CN116370549B - Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof Download PDFInfo
- Publication number
- CN116370549B CN116370549B CN202310606934.9A CN202310606934A CN116370549B CN 116370549 B CN116370549 B CN 116370549B CN 202310606934 A CN202310606934 A CN 202310606934A CN 116370549 B CN116370549 B CN 116370549B
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- medicine composition
- hyperlipidemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 76
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 208000031226 Hyperlipidaemia Diseases 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 210000000582 semen Anatomy 0.000 claims abstract description 24
- 241001673966 Magnolia officinalis Species 0.000 claims abstract description 23
- 235000009467 Carica papaya Nutrition 0.000 claims abstract description 16
- 235000007516 Chrysanthemum Nutrition 0.000 claims abstract description 16
- 235000017784 Mespilus germanica Nutrition 0.000 claims abstract description 16
- 244000182216 Mimusops elengi Species 0.000 claims abstract description 16
- 235000000560 Mimusops elengi Nutrition 0.000 claims abstract description 16
- 235000007837 Vangueria infausta Nutrition 0.000 claims abstract description 16
- 244000126002 Ziziphus vulgaris Species 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 240000006432 Carica papaya Species 0.000 claims abstract 2
- 244000189548 Chrysanthemum x morifolium Species 0.000 claims abstract 2
- 239000000843 powder Substances 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 9
- 238000005303 weighing Methods 0.000 claims description 9
- 241000628997 Flos Species 0.000 claims description 8
- 238000010298 pulverizing process Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 210000004369 blood Anatomy 0.000 abstract description 20
- 239000008280 blood Substances 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 17
- 230000001603 reducing effect Effects 0.000 abstract description 11
- 150000002632 lipids Chemical class 0.000 abstract description 10
- 108010023302 HDL Cholesterol Proteins 0.000 abstract description 7
- 108010028554 LDL Cholesterol Proteins 0.000 abstract description 7
- 238000002474 experimental method Methods 0.000 abstract description 7
- 210000002966 serum Anatomy 0.000 abstract description 5
- 241001465754 Metazoa Species 0.000 abstract description 4
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 description 15
- 241000219173 Carica Species 0.000 description 14
- 241000723353 Chrysanthemum Species 0.000 description 14
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 10
- 210000003734 kidney Anatomy 0.000 description 10
- 210000000952 spleen Anatomy 0.000 description 10
- 210000004185 liver Anatomy 0.000 description 8
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- 230000004438 eyesight Effects 0.000 description 6
- 206010062717 Increased upper airway secretion Diseases 0.000 description 5
- 235000012000 cholesterol Nutrition 0.000 description 5
- 230000007812 deficiency Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 208000026435 phlegm Diseases 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 208000002173 dizziness Diseases 0.000 description 4
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 4
- 229960002855 simvastatin Drugs 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 3
- 208000019790 abdominal distention Diseases 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 206010008479 Chest Pain Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 108010010234 HDL Lipoproteins Proteins 0.000 description 2
- 102000015779 HDL Lipoproteins Human genes 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000035150 Hypercholesterolemia Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 206010041497 Spermatorrhoea Diseases 0.000 description 2
- 206010060755 Type V hyperlipidaemia Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 208000006575 hypertriglyceridemia Diseases 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 230000000171 quenching effect Effects 0.000 description 2
- 230000000391 smoking effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 229940126673 western medicines Drugs 0.000 description 2
- 208000004611 Abdominal Obesity Diseases 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010065941 Central obesity Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010947 Coordination abnormal Diseases 0.000 description 1
- 206010013774 Dry eye Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010015958 Eye pain Diseases 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 208000001140 Night Blindness Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 241000207929 Scutellaria Species 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 235000006545 Ziziphus mauritiana Nutrition 0.000 description 1
- 235000008529 Ziziphus vulgaris Nutrition 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000016290 incoordination Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 206010036596 premature ejaculation Diseases 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000019614 sour taste Nutrition 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for treating hyperlipidemia and a preparation method thereof, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of rhizoma atractylodis, 10-15 parts of magnolia officinalis, 10-15 parts of radix scutellariae, 5-12 parts of papaya, 3-5 parts of medlar, 1-3 parts of semen astragali complanati, 1-3 parts of chrysanthemum and 0.5-2 parts of jujube. Animal experiments and clinical experiments prove that the prepared traditional Chinese medicine composition can obviously reduce the content of TG, TC, HDL-C and LDL-C in hyperlipidemia serum, and has obvious blood lipid reducing effect. The traditional Chinese medicine composition prepared by the invention has the advantages of convenient use, definite curative effect, stable and durable effect and important clinical value.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hyperlipidemia and a preparation method thereof.
