH regulator, 5 parts of essence, 3 parts of propylene glycol and 33 parts of deionized water.
The nicotine salt is malic acid nicotine salt, the filler is microcrystalline cellulose, the sweetener is acesulfame potassium, the cooling agent is a mixture of N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide and N,2, 3-trimethyl-2-isopropyl butyramide, the weight ratio of N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide (WS-3 cooling agent) to N,2, 3-trimethyl-2-isopropyl butyramide (WS-23 cooling agent) is 3:1, the dispersing agent is gum arabic, the PH regulator is sodium bicarbonate, and the essence is peppermint essence.
Wherein the grape seed extract inclusion compound is prepared by embedding grape seed extract with hydroxypropyl-beta-cyclodextrin. The inclusion rate of the grape seed extract in the grape seed extract inclusion compound is 98.75%.
The preparation method of the grape seed extract inclusion compound of the embodiment 1 comprises the following steps:
(1) Preparing hydroxypropyl-beta-cyclodextrin into 20% aqueous solution, and adding grape seed extract to obtain mixture solution;
(2) Stirring the mixture solution obtained in the step (1) for 2 hours under a constant temperature magnetic stirrer with the temperature of 40 ℃, and filtering;
(3) And (3) freezing the filtrate obtained in the step (2) in a refrigerator at the temperature of minus 20 ℃ for 24 hours, and then freeze-drying in a freeze dryer for 24 hours to obtain the grape seed extract inclusion compound.
The preparation method of grape seed extract inclusion compound of examples 2 to 4 and comparative examples 4 to 5 is the same as that of example 1.
A method of preparing a nicotine buccal product comprising a formulated antioxidant of example 1 comprising the steps of:
s1, taking filler, grape seed extract inclusion compound, vitamin E, sweetener, cooling agent, dispersing agent and pH regulator according to the weight parts, uniformly mixing, adding deionized water and propylene glycol, and uniformly mixing for 5min by a stirrer to obtain a mixed solution;
s2, taking essence and nicotine salt according to the weight parts, and uniformly stirring and mixing to obtain mixed powder;
s3, adding the mixed solution obtained in the step S1 into the mixed powder obtained in the step S2, stirring and mixing uniformly for 10min, sieving under the condition of 40 meshes, and bagging according to the specification that each bag is 0.4 g;
s4, sterilizing the packaged product obtained in the step S3 by ultraviolet rays for 30-35min to obtain the nicotine buccal product containing the compound antioxidant.
Examples 2-4, comparative examples 3-7 were prepared in the same manner as example 1 using the nicotine buccal preparation containing the formulated antioxidant.
Example 2
A nicotine buccal product containing a compound antioxidant comprises the following components in parts by weight:
4 parts of grape seed extract inclusion compound, 0.3 part of vitamin E, 4.7 parts of nicotine salt, 48 parts of filler, 3 parts of sweetener, 0.4 part of cooling agent, 0.3 part of dispersing agent, 1 part of pH regulator, 3 parts of essence, 4 parts of propylene glycol and 32 parts of deionized water.
The nicotine salt is malic acid nicotine salt, the filler is microcrystalline cellulose, the sweetener is acesulfame potassium, the cooling agent is a mixture of N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide and N,2, 3-trimethyl-2-isopropyl butyramide, the weight ratio of the N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide to the N,2, 3-trimethyl-2-isopropyl butyramide is 3:1, the dispersing agent is gum arabic, the PH regulator is sodium bicarbonate, and the essence is peppermint essence.
Wherein the grape seed extract inclusion compound is prepared by embedding grape seed extract with hydroxypropyl-beta-cyclodextrin. The inclusion rate of the grape seed extract in the grape seed extract inclusion compound is 98.75%.
Example 3
A nicotine buccal product containing a compound antioxidant comprises the following components in parts by weight:
3 parts of grape seed extract inclusion compound, 0.4 part of vitamin E, 4.7 parts of nicotine salt, 49 parts of filler, 4 parts of sweetener, 0.4 part of cooling agent, 0.4 part of dispersing agent, 1 part of pH regulator, 4 parts of essence, 3 parts of propylene glycol and 31 parts of deionized water.
The nicotine salt is malic acid nicotine salt, the filler is microcrystalline cellulose, the sweetener is acesulfame potassium, the cooling agent is a mixture of N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide and N,2, 3-trimethyl-2-isopropyl butyramide, the weight ratio of the N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide to the N,2, 3-trimethyl-2-isopropyl butyramide is 3:1, the dispersing agent is gum arabic, the PH regulator is sodium bicarbonate, and the essence is peppermint essence.
Wherein the grape seed extract inclusion compound is prepared by embedding grape seed extract with hydroxypropyl-beta-cyclodextrin. The inclusion rate of the grape seed extract in the grape seed extract inclusion compound is 98.75%.
Example 4
A nicotine buccal product containing a compound antioxidant comprises the following components in parts by weight:
2 parts of grape seed extract inclusion compound, 0.4 part of vitamin E, 4.7 parts of nicotine salt, 47 parts of filler, 4 parts of sweetener, 0.3 part of cooling agent, 0.4 part of dispersing agent, 2 parts of pH regulator, 4 parts of essence, 5 parts of propylene glycol and 30 parts of deionized water.
The nicotine salt is malic acid nicotine salt, the filler is microcrystalline cellulose, the sweetener is acesulfame potassium, the cooling agent is a mixture of N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide and N,2, 3-trimethyl-2-isopropyl butyramide, the weight ratio of the N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide to the N,2, 3-trimethyl-2-isopropyl butyramide is 3:1, the dispersing agent is gum arabic, the PH regulator is sodium bicarbonate, and the essence is peppermint essence.
Wherein the grape seed extract inclusion compound is prepared by embedding grape seed extract with hydroxypropyl-beta-cyclodextrin. The inclusion rate of the grape seed extract in the grape seed extract inclusion compound is 98.75%.
Comparative example 1
The common nicotine buccal product on the market contains the chemical preservative potassium sorbate.
Comparative example 2
The nicotine buccal product is common in the market, but does not contain chemical preservative potassium sorbate.
Comparative example 3
A nicotine buccal product containing a compound antioxidant comprises the following components in parts by weight:
5 parts of grape seed extract, 0.2 part of vitamin E, 4.7 parts of nicotine salt, 45 parts of filler, 3 parts of sweetener, 0.5 part of cooling agent, 0.3 part of dispersing agent, 1 part of pH regulator, 5 parts of essence, 3 parts of propylene glycol and 33 parts of deionized water.
The nicotine salt is malic acid nicotine salt, the filler is microcrystalline cellulose, the sweetener is acesulfame potassium, the cooling agent is a mixture of N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide and N,2, 3-trimethyl-2-isopropyl butyramide, the weight ratio of the N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide to the N,2, 3-trimethyl-2-isopropyl butyramide is 3:1, the dispersing agent is gum arabic, the PH regulator is sodium bicarbonate, and the essence is peppermint essence.
Comparative example 4
A nicotine buccal product containing a compound antioxidant comprises the following components in parts by weight:
5 parts of grape seed extract inclusion compound, 4.7 parts of nicotine salt, 45 parts of filler, 3 parts of sweetener, 0.5 part of cooling agent, 0.3 part of dispersing agent, 1 part of pH regulator, 5 parts of essence, 3 parts of propylene glycol and 33 parts of deionized water.
The nicotine salt is malic acid nicotine salt, the filler is microcrystalline cellulose, the sweetener is acesulfame potassium, the cooling agent is a mixture of N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide and N,2, 3-trimethyl-2-isopropyl butyramide, the weight ratio of the N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide to the N,2, 3-trimethyl-2-isopropyl butyramide is 3:1, the dispersing agent is gum arabic, the PH regulator is sodium bicarbonate, and the essence is peppermint essence.
Wherein the grape seed extract inclusion compound is prepared by embedding grape seed extract with hydroxypropyl-beta-cyclodextrin. The inclusion rate of the grape seed extract in the grape seed extract inclusion compound is 98.75%.
Comparative example 5
A nicotine buccal product containing a compound antioxidant comprises the following components in parts by weight:
6 parts of grape seed extract inclusion compound, 0.2 part of vitamin E, 4.7 parts of nicotine salt, 45 parts of filler, 3 parts of sweetener, 0.5 part of cooling agent, 0.3 part of dispersing agent, 1 part of pH regulator, 5 parts of essence, 3 parts of propylene glycol and 33 parts of deionized water.
The nicotine salt is malic acid nicotine salt, the filler is microcrystalline cellulose, the sweetener is acesulfame potassium, the cooling agent is a mixture of N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide and N,2, 3-trimethyl-2-isopropyl butyramide, the weight ratio of the N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide to the N,2, 3-trimethyl-2-isopropyl butyramide is 3:1, the dispersing agent is gum arabic, the PH regulator is sodium bicarbonate, and the essence is peppermint essence.
Wherein the grape seed extract inclusion compound is prepared by embedding grape seed extract with hydroxypropyl-beta-cyclodextrin. The inclusion rate of the grape seed extract in the grape seed extract inclusion compound is 98.75%.
Comparative example 6
A nicotine buccal product containing a compound antioxidant comprises the following components in parts by weight:
5 parts of potassium sorbate, 4.7 parts of nicotine salt, 45 parts of filler, 3 parts of sweetener, 0.5 part of cooling agent, 0.3 part of dispersing agent, 1 part of pH regulator, 5 parts of essence, 3 parts of propylene glycol and 33 parts of deionized water.
The nicotine salt is malic acid nicotine salt, the filler is microcrystalline cellulose, the sweetener is acesulfame potassium, the cooling agent is a mixture of N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide and N,2, 3-trimethyl-2-isopropyl butyramide, the weight ratio of the N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide to the N,2, 3-trimethyl-2-isopropyl butyramide is 3:1, the dispersing agent is gum arabic, the PH regulator is sodium bicarbonate, and the essence is peppermint essence.
Comparative example 7
A nicotine buccal product containing a compound antioxidant comprises the following components in parts by weight:
4.7 parts of nicotine salt, 45 parts of filler, 3 parts of sweetener, 0.5 part of cooling agent, 0.3 part of dispersing agent, 1 part of pH regulator, 5 parts of essence, 3 parts of propylene glycol and 33 parts of deionized water.
The nicotine salt is malic acid nicotine salt, the filler is microcrystalline cellulose, the sweetener is acesulfame potassium, the cooling agent is a mixture of N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide and N,2, 3-trimethyl-2-isopropyl butyramide, the weight ratio of the N-ethyl-2-isopropyl-5-methyl-cyclohexane formamide to the N,2, 3-trimethyl-2-isopropyl butyramide is 3:1, the dispersing agent is gum arabic, the PH regulator is sodium bicarbonate, and the essence is peppermint essence.
Sensory evaluation
(1) Volunteer screening: 12 panelists with high taste recognition capability and healthy and disease-free subjects were selected for sensory evaluation. Panellists were not allowed to smoke or drink during the 2h prior to assessment and were not allowed to eat food with a severe smell.
(2) Sensory evaluation method: and taking one bag of buccal product at a time, placing the buccal product between the upper lip and the gingiva, sensing the flavor and the taste of the buccal product, and evaluating. Each buccal product is tasted for 5min, then spitted out, rinsed 3 times until no residual taste exists in the oral cavity, the next buccal product is measured by the same method after 10min, and finally the comprehensive evaluation result is taken as a test result.
