CN116421653A - Preparation process of ephedra, apricot kernel, gypsum and licorice oral liquid - Google Patents
Preparation process of ephedra, apricot kernel, gypsum and licorice oral liquid Download PDFInfo
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- CN116421653A CN116421653A CN202310588998.0A CN202310588998A CN116421653A CN 116421653 A CN116421653 A CN 116421653A CN 202310588998 A CN202310588998 A CN 202310588998A CN 116421653 A CN116421653 A CN 116421653A
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- oral liquid
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- ephedra
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- 239000007788 liquid Substances 0.000 title claims abstract description 92
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 title claims abstract description 44
- 229910052602 gypsum Inorganic materials 0.000 title claims abstract description 32
- 239000010440 gypsum Substances 0.000 title claims abstract description 32
- 241000218671 Ephedra Species 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 244000018633 Prunus armeniaca Species 0.000 title claims abstract description 24
- 235000009827 Prunus armeniaca Nutrition 0.000 title claims abstract description 24
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 title claims abstract description 17
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 title claims abstract description 17
- 229940010454 licorice Drugs 0.000 title claims abstract description 17
- 240000004670 Glycyrrhiza echinata Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract description 25
- 241000334154 Isatis tinctoria Species 0.000 claims abstract description 22
- 241000334160 Isatis Species 0.000 claims abstract description 16
- 240000004534 Scutellaria baicalensis Species 0.000 claims abstract description 16
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 15
- 230000001954 sterilising effect Effects 0.000 claims abstract description 10
- 239000003814 drug Substances 0.000 claims description 44
- 238000000605 extraction Methods 0.000 claims description 37
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 35
- 239000000463 material Substances 0.000 claims description 34
- 238000002791 soaking Methods 0.000 claims description 30
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 27
- 235000011477 liquorice Nutrition 0.000 claims description 27
- 102000004190 Enzymes Human genes 0.000 claims description 22
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- 238000001914 filtration Methods 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 244000144725 Amygdalus communis Species 0.000 claims description 14
- 239000000243 solution Substances 0.000 claims description 14
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- 235000011437 Amygdalus communis Nutrition 0.000 claims description 5
- 235000020224 almond Nutrition 0.000 claims description 5
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- 238000002156 mixing Methods 0.000 claims description 5
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- 230000004054 inflammatory process Effects 0.000 abstract description 7
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- CWVRJTMFETXNAD-BMNNCGMMSA-N (1s,3r,4s,5r)-3-[(e)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid Chemical compound O[C@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-BMNNCGMMSA-N 0.000 abstract description 5
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 abstract description 5
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- 241000588724 Escherichia coli Species 0.000 abstract description 5
- 244000167230 Lonicera japonica Species 0.000 abstract description 5
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- 206010048038 Wound infection Diseases 0.000 abstract description 5
- 239000003242 anti bacterial agent Substances 0.000 abstract description 5
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- 229930182470 glycoside Natural products 0.000 abstract description 5
- 150000002338 glycosides Chemical class 0.000 abstract description 5
- 241000411851 herbal medicine Species 0.000 abstract description 5
- 208000015181 infectious disease Diseases 0.000 abstract description 5
- 206010022000 influenza Diseases 0.000 abstract description 5
- KRZBCHWVBQOTNZ-DLDRDHNVSA-N isochlorogenic acid Natural products O[C@@H]1[C@H](C[C@@](O)(C[C@H]1OC(=O)C=Cc2ccc(O)c(O)c2)C(=O)O)OC(=O)C=Cc3ccc(O)c(O)c3 KRZBCHWVBQOTNZ-DLDRDHNVSA-N 0.000 abstract description 5
- 230000009291 secondary effect Effects 0.000 abstract description 5
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a preparation process of a ephedra, apricot kernel, gypsum and licorice oral liquid. In the invention, in the process of preparing the oral liquid, the baikal skullcap root, the isatis root and the dyers woad leaf are added in the raw materials, so that the prepared oral liquid can contain the antibacterial components such as the isochlorogenic acid, the lonicera japonica glycoside and the like in the body of poultry in the processes of diffusing the lung, relieving asthma and treating lung heat cough and asthma, has the strongest antibacterial effect on staphylococcus aureus, and has secondary effects on pseudomonas aeruginosa, escherichia coli and the like. Can treat influenza, enteritis, febrile infectious disease and wound infection of poultry, thereby playing a role in sterilizing and diminishing inflammation, playing a role in treating oral liquid, and simultaneously, as the Chinese herbal medicine raw materials are added, more antibiotics can not be remained in the poultry body, thereby improving the quality of the poultry.
