CN116370549B - Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating hyperlipidemia and a preparation method thereof, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of rhizoma atractylodis, 10-15 parts of magnolia officinalis, 10-15 parts of radix scutellariae, 5-12 parts of papaya, 3-5 parts of medlar, 1-3 parts of semen astragali complanati, 1-3 parts of chrysanthemum and 0.5-2 parts of jujube. Animal experiments and clinical experiments prove that the prepared traditional Chinese medicine composition can obviously reduce the content of TG, TC, HDL-C and LDL-C in hyperlipidemia serum, and has obvious blood lipid reducing effect. The traditional Chinese medicine composition prepared by the invention has the advantages of convenient use, definite curative effect, stable and durable effect and important clinical value.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hyperlipidemia and a preparation method thereof.
Background
Hyperlipidemia, including hypercholesterolemia, hypertriglyceridemia and mixed hyperlipidemia, is an important risk factor for cerebral apoplexy, coronary heart disease, myocardial infarction and sudden cardiac death, and is mainly characterized by dizziness, headache, chest distress, chest pain, abdominal distention, obesity and the like. The occurrence and development of hyperlipidemia are related to various factors such as genetic inheritance, environmental factors (diet, nutrition, medicines and the like) and other factors (such as age, sex, season, drinking, smoking, mental stress, mood instability and the like), and research shows that the occurrence of hyperlipidemia is mostly caused by the comprehensive effect of various factors, while hyperlipidemia caused by a single factor is less, which also brings a certain difficulty to clinical treatment of hyperlipidemia.
At present, lipid-lowering western medicines are mainly used for preventing and treating clinically, but most of western medicines have great side effects and damage liver and kidney functions, such as simvastatin. The traditional Chinese patent medicines for reducing blood fat are also of various types and are full of eyes and various, but on one hand, the traditional Chinese medicine has slow blood fat reducing effect, and on the other hand, the traditional Chinese patent medicines for reducing blood fat have uncertain curative effect, so that people have worry about treating hyperlipidemia by using the traditional Chinese medicine, and meanwhile, the traditional Chinese medicine is limited in clinical use. In addition, the traditional Chinese medicine raw materials are directly used for decoction and administration, but the method has the problems of inconvenient use, difficult preservation and the like. Therefore, the novel traditional Chinese medicine for treating the hyperlipidemia, which has definite curative effect and convenient use, is very important for solving the existing technical problems.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating hyperlipidemia and a preparation method thereof, which are used for solving the problems existing in the prior art, realizing the purpose of reducing triglyceride, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in hyperlipidemia serum, and can be used for reducing hyperlipidemia.
In order to achieve the above object, the present invention provides the following solutions:
the invention provides a traditional Chinese medicine composition for treating hyperlipidemia, which comprises the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of rhizoma atractylodis, 10-15 parts of magnolia officinalis, 10-15 parts of radix scutellariae, 5-12 parts of papaya, 3-5 parts of medlar, 1-3 parts of semen astragali complanati, 1-3 parts of chrysanthemum and 0.5-2 parts of jujube.
Preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 15-20 parts of rhizoma atractylodis, 10-12 parts of magnolia officinalis, 10-12 parts of radix scutellariae, 8-12 parts of papaya, 3-4 parts of medlar, 2-3 parts of semen astragali complanati, 1-2 parts of chrysanthemum and 0.5-1 part of jujube.
Preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 18 parts of rhizoma atractylodis, 10 parts of magnolia officinalis, 11 parts of radix scutellariae, 10 parts of papaya, 3.5 parts of medlar, 2 parts of semen astragali complanati, 1.5 parts of chrysanthemum and 0.5 part of jujube.
Cang Zhu is pungent, bitter and warm in nature. Has the effects of eliminating dampness, strengthening spleen, dispelling wind, dispelling cold and improving eyesight. Is mainly used for treating damp obstruction of middle energizer, abdominal distention, diarrhea, edema, tinea pedis, rheumatalgia, wind-cold type common cold, night blindness, and eye dryness.
Magnolia officinalis is bitter and pungent in flavor and warm in nature. Dry dampness and remove phlegm, and lower qi and remove fullness. It is mainly used for treating damp stagnation, gastric fullness, vomiting and diarrhea, food stagnation, qi stagnation, abdominal distention, constipation, phlegm-fluid retention, asthma and cough.
Baical skullcap root, radix Scutellariae, has bitter and cold properties and has the effects of clearing heat and drying dampness, purging pathogenic fire and removing toxicity, stopping bleeding and preventing miscarriage. It is widely used for treating damp-heat fire toxin.
