CN116491502A - Long-acting antibacterial disinfectant and preparation method thereof - Google Patents
Long-acting antibacterial disinfectant and preparation method thereof Download PDFInfo
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 55
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 42
- 230000001954 sterilising effect Effects 0.000 claims abstract description 25
- 239000004480 active ingredient Substances 0.000 claims abstract description 20
- 239000002904 solvent Substances 0.000 claims abstract description 20
- 230000000149 penetrating effect Effects 0.000 claims abstract description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 30
- 239000011259 mixed solution Substances 0.000 claims description 20
- 239000012747 synergistic agent Substances 0.000 claims description 17
- 229910052757 nitrogen Inorganic materials 0.000 claims description 15
- 230000000845 anti-microbial effect Effects 0.000 claims description 10
- 238000011010 flushing procedure Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 102000016943 Muramidase Human genes 0.000 claims description 5
- 108010014251 Muramidase Proteins 0.000 claims description 5
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 5
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 229960000274 lysozyme Drugs 0.000 claims description 5
- 235000010335 lysozyme Nutrition 0.000 claims description 5
- 239000004325 lysozyme Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 229910000476 molybdenum oxide Inorganic materials 0.000 claims description 5
- BPCNEKWROYSOLT-UHFFFAOYSA-N n-phenylprop-2-enamide Chemical compound C=CC(=O)NC1=CC=CC=C1 BPCNEKWROYSOLT-UHFFFAOYSA-N 0.000 claims description 5
- PQQKPALAQIIWST-UHFFFAOYSA-N oxomolybdenum Chemical compound [Mo]=O PQQKPALAQIIWST-UHFFFAOYSA-N 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000008213 purified water Substances 0.000 claims description 5
- 239000000376 reactant Substances 0.000 claims description 5
- 238000002791 soaking Methods 0.000 claims description 5
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims description 5
- 229960001082 trimethoprim Drugs 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 3
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 3
- DBHODFSFBXJZNY-UHFFFAOYSA-N 2,4-dichlorobenzyl alcohol Chemical compound OCC1=CC=C(Cl)C=C1Cl DBHODFSFBXJZNY-UHFFFAOYSA-N 0.000 claims description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
- 239000001856 Ethyl cellulose Substances 0.000 claims description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 3
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 3
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 3
- 230000000249 desinfective effect Effects 0.000 claims description 3
- 229960004698 dichlorobenzyl alcohol Drugs 0.000 claims description 3
- 229920001249 ethyl cellulose Polymers 0.000 claims description 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 3
- 229940041616 menthol Drugs 0.000 claims description 3
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 claims description 2
- 229920000926 Galactomannan Polymers 0.000 claims description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- 239000004744 fabric Substances 0.000 abstract description 4
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- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 238000011065 in-situ storage Methods 0.000 description 3
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- ZSBXGIUJOOQZMP-UHFFFAOYSA-N Isomatrine Natural products C1CCC2CN3C(=O)CCCC3C3C2N1CCC3 ZSBXGIUJOOQZMP-UHFFFAOYSA-N 0.000 description 2
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- 230000008569 process Effects 0.000 description 2
- -1 quaternary ammonium salt compound Chemical class 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- GTQHJCOHNAFHRE-UHFFFAOYSA-N 1,10-dibromodecane Chemical compound BrCCCCCCCCCCBr GTQHJCOHNAFHRE-UHFFFAOYSA-N 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
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- 238000007792 addition Methods 0.000 description 1
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- 210000002421 cell wall Anatomy 0.000 description 1
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- 210000004400 mucous membrane Anatomy 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/04—Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
- A01N37/22—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Virology (AREA)
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Abstract
The invention discloses a long-acting antibacterial disinfectant and a preparation method thereof, wherein the disinfectant comprises the following components: 5-50 parts of disinfection active ingredient, 5-20 parts of film forming agent, 1-10 parts of sterilization synergist, 1-3 parts of pH regulator, 5-20 parts of penetrating agent and 100-200 parts of solvent. The disinfectant can form a layer of protective film on the surface of an object; the antibacterial and disinfectant agent not only has antibacterial and disinfectant functions, but also is convenient to apply, can be conveniently applied to the surfaces of fabrics, wood, metal, ceramics and plastics, and has antibacterial functions after being dried.
