MX2022015593A - Metodo de ensamblaje de particulas similares a virus de dos componentes. - Google Patents
Metodo de ensamblaje de particulas similares a virus de dos componentes.Info
- Publication number
- MX2022015593A MX2022015593A MX2022015593A MX2022015593A MX2022015593A MX 2022015593 A MX2022015593 A MX 2022015593A MX 2022015593 A MX2022015593 A MX 2022015593A MX 2022015593 A MX2022015593 A MX 2022015593A MX 2022015593 A MX2022015593 A MX 2022015593A
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- compb
- compa
- inlet fluid
- fluid stream
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000002245 particle Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 9
- 108090000623 proteins and genes Proteins 0.000 abstract 9
- 239000012530 fluid Substances 0.000 abstract 4
- 239000002086 nanomaterial Substances 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18523—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Analytical Chemistry (AREA)
Abstract
En la presente se divulgan métodos para elaborar una nanoestructura, que comprende agregar una proteína de componente A (compA) a una solución que comprende una proteína de componente B (compB) en condiciones que minimizan la tensión de cizallamiento, que forma así un complejo compA:compB. Adicionalmente, se divulgan métodos para elaborar una nanoestructura, que comprende (i) proporcionar una primera corriente de fluido de entrada que comprende una primera proteína y una segunda corriente de fluido de entrada que comprende una segunda proteína, y (ii) poner en contacto la primera corriente de fluido de entrada y la segunda corriente de fluido de entrada para formar una corriente de salida, en donde la mezcla de la primera proteína y la segunda proteína se produce en la corriente de salida, que forma así un complejo de proteínas comprende la primera proteína y la segunda proteína. Se puede utilizar un mezclador microfluídico. Los métodos pueden comprender además purificar el complejo compA:compB del exceso de compA, exceso de compB y/u otras impurezas al filtrar la solución con una membrana de 1,000 kDa o un equivalente de esta.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063036505P | 2020-06-09 | 2020-06-09 | |
| PCT/US2021/036689 WO2021252688A1 (en) | 2020-06-09 | 2021-06-09 | Method of assemblying two-component virus-like particle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022015593A true MX2022015593A (es) | 2023-04-03 |
Family
ID=78846601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022015593A MX2022015593A (es) | 2020-06-09 | 2021-06-09 | Metodo de ensamblaje de particulas similares a virus de dos componentes. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230227790A1 (es) |
| EP (1) | EP4161949A1 (es) |
| JP (1) | JP2023530635A (es) |
| KR (1) | KR20230038465A (es) |
| CN (1) | CN116234567A (es) |
| AU (1) | AU2021289470A1 (es) |
| CA (1) | CA3182021A1 (es) |
| MX (1) | MX2022015593A (es) |
| WO (1) | WO2021252688A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023225562A1 (en) * | 2022-05-17 | 2023-11-23 | Icosavax, Inc. | Multivalent vaccine for paramyxoviruses and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140335148A1 (en) * | 2013-05-07 | 2014-11-13 | Ho-Wang Tong | Bioactive substance-containing nanofibers and uses thereof |
| WO2018006166A1 (en) * | 2016-07-06 | 2018-01-11 | Precision Nanosystems Inc | Smart microfluidic mixing instrument and cartridges |
| JP7168938B2 (ja) * | 2017-04-04 | 2022-11-10 | ユニヴァーシティ オブ ワシントン | パラミクソウイルスおよび／またはニューモウイルスのｆタンパク質を表示する自己アセンブリするタンパク質ナノ構造およびその使用 |
-
2021
- 2021-06-09 CA CA3182021A patent/CA3182021A1/en active Pending
- 2021-06-09 AU AU2021289470A patent/AU2021289470A1/en active Pending
- 2021-06-09 WO PCT/US2021/036689 patent/WO2021252688A1/en unknown
- 2021-06-09 KR KR1020237000836A patent/KR20230038465A/ko unknown
- 2021-06-09 CN CN202180045756.6A patent/CN116234567A/zh active Pending
- 2021-06-09 US US18/000,566 patent/US20230227790A1/en active Pending
- 2021-06-09 EP EP21821883.2A patent/EP4161949A1/en active Pending
- 2021-06-09 MX MX2022015593A patent/MX2022015593A/es unknown
- 2021-06-09 JP JP2022576127A patent/JP2023530635A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021252688A1 (en) | 2021-12-16 |
| JP2023530635A (ja) | 2023-07-19 |
| AU2021289470A1 (en) | 2023-01-19 |
| CN116234567A (zh) | 2023-06-06 |
| EP4161949A1 (en) | 2023-04-12 |
| US20230227790A1 (en) | 2023-07-20 |
| KR20230038465A (ko) | 2023-03-20 |
| CA3182021A1 (en) | 2021-12-16 |
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