CN116636536A - Antiviral composition containing ningnanmycin and amino-oligosaccharin, preparation and application thereof - Google Patents
Antiviral composition containing ningnanmycin and amino-oligosaccharin, preparation and application thereof Download PDFInfo
- Publication number
- CN116636536A CN116636536A CN202310690889.XA CN202310690889A CN116636536A CN 116636536 A CN116636536 A CN 116636536A CN 202310690889 A CN202310690889 A CN 202310690889A CN 116636536 A CN116636536 A CN 116636536A
- Authority
- CN
- China
- Prior art keywords
- parts
- antiviral composition
- amino
- oligosaccharin
- ningnanmycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 65
- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 59
- AMNAZJFEONUVTD-KEWDHRJRSA-N (2s,3s,4s,5r,6r)-6-(4-amino-2-oxopyrimidin-1-yl)-4,5-dihydroxy-3-[[(2s)-3-hydroxy-2-[[2-(methylamino)acetyl]amino]propanoyl]amino]oxane-2-carboxamide Chemical compound O1[C@H](C(N)=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC)[C@H](O)[C@@H](O)[C@@H]1N1C(=O)N=C(N)C=C1 AMNAZJFEONUVTD-KEWDHRJRSA-N 0.000 title claims abstract description 46
- FEACDOXQOYCHKU-UHFFFAOYSA-N Gougerotin Natural products CNCC(=O)NC1=NC(=O)N(C=C1)C2OC(C(O)C(NC(=O)C(N)CO)C2O)C(=O)N FEACDOXQOYCHKU-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 201000010099 disease Diseases 0.000 claims abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 14
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims abstract description 9
- 240000003768 Solanum lycopersicum Species 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 21
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- 239000000945 filler Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000002270 dispersing agent Substances 0.000 claims description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 3
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 3
- 239000006229 carbon black Substances 0.000 claims description 3
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 3
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 claims description 3
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 3
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 239000000080 wetting agent Substances 0.000 claims description 3
- 230000003612 virological effect Effects 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 2
- 239000005909 Kieselgur Substances 0.000 claims 1
- 241000700605 Viruses Species 0.000 abstract description 12
- 239000000575 pesticide Substances 0.000 abstract description 5
- 241000196324 Embryophyta Species 0.000 description 12
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- -1 cytosine nucleoside Chemical class 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 239000002689 soil Substances 0.000 description 4
- 239000000375 suspending agent Substances 0.000 description 4
- 235000002566 Capsicum Nutrition 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 241000607479 Yersinia pestis Species 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical class C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- 241000758706 Piperaceae Species 0.000 description 2
- 241000208292 Solanaceae Species 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 235000012055 fruits and vegetables Nutrition 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 210000002845 virion Anatomy 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- CCLNWKPQPZBSEI-UHFFFAOYSA-N 2,3-diethoxypropan-1-ol Chemical compound CCOCC(CO)OCC CCLNWKPQPZBSEI-UHFFFAOYSA-N 0.000 description 1
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 1
- KXGFMDJXCMQABM-UHFFFAOYSA-N 2-methoxy-6-methylphenol Chemical compound [CH]OC1=CC=CC([CH])=C1O KXGFMDJXCMQABM-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000756943 Codonopsis Species 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000270834 Myristica fragrans Species 0.000 description 1
- 235000009421 Myristica fragrans Nutrition 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- 241000702308 Tomato yellow leaf curl virus Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 229940009868 aluminum magnesium silicate Drugs 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Natural products NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 1
- 229940104302 cytosine Drugs 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000008558 metabolic pathway by substance Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 239000001702 nutmeg Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 239000000447 pesticide residue Substances 0.000 description 1
- 239000005011 phenolic resin Substances 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The application relates to the technical field of biological pesticides, in particular to an antiviral composition containing ningnanmycin and amino-oligosaccharin, a preparation and application thereof. The antiviral composition comprises active ingredients of ningnanmycin and amino-oligosaccharin, wherein the mass ratio of the ningnanmycin to the amino-oligosaccharin is 1: (0.05-20). The application aims to provide an antiviral composition containing Ningnanmycin and amino-oligosaccharin, a preparation and application thereof, which are used for preventing and treating tomato virus diseases and solve the problems in the prior art.
Description
Technical Field
The application relates to the technical field of biological pesticides, in particular to an antiviral composition containing ningnanmycin and amino-oligosaccharin, a preparation and application thereof.
Background
Tomato virus (TYLCV) is a plant disease caused by a single-stranded RNA virus of the genus yellow leaf curl virus, and is mainly parasitic in Solanaceae crops such as tomato, capsicum, eggplant, etc. Such diseases can cause yellowing and curling of plant leaves, hampering photosynthesis and other growth processes, and affecting plant yield and quality.
Tomato virus diseases are mainly transmitted through white fly, and after sucking sap of infected plants, the insects can carry viruses and transfer the viruses to healthy plants so that the plants are infected. At present, no specific medicine or vaccine can cure the diseases, and common prevention and treatment measures comprise measures of avoiding planting solanaceae crops in a high virus active period, using a variety with strong virus resistance, killing infected plants and the like.
Ningnanmycin, the name Ningnanmycin, is an innovative biological pesticide developed by the institute of Chengdu biological research of the national academy of sciences, is a novel cytosine nucleoside peptide antibiotic, and is mainly used for preventing and treating crop virus diseases such as tomatoes, peppers, tobacco and the like at present by prolonging the incubation period of bacteria, destroying the virion structure, reducing the virion concentration and regulating the metabolism of organisms so as to enhance the disease resistance and immunity of plants.
Amino oligosaccharins are an active molecule popular in nature and are widely found in organisms such as plants, animals, microorganisms, etc. In agriculture, amino oligosaccharins can exert the following actions: promoting plant growth: the amino-oligosaccharins can be absorbed by plants, promote the development of root systems and the capability of absorbing moisture and nutrients, and improve the adaptability of the plants to natural environments; improving soil quality: the amino oligosaccharin can stimulate the growth of related flora, catalyze the metabolism of substances between bacteria and soil medium, so that the soil is richer, the organic matters are more, the ventilation is better, the drainage is smoother, the water and nutrition quality contained in the surface soil are increased, and the effects of promoting the growth of crops and improving the yield are achieved; enhancing the salt and alkali resistance and the disease and pest resistance: by enhancing the natural barrier effect of plants, the amino-oligosaccharin can enable crops to improve the resistance to adverse environments and diseases and insect pests, so that the performances of drought resistance, salt and alkali resistance, disease and insect pests resistance and the like are improved; promoting the quality of fruits and vegetables: the amino oligosaccharin is widely applied in the production process of fruits and vegetables, and is beneficial to improving the quality and nutritional ingredients of crops such as fruits, spices, peppers and the like, such as mouthfeel, color, flavor, aroma, vitamin content and the like.
Disclosure of Invention
The application aims to provide an antiviral composition containing Ningnanmycin and amino-oligosaccharin, a preparation and application thereof, which are used for preventing and treating tomato virus diseases and solve the problems in the prior art.
The auxiliary materials or carriers, such as emulsifying agent, wetting dispersant, thickening agent, antifreezing agent, stabilizing agent, preservative, disintegrating agent, binding agent and the like, are all conventional components in pesticide preparations. For example, the emulsifier can be selected from one or more of nonionic surfactant castor oil ethylene oxide adduct (EL 40 or EL 90), nonylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, phenethyl phenol polyoxyethylene polyoxypropylene ether and alkylphenol polyoxyethylene ether formaldehyde condensate; the wetting dispersant can be one or a mixture of more than two of sodium dodecyl sulfate, nekal BX, alkylphenol polyoxyethylene, salts of naphthalene sulfonic formaldehyde condensate or polyoxyethylene polyoxypropylene ether block copolymer according to any proportion; the thickener can be selected from any one or more of xanthan gum, carboxymethyl cellulose, sodium polyacrylate, aluminum magnesium silicate, gaseous silicon dioxide or attapulgite; the antifreezing agent can be selected from any one or more than one of ethylene glycol, propylene glycol, glycerol-diethyl ether diglycol or methyl propylene diglycol according to any proportion; the stabilizer can be selected from any one or more of 2, 6-di-tert-butyl-4-methylphenol (BHT), citric acid or Butyl Hydroxy Anisole (BHA); the disintegrating agent can be selected from any one or a mixture of a plurality of urea, bentonite, montmorillonite or sodium alginate; the binder can be selected from one or more of gelatin, acacia, xanthan gum, sodium tripolyphosphate, phenolic resin or polyvinylpyrrolidone; the filler can be one or more of kaolin, pottery clay and bentonite.
The application provides an antiviral composition containing ningnanmycin and amino-oligosaccharin, wherein the active ingredients of the antiviral composition comprise the ningnanmycin and the amino-oligosaccharin, and the mass ratio of the ningnanmycin to the amino-oligosaccharin is 1: (0.05-20).
In the above antiviral composition containing ningnanmycin and amino-oligosaccharin, as a preferred scheme, the antiviral composition comprises 10-20 parts of ningnanmycin and 1-10 parts of amino-oligosaccharin according to parts by weight.
In the above antiviral composition containing ningnanmycin and amino-oligosaccharin, as a preferred scheme, the antiviral composition comprises 15 parts of ningnanmycin and 6 parts of amino-oligosaccharin according to parts by weight.
In the above antiviral composition containing ningnanmycin and amino-oligosaccharin, as a preferred scheme, the antiviral composition comprises 1-10 parts of ningnanmycin and 10-20 parts of amino-oligosaccharin in parts by weight.
In the antiviral composition containing the ningnanmycin and the amino-oligosaccharin, as a preferable scheme, the antiviral composition comprises 6 parts of the ningnanmycin and 15 parts of the amino-oligosaccharin in weight parts, and the weight of the antiviral composition is 0.1-50% of the total weight of the dosage form.
The application also provides a soluble powder preparation, which comprises 50 parts of the antiviral composition, 20 parts of wetting agent, dispersing agent, white carbon black and/or filler, 2-10 parts of auxiliary agent comprising sodium dodecyl benzene sulfonate and filler comprising diatomite according to parts by weight.
The application also provides a soluble preparation which comprises 50 parts of the antiviral composition, 25-50 parts of ethylene glycol and/or cyclohexanone and the balance of water.
The application also provides a suspending agent preparation, which comprises 50 parts of the antiviral composition, 2-5 parts of ethylene glycol and/or cyclohexanone, 2-5 parts of mannitol and/or sorbitol, 1-2 parts of magnesium sulfate and the balance of water.
The application also provides a granular preparation, which comprises 50 parts of the antiviral composition, 10-15 parts of naphthalene sulfonic acid formaldehyde polycondensate, 2-5 parts of sodium dodecyl sulfate, 2-10 parts of ammonium sulfate and the balance of diatomite.
The application also provides the application of the antiviral composition, the soluble powder, the soluble solution, the suspending agent or the granules for preventing and treating tomato virus diseases.
Compared with the prior art, the application has the following technical effects:
1. the application provides an antiviral composition containing Ningnanmycin and amino-oligosaccharin, which has good control effect, low pesticide residue, stable pesticide effect and difficult resistance generation;
2. the application provides an antiviral composition containing Ningnanmycin and amino-oligosaccharin, which can delay the generation of drug resistance of viral diseases to medicaments and can prolong the service life of pesticide active ingredients.
The application also provides a preparation containing the antiviral composition and application thereof, and the preparation has the beneficial effects similar to those of the antiviral composition and is not repeated.
Detailed Description
Various exemplary embodiments of the application will now be described in detail, which should not be considered as limiting the application, but rather as more detailed descriptions of certain aspects, features and embodiments of the application.
It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. In addition, for numerical ranges in this disclosure, it is understood that each intermediate value between the upper and lower limits of the ranges is also specifically disclosed. Every smaller range between any stated value or stated range, and any other stated value or intermediate value within the stated range, is also encompassed within the application. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present application. All documents mentioned in this specification are incorporated by reference for the purpose of disclosing and describing the methods and/or materials associated with the documents. In case of conflict with any incorporated document, the present specification will control.
It will be apparent to those skilled in the art that various modifications and variations can be made in the specific embodiments of the application described herein without departing from the scope or spirit of the application. Other embodiments will be apparent to those skilled in the art from consideration of the specification of the present application. The specification and examples of the present application are exemplary only.