Description
Technical Field
The invention belongs to the technical field of veterinary medicines, and in particular relates to a preparation process of a Maxing shigan oral liquid.
Background
The Chinese medicine oral liquid for animals is a Chinese medicine oral liquid which is recorded in a second volume of 'national standard for animal medicine local standard' and comprises main components of ephedra herb, almond, gypsum and liquorice. It has effects of clearing heat, dispersing lung qi, relieving asthma, and can be used for treating cough and asthma due to lung heat, and can be used for preventing and treating various respiratory diseases of chicken in clinic. The Ma xing shigan oral liquid is prepared from Shang Han Zhang Zhong Jing (Shang Han Lun Lung), has reasonable formula and obvious curative effect, and is suitable for various respiratory diseases caused by exogenous wind-heat and pathogenic factors attacking lung surface.
However, when animals such as common poultry use the oral liquid, the oral liquid can only play a role in relieving lung heat cough and asthma, and when the poultry has inflammation, the oral liquid cannot play a good role in diminishing inflammation.
Disclosure of Invention
The invention aims at: in order to solve the problems, a preparation process of the Maxing shigan oral liquid is provided.
The technical scheme adopted by the invention is as follows: a preparation process of a ephedra, apricot kernel, gypsum and licorice oral liquid comprises the following steps:
s1, firstly, weighing raw materials for preparing the ephedra, almond, bitter apricot seed, gypsum and dyers woad leaf, wherein the raw materials comprise 200-500 parts by weight of ephedra, 200-500 parts by weight of bitter apricot seed, 1000-2500 parts by weight of gypsum, 200-500 parts by weight of liquorice, 200-500 parts by weight of baical skullcap root, 200-500 parts by weight of radix isatidis and 200-500 parts by weight of dyers woad leaf;
s2, weighing herba Ephedrae, pulverizing herba Ephedrae, soaking in purified water, inoculating fermentation strain, fermenting for 8-12% for 15 hr at 35-40deg.C, fermenting, decocting herba Ephedrae under normal pressure at 85deg.C at a feed-liquid ratio of 1:10 for 3 times, extracting for 45min each time to obtain herba Ephedrae extractive solution, filtering, and concentrating to 300-500 mL;
s3, respectively carrying out normal-pressure decoction and extraction on the bitter almonds, gypsum and liquorice in the formula amount in the step S1, wherein the water addition amount is 4 times, the decoction temperature is 50 ℃ and the soaking time is 2.0 hours, respectively carrying out extraction on the mixed solution for two times, filtering the obtained solution, and respectively concentrating for later use;
s4, soaking and extracting the bactericidal traditional Chinese medicine herbs, and extracting the baikal skullcap root, the isatis root and the dyers woad leaf when heating is started after the soaking is finished; adding Scutellariae radix, radix Isatidis and folium Isatidis when the liquid medicine begins boiling, soaking and extracting;
s5, when the liquid medicine obtained in the steps S2-S4 is cooled, the pH is regulated to 4.5-5.0, 0.4-0.6 weight part of complex enzyme is added, the mixture is stirred uniformly, the enzymolysis is carried out for 0.8-1 h, and then the temperature is raised to 75-80 ℃ for enzyme inactivation treatment;
s6, decocting the liquid medicine obtained in the step S5 for 1.2 hours, and filtering to obtain filtrate; mixing the two decoctions, and centrifuging with a centrifuge to obtain supernatant;
s7, filtering the supernatant obtained in the step S6;
s8, concentrating the liquid medicine obtained in the step S7 under reduced pressure until the density is 1.07g/ml;
and S9, adding distilled water into the liquid medicine obtained in the step S8, uniformly stirring, filling, and sterilizing to obtain a finished product of the Maxingshi Gai oral liquid, and then ending the whole preparation process.
