CN116392538A - Novel medical gynecological gel - Google Patents

Novel medical gynecological gel Download PDF

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Publication number
CN116392538A
CN116392538A CN202310575622.6A CN202310575622A CN116392538A CN 116392538 A CN116392538 A CN 116392538A CN 202310575622 A CN202310575622 A CN 202310575622A CN 116392538 A CN116392538 A CN 116392538A
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parts
extract
motherwort
cordate houttuynia
nano silver
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曾莉莉
汪铭
付玉平
廖清红
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Jiangxi Jinsikang Pharmaceutical Co ltd
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Jiangxi Jinsikang Pharmaceutical Co ltd
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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Abstract

The invention discloses a novel medical gynecological gel, which relates to the field of gynecological gels and comprises the following components in parts by weight: 2 to 20 parts of licorice root extract, 3 to 18 parts of kuh-seng extract, 2 to 19 parts of herba patriniae extract, 3 to 8 parts of winter ash, 10 to 15 parts of motherwort extract, 15 to 35 parts of cordate houttuynia extract, 2 to 6 parts of wormwood essential oil, 80 parts of edible gelatin and 2 to 13 parts of nano silver antibacterial gel. The mode of using the nano silver antibacterial gel can have strong inhibition and killing effects on virus strains, does not damage human and environment, enables active ingredients of the medicine to be fully attached to the skin surface of a patient, and solves the problems that the antibacterial medicine composed of the traditional Chinese medicine composition as the active ingredients is not definite in curative effect and is slow in effect.

Description

Novel medical gynecological gel
Technical Field
The invention relates to the field of gynecological gel, in particular to novel medical gynecological gel.
Background
Female genital organs are naturally warm and moist, and can easily grow microorganisms. Normally, the self-heating structure and chemical environment of the human body can play a role in protection, so that lesions are avoided. On one hand, the labia majora on both sides of the vulva are naturally folded to cover the vaginal orifice, so that exogenous microorganisms are difficult to enter; in the vagina, the anterior and posterior walls of the vagina are clung due to the action of the muscles of the pelvic floor, and the vaginal orifice is closed, so that the external pollution can be prevented to a certain extent. On the other hand, under the influence of estrogen, the vaginal epithelial cells are continuously metabolized and proliferated and thickened, so that the resistance to pathogens is increased; meanwhile, glycogen rich in vaginal epithelial cells can be decomposed into lactic acid under the action of vaginal bacillus so as to maintain the normal acidic environment of the vagina, and pathogens suitable for propagation in weak alkaline environment are inhibited. Thus, healthy women have some bacteria present in the vagina but generally do not cause inflammation.
Normally, the vagina is dominated by colpitis, and a small amount of anaerobic bacteria, mycoplasma and candida are also included, and the flora forms a certain ecological balance. However, when the immunity of the human body is low, endocrine hormones are changed, or external factors such as tissue damage and intercourse destroy the ecological balance of the vagina, the vaginal infection may be caused by these resident flora, and pathogenic microorganisms from the outside may be introduced while the bacteria are still deficient. In addition, the female vagina gradually relaxes with age, labor, etc., and the risk of invasion of exogenous microorganisms increases.
When such gynecological diseases occur, it is usually combined with drug therapy, for example, oral antibiotics, external antibacterial drugs, etc., in addition to relying on autoimmune systems. Because the infection is different from in-vivo organ infection, the disease position is on the body surface, so the curative effect of the externally applied medicine is more direct. The vaginal antibacterial drugs in the prior art can be divided into two main categories, wherein one category is antibacterial drugs which take antibiotics as active ingredients, the drugs have quicker onset of action, but are easy to have tolerance, and have no selectivity on the inhibition of microorganisms, so that the vaginal flora needs to be reconstructed for a long time after stopping the drugs, and the secondary infection is easy to occur in the process; another type of antibacterial medicine takes the traditional Chinese medicine composition as an active ingredient, and has the advantages of less skin irritation and no microbial tolerance phenomenon, but has the defects of partial medicine with uncertain curative effect and slower onset of action.
Therefore, it is necessary to propose a new medical gynecological gel to solve the above problems.
Disclosure of Invention
The invention aims to provide a novel medical gynecological gel, which aims to solve the problems that the antibacterial medicine consisting of a traditional Chinese medicine composition as an active ingredient is not definite in curative effect and is slow in onset of action.
In order to achieve the above purpose, the present invention provides the following technical solutions: a novel medical gynecological gel comprises the following components in parts by weight: 2 to 20 parts of licorice root extract, 3 to 18 parts of kuh-seng extract, 2 to 19 parts of herba patriniae extract, 3 to 8 parts of winter ash, 10 to 15 parts of motherwort extract, 15 to 35 parts of cordate houttuynia extract, 2 to 6 parts of wormwood essential oil, 80 parts of edible gelatin and 2 to 13 parts of nano silver antibacterial gel.
