CN116327617A - Whitening and moisturizing essence composition and preparation method thereof - Google Patents
Whitening and moisturizing essence composition and preparation method thereof Download PDFInfo
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- CN116327617A CN116327617A CN202310381023.0A CN202310381023A CN116327617A CN 116327617 A CN116327617 A CN 116327617A CN 202310381023 A CN202310381023 A CN 202310381023A CN 116327617 A CN116327617 A CN 116327617A
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 44
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 37
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 48
- 239000002994 raw material Substances 0.000 claims abstract description 42
- CSHZYWUPJWVTMQ-UHFFFAOYSA-N 4-n-Butylresorcinol Chemical compound CCCCC1=CC=C(O)C=C1O CSHZYWUPJWVTMQ-UHFFFAOYSA-N 0.000 claims abstract description 31
- LBQIJVLKGVZRIW-ZDUSSCGKSA-N glabridin Chemical compound C1([C@H]2CC3=CC=C4OC(C=CC4=C3OC2)(C)C)=CC=C(O)C=C1O LBQIJVLKGVZRIW-ZDUSSCGKSA-N 0.000 claims abstract description 31
- 229940093767 glabridin Drugs 0.000 claims abstract description 31
- PMPYOYXFIHXBJI-ZDUSSCGKSA-N glabridin Natural products C1([C@H]2CC=3C=CC4=C(C=3OC2)CCC(O4)(C)C)=CC=C(O)C=C1O PMPYOYXFIHXBJI-ZDUSSCGKSA-N 0.000 claims abstract description 31
- LBQIJVLKGVZRIW-UHFFFAOYSA-N glabridine Natural products C1OC2=C3C=CC(C)(C)OC3=CC=C2CC1C1=CC=C(O)C=C1O LBQIJVLKGVZRIW-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000012498 ultrapure water Substances 0.000 claims abstract description 26
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 25
- 241000219304 Portulacaceae Species 0.000 claims abstract description 25
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000003381 stabilizer Substances 0.000 claims abstract description 24
- 230000008719 thickening Effects 0.000 claims abstract description 24
- YPUZOECTETYPRF-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrimidine-2-carboxylic acid Chemical compound OC(=O)C1NCC=CN1 YPUZOECTETYPRF-UHFFFAOYSA-N 0.000 claims abstract description 19
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 claims abstract description 19
- 108010087806 Carnosine Proteins 0.000 claims abstract description 19
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 19
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 19
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 19
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 19
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 claims abstract description 19
- 229940044199 carnosine Drugs 0.000 claims abstract description 19
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 19
- 229940101267 panthenol Drugs 0.000 claims abstract description 19
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 19
- 239000011619 pantothenol Substances 0.000 claims abstract description 19
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 19
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 19
- 239000000022 bacteriostatic agent Substances 0.000 claims abstract description 9
- -1 acrylic ester Chemical class 0.000 claims description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 8
- 229920000858 Cyclodextrin Polymers 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 230000001804 emulsifying effect Effects 0.000 claims description 7
- 239000004744 fabric Substances 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 6
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 5
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 5
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 5
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 claims description 5
- 229920006037 cross link polymer Polymers 0.000 claims description 5
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 5
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 5
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 5
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 claims description 5
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 5
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 5
- 229960005323 phenoxyethanol Drugs 0.000 claims description 5
- 150000003904 phospholipids Chemical class 0.000 claims description 5
- 229940064064 purslane extract Drugs 0.000 claims description 5
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims 4
- 230000000694 effects Effects 0.000 abstract description 14
- 239000004615 ingredient Substances 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 abstract 1
- 230000035764 nutrition Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 5
- 239000013543 active substance Substances 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 229940101578 microlipid Drugs 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 206010040914 Skin reaction Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 238000005282 brightening Methods 0.000 description 3
- 230000035483 skin reaction Effects 0.000 description 3
- 231100000430 skin reaction Toxicity 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- FHKPLLOSJHHKNU-INIZCTEOSA-N [(3S)-3-[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]oxypyrrolidin-1-yl]-(oxan-4-yl)methanone Chemical compound C(C)N1N=CC(=C1C)C=1N(C2=NC=NC(=C2N=1)O[C@@H]1CN(CC1)C(=O)C1CCOCC1)C FHKPLLOSJHHKNU-INIZCTEOSA-N 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000002344 surface layer Substances 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a whitening and moisturizing essence composition, which comprises an A-phase component, a B-phase component and a C-phase component, wherein the A-phase component comprises the following raw materials: water, butanediol, thickening stabilizer, glycereth-26, dipotassium glycyrrhizinate, sodium hyaluronate and panthenol; the phase B component comprises the following raw materials: water, tetrahydropyrimidine carboxylic acid, carnosine; the C phase component comprises the following raw materials: nano-coated butyl resorcinol, purslane hydrosol, triethanolamine, glabridin high-purity water solution and a bacteriostatic agent; the whitening and moisturizing essence composition and the preparation method thereof can enter into the keratinous tissue gaps of the face, and the nutrition ingredients can enter into the fixed layer, so that the whitening and moisturizing essence composition has high absorptivity, good utilization rate and stable product activity.