Background
Hyperlipidemia, including hypercholesterolemia, hypertriglyceridemia and mixed hyperlipidemia, is an important risk factor for cerebral apoplexy, coronary heart disease, myocardial infarction and sudden cardiac death, and is mainly characterized by dizziness, headache, chest distress, chest pain, abdominal distention, obesity and the like. The occurrence and development of hyperlipidemia are related to various factors such as genetic inheritance, environmental factors (diet, nutrition, medicines and the like) and other factors (such as age, sex, season, drinking, smoking, mental stress, mood instability and the like), and research shows that the occurrence of hyperlipidemia is mostly caused by the comprehensive effect of various factors, while hyperlipidemia caused by a single factor is less, which also brings a certain difficulty to clinical treatment of hyperlipidemia.
At present, lipid-lowering western medicines are mainly used for preventing and treating clinically, but most of western medicines have great side effects and damage liver and kidney functions, such as simvastatin. The traditional Chinese patent medicines for reducing blood fat are also of various types and are full of eyes and various, but on one hand, the traditional Chinese medicine has slow blood fat reducing effect, and on the other hand, the traditional Chinese patent medicines for reducing blood fat have uncertain curative effect, so that people have worry about treating hyperlipidemia by using the traditional Chinese medicine, and meanwhile, the traditional Chinese medicine is limited in clinical use. In addition, the traditional Chinese medicine raw materials are directly used for decoction and administration, but the method has the problems of inconvenient use, difficult preservation and the like. Therefore, the novel traditional Chinese medicine for treating the hyperlipidemia, which has definite curative effect and convenient use, is very important for solving the existing technical problems.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating hyperlipidemia and a preparation method thereof, which are used for solving the problems existing in the prior art, realizing the purpose of reducing triglyceride, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in hyperlipidemia serum, and can be used for reducing hyperlipidemia.
In order to achieve the above object, the present invention provides the following solutions:
the invention provides a traditional Chinese medicine composition for treating hyperlipidemia, which comprises the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of rhizoma atractylodis, 10-15 parts of magnolia officinalis, 10-15 parts of radix scutellariae, 5-12 parts of papaya, 3-5 parts of medlar, 1-3 parts of semen astragali complanati, 1-3 parts of chrysanthemum and 0.5-2 parts of jujube.
Preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 15-20 parts of rhizoma atractylodis, 10-12 parts of magnolia officinalis, 10-12 parts of radix scutellariae, 8-12 parts of papaya, 3-4 parts of medlar, 2-3 parts of semen astragali complanati, 1-2 parts of chrysanthemum and 0.5-1 part of jujube.
Preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 18 parts of rhizoma atractylodis, 10 parts of magnolia officinalis, 11 parts of radix scutellariae, 10 parts of papaya, 3.5 parts of medlar, 2 parts of semen astragali complanati, 1.5 parts of chrysanthemum and 0.5 part of jujube.
Cang Zhu is pungent, bitter and warm in nature. Has the effects of eliminating dampness, strengthening spleen, dispelling wind, dispelling cold and improving eyesight. Is mainly used for treating damp obstruction of middle energizer, abdominal distention, diarrhea, edema, tinea pedis, rheumatalgia, wind-cold type common cold, night blindness, and eye dryness.
Magnolia officinalis is bitter and pungent in flavor and warm in nature. Dry dampness and remove phlegm, and lower qi and remove fullness. It is mainly used for treating damp stagnation, gastric fullness, vomiting and diarrhea, food stagnation, qi stagnation, abdominal distention, constipation, phlegm-fluid retention, asthma and cough.
Baical skullcap root, radix Scutellariae, has bitter and cold properties and has the effects of clearing heat and drying dampness, purging pathogenic fire and removing toxicity, stopping bleeding and preventing miscarriage. It is widely used for treating damp-heat fire toxin.
Papaya, sour taste and warm nature. Has the effects of relaxing muscles and tendons, activating collateral flow, regulating stomach function, and eliminating dampness. Is mainly used for treating damp arthralgia, contracture, soreness and pain of waist and knee joints, summer-heat damp vomiting and diarrhea, spasm pain of tendons, beriberi and edema.
