CN116327616A - Formula and preparation process of whitening and skin-tendering body milk - Google Patents

Formula and preparation process of whitening and skin-tendering body milk Download PDF

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Publication number
CN116327616A
CN116327616A CN202310445768.9A CN202310445768A CN116327616A CN 116327616 A CN116327616 A CN 116327616A CN 202310445768 A CN202310445768 A CN 202310445768A CN 116327616 A CN116327616 A CN 116327616A
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whitening
skin
phase
stirring
agent
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彭斯祺
彭晓丹
陈小连
吴旭成
彭再辉
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Guangzhou Aole Cosmetics Co ltd
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Guangzhou Aole Cosmetics Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/891Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a formula of whitening and skin tendering body milk and a preparation process thereof, wherein the formula comprises the following components in parts by weight: 12-15 parts of an emollient, 5-6 parts of a humectant, 2-3 parts of a whitening agent, 3-4 parts of an emulsifying agent, 1.5-2 parts of a thickening agent, 1 part of a physical whitening agent, 0.8 part of a preservative, 0.3 part of an antioxidant, 0.2 part of an astringent, 0.05 part of a chelating agent, 0.5 part of an aromatic and the balance of water.

Description

Formula and preparation process of whitening and skin-tendering body milk
Technical Field
The invention relates to the technical field of body milk, in particular to a formula of whitening and skin tendering body milk and a preparation process thereof.
Background
With seasonal changes, the intensity of sunlight and the humidity of air can change obviously, and the health of human skin can be influenced. If the skin is strongly illuminated in the south and dried in the north, the skin epidermis layer is lack of enough moisture to cause the skin to be dried, at the moment, the skin shows redness and tiny cracks, if the drying condition is serious, scales or peeling can be generated, the cracks can even generate skin cracks, the depth reaches the dermis layer, and the skin is infected and damaged.
In order to effectively avoid the skin dryness problem, besides supplementing body moisture, a plurality of mild and nonirritating skin care products can be properly selected, so that the direct contact of the skin and air is reduced, the evaporation rate of the moisture is reduced, and the skin dryness rate is reduced. However, the whitening products on the market are messy, some merchants add a large amount of chemicals harmful to human bodies in the skin care products in order to achieve the effects of whitening and repairing the skin, and further add chemicals which contain medicines, hormones and the like and are limited or forbidden to the skin care products, so that the harmful substances can cause serious injury to the human bodies after long-term use.
Disclosure of Invention
The invention aims to provide a formula of whitening and skin tendering body milk and a preparation process thereof, so as to solve the problems in the background technology.
In order to achieve the above purpose, the present invention provides the following technical solutions:
a formula of whitening and skin tendering body milk comprises the following components in parts by weight: 12-15 parts of an emollient, 5-6 parts of a humectant, 2-3 parts of a whitening agent, 3-4 parts of an emulsifying agent, 1.5-2 parts of a thickening agent, 1 part of a physical whitening agent, 0.8 part of a preservative, 0.3 part of an antioxidant, 0.2 part of an astringent, 0.05 part of a chelating agent, 0.5 part of an aromatic agent and the balance of water.
As a further scheme of the invention: the emollient comprises mineral oil, caprylic/capric triglyceride, cyclomethicone and butter fruit tree fruit fat; the humectant is glycerin.