As used herein, the terms "comprising," "including," "having," "containing," and the like are intended to be inclusive and mean an inclusion, but not limited to.
Unless otherwise defined, the terms used in the present application and related to traditional Chinese medicine and traditional Chinese medicine are those known to those skilled in the art, such as moistening, etc.
The "parts" in the present application are all parts by mass unless otherwise specified.
The parts by weight of the present application mainly include the disclosed numerical range, any numerical value (including integers and fractions) or any two numerical value intervals in the disclosed range, or discontinuous plural intervals, and also include the numerical value or the numerical value range near the end of the numerical value range where the effect can be expected to be similar, for example, 5-10 parts, not only 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts and any two part intervals, but also other numerical value ranges are not included in the present application by way of example. Accordingly, the application also includes any subrange of any numerical range or any specific numerical value therein that has been directly disclosed.
The application provides an antiviral composition containing Ningnanmycin and amino-oligosaccharin, which comprises 1.0-30.0 parts (for example, 1 part, 3 parts, 4 parts, 6 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 24 parts, 30 parts and the like, the other parts can be taken as the decimal), 1.0-20.0 parts (for example, 1 part, 3 parts, 4 parts, 6 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts and the like, the other parts can be taken as the decimal), 2.0-10.0 parts (for example, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, the other parts can be taken as the decimal), 1.0-10.0 parts (1 part, for example, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts and the like) of nutmeg, the medicine composition is prepared from 1.0 to 10.0 parts (for example, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts and 10 parts, the decimal part can be obtained), 1.0 to 10.0 parts (for example, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts and 10 parts, the decimal part can be obtained) of the radix codonopsis pilosulae, 1.0 to 20.0 parts (for example, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 8 parts, 10 parts, 13 parts, 15 parts and 20 parts, etc., the decimal part can be obtained).
The application provides an antiviral composition containing ningnanmycin and amino-oligosaccharin, wherein the active ingredients of the antiviral composition comprise the ningnanmycin and the amino-oligosaccharin, and the mass ratio of the ningnanmycin to the amino-oligosaccharin is 1: (0.05-20).
In the above antiviral composition containing ningnanmycin and amino-oligosaccharin, preferably, the antiviral composition comprises 10-20 parts (for example, 10 parts, 13 parts, 15 parts, 20 parts, etc., preferably, decimal) of ningnanmycin and 1-10 parts (for example, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 8 parts, 10 parts, etc., preferably, decimal) of amino-oligosaccharin in terms of parts by weight.
In the above antiviral composition containing ningnanmycin and amino-oligosaccharin, preferably, the antiviral composition comprises 15 parts (for example, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 8 parts, 10 parts, 13 parts, 15 parts, etc., preferably, decimal) of ningnanmycin and 6 parts (for example, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, etc., preferably, decimal) of amino-oligosaccharin in parts by weight.
In the above antiviral composition containing ningnanmycin and amino-oligosaccharin, preferably, the antiviral composition comprises 1 to 10 parts (for example, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 8 parts, 10 parts, etc., preferably, decimal) of ningnanmycin and 10 to 20 parts (for example, 10 parts, 13 parts, 15 parts, 20 parts, etc., preferably, decimal) of amino-oligosaccharin in parts by weight.
In the above antiviral composition containing ningnanmycin and amino-oligosaccharin, preferably, the antiviral composition comprises 6 parts (for example, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, etc., preferably, decimal) of ningnanmycin and 15 parts (for example, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 8 parts, 10 parts, 13 parts, 15 parts, etc., preferably, decimal) of amino-oligosaccharin, accounting for 0.1% -50% of the total weight of the dosage form.
The application also provides a soluble powder preparation, which comprises 50 parts of the antiviral composition, 20 parts of wetting agent, dispersing agent, white carbon black and/or filler, 2-10 parts of auxiliary agent comprising sodium dodecyl benzene sulfonate and filler comprising diatomite according to parts by weight.
The application also provides a soluble preparation which comprises 50 parts of the antiviral composition, 25-50 parts of ethylene glycol and/or cyclohexanone and the balance of water.
