MX2022015593A - Metodo de ensamblaje de particulas similares a virus de dos componentes. - Google Patents
Metodo de ensamblaje de particulas similares a virus de dos componentes.Info
- Publication number
- MX2022015593A MX2022015593A MX2022015593A MX2022015593A MX2022015593A MX 2022015593 A MX2022015593 A MX 2022015593A MX 2022015593 A MX2022015593 A MX 2022015593A MX 2022015593 A MX2022015593 A MX 2022015593A MX 2022015593 A MX2022015593 A MX 2022015593A
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- compb
- compa
- inlet fluid
- fluid stream
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000002245 particle Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 9
- 108090000623 proteins and genes Proteins 0.000 abstract 9
- 239000012530 fluid Substances 0.000 abstract 4
- 239000002086 nanomaterial Substances 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18523—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Analytical Chemistry (AREA)
Abstract
En la presente se divulgan métodos para elaborar una nanoestructura, que comprende agregar una proteína de componente A (compA) a una solución que comprende una proteína de componente B (compB) en condiciones que minimizan la tensión de cizallamiento, que forma así un complejo compA:compB. Adicionalmente, se divulgan métodos para elaborar una nanoestructura, que comprende (i) proporcionar una primera corriente de fluido de entrada que comprende una primera proteína y una segunda corriente de fluido de entrada que comprende una segunda proteína, y (ii) poner en contacto la primera corriente de fluido de entrada y la segunda corriente de fluido de entrada para formar una corriente de salida, en donde la mezcla de la primera proteína y la segunda proteína se produce en la corriente de salida, que forma así un complejo de proteínas comprende la primera proteína y la segunda proteína. Se puede utilizar un mezclador microfluídico. Los métodos pueden comprender además purificar el complejo compA:compB del exceso de compA, exceso de compB y/u otras impurezas al filtrar la solución con una membrana de 1,000 kDa o un equivalente de esta.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063036505P | 2020-06-09 | 2020-06-09 | |
| PCT/US2021/036689 WO2021252688A1 (en) | 2020-06-09 | 2021-06-09 | Method of assemblying two-component virus-like particle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022015593A true MX2022015593A (es) | 2023-04-03 |
Family
ID=78846601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022015593A MX2022015593A (es) | 2020-06-09 | 2021-06-09 | Metodo de ensamblaje de particulas similares a virus de dos componentes. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230227790A1 (es) |
| EP (1) | EP4161949A1 (es) |
| JP (1) | JP2023530635A (es) |
| KR (1) | KR20230038465A (es) |
| CN (1) | CN116234567A (es) |
| AU (1) | AU2021289470A1 (es) |
| CA (1) | CA3182021A1 (es) |
| MX (1) | MX2022015593A (es) |
| WO (1) | WO2021252688A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023225562A1 (en) * | 2022-05-17 | 2023-11-23 | Icosavax, Inc. | Multivalent vaccine for paramyxoviruses and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140335148A1 (en) * | 2013-05-07 | 2014-11-13 | Ho-Wang Tong | Bioactive substance-containing nanofibers and uses thereof |
| EP3481539A4 (en) * | 2016-07-06 | 2020-02-26 | Precision Nanosystems Inc | INTELLIGENT MICROFLUIDIC MIXING INSTRUMENT AND CARTRIDGES |
| CA3058794A1 (en) * | 2017-04-04 | 2018-10-11 | University Of Washington | Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use |
-
2021
- 2021-06-09 WO PCT/US2021/036689 patent/WO2021252688A1/en unknown
- 2021-06-09 CN CN202180045756.6A patent/CN116234567A/zh active Pending
- 2021-06-09 EP EP21821883.2A patent/EP4161949A1/en active Pending
- 2021-06-09 JP JP2022576127A patent/JP2023530635A/ja active Pending
- 2021-06-09 CA CA3182021A patent/CA3182021A1/en active Pending
- 2021-06-09 KR KR1020237000836A patent/KR20230038465A/ko active Search and Examination
- 2021-06-09 AU AU2021289470A patent/AU2021289470A1/en active Pending
- 2021-06-09 US US18/000,566 patent/US20230227790A1/en active Pending
- 2021-06-09 MX MX2022015593A patent/MX2022015593A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021289470A1 (en) | 2023-01-19 |
| CA3182021A1 (en) | 2021-12-16 |
| WO2021252688A1 (en) | 2021-12-16 |
| CN116234567A (zh) | 2023-06-06 |
| KR20230038465A (ko) | 2023-03-20 |
| JP2023530635A (ja) | 2023-07-19 |
| US20230227790A1 (en) | 2023-07-20 |
| EP4161949A1 (en) | 2023-04-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kuntaegowdanahalli et al. | Inertial microfluidics for continuous particle separation in spiral microchannels | |
| Arunkumar et al. | Negatively charged tangential flow ultrafiltration membranes for whey protein concentration | |
| MX2022015593A (es) | Metodo de ensamblaje de particulas similares a virus de dos componentes. | |
| Ng et al. | Membrane fouling mechanisms during ultrafiltration of skimmed coconut milk | |
| ATE489178T1 (de) | System und verfahren zur behandlung von flugasche | |
| WO2007128795A3 (en) | Method for separation | |
| DE17203101T1 (de) | Fraktionierungsverfahren von löslichen Substanzen von Erbsen | |
| AU2015312506B2 (en) | Flocculation | |
| AU2016276972A8 (en) | Methods and systems for extracting protein and carbohydrate rich products from a microcrop and compositions thereof | |
| DE602004025773D1 (de) | Verfahren zur Verarbeitung von Fleisch | |
| WO2008156124A1 (ja) | 免疫グロブリン１量体の分離方法 | |
| PH12019500446A1 (en) | Epoxy emulsion and preparation method therefor | |
| MX2021000866A (es) | Sistemas y metodos para la filtracion de flujo tangencial de composiciones viscosas. | |
| ATE405591T1 (de) | Kontinuierliches verfahren zur anordnung von makromolekulären substanzen und die anschliessende aufnahme und isolierung einer makromolekulären anordnung, sowie ein für dieses verfahren geeignetes system | |
| Nor et al. | Performance of a two-stage membrane system for bromelain separation from pineapple waste mixture as impacted by enzymatic pretreatment and diafiltration | |
| Schroën et al. | Microtechnological tools to achieve sustainable food processes, products, and ingredients | |
| Li et al. | Protein recovery and anti-nutritional factor removal from soybean wastewater by complexing with a high concentration of polysaccharides in a novel quick-shearing system | |
| EP3161136B1 (de) | Verfahren zur anreicherung von mikrovesikeln | |
| EP2242339A3 (de) | Gasinjektionssystem und Verfahren zum Betrieb eines Gasinjektionssystems, insbesondere für eine Partikeltherapieanlage | |
| DE102012205372A1 (de) | Glutaminreiche Peptide als Luftporenbildner in Baustoffmassen | |
| Szerencsés et al. | Effect of vibration on the efficiency of ultrafiltration | |
| Yiengveerachon et al. | Characteristics of coconut protein separation process by means of membrane ultrafiltration | |
| NO20064143L (no) | Fremgangsmate for bearbeiding av flytende substanser | |
| Md Saleh et al. | Performance of single and two-stage cross-flow ultrafiltration membrane in fractionation of peptide from microalgae protein hydrolysate (Nannochloropsis gaditana) | |
| EP2587148A3 (de) | Sekundärbrennkammer mit Sekundärlufteindüsung |