Medlar, sweet and flat. Nourishing kidney, moistening lung, nourishing liver, improving eyesight. It is mainly indicated for deficiency of liver and kidney yin, soreness and weakness of waist and knees, dizziness, blurred vision, excessive tears, cough due to consumptive disease, diabetes and spermatorrhea.
Semen astragali Complanati is sweet in taste and warm in nature. Tonify kidney, strengthen yang, arrest spontaneous emission, reduce urination, nourish liver and improve vision. Is mainly used for treating lumbago due to kidney deficiency, spermatorrhea, premature ejaculation, enuresis, frequent urination, leukorrhagia, dizziness and dim eyesight.
Chrysanthemum is bitter and sweet in flavor and slightly cold in nature. Dispelling wind, clearing heat, calming liver, improving eyesight, and clearing away heat and toxic materials. Is mainly used for treating wind-heat type common cold, headache, dizziness, conjunctival congestion, eye pain, dim eyesight, sore, carbuncle and toxic swelling.
Jujube, sweet, warm. Tonify spleen and stomach, replenish qi and promote the production of body fluid, regulate nutrient and defensive qi and dispel toxin. Is mainly used for treating stomach deficiency, anorexia, spleen weakness, loose stool, deficiency of qi, blood and body fluid, incoordination between nutrient and defensive qi, palpitation. The woman is dysphoria.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating hyperlipidemia, which comprises the steps of weighing the traditional Chinese medicine raw materials according to the dosage of the traditional Chinese medicine composition, crushing rhizoma atractylodis, mangnolia officinalis, radix scutellariae, papaya and semen astragali complanati into powder of 0.1-1 mu m, and mixing medlar, chrysanthemum and Chinese date with the powder.
Preferably, the jujube is selected from dried jujube slices.
The invention also provides application of the traditional Chinese medicine composition in preparing medicines for treating hyperlipidemia.
The invention discloses the following technical effects:
the invention takes rhizoma atractylodis, magnolia officinalis and radix scutellariae as main medicines, mainly takes liver and kidney tonifying, blood fat reducing, digestion promoting and accumulation removing, mainly takes blood circulation activating and stasis removing, and is assisted with papaya, medlar and chrysanthemum for clearing damp, clearing heat and quenching thirst. Semen astragali Complanati and fructus Jujubae can tonify kidney essence, clear liver, moisten intestine and relieve constipation, thereby reducing hyperlipidemia. The invention also proves through animal experiments and clinical experiments that the prepared traditional Chinese medicine composition can obviously reduce the content of TG, TC, HDL-C and LDL-C in hyperlipidemia serum, and has obvious blood lipid reducing effect. The traditional Chinese medicine composition prepared by the invention has the advantages of convenient use, definite curative effect, stable and durable effect and important clinical value.
Detailed Description
Various exemplary embodiments of the invention will now be described in detail, which should not be considered as limiting the invention, but rather as more detailed descriptions of certain aspects, features and embodiments of the invention.
It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. In addition, for numerical ranges in this disclosure, it is understood that each intermediate value between the upper and lower limits of the ranges is also specifically disclosed. Every smaller range between any stated value or stated range, and any other stated value or intermediate value within the stated range, is also encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference for the purpose of disclosing and describing the methods and/or materials associated with the documents. In case of conflict with any incorporated document, the present specification will control.
It will be apparent to those skilled in the art that various modifications and variations can be made in the specific embodiments of the invention described herein without departing from the scope or spirit of the invention. Other embodiments will be apparent to those skilled in the art from consideration of the specification of the present invention. The specification and examples of the present invention are exemplary only.
As used herein, the terms "comprising," "including," "having," "containing," and the like are intended to be inclusive and mean an inclusion, but not limited to.