In a preferred embodiment, in the step S1, gypsum is crushed into small pieces having a block diameter of about not more than 1 cm.
In a preferred embodiment, in the step S1, the bitter apricot seeds are crushed into coarse particles with a particle size of 1/8-1/4 of the raw medicinal materials before being fed.
In a preferred embodiment, in the step S1, the licorice is a dried root and rhizome of licorice, or licorice, with a diameter of 0.6-3.5 cm and a length of 25-100 cm.
In a preferred embodiment, in the step S3, the 1 st extraction is performed for 2.0h, and the 2 nd extraction is performed by adding 2 times of water for 1.0h.
In a preferred embodiment, in the step S4, the baikal skullcap root, the isatis root and the dyers woad leaf are crushed into coarse particles with the particle size of 1/8-1/4 of the raw medicinal materials before being fed, and the temperature is controlled to be 100-105 ℃ during soaking and extraction.
In a preferred embodiment, in the step S5, the preparation of the mixed oral liquid is started when the liquid medicine obtained in the steps S2 to S4 is cooled to 45 to 50 ℃.
In a preferred embodiment, in the step S6, when the liquid medicine obtained in the step S5 is decocted, the temperature of the decoction is controlled to be 100-110 ℃.
In summary, due to the adoption of the technical scheme, the beneficial effects of the invention are as follows:
1. in the invention, in the process of preparing the oral liquid, the baikal skullcap root, the isatis root and the dyers woad leaf are added in the raw materials, so that the prepared oral liquid can contain the antibacterial components such as the isochlorogenic acid, the lonicera japonica glycoside and the like in the body of poultry in the processes of diffusing the lung, relieving asthma and treating lung heat cough and asthma, has the strongest antibacterial effect on staphylococcus aureus, and has secondary effects on pseudomonas aeruginosa, escherichia coli and the like. Can treat influenza, enteritis, febrile infectious disease and wound infection of poultry, thereby playing a role in sterilizing and diminishing inflammation, playing a role in treating oral liquid, and simultaneously, as the Chinese herbal medicine raw materials are added, more antibiotics can not be remained in the poultry body, thereby improving the quality of the poultry.
2. According to the invention, the ephedra medicinal material is subjected to crushing fermentation treatment before extraction, the granularity of the medicinal material is small, the plant cell wall is more easily damaged, the action area of enzyme and ephedra medicinal material substrate is larger, and the dissolution rate of the medicinal material effective components is higher; aiming at the medicinal characteristics of the Ma apricot shigan oral liquid, the method adds compound enzyme for auxiliary extraction, and the compound enzyme can quickly and effectively destroy structures such as plant cell wall cellulose and impurities such as pectin and the like at the optimal temperature and pH, so that the dissolution rate of medicinal material active ingredients is improved, and the method is simple and easy to operate, thereby increasing the medicinal material availability, saving resources and reducing the production cost.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described in the following in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Embodiment one:
a preparation process of a ephedra, apricot kernel, gypsum and licorice oral liquid comprises the following steps:
s1, firstly, weighing raw materials for preparing the ephedra, almond, gypsum 1000, liquorice, scutellaria baicalensis 200, isatis root 200 and dyers woad leaf 200 in parts by weight;
s2, weighing herba Ephedrae, pulverizing herba Ephedrae, soaking in purified water, inoculating fermentation strain, fermenting for 8-12% for 15 hr at 35-40deg.C, fermenting, decocting herba Ephedrae under normal pressure at 85deg.C at a feed-liquid ratio of 1:10 for 3 times, extracting for 45min each time to obtain herba Ephedrae extractive solution, filtering, and concentrating to 300-500 mL;
