CN116585416B - 一种治疗稳定性心绞痛的中药组合物及其制备方法 - Google Patents
一种治疗稳定性心绞痛的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明涉及中药组合与技术领域,尤其涉及一种治疗稳定性心绞痛的中药组合物及其制备方法。本发明提供了一种治疗稳定性心绞痛的中药组合物,由包括如下质量份数的组分制备而成:黄芪25~35份、丹参25~35份、瓜蒌10~20份、黄连10~20份、三七2~4份、玄参10~20份、浙贝母25~35份、虎杖25~35份、桃仁10~14份、牡蛎25~35份、茯苓8~12份、白前5~15份和桑叶7~11份。本发明所提供的组合物具有优异的预防和治疗稳定性心绞痛的作用,具有疗效好、无副作用等特点,其使用效果与现有技术药物相当。
Description
技术领域
本发明涉及中药组合物技术领域,尤其涉及一种治疗稳定性心绞痛的中药组合物及其制备方法。
背景技术
冠状动脉粥样硬化性心脏病是冠状动脉血管发生动脉粥样硬化病变而引起血管腔狭窄或阻塞,造成心肌缺血、缺氧或坏死而导致的心脏病,常常被称为“冠心病”。但是冠心病的范围可能更广泛,还包括炎症、栓塞等导致管腔狭窄或闭塞。世界卫生组织将冠心病分为5大类:无症状心肌缺血(隐匿性冠心病)、冠心病、心肌梗死、缺血性心力衰竭(缺血性心脏病)和猝死5种临床类型。临床中常常分为稳定性冠心病和急性冠状动脉综合征。
药物治疗是冠心病病情控制的基础。例如,抗血小板治疗,主要是抗血小板凝聚,防止血栓的形成。常用药物为阿司匹林,是抗血小板治疗的基石,除非有禁忌症,否则所有患者均应长期口服阿司匹林进行治疗。阿司匹林不耐受患者,可考虑使用吲哚布芬。还可服用抗心肌缺血药物主要用于减少心肌耗氧量、扩张冠状动脉,增加冠脉血流,缓解心肌缺血。例如硝酸酯类药物。对于需要冠脉血运重建的患者,则需要进行手术治疗,包括经皮冠脉介入治疗(PC)和冠脉旁路移植术(CABG)。以上方法治疗冠心病,化学药物治疗服药时间长,手术治疗风险大,且费用高。
因此,如何提供一种治疗冠心病,尤其是可以有效治疗稳定性心绞痛的中药组合物,以解决现有技术中缺乏有关治疗稳定性心绞痛中药制剂的技术问题,是本领域技术人员亟需解决的问题。
发明内容
本发明的目的在于提供一种治疗稳定性心绞痛的中药组合物及其制备方法。
为了实现上述发明目的,本发明提供以下技术方案:
本发明提供了一种治疗稳定性心绞痛的中药组合物,由包括如下质量份数的组分制备而成:黄芪25~35份、丹参25~35份、瓜蒌10~20份、黄连10~20份、三七2~4份、玄参10~20份、浙贝母25~35份、虎杖25~35份、桃仁10~14份、牡蛎25~35份、茯苓8~12份、白前5~15份和桑叶7~11份。
本发明还提供了所述的一种治疗稳定性心绞痛的中药组合物的制备方法,包括如下步骤:
(1)将黄芪、丹参、瓜蒌、黄连、三七、玄参、浙贝母、虎杖、桃仁、牡蛎、茯苓、白前和桑叶混合,得物料1,将物料1与水混合浸提,过滤得浸提液和滤渣1;
(2)将滤渣1与水混合煎煮,过滤得滤液;
(3)将所述浸提液与滤液混合减压浓缩得浸膏、干燥即得治疗稳定性心绞痛的中药组合物。
优选的,步骤(1)所述物料1与水的质量比为1:3~5。
优选的,步骤(1)所述浸提的时间为1.5~2.5h;所述浸提的温度为55~65℃。
优选的,步骤(2)所述滤渣1与水的质量比为1:2~4。
优选的,步骤(2)所述煎煮的时间为2.5~3.5h。
优选的,步骤(3)减压浓缩至55℃时相对密度为1.10~1.20的浸膏。
优选的,步骤(3)所述干燥的温度为50~60℃。
优选的,步骤(3)所述干燥的时间为3.5~4.5h。
与现有技术相比,本发明具有如下的有益效果:
