CN116374303B - Biological freeze-drying microsphere assembly device and biological freeze-drying microsphere assembly machine - Google Patents
Biological freeze-drying microsphere assembly device and biological freeze-drying microsphere assembly machine Download PDFInfo
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- CN116374303B CN116374303B CN202310553294.XA CN202310553294A CN116374303B CN 116374303 B CN116374303 B CN 116374303B CN 202310553294 A CN202310553294 A CN 202310553294A CN 116374303 B CN116374303 B CN 116374303B
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B35/00—Supplying, feeding, arranging or orientating articles to be packaged
- B65B35/30—Arranging and feeding articles in groups
- B65B35/44—Arranging and feeding articles in groups by endless belts or chains
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
- B65B31/04—Evacuating, pressurising or gasifying filled containers or wrappers by means of nozzles through which air or other gas, e.g. an inert gas, is withdrawn or supplied
- B65B31/06—Evacuating, pressurising or gasifying filled containers or wrappers by means of nozzles through which air or other gas, e.g. an inert gas, is withdrawn or supplied the nozzle being arranged for insertion into, and withdrawal from, the mouth of a filled container and operating in conjunction with means for sealing the container mouth
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B35/00—Supplying, feeding, arranging or orientating articles to be packaged
- B65B35/30—Arranging and feeding articles in groups
- B65B35/36—Arranging and feeding articles in groups by grippers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B35/00—Supplying, feeding, arranging or orientating articles to be packaged
- B65B35/30—Arranging and feeding articles in groups
- B65B35/46—Arranging and feeding articles in groups by rotary conveyors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
- B65B43/12—Feeding flexible bags or carton blanks in flat or collapsed state; Feeding flat bags connected to form a series or chain
- B65B43/14—Feeding individual bags or carton blanks from piles or magazines
- B65B43/16—Feeding individual bags or carton blanks from piles or magazines by grippers
- B65B43/18—Feeding individual bags or carton blanks from piles or magazines by grippers by suction-operated grippers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
- B65B43/26—Opening or distending bags; Opening, erecting, or setting-up boxes, cartons, or carton blanks
- B65B43/30—Opening or distending bags; Opening, erecting, or setting-up boxes, cartons, or carton blanks by grippers engaging opposed walls, e.g. suction-operated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B51/00—Devices for, or methods of, sealing or securing package folds or closures; Devices for gathering or twisting wrappers, or necks of bags
- B65B51/10—Applying or generating heat or pressure or combinations thereof
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The application provides a biological freeze-drying microsphere assembly device and a biological freeze-drying microsphere assembly machine. The biological freeze-dried microsphere assembling device comprises an assembling machine case, a chip feeding assembly, a freeze-dried microsphere split charging assembly and a freeze-dried reagent chip bagging assembly; the chip feeding assembly comprises a chip transplanting turntable, a chip transplanting piece and a plurality of material blocking pieces; the freeze-dried microsphere split charging assembly comprises a chip feeding conveyor belt and a plurality of biological freeze-dried microsphere feeding pieces, wherein the chip feeding conveyor belt is arranged on an assembly machine box; the freeze-drying reagent chip bagging assembly comprises a chip transfer conveying belt arranged on an assembly machine case and a bagging sealing piece. Each freeze-dried reagent chip is placed on the chip feeding conveyor belt through the chip transplanting piece respectively, so that quick feeding of the freeze-dried reagent chip is facilitated, a plurality of biological freeze-dried microsphere feeding pieces simultaneously place biological freeze-dried microspheres on the corresponding freeze-dried reagent chips, and the freeze-dried reagent chips with the biological freeze-dried microspheres are sealed in bags by the bagging sealing piece, so that the assembly efficiency of the biological freeze-dried microspheres is effectively improved.
Description
Technical Field
The invention relates to the technical field of freeze-dried balls, in particular to a biological freeze-dried microsphere assembly device and a biological freeze-dried ball assembly machine.
Background
At present, biological detection reagents are widely used in the fields of pharmacy, clinic, scientific research and the like and used for detecting bacterial endotoxin and fungal glucan, but the biological detection reagents are unstable and easy to pollute in a liquid state, and the biological detection reagents on the market at present are stored and transported after conventional vacuum freeze-drying treatment, namely, freeze-dried reagent microsphere structures are packaged and stored in biological freeze-dried reagent chips so as to be convenient for long-time storage.
However, the conventional packaging process of the freeze-dried reagent microsphere structure mainly relies on an artificial feeding method to feed the biological freeze-dried reagent chip, and after the chip packaged with the freeze-dried reagent microsphere structure is formed, the chip is further required to be manually packaged, which easily results in poor packaging efficiency of the chip.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides a biological freeze-dried microsphere assembling device and a biological freeze-dried microsphere assembling machine which can effectively improve the assembling efficiency of biological freeze-dried microspheres.
The aim of the invention is realized by the following technical scheme:
A biological lyophilization microsphere assembly device comprising: the assembly machine comprises an assembly machine case, a chip feeding assembly, a freeze-dried microsphere split charging assembly and a freeze-dried reagent chip bagging assembly; the chip feeding assembly comprises a chip transplanting rotary table, chip transplanting pieces and a plurality of blocking pieces, wherein the chip transplanting rotary table and the chip transplanting pieces are arranged on the assembly chassis, the blocking pieces are arranged on the chip transplanting rotary table, each blocking piece is used for limiting a plurality of freeze-dried reagent chips stacked and arranged, and the chip transplanting pieces are used for grabbing and moving the freeze-dried reagent chips; the freeze-dried microsphere split charging assembly comprises a chip feeding transmission belt and a plurality of biological freeze-dried microsphere feeding pieces, wherein the chip feeding transmission belt and the chip transplanting pieces are arranged on the assembly machine case, so that the chip transplanting pieces transplant the freeze-dried reagent chips onto the chip feeding transmission belt, and the biological freeze-dried microsphere feeding pieces are respectively distributed on two sides of the chip feeding transmission belt and are used for moving biological freeze-dried microspheres onto the freeze-dried reagent chips; the freeze-drying reagent chip bagging assembly comprises a chip material transferring conveying belt and a bagging sealing piece, wherein the chip material transferring conveying belt and the chip material feeding conveying belt are arranged on the assembly machine case in a corresponding mode, the chip material transferring conveying belt is used for conveying freeze-drying reagent chips output by the chip material feeding conveying belt, and the bagging end of the bagging sealing piece faces to the chip material transferring conveying belt and is used for bagging and sealing the freeze-drying reagent chips.
In one embodiment, each blocking piece comprises a stacking block and at least two blocking rods, each stacking block is arranged on the chip transplanting turntable, the at least two blocking rods are arranged on one stacking block, a stacking area is formed between the at least two blocking rods, and the stacking area is used for placing a plurality of stacked freeze-dried reagent chips.
In one embodiment, at least two material blocking rods on each material stacking block are oppositely arranged.
In one embodiment, the number of the blocking rods is four, wherein two blocking rods are oppositely arranged, and the other two blocking rods are oppositely arranged.
In one embodiment, the plurality of material blocking pieces are uniformly distributed on the chip transplanting turntable.
In one embodiment, the distances between any two adjacent material blocking pieces are equal, and the material blocking pieces are circumferentially distributed on the edge of the chip transplanting turntable.
In one embodiment, the assembly further comprises a cover piece attaching part, the cover piece attaching part comprises a cover piece flying device, a cover piece coil stock and a cover piece transferring manipulator, the cover piece flying device and the cover piece transferring manipulator are both arranged on the assembly case, the cover piece flying device is wound on a roller wheel, the cover piece flying device is further used for cutting a cover piece on the cover piece coil stock, and the cover piece transferring manipulator is used for transferring the cover piece onto a freeze-drying reagent chip on the chip feeding conveyor belt so as to seal biological freeze-drying microspheres on the freeze-drying reagent chip.