Example 1
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 10 parts of rhizoma atractylodis, 10 parts of magnolia officinalis, 10 parts of radix scutellariae, 5 parts of papaya, 3 parts of medlar, 1 part of semen astragali complanati, 1 part of chrysanthemum and 0.5 part of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 0.1 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Example 2
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 12 parts of rhizoma atractylodis, 11 parts of magnolia officinalis, 10 parts of radix scutellariae, 10 parts of papaya, 3 parts of medlar, 1.5 parts of semen astragali complanati, 1 part of chrysanthemum and 0.8 part of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 0.5 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Example 3
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 15 parts of rhizoma atractylodis, 10 parts of magnolia officinalis, 10 parts of radix scutellariae, 8 parts of papaya, 3 parts of medlar, 2 parts of semen astragali complanati, 1 part of chrysanthemum and 0.5 part of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 0.5 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Example 4
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 18 parts of rhizoma atractylodis, 11 parts of magnolia officinalis, 11 parts of scutellaria baicalensis, 9 parts of papaya, 3.5 parts of medlar, 2.5 parts of semen astragali complanati, 1.5 parts of chrysanthemum and 0.5 part of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 0.8 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Example 5
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 18 parts of rhizoma atractylodis, 10 parts of magnolia officinalis, 11 parts of radix scutellariae, 10 parts of papaya, 3.5 parts of medlar, 2 parts of semen astragali complanati, 1.5 parts of chrysanthemum and 0.5 part of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 0.5 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Example 6
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 20 parts of rhizoma atractylodis, 12 parts of magnolia officinalis, 12 parts of radix scutellariae, 12 parts of papaya, 4 parts of medlar, 3 parts of semen astragali complanati, 2 parts of chrysanthemum and 1 part of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 1 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Example 7
A traditional Chinese medicine composition for treating hyperlipidemia comprises the following traditional Chinese medicine raw materials in parts by weight: 20 parts of rhizoma atractylodis, 15 parts of magnolia officinalis, 15 parts of radix scutellariae, 12 parts of papaya, 5 parts of medlar, 3 parts of semen astragali complanati, 3 parts of chrysanthemum and 2 parts of jujube.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing rhizoma Atractylodis, cortex Magnolia officinalis, scutellariae radix, fructus Chaenomelis and semen astragali Complanati in the above formula, pulverizing into 1 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder. Wherein the fructus Jujubae is preferably dry fructus Jujubae.
Animal experiments were performed on the Chinese medicinal composition prepared in the above examples to verify the therapeutic effects thereof.
The formula of the high-fat feed comprises the following components: 90.1% of basic feed, 1.5% of cholesterol, 8.2% of lard and 0.2% of pig bile salt. Basal feed: 73.5% of corn, 20% of wheat bran, 5% of fish meal, 1% of cereal flour and 0.5% of salt.
120 clean-class C57 mice were selected, the quality of the mice was 15-25g, and after 1 week of the adaptive feeding of 120 mice, the mice were randomly divided into 12 groups of 10 animals each, and the model group, the positive group, the example 1 drug group-example 4 drug group, the example 5 low dose group, the example 5 medium dose group, the example 5 high dose group, the example 6 drug group, and the example 7 drug group were given high fat feeds in addition to the normal feed. The feed is fed for 14 days continuously for molding, and the feed is fed for 3 times per day, 2g each time, and normally drinks water.
After successful modeling of the hyperlipidemia of the mice, the gastric lavage is carried out once every morning and evening for 4 weeks continuously, and the dosage is given: simvastatin positive control was administered in 5mg/kg in the positive group, 1.5g/kg in the example 1 drug group-4 drug group, 5.3.0 g/kg in the example 7 drug group, and 6.0g/kg in the example 5 high dose group, 6.0g/kg in the example 5 drug group, and the normal group and the model group were administered with the same volume of physiological saline per mouse.
Mice were fasted overnight after 6 weeks, blood was collected from the orbital veins, and serum was centrifuged to determine Triglyceride (TG), total Cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C). Statistical data with SPSS software, experimental resultsThe comparison between groups is shown by t-test. The results are shown in Table 1.
TABLE 1
As can be seen from table 1 above, compared with the normal group, the traditional Chinese medicine composition prepared in examples 1-7 of the present application can reduce the content of TG, TC, HDL-C and LDL-C in serum, and especially the traditional Chinese medicine composition prepared in example 5 can significantly reduce the content of TG, TC, HDL-C and LDL-C, and the reduction effect is more remarkable with increasing dosage.
In order to further verify the therapeutic effect of the Chinese medicinal composition of the present invention, the present invention adopts the low dose group of example 5, the medium dose group of example 5, the high dose group of example 5, and the positive control group (simvastatin) for clinical experiments, and the experimental method is as follows:
1. case selection
80 patients meeting the hyperlipidemia criteria were randomly divided into 4 groups, of which 43 men, 37 women, the largest of the ages of 78 years, the smallest of 30 years, and the largest of 35-45 years. Occupation: the maximum number of cases is 15 years, the minimum number is half a year, and the average number is 6 years. Wherein, the degree of the disease among the groups is not significantly different in 25 cases of hypercholesterolemia, 35 cases of hypertriglyceridemia and 20 cases of mixed hyperlipidemia. All the patients are from the traditional Chinese medicine hospitals in Yunnan province, the ethical society of the traditional Chinese medicine hospitals in Yunnan province are informed of the consent of all the patients, and the consent of the patients is obtained.
