CN116492431A - Medicine for treating flat wart and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating flat wart, which is prepared from aconite, cassia twig, scouring rush, fructus liquidambaris, peach kernel, safflower, red paeony root, angelica, szechuan lovage rhizome, white paeony root, honeysuckle, weeping forsythiae capsule, common selfheal fruit-spike, chinese thorowax root, coix seed, indian buead, membranous milkvetch root, tangerine peel, cape jasmine, platycodon root and almond. Based on the traditional Chinese medicine theory basis of yang-qi transformation and yin formation, the traditional Chinese medicine composition has the effects of warming yang, dredging collaterals, promoting qi circulation, activating blood, resolving phlegm, resolving masses, detoxifying and eliminating rash, and is suitable for people suffering from flat warts.

Description

Medicine for treating flat wart and preparation method thereof

The invention field:

the invention relates to a medicine for treating verruca plana and a preparation method thereof, belonging to the technical field of medicines.

Background

Flat warts are viral infectious diseases caused by Human Papilloma Virus (HPV) infection, which are well developed in adolescents, and can be transmitted by direct contact with the affected area or contact with the products contaminated by the patient, etc. Clinically, it is manifested as a flat pimple with a skin color or pink color, mostly seen on the face and back of the hand, without obvious subjective symptoms, and chronic disease course. Infection may be by direct or indirect contact.

The course of the disease is chronic, and can last for many years, and external medicines and physical treatments are generally adopted, wherein the external medicines can be treament such as tretinoin ointment, imiquimod ointment and the like, and the physical treatments comprise freezing and laser treatment. The external medicine and the physical therapy effect are not ideal when being singly used, and the combination therapy is carried out by combining the traditional Chinese medicine with the physical therapy, so that the treatment effect of the flat wart can be greatly improved.

The invention relates to a yang warming wart removing prescription, which combines syndrome differentiation, disease differentiation and syndrome differentiation, and is a special prescription for treating flat wart due to the principle of differentiation and treatment of people, time and place.

Disclosure of Invention

The invention aims to provide a medicine for treating verruca plana and a preparation method thereof. Based on the traditional Chinese medicine theory basis of yang-qi transformation and yin formation, the traditional Chinese medicine composition has the effects of warming yang, dredging collaterals, promoting qi circulation, activating blood, resolving phlegm, resolving masses, detoxifying and eliminating rash, and is suitable for people suffering from flat warts.

In order to solve the technical problems, the invention is realized by adopting the following technical scheme:

the medicine for treating flat wart comprises the following medicinal active ingredients in parts by weight: is prepared from radix aconiti carmichaeli 50-150 parts, cassia twig 100-200 parts, scouring rush 100-200 parts, fructus liquidambaris, peach kernel 50-150 parts, safflower 50-150 parts, red peony root 50-150 parts, chinese angelica 100-200 parts, ligusticum wallichii 40-130 parts, white peony root 150-250 parts, honeysuckle 100-200 parts, capsule of weeping forsythiae 180-320 parts, selfheal 100-200 parts, bupleurum 100-200 parts, coix seed 200-400 parts, poria cocos 70-170 parts, astragalus root 150-250 parts, dried orange peel 100-200 parts, cape jasmine 50-150 parts, balloonflower 50-150 parts and almond 40-130 parts.

The medicine for treating flat wart comprises the following medicinal active ingredients in parts by weight: is prepared from 80-120 parts of aconite, 120-180 parts of cassia twig, 120-180 parts of scouring rush, 120-180 parts of fructus liquidambaris, 80-120 parts of peach kernel, 80-120 parts of safflower, 80-120 parts of red paeony root, 120-180 parts of angelica, 70-110 parts of szechuan lovage rhizome, 170-230 parts of white paeony root, 120-180 parts of honeysuckle, 200-300 parts of weeping forsythiae capsule, 120-180 parts of common selfheal fruit-spike, 120-180 parts of Chinese thorowax root, 250-350 parts of coix seed, 100-140 parts of Indian buead, 170-230 parts of membranous milkvetch root, 120-180 parts of tangerine peel, 80-120 parts of cape jasmine, 80-120 parts of platycodon root and 70-110 parts of almond.

Specifically, the medicine for treating flat wart comprises the following medicinal active ingredients in parts by weight: is prepared from 100 parts of aconite, 150 parts of cassia twig, 150 parts of scouring rush, 150 parts of fructus liquidambaris, 100 parts of peach kernel, 100 parts of safflower, 100 parts of red paeony root, 150 parts of angelica, 90 parts of szechuan lovage rhizome, 200 parts of white paeony root, 150 parts of honeysuckle flower, 250 parts of weeping forsythiae capsule, 150 parts of common selfheal fruit-spike, 150 parts of Chinese thorowax root, 300 parts of coix seed, 120 parts of Indian buead, 200 parts of membranous milkvetch root, 150 parts of tangerine peel, 100 parts of cape jasmine, 100 parts of platycodon root and 90 parts of almond.

The preparation method of the medicine for treating flat wart comprises the steps of weighing all the medicinal materials according to a proportion, and processing according to a conventional preparation method to prepare corresponding medicinal preparations.

Specifically, the preparation method of the medicine for treating verruca plana comprises the steps of weighing all the medicinal materials according to a proportion, crushing the medicinal materials, uniformly mixing the medicinal materials, adding water, decocting the medicinal materials to obtain decoction, and processing the decoction according to a conventional preparation method to prepare corresponding medicinal preparations.

The medicinal preparation comprises a soft extract, a capsule, a tablet and a granule.

The decoction is prepared by the following steps: weighing the medicinal materials according to the prescription proportion, adding 10 times of water, boiling, refluxing and extracting for 3 times, 1 hour each time, combining three times of extracting solutions, uniformly mixing, concentrating into 70% of the original medicinal liquid, filtering while the hot, concentrating the filtrate into extract with relative density of 1.20-1.25 at 80 ℃, continuously heating with slow fire to obtain the extract, and filling into a sterile bottle when a small amount of extract can be flatly pulled into filaments or dripped on paper without water marks.

The capsules were prepared as follows: weighing the medicinal materials according to the prescription proportion, adding 8 times of water, boiling, refluxing and extracting for 2 times, each time for 2 hours, mixing the two extracting solutions, uniformly mixing, concentrating into 70% of the original medicinal liquid, filtering while the medicinal liquid is hot, concentrating the filtrate into extract with relative density of 1.20-1.25 at 80 ℃, drying the extract into dry extract at 80 ℃, pulverizing into fine powder, adding starch with the preparation amount of 5%, uniformly mixing, granulating with 80% of ethanol, drying, granulating, and filling into capsules to obtain the traditional Chinese medicine.

The tablets were prepared as follows: weighing the medicinal materials according to the prescription proportion, adding 12 times of water, boiling, refluxing and extracting for 2 times, 1.5 hours each time, combining the two extracting solutions, uniformly mixing, concentrating into 70% of the original medicinal liquid, filtering while the hot, concentrating the filtrate into extract with relative density of 1.15-1.20 at 80 ℃, drying the extract into dry extract at 80 ℃, crushing the dry extract into fine powder to obtain dry extract, taking the dry extract, adding 10% of pregelatinized starch, uniformly mixing, granulating with 75% of ethanol as a wetting agent, drying, tabletting and film coating to obtain the traditional Chinese medicine.

The granule is prepared by the following steps: weighing the medicinal materials according to the prescription proportion, adding 6 times of water, boiling, refluxing and extracting for 3 times, 1.5 hours each time, merging the three extracting solutions, uniformly mixing, concentrating into 80% of the original medicinal liquid, filtering while the hot, concentrating the filtrate into extract with relative density of 1.15-1.20 at 80 ℃, drying the extract at 80 ℃, crushing the extract into fine powder to obtain dry extract, taking 1 part of dry extract, 1 part of sucrose, preparing particles by a wet method, drying at 80 ℃, sieving for 1 time by a 16-mesh sieve, and sieving the fine powder by a 60-mesh sieve to obtain the finished product.