In one embodiment, the freeze-drying microsphere split charging assembly further comprises a first split transmission belt, a second split transmission belt and a silica gel cover split charging member, wherein the first split transmission belt and the second split transmission belt are both arranged on the assembly chassis, the cover sheet attaching member further comprises a product taking manipulator arranged on the assembly chassis, the product taking manipulator is positioned between the first split transmission belt and the chip feeding transmission belt, the product taking manipulator is used for grabbing freeze-drying reagent chips on the chip feeding transmission belt onto the first split transmission belt, the silica gel cover split charging member comprises a silica gel cover vibration disc, a silica gel cover direct vibration track, a silica gel cover vibration disc and a plurality of silica gel cover assembly manipulators, the silica gel cover vibration disc is used for integrally arranging special-shaped silica gel covers, the silica gel cover direct vibration track and the silica gel cover vibration disc are both arranged on the assembly chassis, the silica gel cover direct vibration track penetrates the silica gel cover discharge port of the silica gel cover disc, and the silica gel cover direct vibration track is used for grabbing the special-shaped silica gel cover on the first split transmission belt, and the silica gel cover vibration disc is used for grabbing the special-shaped silica gel cover on the first split transmission belt.
In one embodiment, the angle difference between the two adjacent silica gel cover assembling manipulators for rotating the special-shaped silica gel covers is equal.
A biological freeze-dried microsphere assembly machine comprising the biological freeze-dried microsphere assembly device according to any one of the above embodiments.
Compared with the prior art, the invention has at least the following advantages:
a plurality of freeze-dried reagent chips are stored on the chip transplanting turntable, each freeze-dried reagent chip is placed on the chip feeding conveying belt respectively through the chip transplanting piece, so that quick feeding of the freeze-dried reagent chips is facilitated, a plurality of biological freeze-dried microsphere feeding pieces simultaneously place biological freeze-dried microspheres on the corresponding freeze-dried reagent chips, the feeding efficiency of the biological freeze-dried microspheres is improved, the freeze-dried reagent chips with the biological freeze-dried microspheres are sealed in bags by the bagging sealing piece, finished products of the biological freeze-dried microspheres are packaged quickly, and the assembly efficiency of the biological freeze-dried microspheres is effectively improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a biological lyophilized microsphere assembly device according to one embodiment;
FIG. 2 is an enlarged schematic view of the assembly device for the biological lyophilization microspheres shown in FIG. 1 at A1;
FIG. 3 is a schematic diagram of a lyophilized microsphere dispensing assembly according to one embodiment;
FIG. 4 is a partial schematic view of a biological lyophilized microsphere loading member of the lyophilized microsphere dispensing assembly of FIG. 3;
FIG. 5 is a schematic view of the partial structure of FIG. 4 from another perspective;
FIG. 6 is an enlarged schematic view of the assembly device of the biological lyophilized microspheres of FIG. 1 at A2;
FIG. 7 is a schematic diagram of a lyophilized reagent chip bagging assembly according to one embodiment;
FIG. 8 is a schematic view of another perspective of the lyophilized reagent chip bagging assembly of FIG. 7;
FIG. 9 is an enlarged schematic view of the lyophilized reagent chip bagging assembly of FIG. 8 at B1;
FIG. 10 is a schematic view of a further view of the lyophilized reagent chip bagging assembly of FIG. 7;
FIG. 11 is an enlarged schematic view of the lyophilized reagent chip bagging assembly of FIG. 8 at B3;
FIG. 12 is an enlarged schematic view of the lyophilized reagent chip bagging assembly of FIG. 7 at B2;
fig. 13 is a schematic view of a heat sealer in the lyophilized reagent chip bagging assembly of fig. 7.
Detailed Description
In order that the invention may be readily understood, a more complete description of the invention will be rendered by reference to the appended drawings. The drawings illustrate preferred embodiments of the invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "fixed to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like are used herein for illustrative purposes only and are not meant to be the only embodiment.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
The invention relates to a biological freeze-drying microsphere assembly device. In one embodiment, the biological lyophilized microsphere assembly device comprises an assembly chassis, a chip loading assembly, a lyophilized microsphere sub-packaging assembly, and a lyophilized reagent chip bagging assembly; the chip feeding assembly comprises a chip transplanting rotary table, chip transplanting pieces and a plurality of blocking pieces, wherein the chip transplanting rotary table and the chip transplanting pieces are arranged on the assembly chassis, the blocking pieces are arranged on the chip transplanting rotary table, each blocking piece is used for limiting a plurality of freeze-dried reagent chips stacked and arranged, and the chip transplanting pieces are used for grabbing and moving the freeze-dried reagent chips; the freeze-dried microsphere split charging assembly comprises a chip feeding transmission belt and a plurality of biological freeze-dried microsphere feeding pieces, wherein the chip feeding transmission belt and the chip transplanting pieces are arranged on the assembly machine case, so that the chip transplanting pieces transplant the freeze-dried reagent chips onto the chip feeding transmission belt, and the biological freeze-dried microsphere feeding pieces are respectively distributed on two sides of the chip feeding transmission belt and are used for moving biological freeze-dried microspheres onto the freeze-dried reagent chips; the freeze-drying reagent chip bagging assembly comprises a chip material transferring conveying belt and a bagging sealing piece, wherein the chip material transferring conveying belt and the chip material feeding conveying belt are arranged on the assembly machine case in a corresponding mode, the chip material transferring conveying belt is used for conveying freeze-drying reagent chips output by the chip material feeding conveying belt, and the bagging end of the bagging sealing piece faces to the chip material transferring conveying belt and is used for bagging and sealing the freeze-drying reagent chips. A plurality of freeze-dried reagent chips are stored on the chip transplanting turntable, each freeze-dried reagent chip is placed on the chip feeding conveying belt respectively through the chip transplanting piece, so that quick feeding of the freeze-dried reagent chips is facilitated, a plurality of biological freeze-dried microsphere feeding pieces simultaneously place biological freeze-dried microspheres on the corresponding freeze-dried reagent chips, the feeding efficiency of the biological freeze-dried microspheres is improved, the freeze-dried reagent chips with the biological freeze-dried microspheres are sealed in bags by the bagging sealing piece, finished products of the biological freeze-dried microspheres are packaged quickly, and the assembly efficiency of the biological freeze-dried microspheres is effectively improved.
Fig. 1 is a schematic structural diagram of a biological lyophilized microsphere assembly device according to an embodiment of the invention.
The biological lyophilized microsphere assembly device 10 of one embodiment includes an assembly housing 100, a chip loading assembly 200, a lyophilized microsphere dispensing assembly 300, and a lyophilized reagent chip bagging assembly 400. The chip feeding assembly 200 includes a chip transplanting turntable 210, a chip transplanting member 220, and a plurality of material blocking members 230. The chip transplanting turntable 210 and the chip transplanting pieces 220 are both arranged on the assembly chassis 100, a plurality of material blocking pieces 230 are both arranged on the chip transplanting turntable 210, and each material blocking piece 230 is used for limiting a plurality of freeze-drying reagent chips stacked. The chip transplanting member 220 is used for grasping and moving the lyophilized reagent chip. The freeze-dried microsphere split charging assembly 300 comprises a chip feeding conveyor 310 arranged on the assembly chassis 100 and a plurality of biological freeze-dried microsphere feeding members 320. The chip feeding conveyor 310 is disposed corresponding to the chip transplanting member 220, so that the chip transplanting member 220 transplants the lyophilized reagent chip onto the chip feeding conveyor 310. The multiple biological freeze-dried microsphere loading pieces 320 are respectively distributed on two sides of the chip feeding conveyor 310, and are used for moving biological freeze-dried microspheres onto the freeze-dried reagent chips. The lyophilized reagent chip bagging assembly 400 includes a chip transfer conveyor 410 disposed on the assembly chassis 100 and a bagging seal 420. The chip transfer conveyor 410 is disposed corresponding to the chip feeding conveyor 310, and the chip transfer conveyor 410 is used for conveying the lyophilized reagent chips output by the chip feeding conveyor 310. The bagging end of the bagging closure 420 faces the chip transfer conveyor 410 for bagging and sealing the lyophilized reagent chips.