Description
Technical Field
The invention belongs to the technical field of disinfectants, relates to a disinfectant, and in particular relates to a long-acting antibacterial disinfectant and a preparation method thereof.
Background
A disinfectant refers to an agent that kills pathogenic microorganisms in a transmission medium, thereby rendering it harmless. At present, the disinfectants in the market are various in variety, and different disinfectants have different disinfection effects. In order to overcome the defect of single component, improve the disinfection effect, meet the requirements of ideal disinfectant such as broad spectrum, high efficiency, moderate cost, and the like as much as possible, most disinfectants in the market are compound disinfectants. Glutaraldehyde belongs to aldehyde high-efficiency disinfectants, but has a stimulating effect on mucous membranes and short action time; the decamethylene bromide belongs to a double-chain quaternary ammonium salt compound, has smaller antibacterial spectrum and limited action range, and can cooperate with glutaraldehyde to achieve the aim of quick disinfection after being compounded with glutaraldehyde.
The disinfection in a room is mainly represented by the following aspects:
(1) Various indoor pollution sources can be increased continuously along with time, the pollution degree of the indoor environment can be reduced only by indoor disinfection in time, and the pollution sources can be prevented from continuously emitting pollutant indoors, and the pollution sources are prevented from volatilizing in rooms or indoors and forming potential harm to the health of families.
(2) Various bacteria can be caused to grow due to the continuous increase of various pollution components, so that various indoor utensils, wall surfaces and washrooms are required to be disinfected and sterilized to avoid the random transmission of various harmful substances.
(3) The indoor environment is not disinfected for a long time, so that peculiar smell exists, and various bacteria exist in the air. When a person breathes deeply, speaks and sneezes, bacteria and germs can pass through the throat part of the person and then float in the air in the form of droplets and fall at all corners of the home, and particularly when infectious patients exist in the home, the germs carried in the droplets can infect families.
A sustainable antimicrobial disinfectant is thus an indispensable product for every household.
Disclosure of Invention
In order to solve the problems, the invention provides a long-acting antibacterial disinfectant and a preparation method thereof.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
the invention provides a long-acting antibacterial disinfectant, which comprises the following components in parts by weight: 5-50 parts of disinfection active ingredient, 5-20 parts of film forming agent, 1-10 parts of sterilization synergist, 1-3 parts of pH regulator, 5-20 parts of penetrating agent and 100-200 parts of solvent.
As a preferable scheme of the invention, the disinfectant comprises the following components in parts by weight: 10-40 parts of disinfection active ingredient, 12-20 parts of film forming agent, 1-5 parts of sterilization synergist, 1-3 parts of pH regulator, 5-15 parts of penetrating agent and 100-180 parts of solvent.
As a preferable scheme of the invention, the disinfectant comprises the following components in parts by weight: 15-30 parts of disinfection active ingredient, 12-15 parts of film forming agent, 3-5 parts of sterilization synergist, 1-3 parts of pH regulator, 5-10 parts of penetrating agent and 100-150 parts of solvent.
According to the invention, the disinfection active ingredient is protected on the surface of the object under the action of the film forming agent, so that the disinfection antibacterial effect is achieved, and the disinfection active ingredient has no phenomena of fading, corrosion and the like on the surface of the object, and is non-irritating, safe, stable and long-acting in antibacterial.
As a preferred embodiment of the present invention, the disinfecting active ingredient comprises one or more of 2, 4-dichlorobenzyl alcohol, 13 alpha-alkoxymatrine or chlorhexidine gluconate.
As a preferred embodiment of the present invention, the film forming agent includes at least one of galactomannan, galactosulfate or ethylcellulose.
As a preferred embodiment of the present invention, the osmotic agent includes one of azone, lauryl alcohol or menthol.
As a preferred embodiment of the present invention, the solvent is purified water.