Compared with the prior art, the invention has the following beneficial effects:

the medicine for treating flat wart is prepared from aconite, cassia twig, scouring rush, fructus liquidambaris, peach kernel, safflower, red paeony root, angelica, szechuan lovage rhizome, white paeony root, honeysuckle, weeping forsythiae capsule, selfheal, radix bupleuri, coix seed, indian buead, astragalus root, tangerine peel, gardenia, platycodon root and almond. The properties and efficacy of each component are as follows: radix Aconiti lateralis is a processed product of the root of Aconitum carmichaeli Aconitum carmichaelii Debx belonging to Ranunculaceae; pungent and sweet in flavor, and strong in heat; return to heart, kidney and spleen meridians; has effects of restoring yang, rescuing collapse, nourishing fire, supporting yang, dispelling cold, and relieving pain; can be used for treating yang depletion, cold limbs, heart yang deficiency, chest pain, vomiting and diarrhea due to cold, cold pain in the stomach and abdomen, kidney yang deficiency, sexual impotence, cold womb, edema due to cold yin, yang deficiency exogenous pathogenic factor, and cold dampness arthralgia. Ramulus Cinnamomi is dried twig of Cinnamomum cassia Cinnamomum cassia Presl belonging to Lauraceae; harvesting in spring and summer, removing leaves, sun drying, or slicing and sun drying; pungent and sweet in taste and warm in nature; return to heart, lung and bladder meridians; has effects of inducing sweat, relieving muscle, warming and activating meridian, supporting yang, activating qi-flowing, and calming the pulse to descend; can be used for treating common cold due to wind-cold, abdominal pain, amenorrhea due to blood cold, arthralgia, phlegm retention, edema, palpitation, and dolphin. Scouring rush is whole herb of scouring rush (academic name: equisetum hyemale L.) belonging to the family scouring rush, and is sweet, bitter and neutral in taste; has effects of dispelling pathogenic wind and heat, improving eyesight, removing nebula, and stopping bleeding; can be used for treating conjunctival congestion, swelling and pain, corneal nebula, enteritis, diarrhea, jaundice, and urinary calculus caused by wind heat. Fructus Lipuidambaris is dried mature fruit sequence of Liquidambar Liquidambar formosana Hance of Hamamelidaceae; bitter taste and neutral nature; enter liver and kidney meridians; has effects of dispelling pathogenic wind, activating collaterals, promoting diuresis and dredging channels; can be used for treating arthralgia, numbness, contracture, edema, fullness, hypogalactia, and amenorrhea. Semen Persicae is dried mature seed of Prunus persica (L.) Batsch or Prunus davidiana (Carr.) Franch of Rosaceae; harvesting after the fruits are ripe, removing pulp and nucleocapsids, taking out seeds, and sun-drying; bitter and sweet in taste and neutral in nature; return to heart, liver and large intestine; has effects of promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, relieving cough and asthma; can be used for treating amenorrhea dysmenorrhea, abdominal mass, pulmonary abscess, intestinal abscess, traumatic injury, constipation due to intestinal dryness, cough and asthma. Safflower is a dried flower of Compositae plant safflower Carthamus tinctorius L. Picking the flowers in summer when the flowers turn from yellow to red, and drying in the shade or sun-drying; pungent taste and warm nature; return to heart and liver meridian; has effects of promoting blood circulation, dredging channels, removing blood stasis, and relieving pain; can be used for treating amenorrhea, dysmenorrhea, lochia, mass, chest pain, abdominal pain, stabbing pain in chest and hypochondrium, traumatic injury, and swelling and pain of sores. Radix Paeoniae Rubra is dried root of Pall of Paullinia herbaceous peony Paeonia lactiflora or Paeonia veitchii Lynch of radix Paeoniae Rubra; bitter taste and slightly cold nature; enter liver meridian; has effects of clearing heat, cooling blood, removing blood stasis and relieving pain; can be used for treating heat entering nutrient blood, toxic heat, speckle, hematemesis, epistaxis, conjunctival congestion, swelling and pain, liver Yu Xie pain, amenorrhea, dysmenorrhea, abdominal mass, abdominal pain, traumatic injury, carbuncle, swelling and sore. Angelica sinensis is the dry root of Angelica sinensis Angelica sinensis (Oliv.) Diels of Umbelliferae; digging in the late autumn, removing fibrous roots and silt, bundling into small bundles after water is slightly evaporated, and slowly smoking with smoke; sweet and pungent taste and warm nature; enter liver, heart and spleen meridians; has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel, and relieving constipation; can be used for treating sallow complexion due to blood deficiency, dizziness, palpitation, menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency-cold, rheumatalgia, traumatic injury, carbuncle, skin ulcer, and constipation due to intestinal dryness; the wine angelica has the effects of promoting blood circulation and dredging channels; can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, traumatic injury. Rhizoma Ligustici Chuanxiong is dried rhizome of Ligusticum chuanxiong Hort Ligusticum chuanxiong Hort of Umbelliferae; digging in summer when the node discs on the stems are obviously protruded and are slightly purple, removing sediment, drying after sun drying, and removing fibrous roots; pungent taste and warm nature; meridian tropism between liver, gallbladder and pericardium; has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, and relieving pain; can be used for treating chest pain, hypochondrium pain, traumatic injury, menoxenia, amenorrhea, dysmenorrhea, abdominal pain, headache, and rheumatalgia. Radix Paeoniae alba is dry root of Pall Paeonia lactiflora of Pall of Ranunculaceae; bitter and sour in taste and slightly cold in nature; enter liver and spleen meridians; has effects of nourishing blood, regulating menstruation, astringing yin, suppressing sweating, softening liver, relieving pain, and suppressing liver yang; can be used for treating sallow complexion due to blood deficiency, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb contracture pain, headache and dizziness. The flos Lonicerae is dried flower bud or flower with initial bloom of Lonicera japonica of Caprifoliaceae Lonicera japonica thunder; harvesting and drying the flowers before opening the summer flowers; sweet in taste and cold in nature; enter lung, heart and stomach meridians; has effects of clearing heat and detoxicating, dispelling pathogenic wind and heat; can be used for treating carbuncle, furuncle, pharyngitis, erysipelas, dysentery with blood, wind-heat type common cold, and epidemic febrile disease. Fructus forsythiae is a dried fruit of Forsythia suspensa Forsythia suspensa (thunder.) Vahl belonging to Oleaceae; bitter taste and slightly cold nature; enter the lung, heart and small intestine meridians; has effects of clearing heat and detoxicating, detumescence and resolving hard mass, dispelling wind and heat; can be used for treating carbuncle, scrofula, acute mastitis, erysipelas, wind-heat type common cold, epidemic febrile disease, excessive heat, polydipsia, coma, speckle, and stranguria due to heat. Prunella vulgaris is dry ear of Prunella vulgaris Prunella vulgaris L; pungent and bitter in flavor and cold in nature; enter liver and gallbladder meridians; has effects of clearing liver-fire, improving eyesight, resolving hard mass and detumescence; can be used for treating conjunctival congestion, headache, dizziness, scrofula, goiter, acute mastitis, hyperplasia of mammary glands, and breast pain. Radix bupleuri is dry root of Bupleurum scorzonerifolium Bupleurum chinense DC or Bupleurum scorzonerifolium Bupleurum scorzonerifolium Willd; according to different characters, it is known as "North Bupleurum" and "south Bupleurum"; digging in spring and autumn, removing stems and leaves and silt, and drying; pungent and bitter in flavor and slightly cold in nature; enter liver, gall bladder and lung meridian; has effects of dispelling heat, dispersing stagnated liver qi, relieving qi stagnation, and lifting yang qi; can be used for treating common cold, fever, distending pain in chest and hypochondrium, menoxenia, uterine prolapse, and rectocele. Coix lacryma-jobi L.var.ma-yuen (Roman.) dry mature seed of Coix lacryma-jobi of Gramineae; harvesting plants when the autumn fruits are ripe, sun-drying, peeling the fruits, sun-drying, removing the shells, the yellow brown seed coats and impurities, and collecting kernels; sweet and light in taste and cool in nature; spleen, stomach and lung meridian; has effects in promoting diuresis, removing dampness, invigorating spleen, relieving diarrhea, relieving arthralgia, expelling pus, removing toxic materials, and resolving hard mass; can be used for treating edema, tinea pedis, dysuria, spleen deficiency, diarrhea, spasm of damp arthralgia, pulmonary abscess, appendicitis, and cancer. Poria is dry sclerotium of Polyporaceae fungus Poria cocos (Schw.) Wolf; sweet and light in taste and neutral in nature; return to heart, lung, spleen and kidney meridians; has effects in promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; can be used for treating edema, oliguria, phlegm retention, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia. The radix astragali product is dried root of Mongolian radix astragali Astragalus membranaceus (Fisch.) bge. Var. Mongholicus (bge.) Hsiao or Astragalus membranaceus Astragalus membranaceus (Fisch.) bge. Of Leguminosae; digging in spring and autumn, removing soil, fibrous roots and root heads, sun drying to six seven times, straightening, bundling and sun drying; sweet taste and slightly warm nature; enter lung and spleen meridians; the main functions are as follows: tonifying qi and yang, strengthening exterior and arresting sweating, inducing diuresis and relieving edema, promoting fluid production and nourishing blood, promoting stagnancy and relieving arthralgia, expelling toxin and pus, healing sore and promoting granulation; can be used for treating qi deficiency, debilitation, loose stool, depression of middle-jiao, chronic diarrhea, rectocele, hematochezia, metrorrhagia, spontaneous perspiration, qi deficiency, edema, internal heat, diabetes, blood deficiency, sallow complexion, hemiplegia, arthralgia, numbness, carbuncle, ulcer, and chronic ulcer. Pericarpium Citri Tangerinae is dried mature pericarp of Citrus reticulata Blanco Citrus reticulata Blanco and its cultivar; bitter and pungent taste and warm nature; enter lung and spleen meridians; has effects of regulating qi-flowing, invigorating spleen, eliminating dampness and resolving phlegm; can be used for treating abdominal distention, anorexia, vomiting and diarrhea, cough with excessive phlegm. Fructus Gardeniae is dried mature fruit of fructus Gardeniae Gardenia jasminoides Ellis of Rubiaceae plant; harvesting when the fruits are ripe and red-yellow for 9-11 months, removing the fruit stalks and impurities, steaming to the upper air or putting the fruits into boiling water for scalding slightly, taking out and drying; bitter in flavor and cold in nature. Return to heart, lung and triple energizer meridians; has effects in purging pathogenic fire, relieving restlessness, clearing away heat and dampness, cooling blood, and removing toxic substances; the external use has the effects of detumescence and pain relief; can be used for treating febrile vexation, jaundice due to damp-heat, stranguria, hematemesis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to pathogenic fire; it is indicated for sprain, contusion and pain. Radix Platycodi is dry root of radix Platycodi Platycodon grandiflorum (Jacq.) A.DC; bitter and pungent taste and neutral nature; enter lung meridian; has effects in dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus; can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, pulmonary abscess, and pus discharge. The almond is a dried mature seed of mountain apricot Prunus armeniaca l.var. Ansu maxim, siberia apricot Prunus sibirica l, northeast apricot Prunus mandshurica (maxim.) Koehne or apricot Prunus armeniaca l; harvesting ripe fruits in summer, removing pulp and core shells, taking out seeds, and sun-drying; bitter taste and slightly warm nature; the Chinese medicinal composition has small toxicity; lung and large intestine channels; has effects of lowering qi, relieving cough and asthma, loosening bowel to relieve constipation; can be used for treating cough, asthma, chest fullness, excessive phlegm, constipation due to intestinal dryness.