In this embodiment, a plurality of freeze-dried reagent chips are stored on the chip transplanting turntable 210, and each freeze-dried reagent chip is respectively placed on the chip feeding conveyor belt 310 through the chip transplanting piece 220, so that quick feeding of the freeze-dried reagent chips is facilitated, and a plurality of biological freeze-dried microsphere feeding pieces 320 simultaneously place biological freeze-dried microspheres on the corresponding freeze-dried reagent chips, so that the feeding efficiency of the biological freeze-dried microspheres is improved, and the freeze-dried reagent chips with the biological freeze-dried microspheres are sealed in bags by the bagging sealing piece 420, so that finished products of the biological freeze-dried microspheres are packaged quickly, and the assembly efficiency of the biological freeze-dried microspheres is effectively improved.
In one embodiment, referring to fig. 2, each of the blocking members 230 includes a stacking block 232 and at least two blocking rods 234, each stacking block 232 is disposed on the chip transplanting turntable 210, the at least two blocking rods 234 are disposed on one stacking block 232, and a stacking area is formed between the at least two blocking rods 234, and the stacking area is used for placing a plurality of stacked freeze-dried reagent chips. In this embodiment, the stacking block 232 is located on the chip transplanting turntable 210, the stacking block 232 is used as a support base of the blocking rod 234, and the stacking block 232 is used to support the blocking rod 234. The stacking area is formed by surrounding at least two blocking rods 234, a plurality of freeze-drying reagent chips stacked are arranged in the stacking area, and the plurality of freeze-drying reagent chips are conveniently limited in the stacking area, so that the freeze-drying reagent chips are conveniently stored, and the chip transplanting piece 220 is conveniently and rapidly transferred onto the chip feeding conveying belt 310, and the feeding efficiency of the freeze-drying reagent chips is effectively improved.
Further, at least two blocking rods 234 on each stacking block 232 are disposed opposite to each other. In this embodiment, at least two blocking rods 234 are oppositely disposed, a stacking area is formed between at least two blocking rods 234, and in the stacking area, lyophilized reagent chips are disposed symmetrically about the stacking area, that is, at least two blocking rods 234 are disposed oppositely about the lyophilized reagent chips in the stacking area, so that two opposite ends of the lyophilized reagent chips are clamped by two blocking rods 234, thereby enabling a plurality of lyophilized reagent chips in the stacking area to be stably disposed, and facilitating placement of the plurality of stacked lyophilized reagent chips in the stacking area. In another embodiment, the number of the blocking rods 234 is four, wherein two blocking rods 234 are disposed opposite to each other, and the other two blocking rods 234 are disposed opposite to each other. Wherein two relatively arranged material blocking rods 234 clamp a plurality of freeze-dried reagent chips in one direction, and the other two relatively arranged material blocking rods 234 clamp a plurality of freeze-dried reagent chips in the other direction, specifically, the two directions are mutually perpendicular, so that the placement stability of the plurality of freeze-dried reagent chips in the stacking area is further improved.
In one embodiment, referring to fig. 2, a plurality of the stoppers 230 are uniformly distributed on the chip transplanting turntable 210. In this embodiment, the blocking member 230 is disposed on the chip transplanting turntable 210, and the blocking member 230 rotates the lyophilized reagent chip under the chip transplanting member 220 under the rotation of the chip transplanting turntable 210, so that the chip transplanting member 220 moves the lyophilized reagent chip onto the chip feeding conveyor 310. The material blocking members 230 are uniformly distributed on the chip transplanting turntable 210, so that the distribution of the material blocking members 230 on the chip transplanting turntable 210 is maximized, and the number of freeze-dried reagent chips stored on the chip transplanting turntable 210 is effectively increased.
Further, the distances between any two adjacent material blocking members 230 are equal, and a plurality of material blocking members 230 are circumferentially distributed on the edge of the chip transplanting turntable 210. In this embodiment, the plurality of material blocking members 230 form an annular structure on the chip transplanting turntable 210, that is, the plurality of material blocking members 230 are distributed on the chip transplanting turntable 210 in a surrounding manner, that is, the plurality of material blocking members 230 are uniformly distributed on the edge of the chip transplanting turntable 210. In this way, the material blocking members 230 on the chip transferring carousel 210 limit a plurality of the lyophilized reagent chips to the edge of the chip transferring carousel 210, so that the lyophilized reagent chips on each material blocking member 230 can be quickly transferred onto the chip feeding conveyor 310.
In another embodiment, the chip feeding assembly further comprises a chip position recognition camera, the chip position recognition camera is arranged on the assembly chassis, and a recognition collection end of the chip position recognition camera faces the chip transplanting turntable and is used for obtaining the position of each freeze-dried reagent chip on the chip transplanting turntable, so that the chip transplanting piece can conveniently transfer the freeze-dried reagent chips at the designated positions onto the chip feeding conveyor belt.
In one embodiment, referring to fig. 6, the lyophilized microsphere split-packaging assembly 300 further includes a cover sheet attaching member 330, the cover sheet attaching member 330 includes a cover sheet feeder 332, a cover sheet roll 334 and a cover sheet transferring manipulator 336, the cover sheet feeder 332 and the cover sheet transferring manipulator 336 are both disposed on the assembly chassis 100, the cover sheet roll 334 is wound on a roller of the cover sheet feeder 332, the cover sheet feeder 332 is further used for cutting a cover sheet on the cover sheet roll 334, and the cover sheet transferring manipulator 336 is used for transferring the cover sheet onto a lyophilized reagent chip on the chip feeding conveyor 310 so as to seal the biological lyophilized microspheres on the lyophilized reagent chip. In this embodiment, the cover sheet flying device 332 is used as a winding installation component of the cover sheet roll 334, so as to facilitate winding and releasing of the cover sheet roll 334. The cover sheet cut out of the cover sheet roll 334 is grasped and removed by the cover sheet transferring manipulator 336, so that the cover sheet is transferred onto the lyophilized reagent chip on the chip feeding conveyor 310, thereby facilitating the surface covering of the lyophilized reagent chip, and further facilitating the sealing of biological lyophilized microspheres.