s3, respectively carrying out normal-pressure decoction and extraction on the bitter almonds, gypsum and liquorice in the formula amount in the step S1, wherein the water addition amount is 4 times, the decoction temperature is 50 ℃ and the soaking time is 2.0 hours, respectively carrying out extraction on the mixed solution for two times, filtering the obtained solution, and respectively concentrating for later use;
s4, soaking and extracting the bactericidal traditional Chinese medicine herbs, and extracting the baikal skullcap root, the isatis root and the dyers woad leaf when heating is started after the soaking is finished; adding Scutellariae radix, radix Isatidis and folium Isatidis when the liquid medicine begins boiling, soaking and extracting;
s5, when the liquid medicine obtained in the steps S2-S4 is cooled, the pH is regulated to 4.5-5.0, 0.4-0.6 weight part of complex enzyme is added, the mixture is stirred uniformly, the enzymolysis is carried out for 0.8-1 h, and then the temperature is raised to 75-80 ℃ for enzyme inactivation treatment;
s6, decocting the liquid medicine obtained in the step S5 for 1.2 hours, and filtering to obtain filtrate; mixing the two decoctions, and centrifuging with a centrifuge to obtain supernatant;
s7, filtering the supernatant obtained in the step S6;
s8, concentrating the liquid medicine obtained in the step S7 under reduced pressure until the density is 1.07g/ml;
and S9, adding distilled water into the liquid medicine obtained in the step S8, uniformly stirring, filling, and sterilizing to obtain a finished product of the Maxingshi Gai oral liquid, and then ending the whole preparation process.
In the step S1, gypsum is crushed into small pieces having a block diameter of about 1cm or less.
In the step S1, the bitter almonds are crushed into coarse grains with the grain size of 1/8-1/4 of that of the raw medicinal materials before being fed.
In the step S1, the liquorice is dry roots and rhizomes of liquorice, liquorice with expanding fruits or liquorice with the diameter of 0.6-3.5 cm and the length of 25-100 cm.
In the step S3, the 1 st extraction is carried out for 2.0h, the 2 nd extraction is carried out by adding 2 times of water, and the extraction is carried out for 1.0h.
In the step S4, the baikal skullcap root, the isatis root and the dyers woad leaf are crushed into coarse grains with the grain size of 1/8-1/4 of the raw medicinal materials before being fed, and the temperature is controlled to be 100-105 ℃ during soaking and extraction.
In the step S5, the preparation of the mixed oral liquid is started when the liquid medicine obtained in the steps S2 to S4 is cooled to 45 to 50 ℃.
In the step S6, when the liquid medicine obtained in the step S5 is decocted, the temperature of the decoction is controlled to be 100-110 DEG C
In the invention, in the process of preparing the oral liquid, the baikal skullcap root, the isatis root and the dyers woad leaf are added in the raw materials, so that the prepared oral liquid can contain the antibacterial components such as the isochlorogenic acid, the lonicera japonica glycoside and the like in the body of poultry in the processes of diffusing the lung, relieving asthma and treating lung heat cough and asthma, has the strongest antibacterial effect on staphylococcus aureus, and has secondary effects on pseudomonas aeruginosa, escherichia coli and the like. Can treat influenza, enteritis, febrile infectious disease and wound infection of poultry, thereby playing a role in sterilizing and diminishing inflammation, playing a role in treating oral liquid, and simultaneously, as the Chinese herbal medicine raw materials are added, more antibiotics can not be remained in the poultry body, thereby improving the quality of the poultry.