Square solution

Monarch drug: radix aconiti carmichaeli, cassia twig, scouring rush herb and fructus liquidambaris

Fuzi is pungent, sweet and hot, and can restore heart, spleen and kidney meridians, has the effects of restoring yang, rescuing collapse, tonifying fire, tonifying yang, dispelling cold and relieving pain, can strengthen heart yang, warm spleen yang, and tonify kidney yang, and is prepared from Ben Cao in Xin (new): for acne, sore and grey white, all kinds of cold due to sinking cold. Ramulus Cinnamomi is pungent and sweet in taste and warm in nature, and can induce sweat to relieve exterior syndrome, dispel cold to alleviate pain, and activate yang to transform qi. The cassia twig has the effects of activating yang, promoting qi circulation and removing dampness, the aconite root has the effects of warming kidney, strengthening yang and tonifying fire, the aconite root has the advantages of tonifying more than powder, tonifying, recovering more than powder, tonifying more than powder, and promoting the circulation of qi, and the two herbs have the functions of tonifying yin and removing yang, regulating yin and yang, eliminating pathogenic cold-congealing phlegm and fluid retention, and dredging meridians. Scouring rush herb, which enters lung and liver channels, has the effects of dispelling wind-heat, improving eyesight, removing nebula and stopping bleeding, and is a medicine in the chapter of "Yuhua Yao Jie": "Flat sores and ulcers are hard, and spit wind, mania and phlegm. For carbuncle, cellulitis, scrofula, furuncle, sweat stain, powder and dreg, metrorrhagia, reddish and white. Fructus Lipuidambaris, bitter in taste, mild in nature, has the effects of dispelling pathogenic wind, activating collaterals, promoting diuresis and dredging channels, and can be used for treating arthralgia, numbness, spasm, edema and distention, etc. The four drugs are combined as monarch drugs, and have the effects of clearing heat, warming yang and dredging collaterals, or warming yang, dispelling cold, promoting diuresis and dredging collaterals.

Ministerial drug one: peach kernel, safflower and red peony root

Tao ren is bitter and flat, moist in nature, bitter in nature to relieve stagnant blood and body moist in nature to moisten intestine and dryness, has the actions of activating blood and resolving stasis and relaxing bowel, and is indicated for all syndromes of stagnant blood, especially for localized and tangible stagnant blood. Safflower, flos Carthami, with pungent and warm nature, is indicated for various blood stasis blocking syndromes, because it is a common herb in various formulas of activating blood for internal and external injury, because it can activate blood and promote menstruation, dispel stasis and alleviate pain. Radix Paeoniae Rubra, bitter in flavor, slightly cold in nature, has the effects of clearing heat and cooling blood, and removing blood stasis and relieving pain. The three herbs are combined, and the three herbs are ascending and descending orderly, so that the actions of dispersing and collecting are good, the actions of activating blood and removing stasis are multiplied, and the aconite root is introduced into the blood system to warm and transport the qi and the aconite root is warm and general, so that the actions of activating blood and dredging meridians of the three herbs can be promoted.

Ministerial drug II: chinese angelica, szechuan lovage rhizome and white paeony root

Dang Gui is pungent and sweet in flavor and warm in nature, enters liver, heart and spleen meridians, nourishes and warms and unblocks blood, and has the actions of regulating qi and activating blood, which is known as a holy medicine in blood. White peony root, radix Paeoniae alba, bitter in flavor, slightly cold in nature, enters liver and spleen meridians, and has the effects of nourishing blood, astringing yin, regulating nutrient and softening liver. It is combined with Dang Gui, dang Gui and Bai XueXue are used for warming yang, their sexual movement is dominant, bai Shao and Xue are used for nourishing yin, their sexual calm is dominant, both cold and warm herbs are used together, and they are combined together for nourishing yin and tonifying blood, regulating liver and spleen, and activating blood circulation to dissipate blood stasis, and it is indicated for all diseases of deficiency of qi and blood and incoordination between liver and spleen. Chuan Xiong is pungent and warm in nature, has the effects of promoting qi circulation and resolving depression, dispelling wind and removing dampness, activating blood and relieving pain, and can give consideration to qi and blood stasis, and is an essential herb for both qi and blood. The Chinese angelica and the white peony root are used for replenishing yin by blood medicines, the szechuan lovage rhizome is used for promoting blood circulation and removing the stasis by combining the three medicines, so that the Chinese angelica and the white peony root are combined as the second group of ministerial medicines.