1、本发明提供的组方,以黄芪为君,甘温补气以治其本,气旺则血行;丹参、三七皆可活血化瘀,与黄芪合用可起到益气活血、祛瘀止痛之效,同时可以防止温补太过而损耗正气;黄连、瓜蒌亦为臣药,性寒味苦,可清热解毒;桑叶疏散风热、平肝明目、清肺润燥,玄参清热滋阴,凉血散结,牡蛎软坚散结,白前、浙贝母可清热降气,茯苓化饮利水,诸药合用而为佐,可养阴除热;桃仁、虎杖为使,可逐瘀通经、通络止痛而增强化瘀消癥之力。全方配伍得当,诸药相合,共奏益气活血,祛瘀通络之效,标本兼顾,致使有形之邪消散,心脉通畅,血行无虞,通则不痛。
2、本发明所提供的组合物具有优异的预防和治疗稳定性心绞痛的作用,具有疗效好、无副作用等特点,其使用效果与现有技术药物相当。
具体实施方式
本发明提供了一种治疗稳定性心绞痛的中药组合物,由包括如下质量份数的组分制备而成:黄芪25~35份、丹参25~35份、瓜蒌10~20份、黄连10~20份、三七2~4份、玄参10~20份、浙贝母25~35份、虎杖25~35份、桃仁10~14份、牡蛎25~35份、茯苓8~12份、白前5~15份和桑叶7~11份;
优选由包括如下质量份数的组分制备而成:黄芪27~33份、丹参27~33份、瓜蒌12~18份、黄连12~18份、三七3份、玄参12~18份、浙贝母27~33份、虎杖27~33份、桃仁11~13份、牡蛎27~33份、茯苓9~11份、白前7~13份和桑叶8~10份;
进一步优选由包括如下质量份数的组分制备而成:黄芪29~31份、丹参29~31份、瓜蒌13~17份、黄连13~17份、三七3份、玄参13~17份、浙贝母29~31份、虎杖29~31份、桃仁12份、牡蛎29~31份、茯苓10份、白前8~12份和桑叶9份;
更优选由包括如下质量份数的组分制备而成:黄芪30份、丹参30份、瓜蒌15份、黄连15份、三七3份、玄参15份、浙贝母30份、虎杖30份、桃仁12份、牡蛎30份、茯苓10份、白前10份和桑叶9份。
本发明还提供了所述的一种治疗稳定性心绞痛的中药组合物的制备方法,包括如下步骤:
(1)将黄芪、丹参、瓜蒌、黄连、三七、玄参、浙贝母、虎杖、桃仁、牡蛎、茯苓、白前和桑叶混合,得物料1,将物料1与水混合浸提,过滤得浸提液和滤渣1;
(2)将滤渣1与水混合煎煮,过滤得滤液;
(3)将所述浸提液与滤液混合减压浓缩得浸膏、干燥即得治疗稳定性心绞痛的中药组合物。
在本发明中,步骤(1)所述物料1与水的质量比为1:3~5;优选为1:4。
在本发明中,步骤(1)所述浸提的时间为1.5~2.5h;优选为2h。
在本发明中,步骤(1)所述浸提的温度为55~65℃;优选为57~63℃;进一步优选为59~61℃;更优选为60℃。
在本发明中,步骤(2)所述滤渣1与水的质量比为1:2~4;优选为1:3。
在本发明中,步骤(2)所述煎煮的时间为2.5~3.5h;优选为3h。
在本发明中,步骤(3)减压浓缩至55℃时相对密度为1.10~1.20的浸膏;优选为1.15。
在本发明中,步骤(3)所述干燥的温度为50~60℃;优选为52~58℃;进一步优选为54~56℃;更优选为55℃。
在本发明中,步骤(3)所述干燥的时间为3.5~4.5h;优选为4h。
下面结合实施例对本发明提供的技术方案进行详细的说明,但是不能把它们理解为对本发明保护范围的限定。
实施例1
一种治疗稳定性心绞痛的中药组合物的制备方法,步骤如下:
(1)将黄芪25份、丹参25份、瓜蒌10份、黄连10份、三七2份、玄参10份、浙贝母25份、虎杖25份、桃仁10份、牡蛎25份、茯苓8份、白前5份和桑叶7份混合,得物料1,将物料1与水按质量比为1:3混合,55℃浸提1.5h,过滤得浸提液和滤渣1;
(2)将滤渣1与水按质量比为1:2混合煎煮2.5h,过滤得滤液;
(3)将所述浸提液与滤液混合减压浓缩至55℃时相对密度为1.10的浸膏,50℃干燥3.5h即得治疗稳定性心绞痛的中药组合物。
实施例2
一种治疗稳定性心绞痛的中药组合物的制备方法,步骤如下:
(1)将黄芪35份、丹参35份、瓜蒌20份、黄连20份、三七4份、玄参20份、浙贝母35份、虎杖35份、桃仁14份、牡蛎35份、茯苓12份、白前15份和桑叶11份混合,得物料1,将物料1与水按质量比为1:5混合,65℃浸提2.5h,过滤得浸提液和滤渣1;