2. Diagnostic criteria
Cholesterol (CT) >5.5mmol/L, triglyceride (TC) >1.69mmol/L, high Density Lipoprotein (HDL) < 1.03mmol/L, and low density lipoprotein (DC) >3.1mmol/L, which meet the diagnostic standards of hyperlipidemia of the teaching materials (fifth edition) of national higher medical institutions.
3. Therapeutic method
Example 5 low dose group: the traditional Chinese medicine composition prepared in the embodiment 5 of the invention is prepared into 50g of powder per bag, and 200mL of liquid is taken orally in the morning and evening each day.
Dose group in example 5: the traditional Chinese medicine composition prepared in the embodiment 5 of the invention is prepared into powder with 100g per bag, and 200mL of liquid is taken orally in the morning and evening each day.
Example 5 high dose group: the traditional Chinese medicine composition prepared in the embodiment 5 of the invention is prepared into 200g of powder per bag, and 200mL of liquid is taken orally in the morning and evening each day.
The positive control group was orally administered simvastatin once a day at night, 30mg each time.
All the patients in the above groups take the medicine for 1 month, and take the medicine for two courses of treatment, and blood lipid is checked for 1 time per month, and the statistical result is obtained after 2 months. During the treatment period, patients are instructed to take a reasonable diet, exercise properly, quit smoking and abstinence from alcohol.
The results are shown in Table 2 below:
TABLE 2
And (3) healing: the symptoms disappear, the blood lipid examination returns to normal, and the blood lipid is not increased after 2 times of rechecks;
the effect is shown: the symptoms disappear, the blood lipid examination returns to normal, and the blood lipid examination can rise again.
The method is effective: the symptoms are obviously relieved, the blood lipid examination is recovered to be normal within 2 months, and the blood lipid examination is often increased again.
Invalidation: the symptoms are not obviously reduced, and the blood lipid examination is not recovered to be normal within 2 months.
From the data, the number of cases of obvious effect and ineffective is close, probably due to the fact that each group of samples is smaller, but the total effective number of the traditional Chinese medicine composition prepared in the embodiment 5 of the invention is obviously more after two treatment courses of treatment, so that the treatment effect of the traditional Chinese medicine composition prepared in the embodiment is better than that of positive medicines.
The pathogenesis of hyperlipidemia is caused by the condition that the spleen and stomach are damaged due to the thick taste of the paste, or the spleen is damaged due to the overuse of the paste, the heart and spleen are damaged due to the fatigue, or the spleen is disturbed due to the qi damage caused by the long-time sitting and lying, the spleen is not healthy and transportation, the food cannot be essence, clear and turbid is not divided, dampness is accumulated into phlegm, blood is not smooth, phlegm and blood stasis are mutually accumulated, the spleen is blocked in the venation, the spleen is damaged due to the long-time damage to the kidney, and kidney essence deficiency is caused. So it is mainly used for invigorating qi, resolving phlegm, purging turbid urine, promoting blood circulation, removing blood stasis, and arresting spontaneous emission. The invention takes rhizoma atractylodis, magnolia officinalis and radix scutellariae as main medicines, mainly takes liver and kidney tonifying, blood fat reducing, digestion promoting and accumulation removing, mainly takes blood circulation activating and stasis removing, and is assisted with papaya, medlar and chrysanthemum for clearing damp, clearing heat and quenching thirst. Semen astragali Complanati and fructus Jujubae have effects of invigorating kidney essence, removing liver fire, loosening bowel to relieve constipation, and can be used for reducing hyperlipidemia, with definite therapeutic effect, stable and lasting effect, and important clinical value.
The above embodiments are only illustrative of the preferred embodiments of the present invention and are not intended to limit the scope of the present invention, and various modifications and improvements made by those skilled in the art to the technical solutions of the present invention should fall within the protection scope defined by the claims of the present invention without departing from the design spirit of the present invention.