As a preferable scheme of the invention, the preparation method of the sterilization synergistic agent comprises the following steps: 10-30 parts of trimethoprim, 20-50 parts of N-phenyl acrylamide, 30-40 parts of benzalkonium chloride, 3-6 parts of lysozyme and 5-8 parts of molybdenum oxide are added into a thickened glass reaction kettle, and are protected by nitrogen, and are irradiated by a light source with the wavelength of 525nm at the temperature of 155 ℃ for 4 hours; after the reaction is finished, flushing the polymer for 3 times by using nitrogen under the intermittent vacuumizing condition at 120 ℃ in the same reaction kettle, flushing and soaking the obtained reactant for ten minutes by 10 times of deionized water, repeating for 3 times, and finally, grinding the polymer obtained after vacuum drying for 5 hours at 95 ℃ into powder with the diameter of less than 0.3 mu m under the liquid nitrogen condition, and storing for later use.
In the invention, the substances are selected to cooperatively act, so that pathogenic bacteria with negative charges are adsorbed, bacterial cell wall mechanisms are destroyed, the content is leaked, and the actions of pathogenic bacteria oxidase, dehydrogenase and the like can be inhibited; lipid substances in pathogenic bacteria membrane can be removed and protein can be denatured; and the method can also interfere the mitosis process of pathogenic bacteria, inhibit the formation of a spindle body, influence the cytokinesis process of the pathogenic bacteria and realize the sterilization and synergy functions.
The invention also provides a preparation method of the long-acting antibacterial disinfectant, which comprises the following steps:
1) Adding the disinfection active ingredient, the film forming agent and the penetrating agent into a solvent according to the formula amount, and uniformly mixing to obtain a mixed solution A;
2) Preparing a sterilization synergistic agent;
3) Adding the sterilization synergistic agent obtained in the step 2) into the mixed solution A obtained in the step 1) to obtain a mixed solution B;
4) Adding a pH regulator into the mixed solution B obtained in the step 3), and uniformly mixing to obtain the long-acting antibacterial disinfectant.
Compared with the prior art, the invention has the following beneficial effects:
1) The disinfectant can form a layer of protective film on the surface of an object;
2) The disinfectant has the functions of antibiosis and disinfection, is convenient to apply, can be conveniently applied to the surfaces of fabrics, wood, metal, ceramics and plastics, and has the antibiosis function on the surfaces of materials after being dried.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The raw materials used in the present invention, if not specified, are commercially available.
Example 1
The embodiment provides a long-acting antibacterial disinfectant, which comprises the following components in parts by weight: 30 parts of disinfection active ingredient, 15 parts of film forming agent, 5 parts of sterilization synergistic agent, 3 parts of pH regulator, 10 parts of penetrating agent and 150 parts of solvent.
The disinfection active component is a mixture of 2, 4-dichlorobenzyl alcohol and 13 alpha-alkoxy matrine with the mass ratio of 1:1.
The film forming agent is galactose mannans.
The penetrating agent is azone.
The solvent is purified water.
The preparation method of the sterilization synergistic agent comprises the following steps: 20 parts of trimethoprim, 35 parts of N-phenyl acrylamide, 35 parts of benzalkonium chloride, 5 parts of lysozyme and 7 parts of molybdenum oxide are added into a thickened glass reaction kettle, and are protected by nitrogen, and are irradiated by a light source with the wavelength of 525nm at the temperature of 155 ℃ for 4 hours; after the reaction is finished, flushing the polymer for 3 times by using nitrogen under the intermittent vacuumizing condition at 120 ℃ in the same reaction kettle, flushing and soaking the obtained reactant for ten minutes by 10 times of deionized water, repeating for 3 times, and finally, grinding the polymer obtained after vacuum drying for 5 hours at 95 ℃ into powder with the diameter of less than 0.3 mu m under the liquid nitrogen condition, and storing for later use.
The preparation method of the long-acting antibacterial disinfectant comprises the following steps:
1) Adding the disinfection active ingredient, the film forming agent and the penetrating agent into a solvent according to the formula amount, and uniformly mixing to obtain a mixed solution A;
2) Preparing a sterilization synergistic agent;
3) Adding the sterilization synergistic agent obtained in the step 2) into the mixed solution A obtained in the step 1) to obtain a mixed solution B;
4) Adding a pH regulator into the mixed solution B obtained in the step 3), and uniformly mixing to obtain the long-acting antibacterial disinfectant.