Preferably, the synthesis steps of the nano silver antibacterial gel comprise:
s1: weighing a certain amount of silver nitrate, adding water for dissolution, and placing into a brown volumetric flask for standby;
s2: weighing a certain amount of water-soluble chitosan, adding water for dissolution to prepare a solution with a certain concentration, filtering, and placing in a closed bottle for standby;
s3: respectively taking glucose and chitosan aqueous solution according to the mass ratio of the silver nitrate, uniformly mixing, adding water, then adding the silver nitrate solution into the solution under stirring to ensure that the concentration of silver is 900-1100ppm, placing the mixed solution into an ultrasonic oscillator, carrying out ultrasonic oscillation for 5-10Min under the condition of pressurization and the temperature range of 30-35 ℃, reducing Ag+ under the combined action of ultrasonic waves, chitosan and glucose to generate Ag atoms, and uniformly dispersing the Ag atoms in the chitosan colloid solution;
s4: the molar ratio of potassium borohydride to silver nitrate is as follows: 1.5 to 3, the mass ratio of polyvinylpyrrolidone to silver nitrate is 1:0.8 to 1.5, and carrying out ultrasonic oscillation for 15 to 40 minutes to prepare nano silver colloid;
s5: weighing 500ml of distilled water, putting into a 1000ml beaker, opening stirring, weighing 5g of carbomer resin, slowly adding into a vortex of distilled water under rapid stirring to completely dissolve and disperse uniformly, adding 25 g of glycerol, stirring uniformly, neutralizing with triethanolamine to pH of about 6, adding nano silver sol to make the nano silver content be 100ppm, stirring uniformly, adding water to 500ml, and stirring uniformly to obtain the nano silver antibacterial gel.
Preferably, the pressurizing condition in S3 is 0.1-1Mpa.
Preferably, the medical gynecological gel comprises the following preparation steps:
step one, preparing a material A, namely mixing licorice root extract, radix sophorae flavescentis extract, herba patriniae extract, winter ash, motherwort extract and cordate houttuynia extract, and fully stirring to form the material A;
step two, preparing a material B, mixing the nano silver antibacterial gel and the edible gelatin, fully stirring to form the material B, and preparing the wormwood essential oil for later use;
and step three, mixing the material A and the material B, adding the mugwort essential oil uniformly, and stirring uniformly to obtain the medical gynecological gel.
Preferably, the steps of extracting the licorice root extract, the lightyellow sophora root extract, the patrinia herb extract, the motherwort herb extract and the cordate houttuynia extract are as follows:
a1: picking and cleaning, namely cleaning the picked licorice root, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia by clean water and draining for later use;
a2: c, freezing, namely weighing a certain amount of licorice roots, kuh-seng, herba patriniae, motherwort and cordate houttuynia obtained in the step A1, freezing for 1-3 hours, and freezing into a state of easy brittle fracture;
a3: crushing the frozen licorice roots, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia by using a crusher, keeping the crushing environment at low temperature, and crushing to form Wen Gancao roots, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia residues;
a4: distilling, namely transferring the low Wen Gancao root, kuh-seng, patrinia herb, motherwort herb and cordate houttuynia slag into a distillation kettle, distilling at 50-200 ℃ for 1.5-4 hours, and cooling to obtain an oil-water mixture;
a5: separating oil and water, separating oil-water mixture in a standing separator, collecting the upper layer of Glycyrrhrizae radix, radix Sophorae Flavescentis, herba Patriniae, herba Leonuri, and herba Houttuyniae extract, and the lower layer of water containing small amount of Glycyrrhrizae radix, radix Sophorae Flavescentis, herba Patriniae, herba Leonuri, and herba Houttuyniae extract, and distilling again in a distilling kettle.
Preferably, the composition comprises the following components in parts by weight: 2 parts of licorice root extract, 3 parts of kuh-seng extract, 2 parts of herba patriniae extract, 3 parts of winter ash, 10 parts of motherwort extract, 15 parts of cordate houttuynia extract, 2 parts of wormwood essential oil, 80 parts of edible gelatin and 2 parts of nano silver antibacterial gel.
Preferably, the composition comprises the following components in parts by weight: 5 parts of licorice root extract, 5 parts of radix sophorae flavescentis extract, 10 parts of herba patriniae extract, 5 parts of winter ash, 11 parts of motherwort extract, 20 parts of cordate houttuynia extract, 4 parts of wormwood essential oil, 80 parts of edible gelatin and 5 parts of nano silver antibacterial gel.
Preferably, the composition comprises the following components in parts by weight: 18 parts of licorice root extract, 15 parts of kuh-seng extract, 17 parts of herba patriniae extract, 7 parts of winter ash, 14 parts of motherwort extract, 30 parts of cordate houttuynia extract, 5 parts of wormwood essential oil, 80 parts of edible gelatin and 10 parts of nano silver antibacterial gel.
