CN116547270A - 4-(2-氟-4-甲氧基-5-3-(((1-甲基环丁基)甲基)氨基甲酰基)双环[2.2.1]庚-2-基)氨基甲酰基)苯氧基)-1-甲基环己烷-1-甲酸衍生物以及类似化合物作为rxfp1调节剂用于治疗心力衰竭 - Google Patents

4-(2-氟-4-甲氧基-5-3-(((1-甲基环丁基)甲基)氨基甲酰基)双环[2.2.1]庚-2-基)氨基甲酰基)苯氧基)-1-甲基环己烷-1-甲酸衍生物以及类似化合物作为rxfp1调节剂用于治疗心力衰竭 Download PDF

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Publication number
CN116547270A
CN116547270A CN202180075461.3A CN202180075461A CN116547270A CN 116547270 A CN116547270 A CN 116547270A CN 202180075461 A CN202180075461 A CN 202180075461A CN 116547270 A CN116547270 A CN 116547270A
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China
Prior art keywords
carbamoyl
bicyclo
fluoro
carboxylic acid
hept
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Pending
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CN202180075461.3A
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English (en)
Chinese (zh)
Inventor
K·L·格兰伯格
G·贝尔贡齐尼
H·F·博格斯特罗姆
S·J·博斯特罗姆
H·格拉登
L·J·A·乌兰德
坂槙茂辉
渊上龙一
丹羽靖哉
藤尾雅和
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Tanabe Pharma Corp
AstraZeneca AB
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Mitsubishi Tanabe Pharma Corp
AstraZeneca AB
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Publication of CN116547270A publication Critical patent/CN116547270A/zh
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    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • A61K31/275—Nitriles; Isonitriles
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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CN202180075461.3A 2020-12-08 2021-12-07 4-(2-氟-4-甲氧基-5-3-(((1-甲基环丁基)甲基)氨基甲酰基)双环[2.2.1]庚-2-基)氨基甲酰基)苯氧基)-1-甲基环己烷-1-甲酸衍生物以及类似化合物作为rxfp1调节剂用于治疗心力衰竭 Pending CN116547270A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063122690P 2020-12-08 2020-12-08
US63/122690 2020-12-08
PCT/EP2021/084673 WO2022122773A1 (en) 2020-12-08 2021-12-07 4-(2-fluoro-4-methoxy-5-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid derivatives and similar compounds as rxfp1 modulators for the treatment of heart failure

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CN116547270A true CN116547270A (zh) 2023-08-04

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JP2024540163A (ja) * 2021-10-29 2024-10-31 ブリストル－マイヤーズ スクイブ カンパニー Ｒｘｆｐ１アゴニスト
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IL326543A (en) 2023-08-15 2026-04-01 Astrazeneca Ab Compound azd5462 for use in the treatment of heart failure
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KR20260116187A (ko) 2023-11-17 2026-07-28 일라이 릴리 앤드 캄파니 Rxfp1 수용체 효능제

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