Papaya, sour taste and warm nature. Has the effects of relaxing muscles and tendons, activating collateral flow, regulating stomach function, and eliminating dampness. Is mainly used for treating damp arthralgia, contracture, soreness and pain of waist and knee joints, summer-heat damp vomiting and diarrhea, spasm pain of tendons, beriberi and edema.
Medlar, sweet and flat. Nourishing kidney, moistening lung, nourishing liver, improving eyesight. It is mainly indicated for deficiency of liver and kidney yin, soreness and weakness of waist and knees, dizziness, blurred vision, excessive tears, cough due to consumptive disease, diabetes and spermatorrhea.
Semen astragali Complanati is sweet in taste and warm in nature. Tonify kidney, strengthen yang, arrest spontaneous emission, reduce urination, nourish liver and improve vision. Is mainly used for treating lumbago due to kidney deficiency, spermatorrhea, premature ejaculation, enuresis, frequent urination, leukorrhagia, dizziness and dim eyesight.
Chrysanthemum is bitter and sweet in flavor and slightly cold in nature. Dispelling wind, clearing heat, calming liver, improving eyesight, and clearing away heat and toxic materials. Is mainly used for treating wind-heat type common cold, headache, dizziness, conjunctival congestion, eye pain, dim eyesight, sore, carbuncle and toxic swelling.
Jujube, sweet, warm. Tonify spleen and stomach, replenish qi and promote the production of body fluid, regulate nutrient and defensive qi and dispel toxin. Is mainly used for treating stomach deficiency, anorexia, spleen weakness, loose stool, deficiency of qi, blood and body fluid, incoordination between nutrient and defensive qi, palpitation. The woman is dysphoria.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating hyperlipidemia, which comprises the steps of weighing the traditional Chinese medicine raw materials according to the dosage of the traditional Chinese medicine composition, crushing rhizoma atractylodis, mangnolia officinalis, radix scutellariae, papaya and semen astragali complanati into powder of 0.1-1 mu m, and mixing medlar, chrysanthemum and Chinese date with the powder.
Preferably, the jujube is selected from dried jujube slices.
The invention also provides application of the traditional Chinese medicine composition in preparing medicines for treating hyperlipidemia.
The invention discloses the following technical effects:
the invention takes rhizoma atractylodis, magnolia officinalis and radix scutellariae as main medicines, mainly takes liver and kidney tonifying, blood fat reducing, digestion promoting and accumulation removing, mainly takes blood circulation activating and stasis removing, and is assisted with papaya, medlar and chrysanthemum for clearing damp, clearing heat and quenching thirst. Semen astragali Complanati and fructus Jujubae can tonify kidney essence, clear liver, moisten intestine and relieve constipation, thereby reducing hyperlipidemia. The invention also proves through animal experiments and clinical experiments that the prepared traditional Chinese medicine composition can obviously reduce the content of TG, TC, HDL-C and LDL-C in hyperlipidemia serum, and has obvious blood lipid reducing effect. The traditional Chinese medicine composition prepared by the invention has the advantages of convenient use, definite curative effect, stable and durable effect and important clinical value.
Detailed Description
Various exemplary embodiments of the invention will now be described in detail, which should not be considered as limiting the invention, but rather as more detailed descriptions of certain aspects, features and embodiments of the invention.
It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. In addition, for numerical ranges in this disclosure, it is understood that each intermediate value between the upper and lower limits of the ranges is also specifically disclosed. Every smaller range between any stated value or stated range, and any other stated value or intermediate value within the stated range, is also encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference for the purpose of disclosing and describing the methods and/or materials associated with the documents. In case of conflict with any incorporated document, the present specification will control.
It will be apparent to those skilled in the art that various modifications and variations can be made in the specific embodiments of the invention described herein without departing from the scope or spirit of the invention. Other embodiments will be apparent to those skilled in the art from consideration of the specification of the present invention. The specification and examples of the present invention are exemplary only.
As used herein, the terms "comprising," "including," "having," "containing," and the like are intended to be inclusive and mean an inclusion, but not limited to.