Further, the freeze-dried microsphere split charging assembly 300 further comprises a first split transmission belt 340, a second split transmission belt 350 and a silica gel cover split charging member 360, the first split transmission belt 340 and the second split transmission belt 350 are both arranged on the assembly chassis 100, the cover sheet attaching member 330 further comprises a silicone rubber taking manipulator 338 arranged on the assembly chassis 100, the silicone rubber taking manipulator 338 is arranged between the first split transmission belt 340 and the chip feeding transmission belt 310, the silicone rubber taking manipulator 338 is used for grabbing a freeze-dried reagent chip on the chip feeding transmission belt 310 to the first split transmission belt 340, the silica gel cover split charging member 360 comprises a silica gel cover vibration disk 362, a silica gel cover direct vibration track 364, a silica gel cover manipulator 366 and a plurality of silica gel cover assembly manipulators 368, the silica gel cover vibration disk 362 is used for arraying silica gel covers, the silica gel cover direct vibration track 364, the silica gel cover manipulator 366 and the silica gel cover assembly manipulators 338 are arranged on the assembly chassis 100, the silica gel cover vibration disk is used for arraying the silica gel cover direct vibration track 364, and the silica gel cover is used for grabbing the silica gel cover by the first split transmission belt to the first split transmission belt guide rail 364, and the silica gel cover is used for grabbing the silica gel cover by the first split vibration disk and the silica gel cover guide rail 364. In this embodiment, the picking manipulator 338 moves the lyophilized reagent chips covered with the cover sheet onto the first diversion conveyor 340, so that a plurality of lyophilized reagent chips covered with the cover sheet are placed on the first diversion conveyor 340, and the silica gel cover picking manipulator 366 removes the shaped silica gel cover on the silica gel cover direct vibration track 364 and places the shaped silica gel cover on the second diversion conveyor 350, so that a plurality of shaped silica gel covers are placed on the second diversion conveyor 350. Each silica gel cover assembly manipulator 368 grabs one of the special-shaped silica gel covers and places the special-shaped silica gel cover on the lyophilized reagent chip of the second split transmission band 350, specifically, the special-shaped silica gel cover is located on a cover plate on the lyophilized reagent chip. Each silica gel cover assembly manipulator 368 is right the dysmorphism silica gel cover rotates, in order to adjust the gesture of dysmorphism silica gel cover makes the dysmorphism silica gel cover is in the position on the freeze-drying reagent chip is different, is convenient for form a plurality of different dysmorphism silica gel covers of putting the gesture on the freeze-drying reagent chip.
Further, the two adjacent silica gel cover assembly manipulators rotate the angle difference of the special-shaped silica gel covers is equal. In this embodiment, a plurality of special-shaped silica gel covers pass through silica gel cover assembly robot place in with the angle of putting of difference on the freeze-drying reagent chip, moreover, adjacent two difference between the angle of putting of special-shaped silica gel cover is equal, is convenient for right the angle of putting on the freeze-drying reagent chip is divided equally, makes a plurality of special-shaped silica gel covers on the freeze-drying reagent chip link to distribute, specifically, when the special-shaped silica gel cover on the freeze-drying reagent chip is 3, adjacent two the silica gel cover assembly robot is rotatory the angle difference of special-shaped silica gel cover is 120.
When the freeze-dried reagent chip is actually packaged, particularly in the sucking process, surface desquamation of freeze-dried reagent microspheres can occur to block the sucking holes, so that the conventional vacuum adsorption device often fails in the taking and placing process, and the split charging efficiency of the freeze-dried reagent microspheres is affected.
In another embodiment, the cover sheet attaching member further comprises a chip detecting camera and a cover sheet detecting camera, wherein the detecting end of the cover sheet detecting camera faces the cover sheet coil stock to obtain the positions of the cut cover sheets, so that the picking manipulator can pick the cover sheets one by one; the detection end of the chip detection camera faces to the chip feeding conveying belt to acquire the position of the freeze-dried reagent chip on the chip feeding conveying belt, so that the product taking manipulator attaches and places the cover plate on the freeze-dried reagent chip.
The application also provides a freeze-dried microsphere split charging assembly, referring to fig. 3, which is a schematic structural diagram of the freeze-dried microsphere split charging assembly according to an embodiment of the application.
The lyophilized microsphere dispensing assembly 300 of one embodiment includes a dispensing base 370, a chip feed conveyor 310, and a plurality of biological lyophilized microsphere loading members 320. The chip feeding conveyor 310 is disposed on the sub-packaging base 370, and the chip feeding conveyor 310 is used for conveying lyophilized reagent chips. The biological freeze-dried microsphere loading pieces 320 are respectively distributed on two sides of the chip feeding conveyor 310, and the biological freeze-dried microsphere loading pieces 320 comprise a loading slide rail 322, a microsphere loading flexible disc 324, a loading moving piece 326 and a microsphere loading suction rod 328. The loading slide rail 322 and the microsphere loading flexible disc 324 are both arranged on the sub-packaging base 370, and the microsphere loading flexible disc 324 is used for accommodating biological freeze-dried microspheres. The feeding moving member 326 is slidably disposed on the feeding sliding rail 322, so that the feeding moving member 326 moves along the feeding direction. The microsphere loading suction rod 328 is connected with the loading moving member 326, and the microsphere loading suction rod 328 is used for communicating with a vacuum blowing and sucking device so as to suck the biological freeze-dried microspheres in the microsphere loading flexible disc 324 onto the freeze-dried reagent chip.
In this embodiment, after the biological freeze-dried microsphere is sucked for a designated number of times, the atmospheric pressure released by the vacuum blower cleans the chips in the microsphere-containing suction rod 328, so that the probability that the microsphere-containing suction rod 328 is blocked by the desquamation on the surface of the biological freeze-dried microsphere is reduced, the blocking condition of the microsphere-containing suction rod 328 in the sucking process is effectively avoided, and the split charging efficiency of the biological freeze-dried microsphere is effectively improved. Wherein, the partial shipment base is placed on the assembly machine case.
In one embodiment, referring to fig. 3, the feeding moving member 326 includes a first moving member 326a, a second moving member 326b, and a third moving member 326c, where the first moving member 326a is slidably disposed on the feeding rail 322, so that the first moving member 326a moves along a first feeding direction, the second moving member 326b is slidably connected to the first moving member 326a, so that the second moving member 326b moves along a second feeding direction, and the third moving member 326c is slidably connected to the second moving member 326b, so that the third moving member 326c moves along a third feeding direction, and the third moving member 326c is further connected to the microsphere-containing suction rod 328. In this embodiment, the first moving member 326a moves along the direction of the feeding rail 322, and the extending direction of the feeding rail 322 is the same as the first feeding direction, so that the first moving member 326a can move in the first feeding direction. The second moving member 326b slides on the first moving member 326a, that is, the second moving member 326b moves along the extending direction of the first moving member 326a, so that the second moving member 326b has a moving component in both the first feeding direction and the second feeding direction. The third moving member 326c slides on the second moving member 326b, that is, the third moving member 326c moves along the extending direction of the second moving member 326b, so that the third moving member 326c has moving components in the first feeding direction, the second feeding direction and the third feeding direction, which facilitates the multidirectional movement of the microsphere-containing suction rod 328 connected to the third moving member 326c, thereby facilitating the movement of the microsphere-containing suction rod 328 in the opposite angle, and further facilitating the accurate suction of the biological freeze-dried microspheres by the microsphere-containing suction rod 328 into the receiving hole of the freeze-dried reagent chip, where the receiving hole is used for receiving the biological freeze-dried microspheres.
In another embodiment, the freeze-dried microsphere split charging assembly further comprises a microsphere feeding detection CCD camera and a microsphere shortage detection CCD camera, wherein the collection end of the microsphere feeding detection CCD camera faces to the chip feeding transmission belt so as to obtain a feeding image of the biological freeze-dried microsphere on the freeze-dried reagent chip, and the collection end of the microsphere shortage detection CCD camera faces to the microsphere feeding flexible disc so as to obtain a residual microsphere image of the biological freeze-dried microsphere in the microsphere feeding flexible disc. Therefore, after the microsphere feeding detection CCD camera collects the feeding image, whether the feeding on the freeze-dried reagent chip is finished or not is conveniently determined, namely whether biological freeze-dried microspheres exist on the freeze-dried reagent chip or not is determined. After the microsphere shortage detection CCD camera collects the images of the residual microspheres, the residual ball number of the biological freeze-dried microspheres in the microsphere feeding flexible disc can be conveniently determined, so that whether the microsphere feeding flexible disc is in shortage or not can be conveniently determined.