Example 2
The embodiment provides a long-acting antibacterial disinfectant, which comprises the following components in parts by weight: 20 parts of disinfection active ingredient, 13 parts of film forming agent, 4 parts of sterilization synergistic agent, 2 parts of pH regulator, 8 parts of penetrating agent and 120 parts of solvent.
The disinfection active component is chlorhexidine gluconate.
The film forming agent is ethyl cellulose.
The penetrating agent is laurinol.
The solvent is purified water.
The preparation method of the sterilization synergistic agent comprises the following steps: 20 parts of trimethoprim, 50 parts of N-phenyl acrylamide, 40 parts of benzalkonium chloride, 6 parts of lysozyme and 8 parts of molybdenum oxide are added into a thickened glass reaction kettle, and are protected by nitrogen, and are irradiated by a light source with the wavelength of 525nm at the temperature of 155 ℃ for 4 hours; after the reaction is finished, flushing the polymer for 3 times by using nitrogen under the intermittent vacuumizing condition at 120 ℃ in the same reaction kettle, flushing and soaking the obtained reactant for ten minutes by 10 times of deionized water, repeating for 3 times, and finally, grinding the polymer obtained after vacuum drying for 5 hours at 95 ℃ into powder with the diameter of less than 0.3 mu m under the liquid nitrogen condition, and storing for later use.
The preparation method of the long-acting antibacterial disinfectant comprises the following steps:
1) Adding the disinfection active ingredient, the film forming agent and the penetrating agent into a solvent according to the formula amount, and uniformly mixing to obtain a mixed solution A;
2) Preparing a sterilization synergistic agent;
3) Adding the sterilization synergistic agent obtained in the step 2) into the mixed solution A obtained in the step 1) to obtain a mixed solution B;
4) Adding a pH regulator into the mixed solution B obtained in the step 3), and uniformly mixing to obtain the long-acting antibacterial disinfectant.
Example 3
The embodiment provides a long-acting antibacterial disinfectant, which comprises the following components in parts by weight: 15 parts of disinfection active ingredient, 12 parts of film forming agent, 3 parts of sterilization synergistic agent, 1 part of pH regulator, 5 parts of penetrating agent and 100 parts of solvent.
The disinfecting active ingredient is 13 alpha-alkoxyl matrine.
The film forming agent is sulfated galactan.
The penetrating agent is menthol.
The solvent is purified water.
The preparation method of the sterilization synergistic agent comprises the following steps: 10 parts of trimethoprim, 20 parts of N-phenyl acrylamide, 30 parts of benzalkonium chloride, 3 parts of lysozyme and 5 parts of molybdenum oxide are added into a thickened glass reaction kettle, and are protected by nitrogen, and are irradiated by a light source with the wavelength of 525nm at the temperature of 155 ℃ for 4 hours; after the reaction is finished, flushing the polymer for 3 times by using nitrogen under the intermittent vacuumizing condition at 120 ℃ in the same reaction kettle, flushing and soaking the obtained reactant for ten minutes by 10 times of deionized water, repeating for 3 times, and finally, grinding the polymer obtained after vacuum drying for 5 hours at 95 ℃ into powder with the diameter of less than 0.3 mu m under the liquid nitrogen condition, and storing for later use.
The preparation method of the long-acting antibacterial disinfectant comprises the following steps:
1) Adding the disinfection active ingredient, the film forming agent and the penetrating agent into a solvent according to the formula amount, and uniformly mixing to obtain a mixed solution A;
2) Preparing a sterilization synergistic agent;
3) Adding the sterilization synergistic agent obtained in the step 2) into the mixed solution A obtained in the step 1) to obtain a mixed solution B;
4) Adding a pH regulator into the mixed solution B obtained in the step 3), and uniformly mixing to obtain the long-acting antibacterial disinfectant.
Comparative example 1, identical to example 1, except that no bactericidal synergist was added.
The disinfectants prepared in examples 1-3 and the disinfectants prepared in comparative example 1 were tested according to the disinfection technical Specification (Ministry of health, 2002) 2.1.2.9 disinfectants for other surface disinfection simulation in-situ identification tests.
The test results are shown in tables 1 and 2:
TABLE 1 simulation of the results of in situ disinfection tests on fabric surfaces
Higher kill log values indicate better biocidal efficacy.