Preferably, the composition comprises the following components in parts by weight: 20 parts of licorice root extract, 18 parts of radix sophorae flavescentis extract, 19 parts of herba patriniae extract, 8 parts of winter ash, 15 parts of motherwort extract, 35 parts of cordate houttuynia extract, 6 parts of wormwood essential oil, 80 parts of edible gelatin and 13 parts of nano silver antibacterial gel.
The invention has the technical effects and advantages that:
1. the licorice root extract has the functions of invigorating spleen and replenishing qi, clearing heat and detoxicating, eliminating phlegm and relieving cough, relieving spasm and pain, harmonizing various medicines, and is used for treating weakness of spleen and stomach, lassitude and hypodynamia, palpitation and shortness of breath, cough with excessive phlegm, contracture pain of epigastrium, abdomen and limbs, carbuncle, swelling and sore toxin, and relieving medicine toxicity and intensity; the radix Sophorae Flavescentis extract can be used for treating heart and abdomen qi, abdominal mass, jaundice, excessive dribbling, water-repellent, carbuncle, and lacrimation. Modern pharmacological research proves that kuh-seng contains matrine and has inhibition effect on various dermatophytes and tubercle bacillus; herba Patriniae extract has effects of clearing heat and detoxicating, eliminating phlegm and expelling pus, and is commonly used for treating acute appendicitis, pulmonary abscess, dysentery, puerperal abdominal pain due to blood stasis, carbuncle and furuncle; the winter ash is used for dispelling cold, detumescence, eliminating symptoms, removing accumulation, treating the bone joint disease, and eroding the carbuncles and the malignant meats; the herba Leonuri extract has effects of promoting blood circulation, removing blood stasis, regulating menstruation, and eliminating water, and can be used for treating menoxenia, dystocia, and retention of placenta, puerperal blood stasis abdominal pain, metrorrhagia, hematuria, blood diarrhea, pain, swelling, and pyocutaneous disease; the cordate houttuynia extract has the effects of clearing heat and detoxicating, detumescence and sore treatment, promoting urination and removing dampness, clearing heat and stopping dysentery, invigorating stomach and promoting digestion, and has the effects of resisting bacteria, resisting viruses, improving organism immunity, promoting urination and the like when being used for treating lung carbuncle, sore and ulcer pyogenic infections, hemorrhoids and hematochezia, spleen and stomach heat accumulation and the like caused by excessive heat and disease; the wormwood essential oil contains the effective components of wormwood, and the wormwood can be used as a medicine, has the effects of warming channels, removing dampness, dispelling cold, stopping bleeding, diminishing inflammation, relieving asthma, relieving cough, preventing miscarriage, resisting allergy and the like, is one of common gynecological medicines, and is particularly good for treating deficiency-cold gynecological diseases;
2. the edible gelatin has certain adhesiveness, so that the licorice root extract, the kuh-seng extract, the herba patriniae extract, the winter ash, the motherwort extract, the cordate houttuynia extract and the nano-silver antibacterial gel can be effectively adhered to the skin surface of a patient, and the edible gelatin has a continuous medicinal effect;
3. according to the invention, the wormwood essential oil is used for treating the gynecological diseases caused by deficiency-cold, and can be mixed with the licorice root extract, the radix sophorae flavescentis extract, the herba patriniae extract, the winter ash, the motherwort extract, the cordate houttuynia extract and the nano-silver antibacterial gel to increase the fluidity and adhesiveness of the gynecological gel to a certain extent, so that the gynecological gel acts on more skin surfaces;
4. the mode of using the nano silver antibacterial gel can have strong inhibition and killing effects on virus strains, does not damage people and the environment, combines the nano silver antibacterial gel with licorice root extract, kuh-seng extract, herba patriniae extract, winter ash, motherwort extract and cordate houttuynia extract, so that the active ingredients of the medicament are fully attached to the skin surface of a patient, and the problems that the antibacterial medicament consisting of the traditional Chinese medicine composition as the active ingredients is not definite in curative effect and is slow in effect are solved;
5. the invention relies on plant extracts, has strong inhibition and killing effects on dozens of pathogenic microorganisms such as escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, candida albicans and the like, and has strong killing effects on gonococcus and chlamydia trachomatis which cause sexually transmitted diseases;
6. in the preparation of the nano silver antibacterial gel, the mixed solution is subjected to ultrasonic oscillation under the pressurizing condition, so that Ag+ is reduced better to generate Ag atoms;
7. the licorice root extract, the kuh-seng extract, the patrinia herb extract, the motherwort extract and the cordate houttuynia extract are subjected to freezing treatment, so that the effective components in the licorice root, the kuh-seng, the patrinia herb, the motherwort and the cordate houttuynia are fully reserved, the phenomenon of loss of the effective components in the processing and extracting process is avoided, the licorice root, the kuh-seng, the patrinia herb, the motherwort and the cordate houttuynia are subjected to freezing treatment in advance, even if the effective components in the licorice root, the kuh-seng, the patrinia herb, the motherwort and the cordate houttuynia are not lost after being crushed, the effective components in the licorice root, the kuh-seng, the patrinia herb, the motherwort and the cordate houttuynia are gradually discharged during the distillation operation, and the yield of the licorice root extract, the kuh-seng extract, the patrinia herb extract and the cordate houttuynia extract is improved by reducing the loss in the production process.
