CN116528897A - 靶向SARS-CoV-2的抗原结合分子 - Google Patents

靶向SARS-CoV-2的抗原结合分子 Download PDF

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Publication number
CN116528897A
CN116528897A CN202180052278.1A CN202180052278A CN116528897A CN 116528897 A CN116528897 A CN 116528897A CN 202180052278 A CN202180052278 A CN 202180052278A CN 116528897 A CN116528897 A CN 116528897A
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China
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polypeptide
seq
ser
cov
amino acid
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Pending
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CN202180052278.1A
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English (en)
Chinese (zh)
Inventor
G·格里戈里安
J·英格拉汉姆
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Flagship Development And Innovation Vi Co
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Flagship Development And Innovation Vi Co
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Publication of CN116528897A publication Critical patent/CN116528897A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C07K16/104—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202180052278.1A 2020-08-26 2021-08-26 靶向SARS-CoV-2的抗原结合分子 Pending CN116528897A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063070707P 2020-08-26 2020-08-26
US63/070,707 2020-08-26
PCT/US2021/047757 WO2022047033A1 (en) 2020-08-26 2021-08-26 Antigen binding molecules targeting sars-cov-2

Publications (1)

Publication Number Publication Date
CN116528897A true CN116528897A (zh) 2023-08-01

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ID=77897739

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180052278.1A Pending CN116528897A (zh) 2020-08-26 2021-08-26 靶向SARS-CoV-2的抗原结合分子

Country Status (9)

Country Link
US (1) US11987616B2 (https=)
EP (1) EP4204446A1 (https=)
JP (1) JP2023540037A (https=)
KR (1) KR20230058434A (https=)
CN (1) CN116528897A (https=)
AU (1) AU2021332340A1 (https=)
CA (1) CA3188716A1 (https=)
IL (1) IL300720A (https=)
WO (1) WO2022047033A1 (https=)

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AU2023265164A1 (en) 2022-05-06 2024-11-21 Generate Biomedicines, Inc. Antigen binding molecules targeting sars-cov-2
JP2025537301A (ja) 2022-11-13 2025-11-14 ジェネレイト バイオメディシンズ， インコーポレイテッド Ｓａｒｓ－ｃｏｖ－２を標的とする抗原結合分子
CN117442594A (zh) * 2023-04-20 2024-01-26 厦门大学 化合物在诊断与治疗新型冠状病毒感染中的应用

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Publication number Publication date
EP4204446A1 (en) 2023-07-05
US11987616B2 (en) 2024-05-21
JP2023540037A (ja) 2023-09-21
AU2021332340A9 (en) 2024-05-09
CA3188716A1 (en) 2022-03-03
AU2021332340A1 (en) 2023-10-05
US20230287089A1 (en) 2023-09-14
KR20230058434A (ko) 2023-05-03
WO2022047033A1 (en) 2022-03-03
IL300720A (en) 2023-04-01

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