(2)将滤渣1与水按质量比为1:4混合煎煮3.5h,过滤得滤液;
(3)将所述浸提液与滤液混合减压浓缩至55℃时相对密度为1.20的浸膏,60℃干燥4.5h即得治疗稳定性心绞痛的中药组合物。
实施例3
一种治疗稳定性心绞痛的中药组合物的制备方法,步骤如下:
(1)将黄芪30份、丹参30份、瓜蒌15份、黄连15份、三七3份、玄参15份、浙贝母30份、虎杖30份、桃仁12份、牡蛎30份、茯苓10份、白前10份和桑叶9份混合,得物料1,将物料1与水按质量比为1:4混合,60℃浸提2h,过滤得浸提液和滤渣1;
(2)将滤渣1与水按质量比为1:3混合煎煮3h,过滤得滤液;
(3)将所述浸提液与滤液混合减压浓缩至55℃时相对密度为1.15的浸膏,55℃干燥4h即得治疗稳定性心绞痛的中药组合物。
实验例1
对60例平均年龄在52.4岁的稳定性心绞痛患者进行治疗,其中病情诊断采信正规医院出具的医生诊断。随机平均分为实验组3和现有技术组3(男女各半)。
实验组3给予实施例3得到的产品:服用方法为:8g/次,温水冲服,每天3次;
现有技术组3:服用氯吡格雷,75mg1日1次口服给药。
诊断标准为:稳定性心绞痛主要症状有胸部刺痛,固定不移,入夜更甚,有时心悸不宁。胸闷如窒而痛,或者痛引肩背,胸闷气短,肢体感到沉重,形体肥胖。胸痛彻背,感寒痛甚,并伴有心悸,重则喘息,偶尔会有濒死的恐惧感觉,严重者大汗淋漓并伴有压榨性疼痛。
实验组3及现有技术组3对患者进行3个月的治疗,以上所有症状消失即为治愈;有1~2个症状减轻,以上症状消失或所有症状均有明显的改善为有效;所有症状不消失或无明显改善为无效。
实验完成后,调查各实验组的治疗效果,结果如表5所示。
表1稳定性心绞痛治疗效果调查表
由表1记载的内容不难看出,本发明所提供的组合物对于稳定性心绞痛具有优异的治疗效果,其与现有技术药物氯吡格雷的总有效率及治愈率基本相同。
以上所述仅是本发明的优选实施方式,应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。
Claims (9)
1.一种治疗稳定性心绞痛的中药组合物,其特征在于,由如下质量份数的组分制备而成:黄芪25~35份、丹参25~35份、瓜蒌10~20份、黄连10~20份、三七2~4份、玄参10~20份、浙贝母25~35份、虎杖25~35份、桃仁10~14份、牡蛎25~35份、茯苓8~12份、白前5~15份和桑叶7~11份。
2.权利要求1所述的一种治疗稳定性心绞痛的中药组合物的制备方法,其特征在于,包括如下步骤:
(1)将黄芪、丹参、瓜蒌、黄连、三七、玄参、浙贝母、虎杖、桃仁、牡蛎、茯苓、白前和桑叶混合,得物料1,将物料1与水混合浸提,过滤得浸提液和滤渣1;
(2)将滤渣1与水混合煎煮,过滤得滤液;
(3)将所述浸提液与滤液混合减压浓缩得浸膏、干燥即得治疗稳定性心绞痛的中药组合物。
3.根据权利要求2所述的制备方法,其特征在于,步骤(1)所述物料1与水的质量比为1:3~5。
4.根据权利要求3所述的制备方法,其特征在于,步骤(1)所述浸提的时间为1.5~2.5h;所述浸提的温度为55~65℃。
5.根据权利要求2所述的制备方法,其特征在于,步骤(2)所述滤渣1与水的质量比为1:2~4。
6.根据权利要求5所述的制备方法,其特征在于,步骤(2)所述煎煮的时间为2.5~3.5h。
7.根据权利要求2所述的制备方法,其特征在于,步骤(3)减压浓缩至55℃时相对密度为1.10~1.20的浸膏。
8.根据权利要求2所述的制备方法,其特征在于,步骤(3)所述干燥的温度为50~60℃。
9.根据权利要求2或8所述的制备方法,其特征在于,步骤(3)所述干燥的时间为3.5~4.5h。
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