Drawings
FIG. 1 is a schematic diagram of the preparation steps of the medical gynecological gel of the invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The invention provides a novel medical gynecological gel shown in figure 1, which comprises the following components in parts by weight: 2 parts of licorice root extract, 3 parts of kuh-seng extract, 2 parts of herba patriniae extract, 3 parts of winter ash, 10 parts of motherwort extract, 15 parts of cordate houttuynia extract, 2 parts of wormwood essential oil, 80 parts of edible gelatin and 2 parts of nano silver antibacterial gel.
The synthesis steps of the nano silver antibacterial gel comprise:
s1: weighing a certain amount of silver nitrate, adding water for dissolution, and placing into a brown volumetric flask for standby;
s2: weighing a certain amount of water-soluble chitosan, adding water for dissolution to prepare a solution with a certain concentration, filtering, and placing in a closed bottle for standby;
s3: respectively taking glucose and chitosan aqueous solution according to the mass ratio of the silver nitrate, uniformly mixing, adding water, then adding the silver nitrate solution into the solution under stirring to ensure that the concentration of silver is 900ppm, placing the mixed solution into an ultrasonic oscillator, carrying out ultrasonic oscillation for 5Min under the pressure condition and the temperature range of 30 ℃, reducing Ag+ under the combined action of ultrasonic waves, chitosan and glucose to generate Ag atoms, and uniformly dispersing the Ag atoms in the chitosan colloid solution;
s4: the molar ratio of potassium borohydride to silver nitrate is as follows: 1.5, polyvinylpyrrolidone and silver nitrate with a mass ratio of 1:0.8, preparing nano silver colloid by ultrasonic oscillation for 15 min;
s5: weighing 500ml of distilled water, putting into a 1000ml beaker, opening stirring, weighing 5g of carbomer resin, slowly adding into a vortex of distilled water under rapid stirring to completely dissolve and disperse uniformly, adding 25 g of glycerol, stirring uniformly, neutralizing with triethanolamine to pH of about 6, adding nano silver sol to make the nano silver content be 100ppm, stirring uniformly, adding water to 500ml, and stirring uniformly to obtain the nano silver antibacterial gel.
The pressurizing condition in S3 is 0.1Mpa.
The medical gynecological gel comprises the following preparation steps:
step one, preparing a material A, namely mixing licorice root extract, radix sophorae flavescentis extract, herba patriniae extract, winter ash, motherwort extract and cordate houttuynia extract, and fully stirring to form the material A;
step two, preparing a material B, mixing the nano silver antibacterial gel and the edible gelatin, fully stirring to form the material B, and preparing the wormwood essential oil for later use;
and step three, mixing the material A and the material B, adding the mugwort essential oil uniformly, and stirring uniformly to obtain the medical gynecological gel.
The extraction steps of the licorice root extract, the kuh-seng extract, the herba patriniae extract, the motherwort extract and the cordate houttuynia extract are as follows:
a1: picking and cleaning, namely cleaning the picked licorice root, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia by clean water and draining for later use;
a2: c, freezing, namely weighing a certain amount of licorice roots, kuh-seng, herba patriniae, motherwort and cordate houttuynia obtained in the step A1, and freezing for 1h to be in a state of easy brittle fracture;
a3: crushing the frozen licorice roots, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia by using a crusher, keeping the crushing environment at low temperature, and crushing to form Wen Gancao roots, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia residues;
a4: distilling, namely transferring the low Wen Gancao root, kuh-seng, herba patriniae, motherwort and cordate houttuynia residues into a distillation kettle, wherein the distillation temperature is 50 ℃, the distillation time is 1.5h, and cooling to obtain an oil-water mixture;
a5: separating oil and water, separating oil-water mixture in a standing separator, collecting the upper layer of Glycyrrhrizae radix, radix Sophorae Flavescentis, herba Patriniae, herba Leonuri, and herba Houttuyniae extract, and the lower layer of water containing small amount of Glycyrrhrizae radix, radix Sophorae Flavescentis, herba Patriniae, herba Leonuri, and herba Houttuyniae extract, and distilling again in a distilling kettle.