Description
Technical Field
The invention relates to a whitening and moisturizing essence composition and a preparation method thereof.
Background
The prior market whitening cosmetics generally have the minimum molecules above 500 nanometers, and the keratin tissue gaps of the face are about 50-100 nanometers, so that the nutrients cannot enter into the fixed layer, the absorptivity is less than thousandths, the utilization rate is poor, the product activity is unstable, and the like.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide the whitening and moisturizing essence composition which can enter into the keratinous tissue gaps of the face, has high absorptivity and good utilization rate, and has stable product activity, and the preparation method thereof.
The technical scheme adopted for solving the technical problems is as follows:
a whitening and moisturizing essence composition comprises an A phase component, a B phase component and a C phase component, wherein,
the phase A component comprises the following raw materials: water, butanediol, thickening stabilizer, glycereth-26, dipotassium glycyrrhizinate, sodium hyaluronate and panthenol;
the phase B component comprises the following raw materials: water, tetrahydropyrimidine carboxylic acid, carnosine;
the C phase component comprises the following raw materials: nano-encapsulated butyl resorcinol, purslane hydrosol, triethanolamine, glabridin high-purity water solution and a bacteriostatic agent.
Preferably, the phase A component comprises the following raw materials in parts by weight: 70-75 parts of water, 5-10 parts of butanediol, 0.1-0.3 part of thickening stabilizer, 0.05-0.3 part of glycereth-261-5 part of dipotassium glycyrrhizinate, 0.05-0.3 part of sodium hyaluronate and 0.1-1 part of panthenol;
the phase B component comprises the following raw materials in parts by weight: 1-5 parts of water, 0.5-2 parts of tetrahydropyrimidine carboxylic acid and 0.1-0.5 part of carnosine;
the C phase component comprises the following raw materials in parts by weight: 1-4 parts of nano-coated butyl resorcinol, 1-10 parts of purslane hydrosol, 0.1-0.3 part of triethanolamine, 1-3 parts of glabridin high-purity water solution and 0.5-1 part of bacteriostat.
Preferably, the phase A component comprises the following raw materials in parts by weight: 70 parts of water, 5 parts of butanediol, 0.1 part of thickening stabilizer, 0.05 part of glycerolyether-261 part, 0.05 part of dipotassium glycyrrhizinate, 0.05 part of sodium hyaluronate and 0.1 part of panthenol;
the phase B component comprises the following raw materials in parts by weight: 1 part of water, 0.5 part of tetrahydropyrimidine carboxylic acid and 0.1 part of carnosine;
the C phase component comprises the following raw materials in parts by weight: 1 part of nano-encapsulated butyl resorcinol, 1 part of purslane hydrosol, 0.1 part of triethanolamine, 1 part of glabridin high-purity water solution and 0.5 part of bacteriostat.
Preferably, the phase A component comprises the following raw materials in parts by weight: 75 parts of water, 10 parts of butanediol, 0.3 part of thickening stabilizer, 265 parts of glycereth-0.3 part of dipotassium glycyrrhizinate, 0.3 part of sodium hyaluronate and 1 part of panthenol;
the phase B component comprises the following raw materials in parts by weight: 5 parts of water, 2 parts of tetrahydropyrimidine carboxylic acid and 0.5 part of carnosine;
the C phase component comprises the following raw materials in parts by weight: 4 parts of nano-encapsulated butyl resorcinol, 10 parts of purslane hydrosol, 0.3 part of triethanolamine, 3 parts of glabridin high-purity water solution and 1 part of bacteriostatic agent.
Preferably, the phase A component comprises the following raw materials in parts by weight: 72.89 parts of water, 8 parts of butanediol, 0.18 part of thickening stabilizer, 263 parts of glycerolyether, 0.2 part of dipotassium glycyrrhizinate, 0.15 part of sodium hyaluronate and 0.5 part of panthenol;
the phase B component comprises the following raw materials in parts by weight: 3 parts of water, 1 part of tetrahydropyrimidine carboxylic acid and 0.3 part of carnosine;
the C phase component comprises the following raw materials in parts by weight: 3 parts of nano-coated butyl resorcinol, 5 parts of purslane hydrosol, 0.18 part of triethanolamine, 2 parts of glabridin high-purity water solution and 0.6 part of bacteriostatic agent.
Preferably, the thickening stabilizer is an acrylic ester/C10-30 alkanol acrylate cross-linked polymer.
Preferably, the nano-encapsulated butyl resorcinol comprises water, glycerol, caprylic/capric triglyceride, 4-butyl resorcinol, phospholipids and tocopheryl acetate.
Preferably, the purslane hydrosol comprises purslane extract, butanediol, 1, 2-hexanediol and octanoyl hydroxamic acid.
Preferably, the glabridin high-purity water solution comprises water, hydroxypropyl cyclodextrin, 1, 2-pentanediol and glabridin root extract, and the antibacterial agent comprises phenoxyethanol and ethylhexyl glycerol.
The invention provides a preparation method of a whitening and moisturizing essence composition, which comprises the following steps of:
sequentially weighing the phase A components, adding into an emulsifying pot, heating to 80-85deg.C, starting a homogenizer, homogenizing for 3-5min, homogenizing and dissolving completely, maintaining the temperature for 20-40min, and vacuum cooling;
when the temperature is reduced to 40 ℃, adding the dissolved phase B which is stirred by a container outside in advance, and stirring uniformly;
when the temperature is reduced to below 38 ℃, all components of the phase C are respectively added, stirred uniformly, then sampled and inspected, and filtered and discharged by a filter cloth with 150-250 meshes after being qualified.
The beneficial effects of the invention are as follows:
the nanometer coated butyl resorcinol is prepared by a micro-lipid capsule slow release technology, the micro-lipid capsule slow release technology is a nanometer active substance with the grain diameter smaller than 50nm developed by the most top technology in the existing skin care product permeation technology, penetrates through the surface layer of skin to be transported to a place where the skin is required, is instantly absorbed by the skin, can improve the stability of other active substances in the product, promote the absorption, reduce the irritation of the product, and is matched with the glabridin high-purity water solution coated by hydroxypropyl cyclodextrin, so that the active ingredients with the effects of whitening and lightening spots in the product are absorbed for the skin more quickly and better, and the effect of whitening and brightening the skin is achieved.
Detailed Description
The principles and features of the present invention are described below with examples given for the purpose of illustration only and are not intended to limit the scope of the invention. The invention is more specifically described by way of example in the following paragraphs. Advantages and features of the invention will become more apparent from the following description and from the claims.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
Example 1
A whitening and moisturizing essence composition comprises an A phase component, a B phase component and a C phase component, wherein,
the phase A component comprises the following raw materials in parts by weight: 70 parts of water, 5 parts of butanediol, 0.1 part of thickening stabilizer, 0.05 part of glycerolyether-261 part, 0.05 part of dipotassium glycyrrhizinate, 0.05 part of sodium hyaluronate and 0.1 part of panthenol;
the phase B component comprises the following raw materials in parts by weight: 1 part of water, 0.5 part of tetrahydropyrimidine carboxylic acid and 0.1 part of carnosine;
the C phase component comprises the following raw materials in parts by weight: 1 part of nano-encapsulated butyl resorcinol, 1 part of purslane hydrosol, 0.1 part of triethanolamine, 1 part of glabridin high-purity water solution and 0.5 part of bacteriostat.
The thickening stabilizer is acrylic ester/C10-30 alkanol acrylic ester cross-linked polymer.
The nano-encapsulated butyl resorcinol comprises water, glycerol, caprylic/capric triglyceride, 4-butyl resorcinol, phospholipid and tocopheryl acetate.
The purslane hydrosol comprises purslane extract, butanediol, 1, 2-hexanediol and octanoyl hydroxamic acid.
The glabridin high-purity water solution comprises water, hydroxypropyl cyclodextrin, 1, 2-pentanediol and glabridin root extract, and the antibacterial agent comprises phenoxyethanol and ethylhexyl glycerol.
Example 2
A whitening and moisturizing essence composition comprises an A phase component, a B phase component and a C phase component, wherein,
the phase A component comprises the following raw materials in parts by weight: 75 parts of water, 10 parts of butanediol, 0.3 part of thickening stabilizer, 265 parts of glycereth-0.3 part of dipotassium glycyrrhizinate, 0.3 part of sodium hyaluronate and 1 part of panthenol;
the phase B component comprises the following raw materials in parts by weight: 5 parts of water, 2 parts of tetrahydropyrimidine carboxylic acid and 0.5 part of carnosine;
the C phase component comprises the following raw materials in parts by weight: 4 parts of nano-encapsulated butyl resorcinol, 10 parts of purslane hydrosol, 0.3 part of triethanolamine, 3 parts of glabridin high-purity water solution and 1 part of bacteriostatic agent.
The thickening stabilizer is acrylic ester/C10-30 alkanol acrylic ester cross-linked polymer.
The nano-encapsulated butyl resorcinol comprises water, glycerol, caprylic/capric triglyceride, 4-butyl resorcinol, phospholipid and tocopheryl acetate.
The purslane hydrosol comprises purslane extract, butanediol, 1, 2-hexanediol and octanoyl hydroxamic acid.
The glabridin high-purity water solution comprises water, hydroxypropyl cyclodextrin, 1, 2-pentanediol and glabridin root extract, and the antibacterial agent comprises phenoxyethanol and ethylhexyl glycerol.
Example 3
The whitening and moisturizing essence composition comprises an A-phase component, a B-phase component and a C-phase component, wherein the A-phase component comprises the following raw materials in parts by weight: 72.89 parts of water, 8 parts of butanediol, 0.18 part of thickening stabilizer, 263 parts of glycerolyether, 0.2 part of dipotassium glycyrrhizinate, 0.15 part of sodium hyaluronate and 0.5 part of panthenol;
the phase B component comprises the following raw materials in parts by weight: 3 parts of water, 1 part of tetrahydropyrimidine carboxylic acid and 0.3 part of carnosine;
the C phase component comprises the following raw materials in parts by weight: 3 parts of nano-coated butyl resorcinol, 5 parts of purslane hydrosol, 0.18 part of triethanolamine, 2 parts of glabridin high-purity water solution and 0.6 part of bacteriostatic agent.
The thickening stabilizer is acrylic ester/C10-30 alkanol acrylic ester cross-linked polymer.
The nano-encapsulated butyl resorcinol comprises water, glycerol, caprylic/capric triglyceride, 4-butyl resorcinol, phospholipid and tocopheryl acetate.
The purslane hydrosol comprises purslane extract, butanediol, 1, 2-hexanediol and octanoyl hydroxamic acid.
The glabridin high-purity water solution comprises water, hydroxypropyl cyclodextrin, 1, 2-pentanediol and glabridin root extract, and the antibacterial agent comprises phenoxyethanol and ethylhexyl glycerol.
Example 4
A preparation method of a whitening and moisturizing essence composition comprises the following steps:
70 parts of water, 5 parts of butanediol, 0.1 part of thickening stabilizer, 261 parts of glycerolyether, 0.05 part of dipotassium glycyrrhizinate, 0.05 part of sodium hyaluronate and 0.1 part of panthenol are added into an emulsifying pot, heated to 80 ℃, a homogenizer is started, homogenized for 3min, homogenized and dissolved completely, heat preservation is carried out for 20min, and vacuum cooling is carried out;
when the temperature is reduced to 40 ℃, adding 1 part of water, 0.5 part of tetrahydropyrimidine carboxylic acid and 0.1 part of carnosine which are stirred and dissolved in a container in advance outside, and uniformly stirring;
when the temperature is reduced to below 38 ℃,1 part of nano-coated butyl resorcinol, 1 part of purslane hydrosol, 0.1 part of triethanolamine, 1 part of glabridin high-purity water solution and 0.5 part of bacteriostat are respectively added, uniformly stirred, then sampled and inspected, and filtered by a 150-mesh filter cloth to be discharged after being qualified.
Example 5
A preparation method of a whitening and moisturizing essence composition comprises the following steps:
adding 75 parts of water, 10 parts of butanediol, 0.3 part of thickening stabilizer, 265 parts of glycerolyether, 0.3 part of dipotassium glycyrrhizinate, 0.3 part of sodium hyaluronate and 1 part of panthenol into an emulsifying pot, heating to 85 ℃, starting a homogenizer, homogenizing for 5min, homogenizing and dissolving completely, preserving heat for 40min, and vacuum cooling;
when the temperature is reduced to 40 ℃, adding 5 parts of water, 2 parts of tetrahydropyrimidine carboxylic acid and 0.5 part of carnosine which are stirred and dissolved in a container in advance outside, and uniformly stirring;
when the temperature is reduced to below 38 ℃, 4 parts of nano-coated butyl resorcinol, 10 parts of purslane hydrosol, 0.3 part of triethanolamine, 3 parts of glabridin high-purity water solution and 1 part of bacteriostat are respectively added, uniformly stirred, then sampled and inspected, and the qualified products are filtered and discharged by a 250-mesh filter cloth.
Example 6
A preparation method of a whitening and moisturizing essence composition comprises the following steps:
adding 72.89 parts of water, 8 parts of butanediol, 0.18 part of thickening stabilizer, 263 parts of glycerolyether, 0.2 part of dipotassium glycyrrhizinate, 0.15 part of sodium hyaluronate and 0.5 part of panthenol into an emulsifying pot, heating to 80 ℃, starting a homogenizer, homogenizing for 4min, homogenizing and dissolving completely, preserving heat for 20-40min, and vacuum cooling;
when the temperature is reduced to 40 ℃, adding 3 parts of water, 1 part of tetrahydropyrimidine carboxylic acid and 0.3 part of carnosine which are stirred and dissolved in a container in advance outside, and uniformly stirring;
when the temperature is reduced to below 38 ℃, 3 parts of nano-coated butyl resorcinol, 5 parts of purslane hydrosol, 0.18 part of triethanolamine, 2 parts of glabridin high-purity water solution and 0.6 part of bacteriostat are respectively added, uniformly stirred, then sampled and inspected, and filtered by a 200-mesh filter cloth to be discharged after being qualified.
Comparative example 1:
a preparation method of a whitening and moisturizing essence composition comprises the following steps:
adding 72.89 parts of water, 8 parts of butanediol, 0.18 part of thickening stabilizer, 263 parts of glycerolyether, 0.2 part of dipotassium glycyrrhizinate, 0.15 part of sodium hyaluronate and 0.5 part of panthenol into an emulsifying pot, heating to 80 ℃, starting a homogenizer, homogenizing for 4min, homogenizing and dissolving completely, preserving heat for 20-40min, and vacuum cooling;
when the temperature is reduced to 40 ℃, adding 3 parts of water, 1 part of tetrahydropyrimidine carboxylic acid and 0.3 part of carnosine which are stirred and dissolved in a container in advance outside, and uniformly stirring;
when the temperature is reduced to below 38 ℃, 5 parts of purslane hydrosol, 0.18 part of triethanolamine, 2 parts of glabridin high-purity water solution and 0.6 part of bacteriostat are respectively added, uniformly stirred, then sampling and inspection are carried out, and after the purslane hydrosol is qualified, 200-mesh filter cloth is used for filtering and discharging.
Comparative example 2:
a preparation method of a whitening and moisturizing essence composition comprises the following steps:
adding 72.89 parts of water, 8 parts of butanediol, 0.18 part of thickening stabilizer, 263 parts of glycerolyether, 0.2 part of dipotassium glycyrrhizinate, 0.15 part of sodium hyaluronate and 0.5 part of panthenol into an emulsifying pot, heating to 80 ℃, starting a homogenizer, homogenizing for 4min, homogenizing and dissolving completely, preserving heat for 20-40min, and vacuum cooling;
when the temperature is reduced to 40 ℃, adding 3 parts of water, 1 part of tetrahydropyrimidine carboxylic acid and 0.3 part of carnosine which are stirred and dissolved in a container in advance outside, and uniformly stirring;
when the temperature is reduced to below 38 ℃, respectively adding 3 parts of nano-coated butyl resorcinol, 5 parts of purslane hydrosol, 0.18 part of triethanolamine and 0.6 part of bacteriostat, uniformly stirring, sampling, inspecting, and filtering and discharging with 200-mesh filter cloth after passing the inspection.
Experimental example 1
Safety evaluation was performed on the whitening and moisturizing essence compositions prepared in examples 4 to 6.
The group of subjects was females, 100, between 20 and 40 years of age. The skin of the subject is healthy, no skin disease allergy history exists, and the subject's volunteer selection standard is met. Randomly, 5 groups of 20 persons each.
Selecting a qualified spot tester, dripping about 0.015ml to 0.025ml of a test object into the spot tester in a closed spot pasting test mode, pasting a special adhesive tape on the back of a subject, removing the test object after 24 hours, observing skin reaction after 0.5, 6, 12, 24 and 48 hours respectively, and recording the result according to the skin reaction grading standard in the cosmetic hygiene Specification.
The human skin patch experiment result shows that: each group of subjects observed skin reactions by examples 4 to 6 at 12, 24 and 48 hours, respectively, wherein 0 cases showed skin adverse reactions, demonstrating that the whitening and moisturizing essence composition prepared by the present invention was safe to use.
Experimental example 2
The whitening and moisturizing essence compositions prepared in the above examples 4 to 6 and comparative examples 1 to 2 were subjected to trial evaluation.
100 subjects, aged in the range of 20-50 years, 50 females and 50 males. The skin of the subject is healthy, no skin disease allergy history exists, and the volunteer selection standard of the subject is met. Subjects were randomized into 5 groups of 20 persons each, 10 persons each for men and women.
The subjects observed and experienced the effects of use using the whitening and moisturizing essence compositions prepared in examples 4-6 and comparative examples 1-2, respectively. After the face of the subject is cleaned, a proper amount of the whitening and moisturizing essence is taken, uniformly smeared on the face, gently massaged to the skin for absorption, used once a day in the morning and evening, the service cycle is four weeks, and the result is recorded in detail.
Test evaluation results: the results of the permeability and absorbency effect evaluation of inventive examples 4-6 and comparative examples 1-2 are shown in Table 1; the evaluation of whitening and moisturizing effects of examples 4 to 6 and comparative examples 1 to 2 of the present invention is shown in Table 2.
TABLE 1
Permeability and absorbency effects
| Very good | Preferably, it is | In general | Poor quality | Very poor | |
| Example 4 | 18 | 2 | 0 | 0 | 0 |
| Example 5 | 20 | 0 | 0 | 0 | 0 |
| Example 6 | 20 | 0 | 0 | 0 | 0 |
| Comparative example 1 | 20 | 0 | 0 | 0 | 0 |
| Comparative example 2 | 8 | 4 | 3 | 5 | 0 |
TABLE 2
Whitening and moisturizing effects
| Very good | Preferably, it is | In general | Poor quality | Very poor | |
| Example 4 | 16 | 4 | 0 | 0 | 0 |
| Example 5 | 20 | 0 | 0 | 0 | 0 |
| Example 6 | 18 | 2 | 0 | 0 | 0 |
| Comparative example 1 | 4 | 8 | 6 | 2 | 0 |
| Comparative example 2 | 8 | 8 | 4 | 0 | 0 |
According to the results, the use of the nano-encapsulated butyl resorcinol enables the whitening and moisturizing essence composition to have a better permeation effect, meanwhile, the whitening and moisturizing essence composition can be better absorbed by skin, and the glabridin high-purity water solution can enable the whitening and freckle-fading active ingredient to be absorbed by skin more quickly and better, so that the whitening and skin-brightening effect is improved. And as each component in the whitening and moisturizing essence composition increases, the effect is further enhanced, and the most excellent effect is achieved in the component ratio of example 5.
The beneficial effects of the invention are as follows:
the nanometer coated butyl resorcinol is prepared by a micro-lipid capsule slow release technology, the micro-lipid capsule slow release technology is a nanometer active substance with the grain diameter smaller than 50nm developed by the most top technology in the existing skin care product permeation technology, penetrates through the surface layer of skin to be transported to a place where the skin is required, is instantly absorbed by the skin, can improve the stability of other active substances in the product, promote the absorption, reduce the irritation of the product, and is matched with the glabridin high-purity water solution coated by hydroxypropyl cyclodextrin, so that the active ingredients with the effects of whitening and lightening spots in the product are absorbed for the skin more quickly and better, and the effect of whitening and brightening the skin is achieved.
The above-mentioned embodiments of the present invention are not intended to limit the scope of the present invention, and the embodiments of the present invention are not limited thereto, and all kinds of modifications, substitutions or alterations made to the above-mentioned structures of the present invention according to the above-mentioned general knowledge and conventional means of the art without departing from the basic technical ideas of the present invention shall fall within the scope of the present invention.
Claims (10)
1. A whitening and moisturizing essence composition is characterized in that: comprises an A phase component, a B phase component and a C phase component, wherein,
the phase A component comprises the following raw materials: water, butanediol, thickening stabilizer, glycereth-26, dipotassium glycyrrhizinate, sodium hyaluronate and panthenol;
the phase B component comprises the following raw materials: water, tetrahydropyrimidine carboxylic acid, carnosine;
the C phase component comprises the following raw materials: nano-encapsulated butyl resorcinol, purslane hydrosol, triethanolamine, glabridin high-purity water solution and a bacteriostatic agent.
2. The whitening and moisturizing essence composition according to claim 1, wherein: the phase A component comprises the following raw materials in parts by weight: 70-75 parts of water, 5-10 parts of butanediol, 0.1-0.3 part of thickening stabilizer, 0.05-0.3 part of glycereth-261-5 part of dipotassium glycyrrhizinate, 0.05-0.3 part of sodium hyaluronate and 0.1-1 part of panthenol;
the phase B component comprises the following raw materials in parts by weight: 1-5 parts of water, 0.5-2 parts of tetrahydropyrimidine carboxylic acid and 0.1-0.5 part of carnosine;
the C phase component comprises the following raw materials in parts by weight: 1-4 parts of nano-coated butyl resorcinol, 1-10 parts of purslane hydrosol, 0.1-0.3 part of triethanolamine, 1-3 parts of glabridin high-purity water solution and 0.5-1 part of bacteriostat.
3. The whitening and moisturizing essence composition according to claim 2, characterized in that: the phase A component comprises the following raw materials in parts by weight: 70 parts of water, 5 parts of butanediol, 0.1 part of thickening stabilizer, 0.05 part of glycerolyether-261 part, 0.05 part of dipotassium glycyrrhizinate, 0.05 part of sodium hyaluronate and 0.1 part of panthenol;
the phase B component comprises the following raw materials in parts by weight: 1 part of water, 0.5 part of tetrahydropyrimidine carboxylic acid and 0.1 part of carnosine;
the C phase component comprises the following raw materials in parts by weight: 1 part of nano-encapsulated butyl resorcinol, 1 part of purslane hydrosol, 0.1 part of triethanolamine, 1 part of glabridin high-purity water solution and 0.5 part of bacteriostat.
4. The whitening and moisturizing essence composition according to claim 2, characterized in that: the phase A component comprises the following raw materials in parts by weight: 75 parts of water, 10 parts of butanediol, 0.3 part of thickening stabilizer, 265 parts of glycereth-0.3 part of dipotassium glycyrrhizinate, 0.3 part of sodium hyaluronate and 1 part of panthenol;
the phase B component comprises the following raw materials in parts by weight: 5 parts of water, 2 parts of tetrahydropyrimidine carboxylic acid and 0.5 part of carnosine;
the C phase component comprises the following raw materials in parts by weight: 4 parts of nano-encapsulated butyl resorcinol, 10 parts of purslane hydrosol, 0.3 part of triethanolamine, 3 parts of glabridin high-purity water solution and 1 part of bacteriostatic agent.
5. The whitening and moisturizing essence composition according to claim 2, characterized in that: the phase A component comprises the following raw materials in parts by weight: 72.89 parts of water, 8 parts of butanediol, 0.18 part of thickening stabilizer, 263 parts of glycerolyether, 0.2 part of dipotassium glycyrrhizinate, 0.15 part of sodium hyaluronate and 0.5 part of panthenol;
the phase B component comprises the following raw materials in parts by weight: 3 parts of water, 1 part of tetrahydropyrimidine carboxylic acid and 0.3 part of carnosine;
the C phase component comprises the following raw materials in parts by weight: 3 parts of nano-coated butyl resorcinol, 5 parts of purslane hydrosol, 0.18 part of triethanolamine, 2 parts of glabridin high-purity water solution and 0.6 part of bacteriostatic agent.
6. The whitening and moisturizing concentrate composition of any one of claims 1-5, wherein: the thickening stabilizer is acrylic ester/C10-30 alkanol acrylic ester cross-linked polymer.
7. The whitening and moisturizing concentrate composition of any one of claims 1-5, wherein: the nano-encapsulated butyl resorcinol comprises water, glycerol, caprylic/capric triglyceride, 4-butyl resorcinol, phospholipid and tocopheryl acetate.
8. The whitening and moisturizing concentrate composition of any one of claims 1-5, wherein: the purslane hydrosol comprises purslane extract, butanediol, 1, 2-hexanediol and octanoyl hydroxamic acid.
9. The whitening and moisturizing concentrate composition of any one of claims 1-5, wherein: the glabridin high-purity water solution comprises water, hydroxypropyl cyclodextrin, 1, 2-pentanediol and glabridin root extract, and the antibacterial agent comprises phenoxyethanol and ethylhexyl glycerol.
10. The preparation method of the whitening and moisturizing essence composition is characterized by comprising the following steps of:
sequentially weighing the phase A components, adding into an emulsifying pot, heating to 80-85deg.C, starting a homogenizer, homogenizing for 3-5min, homogenizing and dissolving completely, maintaining the temperature for 20-40min, and vacuum cooling;
when the temperature is reduced to 40 ℃, adding the dissolved phase B which is stirred by a container outside in advance, and stirring uniformly;
when the temperature is reduced to below 38 ℃, all components of the phase C are respectively added, stirred uniformly, then sampled and inspected, and filtered and discharged by a filter cloth with 150-250 meshes after being qualified.
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| CN113693958A (en) * | 2020-10-09 | 2021-11-26 | 广州俏姿颜化妆品有限公司 | Glabridin mask and preparation method thereof |
| CN115137687A (en) * | 2022-08-05 | 2022-10-04 | 杭州槿美生物科技有限公司 | Mask liquid composition with effects of relieving, tightening and resisting wrinkles |
| CN115177542A (en) * | 2022-08-19 | 2022-10-14 | 杭州弘玺生物科技有限公司 | Preparation method of facial essence |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111714390A (en) * | 2019-03-19 | 2020-09-29 | 西安博鸿生物技术有限公司 | Whitening essence milk and preparation method thereof |
| CN113693958A (en) * | 2020-10-09 | 2021-11-26 | 广州俏姿颜化妆品有限公司 | Glabridin mask and preparation method thereof |
| CN112386552A (en) * | 2020-12-08 | 2021-02-23 | 广州名妆化妆品制造有限公司 | Preparation method of compound freckle-removing and whitening composition |
| CN115137687A (en) * | 2022-08-05 | 2022-10-04 | 杭州槿美生物科技有限公司 | Mask liquid composition with effects of relieving, tightening and resisting wrinkles |
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