Claims (4)
1. The traditional Chinese medicine composition for treating the hyperlipidemia is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 18 parts of rhizoma atractylodis, 10 parts of magnolia officinalis, 11 parts of radix scutellariae, 10 parts of papaya, 3.5 parts of medlar, 2 parts of semen astragali complanati, 1.5 parts of chrysanthemum and 0.5 part of jujube.
2. The method for preparing the Chinese medicinal composition for treating hyperlipidemia according to claim 1, wherein the Chinese medicinal composition is prepared by weighing the raw materials of the Chinese medicinal composition, pulverizing rhizoma Atractylodis, cortex Magnolia officinalis, radix Scutellariae, fructus Chaenomelis and semen astragali Complanati into 0.1-1 μm powder, and mixing fructus Lycii, flos Chrysanthemi and fructus Jujubae with the powder.
3. The method of claim 2, wherein the date is selected from dried date slices.
4. The use of the Chinese medicinal composition according to claim 1 for preparing a medicament for treating hyperlipidemia.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202310606934.9A CN116370549B (en) | 2023-05-26 | 2023-05-26 | Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202310606934.9A CN116370549B (en) | 2023-05-26 | 2023-05-26 | Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN116370549A CN116370549A (en) | 2023-07-04 |
CN116370549B true CN116370549B (en) | 2024-03-08 |
Family
ID=86969697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202310606934.9A Active CN116370549B (en) | 2023-05-26 | 2023-05-26 | Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN116370549B (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114306424A (en) * | 2022-01-18 | 2022-04-12 | 上海市中医医院 | Traditional Chinese medicine composition for treating obesity and preparation method and application thereof |
-
2023
- 2023-05-26 CN CN202310606934.9A patent/CN116370549B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114306424A (en) * | 2022-01-18 | 2022-04-12 | 上海市中医医院 | Traditional Chinese medicine composition for treating obesity and preparation method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
CN116370549A (en) | 2023-07-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101787432B1 (en) | Method for manufacturing oriental medicine composition which improves menorrhagia and dysmenorrhea comprising fermented velvet antler and yeast hydrolysate | |
CN102048933A (en) | Chinese medicinal composition for treating infantile diarrhea and preparation method thereof | |
CN104187172B (en) | Functional feed for treating enterogastritis diseases of turtles and preparation method of functional feed | |
CN104351573A (en) | Mixed feed for treating cow hypogalactia and preparation method thereof | |
CN105166544A (en) | Pig mixed feed and preparation method thereof | |
CN102205108B (en) | Traditional Chinese medicine preparation for treating gastric ulcer and preparation method thereof | |
CN105076894A (en) | Cow mixed feed and preparation method thereof | |
CN104855734A (en) | Assisted dog food for fat dogs and preparation method of assisted dog food | |
US20190192598A1 (en) | Chinese Herbal Oral Paste for Conditioning Phlegm-dampness Constitution and Processing Method thereof | |
KR100742502B1 (en) | Composition of a traditional oriental medicine for an atopy treatment | |
CN108208456A (en) | A kind of feed addictive for improving laying rate of laying hen and preparation method thereof | |
CN106177432A (en) | A kind of health composition comprising leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati | |
CN103920140B (en) | A kind of people is with blood sugar lowering Weight-reducing and lipid-lowering compound preparation | |
CN104001045A (en) | Drug for treating dog pneumonia and preparation method thereof | |
CN103230486A (en) | Traditional Chinese medicine composition, preparation method thereof, and application thereof in preparing medicines used for treating fatty liver | |
CN116370549B (en) | Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof | |
CN103239667B (en) | Chinese traditional medicine for treating foot-and-mouth disease of domestic animals | |
TW202330006A (en) | Composition for preventing, improving or alleviating symptoms relating to qi deficiency and/or blood deficiency | |
CN107714933B (en) | Traditional Chinese medicine for losing weight, eliminating dampness and tonifying spleen and preparation method thereof | |
CN105533148A (en) | Cattle mixed feed and preparation method thereof | |
CN104206597B (en) | A kind of schisandra health care tea alleviating YIN-deficiency of the lung and kidney symptom and preparation method thereof | |
CN114712466B (en) | Medicine with weight-reducing and beautifying effects and preparation method thereof | |
CN103239673B (en) | Traditional Chinese medicine composition for preventing and curing sudden death syndrome of cow | |
CN102579713B (en) | Traditional Chinese medicine for treating children obesity and preparation method | |
CN103610991B (en) | Medicine being used for the treatment of swine gastric ulcer and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |