CN116492427A - 一种治疗癫痫的药物 - Google Patents
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开一种治疗癫痫的药物,其包括第一药物组合物和第二药物组合物,第一药物组合物和第二药物组合物配合使用;所述第一药物组合物由赤芍、川芎、红花、胆星、五灵脂、地龙、天麻、当归、党参、甘松、桃仁、葛根、全蝎组成,第二药物组合物由鹿胶、龟板、当归、枣仁、山药、茯苓、人参、黄芪、白术、金毛狗脊、熟地、枸杞、紫河车组成,本发明根据癫痫的病因病机,以急则治其标,缓则治基本,标本兼治的基本原则,采用第一药物组合物和第二药物组合物配合,先以豁痰化瘀,通络开窍,镇痉熄风,养血安神的第一药物组合物,控制癫痫病症发生,再以峻补精神气血先天禀赋及调理后天脾胃失调的第二药物组合物,防止癫痫病的复发,实现标本兼治。
Description
技术领域
本发明涉及药物技术领域,尤其涉及一种治疗癫痫的药物。
背景技术
癫痫俗称“羊角风”,是一种由多种病因引起的脑部疾病,其发病机制为大脑因脑部神经元出现突发性异常放电导致短时间的功能障碍,临床表现为发作性、短暂性、重复性和刻板性的特点。癫痛的治疗方法主要有药物治疗、手术治疗、电刺激治疗等,但是目前药物治疗仍处于主导地位,而药物治疗多以西药为主,西药只能缓解表面症状,毒副作用很大,且病情反复发作,例如丙戊酸副作用有体重增加,慢性认知,记忆,行为改变,少数有严重的肝毒作用,可能出现胰腺炎等;苯巴比妥有镇静副作用,偶可引起结缔组织损伤,有戒断反应,有致畸作用;乙琥胺偶有胃肠道反应等,有些患者副作用,会因不能耐受而导致中断,疗效不理想。手术会造成不可逆的后遗症;中医癫痫病方较多,但还没有短期服药达到长期控制病情复发疗效的中药。
发明内容
因此,针对以上不足,本发明提供一种治疗癫痫的药物,合理配伍,以急则治其标,缓则治其本,标本兼治的基本原则,采用第一药物组合物和第二药物组合物配合,先以豁痰化瘀,通络开窍,镇痉熄风,养血安神的第一药物组合物,控制癫痫病症发生,再以峻补精神气血先天禀赋及调理后天脾胃失调的第二药物组合物,防止癫痫病的复发,实现标本兼治。
本发明的技术方案如下:
一种治疗癫痫的药物,其包括第一药物组合物和第二药物组合物,第一药物组合物和第二药物组合物配合使用;
按重量计,所述第一药物组合物由以下原料组成:
赤芍5-15份、川芎5-15份、红花5-15份、胆星5-25份、五灵脂5-15份、地龙5-15份、天麻5-25份、当归5-25份、党参5-25份、甘松5-15份、桃仁5-15份、葛根5-15份、全蝎5-15份;
按重量计,所述第二药物组合物由以下原料组成:
鹿胶30-150份、龟板30-150份、当归30-80份、枣仁30-80份、山药30-80份、茯苓30-80份、人参30-80份、黄芪30-80份、白术30-80份、金毛狗脊150-550份、熟地30-150份、枸杞60-150份、紫河车150-550份。
优选地,按重量计,所述第一药物组合物由以下原料组成:
赤芍10份、川芎10份、红花5份、胆星20份、五灵脂15份、地龙10份、天麻20份、当归20份、党参20份、甘松10份、桃仁10份、葛根10份、全蝎6份。
优选地,按重量计,所述第二药物组合物由以下原料组成:
鹿胶100份、龟板100份、当归60份、枣仁60份、山药60份、茯苓60份、人参60份、黄芪60份、白术60份、金毛狗脊300份、熟地100份、枸杞100份、紫河车300份。
优选地,所述第一药物组合物为口服煎煮剂,所述第二药物组合物为蜜丸剂。
传统中医学认为癫痫的发病的病灶虽位于脑,但病性属于本虚表实,上盛下虚之证,以风、热、痰、瘀、虚为主要病理因素,邪痹脑窍,元神失控是疾病的关键,即癫痫是由于正气亏虚,脏腑的功能低下,导致淤血、痰浊、火热和内风动越等病理改变所引起;《医学纲目·癫痫》中认为“癫痫者,痰邪逆上也”,痰邪可导致脉道闭塞,孔窍不通而发病,此外瘀血内停,阻滞心窍也可引起痫证发作。痫证的主要特点为起病突然,反复发作。其以风痰瘀虚为主要病理因素。
根据癫痫的发病机制,中医治疗需分清标本,发作时宜先治标,发作间期治本为主,即以急则治其标,缓则治其本原则,因此本发明在癫痫症发作期间,先以第一中药组合物,达以豁痰化瘀,通络开窍,镇痉熄风,养血安神,控制癫痫病症发生,再以第二组合物,达峻补精神气血,补先天禀赋不足,调理后天脾胃失养,扶正祛邪,防止癫痫病的复发,达到标本兼治。
本发明的第一药物组合物的组方以桃红四物汤为基础,去熟地,加胆星、地龙、葛根、天麻、甘松、党参、五灵脂、全蝎;
本发明的第一药物组合物以桃仁、红花、当归、赤芍、川芎为君药:当归补血主药,润澡通经,帅众血药袪各经瘀血;红花轻扬入脑,为行血要药;桃仁杀虫治血痰,伍红花增强行血化瘀;川芎生气而生血为血中气药,引人身清轻之气上行于脑;赤芍逐血导瘀,破积泄降,保持气血升降平衡,共达补血活血、逐瘀之功;
以党参、天麻、胆星、地龙、五灵脂为臣药:党参补气活血推动痰瘀化散;天麻镇痉熄风,营养脑组织;胆星涤痰、除痰痹;地龙熄风止痉清热破结,引药入脑药;五灵脂化瘀血,取其腥秽直入脑部攻痰涎挟血成窠的病根,除血痹,以助君药化瘀除痰痹;
佐以全蝎、葛根、甘松,全蝎通络散结解毒熄风;葛根升阳生津引药从督脉入脑,反佐平衡众温药;甘松开郁散结,香窜以开脑窍。
第二药物组合物中以紫河车、金毛狗脊为君,其中紫河车大补气血,金毛狗脊驱逐风寒湿诸痹外邪,其中风寒湿等外邪侵入既是致病因素,又是诱病因素,以峻补精神气血,补先天禀赋不足;
以鹿胶、龟板、人参、枸杞为臣,其中鹿胶通督脉,壮元阳、生精髓、大补气血;龟板通任脉,滋阴潜阳;人参大补元气、固脱生津、安神益智;枸杞滋肾润肺补肝,助君药峻补精神气血,提高外邪抵抗力;
佐以熟地补精,黄芪补气,当归补血,加强君臣药的补益精气血的效力,以固先天之本;
再佐以白术、茯苓、山药健运脾胃,以固后天之本;
再佐以酸枣仁安五脏,宁心安神。各药共同作用,以达到调理人体脏腑经络气血,兼顾先后天之本,标本兼治,达到祛邪补正,阴阳平衡的效果,终可标本兼治,防止癫痫病的复发。
具体实施方式
现将详细地提供本发明实施方式的参考,其一个或多个实例描述于下文。提供每一实例作为解释而非限制本发明。实际上,对本领域技术人员而言,显而易见的是,可以对本发明进行多种修改和变化而不背离本发明的范围或精神。例如,作为一个实施方式的部分而说明或描述的特征可以用于另一实施方式中,来产生更进一步的实施方式。
因此,旨在本发明覆盖落入所附权利要求的范围及其等同范围中的此类修改和变化。本发明的其它对象、特征和方面公开于以下详细描述中或从中是显而易见的。本领域普通技术人员应理解本讨论仅是示例性实施方式的描述,而非意在限制本发明更广阔的方面。下面结合实施例对本发明做进一步说明。