As a further scheme of the invention: the whitening agent comprises nicotinamide and arbutin; the synthesis process of arbutin comprises the following steps: step one, condensation: adding 1200-1500kg of dichloromethane into a reaction kettle, adding 200-230kg of monoacetylhydroquinone and 510-540kg of pentaacetylglucose, sealing, cooling to 5-10 ℃ and dropwise adding boron trifluoride acetic acid solution for one hour, stopping cooling liquid after dropwise adding, heating and refluxing to react at the jacket temperature of 40-50 ℃ for 5-7 hours; step two, washing: after the condensation reaction is finished and the temperature is reduced to below 20 ℃, 550 kg to 650kg of purified water is added into the reaction product for washing; separating, removing a water layer, adding 350-450kg of 1-3% NaOH aqueous solution into the organic layer for alkaline washing, and controlling the pH of the water layer to be 7-8; separating, discarding a water layer, and distilling an organic layer to recover dichloromethane; the organic layer is distilled under normal pressure and distilled under reduced pressure to remove dichloromethane, the temperature of the normal pressure distillation is controlled to be 45 ℃, and the total time of the normal pressure distillation and the reduced pressure distillation is controlled to be 6-8 hours; step three, crystallizing: adding 800-1200kg of absolute ethyl alcohol into the organic layer, stirring for 1.5-2.5 hours at 45-55 ℃, and then cooling for crystallization; centrifuging when the temperature is reduced to 5-10 ℃, distilling the centrifugated mother liquor to recover ethanol, applying the recovered ethanol to crystallization, and drying the centrifugated solid which is pentaacetyl arbutin by double cones for later use; step four, alcoholysis: adding 1900-2200kg of methanol into a reaction kettle, adding 560-600kg of pentaacetyl arbutin, heating, adding 2-5kg of sodium methoxide when the temperature in the kettle reaches 45-55 ℃, heating to 60-70 ℃ for heating reflux reaction, and reacting for 3-4 hours; step five, neutralization and decolorization: cooling the alcoholysis reaction product to 23-28 ℃, regulating the pH value to 6-7 by acetic acid, adding 0.5-1.5kg of activated carbon for decoloring, and stirring for 0.5-1.5 hours; then filtering, and distilling the filtrate to remove methanol and methyl acetate; step six, recrystallizing: adding 800-1200kg of methyl acetate into the filtrate, heating to 45-55 ℃ for pulping for 1.5-2.5 hours, then stirring and cooling to 5-10 ℃ for centrifugation, and obtaining a filter cake which is an arbutin crude product; adding 800-1200g of purified water into arbutin crude product, heating to 60-70deg.C for dissolution, filtering, cooling for crystallization, and stirring during crystallization; centrifuging when the temperature is reduced to 5-10deg.C, and drying the centrifuged solid to obtain arbutin product.
As a further scheme of the invention: the emulsifier includes polysorbate-60 and sorbitan stearate.
As a further scheme of the invention: the thickening agent comprises cetostearyl alcohol and xanthan gum.
As a further scheme of the invention: the physical whitening agent is titanium dioxide; the antioxidant is tocopheryl acetate.
As a further scheme of the invention: the preservative comprises phenoxyethanol and ethylhexyl glycerol.
As a further scheme of the invention: the astringent is allantoin; the chelating agent is disodium EDTA.
As still further aspects of the invention: the aromatic is essence; the essence comprises the following components: limonene, vanillyl alcohol, styrene, geraniol, linalool, rose ether, heliotropin, methylhexylcinnamaldehyde, mugwort aldehyde, ethyl acetate, liu Suanshe alcohol ester, n-amyl salicylate, benzyl acetate, methyl dihydrojasmonate, linalyl acetate, ethyl 2, 4-decadienoate, lemon oil, patchouli oil, and flavoring agents, modifiers, fixatives and water.
A preparation process of whitening and skin tendering body milk comprises the following steps:
the first step: heating the phase A to 85 ℃, preserving heat for 20 minutes to 80 ℃, and stirring and dissolving completely for later use;
and a second step of: heating phase B to 90 ℃, wherein the powder is completely dispersed, preserving heat for 20 minutes to 80 ℃, adding phase B1, stirring and dissolving completely for later use;
and a third step of: pumping the mixed phase B into a preheated emulsifying pot, slowly pumping the mixed phase A into the emulsifying pot, pre-emulsifying for 10 minutes, homogenizing for 5-10 minutes, uniformly stirring, vacuumizing, defoaming and cooling;
adding the phase C at 65 ℃ and uniformly stirring; adding phase D at 40 ℃, stirring uniformly, and discharging after physical and chemical indexes are checked to be qualified;
fifth step: after the semi-finished product is inspected to be qualified, filling, packaging, code spraying, and warehousing after the finished product is inspected to be qualified;
wherein, the A phase raw materials comprise mineral oil, caprylic/capric triglyceride, cyclomethicone, pyritan stearate, shea butter, tocopheryl acetate, polysorbate-60 and cetostearyl alcohol; phase B raw materials: water, nicotinamide, allantoin, disodium EDTA, and titanium dioxide; b1 phase raw materials: glycerol, xanthan gum; c phase raw materials: arbutin; d phase raw materials: essence, phenoxyethanol and ethylhexyl glycerol.