Example 1
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 10 parts of rhizoma atractylodis, 10 parts of magnolia officinalis, 10 parts of radix scutellariae, 5 parts of papaya, 3 parts of medlar, 1 part of semen astragali complanati, 1 part of chrysanthemum and 0.5 part of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 0.1 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Example 2
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 12 parts of rhizoma atractylodis, 11 parts of magnolia officinalis, 10 parts of radix scutellariae, 10 parts of papaya, 3 parts of medlar, 1.5 parts of semen astragali complanati, 1 part of chrysanthemum and 0.8 part of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 0.5 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Example 3
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 15 parts of rhizoma atractylodis, 10 parts of magnolia officinalis, 10 parts of radix scutellariae, 8 parts of papaya, 3 parts of medlar, 2 parts of semen astragali complanati, 1 part of chrysanthemum and 0.5 part of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 0.5 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Example 4
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 18 parts of rhizoma atractylodis, 11 parts of magnolia officinalis, 11 parts of scutellaria baicalensis, 9 parts of papaya, 3.5 parts of medlar, 2.5 parts of semen astragali complanati, 1.5 parts of chrysanthemum and 0.5 part of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 0.8 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Example 5
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 18 parts of rhizoma atractylodis, 10 parts of magnolia officinalis, 11 parts of radix scutellariae, 10 parts of papaya, 3.5 parts of medlar, 2 parts of semen astragali complanati, 1.5 parts of chrysanthemum and 0.5 part of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 0.5 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Example 6
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 20 parts of rhizoma atractylodis, 12 parts of magnolia officinalis, 12 parts of radix scutellariae, 12 parts of papaya, 4 parts of medlar, 3 parts of semen astragali complanati, 2 parts of chrysanthemum and 1 part of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 1 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Example 7
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 20 parts of rhizoma atractylodis, 15 parts of magnolia officinalis, 15 parts of radix scutellariae, 12 parts of papaya, 5 parts of medlar, 3 parts of semen astragali complanati, 3 parts of chrysanthemum and 2 parts of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 1 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Animal experiments were performed on the Chinese medicinal composition prepared in the above examples to verify the therapeutic effects thereof.
The formula of the high-fat feed comprises the following components: 90.1% of basic feed, 1.5% of cholesterol, 8.2% of lard and 0.2% of pig bile salt. Basal feed: 73.5% of corn, 20% of wheat bran, 5% of fish meal, 1% of cereal flour and 0.5% of salt.
120 clean-class C57 mice were selected, the quality of the mice was 15-25g, and after 1 week of the adaptive feeding of 120 mice, the mice were randomly divided into 12 groups of 10 animals each, and the model group, the positive group, the example 1 drug group-example 4 drug group, the example 5 low dose group, the example 5 medium dose group, the example 5 high dose group, the example 6 drug group, and the example 7 drug group were given high fat feeds in addition to the normal feed. The feed is fed for 14 days continuously for molding, and the feed is fed for 3 times per day, 2g each time, and normally drinks water.
After successful modeling of the hyperlipidemia of the mice, the gastric lavage is carried out once every morning and evening for 4 weeks continuously, and the dosage is given: simvastatin positive control was administered in 5mg/kg in the positive group, 1.5g/kg in the example 1 drug group-4 drug group, 5.3.0 g/kg in the example 7 drug group, and 6.0g/kg in the example 5 high dose group, 6.0g/kg in the example 5 drug group, and the normal group and the model group were administered with the same volume of physiological saline per mouse.
Mice were fasted overnight after 6 weeks, blood was collected from the orbital veins, and serum was centrifuged to determine Triglyceride (TG), total Cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C). Statistical data with SPSS software, experimental resultsThe comparison between groups is shown by t-test. The results are shown in Table 1.
TABLE 1
As can be seen from table 1 above, compared with the normal group, the traditional Chinese medicine composition prepared in examples 1-7 of the present application can reduce the content of TG, TC, HDL-C and LDL-C in serum, and especially the traditional Chinese medicine composition prepared in example 5 can significantly reduce the content of TG, TC, HDL-C and LDL-C, and the reduction effect is more remarkable with increasing dosage.
In order to further verify the therapeutic effect of the Chinese medicinal composition of the present invention, the present invention adopts the low dose group of example 5, the medium dose group of example 5, the high dose group of example 5, and the positive control group (simvastatin) for clinical experiments, and the experimental method is as follows:
1. case selection
80 patients meeting the hyperlipidemia criteria were randomly divided into 4 groups, of which 43 men, 37 women, the largest of the ages of 78 years, the smallest of 30 years, and the largest of 35-45 years. Occupation: the maximum number of cases is 15 years, the minimum number is half a year, and the average number is 6 years. Wherein, the degree of the disease among the groups is not significantly different in 25 cases of hypercholesterolemia, 35 cases of hypertriglyceridemia and 20 cases of mixed hyperlipidemia. All the patients are from the traditional Chinese medicine hospitals in Yunnan province, the ethical society of the traditional Chinese medicine hospitals in Yunnan province are informed of the consent of all the patients, and the consent of the patients is obtained.