Ministerial drug III: flos Lonicerae, fructus forsythiae, prunellae Spica

Honeysuckle flower has sweet and cold nature, enters lung and stomach and large intestine channels, has the effects of clearing heat and removing toxicity, eliminating stagnation and relieving swelling, and is a compendium of materia medica (Ben Cao gang mu): all wind and damp, all toxic swelling, carbuncle, scabies, yang Meizhu malignant boil, heat dissipation and detoxification. Fructus forsythiae, which enters lung, heart and gallbladder meridians, is good at treating carbuncle, abscess and swelling and toxicity, and is called "sores and holy medicines". The two herbs are mutually combined to treat carbuncle, swelling and furuncle due to heat-toxin and fire-toxin, and have the actions of clearing heat and removing toxicity, resolving carbuncles and resolving masses; meanwhile, the honeysuckle flower has fragrant smell, light and clear texture, is good at clearing exterior heat, is matched with fructus forsythiae and clearing interior heat and excessive fire, and transmits heat to reach exterior, and is combined with the two essential herbs for treating sore, carbuncle and swelling toxin of all yang syndromes. The common selfheal fruit-spike enters liver and gall meridians, can clear heat and purge fire, and dissipate nodulation and reduce swelling, has the effect of clearing fire and resolving nodulation, can restrict excessive nature of principal drugs caused by warm dryness, is commonly used for treating diseases caused by phlegm-fire accumulation, and is a third group of ministerial drugs.

Adjuvant drug: radix bupleuri, pericarpium Citri Reticulatae, radix astragali, poria, semen Coicis, and fructus Gardeniae

Yang moving but dispersing so as to transform qi and yin static but congealing, so it is shaped. Excessive yin coagulation, failing to transport and transform yang qi, and accumulation of damp, phlegm and blood stasis, which accumulate on the skin and muscle surface to cause warts. Bupleuri radix, having the effects of regulating exterior and interior, soothing liver and elevating yang, enters liver and gallbladder meridians. Dried orange peel, pericarpium Citri Reticulatae, bitter and pungent in flavor, warm in nature, has the effects of regulating qi-flowing, strengthening spleen, eliminating dampness and resolving phlegm. Bupleurum root can achieve the effect of activating qi and drying dampness, while dried orange peel is spicy and fragrant, and is warm and boring. Zhang Yuansu cloud "Huangqi Gan Wenchun yang, five in nature, is used to supplement deficiency; primordial qi is also benefited; strengthening spleen and stomach, thirdly; removing muscle heat, four; pus discharge and pain relief, blood circulation activating and blood generation, internal support yin-activating gangrene, sores, holy medicine, five kinds of drugs. "Huang Qi is a holy medicine for treating sores and abscess" carried in Ben Cao Bei Yao (herbal preparation of the medicine) ". It is combined with ministerial drugs (blood-nourishing and blood-activating drugs, detoxifying and resolving hard mass drugs) to benefit the defensive qi and eliminate pathogenic factors, promote blood circulation and dredge vessels, and has the effects of tonifying qi and producing blood, and strengthening body resistance and expelling toxin. Poria can tonify qi, dispel pathogenic factors, strengthen body resistance, nourish heart and spleen, promote diuresis, tonify but not drastic, benefit but not violent, and calm heart and tranquilize mind. Astragalus root, radix astragali is used for warming and transporting yang qi, so as to promote qi circulation and moisten the body, clear and ascending and turbid descending, poria is used for promoting diuresis, and the two drugs are matched with each other so as to strengthen the effects of invigorating spleen and replenishing qi, inducing diuresis and relieving swelling. Yi ren enters spleen, stomach and lung meridians. "Desmodii toxic swelling" in decoction of Coicis semen "in the theory of medicine. Not only can strengthen the body resistance, invigorate the spleen, eliminate dampness, but also eliminate pathogenic factors, detoxify and eliminate tumor. Astragalus root, radix astragali has the main effects of replenishing qi to invigorate the spleen, and poria cocos and coix seed have the main effects of promoting diuresis and removing dampness; the three medicines are combined together, one is to tonify and one is to infiltrate, and water dampness has a way to exit, so that spleen can be healthy, dampness can be removed, swelling can be eliminated, fluid can be transformed, and phlegm dampness is learned. Gardenia is bitter and cold, enters heart, lung and triple energizer meridians, ben Cao Jing Shu (materia Medica of the present invention): zhi Zi is bitter in flavor, qi and cold in nature and purges all excessive fire, so it can be indicated for all kinds of symptoms. "Yi Huo Ding Jie (first decoction for purging pathogenic fire and relieving restlessness), can be used for assisting in preparing monarch drug which is warm and dry; 2. cool blood and detoxify, and the assistant and guide medicine strengthen the ability of detoxify and cool blood.

The preparation method comprises the following steps: almond and platycodon grandiflorum

Because phlegm-fluid retention is caused by spleen and stomach failing to transport and transform, it also depends on lung failing to disperse and descend, it can block striae and skin and hair, and almond taste is bitter and slightly warm, enters lung and large intestine meridians, and has the action of dispersing lung qi. Ji Geng is bitter and pungent, and pungent in flavor, dispersing lung qi, bitter in flavor, descending qi, ascending and descending, dispersing lung qi, benefiting chest and diaphragm, descending lung qi, eliminating phlegm and expelling pus, and moist in nature, can moisten intestines and relieve constipation. The two herbs are combined, one for descending and one for dispersing, and together playing the roles of dispersing lung qi, relieving sore throat and resolving phlegm, and dredging intestines and stomach, and the root of balloonflower is led to the upper Jiao Toumian part, so that all herbs go upward to reach the affected area, so the herb is the guiding herb.

Compared with the prior art, the invention has the effects of warming yang, activating collaterals, promoting qi circulation, resolving phlegm, resolving masses, detoxifying and eliminating rash based on the traditional Chinese medicine theory basis of yang, activating qi-flowing and yin shaping, and combines the advocated' differentiation of body, disease and syndrome, and the principle of differentiation and treatment of flat wart is suitable for people suffering from flat wart due to the principle of differentiation and treatment of people, time and place.

The invention carries out a great deal of experimental study, and the following results are obtained by the experimental study:

1 clinical trial

1.1 case Source

21 cases of flat wart patients were all from the dermatological clinic of the first affiliated hospital of Guizhou traditional Chinese medicine university (also known as Guizhou middle hospital) from 10 months 2021 to 11 months 2022. Of these, 9 men and 12 women; the ages are at least 19 years old, at most 55 years old, and the average (38.38 +/-12.37) years old; the disease course is the shortest 0.17 years, the longest 3.42 years, and the average (1.70+/-0.94) years;

1.2 diagnostic criteria

Reference is made to the diagnostic criteria for flat warts (flat warts) in traditional Chinese medicine surgery: (1) The skin damage is pimple with the size from needle, rice to soybean and flat bulge; (2) The skin is round or oval, smooth in surface, hard in texture, light red, brown or normal in skin color, more in number, scattered in distribution or clustered, and new damage is often formed at the positions of scratching along the epidermis; (3) It is good for face and back of hand, usually has no subjective symptoms, and has itching feeling, and can sometimes self-subside or recur.

The differentiation and typing standard of traditional Chinese medicine: the differentiation and typing standard is prepared by referring to clinical experience and combining literature progress: (1) syndrome of wind-heat accumulation: the rash is light red, the number is more, or the rash is slightly itchy, or the rash is not itchy, and the course of the disease is short; dry mouth and no desire to drink; a red tongue with thin white or thin yellow coating and a superficial and rapid or wiry pulse. (2) Syndrome of heat stasis accumulation: longer course, harder rash, different sizes, yellow brown or dark red, no itching and no pain; a red or dark red tongue with thin and white coating and a deep and wiry pulse. (3) Syndrome of yang deficiency and cold accumulation and phlegm stagnation with each other: the rash is usually seen on the face, back of hand and upper limbs, and is mostly light brown, grey-white and flat papule, the course of the disease is as long as 1-2 years or more, with aversion to cold, soreness of waist and knees, listlessness, difficult urination or excessive urination, especially at night, spermatorrhea, and frequent and thin leucorrhea. Dark tongue, swollen tongue with white coating or slippery water, deep, thready and weak pulse.

1.3 inclusion criteria

(1) Meets the diagnosis standard of verruca plana in traditional Chinese medicine science;

(2) meets the diagnosis standard of syndrome differentiation of yang deficiency and cold coagulation and phlegm stagnation;

(3) age 18-55 years old, unlimited in sex;

(4) no oral or topical medicine or physicochemical therapy treatment was used within 1 month before the group;

(5) no diseases or mental diseases such as severe barycenter, liver, kidney, brain, etc.;

(6) the clinical test is voluntarily added, the requirement of the test is complied with, and the patient can take the medicine according to the doctor's advice to finish the test.

1.4 exclusion criteria

(1) Women in pregnancy or pregnant women or women in lactation;

(2) allergic to any of the Chinese medicinal materials in the recipe;

(3) drugs for treating acne such as retinoic acid, spironolactone, tanshinone, and Chinese medicine are taken in the last month;

(4) the combination of serious diseases may have an influence on the results of the present study;

(5) other diseases affecting the observation of efficacy.

1.5 drop and reject criteria

(1) Failure to complete a course of treatment or failure to cooperate with a therapist;

(2) terminating the tester due to serious adverse drug reactions;

(3) those treated with other medications during treatment;

(4) the tester is automatically terminated for personal reasons.

1.6 methods of treatment

The medicine is administered orally to treat wart. The composition comprises the following components: 10g of aconite, 15g of cassia twig, 15g of scouring rush, 15g of fructus liquidambaris, 10g of peach kernel, 10g of safflower, 10g of red paeony root, 15g of angelica, 9g of szechuan lovage rhizome, 20g of white paeony root, 15g of honeysuckle flower, 25g of weeping forsythiae capsule, 15g of common selfheal fruit-spike, 15g of Chinese thorowax root, 30g of coix seed, 12g of Indian buead, 20g of astragalus root, 15g of tangerine peel, 10g of cape jasmine, 10g of platycodon root and 9g of almond. The traditional Chinese medicines are all from the traditional Chinese medicine pharmacy of a first affiliated hospital of Guizhou traditional Chinese medicine university. One dose is taken every day, 5 days a week, 300ml of the medicine is brewed with boiled water, 150ml of the medicine is taken every morning and evening, and the treatment lasts for 4 weeks.

1.7 Observation index and efficacy evaluation criteria

1.7.1 skin loss scoring

Currently, no accepted flat wart skin damage scoring standard is adopted, the Guan Bianping wart evaluation content is mainly referred to Zhao Bian in the main code of Chinese clinical dermatology, and 4 items of the number, the size, the color and the subjective pruritus degree of skin damage are evaluated in combination with the actual situation of the study, and each item scoring standard is shown in table 1, wherein the skin damage size and the color are scored according to the most serious single skin damage in all skin damages. And observing the change condition of each skin damage score and total integral before and after the treatment of the patient.

TABLE 1 scoring criteria for verruca plana rash

1.7.2 efficacy evaluation criteria

Clinical effects: the curative effect index is judged by total integral change of skin lesions before and after treatment, and a nimodipine method is adopted: efficacy index = [ (total integral before treatment-total integral after treatment)/(total integral before treatment ] X100%. The method comprises the following steps of specifically referring to Guan Bianping wart curative effect evaluation criteria in traditional Chinese medicine disease diagnosis curative effect criteria published by the national traditional Chinese medicine administration to be formulated:

(1) and (3) healing: the skin damage completely subsides, a small amount of pigmentation can be remained, and the curative effect index is more than or equal to 95%;

(2) the effect is shown: most of skin damage is resolved, and the curative effect index is less than or equal to 70% and less than 95%;

(3) The method is effective: the skin damage part is resolved, and the curative effect index is less than or equal to 30 percent and less than 70 percent;

(4) invalidation: the skin damage is not obviously changed, the curative effect index is less than 30 percent, or the disease is aggravated.

Total effective rate = [ (number of recovery cases + number of significant cases + number of effective cases)/(total cases) ] X100%.

1.7.3 recurrence rate

If the patient healed 2 months after the end of the treatment, the occurrence of new warts in the original site or other sites is considered as recurrence, recurrence rate=recurrence number/total cure number X100%.

1.7.4 security observations

And observing adverse reaction occurrence conditions in the treatment process of the patient, and evaluating the safety of the treatment scheme.

1.8 statistical methods

The statistical method of the study statistical method adopts SPSS 22.0 statistical software to carry out statistical analysis of data. Mean ± standard deviation for metering dataThe method is characterized in that paired sample t-test is adopted for comparison before and after treatment in the group, and two independent sample t-test is adopted for comparison between groups; the usage rate or composition ratio of the counting data is expressed, and X is adopted for comparison among groups ² And (5) checking. All of the tests were performed using a two-sided test,with P<A difference of 0.05 is statistically significant.

2 results

2.1 statistics of patient treatment effectiveness are shown in Table 2.

TABLE 2 patient treatment efficacy

Group of

n

Healing of the wound

Has obvious effect

Effective and effective

Invalidation of

Total effective rate

Test group

21 cases

2 example (9%)

0 example (0%)

17 (82%)

2 example (9%)

91％

2.2 Total integral comparison before and after treatment

The Wilcoxon sign rank sum test of the related samples is adopted for the total integral before and after the treatment of the patient, and the total integral after the treatment is reduced (P is less than 0.05) compared with the total integral before the treatment through the test, so that the total integral has statistical significance. See table 3.

TABLE 3 comparison of total integral before and after treatment

2.3 comparison of the integral of each item before and after treatment

The Wilcoxon sign rank combination test of the related samples is adopted for each skin damage integral before and after the treatment of the patient, and each integral after the treatment is reduced (P is less than 0.05) compared with the integral before the treatment, so that the difference has statistical significance. See table 4.

TABLE 4 integral comparison of skin lesions before and after treatmentDividing into two parts

2.4 safety and recurrence Rate

No adverse reaction occurred in 21 patients. After 2 months of treatment, the telephone is followed up, and 1 patient in 2 cases of patients with recovery sees a few new warts at the original position, and the recurrence rate is 50%.

Discussion 3

Flat warts are benign proliferative and destructive diseases common in dermatology, are caused by human papillomavirus infection, and are represented as pimples with rice or mung bean size flat ridges, which affect the beauty. The inventor has discovered in ten years that: the flat wart patients have the characteristics of longer disease course, repeated attack and intractable recovery, and are often accompanied with complexion The symptoms of yang deficiency failing to warm up such as white and cold hands and feet, and the like are aimed at the symptoms of yang deficiency, congealing cold, qi and blood disharmony and exogenous toxin evil; disease is caused by multiple factorsThe body's healthy qi is weak, qi and blood are not concentrated or liver qi is depressed, striae and striae are not dense, exogenous evil is felt again, skin is coagulated, repeated attacks are carried out, and the skin is lingering for a long time and is not healed, so that yang qi is consumed, qi is not beneficial, and the symptoms of transformation are pathogenic yin-cold such as dampness, phlegm and blood stasis, and the skin is coagulated to form flat wart. The inventor follows the principle of "differentiation of body, differentiation of disease and differentiation of symptoms" advocated by the teaching of the medical science Gu Min of the university, and the differentiation of treatment is suitable for people, time and place, and is used for treating the special prescription of flat wart.