本发明的第一药物组合物和第二药物组合物的原料药的药理如下:
所述第一药物组合物:
桃仁:味苦,性甘平,归心肝大肠经,功能:活血袪瘀,润肠通便。主治:治经闭症瘕,热病蓄血,风痹疟疾,跌打损伤,瘀血肿痛,血燥便秘,杀虫治血痰,治高血压。
红花:味辛,性温,归心肝经,功能:活血通经,袪瘀止痛。主治:血瘀经闭痛经,产后瘀滞腹痛等症;症瘕积聚,心腹瘀痛及跌打损伤,血脉闭塞,紫肿疼痛等症;斑疹色暗,热郁血瘀能活血化斑,凉血解毒;有活血行血和血生血之功,为行血之要药。
当归:味甘辛,性温,归肝心脾经。功能:补血活血,调经止痛,润燥滑肠,主血虚诸症。主治:月经不调,经闭痛经,崩漏,症瘕结聚,虚寒腹痛,肠燥便难,痿痹,肌肤麻木,赤痢后重,痈疽疮疡,跌打损伤。
赤芍:味苦,性微寒,归肝经;功能:逐血导瘀,破积泄降。主治:热入营血,斑疹吐衄,经闭症瘕,跌打损伤,痈肿疮毒,目赤翳障。
川芎:味辛,性温,归肝胆心胞经,功能:活血行气,袪风止痛。主治:血瘀气郁痛证,头痛,风湿痹痛,生气而生血为血中气药神验,引人身清轻之气上行于脑。
党参:性平,味甘、微酸。归脾、肺经。功能主治补中补中,益气,生津。治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。
天麻:性辛、温、无毒,归肝经。有抗癫痫,抗悸厥,抗风湿;镇静,镇痉,镇痛,补虚,平肝息风的功效。多用于头痛眩晕、肢体麻木、小儿惊风、癫痫、抽搐、破伤风等症,且临床应用证明,其对血管性神经性头痛、脑震荡后遗症等有显著疗效。
胆星:味苦、辛,性凉,归肝、胆、肺经。清热化痰,熄内定惊。用于治疗中风患者出现的头昏、手足麻木的病症。利气燥湿化痰,为中风涤痰汤主药。
地龙:性味咸、寒,归肝、脾、膀胱经。具有清热息风、平喘的功效,用于治疗壮热、躁狂、惊痫抽搐、癫痫、肺热咳喘、百日咳、风湿热痹、风寒湿痹、中风后半身不遂、骨折肿痛、热结膀胱、砂石淋证等。
五灵脂:味苦甘辛,归肝脾经。功能:行血止血止痛。治心腹血气诸痛,妇女经闭,产后瘀血作痛;治妇女血崩,经水过多,赤带不绝。止妇人经水过多,赤带不绝,胎前产后,血气诸痛;男女一切心腹、胁肋,少腹诸痛,疝痛,血痢、肠风腹痛;身体血痹刺痛,肝疟发寒热,反胃,消渴及痰涎挟血成窠,血贯疃子,血凝齿痛,重舌,小儿惊风,五痫,癫疾;杀虫,解药毒及蛇蝎蜈蚣伤。损伤接,骨涂敷疮疥。
全蝎:性味咸,微温。有毒,归肝经。具有息风止痉,解毒散结,通络止痛的功效。用于急慢惊风,中风口眼歪斜以及破伤风等疾病。全蝎的解毒散结的作用,用于恶疮肿毒,常常做成膏剂外用。全蝎的通络止痛的作用,常常用于比较顽固的偏头痛,风湿痹痛等。
葛根:性味甘、辛、凉,入脾、胃经,具有发表解肌、升阳透疹、生津止泻,用于外感发热头痛、高血压颈项强痛、口渴、消渴、麻疹不透、热痢、泄泻。葛根素,黄酮类化合物能降低血清胆固醇,降低油三酯治疗高血糖,高血脂病症,有显著疗效。葛根醇提取物能显著对抗东度警碱所致的记忆障碍,治疗老年性痴呆,智力障碍,记忆力差等病症。
甘松:味辛、甘,温。归脾、胃经。有行气止痛,开郁醒脾之功效,用于思虑伤脾或寒郁气滞引起的胸闷腹胀、不思饮食及胃脘疼痛等证。
所述第二药物组合物:
紫河车:《景岳全书》味甘咸,性温,归五脏经。大补气血,能补男妇一切虚损,尤治癫痫失志,精神短少,怔忡惊悸,肌肉羸瘦,不孕不育,痨瘵传尸。现代药理研究表明:紫河车含有多种抗体,有抑制多种病毒对人细胞的作用;含有多种激素、多种有应用价值的酶。临床应用凡是先天禀赋不足者必用之。
金毛狗脊:味甘苦,性温,入肝肾经。《神农本草经》:主腰背强,机关缓急,周痹寒湿,膝痛。颇利老人。《别录》:坚脊,利俯仰、止血。属强壮筋骨药,对筋骨不健的病证有治疗和保健的双重作用。除人体易受之风寒湿痹,主治腰脊强痛,不能俯仰,足膝软弱及风湿腰痛等症,有温补固摄止血作用,治疗尿频、遗尿,遗精,带下,半身不遂,口眼呙斜等,以及治疗骨瘤、骨肉瘤、颅内肿瘤、骨髓瘤等多种肿瘤等。金毛狗脊化学成分含有淀粉,鞣质,挥发油、蕨素类物质、水溶性酚酸类化合物、糖及糖苷类化合物,及其氨基酸,无机元素等化学成分。另金毛狗脊含有强心苷、蒽醌、三萜、内酯等类成分,研究证明,这些化合物也有极强的药理活性:防治骨质疏松,抑制血小板聚集,止血镇痛抑菌抗炎抗风湿抗氧化抗癌保肝。
鹿胶:《神农草本经》将其列为上品,名“白胶”,又名“鹿胶”,味甘、平,无毒,入肝、肾经。具有壮元阳、补气血、生精髓、暖筋骨的作用。治疗各种虚损、劳伤。
龟板:味甘、咸,性寒,归肝、肾、心经,具有滋阴潜阳,益肾健骨,固经止崩的作用。可用于治疗阴虚火旺导致的骨蒸潮热、盗汗;阴虚阳亢导致的头目眩晕;热邪伤阴,虚风内动导致的肢体抖动;肝肾亏虚导致的腰膝软弱,筋骨不健以及小儿囟门不合;阴虚血热导致的月经过多,崩漏带下以及心烦失眠健忘。
人参:补气、固脱、生津、安神益智。人参,味甘微苦,性温平,可以入脾经、肺经、心经,具有补气、固脱、生津、安神益智的作用。为强壮滋补药,适用于调整血压、恢复心脏功能、神经衰弱及身体虚弱等症,也有祛痰、健胃、利尿、兴奋等功效。人参大补元气,为治疗虚劳内伤的第一要药,凡是大出血、大汗、大吐、大泻导致的元气损伤皆能挽救。
枸杞:味甘,性平。入肝、肾经。滋肾,润肺,补肝,明目。治肝肾阴亏,腰膝酸软,头晕,目眩,目昏多泪,虚劳咳嗽,消渴,遗精。现代药理研究表明:枸杞中所含的枸杞多糖有调节机体免疫作用,有抗癌抗肿瘤抗衰老抗疲劳抗辐射伤害,降血脂血糖,所含的氨基酸、类胡萝卜素、微量元素,维生素,生物碱都发挥着重要作用。临床应用中调肾阴肾阳组方皆可用之。
熟地:味甘,性微温,入足三阴经。《本草纲目》填骨髓,长肌肉,生精血,补五脏、内伤不足,通血脉,利耳目,黑须发,男子五劳七伤,女子伤中胞漏,经候不调,胎产百病。现代药理研究表明:熟地有延缓小鼠衰老、改善小鼠阴虚、血细胞产生作用。临床应用凡是先天禀赋不足者必用之。
黄芪:味甘,性微温,归肝脾经。首载《神农本草经》有补气升阳、固表止汗、利水消肿、养津生血、行滞通痹、托毒排脓、敛疮生肌的功效。用于气少乏力,食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿,内热消渴、血虚萎黄、半身不遂、痹痛麻木、痈疽难溃,久溃不敛。研究表明黄芪的化学成分主要为多种黄酮类和三萜皂苷类化合物,单糖,多糖,氨基酸,微量元素,维生素等。具有增强免疫糸统功能,抗心肌缺血,双向调节血压,保护血管内皮细胞、保肝、降血糖、抗病毒、抗肿瘤,清除自由基和抗衰老等作用。另其可促进DA能神经元生长,提高记忆力,改善大脑退行性病变;保护糖尿病患者坐骨神经,防止神经脱髓鞘;对大脑的血管神经起到重要的保护作用。