2. Diagnostic criteria
Cholesterol (CT) >5.5mmol/L, triglyceride (TC) >1.69mmol/L, high Density Lipoprotein (HDL) < 1.03mmol/L, and low density lipoprotein (DC) >3.1mmol/L, which meet the diagnostic standards of hyperlipidemia of the teaching materials (fifth edition) of national higher medical institutions.
3. Therapeutic method
Example 5 low dose group: the traditional Chinese medicine composition prepared in the embodiment 5 of the invention is prepared into 50g of powder per bag, and 200mL of liquid is taken orally in the morning and evening each day.
Dose group in example 5: the traditional Chinese medicine composition prepared in the embodiment 5 of the invention is prepared into powder with 100g per bag, and 200mL of liquid is taken orally in the morning and evening each day.
Example 5 high dose group: the traditional Chinese medicine composition prepared in the embodiment 5 of the invention is prepared into 200g of powder per bag, and 200mL of liquid is taken orally in the morning and evening each day.
The positive control group was orally administered simvastatin once a day at night, 30mg each time.
All the patients in the above groups take the medicine for 1 month, and take the medicine for two courses of treatment, and blood lipid is checked for 1 time per month, and the statistical result is obtained after 2 months. During the treatment period, patients are instructed to take a reasonable diet, exercise properly, quit smoking and abstinence from alcohol.
The results are shown in Table 2 below:
TABLE 2
And (3) healing: the symptoms disappear, the blood lipid examination returns to normal, and the blood lipid is not increased after 2 times of rechecks;
the effect is shown: the symptoms disappear, the blood lipid examination returns to normal, and the blood lipid examination can rise again.
The method is effective: the symptoms are obviously relieved, the blood lipid examination is recovered to be normal within 2 months, and the blood lipid examination is often increased again.
Invalidation: the symptoms are not obviously reduced, and the blood lipid examination is not recovered to be normal within 2 months.
From the data, the number of cases of obvious effect and ineffective is close, probably due to the fact that each group of samples is smaller, but the total effective number of the traditional Chinese medicine composition prepared in the embodiment 5 of the invention is obviously more after two treatment courses of treatment, so that the treatment effect of the traditional Chinese medicine composition prepared in the embodiment is better than that of positive medicines.
The pathogenesis of hyperlipidemia is caused by the condition that the spleen and stomach are damaged due to the thick taste of the paste, or the spleen is damaged due to the overuse of the paste, the heart and spleen are damaged due to the fatigue, or the spleen is disturbed due to the qi damage caused by the long-time sitting and lying, the spleen is not healthy and transportation, the food cannot be essence, clear and turbid is not divided, dampness is accumulated into phlegm, blood is not smooth, phlegm and blood stasis are mutually accumulated, the spleen is blocked in the venation, the spleen is damaged due to the long-time damage to the kidney, and kidney essence deficiency is caused. So it is mainly used for invigorating qi, resolving phlegm, purging turbid urine, promoting blood circulation, removing blood stasis, and arresting spontaneous emission. The invention takes rhizoma atractylodis, magnolia officinalis and radix scutellariae as main medicines, mainly takes liver and kidney tonifying, blood fat reducing, digestion promoting and accumulation removing, mainly takes blood circulation activating and stasis removing, and is assisted with papaya, medlar and chrysanthemum for clearing damp, clearing heat and quenching thirst. Semen astragali Complanati and fructus Jujubae have effects of invigorating kidney essence, removing liver fire, loosening bowel to relieve constipation, and can be used for reducing hyperlipidemia, with definite therapeutic effect, stable and lasting effect, and important clinical value.
The above embodiments are only illustrative of the preferred embodiments of the present invention and are not intended to limit the scope of the present invention, and various modifications and improvements made by those skilled in the art to the technical solutions of the present invention should fall within the protection scope defined by the claims of the present invention without departing from the design spirit of the present invention.
Claims (4)
1. The traditional Chinese medicine composition for treating the hyperlipidemia is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 18 parts of rhizoma atractylodis, 10 parts of magnolia officinalis, 11 parts of radix scutellariae, 10 parts of papaya, 3.5 parts of medlar, 2 parts of semen astragali complanati, 1.5 parts of chrysanthemum and 0.5 part of jujube.
2. The method for preparing the Chinese medicinal composition for treating hyperlipidemia according to claim 1, wherein the Chinese medicinal composition is prepared by weighing the raw materials of the Chinese medicinal composition, pulverizing rhizoma Atractylodis, cortex Magnolia officinalis, radix Scutellariae, fructus Chaenomelis and semen astragali Complanati into 0.1-1 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder.
3. The method of claim 2, wherein the date is selected from dried date slices.
4. The use of the Chinese medicinal composition according to claim 1 for preparing a medicament for treating hyperlipidemia.
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