Compared with the prior art, the invention has the beneficial effects that: according to the formula and the preparation process of the whitening and tendering body milk, the components in the whitening and tendering body milk are provided, and the weight parts of the components in the whitening and tendering body milk are adjusted, so that the whitening and tendering body milk has good mildness and moisture retention, can increase the brightness of skin, and better ensures the efficacy of the whitening and tendering body milk.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Detailed Description
Example 1
In one embodiment, as shown in fig. 1, a whitening and skin rejuvenating body lotion formulation, comprises the following components by weight: 12 parts of an emollient, 5 parts of a humectant, 2 parts of a whitening agent, 3 parts of an emulsifying agent, 1.5 parts of a thickening agent, 1 part of a physical whitening agent, 0.8 part of a preservative, 0.3 part of an antioxidant, 0.2 part of an astringent, 0.05 part of a chelating agent, 0.5 part of a aromatic and the balance of water;
example 2
In one embodiment, as shown in fig. 1, a whitening and skin rejuvenating body lotion formulation, comprises the following components by weight: 13 parts of an emollient, 5.5 parts of a humectant, 2.5 parts of a whitening agent, 3.3 parts of an emulsifying agent, 1.65 parts of a thickening agent, 1 part of a physical whitening agent, 0.8 part of a preservative, 0.3 part of an antioxidant, 0.2 part of an astringent, 0.05 part of a chelating agent, 0.5 part of a aromatic agent and the balance of water;
example 3
In one embodiment, as shown in fig. 1, a whitening and skin rejuvenating body lotion formulation, comprises the following components by weight: 15 parts of an emollient, 6 parts of a humectant, 3 parts of a whitening agent, 4 parts of an emulsifying agent, 2 parts of a thickening agent, 1 part of a physical whitening agent, 0.8 part of a preservative, 0.3 part of an antioxidant, 0.2 part of an astringent, 0.05 part of a chelating agent, 0.5 part of a aromatic and the balance of water;
the emollient comprises mineral oil, caprylic/capric triglyceride, cyclomethicone, and butter fruit; the humectant is glycerin.
The whitening agent comprises nicotinamide and arbutin; the synthesis process of arbutin comprises the following steps: step one, condensation: adding 1200-1500kg of dichloromethane into a reaction kettle, adding 200-230kg of monoacetylhydroquinone and 510-540kg of pentaacetylglucose, sealing, cooling to 5-10 ℃ and dropwise adding boron trifluoride acetic acid solution for one hour, stopping cooling liquid after dropwise adding, heating and refluxing to react at the jacket temperature of 40-50 ℃ for 5-7 hours; step two, washing: after the condensation reaction is finished and the temperature is reduced to below 20 ℃, 550 kg to 650kg of purified water is added into the reaction product for washing; separating, removing a water layer, adding 350-450kg of 1-3% NaOH aqueous solution into the organic layer for alkaline washing, and controlling the pH of the water layer to be 7-8; separating, discarding a water layer, and distilling an organic layer to recover dichloromethane; the organic layer is distilled under normal pressure and distilled under reduced pressure to remove dichloromethane, the temperature of the normal pressure distillation is controlled to be 45 ℃, and the total time of the normal pressure distillation and the reduced pressure distillation is controlled to be 6-8 hours; step three, crystallizing: adding 800-1200kg of absolute ethyl alcohol into the organic layer, stirring for 1.5-2.5 hours at 45-55 ℃, and then cooling for crystallization; centrifuging when the temperature is reduced to 5-10 ℃, distilling the centrifugated mother liquor to recover