CN116615235A - 融合前稳定的hmpv f蛋白 - Google Patents

融合前稳定的hmpv f蛋白 Download PDF

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Publication number
CN116615235A
CN116615235A CN202180075353.6A CN202180075353A CN116615235A CN 116615235 A CN116615235 A CN 116615235A CN 202180075353 A CN202180075353 A CN 202180075353A CN 116615235 A CN116615235 A CN 116615235A
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CN
China
Prior art keywords
engineered
protein
val
engineered protein
ala
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Pending
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CN202180075353.6A
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English (en)
Chinese (zh)
Inventor
贾森·麦克莱伦
谢庆林
斯科特·鲁什
王念双
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University of Texas System
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University of Texas System
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Publication of CN116615235A publication Critical patent/CN116615235A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18311—Metapneumovirus, e.g. avian pneumovirus
    • C12N2760/18322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18311—Metapneumovirus, e.g. avian pneumovirus
    • C12N2760/18334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202180075353.6A 2020-10-09 2021-10-07 融合前稳定的hmpv f蛋白 Pending CN116615235A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063089978P 2020-10-09 2020-10-09
US63/089,978 2020-10-09
PCT/US2021/053944 WO2022076669A1 (en) 2020-10-09 2021-10-07 Prefusion-stabilized hmpv f proteins

Publications (1)

Publication Number Publication Date
CN116615235A true CN116615235A (zh) 2023-08-18

Family

ID=81125547

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180075353.6A Pending CN116615235A (zh) 2020-10-09 2021-10-07 融合前稳定的hmpv f蛋白

Country Status (13)

Country Link
US (4) US11919927B2 (https=)
EP (1) EP4225364A4 (https=)
JP (2) JP7660671B2 (https=)
KR (3) KR102860080B1 (https=)
CN (1) CN116615235A (https=)
AU (2) AU2021357826A1 (https=)
CA (1) CA3195015A1 (https=)
CO (1) CO2023005373A2 (https=)
IL (3) IL320367A (https=)
MX (1) MX2023004078A (https=)
NZ (1) NZ798475A (https=)
PE (1) PE20231439A1 (https=)
WO (1) WO2022076669A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025119162A1 (zh) * 2023-12-04 2025-06-12 深圳深信生物科技有限公司 偏肺病毒(mpv)疫苗
WO2025260634A1 (zh) * 2024-06-19 2025-12-26 厦门万泰沧海生物技术有限公司 Rsv和hmpv融合f蛋白及其用途

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AU2021380755A1 (en) 2020-11-13 2023-06-22 Icosavax, Inc. Protein-based nanoparticle vaccine for metapneumovirus
EP4448802A1 (en) * 2021-12-16 2024-10-23 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion hmpv fusion proteins
KR20250010642A (ko) * 2022-05-12 2025-01-21 엠에스디 인터내셔널 비즈니스 게엠베하 안정화된 융합-전 hmpv 융합 단백질
EP4578878A4 (en) * 2022-09-29 2026-03-18 Beijing Benewill Tech Development Co Ltd RECOMBINANT FUSION PROTEIN OF RESPIRATORY SYNCYTIAL VIRUS HAVING A PRE-FUSION CONFORMATION, ITS PREPARATION PROCESS AND ITS USE
US20240252614A1 (en) 2023-01-18 2024-08-01 Pfizer Inc. Vaccines against respiratory diseases
US12319747B2 (en) 2023-07-03 2025-06-03 Medicovestor, Inc. Methods of using anti-SP17 immunotherapeutics
US12364777B2 (en) 2023-10-20 2025-07-22 Medicovestor, Inc. Homodimeric antibodies for use in treating cancers and methods of use
WO2025126071A1 (en) 2023-12-14 2025-06-19 Pfizer Inc. Rna molecules
US12116410B1 (en) 2023-12-26 2024-10-15 Medicovestor, Inc. Methods of manufacturing dimeric antibodies
US12600795B2 (en) 2023-12-26 2026-04-14 Medicovestor, Inc. Oligomeric IgG for immunotherapeutics and diagnostics
WO2025144636A1 (en) * 2023-12-26 2025-07-03 The Scripps Research Institute ENGINEERED hMPV F PROTEIN IMMUNOGENS AND RELATED VACCINES
WO2025144914A1 (en) * 2023-12-26 2025-07-03 Medicovestor, Inc. Dimeric antibodies and their methods of manufacture
WO2025163460A2 (en) 2024-01-30 2025-08-07 Pfizer Inc. Vaccines against respiratory diseases
WO2026018181A1 (en) 2024-07-17 2026-01-22 Pfizer Inc. Immunogenic compositions and uses thereof
WO2026033492A1 (en) * 2024-08-08 2026-02-12 Vicebio Limited Chimeric fusion proteins as human metapneumovirus (hmpv) vaccines

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025119162A1 (zh) * 2023-12-04 2025-06-12 深圳深信生物科技有限公司 偏肺病毒(mpv)疫苗
WO2025260634A1 (zh) * 2024-06-19 2025-12-26 厦门万泰沧海生物技术有限公司 Rsv和hmpv融合f蛋白及其用途

Also Published As

Publication number Publication date
IL301950A (en) 2023-06-01
JP2025102893A (ja) 2025-07-08
JP2023544834A (ja) 2023-10-25
KR20250140124A (ko) 2025-09-24
IL301950B2 (en) 2025-09-01
IL320367A (en) 2025-06-01
US20240140994A1 (en) 2024-05-02
US20230357327A1 (en) 2023-11-09
WO2022076669A1 (en) 2022-04-14
KR102860080B1 (ko) 2025-09-15
AU2021357826A9 (en) 2023-07-13
KR20230084201A (ko) 2023-06-12
AU2021357826A1 (en) 2023-05-11
IL301950B1 (en) 2025-05-01
MX2023004078A (es) 2023-05-24
JP7660671B2 (ja) 2025-04-11
EP4225364A1 (en) 2023-08-16
IL321500A (en) 2025-08-01
PE20231439A1 (es) 2023-09-14
US12304930B2 (en) 2025-05-20
NZ798475A (en) 2026-03-27
US12077563B2 (en) 2024-09-03
CO2023005373A2 (es) 2023-05-19
US20250257102A1 (en) 2025-08-14
CA3195015A1 (en) 2022-04-14
US11919927B2 (en) 2024-03-05
EP4225364A4 (en) 2025-02-26
US20240376158A1 (en) 2024-11-14
AU2025208554A1 (en) 2025-08-21
KR20250139413A (ko) 2025-09-23

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