According to the invention, the ephedra medicinal material is subjected to crushing fermentation treatment before extraction, the granularity of the medicinal material is small, the plant cell wall is more easily damaged, the action area of enzyme and ephedra medicinal material substrate is larger, and the dissolution rate of the medicinal material effective components is higher; aiming at the medicinal characteristics of the Ma apricot shigan oral liquid, the method adds compound enzyme for auxiliary extraction, and the compound enzyme can quickly and effectively destroy structures such as plant cell wall cellulose and impurities such as pectin and the like at the optimal temperature and pH, so that the dissolution rate of medicinal material active ingredients is improved, and the method is simple and easy to operate, thereby increasing the medicinal material availability, saving resources and reducing the production cost.
Embodiment two:
a preparation process of a ephedra, apricot kernel, gypsum and licorice oral liquid comprises the following steps:
s1, firstly, weighing 500 parts by weight of ephedra herb, 500 parts by weight of bitter apricot seed, 2500 parts by weight of gypsum, 500 parts by weight of liquorice, 500 parts by weight of baical skullcap root, 500 parts by weight of radix isatidis and 200-500 parts by weight of dyers woad leaf;
s2, weighing herba Ephedrae, pulverizing herba Ephedrae, soaking in purified water, inoculating fermentation strain, fermenting for 8-12% for 15 hr at 35-40deg.C, fermenting, decocting herba Ephedrae under normal pressure at 85deg.C at a feed-liquid ratio of 1:10 for 3 times, extracting for 45min each time to obtain herba Ephedrae extractive solution, filtering, and concentrating to 300-500 mL;
s3, respectively carrying out normal-pressure decoction and extraction on the bitter almonds, gypsum and liquorice in the formula amount in the step S1, wherein the water addition amount is 4 times, the decoction temperature is 50 ℃ and the soaking time is 2.0 hours, respectively carrying out extraction on the mixed solution for two times, filtering the obtained solution, and respectively concentrating for later use;
s4, soaking and extracting the bactericidal traditional Chinese medicine herbs, and extracting the baikal skullcap root, the isatis root and the dyers woad leaf when heating is started after the soaking is finished; adding Scutellariae radix, radix Isatidis and folium Isatidis when the liquid medicine begins boiling, soaking and extracting;
s5, when the liquid medicine obtained in the steps S2-S4 is cooled, the pH is regulated to 4.5-5.0, 0.4-0.6 weight part of complex enzyme is added, the mixture is stirred uniformly, the enzymolysis is carried out for 0.8-1 h, and then the temperature is raised to 75-80 ℃ for enzyme inactivation treatment;
s6, decocting the liquid medicine obtained in the step S5 for 1.2 hours, and filtering to obtain filtrate; mixing the two decoctions, and centrifuging with a centrifuge to obtain supernatant;
s7, filtering the supernatant obtained in the step S6;
s8, concentrating the liquid medicine obtained in the step S7 under reduced pressure until the density is 1.07g/ml;
and S9, adding distilled water into the liquid medicine obtained in the step S8, uniformly stirring, filling, and sterilizing to obtain a finished product of the Maxingshi Gai oral liquid, and then ending the whole preparation process.
In the step S1, gypsum is crushed into small pieces having a block diameter of about 1cm or less.
In the step S1, the bitter almonds are crushed into coarse grains with the grain size of 1/8-1/4 of that of the raw medicinal materials before being fed.
In the step S1, the liquorice is dry roots and rhizomes of liquorice, liquorice with expanding fruits or liquorice with the diameter of 0.6-3.5 cm and the length of 25-100 cm.
In the step S3, the 1 st extraction is carried out for 2.0h, the 2 nd extraction is carried out by adding 2 times of water, and the extraction is carried out for 1.0h.
In the step S4, the baikal skullcap root, the isatis root and the dyers woad leaf are crushed into coarse grains with the grain size of 1/8-1/4 of the raw medicinal materials before being fed, and the temperature is controlled to be 100-105 ℃ during soaking and extraction.