The nicotine buccal formulations of examples 1-4 and comparative examples 1-7 containing the formulated antioxidants were subjected to sensory evaluation tests, the test results are shown in table 1 below:
table 1 results of sensory evaluation test of the Nicotine buccal products containing Compound antioxidant of examples 1 to 4 and comparative examples 1 to 7
| Examples/comparative examples | Test results |
| Example 1 | No foreign odor, fragrant smell, good taste |
| Example 2 | No foreign odor, fragrant smell, good taste |
| Example 3 | No foreign odor, fragrant smell, good taste |
| Example 4 | Has no foreign flavor, slightly fragrant smell, and good taste |
| Comparative example 1 | Has peculiar smell, light fragrance and uncomfortable taste |
| Comparative example 2 | Has light fragrance, no foreign flavor and moderate taste |
| Comparative example 3 | Has light fragrance, no foreign odor and moderate taste |
| Comparative example 4 | Has light fragrance, no foreign odor and moderate taste |
| Comparative example 5 | Has light fragrance, no foreign odor and moderate taste |
| Comparative example 6 | Has light fragrance, peculiar smell and uncomfortable taste |
| Comparative example 7 | Has light fragrance, peculiar smell and uncomfortable taste |
As can be seen from the test results in Table 1, the nicotine buccal product containing the compound antioxidant prepared by the components of the embodiment of the invention has no peculiar smell, has unique pleasant fragrance of grape seed extract, and releases fragrance in the use process. The nicotine buccal product (comparative example 6) containing the compound antioxidant, which is prepared by replacing the grape seed extract inclusion compound and vitamin E of the invention with the traditional chemical synthesis preservative potassium sorbate, has poorer sensory evaluation test results. The components of the nicotine buccal product containing the compound antioxidant lack vitamin E (comparative example 4) or grape seed extract inclusion compound and vitamin E in a weight ratio outside the scope of the present application (comparative example 5) or lack grape seed extract inclusion compound and vitamin E (comparative example 7), have a lighter fragrance, and the test results for the lack of multiple components are worse than the test results for the lack of a single component. Therefore, the slow release effect of the nicotine buccal product is improved by compounding the grape seed extract inclusion compound and the vitamin. In addition, grape seed extract can cause the problem of lighter fragrance of the nicotine buccal product without embedding treatment.
Determination of colony count
The nicotine buccal preparation containing the compound antioxidant of example 1 was used as sample a, the nicotine buccal preparation of comparative example 1 (containing the chemical preservative potassium sorbate) was used as sample B, the nicotine buccal preparation of comparative example 2 (containing no chemical preservative potassium sorbate) was used as sample C, and the total number of colonies was measured at weeks 0, 1, 3, 5, 7 and 9 stored in a constant temperature and humidity oven, and the total number of colonies was measured with reference to GB 4789.2-2010 "food safety national standard food microbiology test total number of colonies measurement". The results of measuring the total number of colonies of the nicotine buccal preparation of example 1 and comparative example 1-2 are shown in FIG. 1.
As can be seen from fig. 1, the total number of colonies of sample a containing the compound antioxidant does not differ much from that of sample B prepared by adding the chemical preservative in the first week of storage, but after the 3 rd week of storage, the total number of colonies is significantly reduced compared with that of sample B, which indicates that the antibacterial and preservative capabilities of sample a prepared by adding the grape seed extract inclusion compound and vitamin E are stronger in the storage process, the quality of the sample a is better to preserve, and the shelf life of the sample a is longer. Compared with a sample C prepared without adding a preservative, the total number of the bacterial colonies of the sample A and the sample B is obviously lower than that of the sample C, the total number of the bacterial colonies of the sample C is rapidly increased in the storage process, the quality of the sample A is poor, the quality guarantee period of the product is short, and the total number of the bacterial colonies of the sample A in the storage process is obviously lower than that of the sample B and the sample C, so that the sample A meets the safety standard.
Stability test
The nicotine buccal product containing the compound antioxidant of example 1 was used as sample a, the nicotine buccal product of comparative example 1 (containing the chemical preservative potassium sorbate) was used as sample B, the nicotine buccal product of comparative example 2 (containing no chemical preservative potassium sorbate) was used as sample C, and the appearance was observed after storage in a constant temperature and humidity cabinet for weeks 1, 3, 5, 7, and 9. The test results at week 1, week 3, week 5, week 7, and week 9 are shown in fig. 2-6. Test results show that the sample A added with the grape seed extract inclusion compound and vitamin E is not easy to oxidize and yellow in the storage process, and the appearance state is complete; whereas sample B with the chemical preservative added gradually oxidized to yellow after the fifth week of placement; sample C without added preservative began oxidative yellowing after the third week, with the most severe oxidative yellowing and poor product status.
In summary, compared with the prior art, the nicotine buccal product containing the compound antioxidant has the following advantages:
the grape seed extract clathrate compound is compounded with vitamin E to inhibit the oxidative yellowing and deterioration of the nicotine buccal product, enhance the antioxidation effect and prolong the shelf life. In addition, the grape seed extract inclusion compound prepared by embedding the grape seed extract with the hydroxypropyl-beta-cyclodextrin is applied to a nicotine buccal product, so that the effect of slowly releasing nicotine is achieved, the antioxidation and antibacterial effects of the grape seed extract inclusion compound are enhanced, and the action time is prolonged.