ethanol, applying the recovered ethanol to crystallization, and drying the centrifugated solid which is pentaacetyl arbutin by double cones for later use; step four, alcoholysis: adding 1900-2200kg of methanol into a reaction kettle, adding 560-600kg of pentaacetyl arbutin, heating, adding 2-5kg of sodium methoxide when the temperature in the kettle reaches 45-55 ℃, heating to 60-70 ℃ for heating reflux reaction, and reacting for 3-4 hours; step five, neutralization and decolorization: cooling the alcoholysis reaction product to 23-28 ℃, regulating the pH value to 6-7 by acetic acid, adding 0.5-1.5kg of activated carbon for decoloring, and stirring for 0.5-1.5 hours; then filtering, and distilling the filtrate to remove methanol and methyl acetate; step six, recrystallizing: adding 800-1200kg of methyl acetate into the filtrate, heating to 45-55 ℃ for pulping for 1.5-2.5 hours, then stirring and cooling to 5-10 ℃ for centrifugation, and obtaining a filter cake which is an arbutin crude product; adding 800-1200g of purified water into arbutin crude product, heating to 60-70deg.C for dissolution, filtering, cooling for crystallization, and stirring during crystallization; centrifuging when the temperature is reduced to 5-10deg.C, and drying the centrifuged solid to obtain arbutin product;
the nicotinamide is also called VB3, is an important member in vitamin families, can reduce the transfer of melanin to the horny layer of the skin, reduce the deposition of the melanin on the horny layer, avoid the blackening of the skin, obviously reduce the area and the quantity of brown spots of the skin, and can be seen with naked eyes to lighten the color of the spots of the skin. The main effects of nicotinamide are the following three points: accelerating metabolism and promoting the shedding of keratinocytes containing melanin; secondly, acting on the melanin which is produced, and reducing the transfer of the melanin to surface cells; and thirdly, promoting the synthesis of epidermal layer proteins and improving the skin texture. In solutions with pH above or below 6, nicotinamide can hydrolyze to form nicotinic acid, which can cause skin allergy and skin stinging, redness and swelling. Therefore, the pH value of the whitening body lotion is controlled within a proper range, for example, the pH value is controlled to be 6-7, and the generation of nicotinic acid can be remarkably reduced.
The emulsifier includes polysorbate-60 and sorbitan stearate. Thickening agents include cetostearyl alcohol and xanthan gum. The physical whitening agent is titanium dioxide; the antioxidant is tocopheryl acetate; the tocopheryl acetate is light yellow viscous liquid with relative density of 0.957, freezing point of-27.5 ℃, boiling point of 200-250 ℃ and refractive index of 1.495-1.4972, and is easy to dissolve in chloroform, diethyl ether, acetone and vegetable oil, dissolve in alcohol, not dissolve in water, have better heat resistance, can be oxidized when meeting light, and have deep color. Preservatives include phenoxyethanol and ethylhexyl glycerol. The astringent is allantoin, and is mainly prepared by adopting chemical synthesis methods such as urea glyoxylate direct condensation method, calcium acetate acid dissolution method, urea dichloroacetic acid heating method, oxalic acid electrolytic glyoxal oxidation method and chloral synthesis method; the chelating agent is disodium EDTA.
The aromatic is essence; the essence comprises the following components: limonene, vanillyl alcohol, styrene, geraniol, linalool, rose ether, heliotropin, methylhexylcinnamaldehyde, mugwort aldehyde, ethyl acetate, liu Suanshe alcohol ester, n-amyl salicylate, benzyl acetate, methyl dihydrojasmonate, linalyl acetate, ethyl 2, 4-decadienoate, lemon oil, patchouli oil, and flavoring agents, modifiers, fixatives and water.