In the step S5, the preparation of the mixed oral liquid is started when the liquid medicine obtained in the steps S2 to S4 is cooled to 45 to 50 ℃.
In the step S6, when the liquid medicine obtained in the step S5 is decocted, the temperature of the decoction is controlled to be 100-110 DEG C
In the invention, in the process of preparing the oral liquid, the baikal skullcap root, the isatis root and the dyers woad leaf are added in the raw materials, so that the prepared oral liquid can contain the antibacterial components such as the isochlorogenic acid, the lonicera japonica glycoside and the like in the body of poultry in the processes of diffusing the lung, relieving asthma and treating lung heat cough and asthma, has the strongest antibacterial effect on staphylococcus aureus, and has secondary effects on pseudomonas aeruginosa, escherichia coli and the like. Can treat influenza, enteritis, febrile infectious disease and wound infection of poultry, thereby playing a role in sterilizing and diminishing inflammation, playing a role in treating oral liquid, and simultaneously, as the Chinese herbal medicine raw materials are added, more antibiotics can not be remained in the poultry body, thereby improving the quality of the poultry.
According to the invention, the ephedra medicinal material is subjected to crushing fermentation treatment before extraction, the granularity of the medicinal material is small, the plant cell wall is more easily damaged, the action area of enzyme and ephedra medicinal material substrate is larger, and the dissolution rate of the medicinal material effective components is higher; aiming at the medicinal characteristics of the Ma apricot shigan oral liquid, the method adds compound enzyme for auxiliary extraction, and the compound enzyme can quickly and effectively destroy structures such as plant cell wall cellulose and impurities such as pectin and the like at the optimal temperature and pH, so that the dissolution rate of medicinal material active ingredients is improved, and the method is simple and easy to operate, thereby increasing the medicinal material availability, saving resources and reducing the production cost.
Embodiment III:
a preparation process of a ephedra, apricot kernel, gypsum and licorice oral liquid comprises the following steps:
s1, firstly, weighing raw materials for preparing the ephedra, almond, gypsum 1500 parts, liquorice 400 parts, radix scutellariae 400 parts, radix isatidis 450 parts and dyers woad leaf 400 parts;
s2, weighing herba Ephedrae, pulverizing herba Ephedrae, soaking in purified water, inoculating fermentation strain, fermenting for 8-12% for 15 hr at 35-40deg.C, fermenting, decocting herba Ephedrae under normal pressure at 85deg.C at a feed-liquid ratio of 1:10 for 3 times, extracting for 45min each time to obtain herba Ephedrae extractive solution, filtering, and concentrating to 300-500 mL;
s3, respectively carrying out normal-pressure decoction and extraction on the bitter almonds, gypsum and liquorice in the formula amount in the step S1, wherein the water addition amount is 4 times, the decoction temperature is 50 ℃ and the soaking time is 2.0 hours, respectively carrying out extraction on the mixed solution for two times, filtering the obtained solution, and respectively concentrating for later use;
s4, soaking and extracting the bactericidal traditional Chinese medicine herbs, and extracting the baikal skullcap root, the isatis root and the dyers woad leaf when heating is started after the soaking is finished; adding Scutellariae radix, radix Isatidis and folium Isatidis when the liquid medicine begins boiling, soaking and extracting;
s5, when the liquid medicine obtained in the steps S2-S4 is cooled, the pH is regulated to 4.5-5.0, 0.4-0.6 weight part of complex enzyme is added, the mixture is stirred uniformly, the enzymolysis is carried out for 0.8-1 h, and then the temperature is raised to 75-80 ℃ for enzyme inactivation treatment;
s6, decocting the liquid medicine obtained in the step S5 for 1.2 hours, and filtering to obtain filtrate; mixing the two decoctions, and centrifuging with a centrifuge to obtain supernatant;
s7, filtering the supernatant obtained in the step S6;
s8, concentrating the liquid medicine obtained in the step S7 under reduced pressure until the density is 1.07g/ml;
and S9, adding distilled water into the liquid medicine obtained in the step S8, uniformly stirring, filling, and sterilizing to obtain a finished product of the Maxingshi Gai oral liquid, and then ending the whole preparation process.