It is to be noted that bacterial virus is an organic organism, and its cell wall and cell membrane are composed of phospholipid bilayer membrane, and have negative charge; while silver carries a very active cation, i.e. a positive charge. Silver has its bactericidal effect expressed in physics as "like charges repel each other and opposite charges attract each other". When silver releases a large amount of positive charges on its material surface, bacteria or other organic organisms bearing negative charges are attracted to its surface. After the positive and negative charges react, the respiration of bacteria is inhibited, and the cell walls and cell membranes of the bacteria are thoroughly deformed and ruptured, so that the reproduction and viability are lost, and the 'dissolving death' occurs. In addition, the silver ion has a super-strong degradation function, when bacteria are absorbed on the surface of silver, the super-strong degradation function of the silver ion can destroy an enzyme system in cells, and the normal metabolism of the bacteria is affected, so that the bacteria die. The general antibiotics can only play a role on 6 germs on average, but silver can kill 650 germs. Therefore, the sterilization principle of silver is not a physical method which does not damage human and environment, so the mode of using the nano silver antibacterial gel can have strong inhibition and sterilization effects on virus strains, does not damage human and environment, and the nano silver antibacterial gel is combined with licorice root extract, radix sophorae flavescentis extract, herba patriniae extract, winter ash, motherwort extract and cordate houttuynia extract, so that the effective components of the medicament are fully attached to the skin surface of a patient.
Example 2
The invention provides a novel medical gynecological gel shown in figure 1, which comprises the following components in parts by weight: 5 parts of licorice root extract, 5 parts of radix sophorae flavescentis extract, 10 parts of herba patriniae extract, 5 parts of winter ash, 11 parts of motherwort extract, 20 parts of cordate houttuynia extract, 4 parts of wormwood essential oil, 80 parts of edible gelatin and 5 parts of nano silver antibacterial gel.
The synthesis steps of the nano silver antibacterial gel comprise:
s1: weighing a certain amount of silver nitrate, adding water for dissolution, and placing into a brown volumetric flask for standby;
s2: weighing a certain amount of water-soluble chitosan, adding water for dissolution to prepare a solution with a certain concentration, filtering, and placing in a closed bottle for standby;
s3: respectively taking glucose and chitosan aqueous solution according to the mass ratio of the silver nitrate, uniformly mixing, adding water, then adding the silver nitrate solution into the solution under stirring to ensure that the silver concentration is 950ppm, placing the mixed solution into an ultrasonic oscillator, carrying out ultrasonic oscillation for 8Min under the pressure condition and the temperature range of 32 ℃, reducing Ag+ under the combined action of ultrasonic waves, chitosan and glucose to generate Ag atoms, and uniformly dispersing in the chitosan colloid solution;
s4: the molar ratio of potassium borohydride to silver nitrate is as follows: 1.8, polyvinylpyrrolidone and silver nitrate with a mass ratio of 1:1.1, preparing nano silver colloid by ultrasonic oscillation for 20 min;
s5: weighing 500ml of distilled water, putting into a 1000ml beaker, opening stirring, weighing 5g of carbomer resin, slowly adding into a vortex of distilled water under rapid stirring to completely dissolve and disperse uniformly, adding 25 g of glycerol, stirring uniformly, neutralizing with triethanolamine to pH of about 6, adding nano silver sol to make the nano silver content be 100ppm, stirring uniformly, adding water to 500ml, and stirring uniformly to obtain the nano silver antibacterial gel.
The pressurizing condition in S3 is 0.2Mpa.
The medical gynecological gel comprises the following preparation steps:
step one, preparing a material A, namely mixing licorice root extract, radix sophorae flavescentis extract, herba patriniae extract, winter ash, motherwort extract and cordate houttuynia extract, and fully stirring to form the material A;
step two, preparing a material B, mixing the nano silver antibacterial gel and the edible gelatin, fully stirring to form the material B, and preparing the wormwood essential oil for later use;
and step three, mixing the material A and the material B, adding the mugwort essential oil uniformly, and stirring uniformly to obtain the medical gynecological gel.
The extraction steps of the licorice root extract, the kuh-seng extract, the herba patriniae extract, the motherwort extract and the cordate houttuynia extract are as follows:
a1: picking and cleaning, namely cleaning the picked licorice root, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia by clean water and draining for later use;
a2: c, freezing, namely weighing a certain amount of licorice roots, kuh-seng, herba patriniae, motherwort and cordate houttuynia obtained in the step A1, freezing for 3 hours, and freezing into a state of easy brittle fracture;
a3: crushing the frozen licorice roots, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia by using a crusher, keeping the crushing environment at low temperature, and crushing to form Wen Gancao roots, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia residues;
a4: distilling, namely transferring the low Wen Gancao root, kuh-seng, herba patriniae, motherwort and cordate houttuynia residues into a distillation kettle, distilling at 80 ℃ for 2 hours, and cooling to obtain an oil-water mixture;
a5: separating oil and water, separating oil-water mixture in a standing separator, collecting the upper layer of Glycyrrhrizae radix, radix Sophorae Flavescentis, herba Patriniae, herba Leonuri, and herba Houttuyniae extract, and the lower layer of water containing small amount of Glycyrrhrizae radix, radix Sophorae Flavescentis, herba Patriniae, herba Leonuri, and herba Houttuyniae extract, and distilling again in a distilling kettle.