当归:味甘辛,性温,归肝心脾经。功能:补血活血,调经止痛,润燥滑肠,主血虚诸症。主治:月经不调,经闭痛经,崩漏,症瘕结聚,虚寒腹痛,肠燥便难,痿痹,肌肤麻木,赤痢后重,痈疽疮疡,跌打损伤。
白术:味甘苦,性温,归脾胃经。主治:补气健脾,治疗脾胃气虚证;燥湿利水,治疗水肿、痰饮证;
止汗,治疗气虚自汗证;安胎,治疗胎动不安证。主要化学成分有挥发油,白术内脂,谷氨酸等14种氨基酸及树脂、vita、多糖等物质。研究表明白术具有利尿、抗肿瘤、抗菌抗炎、抗衰老等作用,对神经系统、消化道、子宫平滑肌有一定作用,能调节免疫功能。
茯苓:味甘淡,性平,归心、肺、脾经。具有渗湿利水,健脾和胃,宁心安神的功效。所含茯苓酸具有增强免疫力、抗肿瘤以及镇静、降血糖等的作用。可松弛消化道平滑肌,抑制胃酸分泌,防止肝细胞坏死,抗菌等功效。
山药:性味甘、平,归于脾、肺、肾。山药含有丰富的淀粉酶、多酚氧化酶等物质,该物质有健脾益胃、补肾的功效,通常用于治疗脾胃虚弱、腹泻和其它症状;山药含有皂甙、黏液质,具有滑润滋润的功效,因此其有益于肺气虚弱,能够滋补肺阴,临床上肺气不足、长期咳嗽的病人可以食用;山药含有黏液蛋白,具有生精之功效,可以降血糖,临床上配伍可以治疗糖尿病,效果较好;山药含有丰富的黏液蛋白、维生素和微量元素,以上物质可以很好的抑制血脂在血管壁上的沉积,从而预防心脑血管疾病,可以起到延年益寿的作用。
酸枣仁:味酸甘、性平,归于心、肝、胆经。其功效与作用为:安五脏、轻身延年,养肝宁心、安神敛汗,临床上一般用于神经衰弱、心烦失眠、多梦;有补肝肾、养心安神的功效,适合于女性更年期综合征、夜寐不安、面色潮红、耳鸣、头晕等病人;酸枣仁实验证明,其可以有效的改善心肌缺血,枣仁总皂甙有保护缺氧、缺糖和氯丙嗪所致的心肌损伤的功效,因此心脏功能衰弱、心脏病的病人可以配合使用;且现代药理研究桃红四物汤含有人体必需16种微量元素(除锡外),上微量元素是人体多酶系统的关键成分,对人体健康起到重要作用,对儿童生长发育有直接关系,可影响蛋白质、脂肪、糖的代谢以及内分泌腺的功能,影响遗传变异与致癌等。桃红四物汤补充和调节微量元素的功能可防止早衰和改善老年症状,影响脑功能。
实施例1:一种治疗癫痫的药物,其包括第一药物组合物和第二药物组合物,第一药物组合物和第二药物组合物配合使用;
按重量计,所述第一药物组合物由以下原料组成:
赤芍10克、川芎10克、红花5克、胆星20克、五灵脂15克、地龙10克、天麻20克、当归20克、党参20克、甘松10克、桃仁10克、葛根10克、全蝎6克。
按重量计,所述第二药物组合物由以下原料组成:
鹿胶100克、龟板100克、当归60克、枣仁60克、山药60克、茯苓60克、人参60克、黄芪60克、白术60克、金毛狗脊300克、熟地100克、枸杞100克、紫河车300克。
实施例2:一种治疗癫痫的药物,其包括第一药物组合物和第二药物组合物,第一药物组合物和第二药物组合物配合使用;
按重量计,所述第一药物组合物由以下原料组成:
赤芍15克、川芎15克、红花15克、胆星10克、五灵脂10克、地龙10克、天麻10克、当归10克、党参10克、甘松10克、桃仁15克、葛根15克、全蝎10克;
按重量计,所述第二药物组合物由以下原料组成:
鹿胶100克、龟板100克、当归60克、枣仁60克、山药60克、茯苓60克、人参60克、黄芪60克、白术60克、金毛狗脊300克、熟地100克、枸杞100克、紫河车300克。
实施例1和实施例2中的第一药物组合物为口服煎煮剂,第二药物组合物为蜜丸剂,上量组药均为一副。
实施例1和实施例2的使用方法为:
第一药物组合物每天一副药,水煎服,每副药煎服二次;
第二药物组合物。每日服二次,每次服10克,服完一副药后停药观察。
第一药物组合物,在病发期或未发期均可服用;待第一药物组合物服至病情连续一周或两周或三周未发时,接着服第二药物组合物。或第一药物组合物和第二药物组合物并服。
实施例3:临床疗效
选择60例来职工医院就诊的原发性癫痫的患者,其每天发作次数均≥1,其中男性34名,女性26名,年龄在15-52岁之间,平均年龄34.52±4.26岁,病程在2年内。将上患者分为两组,每组30人,分别为对照组和治疗组,两组患者的年龄、病程等均无显著性的差异。
对照组口服开浦兰(左乙拉西坦口服溶液,NextPharmaSAS(法国)生产),150ml:15g/瓶,每日服用1000ml,早晚各服用500ml;治疗组采用实施例1的水煎口服剂的第一药物组合物和蜜丸剂的第二药物组合物配合服用,待第一药物组合物服至连续一周未发作时,继服第二药物组合物,进行治疗。
连续治疗15周后始进行疗效统计。
疗效评价标准(根据国家中医药管理局脑病急症协作组起草制定的《癫痫诊断与疗效评定标准》
(试行)制定癫痫病疗效评定标准,维持期4周癫痫发作次数和每次发作持续时间。采用计分法,着眼于意识障碍及其持续时间,强直、抽搐的程度及持续时间,脑电图的变化,同时结合发作频率的变化判断疗效):
基本控制:疗效百分数>=70%,或<70%,发作频率减小75%;
显效:疗效百分数>=40%,而<70%,或发作频率减少75%;
有效:疗效百分数>=40%,而<70%,或发作频率减少50%;
无效:疗效百分数>=20%,或发作频率减少<25%。有效率=(基本控制+显效+有效)*100/总人数疗效结果显示:
对照组:基本控制0人,显效7人,有效12人,无效9人,有效率70.0%;
治疗组:基本控制2人,显效11人,有效15人,无效2人,有效率93.33%
实施例4:典型案例
案例1:邹某,男,17岁,十二岁发癫痫症,后确诊为原发性癫痫;2018年来就诊时:面青肢冷,声音怯弱,形体瘦弱,天生龟背,舌淡脉伏,问其病发,自诉癫痫发作三、五天,半月时间不等,发作时自感头痛头昏,目见闪电,倒地抽搐,流沫,移时自醒,醒后感头痛,心中烦闷难受。对其治疗,则以急则治其标,缓则治其本原则,先以口服煎剂第一药物组合物,以通窍活血,豁痰化瘀,镇痉养血,控制癫痫病症发生;然后再以蜜丸剂的第二药物组合物峻补精神气血,以补先天禀赋不足,防止癫痫病的复发,连续治疗12周后,无不良反应,无病发表现,后追访未再发病。
案例2:洪某,女,就诊时主诉:近两年会不定时突然无征兆昏倒在地,人事不清,约10分钟左右,人清醒后,感头痛头昏,心中烦闷难受,精神萎靡不振,其他无明显异常。发病间隔时间数月到半年不等。经细询:发病时确有流涎现象;且有二次咬破嘴唇舌尖,摔得头破血流,确诊患有癫痫。查:面色萎黄,声音不振,形体较廋弱,舌淡脉弱。先服第一药物组合物一周,无不良反应,无病发表现,其他无明显异常,续服第二药物组合物约80天,后追访未再发病。