TABLE 2 simulation of the results of in situ disinfection tests on other object surfaces
As can be seen from tables 1 and 2, the disinfectant of the present invention has antibacterial and disinfectant functions, is convenient to apply, can be conveniently applied to the surfaces of fabrics, wood, metal, ceramics and plastics, and has antibacterial functions after being dried.
While the invention has been described with respect to preferred embodiments thereof, it will be understood by those skilled in the art that various modifications and additions may be made without departing from the scope of the invention. Equivalent embodiments of the present invention will be apparent to those skilled in the art having the benefit of the teachings disclosed herein, when considered in the light of the foregoing disclosure, and without departing from the spirit and scope of the invention; meanwhile, any equivalent changes, modifications and evolution of the above embodiments according to the essential technology of the present invention still fall within the scope of the technical solution of the present invention.
Claims (9)
1. The long-acting antibacterial disinfectant is characterized by comprising the following components in parts by weight: 5-50 parts of disinfection active ingredient, 5-20 parts of film forming agent, 1-10 parts of sterilization synergist, 1-3 parts of pH regulator, 5-20 parts of penetrating agent and 100-200 parts of solvent.
2. A long-acting antimicrobial disinfectant according to claim 1, characterized in that it comprises the following components in parts by weight: 10-40 parts of disinfection active ingredient, 12-20 parts of film forming agent, 1-5 parts of sterilization synergist, 1-3 parts of pH regulator, 5-15 parts of penetrating agent and 100-180 parts of solvent.
3. A long-acting antimicrobial disinfectant according to claim 1, characterized in that it comprises the following components in parts by weight: 15-30 parts of disinfection active ingredient, 12-15 parts of film forming agent, 3-5 parts of sterilization synergist, 1-3 parts of pH regulator, 5-10 parts of penetrating agent and 100-150 parts of solvent.
4. A long-acting antimicrobial disinfectant according to claim 1, 2 or 3, wherein the disinfecting active ingredient comprises one or more of 2, 4-dichlorobenzyl alcohol, 13 α -alkoxymatrine or chlorhexidine gluconate.
5. A long-acting antimicrobial disinfectant according to claim 1, 2 or 3, wherein the film forming agent comprises at least one of galactomannan, galactosulfate or ethylcellulose.
6. A long-acting antimicrobial disinfectant according to claim 1, 2 or 3, wherein the penetrating agent comprises one of azone, lauryl alcohol or menthol.
7. A long-acting antimicrobial disinfectant according to claim 1, 2 or 3, wherein the solvent is purified water.
8. A long-acting antimicrobial disinfectant according to claim 1, 2 or 3, characterized in that the method for preparing the antimicrobial synergist comprises the following steps: 10-30 parts of trimethoprim, 20-50 parts of N-phenyl acrylamide, 30-40 parts of benzalkonium chloride, 3-6 parts of lysozyme and 5-8 parts of molybdenum oxide are added into a thickened glass reaction kettle, and are protected by nitrogen, and are irradiated by a light source with the wavelength of 525nm at the temperature of 155 ℃ for 4 hours; after the reaction is finished, flushing the polymer for 3 times by using nitrogen under the intermittent vacuumizing condition at 120 ℃ in the same reaction kettle, flushing and soaking the obtained reactant for ten minutes by 10 times of deionized water, repeating for 3 times, and finally, grinding the polymer obtained after vacuum drying for 5 hours at 95 ℃ into powder with the diameter of less than 0.3 mu m under the liquid nitrogen condition, and storing for later use.
9. A method of preparing a long-acting antimicrobial disinfectant as claimed in any one of claims 1 to 8, comprising the steps of:
1) Adding the disinfection active ingredient, the film forming agent and the penetrating agent into a solvent according to the formula amount, and uniformly mixing to obtain a mixed solution A;
2) Preparing a sterilization synergistic agent;
3) Adding the sterilization synergistic agent obtained in the step 2) into the mixed solution A obtained in the step 1) to obtain a mixed solution B;
4) Adding a pH regulator into the mixed solution B obtained in the step 3), and uniformly mixing to obtain the long-acting antibacterial disinfectant.
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