Example 3
The invention provides a novel medical gynecological gel shown in figure 1, which comprises the following components in parts by weight: 18 parts of licorice root extract, 15 parts of kuh-seng extract, 17 parts of herba patriniae extract, 7 parts of winter ash, 14 parts of motherwort extract, 30 parts of cordate houttuynia extract, 5 parts of wormwood essential oil, 80 parts of edible gelatin and 10 parts of nano silver antibacterial gel.
The synthesis steps of the nano silver antibacterial gel comprise:
s1: weighing a certain amount of silver nitrate, adding water for dissolution, and placing into a brown volumetric flask for standby;
s2: weighing a certain amount of water-soluble chitosan, adding water for dissolution to prepare a solution with a certain concentration, filtering, and placing in a closed bottle for standby;
s3: respectively taking glucose and chitosan aqueous solution according to the mass ratio of the silver nitrate, uniformly mixing, adding water, then adding the silver nitrate solution into the solution under stirring to ensure that the concentration of silver is 1000ppm, placing the mixed solution into an ultrasonic oscillator, carrying out ultrasonic oscillation for 8Min under the pressure condition and the temperature range of 33 ℃, reducing Ag+ under the combined action of ultrasonic waves, chitosan and glucose to generate Ag atoms, and uniformly dispersing the Ag atoms into the chitosan colloid solution;
s4: the molar ratio of potassium borohydride to silver nitrate is as follows: 2. the mass ratio of polyvinylpyrrolidone to silver nitrate is 1:1.2, preparing nano silver colloid by ultrasonic oscillation for 20 min;
s5: weighing 500ml of distilled water, putting into a 1000ml beaker, opening stirring, weighing 5g of carbomer resin, slowly adding into a vortex of distilled water under rapid stirring to completely dissolve and disperse uniformly, adding 25 g of glycerol, stirring uniformly, neutralizing with triethanolamine to pH of about 6, adding nano silver sol to make the nano silver content be 100ppm, stirring uniformly, adding water to 500ml, and stirring uniformly to obtain the nano silver antibacterial gel.
The pressurizing condition in S3 is 0.8Mpa.
The medical gynecological gel comprises the following preparation steps:
step one, preparing a material A, namely mixing licorice root extract, radix sophorae flavescentis extract, herba patriniae extract, winter ash, motherwort extract and cordate houttuynia extract, and fully stirring to form the material A;
step two, preparing a material B, mixing the nano silver antibacterial gel and the edible gelatin, fully stirring to form the material B, and preparing the wormwood essential oil for later use;
and step three, mixing the material A and the material B, adding the mugwort essential oil uniformly, and stirring uniformly to obtain the medical gynecological gel.
The extraction steps of the licorice root extract, the kuh-seng extract, the herba patriniae extract, the motherwort extract and the cordate houttuynia extract are as follows:
a1: picking and cleaning, namely cleaning the picked licorice root, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia by clean water and draining for later use;
a2: c, freezing, namely weighing a certain amount of licorice roots, kuh-seng, herba patriniae, motherwort and cordate houttuynia obtained in the step A1, freezing for 2 hours, and freezing into a state easy to be broken;
a3: crushing the frozen licorice roots, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia by using a crusher, keeping the crushing environment at low temperature, and crushing to form Wen Gancao roots, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia residues;
a4: distilling, namely transferring the low Wen Gancao root, kuh-seng, patrinia herb, motherwort herb and cordate houttuynia slag into a distillation kettle, distilling at 180 ℃ for 3 hours, and cooling to obtain an oil-water mixture;
a5: separating oil and water, separating oil-water mixture in a standing separator, collecting the upper layer of Glycyrrhrizae radix, radix Sophorae Flavescentis, herba Patriniae, herba Leonuri, and herba Houttuyniae extract, and the lower layer of water containing small amount of Glycyrrhrizae radix, radix Sophorae Flavescentis, herba Patriniae, herba Leonuri, and herba Houttuyniae extract, and distilling again in a distilling kettle.
Example 4
The invention provides a novel medical gynecological gel shown in figure 1, which comprises the following components in parts by weight: 20 parts of licorice root extract, 18 parts of radix sophorae flavescentis extract, 19 parts of herba patriniae extract, 8 parts of winter ash, 15 parts of motherwort extract, 35 parts of cordate houttuynia extract, 6 parts of wormwood essential oil, 80 parts of edible gelatin and 13 parts of nano silver antibacterial gel.
