CN116348135A - 基于重组痘病毒的抗SARS-CoV-2病毒疫苗 - Google Patents
基于重组痘病毒的抗SARS-CoV-2病毒疫苗 Download PDFInfo
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- CN116348135A CN116348135A CN202180027983.6A CN202180027983A CN116348135A CN 116348135 A CN116348135 A CN 116348135A CN 202180027983 A CN202180027983 A CN 202180027983A CN 116348135 A CN116348135 A CN 116348135A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20071—Demonstrated in vivo effect
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
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- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
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- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
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- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062981997P | 2020-02-26 | 2020-02-26 | |
| US62/981,997 | 2020-02-26 | ||
| US202063114514P | 2020-11-16 | 2020-11-16 | |
| US63/114,514 | 2020-11-16 | ||
| PCT/US2021/020119 WO2021174142A1 (en) | 2020-02-26 | 2021-02-26 | Recombinant poxvirus based vaccine against sars-cov-2 virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116348135A true CN116348135A (zh) | 2023-06-27 |
Family
ID=75267580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180027983.6A Pending CN116348135A (zh) | 2020-02-26 | 2021-02-26 | 基于重组痘病毒的抗SARS-CoV-2病毒疫苗 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210260182A1 (https=) |
| EP (1) | EP4110386A1 (https=) |
| JP (1) | JP2023515582A (https=) |
| KR (1) | KR20220165731A (https=) |
| CN (1) | CN116348135A (https=) |
| AU (1) | AU2021226592A1 (https=) |
| BR (1) | BR112022016992A2 (https=) |
| CA (1) | CA3173996A1 (https=) |
| IL (1) | IL295925A (https=) |
| MX (1) | MX2022010588A (https=) |
| TW (1) | TWI902763B (https=) |
| WO (1) | WO2021174142A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4103231A4 (en) * | 2020-02-14 | 2024-03-27 | Geovax, Inc. | VACCINES AND THEIR USES TO INDUCE AN IMMUNE RESPONSE AGAINST SARS-COV2 |
| US12558415B2 (en) * | 2020-04-14 | 2026-02-24 | The Regents Of The University Of California | Broad-spectrum multi-antigen pan-coronavirus vaccine |
| EP4153228A4 (en) * | 2020-05-17 | 2024-07-10 | City of Hope | CORONAVIRUS VACCINES BASED ON SYNTHETIC MODIFIED ANKARA VACCINE (SMVA) VIRUS |
| US20230295655A1 (en) * | 2020-07-31 | 2023-09-21 | Tokyo Metropolitan Institute Of Medical Science | Recombinant vaccinia virus |
| TW202334434A (zh) * | 2021-07-21 | 2023-09-01 | 中央研究院 | 對抗嚴重急性呼吸道症候群冠狀病毒2型之基於痘病毒的疫苗及使用該疫苗的方法 |
| CN113621076A (zh) * | 2021-08-31 | 2021-11-09 | 南华大学 | 一种针对新冠病毒变异毒株Delta的融合蛋白、喷鼻式疫苗及其制备方法和应用 |
| US20250064919A1 (en) * | 2022-01-06 | 2025-02-27 | Board Of Regents, The University Of Texas System | A SARS-COV-2 Human Parainfluenza Virus Type 3-Vectored Vaccine |
| WO2023168286A1 (en) * | 2022-03-01 | 2023-09-07 | Tonix Pharmaceuticals Holding Corp. | Recombinant poxvirus based vaccine against the omicron strain of sars-cov-2 virus and variants thereof |
| EP4316514A1 (en) * | 2022-08-03 | 2024-02-07 | Consejo Superior de Investigaciones Científicas (CSIC) | Mva-based vectors and their use as vaccine against sars-cov-2 |
| GB2624391A (en) * | 2022-11-15 | 2024-05-22 | Univ Cape Town | Recombinant LSDV vectored bovine coronavirus antigen constructs |
Citations (10)
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|---|---|---|---|---|
| WO2004091524A2 (en) * | 2003-04-14 | 2004-10-28 | Acambis Inc. | Respiratory virus vaccines |
| WO2005028634A2 (en) * | 2003-09-18 | 2005-03-31 | Emory University | Improved mva vaccines |
| WO2005081716A2 (en) * | 2003-11-24 | 2005-09-09 | The Johns Hopkins University | DNA VACCINES TARGETING ANTIGENS OF THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS (SARS-CoV) |
| WO2005103259A1 (en) * | 2004-04-26 | 2005-11-03 | University Health Network | Sars-cov nucleocapsid protein epitopes and uses thereof |
| WO2006038742A1 (ja) * | 2004-10-08 | 2006-04-13 | Post Genome Institute Co., Ltd. | 組み換えウイルスおよびその用途 |
| CN1852921A (zh) * | 2003-07-21 | 2006-10-25 | 美国政府卫生及公众服务部国家卫生协会 | Sars冠状病毒刺突糖蛋白的可溶性片段 |
| CN101020055A (zh) * | 2006-02-16 | 2007-08-22 | 中国疾病预防控制中心性病艾滋病预防控制中心 | 基于复制型痘苗病毒载体的sars疫苗 |
| CN101022827A (zh) * | 2004-06-30 | 2007-08-22 | 魁北克益得生物医学公司 | 用于治疗冠状病毒感染的疫苗组合物 |
| US20130195912A1 (en) * | 2010-04-16 | 2013-08-01 | Isis Inovation Limited | Poxvirus Expression System |
| EP3045181A1 (en) * | 2015-01-19 | 2016-07-20 | Ludwig-Maximilians-Universität München | A novel vaccine against the middle east respiratory syndrome coronavirus (MERS-CoV) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6004777A (en) * | 1997-03-12 | 1999-12-21 | Virogenetics Corporation | Vectors having enhanced expression, and methods of making and uses thereof |
| US8541003B2 (en) * | 2003-06-20 | 2013-09-24 | Protein Sciences Corporation | Vectors expressing SARS immunogens, compositions containing such vectors or expression products thereof, methods and assays for making and using |
| JPWO2006022215A1 (ja) * | 2004-08-23 | 2008-05-08 | 財団法人ヒューマンサイエンス振興財団 | SARS−コロナウイルスタンパク質をコードするDNAを保有する組換えワクチニアウイルスDIs株、およびその利用 |
| WO2017047089A1 (en) * | 2015-09-16 | 2017-03-23 | Shin Nippon Biomedical Laboratories, Ltd. | Vaccine compositions |
| JP2019535311A (ja) | 2016-11-02 | 2019-12-12 | デイビッド エバンス, | 合成キメラポックスウイルス |
| EP3788142A4 (en) | 2018-05-02 | 2022-04-27 | Tonix Pharma Holdings Limited | SYNTHETIC CHIMERIC VACCINE VIRUS |
| US10906944B2 (en) * | 2020-06-29 | 2021-02-02 | The Scripps Research Institute | Stabilized coronavirus spike (S) protein immunogens and related vaccines |
-
2021
- 2021-02-26 KR KR1020227033014A patent/KR20220165731A/ko active Pending
- 2021-02-26 CA CA3173996A patent/CA3173996A1/en active Pending
- 2021-02-26 US US17/187,678 patent/US20210260182A1/en active Pending
- 2021-02-26 BR BR112022016992A patent/BR112022016992A2/pt unknown
- 2021-02-26 EP EP21715007.7A patent/EP4110386A1/en active Pending
- 2021-02-26 TW TW110107179A patent/TWI902763B/zh active
- 2021-02-26 JP JP2022551297A patent/JP2023515582A/ja not_active Withdrawn
- 2021-02-26 AU AU2021226592A patent/AU2021226592A1/en active Pending
- 2021-02-26 MX MX2022010588A patent/MX2022010588A/es unknown
- 2021-02-26 IL IL295925A patent/IL295925A/en unknown
- 2021-02-26 CN CN202180027983.6A patent/CN116348135A/zh active Pending
- 2021-02-26 WO PCT/US2021/020119 patent/WO2021174142A1/en not_active Ceased
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004091524A2 (en) * | 2003-04-14 | 2004-10-28 | Acambis Inc. | Respiratory virus vaccines |
| CN1852921A (zh) * | 2003-07-21 | 2006-10-25 | 美国政府卫生及公众服务部国家卫生协会 | Sars冠状病毒刺突糖蛋白的可溶性片段 |
| WO2005028634A2 (en) * | 2003-09-18 | 2005-03-31 | Emory University | Improved mva vaccines |
| WO2005081716A2 (en) * | 2003-11-24 | 2005-09-09 | The Johns Hopkins University | DNA VACCINES TARGETING ANTIGENS OF THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS (SARS-CoV) |
| WO2005103259A1 (en) * | 2004-04-26 | 2005-11-03 | University Health Network | Sars-cov nucleocapsid protein epitopes and uses thereof |
| CN101022827A (zh) * | 2004-06-30 | 2007-08-22 | 魁北克益得生物医学公司 | 用于治疗冠状病毒感染的疫苗组合物 |
| WO2006038742A1 (ja) * | 2004-10-08 | 2006-04-13 | Post Genome Institute Co., Ltd. | 組み換えウイルスおよびその用途 |
| CN101020055A (zh) * | 2006-02-16 | 2007-08-22 | 中国疾病预防控制中心性病艾滋病预防控制中心 | 基于复制型痘苗病毒载体的sars疫苗 |
| US20130195912A1 (en) * | 2010-04-16 | 2013-08-01 | Isis Inovation Limited | Poxvirus Expression System |
| EP3045181A1 (en) * | 2015-01-19 | 2016-07-20 | Ludwig-Maximilians-Universität München | A novel vaccine against the middle east respiratory syndrome coronavirus (MERS-CoV) |
Non-Patent Citations (1)
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| ANJEANETTE ROBERTS等: ""A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice"", PLOS PATHOG, vol. 3, no. 1, 14 January 2005 (2005-01-14), pages 0023 - 0034 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2022010588A (es) | 2023-02-09 |
| KR20220165731A (ko) | 2022-12-15 |
| WO2021174142A1 (en) | 2021-09-02 |
| JP2023515582A (ja) | 2023-04-13 |
| CA3173996A1 (en) | 2021-09-02 |
| AU2021226592A1 (en) | 2022-09-22 |
| BR112022016992A2 (pt) | 2022-10-25 |
| IL295925A (en) | 2022-10-01 |
| TWI902763B (zh) | 2025-11-01 |
| EP4110386A1 (en) | 2023-01-04 |
| US20210260182A1 (en) | 2021-08-26 |
| TW202146428A (zh) | 2021-12-16 |
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