In the step S1, gypsum is crushed into small pieces having a block diameter of about 1cm or less.
In the step S1, the bitter almonds are crushed into coarse grains with the grain size of 1/8-1/4 of that of the raw medicinal materials before being fed.
In the step S1, the liquorice is dry roots and rhizomes of liquorice, liquorice with expanding fruits or liquorice with the diameter of 0.6-3.5 cm and the length of 25-100 cm.
In the step S3, the 1 st extraction is carried out for 2.0h, the 2 nd extraction is carried out by adding 2 times of water, and the extraction is carried out for 1.0h.
In the step S4, the baikal skullcap root, the isatis root and the dyers woad leaf are crushed into coarse grains with the grain size of 1/8-1/4 of the raw medicinal materials before being fed, and the temperature is controlled to be 100-105 ℃ during soaking and extraction.
In the step S5, the preparation of the mixed oral liquid is started when the liquid medicine obtained in the steps S2 to S4 is cooled to 45 to 50 ℃.
In the step S6, when the liquid medicine obtained in the step S5 is decocted, the temperature of the decoction is controlled to be 100-110 DEG C
In the invention, in the process of preparing the oral liquid, the baikal skullcap root, the isatis root and the dyers woad leaf are added in the raw materials, so that the prepared oral liquid can contain the antibacterial components such as the isochlorogenic acid, the lonicera japonica glycoside and the like in the body of poultry in the processes of diffusing the lung, relieving asthma and treating lung heat cough and asthma, has the strongest antibacterial effect on staphylococcus aureus, and has secondary effects on pseudomonas aeruginosa, escherichia coli and the like. Can treat influenza, enteritis, febrile infectious disease and wound infection of poultry, thereby playing a role in sterilizing and diminishing inflammation, playing a role in treating oral liquid, and simultaneously, as the Chinese herbal medicine raw materials are added, more antibiotics can not be remained in the poultry body, thereby improving the quality of the poultry.
According to the invention, the ephedra medicinal material is subjected to crushing fermentation treatment before extraction, the granularity of the medicinal material is small, the plant cell wall is more easily damaged, the action area of enzyme and ephedra medicinal material substrate is larger, and the dissolution rate of the medicinal material effective components is higher; aiming at the medicinal characteristics of the Ma apricot shigan oral liquid, the method adds compound enzyme for auxiliary extraction, and the compound enzyme can quickly and effectively destroy structures such as plant cell wall cellulose and impurities such as pectin and the like at the optimal temperature and pH, so that the dissolution rate of medicinal material active ingredients is improved, and the method is simple and easy to operate, thereby increasing the medicinal material availability, saving resources and reducing the production cost.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
The above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (8)
1. A preparation process of a Ma xing shigan oral liquid is characterized in that: the method comprises the following steps:
s1, firstly, weighing raw materials for preparing the ephedra, almond, bitter apricot seed, gypsum and dyers woad leaf, wherein the raw materials comprise 200-500 parts by weight of ephedra, 200-500 parts by weight of bitter apricot seed, 1000-2500 parts by weight of gypsum, 200-500 parts by weight of liquorice, 200-500 parts by weight of baical skullcap root, 200-500 parts by weight of radix isatidis and 200-500 parts by weight of dyers woad leaf;
s2, weighing herba Ephedrae, pulverizing herba Ephedrae, soaking in purified water, inoculating fermentation strain, fermenting for 8-12% for 15 hr at 35-40deg.C, fermenting, decocting herba Ephedrae under normal pressure at 85deg.C at a feed-liquid ratio of 1:10 for 3 times, extracting for 45min each time to obtain herba Ephedrae extractive solution, filtering, and concentrating to 300-500 mL;