The application also provides a suspending agent preparation, which comprises 50 parts of the antiviral composition, 2-5 parts of ethylene glycol and/or cyclohexanone, 2-5 parts of mannitol and/or sorbitol, 1-2 parts of magnesium sulfate and the balance of water.
The application also provides a granular preparation, which comprises 50 parts of the antiviral composition, 10-15 parts of naphthalene sulfonic acid formaldehyde polycondensate, 2-5 parts of sodium dodecyl sulfate, 2-10 parts of ammonium sulfate and the balance of diatomite.
The application also provides the application of the antiviral composition, the soluble powder, the soluble solution, the suspending agent or the granules for preventing and treating tomato virus diseases.
The above embodiments are only illustrative of the preferred embodiments of the present application and are not intended to limit the scope of the present application, and various modifications and improvements made by those skilled in the art to the technical solutions of the present application should fall within the protection scope defined by the claims of the present application without departing from the design spirit of the present application.
Claims (10)
1. An antiviral composition containing ningnanmycin and amino-oligosaccharin, which is characterized in that the active ingredients of the antiviral composition comprise the ningnanmycin and the amino-oligosaccharin, and the mass ratio of the ningnanmycin to the amino-oligosaccharin is 1: (0.05-20).
2. The antiviral composition containing ningnanmycin and amino-oligosaccharin according to claim 1, wherein the antiviral composition comprises, by weight, 10-20 parts of ningnanmycin and 1-10 parts of amino-oligosaccharin.
3. An antiviral composition comprising ningnanmycin and amino-oligosaccharin according to claim 2, wherein the antiviral composition comprises 15 parts of ningnanmycin and 6 parts of amino-oligosaccharin in parts by weight.
4. The antiviral composition containing ningnanmycin and amino-oligosaccharin according to claim 1, wherein the antiviral composition comprises, by weight, 1-10 parts of ningnanmycin and 10-20 parts of amino-oligosaccharin.
5. The antiviral composition comprising ningnanmycin and amino-oligosaccharin according to claim 4, wherein the antiviral composition comprises 6 parts by weight of ningnanmycin and 15 parts by weight of amino-oligosaccharin, and the weight of the antiviral composition is 0.1% -50% of the total weight of the dosage form.
6. A soluble powder preparation, which is characterized by comprising 50 parts of the antiviral composition according to any one of claims 1 to 5, 20 parts of wetting agent, dispersing agent, white carbon black and/or filler, 2-10 parts of sodium dodecyl benzene sulfonate and 2-10 parts of filler.
7. A soluble formulation comprising 50 parts of an antiviral composition according to any one of claims 1 to 5, and further comprising 25 to 50 parts of ethylene glycol and/or cyclohexanone, the balance being water.
8. A suspension formulation comprising 50 parts of an antiviral composition according to any one of claims 1 to 5, further comprising 2 to 5 parts of ethylene glycol and/or cyclohexanone, 2 to 5 parts of mannitol and/or sorbitol, 1 to 2 parts of magnesium sulphate and the balance water.
9. A granule formulation comprising 50 parts of the antiviral composition according to any one of claims 1 to 5, and further comprising 10 to 15 parts of naphthalene sulfonic acid formaldehyde polycondensate, 2 to 5 parts of sodium dodecyl sulfate, 2 to 10 parts of ammonium sulfate, and the balance of diatomaceous earth.
10. Use of an antiviral composition according to any one of claims 1 to 5 or a soluble powder according to claim 6 or a soluble solution according to claim 7 or a suspension according to claim 8 or a granule according to claim 9 for the control of tomato viral diseases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310690889.XA CN116636536A (en) | 2023-06-12 | 2023-06-12 | Antiviral composition containing ningnanmycin and amino-oligosaccharin, preparation and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310690889.XA CN116636536A (en) | 2023-06-12 | 2023-06-12 | Antiviral composition containing ningnanmycin and amino-oligosaccharin, preparation and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116636536A true CN116636536A (en) | 2023-08-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310690889.XA Withdrawn CN116636536A (en) | 2023-06-12 | 2023-06-12 | Antiviral composition containing ningnanmycin and amino-oligosaccharin, preparation and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116636536A (en) |
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2023
- 2023-06-12 CN CN202310690889.XA patent/CN116636536A/en not_active Withdrawn
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