Further, at least two of the first feeding direction, the second feeding direction and the third feeding direction are perpendicular to each other. In another embodiment, the first feeding direction, the second feeding direction and the third feeding direction are perpendicular to each other, specifically, the first feeding direction is an X-axis direction, the second feeding direction is a Y-axis direction, and the third feeding direction is a Z-axis direction, so that the microsphere-containing suction rod 328 can move in the three-axis direction, so as to improve the accuracy of the microsphere-containing suction rod 328 in packing the biological freeze-dried microspheres.
In one embodiment, referring to fig. 3 and 4, the first moving member 326a includes a first sliding table 3261, a first protection drag chain 3262, a feeding moving motor 3263, and a feeding moving screw 3264, the first sliding table 3261 is slidably disposed on the feeding sliding rail 322, the first protection drag chain 3262 is connected with the first sliding table 3261, the feeding moving motor 3263 is disposed on the first sliding table 3261, an output shaft of the feeding moving motor 3263 is connected with the feeding moving screw 3264, and the second moving member 326b is slidably disposed on the feeding moving screw 3264. In this embodiment, the first sliding table 3261 slides along the feeding sliding rail 322, and the first protection drag chain 3262 serves as a protection chain for the first sliding table 3261, so as to prevent the first sliding table 3261 from being separated from the feeding sliding rail 322. The feeding moving motor 3263 is fixed on the first sliding table 3261, the feeding moving motor 3263 moves along with the first sliding table 3261, the feeding moving screw 3264 is connected with an output shaft of the feeding moving motor 3263, and the second moving member 326b is arranged on the feeding moving screw 3264, so that the second moving member 326b can move along the feeding sliding rail 322 when sliding on the feeding moving screw 3264, and the second moving member 326b can move in both a first feeding direction and a second feeding direction. In another embodiment, the first sliding table 3261 includes a driving motor and a sliding block, where the driving motor is used as a power source of the sliding block to drive the sliding block to slide on the feeding sliding rail 322, so that the sliding block drives the feeding moving motor 3263 to move.
Further, referring to fig. 3 and 4, the second moving member 326b includes a second sliding table 3265 and a second protective drag chain 3266, the second sliding table 3265 is slidably connected with the feeding moving screw 3264, the second sliding table 3265 is further connected with the third moving member 326c, and the second protective drag chain 3266 is connected with the second sliding table 3265. In this embodiment, the second sliding table 3265 is slidably disposed on the feeding moving screw 3264, and the feeding moving motor 3263 rotates the feeding moving screw 3264, so that the second sliding table 3265 and the feeding moving screw 3264 move relatively, and the second sliding table 3265 is convenient to move along the extending direction of the feeding moving screw 3264. The second protection drag chain 3266 is connected with the second sliding table 3265, the second protection drag chain 3266 serves as a movement protection chain of the second sliding table 3265, so that the situation that the second sliding table 3265 slides excessively on the feeding movable screw rod 3264 is avoided, and the sliding range of the second sliding table 3265 is effectively protected.
Still further, referring to fig. 4 and 5, the third moving member 326c includes a third sliding table 3267 and a first moving cylinder 3268, the first moving cylinder 3268 is connected to the second sliding table 3265, a moving end of the first moving cylinder 3268 is connected to the third sliding table 3267, and the microsphere-containing suction rod 328 is disposed on the third sliding table 3267. In this embodiment, the third sliding table 3267 is slidably disposed on the second sliding table 3265, and the first moving cylinder 3268 provides driving for the third sliding table 3267, so that the third sliding table 3267 slides on the second sliding table 3265, and the third sliding table 3267 drives the microsphere-containing suction rod 328 to slide together, so that the moving direction of the microsphere-containing suction rod 328 is conveniently adjusted, and the microsphere-containing suction rod 328 is enabled to move in the first feeding direction, the second feeding direction and the third feeding direction, so that the accuracy of capturing biological freeze-dried microspheres by the microsphere-containing suction rod 328 is improved.
Still further, referring to fig. 5, the second sliding table 3265 is provided with a sliding waist hole 302, the first moving cylinder 3268 is located on a surface of the second sliding table 3265 facing away from the microsphere-containing suction rod 328, and a moving end of the first moving cylinder 3268 is disposed in the sliding waist hole 302 in a penetrating manner and is connected to the third sliding table 3267. In this embodiment, the sliding waist-shaped hole 302 is formed on the second sliding table 3265, the moving end of the first moving cylinder 3268 is disposed in the sliding waist-shaped hole 302 in a penetrating manner, and the moving end of the first moving cylinder 3268 is connected with the third sliding table 3267, so as to facilitate moving the third sliding table 3267, so that the third sliding table 3267 moves on the surface of the second sliding table 3265.
Still further, referring to fig. 4, the third moving member 326c further includes a fine tuning sliding table 3269 and a second moving cylinder 3260, the second moving cylinder 3260 is fixed on the third sliding table 3267, a moving end of the second moving cylinder 3260 is connected to the fine tuning sliding table 3269, and the microsphere-containing suction rod 328 is connected to the fine tuning sliding table 3269. In this embodiment, the fine adjustment sliding table 3269 slides on the third sliding table 3267, and driven by the second moving cylinder 3260, the fine adjustment sliding table 3269 moves along the surface of the third sliding table 3267, so as to facilitate fine adjustment of the fine adjustment sliding table 3269, thereby facilitating more accurate adjustment of lifting of the microsphere-containing suction rod 328.
In one embodiment, referring to fig. 4, the bio-freeze-drying microsphere loading unit 320 further includes a suction rod vacuum nozzle 321 and a vacuum interface connector 323, wherein the suction rod vacuum nozzle 321 is in communication with the microsphere loading suction rod 328, the suction rod vacuum nozzle 321 is further in communication with a vacuum output interface of the vacuum interface connector 323, and a vacuum input interface of the vacuum interface connector 323 is in communication with the vacuum blower to provide positive and negative air pressure. In this embodiment, the suction rod vacuum nozzle 321 is correspondingly communicated with the microsphere-containing suction rod 328, and the suction rod vacuum nozzle 321 provides positive and negative air pressure for the microsphere-containing suction rod 328, so that negative pressure is provided when the biological freeze-dried microspheres are sucked, and positive pressure is provided when internal chips of the microsphere-containing suction rod 328 are cleaned. The vacuum interface connector 323 is communicated with the vacuum interface connector 323, so that the vacuum suction nozzle 321 of the suction rod can provide air pressure required by positive and negative pressure, corresponding air pressure can be conveniently output during suction and cleaning, and the blockage condition of the suction rod 328 for accommodating the microspheres can be avoided when the grabbing efficiency of the biological freeze-drying microspheres is improved.
After the freeze-dried reagent microspheres are packaged and stored in the biological freeze-dried reagent chip, the biological freeze-dried reagent chip is required to be packaged in an aluminum foil bag so as to produce the bagged freeze-dried tablet. However, the biological freeze-dried reagent chip is generally packaged, and after the opening of the aluminum foil bag is opened by manual operation, the biological freeze-dried reagent chip is placed in the bag, so that the production efficiency is low, the pollution risk existing after manual contact is easily caused, and even the detection accuracy of freeze-dried reagent microspheres in the biological freeze-dried reagent chip is reduced.
The application also provides a freeze-dried reagent chip bagging assembly, referring to fig. 7, which is a schematic structural diagram of the freeze-dried reagent chip bagging assembly according to an embodiment of the application.