A preparation process of whitening and skin tendering body milk comprises the following steps:
the first step: heating the phase A to 85 ℃, preserving heat for 20 minutes to 80 ℃, and stirring and dissolving completely for later use;
and a second step of: heating phase B to 90 ℃, wherein the powder is completely dispersed, preserving heat for 20 minutes to 80 ℃, adding phase B1, stirring and dissolving completely for later use;
and a third step of: pumping the mixed phase B into a preheated emulsifying pot, slowly pumping the mixed phase A into the emulsifying pot, pre-emulsifying for 10 minutes, homogenizing for 5-10 minutes, uniformly stirring, vacuumizing, defoaming and cooling;
adding the phase C at 65 ℃ and uniformly stirring; adding phase D at 40 ℃, stirring uniformly, and discharging after physical and chemical indexes are checked to be qualified;
fifth step: after the semi-finished product is inspected to be qualified, filling, packaging, code spraying, and warehousing after the finished product is inspected to be qualified;
wherein, the A phase raw materials comprise mineral oil, caprylic/capric triglyceride, cyclomethicone, pyritan stearate, shea butter, tocopheryl acetate, polysorbate-60 and cetostearyl alcohol; phase B raw materials: water, nicotinamide, allantoin, disodium EDTA, and titanium dioxide; b1 phase raw materials: glycerol, xanthan gum; c phase raw materials: arbutin; d phase raw materials: essence, phenoxyethanol and ethylhexyl glycerol.
The foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical scheme of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.

Claims (10)

1. The formula of the whitening and skin tendering body lotion is characterized by comprising the following components in parts by weight: 12-15 parts of an emollient, 5-6 parts of a humectant, 2-3 parts of a whitening agent, 3-4 parts of an emulsifying agent, 1.5-2 parts of a thickening agent, 1 part of a physical whitening agent, 0.8 part of a preservative, 0.3 part of an antioxidant, 0.2 part of an astringent, 0.05 part of a chelating agent, 0.5 part of an aromatic agent and the balance of water.
2. The whitening and skin rejuvenating body lotion formula according to claim 1 wherein said emollient comprises mineral oil, caprylic/capric triglyceride, cyclomethicone, shea butter; the humectant is glycerin.
3. The whitening and skin rejuvenating body lotion formula according to claim 1 wherein the whitening agent comprises niacinamide and arbutin; the synthesis process of arbutin comprises the following steps: step one, condensation: adding 1200-1500kg of dichloromethane into a reaction kettle, adding 200-230kg of monoacetylhydroquinone and 510-540kg of pentaacetylglucose, sealing, cooling to 5-10 ℃ and dropwise adding boron trifluoride acetic acid solution for one hour, stopping cooling liquid after dropwise adding, heating and refluxing to react at the jacket temperature of 40-50 ℃ for 5-7 hours; step two, washing: after the condensation reaction is finished and the temperature is reduced to below 20 ℃, 550 kg to 650kg of purified water is added into the reaction product for washing; separating, removing a water layer, adding 350-450kg of 1-3% NaOH aqueous solution into the organic layer for alkaline washing, and controlling the pH of the water layer to be 7-8; separating, discarding a water layer, and distilling an organic layer to recover dichloromethane; the organic layer is distilled under normal pressure and distilled under reduced pressure to remove dichloromethane, the temperature of the normal pressure distillation is controlled to be 45 ℃, and the total time of the normal pressure distillation and the reduced pressure distillation is controlled to be 6-8 hours; step three, crystallizing: adding 800-1200kg of absolute ethyl alcohol into the organic layer, stirring for 1.5-2.5 hours at 45-55 ℃, and then cooling for crystallization; centrifuging when the temperature is reduced to 5-10 ℃, distilling the centrifugated mother liquor to recover ethanol, applying the recovered ethanol to crystallization, and drying the centrifugated solid which is pentaacetyl arbutin by double cones for later use; step four, alcoholysis: adding 1900-2200kg of methanol into a reaction kettle, adding 560-600kg of pentaacetyl arbutin, heating, adding 2-5kg of sodium methoxide when the temperature in the kettle reaches 45-55 ℃, heating to 60-70 ℃ for heating reflux reaction, and reacting for 3-4 hours; step five, neutralization and decolorization: cooling the alcoholysis reaction product to 23-28 ℃, regulating the pH value to 6-7 by acetic acid, adding 0.5-1.5kg of activated carbon for decoloring, and stirring for 0.5-1.5 hours; then filtering, and distilling the filtrate to remove methanol and methyl acetate; step six, recrystallizing: adding 800-1200kg of methyl acetate into the filtrate, heating to 45-55 ℃ for pulping for 1.5-2.5 hours, then stirring and cooling to 5-10 ℃ for centrifugation, and obtaining a filter cake which is an arbutin crude product; adding 800-1200g of purified water into arbutin crude product, heating to 60-70deg.C for dissolution, filtering, cooling for crystallization, and stirring during crystallization; centrifuging when the temperature is reduced to 5-10deg.C, and drying the centrifuged solid to obtain arbutin product.
4. The whitening and skin rejuvenating body lotion formulation as claimed in claim 1 wherein the emulsifying agent comprises polysorbate-60 and sorbitan stearate.
5. The whitening and skin rejuvenating body lotion formulation as claimed in claim 1 wherein the thickening agent comprises cetostearyl alcohol and xanthan gum.
6. The whitening and skin rejuvenating body lotion formulation according to claim 1 wherein the physical whitening agent is titanium dioxide; the antioxidant is tocopheryl acetate.
7. The whitening and skin rejuvenating body lotion formula according to claim 1 wherein the preservative comprises phenoxyethanol and ethylhexyl glycerol.
8. The whitening and rejuvenating body lotion formulation as claimed in claim 1 wherein the astringent is allantoin; the chelating agent is disodium EDTA.
9. The whitening and skin rejuvenating body lotion formula according to claim 1 wherein the fragrance is an essence; the essence comprises the following components: limonene, vanillyl alcohol, styrene, geraniol, linalool, rose ether, heliotropin, methylhexylcinnamaldehyde, mugwort aldehyde, ethyl acetate, liu Suanshe alcohol ester, n-amyl salicylate, benzyl acetate, methyl dihydrojasmonate, linalyl acetate, ethyl 2, 4-decadienoate, lemon oil, patchouli oil, and flavoring agents, modifiers, fixatives and water.
10. A process for preparing whitening and skin-tendering body milk, which is characterized by being applied to the whitening and skin-tendering body milk formula as claimed in any one of claims 1 to 9, and comprising the following steps:
the first step: heating the phase A to 85 ℃, preserving heat for 20 minutes to 80 ℃, and stirring and dissolving completely for later use;
and a second step of: heating phase B to 90 ℃, wherein the powder is completely dispersed, preserving heat for 20 minutes to 80 ℃, adding phase B1, stirring and dissolving completely for later use;
and a third step of: pumping the mixed phase B into a preheated emulsifying pot, slowly pumping the mixed phase A into the emulsifying pot, pre-emulsifying for 10 minutes, homogenizing for 5-10 minutes, uniformly stirring, vacuumizing, defoaming and cooling;
adding the phase C at 65 ℃ and uniformly stirring; adding phase D at 40 ℃, stirring uniformly, and discharging after physical and chemical indexes are checked to be qualified;
fifth step: after the semi-finished product is inspected to be qualified, filling, packaging, code spraying, and warehousing after the finished product is inspected to be qualified;
wherein, the A phase raw materials comprise mineral oil, caprylic/capric triglyceride, cyclomethicone, pyritan stearate, shea butter, tocopheryl acetate, polysorbate-60 and cetostearyl alcohol; phase B raw materials: water, nicotinamide, allantoin, disodium EDTA, and titanium dioxide; b1 phase raw materials: glycerol, xanthan gum; c phase raw materials: arbutin; d phase raw materials:
essence, phenoxyethanol and ethylhexyl glycerol.
CN202310445768.9A 2023-04-24 2023-04-24 Formula and preparation process of whitening and skin-tendering body milk Withdrawn CN116327616A (en)

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