s3, respectively carrying out normal-pressure decoction and extraction on the bitter almonds, gypsum and liquorice in the formula amount in the step S1, wherein the water addition amount is 4 times, the decoction temperature is 50 ℃ and the soaking time is 2.0 hours, respectively carrying out extraction on the mixed solution for two times, filtering the obtained solution, and respectively concentrating for later use;
s4, soaking and extracting the bactericidal traditional Chinese medicine herbs, and extracting the baikal skullcap root, the isatis root and the dyers woad leaf when heating is started after the soaking is finished; adding Scutellariae radix, radix Isatidis and folium Isatidis when the liquid medicine begins boiling, soaking and extracting;
s5, when the liquid medicine obtained in the steps S2-S4 is cooled, the pH is regulated to 4.5-5.0, 0.4-0.6 weight part of complex enzyme is added, the mixture is stirred uniformly, the enzymolysis is carried out for 0.8-1 h, and then the temperature is raised to 75-80 ℃ for enzyme inactivation treatment;
s6, decocting the liquid medicine obtained in the step S5 for 1.2 hours, and filtering to obtain filtrate; mixing the two decoctions, and centrifuging with a centrifuge to obtain supernatant;
s7, filtering the supernatant obtained in the step S6;
s8, concentrating the liquid medicine obtained in the step S7 under reduced pressure until the density is 1.07g/ml;
and S9, adding distilled water into the liquid medicine obtained in the step S8, uniformly stirring, filling, and sterilizing to obtain a finished product of the Maxingshi Gai oral liquid, and then ending the whole preparation process.
2. The preparation process of the ephedra, apricot kernel, gypsum and licorice oral liquid according to claim 1, which is characterized in that: in the step S1, gypsum is crushed into small pieces having a block diameter of about 1cm or less.
3. The preparation process of the ephedra, apricot kernel, gypsum and licorice oral liquid according to claim 1, which is characterized in that: in the step S1, the bitter almonds are crushed into coarse grains with the grain size of 1/8-1/4 of that of the raw medicinal materials before being fed.
4. The preparation process of the ephedra, apricot kernel, gypsum and licorice oral liquid according to claim 1, which is characterized in that: in the step S1, the liquorice is dry roots and rhizomes of liquorice, liquorice with expanding fruits or liquorice with the diameter of 0.6-3.5 cm and the length of 25-100 cm.
5. The preparation process of the ephedra, apricot kernel, gypsum and licorice oral liquid according to claim 1, which is characterized in that: in the step S3, the 1 st extraction is carried out for 2.0h, the 2 nd extraction is carried out by adding 2 times of water, and the extraction is carried out for 1.0h.
6. The preparation process of the ephedra, apricot kernel, gypsum and licorice oral liquid according to claim 1, which is characterized in that: in the step S4, the baikal skullcap root, the isatis root and the dyers woad leaf are crushed into coarse grains with the grain size of 1/8-1/4 of the raw medicinal materials before being fed, and the temperature is controlled to be 100-105 ℃ during soaking and extraction.
7. The preparation process of the ephedra, apricot kernel, gypsum and licorice oral liquid according to claim 1, which is characterized in that: in the step S5, the preparation of the mixed oral liquid is started when the liquid medicine obtained in the steps S2 to S4 is cooled to 45 to 50 ℃.
8. The preparation process of the ephedra, apricot kernel, gypsum and licorice oral liquid according to claim 1, which is characterized in that: in the step S6, when the liquid medicine obtained in the step S5 is decocted, the temperature of the decoction is controlled to be 100-110 ℃.
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| CN110548075A (en) * | 2019-10-18 | 2019-12-10 | 河南黑马动物药业有限公司 | Preparation method of veterinary ephedra, apricot kernel, gypsum and licorice oral liquid |
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| CN1895398A (en) * | 2006-06-15 | 2007-01-17 | 贵州太和制药有限公司 | Preparation of infantie heating-clearing and antitussive effervescent particles |
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