The lyophilized reagent chip bagging assembly 400 of an embodiment includes a bagging base 440, a bagging conveyor belt, and a bagging seal 420. The bagging conveyor belt is disposed on the bagging base 440, and includes a chip transfer conveyor belt 410 and a bagging conveyor belt 430. The chip transferring conveyor belt 410 and the bagging conveyor belt 430 are staggered and arranged in parallel, the chip transferring conveyor belt 410 is used for conveying freeze-dried reagent chips, and the bagging conveyor belt 430 is used for conveying aluminum foil bags. Referring to fig. 8, the bag sealer 420 includes a core feeder 422, a bag expander 424, and a heat sealer 426. The core conveyer 422 and the heat sealer 426 are both disposed on the bagging base 440, and the core conveyer 422 corresponds to the chip transferring conveyor belt 410 and is configured to push the lyophilized reagent chips on the chip transferring conveyor belt 410 onto the bagging conveyor belt 430. The bag expander 424 is disposed at the edge of the bagging conveyor 430, and the bag expander 424 is used to expand the opening of the aluminum foil bag to load the freeze-dried reagent chip into the aluminum foil bag. The heat sealer 426 corresponds to the bagging conveyor belt 430 and is used for evacuating and filling nitrogen gas to seal the mouth of an aluminum foil bag filled with the freeze-dried reagent chips.
In this embodiment, before the freeze-dried reagent chip is sent into the aluminium foil bag, the bag expander 424 expands the opening of the aluminium foil bag for the opening of the aluminium foil bag struts, and the core conveyer 422 of being convenient for directly pushes the freeze-dried reagent chip into the aluminium foil bag, need not the manual work and opens the opening of the bag, has reduced the contact probability of freeze-dried reagent chip and staff, and when sealing, carries out evacuation and nitrogen filling to the aluminium foil bag, has reduced the pollution probability to freeze-dried reagent chip effectively. Wherein, the bagging base is placed on the assembly chassis.
In one embodiment, the chip transfer conveyor has a first core feeding region and the bagging conveyor has a second core feeding region, the first core feeding region being disposed opposite the second core feeding region. In this embodiment, the first core feeding area is located on the chip transferring conveyor belt, the second core feeding area is located on the bagging conveyor belt, specifically, the first core feeding area is located at the conveying end of the chip transferring conveyor belt, and the second core feeding area is located at a position close to the starting end of the bagging conveyor belt. The first core feeding area and the second core feeding area are correspondingly arranged, so that a chip discharging opening of the chip transferring and conveying belt corresponds to a chip feeding opening of the bagging conveying belt, and the chip transferring and conveying belt is convenient for the core feeder to accurately push freeze-dried reagent chips on the chip transferring and conveying belt into aluminum foil bags on the bagging conveying belt.
In another embodiment, the bag expander is disposed corresponding to the second core-feeding area, specifically, the bag expander is located on the second core-feeding area, so that the bag expander can open the opening of the aluminum foil bag moving to the second core-feeding area, and the freeze-dried reagent chip can be pushed into the aluminum foil bag just opened in the second core-feeding area in time.
In one embodiment, referring to fig. 9 and 10, the core feeder 422 includes a core feeding guide rail 4222, a core feeding motor 4224, and a core feeding push rod 4226, wherein the core feeding guide rail 4222 is disposed on the bagging base 440, the core feeding push rod 4226 is slidably disposed on the core feeding push rail 4222, the core feeding push rod 4226 corresponds to the first core feeding region, and the core feeding motor 4224 is used for driving the core feeding push rod 4226 to push the lyophilized reagent chip. In this embodiment, the core pushing rail 4222 is slidably provided with the core pushing rod 4226, and the core feeding motor 4224 is used as a driving motor of the core pushing rod 4226, so as to facilitate the movement of the core pushing rod 4226 on the core pushing rail 4222, thereby facilitating the core pushing rod 4226 to push the lyophilized reagent chip into the aluminum foil bag.
Further, referring to fig. 9, the chip transferring conveyor 410 is provided with a push rod opening 402, the push rod opening 402 is opposite to the first core feeding area, and the core feeding push rod 4226 movably penetrates the push rod opening 402. In this embodiment, the push rod opening 402 is formed at the edge of the chip transferring conveyor 410, and is used as a movable notch of the core feeding push rod 4226. The push rod opening 402 corresponds to the first core feeding area, and the push rod opening 402 is used for penetrating the core feeding push rod 4226, so that the core feeding push rod 4226 can conveniently enter and exit the chip transferring conveyor belt 410, and the core feeding push rod 4226 can conveniently push the freeze-dried reagent chip into the aluminum foil bag.
In one embodiment, referring to fig. 12, the bag expander 424 includes an upper bag opening suction cup 4242, a bag opening motor 4244, and a lower bag opening suction cup 4246, wherein the bag opening motor 4244 is disposed on the edge of the bag opening conveying belt 430, a lifting shaft of the bag opening motor 4244 is connected with the upper bag opening suction cup 4242, the lower bag opening suction cup 4246 is disposed on the edge of the bag opening conveying belt 430, and the lower bag opening suction cup 4246 is disposed opposite to the upper bag opening suction cup 4242 for expanding the bag opening of the aluminum foil bag. In this embodiment, the bag opening motor 4244 lifts the bag opening suction cup 4242, so that the bag opening suction cup 4242 is convenient to approach to and separate from the aluminum foil bag on the bag conveying belt 430, thereby facilitating the bag opening suction cup 4242 to suck the upper surface of the aluminum foil bag, and further facilitating the opening of the aluminum foil bag to be opened when the bag opening suction cup 4242 is separate from the bag conveying belt 430. The lower pulling bag suction cup 4246 is opposite to the upper pulling bag suction cup 4242, and the lower pulling bag suction cup 4246 is used for sucking the lower surface of the aluminum foil bag, so that the bag expander 424 expands the bag mouth of the aluminum foil bag to be large enough to ensure that the freeze-dried reagent chip can be accurately pushed into the aluminum foil bag.
Further, referring to fig. 12, the bag expander 424 further includes a bag pulling glue pressing block 4248, the bag pulling glue pressing block 4248 is connected to the upper bag pulling suction cup 4242, and the bag pulling glue pressing block 4248 is used for being in adhesive contact with the upper surface of the aluminum foil bag. In this embodiment, the bag pulling glue pressing block 4248 is located on one side of the upper pulling bag sucking disc 4242 near the bagging conveyor belt 430, when the upper pulling bag sucking disc 4242 approaches the aluminum foil bag, the bag pulling glue pressing block 4248 is in adhesive contact with the upper surface of the aluminum foil bag, so that when the upper pulling bag sucking disc 4242 sucks the upper surface of the aluminum foil bag and keeps away from the upper surface of the aluminum foil bag, the bag pulling glue pressing block 4248 pulls the upper surface of the aluminum foil bag up, so as to further increase the expansion opening size of the aluminum foil bag.
Still further referring to fig. 12, the bag expander 424 further includes a bag pressing barrier bar fixing block 4241, the bag pressing barrier bar fixing block 4241 is connected to the pull-up bag suction cup 4242, and the bag pressing barrier bar fixing block 4241 is used for limiting the freeze-dried reagent chip in the aluminum foil bag. In this embodiment, the bag pressing barrier bar fixing block 4241 is located on one side of the upper opening bag suction cup 4242, which is close to the bag packing conveyor belt 430, when the upper opening bag suction cup 4242 is close to the aluminum foil bag, the bag pressing barrier bar fixing block 4241 is in contact with the material pressing steel wire on the aluminum foil bag, so that when the upper opening bag suction cup 4242 is close to the upper surface of the aluminum foil bag, the bag pressing barrier bar fixing block 4241 limits the freeze-dried reagent chip in the aluminum foil bag, so as to prevent the freeze-dried reagent chip in the bag from sliding out in the moving process, and facilitate the subsequent sealing of the aluminum foil bag.