In the recipe, fuzi is pungent, sweet and hot, and enters heart, spleen and kidney meridians, and has the effects of restoring yang, rescuing from collapse, tonifying fire, supporting yang, dispelling cold and relieving pain, and can be used for tonifying heart yang, warming spleen yang, and tonifying kidney yang. Gui Zhi has the actions of inducing sweat to relieve exterior syndrome, dispelling cold to alleviate pain, and activating yang to promote qi. The cassia twig has the effects of activating yang, promoting qi circulation and removing dampness, the aconite root has the effects of warming kidney, strengthening yang and tonifying fire, the aconite root has the advantages of tonifying more than powder, tonifying, recovering more than powder, and tonifying the whole body, and the two herbs have the functions of harmonizing yin and yang, dispelling cold, resolving phlegm and resolving evil, dredging channels and collaterals and relieving symptoms. Equisetum herb is good at dispelling wind-heat, and "Aronia melanocarpa solution" is said to be: "Flat sores and ulcers are hard, and spit wind, mania and phlegm. For carbuncle, cellulitis, scrofula, furuncle, sweat stain, powder and dreg, metrorrhagia, reddish and white. "Liu Tong" has the actions of dispelling wind and activating collaterals, promoting diuresis and dredging channels. The four drugs are combined as monarch drugs, and have the effects of clearing heat, warming yang and dredging collaterals, or warming yang, dispelling cold, promoting diuresis and dredging collaterals. Semen Persicae has the effects of relieving stagnation of blood, moistening body, moistening intestine, and drying, and has the effects of promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, and is especially good for local blood stasis. Safflower, flos Carthami, with the actions of clearing heat and cooling blood, dispelling stasis and alleviating pain, is indicated for various blood stasis and stagnation syndromes because it is pungent and warm in nature and can promote blood circulation and unblock menstruation. The three herbs are combined, and the three herbs are ascending and descending orderly, so that the actions of dispersing and collecting are good, the actions of activating blood and removing stasis are multiplied, and the aconite root is introduced into the blood system to warm and transport the qi and the aconite root is warm and general, so that the actions of activating blood and dredging meridians of the three herbs can be promoted. The angelica sinensis is sweet, has the effects of tonifying, warming and activating, enriching blood, regulating qi and activating blood, and the white paeony root has the effects of nourishing blood, astringing yin, regulating nutrient and softening liver, and the white paeony root enters liver and spleen channels. The two drugs are combined with one another in cold and warm nature to achieve the effects of nourishing yin and tonifying blood, regulating liver and spleen, and promoting blood circulation to remove blood stasis, and are mainly used for treating all diseases of deficiency of qi and blood and incoordination between liver and spleen. Chuan Xiong is pungent and warm in nature and can treat both qi and blood stasis. Honeysuckle flower, flos Lonicerae, with sweet and cold nature, has the effects of clearing heat and detoxicating, resolving hard mass and detumescence, fructus forsythiae is good at treating carbuncle, ulcer and swelling, and Spica Prunellae can clear heat and purge fire, resolve hard mass and detumescence, and the three are used together, so its effect of clearing fire and resolving hard mass is enhanced, and it also can restrict the warm and dry nature of monarch drugs. Radix bupleuri has the effects of relieving exterior syndrome, soothing liver, and raising yang, and pericarpium citri reticulatae has the effects of regulating qi, strengthening spleen, eliminating dampness and resolving phlegm, and the two herbs have the effects of promoting qi circulation and eliminating dampness. Zhang Yuansu cloud "Huangqi Gan Wenchun yang, five in nature, is used to supplement deficiency; primordial qi is also benefited; strengthening spleen and stomach, thirdly; removing muscle heat, four; pus discharge and pain relief, blood circulation activating and blood generation, internal support yin-activating gangrene, sores, holy medicine, five kinds of drugs. The combination of ministerial drugs (blood-nourishing and blood-activating drugs, detoxifying and resolving masses) can benefit the defensive qi, eliminate pathogenic factors, promote blood circulation and promote blood circulation. Poria has effects of invigorating spleen, promoting diuresis and detumescence, and the two herbs are combined to strengthen spleen and qi, promote diuresis and detumescence. The coix seed not only can strengthen the body resistance, invigorate the spleen and eliminate dampness, but also can eliminate pathogenic factors, detoxify and eliminate tumors. The three medicines are combined together, so that spleen can be healthy, dampness can be removed, swelling can be eliminated, fluid can be transformed, and phlegm-dampness is eliminated. Gardenia is bitter and cold, and can purge fire and relieve restlessness, and can assist in preparing monarch drugs with excessive dryness; secondly, cooling blood and detoxifying, and assisting ministerial drugs strengthen the efficacy of detoxifying and cooling blood. Because phlegm-fluid retention is caused by spleen and stomach qi failing to transform and descend, lung qi failing to disperse and descend, skin and skin striae are blocked, almond and platycodon root disperse lung qi, so that exterior excess pathogenic factors are discharged from skin and direct upward to disease location, the drugs are combined as guiding drugs. The medicines together play the roles of warming yang and dredging collaterals, promoting qi and activating blood, resolving phlegm and resolving masses, and detoxifying and eliminating rash.

Analysis of the test results: of the 21 patients enrolled in this study, 12 (57%) women and 9 (43%) men. Women are slightly more than men and may be associated with this condition being a skin disorder of impaired beauty. The disease is well developed at exposed parts of the face, and the like, affects the beauty, and has no subjective symptoms except for occasional pruritus. However, female patients tend to pay more attention to such problems, and male patients mostly do not choose to seek medical attention. Therefore, the selection of medical treatment is often a group with severe skin damage development, attractive appearance influence and personal appearance, and the medical treatment does not have crowd universality. From the result of effectiveness, the total effective rate of the formula for treating warts by taking warm yang reaches 91%, and the analysis of skin damage scores shows that the differences of the skin damage scores before and after treatment and total integral comparison have obvious statistical significance (P is less than 0.05). The prescription for warming yang and removing warts is described to treat the flat system, and has clinical treatment value in improving the effectiveness of clinical symptoms and physical signs of the flat system.

The recurrence rate was found to be 50% by 2 months follow-up after the end of the course of treatment. The method is not related to shorter follow-up period and less sample size, and can not more comprehensively reflect the recurrence condition and the long-term curative effect after taking the medicine. In addition, the patients taking the prescription have no adverse reaction and high compliance. The reason is considered to be that: (1) the symptoms and signs of the patient are improved to a certain extent after taking the medicine; (2) The treatment method has the characteristics of no wound and no pain, and has high patient acceptance; (3) patient trust and acceptance of traditional Chinese medicine.

From the above results, it is known that the present invention has definite therapeutic effects on this type of patients, and specifically, how to treat the present disease by what mechanism of action needs further exploration.

4 clinical cases

Case 1:

li Mou, female, age 36, complaint: the right facial part repeatedly developed flat papules for 3+ years.

Etiology of patient: no obvious cause exists on the right face part before 3+ years, brown flat pimples with different sizes and clear boundaries are scattered, and itching is sometimes caused, and the people are not paid attention to and diagnosed for a long time. The user can visit the clinic of our hospital for playing the game. The following symptoms are shown in the following formula: the right face is seen as brown flat pimples with needle points up to mung bean size. The people feel weak after plain activities, can eat and feel averse to cold and averse to cold, have cold hands and feet, regulate urine and stool, sleep poorly, pale and dark tongue with white and greasy coating, and wiry and thready pulse. Past history of: no special is provided. History of menstruation: the menstrual blood is a kind of 13 year old, the menstrual blood is a little, and there is a blood clot. Checking: no abnormality was seen. Special examination: the right face is seen with a plurality of needle points to the green bean brown flat pimple with hard texture.

Diagnosis of traditional Chinese medicine: flat wart; syndrome type: yang deficiency and congealing cold, qi and blood disharmony with exogenous toxin.

Western diagnosis: flat wart.

Prescription: prescription for warming yang and removing wart.

The traditional Chinese medicine is taken orally: 10g of aconite, 15g of cassia twig, 15g of scouring rush, 15g of beautiful sweetgum fruit, 10g of peach kernel, 10g of safflower, 10g of red paeony root, 15g of angelica, 9g of szechuan lovage rhizome, 20g of white paeony root, 15g of honeysuckle flower, 25g of weeping forsythiae capsule, 15g of common selfheal fruit-spike, 15g of Chinese thorowax root, 30g of coix seed, 12g of Indian buead, 20g of membranous milkvetch root, 15g of tangerine peel, 10g of cape jasmine, 10g of platycodon root, 9g of almond and 10 doses.

The using method comprises the following steps: decocting with water for oral administration, one dose per day (taken in three times);

and (5) re-diagnosis: after 10 doses of the medicine are taken continuously, the rash is partially resolved, the color is light, and the itching is obviously relieved. The hypodynamia, the cold feeling and the sleep are improved before, and the hands and feet are warmed before.

Review prescriptions: the prescription is continuously used for enhancing treatment of the front 15 doses, the prescription is unchanged, and the use method is the same as the previous one.

And re-diagnosis is carried out after 15 doses of continuous administration: the face on the right side is scattered on a plurality of pale brown spots, has no itching feeling, does not feel cold, is obviously improved before being used for treating hypodynamia, aversion to cold and sleeping, is obviously warmed up in hands and feet, is light in dysmenorrhea degree, is increased before being used for treating the menstrual pain, is slightly pale in color and is less in blood clot than the prior art, and 5 doses are taken for consolidating curative effects.

Case 2:

wang Mou men, 21 years old, complaints: the facial and cervical multiple flattened papules were repeated for 2 years.

Etiology of patient: since the study was frequently performed overnight 2 years ago, the patients were not expected to pay attention to the fact that the patients were inadvertently found to have flat pimples with a similar needle size scattered on the face and neck, and no symptoms were found. The rash then increased gradually, darkened in color, and was even slightly itchy. This time, the beauty is affected, and the patient is treated. The following symptoms: the face and neck part is seen as flat pimple from brown needle point to soybean size, and has smooth surface, poor appetite, aversion to cold, listlessness, cold hands and feet, clear and long urine and normal stool. A pale and dark tongue with a white or slippery coating and a deep, thready and weak pulse.

Diagnosis of traditional Chinese medicine: flat wart; syndrome type: yang deficiency and congealing cold, qi and blood disharmony with exogenous toxin.

Western diagnosis: flat wart.

Prescription: prescription for warming yang and removing wart.

The traditional Chinese medicine is taken orally: 10g of aconite, 15g of cassia twig, 15g of scouring rush, 15g of beautiful sweetgum fruit, 10g of peach kernel, 10g of safflower, 10g of red paeony root, 15g of angelica, 9g of szechuan lovage rhizome, 20g of white paeony root, 15g of honeysuckle flower, 25g of weeping forsythiae capsule, 15g of common selfheal fruit-spike, 15g of Chinese thorowax root, 30g of coix seed, 12g of Indian buead, 20g of membranous milkvetch root, 15g of tangerine peel, 10g of cape jasmine, 10g of platycodon root, 9g of almond and 7 doses.

The using method comprises the following steps: decocting with water for oral administration, one dose per day (taken in three times);

and (5) re-diagnosis: after 7 doses of the medicine are taken continuously, the rash is mostly resolved, the color of the rash is light, and the itching is not complained. Poor appetite, aversion to cold, mental fatigue and weakness are all improved before, and hands and feet are warmed before.

Review prescriptions: because patients learn to require multiple medicines, the recipe is effective in taking medicines, the effect is not more than that of taking medicines, 20 doses in front of the recipe are continued, the recipe is unchanged, and the use method is the same as before.

After follow-up, the patient expresses that the face and neck rash is basically resolved, and the symptoms of listlessness, diet, aversion to cold and cold hands and feet are obviously improved.

Detailed Description

The invention is further illustrated by the following examples, which are not intended to be limiting.

Example 1.

Prescription: is prepared from radix aconiti carmichaeli 100g, cassia twig 150g, scouring rush 150g, fructus liquidambaris, peach kernel 100g, safflower 100g, red paeony root 100g, angelica 150g, ligusticum wallichii 90g, white paeony root 200g, honeysuckle 150g, weeping forsythiae capsule 250g, selfheal 150g, bupleurum root 150g, coix seed 300g, poria cocos wolf 120g, astragalus root 200g, dried orange peel 150g, cape jasmine 100g, balloonflower 100g and almond 90 g.

Is prepared.

The process comprises the following steps: weighing the medicinal materials according to the prescription proportion, adding 10 times of water, boiling, refluxing and extracting for 3 times, 1 hour each time, combining three extracting solutions, uniformly mixing, concentrating into 70% of the original medicinal liquid, filtering while the hot, concentrating the filtrate into extract with relative density of 1.20-1.25 at 80 ℃, continuously heating with slow fire to obtain the extract, and filling into a sterile bottle when a small amount of extract can be flatly pulled into filaments or dripped on paper without water marks, and sealing to obtain the extract.

The usage amount is as follows: is taken once a day, 30g once in the morning and evening.

Example 2.

Prescription: is prepared from radix aconiti carmichaeli 50g, cassia twig 100g, scouring rush 100g, fructus liquidambaris 100g, peach kernel 50g, safflower 50g, red paeony root 50g, angelica 100g, ligusticum wallichii 40g, white paeony root 150g, honeysuckle 100g, weeping forsythiae capsule 180g, selfheal 100g, bupleurum 100g, coix seed 200g, poria cocos 70g, astragalus root 150g, dried orange peel 100g, cape jasmine 50g, balloonflower 50g and almond 40 g.

The process comprises the following steps: weighing the medicinal materials according to the prescription proportion, adding 8 times of water, boiling, refluxing and extracting for 2 times, each time for 2 hours, mixing the two extracting solutions, uniformly mixing, concentrating into 70% of the original medicinal liquid, filtering while the medicinal liquid is hot, concentrating the filtrate into extract with relative density of 1.20-1.25 at 80 ℃, drying the extract into dry extract at 80 ℃, pulverizing into fine powder, adding starch with the preparation amount of 5%, uniformly mixing, granulating with 80% of ethanol, drying, granulating, and filling into capsules to obtain the capsule.

The usage amount is as follows: is taken once a day, 30g once in the morning and evening.

Example 3.

Prescription: is prepared from 150g of aconite, 200g of cassia twig, 200g of scouring rush, 200g of fructus liquidambaris, 150g of peach kernel, 150g of safflower, 150g of red paeony root, 200g of angelica, 130g of szechuan lovage rhizome, 250g of white paeony root, 200g of honeysuckle flower, 320g of weeping forsythiae capsule, 200g of common selfheal fruit-spike, 200g of Chinese thorowax root, 400g of coix seed, 170g of Indian buead, 250g of membranous milkvetch root, 200g of tangerine peel, 150g of cape jasmine, 150g of platycodon root and 130g of almond.

The process comprises the following steps: weighing the medicinal materials according to the prescription proportion, adding 12 times of water, boiling, refluxing and extracting for 2 times, 1.5 hours each time, combining the two extracting solutions, uniformly mixing, concentrating into 70% of the original medicinal liquid, filtering while the hot, concentrating the filtrate into extract with relative density of 1.15-1.20 at 80 ℃, drying the extract into dry extract at 80 ℃, crushing the dry extract into fine powder to obtain dry extract, taking the dry extract, adding 10% of pregelatinized starch, uniformly mixing, granulating with 75% of ethanol as a wetting agent, drying, tabletting, and coating with a film to obtain the tablet.

The usage amount is as follows: is taken once a day, 30g once in the morning and evening.

Example 4.

Prescription: is prepared from radix aconiti carmichaeli 100g, cassia twig 200g, scouring rush 100g, liquidambar formosana hance 170g, peach kernel 60g, safflower 70g, red paeony root 120g, angelica 200g, ligusticum wallichii 40g, white paeony root 250g, honeysuckle 150g, weeping forsythiae capsule 300g, selfheal 110g, bupleurum root 150g, coix seed 300g, poria 150g, astragalus root 170g, dried orange peel 180g, gardenia 50g, balloonflower root 150g and almond 100 g.

The process comprises the following steps: weighing the medicinal materials according to the prescription proportion, adding 6 times of water, boiling, refluxing and extracting for 3 times, 1.5 hours each time, merging the three extracting solutions, uniformly mixing, concentrating into 80% of the original medicinal liquid, filtering while the hot, concentrating the filtrate into extract with relative density of 1.15-1.20 at 80 ℃, drying the extract at 80 ℃, crushing into fine powder to obtain dry extract, taking 1 part of dry extract, 1 part of sucrose, preparing particles by a wet method, drying at 80 ℃, sieving for 1 time by a 16-mesh sieve, and sieving the fine powder by a 60-mesh sieve to obtain the granules.

The usage amount is as follows: is taken once a day, 30g once in the morning and evening.

Example 5.

Prescription: is prepared from 150g of aconite, 200g of cassia twig, 150g of scouring rush, 100g of beautiful sweetgum fruit, 50g of peach kernel, 100g of safflower, 80g of red paeony root, 180g of Chinese angelica, 70g of szechuan lovage rhizome, 190g of white paeony root, 200g of honeysuckle flower, 320g of weeping forsythiae capsule, 100g of common selfheal fruit-spike, 100g of Chinese thorowax root, 350g of coix seed, 90g of Indian buead, 200g of membranous milkvetch root, 180g of tangerine peel, 50g of cape jasmine, 90g of platycodon root and 80g of almond.

The process comprises the following steps: weighing the medicinal materials according to the prescription proportion, adding 6 times of water, boiling, refluxing and extracting for 3 times, 1.5 hours each time, merging the three extracting solutions, uniformly mixing, concentrating into 80% of the original medicinal liquid, filtering while the hot, concentrating the filtrate into extract with relative density of 1.15-1.20 at 80 ℃, drying the extract at 80 ℃, crushing into fine powder to obtain dry extract, taking 1 part of dry extract, 1 part of sucrose, preparing particles by a wet method, drying at 80 ℃, sieving for 1 time by a 16-mesh sieve, and sieving the fine powder by a 60-mesh sieve to obtain the granules.

The usage amount is as follows: is taken once a day, 30g once in the morning and evening.

Example 6.

Prescription: is prepared from 120g of aconite, 180g of cassia twig, 200g of scouring rush, 200g of fructus liquidambaris, 50g of peach kernel, 55g of safflower, 100g of red paeony root, 180g of angelica, 90g of szechuan lovage rhizome, 200g of white paeony root, 120g of honeysuckle, 180g of weeping forsythia, 200g of selfheal, 150g of bupleurum, 250g of coix seed, 80g of poria cocos, 150g of astragalus root, 200g of dried orange peel, 80g of gardenia, 140g of platycodon root and 100g of almond.

The process comprises the following steps: weighing the medicinal materials according to the prescription proportion, adding 10 times of water, boiling, refluxing and extracting for 3 times, 1 hour each time, combining three extracting solutions, uniformly mixing, concentrating into 70% of the original medicinal liquid, filtering while the hot, concentrating the filtrate into extract with relative density of 1.20-1.25 at 80 ℃, continuously heating with slow fire to obtain the extract, and filling into a sterile bottle when a small amount of extract can be flatly pulled into filaments or dripped on paper without water marks, and sealing to obtain the extract.

The usage amount is as follows: is taken once a day, 30g once in the morning and evening.

Claims (10)

1. A medicament for treating flat warts, which is characterized in that: the medicinal active ingredients of the composition are calculated according to the weight components: is prepared from radix aconiti carmichaeli 50-150 parts, cassia twig 100-200 parts, scouring rush 100-200 parts, fructus liquidambaris, peach kernel 50-150 parts, safflower 50-150 parts, red peony root 50-150 parts, chinese angelica 100-200 parts, ligusticum wallichii 40-130 parts, white peony root 150-250 parts, honeysuckle 100-200 parts, capsule of weeping forsythiae 180-320 parts, selfheal 100-200 parts, bupleurum 100-200 parts, coix seed 200-400 parts, poria cocos 70-170 parts, astragalus root 150-250 parts, dried orange peel 100-200 parts, cape jasmine 50-150 parts, balloonflower 50-150 parts and almond 40-130 parts.

2. The medicament for treating flat wart according to claim 1, wherein: the medicinal active ingredients of the composition are calculated according to the weight components: is prepared from 80-120 parts of aconite, 120-180 parts of cassia twig, 120-180 parts of scouring rush, 120-180 parts of fructus liquidambaris, 80-120 parts of peach kernel, 80-120 parts of safflower, 80-120 parts of red paeony root, 120-180 parts of angelica, 70-110 parts of szechuan lovage rhizome, 170-230 parts of white paeony root, 120-180 parts of honeysuckle, 200-300 parts of weeping forsythiae capsule, 120-180 parts of common selfheal fruit-spike, 120-180 parts of Chinese thorowax root, 250-350 parts of coix seed, 100-140 parts of Indian buead, 170-230 parts of membranous milkvetch root, 120-180 parts of tangerine peel, 80-120 parts of cape jasmine, 80-120 parts of platycodon root and 70-110 parts of almond.

3. A medicament for the treatment of flat warts as claimed in claim 1 or 2, characterized in that: the medicinal active ingredients of the composition are calculated according to the weight components: is prepared from 100 parts of aconite, 150 parts of cassia twig, 150 parts of scouring rush, 150 parts of fructus liquidambaris, 100 parts of peach kernel, 100 parts of safflower, 100 parts of red paeony root, 150 parts of angelica, 90 parts of szechuan lovage rhizome, 200 parts of white paeony root, 150 parts of honeysuckle flower, 250 parts of weeping forsythiae capsule, 150 parts of common selfheal fruit-spike, 150 parts of Chinese thorowax root, 300 parts of coix seed, 120 parts of Indian buead, 200 parts of membranous milkvetch root, 150 parts of tangerine peel, 100 parts of cape jasmine, 100 parts of platycodon root and 90 parts of almond.

4. A method for preparing a medicament for treating flat warts according to any one of claims 1-3, characterized in that: all the medicinal materials are weighed according to the proportion, and processed according to the conventional preparation method to prepare the corresponding medicinal preparation.

5. The method for preparing the medicine for treating flat wart according to claim 4, wherein: all the medicinal materials are weighed according to the proportion, crushed and uniformly mixed, water is added for decoction to obtain decoction, and the decoction is processed according to the conventional preparation method to prepare the corresponding medicinal preparation.

6. The method for preparing the medicine for treating flat wart according to claim 5, wherein: the medicinal preparation comprises a soft extract, a capsule, a tablet and a granule.

7. The method for preparing the medicine for treating flat wart according to claim 6, wherein: the decoction is prepared by the following steps: weighing the medicinal materials according to the prescription proportion, adding 10 times of water, boiling, refluxing and extracting for 3 times, 1 hour each time, combining three times of extracting solutions, uniformly mixing, concentrating into 70% of the original medicinal liquid, filtering while the hot, concentrating the filtrate into extract with relative density of 1.20-1.25 at 80 ℃, continuously heating with slow fire to obtain the extract, and filling into a sterile bottle when a small amount of extract can be flatly pulled into filaments or dripped on paper without water marks.

8. The method for preparing the medicine for treating flat wart according to claim 6, wherein: the capsules were prepared as follows: weighing the medicinal materials according to the prescription proportion, adding 8 times of water, boiling, refluxing and extracting for 2 times, each time for 2 hours, mixing the two extracting solutions, uniformly mixing, concentrating into 70% of the original medicinal liquid, filtering while the medicinal liquid is hot, concentrating the filtrate into extract with relative density of 1.20-1.25 at 80 ℃, drying the extract into dry extract at 80 ℃, pulverizing into fine powder, adding starch with the preparation amount of 5%, uniformly mixing, granulating with 80% of ethanol, drying, granulating, and filling into capsules to obtain the traditional Chinese medicine.

9. The method for preparing the medicine for treating flat wart according to claim 6, wherein: the tablets were prepared as follows: weighing the medicinal materials according to the prescription proportion, adding 12 times of water, boiling, refluxing and extracting for 2 times, 1.5 hours each time, combining the two extracting solutions, uniformly mixing, concentrating into 70% of the original medicinal liquid, filtering while the hot, concentrating the filtrate into extract with relative density of 1.15-1.20 at 80 ℃, drying the extract into dry extract at 80 ℃, crushing the dry extract into fine powder to obtain dry extract, taking the dry extract, adding 10% of pregelatinized starch, uniformly mixing, granulating with 75% of ethanol as a wetting agent, drying, tabletting and film coating to obtain the traditional Chinese medicine.

10. The method for preparing the medicine for treating flat wart according to claim 6, wherein: the granule is prepared by the following steps: weighing the medicinal materials according to the prescription proportion, adding 6 times of water, boiling, refluxing and extracting for 3 times, 1.5 hours each time, merging the three extracting solutions, uniformly mixing, concentrating into 80% of the original medicinal liquid, filtering while the hot, concentrating the filtrate into extract with relative density of 1.15-1.20 at 80 ℃, drying the extract at 80 ℃, crushing the extract into fine powder to obtain dry extract, taking 1 part of dry extract, 1 part of sucrose, preparing particles by a wet method, drying at 80 ℃, sieving for 1 time by a 16-mesh sieve, and sieving the fine powder by a 60-mesh sieve to obtain the finished product.