While the invention has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the invention. Therefore, the protection scope of the invention is subject to the protection scope of the claims.
Claims (10)
1. The nicotine buccal product containing the compound antioxidant is characterized by comprising the following components in parts by weight:
2-5 parts of grape seed extract inclusion compound, 0.2-0.5 part of vitamin E, 4-5 parts of nicotine salt, 30-50 parts of filler, 3-5 parts of sweetener, 0.3-0.5 part of cooling agent, 0.3-0.5 part of dispersing agent, 1-2 parts of pH regulator, 3-5 parts of essence, 3-5 parts of propylene glycol and 30-35 parts of deionized water.
2. The nicotine buccal product comprising a compound antioxidant of claim 1 wherein the weight ratio of grape seed extract clathrate to vitamin E is 1: (0.04-0.2).
3. The nicotine buccal product comprising a compound antioxidant of claim 1 wherein the grape seed extract clathrate is prepared by embedding grape seed extract with hydroxypropyl-beta-cyclodextrin.
4. The nicotine buccal product comprising a compound antioxidant of claim 3, wherein the preparation method of the grape seed extract clathrate comprises the following steps:
(1) Preparing hydroxypropyl-beta-cyclodextrin into water solution with mass concentration of 20-25%, and adding grape seed extract to obtain mixture solution;
(2) Stirring the mixture solution obtained in the step (1) for 2-3 hours under a constant temperature magnetic stirrer with the temperature of 40-45 ℃ and filtering;
(3) And (3) placing the filtrate obtained in the step (2) in a refrigerator at the temperature of between 20 ℃ below zero and 25 ℃ below zero for freezing for 24 to 30 hours, and then placing in a freeze dryer for freeze drying for 24 to 30 hours to obtain the grape seed extract inclusion compound.
5. The nicotine buccal product comprising a compound antioxidant of claim 2, wherein the nicotine salt is selected from one of a tartrate nicotine salt, a salicylate nicotine salt and a malate nicotine salt.
6. The nicotine buccal product comprising a compound antioxidant of claim 5, wherein the filler is selected from one of microcrystalline cellulose and non-water soluble plant cellulose; the sweetener is selected from one or more of xylitol, maltitol and acesulfame potassium.
7. The nicotine buccal product comprising a formulated antioxidant of claim 6 wherein the cooling agent is selected from the group consisting of a mixture of N-ethyl-2-isopropyl-5-methyl-cyclohexane carboxamide and N,2, 3-trimethyl-2-isopropyl butyramide.
8. The nicotine buccal preparation comprising a compound antioxidant of claim 7, wherein the dispersant is selected from one or more of acacia, xanthan, carrageenan.
9. The nicotine buccal product comprising a combination antioxidant of claim 8, wherein the PH adjuster is selected from one or more of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, phosphate, hydroxide, tris (hydroxymethyl) aminomethane; the essence is one or more selected from herba Menthae essence, lemon essence, vanilla essence, and mandarin orange essence.
10. A method of preparing a nicotine buccal preparation comprising a compound antioxidant as claimed in any one of claims 1 to 9, comprising the steps of:
s1, taking filler, grape seed extract inclusion compound, vitamin E, sweetener, cooling agent, dispersing agent and pH regulator according to the weight parts, uniformly mixing, adding deionized water and propylene glycol, and uniformly mixing for 5-10min by a stirrer to obtain a mixed solution;
s2, taking essence and nicotine salt according to the weight parts, and uniformly stirring and mixing to obtain mixed powder;
s3, adding the mixed solution obtained in the step S1 into the mixed powder obtained in the step S2, stirring and mixing uniformly for 5-10min, sieving under the condition of 40-45 meshes, and bagging according to the specification that each bag is 0.4 g;
s4, sterilizing the packaged product obtained in the step S3 by ultraviolet rays for 30-35min to obtain the nicotine buccal product containing the compound antioxidant.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116649576A (en) * | 2023-06-14 | 2023-08-29 | 深圳市吉迩科技有限公司 | Nicotine buccal product containing antibacterial and antioxidant composition and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116649576A (en) * | 2023-06-14 | 2023-08-29 | 深圳市吉迩科技有限公司 | Nicotine buccal product containing antibacterial and antioxidant composition and preparation method thereof |
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