In one embodiment, referring to fig. 11, the bag sealing member 420 further includes a bag taking device 428, the bag taking device 428 includes a bag taking bracket 4281, a bag taking clip 4282, a bag taking rotating motor 4283, a bag taking rotating swing arm 4284, a bag taking and distributing fixed shaft 4285, a bag taking and distributing rod 4286, a bag taking and distributing sucker 4287, a bag taking and overturning slide 4288 and a bag taking and overturning guide rail 4289, the bag taking bracket 4281 is disposed on the bag taking base 440, the bag taking clip 4282 is connected with the bag taking bracket 4281, a bag taking opening of the bag taking clip 4282 is inclined towards the bag conveying belt 430, the bag taking clip 4282 is used for storing an aluminum foil bag, the bag taking and overturning motor 4283 is connected with the bag taking bracket 4281, a rotating shaft 4283 is fixedly connected with the bag taking and distributing fixed shaft 4284, the bag taking and overturning fixed shaft 4284 is further rotatably connected with the bag taking and distributing fixed shaft 4285, the bag taking and distributing rod 4286 is fixedly connected with the bag taking and overturning fixed shaft 4285, the bag taking and overturning slide 4282 is disposed on the bag taking and distributing rod 4288, the bag taking and overturning guide rail 4282 is further connected with the bag taking and overturning fixed shaft 4282. In this embodiment, the bag taking rack 4281 is obliquely provided with the bag taking clip 4282, and the bag taking clip 4282 is obliquely disposed with respect to the bag conveying belt 430, so that the aluminum foil bag in the bag taking clip 4282 can automatically descend and supplement under the action of gravity, thereby facilitating the next taking of the aluminum foil bag. The bag taking rotating motor 4283 is used for rotating the bag taking rotating swing arm 4284, so that the bag taking rotating swing arm 4284 rotates by taking the rotating shaft of the bag taking rotating motor 4283 as the center, the bag taking and distributing fixed shaft 4285 is rotationally connected with the bag taking rotating swing arm 4284, the bag taking and distributing fixed shaft 4285 is convenient to rotate relative to the bag taking rotating swing arm 4284, when the bag taking rotating swing arm 4284 ascends towards the bag taking support 4281, the bag taking and distributing fixed shaft 4285 slides along the bag taking and overturning guide rail 4289, the bag taking and overturning guide rail 4289 is rotationally connected with the bag taking support 4281, the bag taking and distributing fixed shaft 4285 overturns relative to the bag taking rotating swing arm 4284, the bag taking and distributing rod 4286 overturns together, the bag taking and distributing sucker 4287 overturns towards the bag taking elastic clip 4282, and the bag taking and distributing sucker 4287 absorbs the bag. After that, the bag taking rotating motor 4283 drives the bag taking rotating swing arm 4284 to reversely rotate, so that the bag taking and distributing sucker 4287 is restored to the original position, and the aluminum foil bag is conveniently placed on the bag conveying belt 430, so that the bag taking operation of the aluminum foil bag is realized. In another embodiment, the bag extractor 428 is disposed near the start end of the bagging conveyor 430, and the bag expander 424 is located at a subsequent station of the bagging conveyor 430, i.e., in the direction of conveyance of the bagging conveyor 430, the bag extractor 428, the bag expander 424, and the heat sealer 426 are sequentially disposed.
In one embodiment, referring to fig. 13, the heat sealer 426 includes a vacuum nitrogen-filling nozzle 4261, a top pouch clamping block 4262, a bottom pouch clamping block 4263, a top heat-sealing die 4264, a bottom heat-sealing die 4265, a top die thermocouple 4266, a bottom die thermocouple 4267, a top sealing die rod 4268, a bottom sealing die rod 4269, a sealing die guide rail 426a, a sealing head adjustment rail 426b, a pouch clamping cylinder 426c, and a sealing cylinder 426d, the vacuum nitrogen-filling nozzle 4261 is located between the top pouch clamping block 4262 and the bottom pouch clamping block 4263, the vacuum nitrogen-filling nozzle 4261 is used for evacuating and filling nitrogen into the aluminum foil pouch, the top pouch clamping block 4262 is connected to the top heat-sealing die 4264, the bottom pouch clamping block 4263 is connected to the bottom heat-sealing die 4265, the top die thermocouple 4266 is disposed on the top heat-sealing die 4264 for heating the top heat-sealing die 4264, the lower die thermocouple 4267 is disposed on the lower heat-seal die 4265 to heat the lower heat-seal die 4265, the upper heat-seal die 4264 and the lower heat-seal die 4265 are respectively connected with the outlet shaft of the sealing cylinder 426c to drive the upper heat-seal die 4264 and the lower heat-seal die 4265 to clamp or unclamp the mouth of the aluminum foil bag, the upper heat-seal die 4264 and the lower heat-seal die 4265 are respectively connected with the sealing die guide rail 426a, the upper sealing die rod 4268 and the lower sealing die rod 4269 are respectively slidably disposed on the sealing die guide rail 426a, the upper sealing die rod 4268 and the lower sealing die rod 4269 are respectively connected with the outlet shaft of the sealing cylinder 426d, the sealing cylinder 426d is used to drive the upper sealing die rod 4268 to press the upper die 4264 and the lower sealing die rod 4269 to lift the lower sealing die rod 4265, the seal head adjusting guide rail 426b is arranged on the bagging base 440, and the seal die guiding slide rail 426a is arranged on the seal head adjusting guide rail 426b in a sliding manner so as to adjust the interval between the heat sealer and the aluminum foil bag.
In one embodiment, the application further provides a biological freeze-dried microsphere assembly machine, which comprises the biological freeze-dried microsphere assembly device according to any one of the embodiments. In this embodiment, the biological lyophilized microsphere assembly device includes an assembly chassis, a chip loading assembly, a lyophilized microsphere sub-packaging assembly, and a lyophilized reagent chip bagging assembly; the chip feeding assembly comprises a chip transplanting rotary table, chip transplanting pieces and a plurality of blocking pieces, wherein the chip transplanting rotary table and the chip transplanting pieces are arranged on the assembly chassis, the blocking pieces are arranged on the chip transplanting rotary table, each blocking piece is used for limiting a plurality of freeze-dried reagent chips stacked and arranged, and the chip transplanting pieces are used for grabbing and moving the freeze-dried reagent chips; the freeze-dried microsphere split charging assembly comprises a chip feeding transmission belt and a plurality of biological freeze-dried microsphere feeding pieces, wherein the chip feeding transmission belt and the chip transplanting pieces are arranged on the assembly machine case, so that the chip transplanting pieces transplant the freeze-dried reagent chips onto the chip feeding transmission belt, and the biological freeze-dried microsphere feeding pieces are respectively distributed on two sides of the chip feeding transmission belt and are used for moving biological freeze-dried microspheres onto the freeze-dried reagent chips; the freeze-drying reagent chip bagging assembly comprises a chip material transferring conveying belt and a bagging sealing piece, wherein the chip material transferring conveying belt and the chip material feeding conveying belt are arranged on the assembly machine case in a corresponding mode, the chip material transferring conveying belt is used for conveying freeze-drying reagent chips output by the chip material feeding conveying belt, and the bagging end of the bagging sealing piece faces to the chip material transferring conveying belt and is used for bagging and sealing the freeze-drying reagent chips. A plurality of freeze-dried reagent chips are stored on the chip transplanting turntable, each freeze-dried reagent chip is placed on the chip feeding conveying belt respectively through the chip transplanting piece, so that quick feeding of the freeze-dried reagent chips is facilitated, a plurality of biological freeze-dried microsphere feeding pieces simultaneously place biological freeze-dried microspheres on the corresponding freeze-dried reagent chips, the feeding efficiency of the biological freeze-dried microspheres is improved, the freeze-dried reagent chips with the biological freeze-dried microspheres are sealed in bags by the bagging sealing piece, finished products of the biological freeze-dried microspheres are packaged quickly, and the assembly efficiency of the biological freeze-dried microspheres is effectively improved.
