CN116616306A - 抑菌材料及使用其的呼吸湿化仪吸氧管 - Google Patents

抑菌材料及使用其的呼吸湿化仪吸氧管 Download PDF

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CN116616306A
CN116616306A CN202310522279.9A CN202310522279A CN116616306A CN 116616306 A CN116616306 A CN 116616306A CN 202310522279 A CN202310522279 A CN 202310522279A CN 116616306 A CN116616306 A CN 116616306A
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guanylated
respiratory humidifier
bacteriostatic material
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黄海生
王利明
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Zhejiang Haisheng Medical Equipment Co ltd
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Abstract

公开了一种抑菌材料，包括聚己双胍、胍基化聚合物和羟基羧酸。此外，还公开了一种抑菌材料溶液，呼吸湿化仪PVC吸氧管的抑菌处理方法，以及呼吸湿化仪PVC吸氧管。本发明使用特定组成的抑菌材料，经过抑菌处理得到呼吸湿化仪PVC吸氧管。相对于现有技术，所述呼吸湿化仪PVC吸氧管针对金黄色葡萄球菌和大肠杆菌的抑菌性能更好。

Description

抑菌材料及使用其的呼吸湿化仪吸氧管
技术领域
本发明属于医疗器械技术领域，具体涉及一种抑菌材料及使用其的呼吸湿化仪吸氧管。
背景技术
高流量呼吸湿化治疗仪，是指通过高流量专用鼻塞或其他患者接口，持续为患者提供可以调控并相对恒定吸氧浓度(21％～100％)、温度(31-37℃)和湿度的高流量(8～80L/min)吸入气体的治疗方式。相对于无创呼吸机，其显著优势在于舒适性及耐受性、依从性。对于轻中度的低氧血症的患者，首选推荐高流量呼吸湿化治疗仪进行治疗。
与普通氧疗类似，高流量呼吸湿化治疗仪同样将蒸馏水加入氧气湿化瓶湿化，然后在连接流量表与吸氧管，但其改善氧合的作用更好。但诸多开放操作如湿化液的灌注、湿化瓶的存放等均有可能导致吸氧装置尤其是PVC材质的吸氧管产生污染，从而导致患者容易感染。
因此，迫切需要针对现有技术的上述缺陷，提供一种抑菌性更好的呼吸湿化仪PVC吸氧管。
发明内容
本发明的目的在于提供一种抑菌性更好的呼吸湿化仪PVC吸氧管。
为实现发明目的，一方面，本发明采用以下技术方案：一种抑菌材料，包括聚己双胍、胍基化聚合物和羟基羧酸。
根据本发明所述的抑菌材料，其中，所述胍基化聚合物选自胍基化聚乙烯亚胺。
根据本发明所述的抑菌材料，其中，所述胍基化聚乙烯亚胺的重均分子量Mw＝(1.5-2)×104，数均分子量Mn＝(8-10)×103，多分散性指数PDI＝1.6-2.2。
在一个具体的实施方式中，所述胍基化聚乙烯亚胺的重均分子量Mw＝1.75×104，数均分子量Mn＝9.3×103，多分散性指数PDI＝1.9。
根据本发明所述的抑菌材料，其中，所述羟基羧酸选自酒石酸。
根据本发明所述的抑菌材料，其中，聚己双胍、胍基化聚合物和羟基羧酸的重量比为(3-5):(1-3):(3-5)。
在一个具体的实施方式中，聚己双胍、胍基化聚合物和羟基羧酸的重量比为4:2:4。
另一方面，本发明提供了一种抑菌材料溶液，由上下文所述的抑菌材料和无水乙醇组成。
根据本发明所述的抑菌材料溶液，其中，上下文所述的抑菌材料浓度为(0.5-4)％g/mL。
在一个具体的实施方式中，上下文所述的抑菌材料浓度为2％g/mL。
又一方面，本发明提供了一种呼吸湿化仪PVC吸氧管的抑菌处理方法，包括：将PVC吸氧管浸没在上下文所述的抑菌材料溶液中，持续一定时间。
根据本发明所述的抑菌处理方法，其中，所述时间为1-10min。
在一个具体的实施方式中，所述时间为5min。
最后一方面，本发明提供了一种呼吸湿化仪PVC吸氧管，包括本体和抑菌层；其中，抑菌层由上下文所述的抑菌处理方法得到。
发明人发现，使用特定组成的抑菌材料，经过抑菌处理得到呼吸湿化仪PVC吸氧管。相对于现有技术，所述呼吸湿化仪PVC吸氧管针对金黄色葡萄球菌和大肠杆菌的抑菌性能更好。
具体实施方式
下面结合具体实施方式，进一步阐述本发明。
应理解，本发明的具体实施方式仅用于阐释本发明的精神和原则，而不用于限制本发明的范围。此外应理解，在阅读了本发明的内容之后，本领域技术人员可以对本发明的技术方案作出各种改动、替换、删减、修正或调整，这些等价技术方案同样落于本发明权利要求书所限定的范围。
在本发明中，如无其它说明，所有份数均为重量份；所有百分比均为重量百分比。
实施例1
将聚乙烯亚胺(数均分子量Mn＝600)和盐酸胍按照1.3:1质量比加入到烧瓶中，在氮气气氛和搅拌条件下，升温至90℃，反应2h；继续升温至160℃，反应4h；使用稀盐酸吸收反应过程的副产物氨气。反应结束，得到淡黄色黏稠液体，冷却至室温，干燥得到胍基聚乙烯亚胺产品。胍基化聚乙烯亚胺的重均分子量Mw＝1.75×104，数均分子量Mn＝9.3×103，多分散性指数PDI＝1.9。
实施例2
按照配方，将8g聚己双胍(PAPB)、4g胍基化聚乙烯亚胺和8g混旋酒石酸溶解于1L乙醇中，得到抑菌材料溶液。
实施例3
将PVC吸氧管在无水乙醇中超声清洗30min。室温干燥后，在实施例2的抑菌材料溶液中浸泡5min。室温干燥，并用超纯水清洗3次。
比较例1
按照配方，将10g聚己双胍(PAPB)和10g酒石酸溶解于1L乙醇中，得到抑菌材料溶液。
将PVC吸氧管在无水乙醇中超声清洗30min。室温干燥后，在抑菌材料溶液中浸泡5min。室温干燥，并用超纯水清洗3次。
抑菌性能测试
金黄色葡萄球菌(ATCC 6538)和大肠杆菌(ATCC 25922)分别接种在LB固体培养基上，37℃孵化24h。选用单克隆菌株转移到25mL液体培养基，在恒温摇床上振荡培养12h。将含细菌的液体培基在3000rmp转速下离心10min，去除上层清液，用LB培养液将细菌浓度调整到1×106CFU/mL。
采用JIS Z 2801标准对样品中的活细菌数进行统计。将实施例3和比较例1的PVC吸氧管样品置于12孔板中，在表面中心区域加入25μL上述细菌悬浮液，并用PE膜(1×1cm)覆盖，使细菌液均匀的铺展在PVC吸氧管表面，37℃条件下孵化24h，随后加入3mL PBS溶液超声2min以使细菌在表面脱粘附，含细菌的PBS溶液按一定倍数稀释，并涂于固体培养基上。37℃过夜培养后，对固体培养基表面形成的细菌菌落进行计数统计。
结果如表1所示。
表1
样品 金黄色葡萄球菌 大肠杆菌
实施例3 98.2％ 99.3％
比较例1 51.6％ 67.5％
以上所述仅为本发明的优选实施例而已，并不用于限制本发明，对于本领域的技术人员来说，本发明可以有各种更改和变化。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均包含在本发明的保护范围之内。

