CN116478293A - 治疗分子 - Google Patents

治疗分子 Download PDF

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Publication number
CN116478293A
CN116478293A CN202310315828.5A CN202310315828A CN116478293A CN 116478293 A CN116478293 A CN 116478293A CN 202310315828 A CN202310315828 A CN 202310315828A CN 116478293 A CN116478293 A CN 116478293A
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family
cdr3
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CN202310315828.5A
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Chinese (zh)
Inventor
布莱恩·麦吉尼斯
伊莎贝尔·奥苏奇
克里斯·罗桑特
麦克·罗曼诺斯
尼基·罗伊尔
托马斯·山道尔
洛林·汤普森
米歇尔·来特
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Crescendo Biologics Ltd
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Crescendo Biologics Ltd
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Priority claimed from GBGB1600559.7A external-priority patent/GB201600559D0/en
Application filed by Crescendo Biologics Ltd filed Critical Crescendo Biologics Ltd
Publication of CN116478293A publication Critical patent/CN116478293A/zh
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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CN202310315828.5A 2016-01-12 2017-01-12 治疗分子 Pending CN116478293A (zh)

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US10975161B2 (en) 2021-04-13
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