The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (9)
1. A biological lyophilization microsphere assembly device, comprising:
the chassis is assembled and the machine box is assembled,
the chip feeding assembly comprises a chip transplanting rotary table, chip transplanting pieces and a plurality of blocking pieces, wherein the chip transplanting rotary table and the chip transplanting pieces are arranged on the assembly chassis, the blocking pieces are arranged on the chip transplanting rotary table, each blocking piece is used for limiting a plurality of freeze-drying reagent chips stacked and arranged, and the chip transplanting pieces are used for grabbing and moving the freeze-drying reagent chips;
the freeze-dried microsphere split charging assembly comprises a chip feeding transmission belt and a plurality of biological freeze-dried microsphere feeding parts, wherein the chip feeding transmission belt and the chip transplanting parts are arranged on the assembly machine case, the chip transplanting parts are used for transplanting freeze-dried reagent chips onto the chip feeding transmission belt, and the biological freeze-dried microsphere feeding parts are respectively distributed on two sides of the chip feeding transmission belt and used for moving biological freeze-dried microspheres onto the freeze-dried reagent chips; the freeze-drying microsphere split charging assembly further comprises a cover piece attaching piece, wherein the cover piece attaching piece comprises a cover piece flying device, a cover piece coil stock and a cover piece transferring manipulator, the cover piece flying device and the cover piece transferring manipulator are both arranged on the assembly machine case, the cover piece coil stock is wound on a roller of the cover piece flying device, the cover piece flying device is further used for cutting a cover piece on the cover piece coil stock, and the cover piece transferring manipulator is used for transferring the cover piece onto a freeze-drying reagent chip on the chip feeding conveyor belt so as to seal biological freeze-drying microspheres on the freeze-drying reagent chip;
The freeze-drying reagent chip bagging assembly comprises a chip material transferring conveying belt and a bagging sealing piece, wherein the chip material transferring conveying belt and the chip material feeding conveying belt are arranged on the assembly machine case, the chip material transferring conveying belt is used for conveying freeze-drying reagent chips output by the chip material feeding conveying belt, and the bagging end of the bagging sealing piece faces to the chip material transferring conveying belt and is used for bagging and sealing the freeze-drying reagent chips.
2. The assembly device of claim 1, wherein each blocking member comprises a stacking block and at least two blocking rods, each stacking block is arranged on the chip transplanting turntable, the at least two blocking rods are arranged on one stacking block, a stacking area is formed between the at least two blocking rods, and the stacking area is used for placing a plurality of stacked freeze-dried reagent chips.
3. The assembly device of claim 2, wherein at least two of the retaining bars on each of the stacking blocks are disposed opposite each other.
4. The assembly device of biological freeze-dried microspheres according to claim 2, wherein the number of the material blocking rods is four, two of the material blocking rods are oppositely arranged, and the other two material blocking rods are oppositely arranged.
5. The assembly device of biological freeze-dried microspheres according to claim 1, wherein a plurality of the material blocking members are uniformly distributed on the chip transplanting turntable.
6. The assembly device of claim 5, wherein the distance between any two adjacent material blocking members is equal, and a plurality of material blocking members are circumferentially distributed on the edge of the chip transplanting turntable.
7. The biological freeze-drying microsphere assembly device according to claim 1, wherein the freeze-drying microsphere split charging component further comprises a first split transmission belt, a second split transmission belt and a silica gel cover split component, the first split transmission belt and the second split transmission belt are both arranged on the assembly chassis, the cover sheet attaching component further comprises a product taking manipulator arranged on the assembly chassis, the product taking manipulator is located between the first split transmission belt and the chip feeding transmission belt, the product taking manipulator is used for grabbing freeze-drying reagent chips on the chip feeding transmission belt onto the first split transmission belt, the silica gel cover split component comprises a silica gel cover vibration disc, a silica gel cover direct vibration track, a silica gel cover taking manipulator and a plurality of silica gel cover assembly manipulators, the silica gel cover vibration disc is used for arranging special-shaped silica gel covers, the silica gel cover direct vibration track, the silica gel cover manipulator and the silica gel cover assembly manipulators are all arranged on the assembly chassis, the product taking manipulator is located between the first split transmission belt and the chip feeding transmission belt, the silica gel cover vibration disc is used for grabbing the silica gel cover to the special-shaped carrier tape by the first split vibration disc, and the silica gel cover vibration disc is used for grabbing the special-shaped silica gel cover on the transmission belt.
8. The assembly device of claim 7, wherein the angular difference between two adjacent silicone cover assembly manipulators rotating the shaped silicone covers is equal.
9. A biological freeze-dried microsphere assembly machine comprising the biological freeze-dried microsphere assembly device according to any one of claims 1 to 8.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310553294.XA CN116374303B (en) | 2023-05-16 | 2023-05-16 | Biological freeze-drying microsphere assembly device and biological freeze-drying microsphere assembly machine |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310553294.XA CN116374303B (en) | 2023-05-16 | 2023-05-16 | Biological freeze-drying microsphere assembly device and biological freeze-drying microsphere assembly machine |
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| CN116374303A CN116374303A (en) | 2023-07-04 |
| CN116374303B true CN116374303B (en) | 2023-10-24 |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109367843A (en) * | 2018-09-19 | 2019-02-22 | 佛山阿尔法智能控制技术有限公司 | A kind of full-automatic horizontal vacuum packet wiring |
| CN112498867A (en) * | 2020-12-14 | 2021-03-16 | 苏州鑫富力劲自动化设备有限公司 | Automatic tray packaging machine |
| CN213863048U (en) * | 2020-11-25 | 2021-08-03 | 苏州爱锐邦智能科技有限公司 | Fast-assembling type labeling flying reach mechanism |
| CN114131315A (en) * | 2021-12-10 | 2022-03-04 | 浙江科博电器有限公司 | Assembling equipment for iron core and silica gel particles of electromagnetic valve |
| CN114180130A (en) * | 2021-12-15 | 2022-03-15 | 南京浦光生物科技有限公司 | Freeze-dried reagent microsphere integrated equipment of batch encapsulation |
| CN216233453U (en) * | 2021-09-27 | 2022-04-08 | 惠州市百思达精密机械有限公司 | Sticking mechanism for puff tube |
| CN115231066A (en) * | 2022-08-18 | 2022-10-25 | 江苏创源电子有限公司 | Automatic packaging machine |
-
2023
- 2023-05-16 CN CN202310553294.XA patent/CN116374303B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109367843A (en) * | 2018-09-19 | 2019-02-22 | 佛山阿尔法智能控制技术有限公司 | A kind of full-automatic horizontal vacuum packet wiring |
| CN213863048U (en) * | 2020-11-25 | 2021-08-03 | 苏州爱锐邦智能科技有限公司 | Fast-assembling type labeling flying reach mechanism |
| CN112498867A (en) * | 2020-12-14 | 2021-03-16 | 苏州鑫富力劲自动化设备有限公司 | Automatic tray packaging machine |
| CN216233453U (en) * | 2021-09-27 | 2022-04-08 | 惠州市百思达精密机械有限公司 | Sticking mechanism for puff tube |
| CN114131315A (en) * | 2021-12-10 | 2022-03-04 | 浙江科博电器有限公司 | Assembling equipment for iron core and silica gel particles of electromagnetic valve |
| CN114180130A (en) * | 2021-12-15 | 2022-03-15 | 南京浦光生物科技有限公司 | Freeze-dried reagent microsphere integrated equipment of batch encapsulation |
| CN115231066A (en) * | 2022-08-18 | 2022-10-25 | 江苏创源电子有限公司 | Automatic packaging machine |
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| CN116374303A (en) | 2023-07-04 |
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