Claims (10)

1.一种抑菌材料，其特征在于，包括聚己双胍、胍基化聚合物和羟基羧酸。
2.根据权利要求1所述的抑菌材料，其中，所述胍基化聚合物选自胍基化聚乙烯亚胺。
3.根据权利要求2所述的抑菌材料，其中，所述胍基化聚乙烯亚胺的重均分子量Mw＝(1.5-2)×104，数均分子量Mn＝(8-10)×103，多分散性指数PDI＝1.6-2.2。
4.根据权利要求1所述的抑菌材料，其中，所述羟基羧酸选自酒石酸。
5.根据权利要求1所述的抑菌材料，其中，聚己双胍、胍基化聚合物和羟基羧酸的重量比为(3-5):(1-3):(3-5)。
6.一种抑菌材料溶液，其特征在于，由根据权利要求1-5任一项所述的抑菌材料和无水乙醇组成。
7.根据权利要求6所述的抑菌材料溶液，其中，上下文所述的抑菌材料浓度为(0.5-4)％g/mL。
8.一种呼吸湿化仪PVC吸氧管的抑菌处理方法，包括：
将PVC吸氧管浸没在根据权利要求6或7所述的抑菌材料溶液中，持续一定时间。
9.根据权利要求8所述的抑菌处理方法，其中，所述时间为1-10min。
10.一种呼吸湿化仪PVC吸氧管，包括本体和抑菌层；其特征在于，抑菌层由根据权利要求8或9所述的抑菌处理方法得到。
CN202310522279.9A 2023-05-10 2023-05-10 抑菌材料及使用其的呼吸湿化仪吸氧管 Pending CN116616306A (zh)

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