The synthesis steps of the nano silver antibacterial gel comprise:
s1: weighing a certain amount of silver nitrate, adding water for dissolution, and placing into a brown volumetric flask for standby;
s2: weighing a certain amount of water-soluble chitosan, adding water for dissolution to prepare a solution with a certain concentration, filtering, and placing in a closed bottle for standby;
s3: respectively taking glucose and chitosan aqueous solution according to the mass ratio of the silver nitrate, uniformly mixing, adding water, then adding the silver nitrate solution into the solution under stirring to ensure that the silver concentration is 1100ppm, placing the mixed solution into an ultrasonic oscillator, carrying out ultrasonic oscillation for 10Min under the pressure condition and the temperature range of 35 ℃, reducing Ag+ under the combined action of ultrasonic waves, chitosan and glucose to generate Ag atoms, and uniformly dispersing in the chitosan colloid solution;
s4: the molar ratio of potassium borohydride to silver nitrate is as follows: 3. the mass ratio of polyvinylpyrrolidone to silver nitrate is 1:1.5, preparing nano silver colloid by ultrasonic oscillation for 40 min;
s5: weighing 500ml of distilled water, putting into a 1000ml beaker, opening stirring, weighing 5g of carbomer resin, slowly adding into a vortex of distilled water under rapid stirring to completely dissolve and disperse uniformly, adding 25 g of glycerol, stirring uniformly, neutralizing with triethanolamine to pH of about 6, adding nano silver sol to make the nano silver content be 100ppm, stirring uniformly, adding water to 500ml, and stirring uniformly to obtain the nano silver antibacterial gel.
The pressurizing condition in S3 is 1Mpa.
The medical gynecological gel comprises the following preparation steps:
step one, preparing a material A, namely mixing licorice root extract, radix sophorae flavescentis extract, herba patriniae extract, winter ash, motherwort extract and cordate houttuynia extract, and fully stirring to form the material A;
step two, preparing a material B, mixing the nano silver antibacterial gel and the edible gelatin, fully stirring to form the material B, and preparing the wormwood essential oil for later use;
and step three, mixing the material A and the material B, adding the mugwort essential oil uniformly, and stirring uniformly to obtain the medical gynecological gel.
The extraction steps of the licorice root extract, the kuh-seng extract, the herba patriniae extract, the motherwort extract and the cordate houttuynia extract are as follows:
a1: picking and cleaning, namely cleaning the picked licorice root, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia by clean water and draining for later use;
a2: c, freezing, namely weighing a certain amount of licorice roots, kuh-seng, herba patriniae, motherwort and cordate houttuynia obtained in the step A1, freezing for 3 hours, and freezing into a state of easy brittle fracture;
a3: crushing the frozen licorice roots, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia by using a crusher, keeping the crushing environment at low temperature, and crushing to form Wen Gancao roots, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia residues;
a4: distilling, namely transferring the low Wen Gancao root, kuh-seng, patrinia herb, motherwort herb and cordate houttuynia slag into a distillation kettle, distilling at 200 ℃ for 4 hours, and cooling to obtain an oil-water mixture;
a5: separating oil and water, separating oil-water mixture in a standing separator, collecting the upper layer of Glycyrrhrizae radix, radix Sophorae Flavescentis, herba Patriniae, herba Leonuri, and herba Houttuyniae extract, and the lower layer of water containing small amount of Glycyrrhrizae radix, radix Sophorae Flavescentis, herba Patriniae, herba Leonuri, and herba Houttuyniae extract, and distilling again in a distilling kettle.

Claims (9)

1. A novel medical gynecological gel, which is characterized in that: comprises the following components in parts by weight: 2 to 20 parts of licorice root extract, 3 to 18 parts of kuh-seng extract, 2 to 19 parts of herba patriniae extract, 3 to 8 parts of winter ash, 10 to 15 parts of motherwort extract, 15 to 35 parts of cordate houttuynia extract, 2 to 6 parts of wormwood essential oil, 80 parts of edible gelatin and 2 to 13 parts of nano silver antibacterial gel.
2. A novel medical gynecological gel according to claim 1, wherein: the synthesis steps of the nano silver antibacterial gel comprise:
s1: weighing a certain amount of silver nitrate, adding water for dissolution, and placing into a brown volumetric flask for standby;
s2: weighing a certain amount of water-soluble chitosan, adding water for dissolution to prepare a solution with a certain concentration, filtering, and placing in a closed bottle for standby;
s3: respectively taking glucose and chitosan aqueous solution according to the mass ratio of the silver nitrate, uniformly mixing, adding water, then adding the silver nitrate solution into the solution under stirring to ensure that the concentration of silver is 900-1100ppm, placing the mixed solution into an ultrasonic oscillator, carrying out ultrasonic oscillation for 5-10Min under the condition of pressurization and the temperature range of 30-35 ℃, reducing Ag+ under the combined action of ultrasonic waves, chitosan and glucose to generate Ag atoms, and uniformly dispersing the Ag atoms in the chitosan colloid solution;
s4: the molar ratio of potassium borohydride to silver nitrate is as follows: 1.5 to 3, the mass ratio of polyvinylpyrrolidone to silver nitrate is 1:0.8 to 1.5, and carrying out ultrasonic oscillation for 15 to 40 minutes to prepare nano silver colloid;
s5: weighing 500ml of distilled water, putting into a 1000ml beaker, opening stirring, weighing 5g of carbomer resin, slowly adding into a vortex of distilled water under rapid stirring to completely dissolve and disperse uniformly, adding 25 g of glycerol, stirring uniformly, neutralizing with triethanolamine to pH of about 6, adding nano silver sol to make the nano silver content be 100ppm, stirring uniformly, adding water to 500ml, and stirring uniformly to obtain the nano silver antibacterial gel.