案例3:刘某,男,41岁。就诊时主诉:患癫痫病17年,经服抗癫痫病西药控制大发作,但在服药期间仍有不定时间隔性癫痫症状发生:不定时突然无征兆昏倒在地,人事不清,口流涎沫,约10分钟——半小时左右,人清醒后,感头痛头昏,心中烦闷难受,精神萎靡不振。特别提到已不能行房事约7年,有轻生意向。经细询得知其有过轻中度的脑外伤史。查:面色晦暗,舌底静脉青紫瘀滞之像,舌质淡红,舌苔白略杂薄黄,脉虚软带涩滞。先服第一药物组合物一周,患者反应精神转好,食欲略增,嘱停服抗癫痫病西药。继服第一药物组合物二周,精神又转好,病无发作。继服第二药物组合物约80天,精神大为好转,能正常工作,病无发作。后追访6年,完全停服抗癫痫病西药病无发作,能与其妻正常同房。
案例4:蒋某,男,71岁,就诊时主诉:一年前不定时突然神志模糊,手抽搐不止。后发作时又增错觉、幻觉、不能回答家人的话。发作时会突然动作中断,两眼呆视,身抽动,摔打物品,有大小便失禁现象。经诊断,确诊为老年癫痫,闻名前来就诊。查:面色呈现病容白,舌底静脉青紫。舌质暗红,舌苔燥腻黄白相杂,脉略细而涩。先服第一药物组合物二周,病未见明显发作,精神好转。嘱停服其他药物,再服第一药物组合物二周,期间并服第二药物组合物二周,患者癫痫未再有发作,精神大为好转。追访3年未复发。
以上所述实施例的各技术特征可以进行任意的组合,为使描述简洁,未对上述实施例中的各个技术特征所有可能的组合都进行描述,然而,只要这些技术特征的组合不存在矛盾,都应当认为是本说明书记载的范围。
Claims (4)
1.一种治疗癫痫的药物,其特征在于,其包括第一药物组合物和第二药物组合物,第一药物组合物和第二药物组合物配合使用;
按重量计,所述第一药物组合物由以下原料组成:
赤芍5-15份、川芎5-15份、红花5-15份、胆星5-25份、五灵脂5-15份、地龙5-15份、天麻5-25份、当归5-25份、党参5-25份、甘松5-15份、桃仁5-15份、葛根5-15份、全蝎5-15份;
按重量计,所述第二药物组合物由以下原料组成:
鹿胶30-150份、龟板30-150份、当归30-80份、枣仁30-80份、山药30-80份、茯苓30-80份、人参30-80份、黄芪30-80份、白术30-80份、金毛狗脊150-550份、熟地30-150份、枸杞60-150份、紫河车150-550份。
2.根据权利要求1所述的一种治疗癫痫的药物,其特征在于,按重量计,所述第一药物组合物由以下原料组成:
赤芍10份、川芎10份、红花5份、胆星20份、五灵脂15份、地龙10份、天麻20份、当归20份、党参20份、甘松10份、桃仁10份、葛根10份、全蝎6份。
3.根据权利要求2所述的一种治疗癫痫的药物,其特征在于,按重量计,所述第二药物组合物由以下原料组成:
鹿胶100份、龟板100份、当归60份、枣仁60份、山药60份、茯苓60份、人参60份、黄芪60份、白术60份、金毛狗脊300份、熟地100份、枸杞100份、紫河车300份。
4.根据权利要求3所述的一种治疗癫痫的药物,其特征在于,所述第一药物组合物为口服煎煮剂,所述第二药物组合物为蜜丸剂。
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