3. A novel medical gynecological gel as claimed in claim 2, wherein: the pressurizing condition in the step S3 is 0.1-1Mpa.
4. A novel medical gynecological gel according to claim 1, wherein: the medical gynecological gel comprises the following preparation steps:
step one, preparing a material A, namely mixing licorice root extract, radix sophorae flavescentis extract, herba patriniae extract, winter ash, motherwort extract and cordate houttuynia extract, and fully stirring to form the material A;
step two, preparing a material B, mixing the nano silver antibacterial gel and the edible gelatin, fully stirring to form the material B, and preparing the wormwood essential oil for later use;
and step three, mixing the material A and the material B, adding the mugwort essential oil uniformly, and stirring uniformly to obtain the medical gynecological gel.
5. A novel medical gynecological gel according to claim 1, wherein: the steps of extracting the licorice root extract, the lightyellow sophora root extract, the patrinia herb extract, the motherwort herb extract and the cordate houttuynia extract are as follows:
a1: picking and cleaning, namely cleaning the picked licorice root, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia by clean water and draining for later use;
a2: c, freezing, namely weighing a certain amount of licorice roots, kuh-seng, herba patriniae, motherwort and cordate houttuynia obtained in the step A1, freezing for 1-3 hours, and freezing into a state of easy brittle fracture;
a3: crushing the frozen licorice roots, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia by using a crusher, keeping the crushing environment at low temperature, and crushing to form Wen Gancao roots, the kuh-seng, the herba patriniae, the motherwort and the cordate houttuynia residues;
a4: distilling, namely transferring the low Wen Gancao root, kuh-seng, patrinia herb, motherwort herb and cordate houttuynia slag into a distillation kettle, distilling at 50-200 ℃ for 1.5-4 hours, and cooling to obtain an oil-water mixture;
a5: separating oil and water, separating oil-water mixture in a standing separator, collecting the upper layer of Glycyrrhrizae radix, radix Sophorae Flavescentis, herba Patriniae, herba Leonuri, and herba Houttuyniae extract, and the lower layer of water containing small amount of Glycyrrhrizae radix, radix Sophorae Flavescentis, herba Patriniae, herba Leonuri, and herba Houttuyniae extract, and distilling again in a distilling kettle.
6. A novel medical gynecological gel according to claim 1, wherein: comprises the following components in parts by weight: 2 parts of licorice root extract, 3 parts of kuh-seng extract, 2 parts of herba patriniae extract, 3 parts of winter ash, 10 parts of motherwort extract, 15 parts of cordate houttuynia extract, 2 parts of wormwood essential oil, 80 parts of edible gelatin and 2 parts of nano silver antibacterial gel.
7. A novel medical gynecological gel according to claim 1, wherein: comprises the following components in parts by weight: 5 parts of licorice root extract, 5 parts of radix sophorae flavescentis extract, 10 parts of herba patriniae extract, 5 parts of winter ash, 11 parts of motherwort extract, 20 parts of cordate houttuynia extract, 4 parts of wormwood essential oil, 80 parts of edible gelatin and 5 parts of nano silver antibacterial gel.
8. A novel medical gynecological gel according to claim 1, wherein: comprises the following components in parts by weight: 18 parts of licorice root extract, 15 parts of kuh-seng extract, 17 parts of herba patriniae extract, 7 parts of winter ash, 14 parts of motherwort extract, 30 parts of cordate houttuynia extract, 5 parts of wormwood essential oil, 80 parts of edible gelatin and 10 parts of nano silver antibacterial gel.
9. A novel medical gynecological gel according to claim 1, wherein: comprises the following components in parts by weight: 20 parts of licorice root extract, 18 parts of radix sophorae flavescentis extract, 19 parts of herba patriniae extract, 8 parts of winter ash, 15 parts of motherwort extract, 35 parts of cordate houttuynia extract, 6 parts of wormwood essential oil, 80 parts of edible gelatin and 13 parts of nano silver antibacterial gel.
CN202310575622.6A 2023-05-22 2023-05-22 Novel medical gynecological gel Withdrawn CN116392538A (en)

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